CN103830685B - A kind of medicine for the treatment of facial neuritis - Google Patents
A kind of medicine for the treatment of facial neuritis Download PDFInfo
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- CN103830685B CN103830685B CN201410111290.7A CN201410111290A CN103830685B CN 103830685 B CN103830685 B CN 103830685B CN 201410111290 A CN201410111290 A CN 201410111290A CN 103830685 B CN103830685 B CN 103830685B
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Abstract
The present invention relates to a kind of medicine for the treatment of facial neuritis, it is made up by weight of following bulk drugs: Radix Habenariae Dentatae 8 parts, purslane speedwell Herba 6 parts, Herba Sedi tetractini 9 parts, Flos Chrysanthemi 7 parts, 5 parts, Semen Armeniacae Amarum, Herba Saussureae gramineae 6 parts, 9 parts, Herba Coriandri, Radix Loxostigmatis griffithii 5 parts, Radix Platycodonis 7 parts, Gaultheria 3 parts, 8 parts, Radix Glycyrrhizae, Fructus Perillae 6 parts, 3 parts, cliff lotus, Endothelium Corneum Gigeriae Galli 5 parts, 6 parts, Poria, Rhizoma Curcumae 3 parts, Radix Loti Corniculati 2 parts, Semen Canavaliae 3 parts, Herba Oenanthes Javanicae 2 parts and Rhizoma Polygoni Cuspidati 3 parts.The medicament composing prescription for the treatment of facial neuritis of the present invention is reasonable, has determined curative effect, safe ready, has no side effect, cheap feature.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicine for the treatment of facial neuritis.
Background technology
Facial neuritis, also known as Bell's palsy, refers to peripheral facial paralysis caused by nervus facialis nonspecific inflammation in stylomastoid foramen, paralyses suddenly for feature mainly with one-sided facial expression muscle.
Temple are important acupuncture points of head part, will rub this cave and be classified as " return of spring method " in " Bodhidharma secret recipe ", think that this method conventional can keep the youth of brain to be everlasting, and recover one's youthful vigour.Modern study shows, often produces unexpected excellent effect in temple dispenser, is even more important for head disease.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of facial neuritis.
In order to realize object of the present invention, the invention provides a kind of medicine for the treatment of facial neuritis, it is made up by weight of following bulk drugs: Radix Habenariae Dentatae 8 parts, purslane speedwell Herba 6 parts, Herba Sedi tetractini 9 parts, Flos Chrysanthemi 7 parts, 5 parts, Semen Armeniacae Amarum, Herba Saussureae gramineae 6 parts, 9 parts, Herba Coriandri, Radix Loxostigmatis griffithii 5 parts, Radix Platycodonis 7 parts, Gaultheria 3 parts, 8 parts, Radix Glycyrrhizae, Fructus Perillae 6 parts, 3 parts, cliff lotus, Endothelium Corneum Gigeriae Galli 5 parts, 6 parts, Poria, Rhizoma Curcumae 3 parts, Radix Loti Corniculati 2 parts, Semen Canavaliae 3 parts, Herba Oenanthes Javanicae 2 parts and Rhizoma Polygoni Cuspidati 3 parts.
Preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or decoction.
More preferably, described medicine is prepared by following method: get Radix Habenariae Dentatae 800 grams, purslane speedwell Herba 600 grams, Herba Sedi tetractini 900 grams, Flos Chrysanthemi 700 grams, 500 grams, Semen Armeniacae Amarum, Herba Saussureae gramineae 600 grams, 900 grams, Herba Coriandri, Radix Loxostigmatis griffithii 500 grams, Radix Platycodonis 700 grams, Gaultheria 300 grams, 800 grams, Radix Glycyrrhizae, Fructus Perillae 600 grams, 300 grams, cliff lotus, Endothelium Corneum Gigeriae Galli 500 grams, 600 grams, Poria, Rhizoma Curcumae 300 grams, Radix Loti Corniculati 200 grams, Semen Canavaliae 300 grams, Herba Oenanthes Javanicae 200 grams and Rhizoma Polygoni Cuspidati 300 grams, add 50 liters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue and filtrate 1; In filtering residue, add 30 liters, water, under the condition of backflow, heating 3 hours, filters, obtains filtering residue and filtrate 2; Merging filtrate 1 and filtrate 2, relative density 1.20 at being concentrated into 50 DEG C, inlet temperature be 110 DEG C, infusion pump rotating speed carries out spraying dry under being the condition of 30r/min, thus obtain dried powder, lanoline 600 grams is added in above-mentioned powder, be stirred into paste, be coated on breathability sticker, evenly cut into 1000 patches.
