CN105641461A - Traditional Chinese medicine composition treating qi depression fire transforming hyperthyroidism merged self-discipline junctional tachycardia - Google Patents

Abstract

The invention belongs to the technical field of medicine, in particular to a traditional Chinese medicine composition treating qi depression fire transforming hyperthyroidism merged self-discipline junctional tachycardia. The traditional Chinese medicine composition is prepared from following traditional Chinese medicines in parts by weight: 4-8 parts of Flower bud of Japanese apricot, 4-8 parts of jasminum grandiflorum, 4-8 parts of Flos Sophorae, 4-8 parts of common anotis herb, 4-8 parts of large Lathyrus quinquenervius, 4-8 parts of fruit of Manglietia yuyuanensis Law, 4-8 parts of catharanthus roseus, 4-8 parts of Sarcopyramis nepalensis, 4-8 parts of Root of Oblique Rhychoglossum, 4-8 parts of rattlesnake plantain, 4-8 parts of Ganoderma tenue Zhao, Xu et Zhang, 4-8 parts of root of Corylopsis sinensis and 4-8 parts of licorice root. The traditional Chinese medicines are merged to realize effects of soothing liver-qi stagnation, removing heat from the liver and purging intense heat, resolving hard lumps and soothing nerves. The medicine can reduce average heart rate and recover a thyroid function level, has no influence on safety index and is good in safety.

Description

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia.

Background technology

Hyperthyroidism can cause different ARR generation, arrhythmia is sometimes even for the medical symptom and sign occurred the earliest, most of patients is gone to a doctor with arrhythmia for onset symptoms, patient is tachy-arrhythmia, and wherein self-disciplining junctional tachycardia and atrial fibrillation are modal types. Easily there is mistaken diagnosis, fail to pinpoint a disease in diagnosis in hyperthyroid arrhythmia, delay treatment, and primary disease treatment cycle is longer, and symptom is not easily alleviated, and easily recur, such as malpractice or delay treatment, cardiac structure and physiological function can be caused great infringement, even produce irreversibility heart change.

The pathogeny that current doctor trained in Western medicine merges self-disciplining junctional tachycardia for hyperthyroidism still imperfectly understands, and treatment aspect there is no effective Therapeutic Method.

Stagnated QI transforming into fire type is the type that hyperthyroidism merges that self-disciplining junctional tachycardia is common, has not yet to see the medicine being exclusively used in such hyperthyroidism merging self-disciplining junctional tachycardia.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, is made up of the Chinese medicine of following weight portion:

FLOS MUME 4-8 part, Flos Caryophylli Flos jasmini 4-8 part, Flos Sophorae 4-8 part, Herba Anotis ingratae 4-8 part, Herba lathyri davidii 4-8 part, Manglietia yuyuanensis fruit 4-8 part, Herba Catharanthi Rosei 4-8 part, Herba Sarcopyramis nepalensis 4-8 part, Radix Rhynchoglossi Obliqui 4-8 part, Herba goodyearae repentis 4-8 part, ganoderma tenue 4-8 part, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, above-mentioned treatment stagnated QI transforming into fire type hyperthyroidism merges the Chinese medicine composition of self-disciplining junctional tachycardia, is made up of the Chinese medicine of following weight portion:

FLOS MUME 5-7 part, Flos Caryophylli Flos jasmini 5-7 part, Flos Sophorae 5-7 part, Herba Anotis ingratae 5-7 part, Herba lathyri davidii 5-7 part, Manglietia yuyuanensis fruit 5-7 part, Herba Catharanthi Rosei 5-7 part, Herba Sarcopyramis nepalensis 5-7 part, Radix Rhynchoglossi Obliqui 5-7 part, Herba goodyearae repentis 5-7 part, ganoderma tenue 5-7 part, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 5-7 part, Radix Glycyrrhizae 5-7 part.

