CN101884715A - Medicament for treating optic neuritis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating optic neuritis, which is prepared from the following raw materials in a certain ratio: cinnamomvine, mandarin peel, Indian buead, common macrocarpium fruit, bat dung, Chinese atractylodes rhizome and the like. The medicament for treating the optic neuritis has the advantages of quick response and high cure rate.

Description

A kind of medicine for the treatment of optic neuritis and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of optic neuritis and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Optic neuritis is meant the general name of optic nerve any position inflammation, diseases such as the inflammatory demyelination of general reference optic nerve, infection, nonspecific inflammation.Due to illness the position of loss on transmission evil is different and be divided into the retrobulbar neuritis of the papillitis optica and the ball back segment of ball inner segment.During sick sending out, symptom is mainly visual deterioration, in addition the morbidity a few days can reduce to light sensation or not have light sensation, eyeball rear portion traction sample pain when eyeball rotates, socket of the eye deep tenderness, pupillary light reflex is blunt or disappear, or light reflex is not lasting.Clinical treatment is many based on doctor trained in Western medicine now, for acute patient, uses the 17-hydroxy-11-dehydrocorticosterone therapy more, or utilizes vasodilation: retrobulbar injection benzazoline or oral benzazoline, nicotinic acid etc.Daily diagnosis and treatment are many, and once a day, also available adenosine triphosphate 20mg intramuscular injection meets infection conditions once a day with vitamin B1 and vitamin B12 intramuscular injection, uses antibiotic to carry out anti-infective therapy.These medicines just carry out part alleviation or treatment to optic neuritis, and the hormone medicine side effect is big, weak effect, the recurrence and the radical cure that can't solve optic neuritis.

Summary of the invention:

Therefore people to curative effect preferably the Chinese medicine medicine have great demand, up to now, also do not find relevant report about medicine of the present invention, the inventor on the basis of secret prescription handed down in the family from generation to generation again through repeatedly research, and test opinion repeatedly by clinical trial, finally worked out the Chinese medicine medicine of treatment optic neuritis, thereby finished the present invention with better curative effect.

Purpose of the present invention just provides a kind of Chinese medicine medicine of more effectively treating optic neuritis.

Another object of the present invention has just provided the preparation method of this Chinese medicine medicine.

Medicine of the present invention selects Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Citrus chachiensis Hort. C. Suavissima Tanaka, Poria, Rhizoma Alismatis, Fructus Corni, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Faeces Vespertilionis, Rhizoma Atractylodis, Semen Ziziphi Spinosae, Radix Glycyrrhizae to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of optic neuritis.It is sweet owing to its nature and flavor, flat wherein selecting Rhizoma Dioscoreae for use.Go into lung, spleen, kidney channel.Strengthening the spleen and tonifying the lung reinforces the kidney, and benefit is smart.Control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, leukorrhagia, frequent micturition.Select for use Radix Rehmanniae Preparata be because the Radix Rehmanniae Preparata nature and flavor sweet, tepor, return through, return liver, kidney channel, cure mainly nourishing YIN and supplementing blood, beneficial essence is filled out marrow, is used for the hepatic and renal YIN deficiency, soreness of the waist and knees, hectic fever due to YIN-deficiency, hectic fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Select for use Citrus chachiensis Hort. C. Suavissima Tanaka to be because its property acrid-sweet flavor is cold, nontoxic.Drinking and eating irregularly after curing the disease, last gas stuffy sensation with restlessness, it is thirsty to get sick from drinking too much wine.Selecting Poria for use is because the Poria slightly sweet flavor, flat, return through, go into the heart, spleen, lung meridian, eliminating dampness and diuresis, the strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming is controlled dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge is palpitated with fear, and is forgetful.It is sweet owing to its nature and flavor, cold selecting Rhizoma Alismatis for use.Go into kidney, urinary bladder channel.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Selecting Fructus Corni for use is owing to its nature and flavor acid, tepor.Go into liver, nontoxic.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, the deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Select for use Radix Aconiti Lateralis Preparata to be because its suffering is sweet, hot, poisonous.Go into the heart, spleen, kidney channel.Control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, anemofrigid-damp arthralgia, contracture, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Selecting Cortex Cinnamomi for use is owing to its property acrid-sweet flavor, heat.Go into kidney, spleen, urinary bladder channel.Complement the moon, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, the amenorrhea lump in the abdomen, carbuncle of yin nature, stream is controlled, and empty sun is more floating, heat in the upper and cold in the lower.Select for use Faeces Vespertilionis to be because its nature and flavor suffering, cold.Go into Liver Channel.Clearing away heat to improve acuity of vision, the heat radiation removing food stagnancy.Control the optic atrohic blindness nyctalopia, inside and outside hide from view scrofula, infantile malnutrition, malaria.Select for use Rhizoma Atractylodis to be because its nature and flavor are arduous, warm.Go into spleen, stomach warp.Spleen invigorating, dampness, resolving depression is warded off dirty.Administer to contain and be stranded spleen, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting is had loose bowels, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select for use Semen Ziziphi Spinosae to be because its nature and flavor hardship, flat, nontoxic.Control the shin skin ulcer, acute gangrenous stomatitis.It is sweet owing to its nature and flavor, flat selecting Radix Glycyrrhizae for use.Go into spleen, stomach, lung meridian.Control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following weight range:

