CN104721624A - Internal medicament for treating adenovirus pneumonia and preparation method of internal medicament - Google Patents
Internal medicament for treating adenovirus pneumonia and preparation method of internal medicament Download PDFInfo
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Abstract
The invention relates to an internal medicament for treating adenovirus pneumonia and a preparation method of the internal medicament. The medicament comprises the following components in parts by mass: 1-3 parts of mulberry leaves, 1-3 parts of chrysanthemum, 1-3 parts of stiff silkworms, 1-3 parts of apricot kernels, 1-3 parts of peppermint, 1-3 parts of platycodon root, 1-3 parts of reed rhizome, 1-3 parts of liquorice root, 1-3 parts of fructus forsythiae, 1-3 parts of cicada slough, 1-3 parts of kudzuvine root, 1-3 parts of baical skullcap root and 1-3 parts of fistular onion stalk. The preparation method of the medicament comprises the following steps: selecting high-quality first-class mulberry leaves, chrysanthemum, stiff silkworms, apricot kernels, peppermint, platycodon root, reed rhizome, liquorice root, fructus forsythiae, cicada slough, kudzuvine root, baical skullcap root and fistular onion stalk according to parts by mass, and in addition to peppermint and fistular onion stalk which are additionally packed and added later, putting the various medicines into a cloth bag and tying the cloth bag for later use; soaking the tied cloth bag in cold boiled water for about half an hour, continuously putting the soaked medicines into a casserole, injecting the cold boiled water till the cold boiled water is 35mm higher than the medicines, performing first decoction for 30min, filtering to obtain medicine liquid, re-injecting slightly warm boiled water into residues, performing second decoction for 25min, and merging and concentrating into 150ml of traditional Chinese medicine liquid with concentration of 50%.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of adenovirus pneumonia, particularly for the field of the endo-medicine and preparation method thereof of adenovirus pneumonia patient.
Background technology
The multiple colony of adenovirus pneumonia, adenovirus generally passes through respiratory tract infection.Often there is adenovirus upper respiratory tract infection and pneumonia in collective children mechanism simultaneously.Crowd's serological research illustrates, after raw, the initial several months often retains the adenovirus specific antibody transmitted from parent, ever since to 2 years old antibody deficiency, within 2 years old, just increases gradually later.The clinical observation that this and adenovirus pneumonia 80% occur in 7 ~ 24 months infant meets completely.It should be noted that local each age group Susceptible population quantity is more, the number that adenovirus respiratory tract infection occurs is just many, and the chance of infant generation adenovirus pneumonia is also larger.Adenovirus pneumonia is more common in winter and spring in northern China, and summer, autumn are only accidental, is then more common in autumn in the height in Guangzhou popular year.This parapneumonia accounts for 20% ~ 30% of viral pneumonia in Beijing.
So, just how finding a kind of endo-medicine effectively can treating adenovirus pneumonia, is our current problem in urgent need to solve.
Summary of the invention
The object of this invention is to provide a kind of endo-medicine for the treatment of adenovirus pneumonia and preparation method thereof, to solve the problem that adenovirus pneumonia patient fully recovers early.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, and hit pathogenesis, has fully demonstrated lung qi dispersing and has dispeled the wind and the pungent Therapeutic Principle shown that cools completely.
For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of adenovirus pneumonia and preparation method thereof, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Folium Mori 1-3 part;
Flos Chrysanthemi 1-3 part;
Bombyx Batryticatus 1-3 part;
Semen Armeniacae Amarum 1-3 part;
Herba Menthae 1-3 part;
Radix Platycodonis 1-3 part;
Rhizoma Phragmitis 1-3 part;
Radix Glycyrrhizae 1-3 part;
Fructus Forsythiae 1-3 part;
Periostracum Cicadae 1-3 part;
Radix Puerariae 1-3 part;
Radix Scutellariae 1-3 part;
Bulbus Allii Fistulosi 1-3 part.
According to the endo-medicine for the treatment of adenovirus pneumonia provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
1 part, Folium Mori;
Flos Chrysanthemi 1 part;
Bombyx Batryticatus 1 part;
1 part, Semen Armeniacae Amarum;
Herba Menthae 1 part;
Radix Platycodonis 1 part;
Rhizoma Phragmitis 1 part;
1 part, Radix Glycyrrhizae;
Fructus Forsythiae 1 part;
Periostracum Cicadae 1 part;
Radix Puerariae 1 part;
Radix Scutellariae 1 part;
Bulbus Allii Fistulosi 1 part.