It is furthermore preferred that above-mentioned treatment stagnated QI transforming into fire type hyperthyroidism merges the Chinese medicine composition of self-disciplining junctional tachycardia, it is made up of the Chinese medicine of following weight portion:

FLOS MUME 6 parts, Flos Caryophylli Flos jasmini 6 parts, 6 parts of Flos Sophorae, Herba Anotis ingratae 6 parts, Herba lathyri davidii 6 parts, Manglietia yuyuanensis fruit 6 parts, Herba Catharanthi Rosei 6 parts, Herba Sarcopyramis nepalensis 6 parts, Radix Rhynchoglossi Obliqui 6 parts, Herba goodyearae repentis 6 parts, ganoderma tenue 6 parts, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 6 parts, 6 parts of Radix Glycyrrhizae.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged.

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for treating stagnated QI transforming into fire type hyperthyroidism and merge self-disciplining junctional tachycardia.

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period.

In the Chinese medicine composition of the present invention,

FLOS MUME derives from Armeniaca Mume of Rosaceae platymiscium FLOS MUME PrunusmumeSieb.etZucc.var.viridicalyxMakino, is used as medicine with flower. Bitter, micro-sweet, flat. Function suppressing the hyperactive liver and easing the stomach. For distending pain in the chest and hypochondrium, stomachache, dyspepsia, neurasthenia.

Flos Caryophylli Flos jasmini derives from Oleaceae Flos Jasmini Sambac platymiscium Flos Caryophylli Flos jasmini JasminumofficinaleL.var.grandiflorum(L.) Kobuski(J.grandiflorumL.), it is used as medicine with alabastrum. Sweet, flat. Function soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain. For hepatitis, hepatalgia, the breast side of body does not relax, heart peratodynia, and dysentery is suffered from abdominal pain.

Flos Sophorae another name gold loblolly tree, Hu Fangshu, bean Chinese scholartree, the Flos Sophorae Immaturus, for the dry flower and alabastrum of leguminous plant Chinese scholartree SophorajaponicaL.. Bitter in the mouth, cold nature. Return liver, large intestine channel. Function cooling blood for hemostasis, purging liver-fire. For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, dizziness of having a headache.

Herba Anotis ingratae another name new grass ear, for the herb of dicotyledon medicine Maguireothamnus speciosus Herba Anotis ingratae Anotisingrata (wall.) Hook.F. [Neanotisyngrata (Wall.exHook.f) W.H.Lewis]. Acrid in the mouth; Cool in nature. GUIXIN; Liver Channel. Function purging liver-fire. Main innominate toxic swelling; Conjunctival congestion is red and swollen; Venom.

Herba lathyri davidii another name Semen Cassiae Sopherae Herba Lathyri quinquenerii, big Semen Pisi sativi. Seed for leguminous plant Semen Cassiae Sopherae sweet pea LathyrusdavidiiHance. Acrid in the mouth; Warm in nature. Return Liver Channel. Function depressed liver-energy dispersing and QI regulating; Menstruction regulating and pain relieving. Main dysmenorrhea; Menoxenia.

Manglietia yuyuanensis fruit calls Fructus Manglietiae fordianae, for the fruit of Magnoliacea plant Manglietia yuyuanensis ManglietiayuyuanensisLaw.. Lightly seasoned; Property is put down. Function depressed liver-energy dispersing and QI regulating; Relieving constipation cough-relieving. Main stomachache due to hyperactive liver-QI attacking the stomach; Distending pain over the hypochondrium; Senile constipation; Cough.

Herba Catharanthi Rosei another name Herba amaranthi tricoloris, everyday new, four time the spring, 30,000 flowers, Folium Lantanae Camarae, everyday spring, four time flower, red Herba Catharanthi Rosei, for apocynaceae plant Herba Catharanthi Rosei Catharanthusroseus(L.) G.Don VincaroseaL. ", Huang Herba Catharanthi Rosei Catharanthusroseus(L.) G.Doncv.Flavus [C.rosea(L.) D.Denvar.FlavusMetcalf "

Herb. Bitter in the mouth; Cold in nature. Return liver; Kidney channel. Function detoxicating and fighting cancer; Heat clearing away suppressing the hyperactive liver. Main multiple cancerous protuberance; Hypertension; Carbuncle sore tumefacting virus; Scald.