The present invention also provides the application of medicament in the medicine of preparation treatment facial neuritis, and described medicament is made up by weight of following bulk drugs: Radix Habenariae Dentatae 8 parts, purslane speedwell Herba 6 parts, Herba Sedi tetractini 9 parts, Flos Chrysanthemi 7 parts, 5 parts, Semen Armeniacae Amarum, Herba Saussureae gramineae 6 parts, 9 parts, Herba Coriandri, Radix Loxostigmatis griffithii 5 parts, Radix Platycodonis 7 parts, Gaultheria 3 parts, 8 parts, Radix Glycyrrhizae, Fructus Perillae 6 parts, 3 parts, cliff lotus, Endothelium Corneum Gigeriae Galli 5 parts, 6 parts, Poria, Rhizoma Curcumae 3 parts, Radix Loti Corniculati 2 parts, Semen Canavaliae 3 parts, Herba Oenanthes Javanicae 2 parts and Rhizoma Polygoni Cuspidati 3 parts.
In order to understand the present invention better, with reference to " Chinese medicine voluminous dictionary " second edition (Shanghai science tech publishing house, 2005), the explanation of some crude drug used in the present invention sees the following form:
Generally acknowledged that " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the traditional Chinese medical science the most effective most scientific several large advantages at present, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.The tight compatibility that in traditional Chinese medical science prescription, each medicine is all linked with one another as arrayed troops for battle is that it is better than the effective means of Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical side by too many levels, Mutiple Targets Integrate adjustment biological mechanism, can to obtain than Western medicine more lastingly, the more therapeutic effect that has no side effect of green natural, and this curative effect be based upon the above-mentioned traditional Chinese medical science tradition original theory accurate instruction on, the present invention just have followed this principle.In the present invention, Radix Habenariae Dentatae, purslane speedwell Herba, Herba Sedi tetractini are monarch drug; Flos Chrysanthemi, Semen Armeniacae Amarum, Herba Saussureae gramineae, Herba Coriandri, Radix Loxostigmatis griffithii, Radix Platycodonis, Gaultheria are ministerial drug; Radix Glycyrrhizae, Fructus Perillae, cliff lotus, Endothelium Corneum Gigeriae Galli, Poria, Rhizoma Curcumae are adjuvant drug; Radix Loti Corniculati, Semen Canavaliae, Herba Oenanthes Javanicae and Rhizoma Polygoni Cuspidati coordinating the actions of various ingredients in a prescription, play the effect making medicine in the compositions of the present invention.All medicines are harmonious in the present invention, reasonable recipe, have determined curative effect, safe ready, have no side effect, cheap feature.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment patch of the present invention
Get Radix Habenariae Dentatae 800 grams, purslane speedwell Herba 600 grams, Herba Sedi tetractini 900 grams, Flos Chrysanthemi 700 grams, 500 grams, Semen Armeniacae Amarum, Herba Saussureae gramineae 600 grams, 900 grams, Herba Coriandri, Radix Loxostigmatis griffithii 500 grams, Radix Platycodonis 700 grams, Gaultheria 300 grams, 800 grams, Radix Glycyrrhizae, Fructus Perillae 600 grams, 300 grams, cliff lotus, Endothelium Corneum Gigeriae Galli 500 grams, 600 grams, Poria, Rhizoma Curcumae 300 grams, Radix Loti Corniculati 200 grams, Semen Canavaliae 300 grams, Herba Oenanthes Javanicae 200 grams and Rhizoma Polygoni Cuspidati 300 grams, add 50 liters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue and filtrate 1; In filtering residue, add 30 liters, water, under the condition of backflow, heating 3 hours, filters, obtains filtering residue and filtrate 2; Merging filtrate 1 and filtrate 2, relative density 1.20 at being concentrated into 50 DEG C, use ZLPG6-10 spray dryer (Jiangsu Fan Qun drying equipment factory) inlet temperature be 110 DEG C, infusion pump rotating speed carries out spraying dry under being the condition of 30r/min, thus obtain dried powder, lanoline 600 grams is added in above-mentioned powder, be stirred into paste, be coated on breathability sticker, evenly cut into 1000 patches.
Experimental example
Case selection patient
96 examples, man 49 example, female 47 example, 31 years old mean age (25-45 year), the course of disease 1 week interior 31 example, 43 examples within 2 weeks more than January are 22 examples, be divided into treatment group and matched group, two groups of state of an illness, sex, age, course of disease no significant difference after statistical procedures, have comparability.
