CN103830685A - Medicament for treating facial neuritis - Google Patents
Medicament for treating facial neuritis Download PDFInfo
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- CN103830685A CN103830685A CN201410111290.7A CN201410111290A CN103830685A CN 103830685 A CN103830685 A CN 103830685A CN 201410111290 A CN201410111290 A CN 201410111290A CN 103830685 A CN103830685 A CN 103830685A
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Abstract
The invention relates to a medicament for treating facial neuritis. The medicament is prepared from the following raw medicinal materials in parts by weight: 8 parts of toothed habenaria root, 6 parts of purslane speedwell herb, 9 parts of fourarista stonecrop herb, 7 parts of flos chrysanthemi, 5 parts of apricot kernels, 6 parts of saussurea graminea, 9 parts of coriander, 5 parts of Lepisorus eilophyllus, 7 parts of platycodon grandiflorum, 3 parts of Gaultheria leucocarpa, 8 parts of liquorice, 6 parts of fructus perillae, 3 parts of Colysis digitata, 5 parts of endothelium corneum gigeriae galli, 6 parts of poria cocos, 3 parts of rhizoma zedoariae, 2 parts of lotus corniculatus, 3 parts of sword beans, 2 parts of water fennels and 3 parts of giant knotweed rhizome. The medicament for treating the facial neuritis, which is disclosed by the invention, is reasonable in formula and has the characteristics of definiteness in treatment effect, safety, convenience, no toxic and side effect and low price.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicine for the treatment of facial neuritis.
Background technology
Facial neuritis, claims again Bell's palsy, refers in stylomastoid foramen peripheral facial paralysis due to nervus facialis nonspecific inflammation, is feature mainly with the paralysis suddenly of one-sided facial expression muscle.
Temple are important acupuncture points of head part, will rub this cave and classify " return of spring method " as in " Bodhidharma secret recipe ", think that conventional this method can keep the youth of brain to be everlasting, and recovers one's youthful vigour.Modern study shows, tends to produce unexpected excellent effect in temple dispenser, for head disease, is even more important.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of facial neuritis.
In order to realize object of the present invention, the invention provides a kind of medicine for the treatment of facial neuritis, it is to be made up by weight of following bulk drugs: 3 parts of 8 parts of Radix Habenariae Dentataes, 6 parts of purslane speedwell Herbas, 9 parts of Herba Sedi tetractinis, 7 parts of Flos Chrysanthemis, 5 parts, Semen Armeniacae Amarum, 6 parts of Herba Saussureae gramineaes, 9 parts, Herba Coriandri, 5 parts of Radix Loxostigmatis griffithii, 7 parts of Radix Platycodoniss, 3 parts of Gaultherias, 8 parts, Radix Glycyrrhizae, 6 parts of Fructus Perillaes, 3 parts, cliff lotus, 5 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Poria, 3 parts of Rhizoma Curcumae, 2 parts of Radix Loti Corniculatis, 3 parts of Semen Canavaliaes, 2 parts of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati.
Preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, patch or decoction.
More preferably, described medicine is prepared by following method: get 300 grams of 800 grams of Radix Habenariae Dentataes, 600 grams of purslane speedwell Herbas, 900 grams of Herba Sedi tetractinis, 700 grams of Flos Chrysanthemis, 500 grams, Semen Armeniacae Amarum, 600 grams of Herba Saussureae gramineaes, 900 grams, Herba Coriandri, 500 grams of Radix Loxostigmatis griffithii, 700 grams of Radix Platycodoniss, 300 grams of Gaultherias, 800 grams, Radix Glycyrrhizae, 600 grams of Fructus Perillaes, 300 grams, cliff lotus, 500 grams of Endothelium Corneum Gigeriae Galli, 600 grams, Poria, 300 grams of Rhizoma Curcumae, 200 grams of Radix Loti Corniculatis, 300 grams of Semen Canavaliaes, 200 grams of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati, add 50 liters, water, under the condition refluxing, heat 5 hours, filter, obtain filtering residue and filtrate 1; In filtering residue, add 30 liters, water, under the condition refluxing, heat 3 hours, filter, obtain filtering residue and filtrate 2; Merging filtrate 1 and filtrate 2, be concentrated into relative density 1.20 at 50 ℃, inlet temperature be under 110 ℃, the infusion pump rotating speed condition that is 30r/min, spray dry, thereby obtain dried powder, in above-mentioned powder, add 600 grams of lanolines, be stirred into paste, be coated on breathability sticker, evenly cut into 1000 patches.