Herba Sarcopyramis nepalensis another name FENGDOU is careless, defend Herba Dendrobii, for the herb of Melastomateae plants Herba Sarcopyramis nepalensis SarcopyamisnepalensisWall.. Bitter in the mouth; Sweet; Cold nature. Return lung; Liver Channel. Function heat clearing away suppressing the hyperactive liver; Eliminating damp, detoxifying. Main cough due to lung-heat; The vertigo; Tinnitus; Deaf; Day red photophobia; Hepatitis; Rheumatic arthralgia; Traumatic injury wound is swollen; Snake head-like infection; Innominate toxic swelling.

Radix Rhynchoglossi Obliqui another name string of beads pearl; Half of face, for the whole herb with root of the askew hat Conandron ramondioides sieb. Et zuce RhynchoglossumobliquumBl. of Gesneriaceae. Salty in the mouth; Property is put down. Function hard masses softening and resolving. Main thyromegaly.

Herba goodyearae repentis another name silver wire basin, nine layers of lid, Radix primulae sinodenticulatae, little general, lobule is blue or green, Folium Cannabis is blue or green, Trimeresurus stejnegeri, Agkistrodon medicine, point leaf mountain butterfly, the little green grass or young crops of Folium Bambusae, lung hornwart, Rhizoma pinelliae cordatae, Oxyria sinensis Hemsl., silver earring, for the big Herba goodyearae repentis GoodyeraschlechtendalianaReichb.f. of orchid, little Herba goodyearae repentis goodyerarepens (L.) R.Br. [SatyriumrepensL.], the herb of big piebaldism orchid .Goodyerabifora (Lindl.) Hook.f. [GeorchisbifloraLindl.] or floss tikka aspidistra GoodyeravelutinaMaxim.. sweet in the mouth, pungent, property is put down. function nourishing the lung to arrest cough, tonify Qi of the kidney, promoting flow of QI and blood, subduing swelling and detoxicating. main pulmonary tuberculosis cough, tracheitis, dizzy weak, neurasthenia, sexual impotence, traumatic injury, arthralgia, laryngopharynx swelling and pain, acute mastitis, furuncle, scrofula, venom.

Ganoderma tenue is the sporophore of On Polyporaceae ganoderma tenue GanodermatenueZhao, XuetZhang. Micro-hardship; Temperature. Function mind tranquilizing and the heart calming; Removing toxic substances protects the liver. Main neurasthenia; Cardiopalmus; Insomnia; Acute hepatitis; Chronic hepatitis.

Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root is root or the root bark of Hamamelidaceae Plants China Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) CorylopsissinensisHemsl.. Sweet in the mouth; Property is put down. Return stomach; Heart channel. Function dispelling wind stomach function regulating; Mind tranquilizing and the heart calming. Main diseases caused by exogenous pathogenic factor ailment said due to cold or exposure; Headache; Nausea and vomiting; Cardiopalmus; Dysphoria.

Radix Glycyrrhizae is sweet, flat. GUIXIN, lung, spleen, stomach warp. Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.

Although the traditional Chinese medical science does not have hyperthyroidism to merge the name of disease of self-disciplining junctional tachycardia, but the feature such as become thin according to its throat enlargement, cardiopalmus, excited, aversion to heat hyperhidrosis nervous, irritable, dry mouth and throat, polyphagia, the ownership traditional Chinese medical science " goiter ", " cardiopalmus " category. The present inventor sums up years of work experience, it is believed that primary disease is how relevant with stagnated QI transforming into fire. Therefore with dispersing the stagnated live-QI to relieve the stagnation of QI, the ruling by law of purging liver-fire, hard masses softening and resolving, mind tranquilizing and the heart calming is treated stagnated QI transforming into fire type hyperthyroidism and is merged self-disciplining junctional tachycardia.

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: FLOS MUME, Flos Caryophylli Flos jasmini merit are with dispersing the stagnated live-QI to relieve the stagnation of QI.