A kind of endo-medicine for the treatment of adenovirus pneumonia and preparation method thereof, is characterized in that, described method comprises the steps:
A, 1 part, the one-level Folium Mori selecting high-quality clean, Flos Chrysanthemi 1 part, Bombyx Batryticatus 1 part, 1 part, Semen Armeniacae Amarum, Herba Menthae 1 part, Radix Platycodonis 1 part, Rhizoma Phragmitis 1 part, 1 part, Radix Glycyrrhizae, Fructus Forsythiae 1 part, Periostracum Cicadae 1 part, Radix Puerariae 1 part, Radix Scutellariae 1 part, Bulbus Allii Fistulosi 1 part, except Herba Menthae, Bulbus Allii Fistulosi are separately wrapped and rear lower outside, all medicines are for subsequent use after putting into cloth bag tying;
B, the above-mentioned cloth bag tying mouth put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into marmite, injected the cold boiled water of medicine 35mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water in slag and carry out second time decoction 25 minutes, merge the herb liquid 150 milliliters being condensed into 50%, enter fridge freshness retaining.
A kind of endo-medicine for the treatment of adenovirus pneumonia and preparation method thereof, is characterized in that, described instructions of taking is: divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 25 milliliters/time, taking medicine before meal.Take medicine 4-7 agent, disease obtains recovery from illness.
Medicine provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:
Folium Mori, nature and flavor: bitter in the mouth, sweet, cold in nature, have effect of loose wind heat clearing away, clearing away lung-heat and moistening for dryness, cooling blood for improving eyesight, be used for the treatment of anemopyretic cold, cough due to lung-heat, headache, giddy, conjunctival congestion, dizzy, heat in blood spit blood;
Flos Chrysanthemi, nature and flavor: pungent, sweet, bitter, micro-Huang, has effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances, are used for the treatment of headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling etc.;
Bombyx Batryticatus, nature and flavor: salty, pungent, flat, have effect of expelling wind for relieving convulsion, dissipating phlegm and resolving masses, are used for the treatment of the diseases such as convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes inflammation, facial paralysis;
Semen Armeniacae Amarum, nature and flavor: bitter in the mouth, slightly warm in nature, have effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation, are used for the treatment of that cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin are withered, dryness of the intestine constipation;
Herba Menthae, nature and flavor: acrid in the mouth, cool in nature, there is effect of wind-dispelling heat-dissipating, refresh oneself, throat, rash, resolving depression, be used for the treatment of wind heat table disease, have a headache dizzy, conjunctival congestion and swelling pain, pharyngalgia celostomia, nasal sinusitis, toothache, measles without adequate eruption, urticaria pruritus, the disease such as hypochondriac pain due to stagnation of liverQI gastral cavity is swollen, scrofula tuberculosis;
Radix Platycodonis, nature and flavor: bitter, pungent, flat, have lung qi dispersing, sore-throat relieving, eliminate the phlegm, effect of evacuation of pus, are used for the treatment of cough with copious phlegm, smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus uncomfortable in chest;
Rhizoma Phragmitis, nature and flavor: sweet, cold, there is effect of clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis, be used for the treatment of calentura excessive thirst, gastric heat vomits the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria;
Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong;
Fructus Forsythiae, nature and flavor: bitter in the mouth, cold nature, there is effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, be used for the treatment of anemopyretic cold, epidemic febrile disease swells and ache from the beginning of, scorching larynx, macule, erysipelas, carbuncle knot toxic swelling, tuberculous lymphadenitis, hyperpyrexia excessive thirst, coma send out the diseases such as speckle, scrofula, urinary tract infection;
Periostracum Cicadae, nature and flavor: sweet in the mouth, salty, cold in nature, there is dispelling wind-heat, rash sore-throat relieving, removing nebula to improve visual acuity, the effect of expellingging wind and relieving convulsion, be used for the treatment of anemopyretic cold, laryngopharynx swelling and pain, cough hoarseness, single board computer rash not thoroughly, rubella pruritus, cataract, infantile convulsion twitch, tetanus;
Radix Puerariae, nature and flavor: cool in nature, sweet in the mouth, pungent, having induces sweat brings down a fever, promote the production of body fluid, effect of rash, yang invigorating antidiarrheal, be used for the treatment of fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, to have loose bowels;
Radix Scutellariae, nature and flavor: bitter, cold, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis and antiabortive effect, be used for the treatment of hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tell nosebleed, carbuncle sore tumefacting virus, frequent fetal movement;
Bulbus Allii Fistulosi, nature and flavor: acrid in the mouth, warm in nature, have delivering, activate yang, detoxify, effect of parasite killing, are used for the treatment of cold, YIN-cold stomachache, constipation and anuresis, dysentery, sore, carbuncle and painful swelling, abdominal pain due to worm stagnation.