The present invention also provides the application of medicament in the medicine of preparation treatment facial neuritis, and described medicament is to be made up by weight of following bulk drugs: 3 parts of 8 parts of Radix Habenariae Dentataes, 6 parts of purslane speedwell Herbas, 9 parts of Herba Sedi tetractinis, 7 parts of Flos Chrysanthemis, 5 parts, Semen Armeniacae Amarum, 6 parts of Herba Saussureae gramineaes, 9 parts, Herba Coriandri, 5 parts of Radix Loxostigmatis griffithii, 7 parts of Radix Platycodoniss, 3 parts of Gaultherias, 8 parts, Radix Glycyrrhizae, 6 parts of Fructus Perillaes, 3 parts, cliff lotus, 5 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Poria, 3 parts of Rhizoma Curcumae, 2 parts of Radix Loti Corniculatis, 3 parts of Semen Canavaliaes, 2 parts of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati.
In order to understand better the present invention, with reference to " Chinese medicine voluminous dictionary " second edition (Shanghai science tech publishing house, 2005), the explanation of some crude drug that use in the present invention sees the following form:
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, can obtain than Western medicine more lastingly, therapeutic effect that more green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, the present invention is just following this principle.In the present invention, Radix Habenariae Dentatae, purslane speedwell Herba, Herba Sedi tetractini are monarch drug; Flos Chrysanthemi, Semen Armeniacae Amarum, Herba Saussureae gramineae, Herba Coriandri, Radix Loxostigmatis griffithii, Radix Platycodonis, Gaultheria are ministerial drug; Radix Glycyrrhizae, Fructus Perillae, cliff lotus, Endothelium Corneum Gigeriae Galli, Poria, Rhizoma Curcumae are adjuvant drug; Radix Loti Corniculati, Semen Canavaliae, Herba Oenanthes Javanicae and Rhizoma Polygoni Cuspidati coordinating the actions of various ingredients in a prescription play the effect that makes medicine in the present composition.All medicines are harmonious in the present invention, and reasonable recipe has determined curative effect, safe ready, has no side effect, cheap feature.
The specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent otherwise in the present invention is percetage by weight.
Embodiment patch of the present invention
Get 300 grams of 800 grams of Radix Habenariae Dentataes, 600 grams of purslane speedwell Herbas, 900 grams of Herba Sedi tetractinis, 700 grams of Flos Chrysanthemis, 500 grams, Semen Armeniacae Amarum, 600 grams of Herba Saussureae gramineaes, 900 grams, Herba Coriandri, 500 grams of Radix Loxostigmatis griffithii, 700 grams of Radix Platycodoniss, 300 grams of Gaultherias, 800 grams, Radix Glycyrrhizae, 600 grams of Fructus Perillaes, 300 grams, cliff lotus, 500 grams of Endothelium Corneum Gigeriae Galli, 600 grams, Poria, 300 grams of Rhizoma Curcumae, 200 grams of Radix Loti Corniculatis, 300 grams of Semen Canavaliaes, 200 grams of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati, add 50 liters, water, under the condition refluxing, heat 5 hours, filter, obtain filtering residue and filtrate 1; In filtering residue, add 30 liters, water, under the condition refluxing, heat 3 hours, filter, obtain filtering residue and filtrate 2; Merging filtrate 1 and filtrate 2, be concentrated into relative density 1.20 at 50 ℃, using ZLPG6-10 spray dryer (Jiangsu Fan Qun drying equipment factory) is spray and be dried under 110 ℃, the infusion pump rotating speed condition that is 30r/min in inlet temperature, thereby obtain dried powder, in above-mentioned powder, add 600 grams of lanolines, be stirred into paste, be coated on breathability sticker, evenly cut into 1000 patches.