Ministerial drug: Flos Sophorae, Herba Anotis ingratae merit are with purging liver-fire.

Adjuvant drug: Herba lathyri davidii, Manglietia yuyuanensis fruit merit is with depressed liver-energy dispersing and QI regulating; Herba Catharanthi Rosei, Herba Sarcopyramis nepalensis merit are with heat clearing away suppressing the hyperactive liver; Radix Rhynchoglossi Obliqui, Herba goodyearae repentis merit are with hard masses softening and resolving; Ganoderma tenue, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root merit are with mind tranquilizing and the heart calming.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays dispersing the stagnated live-QI to relieve the stagnation of QI altogether, purging liver-fire, hard masses softening and resolving, mind tranquilizing and the heart calming method effect. Stagnated QI transforming into fire type hyperthyroidism of linking closely merges the pathogenesis of self-disciplining junctional tachycardia. Improving clinical symptoms, reduce average heart rate, correct the rhythm of the heart, recover thyroid function level, and safety indexes is without impact, safety is good.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, each crude drug weight proportion is as follows:

FLOS MUME 6g, Flos Caryophylli Flos jasmini 6g, Flos Sophorae 6g, Herba Anotis ingratae 6g, Herba lathyri davidii 6g, Manglietia yuyuanensis fruit 6g, Herba Catharanthi Rosei 6g, Herba Sarcopyramis nepalensis 6g, Radix Rhynchoglossi Obliqui 6g, Herba goodyearae repentis 6g, ganoderma tenue 6g, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 6g, Radix Glycyrrhizae 6g.

Embodiment 2

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, each crude drug weight proportion is as follows:

FLOS MUME 5g, Flos Caryophylli Flos jasmini 7g, Flos Sophorae 5g, Herba Anotis ingratae 7g, Herba lathyri davidii 5g, Manglietia yuyuanensis fruit 7g, Herba Catharanthi Rosei 5g, Herba Sarcopyramis nepalensis 7g, Radix Rhynchoglossi Obliqui 5g, Herba goodyearae repentis 7g, ganoderma tenue 5g, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 7g, Radix Glycyrrhizae 5g.

Embodiment 3

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, each crude drug weight proportion is as follows:

FLOS MUME 7g, Flos Caryophylli Flos jasmini 5g, Flos Sophorae 7g, Herba Anotis ingratae 5g, Herba lathyri davidii 7g, Manglietia yuyuanensis fruit 5g, Herba Catharanthi Rosei 7g, Herba Sarcopyramis nepalensis 5g, Radix Rhynchoglossi Obliqui 7g, Herba goodyearae repentis 5g, ganoderma tenue 7g, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 5g, Radix Glycyrrhizae 7g.

Embodiment 4

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, each crude drug weight proportion is as follows:

FLOS MUME 4g, Flos Caryophylli Flos jasmini 8g, Flos Sophorae 4g, Herba Anotis ingratae 8g, Herba lathyri davidii 4g, Manglietia yuyuanensis fruit 8g, Herba Catharanthi Rosei 4g, Herba Sarcopyramis nepalensis 8g, Radix Rhynchoglossi Obliqui 4g, Herba goodyearae repentis 8g, ganoderma tenue 4g, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 8g, Radix Glycyrrhizae 4g.

Embodiment 5

A kind of Chinese medicine composition treating stagnated QI transforming into fire type hyperthyroidism merging self-disciplining junctional tachycardia, each crude drug weight proportion is as follows:

FLOS MUME 8g, Flos Caryophylli Flos jasmini 4g, Flos Sophorae 8g, Herba Anotis ingratae 4g, Herba lathyri davidii 8g, Manglietia yuyuanensis fruit 4g, Herba Catharanthi Rosei 8g, Herba Sarcopyramis nepalensis 4g, Radix Rhynchoglossi Obliqui 8g, Herba goodyearae repentis 4g, ganoderma tenue 8g, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 4g, Radix Glycyrrhizae 8g.