Rhizoma Dioscoreae 6-12 gram Radix Rehmanniae Preparata 10-20 gram Citrus chachiensis Hort. C. Suavissima Tanaka 8-12 gram

Poria 10-15 gram Rhizoma Alismatis 4-10 Keshan Fructus Evodiae 5-10 gram

Radix Aconiti Lateralis Preparata 3-8 gram Cortex Cinnamomi 4-10 gram Faeces Vespertilionis 10-20 gram

Rhizoma Atractylodis 10-15 gram Semen Ziziphi Spinosae 10-18 gram Radix Glycyrrhizae 5-8 gram

Be preferably: Rhizoma Dioscoreae 9 grams, Radix Rehmanniae Preparata 12 grams, Citrus chachiensis Hort. C. Suavissima Tanaka 9 grams, Poria 12 grams, Rhizoma Alismatis 6 grams, Fructus Corni 9 grams, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 6 grams, Faeces Vespertilionis 15 grams, Rhizoma Atractylodis 12 grams, Semen Ziziphi Spinosae 15 grams, Radix Glycyrrhizae 6 grams.

Medicine of the present invention is to get above-mentioned dosage medical material, and water decocts, and filters out impurities, oral getting final product.

The preparation method of medicine of the present invention is as follows:

One, gets the raw materials ready

1, Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

2, Radix Rehmanniae Preparata: get crude drug, steam, take out, when solarization is done to about eighty per cant, cut sheet or piece, drying to surperficial corvinus;

3, Citrus chachiensis Hort. C. Suavissima Tanaka: brush away earth, choose clean impurity, the spray clear water, shredding or section are dried behind the moistening;

4, Poria: be soaked in water, clean, pull out vexed after, section is dried;

5, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water, and pulls out thoroughly to eighty per cant, and solarization is dried in the air, and moistening is even to inside and outside humidity, and section is dried;

6, Fructus Corni: clean, remove removal core and impurity, dry;

7, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, removes the peeling umbilicus, section, add blister to mouth again and taste and spicy sense is arranged slightly, take out, soaked 1-3 days, cook then with ginger decoction for degree, bake to seventy percent again and do, pour urgent the stir-fry to cigarette of useing force in the pot into and rise, it is degree that little drum splits, and taking-up cools;

8, Cortex Cinnamomi: choose clean impurity, peel off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

9, Faeces Vespertilionis: choose clean impurity, the silt particle of winnowing with a dustpan, or dry after the rinsing;

10, Rhizoma Atractylodis: choose decontamination,, pull out, run through the back section, dry with blister to seven, most probably saturating;

11, Semen Ziziphi Spinosae: choose clean impurity, the silt particle of winnowing with a dustpan, or dry after the rinsing;

12, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through, section is dried.

Two, preparation method:

By measuring sufficient Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Citrus chachiensis Hort. C. Suavissima Tanaka, Poria, Rhizoma Alismatis, Fructus Corni, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Faeces Vespertilionis, Rhizoma Atractylodis, Semen Ziziphi Spinosae, Radix Glycyrrhizae medicine, adding water 600 grams-700 grams soaked after 20 minutes, decoct with high heat, after the medicinal liquid boiling, change by slow fire boiling 15-20 minute, decoct after-filtration, get its medicinal liquid.

Secondary adds water 500 grams when decocting, wait the medicinal liquid boiling after, its medicinal liquid of leaching is crossed in slow fire boiling 15 minutes.

Medicine of the present invention is a secret prescription handed down in the family from generation to generation, and it is fast to be used for the treatment of the optic neuritis curative effect, the cure rate height.

The specific embodiment:

Below further set forth the beneficial effect of medicine of the present invention by testing example.

[test example 1] animal experiment report:

Get New Zealand man and exempt from 20, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and 10 every group, wherein one group is the normal amount toxicity test, and another group is the excess toxicity test.

The normal amount toxicity test: get the said medicine oral liquid, administering mode is a gastric infusion, and every day twice, each consumption 15ml continuous 18 days, observes 10 all no abnormal reactions of rabbit every day.

The excess toxicity test: get the above-mentioned medicine oral liquid for preparing, 10 rabbit of gastric infusion, every day three times, each consumption is 30ml, logotype 18 days there is no abnormal response.

Evidence, medicine of the present invention has no side effect.