Experimental example
Case selection patient
96 examples, male 49 examples, female's 47 examples, 31 years old mean age (25-45 year), 1 week interior 31 example of the course of disease, within 2 weeks, with interior 43 examples, be 22 examples January above, be divided into treatment group and matched group, two groups of state of an illness, sex, age, courses of disease are learned by statistics and are processed rear no significant difference, have comparability.
Diagnostic criteria
All meet the diagnostic criteria of " practical combination of Chinese and Western medicine internal medicine " facial neuritis of Chen Keji chief editor.All patients all has single side face neural paralysis, Ipsilateral eyelid can not closure or dysraphism, and Bell levies the positive, and tear is excessive, Ipsilateral volume stricture of vagina disappears, can not frown, nasolabial fold shoals or disappears, and bicker is askew to strong side, between the residual Ipsilateral tooth of food cheek, can not do the bulging cheek or the action of whistling, without Hunt syndrome, have the front 2/3 lingual surface hypogeusia of 39 routine patient's Ipsilateral tongue.Get rid of the peripheral facial paralysis due to Guillain Barre syndrome, brain stem lesions, basis cranii pathological changes gill source property disease by clinical manifestation and neurologic check.
Treatment group 57 examples, male 35 examples, female's 22 examples, 30.6 years old mean age.Treat with the patch of preparing in embodiment, once a day, paste in the each attaching one in patient's temple, left and right at every turn, treat 20 days.
Matched group 39 examples, male 29 examples, female's 10 examples, 31 years old mean age.Use vitamin B
12500 and V vitamin B
1100mg intramuscular injection, qd, oral prednisone 30mg, take morning every day.Treat 20 days.
Criterion of therapeutical effect
Criterion of therapeutical effect reference " common clinical diagnostic criteria " (Tao Tianzun. clinical common disease diagnostic criteria [M]. Beijing: Beijing medical courses in general people learns, China coordinates, and publishing house is closed, 1999. by medical courses in general people student's federation) formulate.Recovery from illness: patient's catacleisis is normal, and Bell levies feminine gender, without the excessive symptom of tear, patient's volume stricture of vagina recovers, and can frown, and nasolabial fold bilateral is consistent, and bicker is not askew, can do the bulging cheek and the action of whistling, and front 1/3 sense of taste of patient's tongue is recovered.Effective: catacleisis is normal, excessive without tear, patient's volume stricture of vagina is slightly shallow, can frown, and patient's nasolabial fold is slightly shallow, and bicker closure is not askew, but slightly crooked in the time of Lu Ya or laugh, the lingual surface sense of taste is recovered.Invalid: leave over permanent facial paralysis, mouthful eye snail is oblique, facial spasm or shed tears.
Result
Treatment group 38 examples of fully recovering, effective 18 examples, invalid 1 example, total effective rate 98.3%.Matched group 20 examples of fully recovering, effective 14 examples, invalid 5 examples, total effective rate 86.8%.Treatment group is evident in efficacy higher than matched group, and P<0.05 the results are shown in Table.
Table 1 clinical efficacy (n, %)
Claims (4)
1. treat the medicine of facial neuritis for one kind, it is characterized in that, it is to be made up by weight of following bulk drugs: 3 parts of 8 parts of Radix Habenariae Dentataes, 6 parts of purslane speedwell Herbas, 9 parts of Herba Sedi tetractinis, 7 parts of Flos Chrysanthemis, 5 parts, Semen Armeniacae Amarum, 6 parts of Herba Saussureae gramineaes, 9 parts, Herba Coriandri, 5 parts of Radix Loxostigmatis griffithii, 7 parts of Radix Platycodoniss, 3 parts of Gaultherias, 8 parts, Radix Glycyrrhizae, 6 parts of Fructus Perillaes, 3 parts, cliff lotus, 5 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Poria, 3 parts of Rhizoma Curcumae, 2 parts of Radix Loti Corniculatis, 3 parts of Semen Canavaliaes, 2 parts of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati.