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose hyperthyroidism merge self-disciplining junctional tachycardia (stagnated QI transforming into fire type) patient 130 example, wherein male 44 examples, female 86 example, the mean age (46.94 �� 14.42) year.

1.2 Western medicine diagnose standards

Formulate according to " practical internal medicine " and " inner-sphere reorganization energy ".

1. hyperthyroidism: FT3>7pg/mL, FT4>21pg/mL, TSH<0.35MIU/L.

2. self-disciplining junctional tachycardia: frequency 140��270 beats/min, RR can not definitely hook together; Visible atrioventricular dissociation; It sometimes appear that multiform ventricular tachycardia.

1.3 differential diagnosis in tcm standards

With reference to the diagnostic criteria of " syndrome of qi depression transforming into fire " in " new Chinese medicine guideline of clinical investigations ": primary symptom: palpitation and uneasiness, being irritable and irascible, fullness and distention in the chest and hypochondrium, bitter taste and dryness in the mouth. Secondary disease: throat enlargement, the dry margins of eyelids of eye, headache, conjunctival congestion, tinnitus, or noisy acid regurgitation, constipation. Picture of the tongue pulse condition: red tongue, yellow fur, wiry and frequent pulse. All possess primary symptom and more than two persons of secondary disease, and can make a definite diagnosis with reference to tongue arteries and veins.

1.4 inclusive criterias

1. Informed Consent Form is signed.

2. age 18��70 years old.

3. Chinese and western medicine diagnostic criteria is met.

4. before patient enters group, Zhou Wei takes anxiety depression medicine or antipsychotics.

1.5 exclusion standards

1. age<18 years old or>70 years old patient.

2. gestation or women breast-feeding their children.

3. there are the cardiovascular disease such as acute myocardial infarction, cardiogenic shock, advanced heart failure, severe arrhythmia, merge severe hypertension, severe pulmonary insufficiency, bronchial asthma, hepatic and renal function injure, disease of hematopoietic system or psychotic.

4. the person that has hyperthyroidism crisis.

5. thyroid enlarges markedly and adjacent organs is produced pressure symptom person.

6. various thyroiditiss.

7. use other medications, particularly trial drug is had the medicine (as taken Folium Digitalis Purpureae, potassium salt, turning class and antiarrhythmic drug) of considerable influence, affects effectiveness and safety judgement person.

8. allergic constitution or easy in multi-medicament allergy sufferers.

1.6 cases are rejected and come off standard

1. all cases not meeting inclusive criteria and be strayed into should be rejected;

2. irregular observation measurement or data not umbra sound observation judgement person should reject.

3. in observing, patient bolter voluntarily should be regarded as coming off;

4. occur that adverse events should not continue observer and be considered as coming off in observing.

1.7 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, be decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of.

1.8 treatment fore-and-aft observing indexs

(1) thyroid function: FT3, FT4, TSH.

(2) ambulatory electrocardiogram: record average heart rate, abnormal heart rhythm (such as atrial fibrillation, Fang Zao etc.) number of times and conclusion.

(3) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, it is designated as 0,1,2,3 point respectively.

(4) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit etc.

1.9 arrhythmia curative effect determinate standards

1. effective: cardiopalmus transference cure, heart rate recovered to normal range, and dynamic electrocardiogram illustrates normally or abnormal heart rhythm number of times relatively treats front minimizing more than 74%.

2. effective: cardiopalmus symptom major part disappears, and heart rate drops to less than 100 beats/min, and ambulatory electrocardiogram does not reach arm's length standard, abnormal heart rhythm attack times reduces more than 50% before relatively treating.

3. invalid: cardiopalmus symptom, heart rate and ambulatory electrocardiogram treatment front and back are unchanged or increase the weight of.

1.10 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002.

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: nimodipine method: integration x100% before (before treatment integration after integration-treatment)/treatment.

1.11 statistical method

SPSS14.0 version statistical software is adopted to be analyzed. Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment.

2. result

The 2.1 treatment forward backward averaging rhythms of the heart compare

After treatment, average heart rate is (71.90 �� 4.59) beat/min, relatively (214.25 �� 32.46) beat/min before treatment, hence it is evident that reduce, and difference has statistical significance (t=6.382, P < 0.05).