The clinical observation of [test example 2] Drug therapy optic neuritis of the present invention

1, physical data

Accept out-patient's totally 300 examples for medical treatment, wherein male 180 examples, women 120 examples, age 28-35 year 25 examples wherein, 36-40 year 98 examples, 41-50 year 126 examples, 51 examples more than 50 years old.

2, diagnostic criteria

Optic neuritis shows as visual deterioration, even morbidity can reduce to light sensation or not have light sensation a few days, eyeball rear portion traction sample pain when eyeball rotates, and socket of the eye deep tenderness, pupillary light reflex is blunt or disappear, or feature such as light reflex is not lasting.

3, Therapeutic Method

The oral medicine oral liquid of the present invention of secondary every day, each 200ml, 6 days is a course of treatment, cure three courses of treatment.

4, efficacy assessment standard

Produce effects: optic neuritis is after treatment, and vision restoration is normal, and eyeball does not have the tenderness sense when rotating, and observes 1 year no recidivist.

Take a turn for the better: optic neuritis is after treatment, and vision gets better every day, and recovers light sensation, and eyeball rotates idol the tenderness sense.In 1 year rebound phenomenon is arranged, add a course of treatment after, can cure.

Invalid: as not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy optic neuritis patient 300 examples of the present invention, produce effects 252 examples as a result, obvious effective rate is 84%, 42 examples that take a turn for the better, improvement rate is 14%, invalid 6 examples, total effective rate is 98%.

Claims (3)

1. medicine for the treatment of optic neuritis, it is characterized in that: it is to be made by the crude drug in the following weight range:

Rhizoma Dioscoreae 6-12 gram Radix Rehmanniae Preparata 10-20 gram Citrus chachiensis Hort. C. Suavissima Tanaka 8-12 gram

Poria 10-15 gram Rhizoma Alismatis 4-10 Keshan Fructus Evodiae 5-10 gram

Radix Aconiti Lateralis Preparata 3-8 gram Cortex Cinnamomi 4-10 gram Faeces Vespertilionis 10-20 gram

Rhizoma Atractylodis 10-15 gram Semen Ziziphi Spinosae 10-18 gram Radix Glycyrrhizae 58 grams.

2. medicine according to claim 1, wherein the consumption of each raw material is: Rhizoma Dioscoreae 9 grams, Radix Rehmanniae Preparata 12 grams, Citrus chachiensis Hort. C. Suavissima Tanaka 9 grams, Poria 12 grams, Rhizoma Alismatis 6 grams, Fructus Corni 9 grams, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 6 grams, Faeces Vespertilionis 15 grams, Rhizoma Atractylodis 12 grams, Semen Ziziphi Spinosae 15 grams, Radix Glycyrrhizae 6 grams.

3. according to the preparation method of claim 1 or 2 described medicines, comprise the following steps:

(1) gets the raw materials ready

(1) Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

(2) Radix Rehmanniae Preparata: get crude drug, steam, take out, when solarization is done to about eighty per cant, cut sheet or piece, drying to surperficial corvinus;

(3) Citrus chachiensis Hort. C. Suavissima Tanaka: brush away earth, choose clean impurity, the spray clear water, shredding or section are dried behind the moistening;

(4) Poria: be soaked in water, clean, pull out vexed after, section is dried;

(5) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water, and pulls out thoroughly to eighty per cant, and solarization is dried in the air, and moistening is even to inside and outside humidity, and section is dried;

(6) Fructus Corni: clean, remove removal core and impurity, dry;

(7) Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, removes the peeling umbilicus, section, add blister to mouth again and taste and spicy sense is arranged slightly, take out, soaked 1-3 days, cook then with ginger decoction for degree, bake to seventy percent again and do, pour urgent the stir-fry to cigarette of useing force in the pot into and rise, it is degree that little drum splits, and taking-up cools;

(8) Cortex Cinnamomi: choose clean impurity, peel off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

(9) Faeces Vespertilionis: choose clean impurity, the silt particle of winnowing with a dustpan, or dry after the rinsing;

(10) Rhizoma Atractylodis: choose decontamination,, pull out, run through the back section, dry with blister to seven, most probably saturating;

(11) Semen Ziziphi Spinosae: choose clean impurity, the silt particle of winnowing with a dustpan, or dry after the rinsing;

(12) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through, section is dried;

(2) preparation method:

By measuring sufficient Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Citrus chachiensis Hort. C. Suavissima Tanaka, Poria, Rhizoma Alismatis, Fructus Corni, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Faeces Vespertilionis, Rhizoma Atractylodis, Semen Ziziphi Spinosae, Radix Glycyrrhizae medicine, adding water 600 grams-700 grams soaked after 20 minutes, decoct with high heat, after the medicinal liquid boiling, change by slow fire boiling 15-20 minute, decoct after-filtration, get its medicinal liquid.