When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 25 milliliters/time, taking medicine before meal.Take medicine 4-7 agent, disease obtains recovery from illness.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, and hit pathogenesis, has fully demonstrated lung qi dispersing and has dispeled the wind and the pungent Therapeutic Principle shown that cools completely.
Detailed description of the invention
Below embodiments of the present invention are described in detail
The multiple colony of adenovirus pneumonia, adenovirus generally passes through respiratory tract infection.Often there is adenovirus upper respiratory tract infection and pneumonia in collective children mechanism simultaneously.Crowd's serological research illustrates, after raw, the initial several months often retains the adenovirus specific antibody transmitted from parent, ever since to 2 years old antibody deficiency, within 2 years old, just increases gradually later.The clinical observation that this and adenovirus pneumonia 80% occur in 7 ~ 24 months infant meets completely.It should be noted that local each age group Susceptible population quantity is more, the number that adenovirus respiratory tract infection occurs is just many, and the chance of infant generation adenovirus pneumonia is also larger.Adenovirus pneumonia is more common in winter and spring in northern China, and summer, autumn are only accidental, is then more common in autumn in the height in Guangzhou popular year.This parapneumonia accounts for 20% ~ 30% of viral pneumonia in Beijing.
The present invention is exactly treatment for above-mentioned adenovirus pneumonia and a kind of Chinese herbal medicine formula proposed, and adopts herb liquid prepared by this formula, good drug efficacy, instant effect, has no side effect, effectively can treat adenovirus pneumonia.Below specific embodiment provided by the present invention is described in detail.
Embodiment 1:
3 grams, the one-level Folium Mori selecting high-quality clean, Flos Chrysanthemi 3 grams, Bombyx Batryticatus 4.5 grams, 3 grams, Semen Armeniacae Amarum, Herba Menthae 2.1 grams, Radix Platycodonis 2.1 grams, Rhizoma Phragmitis 9 grams, 2.4 grams, Radix Glycyrrhizae, Fructus Forsythiae 3 grams, Periostracum Cicadae 7, Radix Puerariae 3 grams, Radix Scutellariae 2.1 grams, Bulbus Allii Fistulosi 2 cun, except Herba Menthae, Bulbus Allii Fistulosi are separately wrapped and rear lower outside, all medicines are for subsequent use after putting into cloth bag tying; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into marmite, injected the cold boiled water of medicine 35mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water in slag and carry out second time decoction 25 minutes, merge the herb liquid 150 milliliters being condensed into 50%, enter fridge freshness retaining.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 25 milliliters/time, taking medicine before meal.Take medicine 4-7 agent, disease obtains recovery from illness.
Embodiment 2:
3.3 grams, the one-level Folium Mori selecting high-quality clean, Flos Chrysanthemi 3.3 grams, Bombyx Batryticatus 5 grams, 3.3 grams, Semen Armeniacae Amarum, Herba Menthae 2.3 grams, Radix Platycodonis 2.3 grams, Rhizoma Phragmitis 10 grams, 2.6 grams, Radix Glycyrrhizae, Fructus Forsythiae 3.3 grams, Periostracum Cicadae 8, Radix Puerariae 3.3 grams, Radix Scutellariae 2.3 grams, Bulbus Allii Fistulosi 2.5 cun, except Herba Menthae, Bulbus Allii Fistulosi are separately wrapped and rear lower outside, all medicines are for subsequent use after putting into cloth bag tying; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into marmite, injected the cold boiled water of medicine 35mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water in slag and carry out second time decoction 25 minutes, merge the herb liquid 150 milliliters being condensed into 50%, enter fridge freshness retaining.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 25 milliliters/time, taking medicine before meal.Take medicine 4-5 agent, disease obtains recovery from illness.