Thyroid function before and after 2.2 treatments

After treatment, FT3, FT4 substantially reduce before all relatively treating, and TSH relatively treats front significantly raised, and difference has statistical significance (P < 0.05), in Table 1.

Before and after table 1 treatment, thyroid function compares

Time	Number of cases	FT3	FT4	TSH
					Before treatment	130	21.34��2.94	33.54��3.54	0.22��0.15
After treatment	130	3.15��0.58	5.14��1.87	3.22��0.54
					T value	--	5.983	5.596	6.939
P value	--	0.021	0.024	0.013

2.3 arrhythmia curative effects

130 example patient's arrhythmia curative effects: cure 118 examples, effective 7 examples, effective 5 examples, invalid 0 example. Curative effect: cure rate 90.8%, total obvious effective rate 96.2%, total effective rate is 100%.

TCM syndrome integration and TCM syndrome curative effect before and after 2.4 treatments

TCM syndrome total mark (4.67 �� 1.21) point after treatment, relatively (34.32 �� 5.87) before treatment are clearly aobvious reduces, and difference has statistical significance (t=6.583, P < 0.05); 130 example patient's TCM syndrome curative effects: cure 119 examples, effective 9 examples, effective 2 examples, invalid 0 example. Curative effect: cure rate 91.5%, total obvious effective rate 98.5%, total effective rate is 100%.

2.5 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit are without significant change, and drug safety is better.

Claims (3)

1. treat stagnated QI transforming into fire type hyperthyroidism and merge a Chinese medicine composition for self-disciplining junctional tachycardia, be made up of the Chinese medicine of following weight portion:

FLOS MUME 4-8 part, Flos Caryophylli Flos jasmini 4-8 part, Flos Sophorae 4-8 part, Herba Anotis ingratae 4-8 part, Herba lathyri davidii 4-8 part, Manglietia yuyuanensis fruit 4-8 part, Herba Catharanthi Rosei 4-8 part, Herba Sarcopyramis nepalensis 4-8 part, Radix Rhynchoglossi Obliqui 4-8 part, Herba goodyearae repentis 4-8 part, ganoderma tenue 4-8 part, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 4-8 part, Radix Glycyrrhizae 4-8 part.

2. treatment stagnated QI transforming into fire type hyperthyroidism according to claim 1 merges the Chinese medicine composition of self-disciplining junctional tachycardia, it is characterised in that be made up of the Chinese medicine of following weight portion:

FLOS MUME 5-7 part, Flos Caryophylli Flos jasmini 5-7 part, Flos Sophorae 5-7 part, Herba Anotis ingratae 5-7 part, Herba lathyri davidii 5-7 part, Manglietia yuyuanensis fruit 5-7 part, Herba Catharanthi Rosei 5-7 part, Herba Sarcopyramis nepalensis 5-7 part, Radix Rhynchoglossi Obliqui 5-7 part, Herba goodyearae repentis 5-7 part, ganoderma tenue 5-7 part, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 5-7 part, Radix Glycyrrhizae 5-7 part.

3. treatment stagnated QI transforming into fire type hyperthyroidism according to claim 3 merges the Chinese medicine composition of self-disciplining junctional tachycardia, it is characterised in that be made up of the Chinese medicine of following weight portion:

FLOS MUME 6 parts, Flos Caryophylli Flos jasmini 6 parts, 6 parts of Flos Sophorae, Herba Anotis ingratae 6 parts, Herba lathyri davidii 6 parts, Manglietia yuyuanensis fruit 6 parts, Herba Catharanthi Rosei 6 parts, Herba Sarcopyramis nepalensis 6 parts, Radix Rhynchoglossi Obliqui 6 parts, Herba goodyearae repentis 6 parts, ganoderma tenue 6 parts, Cortex corylopsis sinensis radicis (Corylopsis sinensis Hemsl��) root 6 parts, 6 parts of Radix Glycyrrhizae.