Diagnostic criteria
All meet the diagnostic criteria of " practical combination of Chinese and Western medicine internal medicine " facial neuritis of CHEN Ke ji chief editor.All patients all has single side face neural paralysis, Ipsilateral eyelid can not close or dysraphism, and Bell levies the positive, and tear is excessive, Ipsilateral volume stricture of vagina disappears, can not frown, nasolabial fold shoals or disappears, and bicker is askew to strong side, food remains between Ipsilateral tooth cheek, the bulging cheek or action of whistling can not be done, without Hunt syndrome, have 2/3 lingual surface hypogeusia before 39 routine patient's Ipsilateral tongues.The peripheral facial paralysis caused by Guillain Barre syndrome, brain stem lesions, Skull base lesion gill source property disease is got rid of by clinical manifestation and neurologic check.
Treatment group 57 example, man 35 example, female 22 example, 30.6 years old mean age.Use the patch prepared in embodiment to treat, once a day, respectively attach subsides in the temple, left and right of patient at every turn, treat 20 days.
Matched group 39 example, man 29 example, female 10 example, 31 years old mean age.Use vitamin B
12500 and V vitamin B
1100mg intramuscular injection, qd, oral prednisone 30mg, morning every day takes.Treat 20 days.
Criterion of therapeutical effect
Criterion of therapeutical effect reference " common clinical diagnostic criteria " (Tao Tianzun. clinical common disease diagnostic criteria [M]. Beijing: Beijing Medical people learns, conjunction publishing house of consonance medical courses in general people student's federation of China, 1999.) formulation.Recovery from illness: patient's catacleisis is normal, and Bell levies feminine gender, without the excessive symptom of tear, patient's volume stricture of vagina recovers, and can frown, and nasolabial fold bilateral is consistent, and bicker is not askew, can do the bulging cheek and action of whistling, and before patient's tongue, 1/3 sense of taste is recovered.Effective: catacleisis is normal, and excessive without tear, patient's volume stricture of vagina is slightly shallow, can frown, and patient's nasolabial fold is slightly shallow, bicker is closed not askew, but slightly crooked when Lu Ya or laugh, and the lingual surface sense of taste is recovered.Invalid: to leave over permanent facial paralysis, mouth eye snail is oblique, facial spasm or shed tears.
Result
Treatment group recovery from illness 38 example, effective 18 examples, invalid 1 example, total effective rate 98.3%.Matched group recovery from illness 20 example, effective 14 examples, invalid 5 examples, total effective rate 86.8%.Treatment group is evident in efficacy higher than matched group, and P<0.05 the results are shown in Table.
Table 1 clinical efficacy (n, %)
Claims (1)
1. treat the medicine of facial neuritis for one kind, it is characterized in that, it is made up by weight of following bulk drugs: Radix Habenariae Dentatae 8 parts, purslane speedwell Herba 6 parts, Herba Sedi tetractini 9 parts, Flos Chrysanthemi 7 parts, 5 parts, Semen Armeniacae Amarum, Herba Saussureae gramineae 6 parts, 9 parts, Herba Coriandri, Radix Loxostigmatis griffithii 5 parts, Radix Platycodonis 7 parts, Gaultheria 3 parts, 8 parts, Radix Glycyrrhizae, Fructus Perillae 6 parts, 3 parts, cliff lotus, Endothelium Corneum Gigeriae Galli 5 parts, 6 parts, Poria, Rhizoma Curcumae 3 parts, Radix Loti Corniculati 2 parts, Semen Canavaliae 3 parts, Herba Oenanthes Javanicae 2 parts and Rhizoma Polygoni Cuspidati 3 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410111290.7A CN103830685B (en) | 2014-03-24 | 2014-03-24 | A kind of medicine for the treatment of facial neuritis |
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| CN201410111290.7A CN103830685B (en) | 2014-03-24 | 2014-03-24 | A kind of medicine for the treatment of facial neuritis |
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| CN103830685A CN103830685A (en) | 2014-06-04 |
| CN103830685B true CN103830685B (en) | 2015-11-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884715A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating optic neuritis and preparation method thereof |
| CN102935162A (en) * | 2012-11-25 | 2013-02-20 | 郎艳萍 | Pills for retrobulbar neuritis and preparation method |
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2014
- 2014-03-24 CN CN201410111290.7A patent/CN103830685B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884715A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating optic neuritis and preparation method thereof |
| CN102935162A (en) * | 2012-11-25 | 2013-02-20 | 郎艳萍 | Pills for retrobulbar neuritis and preparation method |
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