Embodiment 3:
3 grams, the one-level Folium Mori selecting high-quality clean, Flos Chrysanthemi 3 grams, Bombyx Batryticatus 4.5 grams, 3 grams, Semen Armeniacae Amarum, Herba Menthae 2.1 grams, Radix Platycodonis 2.1 grams, Rhizoma Phragmitis 9 grams, 2.4 grams, Radix Glycyrrhizae, Fructus Forsythiae 3 grams, Periostracum Cicadae 7, Radix Puerariae 3 grams, Radix Scutellariae 2.1 grams, Bulbus Allii Fistulosi 2 cun, except Herba Menthae, Bulbus Allii Fistulosi are separately wrapped and rear lower outside, all medicines are for subsequent use after putting into cloth bag tying; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into marmite, injected the cold boiled water of medicine 35mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water in slag and carry out second time decoction 25 minutes, merge the herb liquid 150 milliliters being condensed into 50%, enter fridge freshness retaining.When taking, divided by the herb liquid prepared and take for two days, the morning, noon and afternoon service once, dosage 25 milliliters/time, taking medicine before meal.Take medicine 4-6 agent, disease obtains recovery from illness.
The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, has no side effect, and part allusion quotation shape case is as follows.
1, patient: Yan XX, man, 10 months, address: Sichuan Province's Deyang City
Illness symptom: in diagnosis and treatment on May 11 in 1996.Infant on inspection, is diagnosed as " adenovirus pneumonia ", high hot six days, body temperature 39.7 DEG C, cough with asthma, and the whole body is sent out has erythra, unease due to fright, oral lesions, cheilosis, and the micro-distension of abdomen, defecates rare, day row 4 times.The floating number of pulse condition is strong, red tongue with a little fluid no fur.This belongs to wind heat and closes lung.Control and should dispel the wind by lung qi dispersing, the pungent table that cools completely.
Treatment: give top " herb liquid " and control it, owing to there being tic million, the auxiliary agent in order to Western medicine calmness.Medication 2 doses, its second dose is removed Radix Puerariae, adds Semen Sojae Preparatum 9g, and after clothes, fever of the body moves back, and cough expectorant subtracts, and erythra is shown in and moves back, drowsy, and do not like to open eyes, stool takes a turn for the better, and number of times reduces, abdomen not distension.The floating number of pulse condition, red tongue with thin fur is white, and tongue lip is still shown in have and festers.Remove Herba Alii fistulosi fermented soya beans, salted or other wise in side, add Folium Eriobotryae (processed) 3g, Radix Peucedani 2.2g.Enter again medicine 2 doses, disease obtains recovery from illness.
2, patient: Guo XX, female, 1 years old, address: Sichuan Province Peng Zhoushi
Illness symptom: father and mother Dai Shu: infant is diagnosed as on inspection " adenovirus pneumonia ", in high hot week, body temperature 39.5 DEG C, cough with asthma, the whole body is sent out has erythra, unease due to fright, oral lesions, and lip is slightly dry and cracked, the micro-distension of abdomen, one day passage of loose stools 3-4 time.The floating number of pulse condition is strong, red tongue with a little fluid no fur.This belongs to wind heat and closes lung.
Treatment: give top " herb liquid " control it, clothes top 2 doses, its second dose is removed Radix Puerariae, adds Semen Sojae Preparatum 8g, and high heat is moved back, cough expectorant subtract, deflorescence, drowsy do not like open eyes, stool is got better, and abdomen is not swollen.The floating number of pulse condition, red tongue with thin fur is white, but tongue lip is still shown in have and festers.Remove Herba Alii fistulosi fermented soya beans, salted or other wise in side, add Folium Eriobotryae (processed) 2.5g, Radix Peucedani 2g.Enter again medicine 2 doses, all diseases are all removed, and fully recover.