2. the medicine for the treatment of facial neuritis according to claim 1, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, patch or decoction.
3. the medicine for the treatment of facial neuritis according to claim 1, it is characterized in that, described medicine is prepared by following method: get 800 grams of Radix Habenariae Dentataes, 600 grams of purslane speedwell Herbas, 900 grams of Herba Sedi tetractinis, 700 grams of Flos Chrysanthemis, 500 grams, Semen Armeniacae Amarum, 600 grams of Herba Saussureae gramineaes, 900 grams, Herba Coriandri, 500 grams of Radix Loxostigmatis griffithii, 700 grams of Radix Platycodoniss, 300 grams of Gaultherias, 800 grams, Radix Glycyrrhizae, 600 grams of Fructus Perillaes, 300 grams, cliff lotus, 500 grams of Endothelium Corneum Gigeriae Galli, 600 grams, Poria, 300 grams of Rhizoma Curcumae, 200 grams of Radix Loti Corniculatis, 300 grams of Semen Canavaliaes, 300 grams of 200 grams of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati, add 50 liters, water, under the condition refluxing, heat 5 hours, filter, obtain filtering residue and filtrate 1, in filtering residue, add 30 liters, water, under the condition refluxing, heat 3 hours, filter, obtain filtering residue and filtrate 2, merging filtrate 1 and filtrate 2, be concentrated into relative density 1.20 at 50 ℃, inlet temperature be under 110 ℃, the infusion pump rotating speed condition that is 30r/min, spray dry, thereby obtain dried powder, in above-mentioned powder, add 600 grams of lanolines, be stirred into paste, be coated on breathability sticker, evenly cut into 1000 patches.
4. the application of medicament in the medicine of preparation treatment facial neuritis, it is characterized in that, described medicament is to be made up by weight of following bulk drugs: 3 parts of 8 parts of Radix Habenariae Dentataes, 6 parts of purslane speedwell Herbas, 9 parts of Herba Sedi tetractinis, 7 parts of Flos Chrysanthemis, 5 parts, Semen Armeniacae Amarum, 6 parts of Herba Saussureae gramineaes, 9 parts, Herba Coriandri, 5 parts of Radix Loxostigmatis griffithii, 7 parts of Radix Platycodoniss, 3 parts of Gaultherias, 8 parts, Radix Glycyrrhizae, 6 parts of Fructus Perillaes, 3 parts, cliff lotus, 5 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Poria, 3 parts of Rhizoma Curcumae, 2 parts of Radix Loti Corniculatis, 3 parts of Semen Canavaliaes, 2 parts of Herba Oenanthes Javanicaes and Rhizoma Polygoni Cuspidati.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410111290.7A CN103830685B (en) | 2014-03-24 | 2014-03-24 | A kind of medicine for the treatment of facial neuritis |
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|---|---|---|---|
| CN201410111290.7A CN103830685B (en) | 2014-03-24 | 2014-03-24 | A kind of medicine for the treatment of facial neuritis |
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| CN103830685A true CN103830685A (en) | 2014-06-04 |
| CN103830685B CN103830685B (en) | 2015-11-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884715A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating optic neuritis and preparation method thereof |
| CN102935162A (en) * | 2012-11-25 | 2013-02-20 | 郎艳萍 | Pills for retrobulbar neuritis and preparation method |
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2014
- 2014-03-24 CN CN201410111290.7A patent/CN103830685B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884715A (en) * | 2010-07-08 | 2010-11-17 | 张秀兰 | Medicament for treating optic neuritis and preparation method thereof |
| CN102935162A (en) * | 2012-11-25 | 2013-02-20 | 郎艳萍 | Pills for retrobulbar neuritis and preparation method |
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| CN103830685B (en) | 2015-11-18 |
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