3, patient: woods XX, man, 1 years old half, address: Chengdu, Sichuan Province
Illness symptom: gone to a doctor on July 19th, 2000.On inspection, be diagnosed as: adenovirus pneumonia, high hot three days, body temperature 39.3 DEG C, cough with asthma, companion's generalized rass, unease due to fright, oral lesions, lip are slightly dry and cracked, the micro-distension of abdomen, the stool pool are rare, day row 3 times.The floating number of pulse condition is strong, red tongue with a little fluid no fur.
Treatment: give top " herb liquid " and control it, patient has tic million, the agent of auxiliary Western medicine calmness.Clothes top 2 doses, remove Radix Puerariae in its second dose, add Semen Sojae Preparatum 8g, fever of the body moves back, cough expectorant alleviate, erythra obviously disappears, drowsy and do not like open eyes, defecate normal.The floating number of pulse condition, red tongue with thin fur is white, but tongue lip is still shown in have and festers.Remove Herba Alii fistulosi fermented soya beans, salted or other wise in side, add Folium Eriobotryae (processed) 2.5g, Radix Peucedani 2g.Enter again medicine 2 doses, disease is removed and heals.
Claims (3)
1. treat an endo-medicine for adenovirus pneumonia, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Folium Mori 1-3 part;
Flos Chrysanthemi 1-3 part;
Bombyx Batryticatus 1-3 part;
Semen Armeniacae Amarum 1-3 part;
Herba Menthae 1-3 part;
Radix Platycodonis 1-3 part;
Rhizoma Phragmitis 1-3 part;
Radix Glycyrrhizae 1-3 part;
Fructus Forsythiae 1-3 part;
Periostracum Cicadae 1-3 part;
Radix Puerariae 1-3 part;
Radix Scutellariae 1-3 part;
Bulbus Allii Fistulosi 1-3 part.
2. the endo-medicine for the treatment of adenovirus pneumonia according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
1 part, Folium Mori;
Flos Chrysanthemi 1 part;
Bombyx Batryticatus 1 part;
1 part, Semen Armeniacae Amarum;
Herba Menthae 1 part;
Radix Platycodonis 1 part;
Rhizoma Phragmitis 1 part;
1 part, Radix Glycyrrhizae;
Fructus Forsythiae 1 part;
Periostracum Cicadae 1 part;
Radix Puerariae 1 part;
Radix Scutellariae 1 part;
Bulbus Allii Fistulosi 1 part.
3. endo-medicine of the treatment adenovirus pneumonia described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:
A, according to mass parts than selecting the clean one-level Folium Mori of high-quality, Flos Chrysanthemi, Bombyx Batryticatus, Semen Armeniacae Amarum, Herba Menthae, Radix Platycodonis, Rhizoma Phragmitis, Radix Glycyrrhizae, Fructus Forsythiae, Periostracum Cicadae, Radix Puerariae, Radix Scutellariae, Bulbus Allii Fistulosi, except Herba Menthae, Bulbus Allii Fistulosi are separately wrapped and rear lower outside, all medicines are for subsequent use after putting into cloth bag tying;
B, the above-mentioned cloth bag tying mouth put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into marmite, injected the cold boiled water of medicine 35mm, carry out first time decoction 30 minutes, after leaching medicinal liquid, re-inject tepor boiled water in slag and carry out second time decoction 25 minutes, merge the herb liquid 150 milliliters being condensed into 50%, enter fridge freshness retaining.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106798863A (en) * | 2017-03-29 | 2017-06-06 | 卢仁华 | The medicine of adenovirus pneumonia |
CN111569011A (en) * | 2020-05-14 | 2020-08-25 | 贵州神奇药物研究院 | New application of traditional Chinese medicine composition and preparation method thereof |
Citations (1)
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CN1206609A (en) * | 1998-08-12 | 1999-02-03 | 贾培琳 | External medicine for curing respiratory tract disease |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1206609A (en) * | 1998-08-12 | 1999-02-03 | 贾培琳 | External medicine for curing respiratory tract disease |
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Title |
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李文亮等: "《千家妙方》", 28 February 1985 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106798863A (en) * | 2017-03-29 | 2017-06-06 | 卢仁华 | The medicine of adenovirus pneumonia |
CN111569011A (en) * | 2020-05-14 | 2020-08-25 | 贵州神奇药物研究院 | New application of traditional Chinese medicine composition and preparation method thereof |
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Application publication date: 20150624 |