CN105687753A - Traditional Chinese medicine composition for treating liver-yin depletion type hyperthyroidism complicating atrial fibrillation - Google Patents

Abstract

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine composition for treating liver-yin depletion type hyperthyroidism complicating atrial fibrillation. The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of fructus corni, 4-8 parts of phoenix hawksbeard roots, 4-8 parts of caragana microphylla roots, 4-8 parts of all grass of balanophora polyandra griff, 4-8 parts of herb of milkywhite pearleverlasting, 4-8 parts of cyrtomioides stegnogramma, 4-8 parts of oriental paperbush flowers, 4-8 parts of fiveleaf akebia fruits, 4-8 parts of herb of creeping rattlesnake plantain, 4-8 parts of celastrus flagellaris Rupr. fruits, 4-8 parts of all grass of ziziphora clinopodioides Lam. and 4-8 parts of liquorice roots. All the medicinal materials are combined to jointly achieve the effects of nourishing yin essence, tonifying the liver and kidney, resolving hardness to dissipate stagnation, and tranquilizing the mind by soothing the heart. The average heart rate can be reduced, the thyroid function level can be recovered, the safety index is not affected, and safety is good.

Description

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation。

Background technology

Hyperthyroidism can cause different ARR generation, arrhythmia is sometimes even for the medical symptom and sign occurred the earliest, most of patients is gone to a doctor with arrhythmia for onset symptoms, and patient is tachy-arrhythmia, and wherein atrial fibrillation and atrial fibrillation are modal types。Easily there is mistaken diagnosis, fail to pinpoint a disease in diagnosis in hyperthyroid arrhythmia, delay treatment, and primary disease treatment cycle is longer, and symptom is not easily alleviated, and easily recur, such as malpractice or delay treatment, cardiac structure and physiological function can be caused great infringement, even produce irreversibility heart change。

The pathogeny that current doctor trained in Western medicine merges atrial fibrillation for hyperthyroidism still imperfectly understands, and treatment aspect there is no effective Therapeutic Method。

Deficiency and exhaustion of liver-YIN type is the type that hyperthyroidism merges that atrial fibrillation is common, has not yet to see the medicine being exclusively used in such hyperthyroidism merging atrial fibrillation。

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation。

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, is made up of the Chinese medicine of following weight portion:

Fructus Corni 4-8 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 4-8 part, Radix Caraganae intermediae 4-8 part, exceedingly high wax candle 4-8 part, Herba Anaphalidis Lacteae 4-8 part, Stegnogramma cyrtomioides (C. Chr.) Ching． 4-8 part, flowers of Edgeworthia chrysantha Lindl 4-8 part, Fructus Akebiae 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part。

Preferably, above-mentioned treatment deficiency and exhaustion of liver-YIN type hyperthyroidism merges the Chinese medicine composition of atrial fibrillation, is made up of the Chinese medicine of following weight portion:

Fructus Corni 5-7 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5-7 part, Radix Caraganae intermediae 5-7 part, exceedingly high wax candle 5-7 part, Herba Anaphalidis Lacteae 5-7 part, Stegnogramma cyrtomioides (C. Chr.) Ching． 5-7 part, flowers of Edgeworthia chrysantha Lindl 5-7 part, Fructus Akebiae 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part。

It is furthermore preferred that above-mentioned treatment deficiency and exhaustion of liver-YIN type hyperthyroidism merges the Chinese medicine composition of atrial fibrillation, it is made up of the Chinese medicine of following weight portion:

Fructus Corni 6 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6 parts, Radix Caraganae intermediae 6 parts, 6 parts of exceedingly high wax candle, Herba Anaphalidis Lacteae 6 parts, Stegnogramma cyrtomioides (C. Chr.) Ching． 6 parts, flowers of Edgeworthia chrysantha Lindl 6 parts, Fructus Akebiae 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged。

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose。

The indication of Chinese medicine of the present invention: be used for treating deficiency and exhaustion of liver-YIN type hyperthyroidism and merge atrial fibrillation。

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period。

In the Chinese medicine composition of the present invention,

Fructus Corni another name Fructus Corni, Fructus Corni, medicine Fructus Jujubae, Fructus Corni。Source is Cornaceae Cornus controversa platymiscium Fructus Corni CornusofficinalisSieb.etZucc., and [Macrocarpiumofficinale (Sieb.EtZucc.) Nakai] is to remove the fruit medicine of seed。Nature and flavor are sour, puckery, tepor。Function liver and kidney tonifying, arresting seminal emission hidroschesis。Have a dizzy spell, deaf, spontaneous perspiration, soreness of the waist and knees, sexual impotence, send essence, frequent micturition。

Crepis crocea Babc.(C.turczaninowii C.A.Mey.) another name Radix Crepidis elongatae, nandina ginseng, Radix Crepidis Ligneae, horse hair ginseng, for the root of outstanding zhang of deep CrepisphoenixDunn of feverfew Folium Bambusae ten thousand。Bitter in the mouth；Sweet；Warm in nature。Function liver and kidney tonifying；Invigorating spleen to remove dampness。Master has a dizzy spell；Soreness of the waist and knees；Edema；Leukorrhagia infantile malnutrition；Hypogalactia。

Radix Caraganae intermediae is the root of leguminous plant Caragana intermedia CaraganaintermediaKuangetH.C.Fu。Taste is micro-pungent；Warm in nature。GUIXIN；Liver Channel。Function supplementing QI and nourishing YIN。Main dizziness, cardiopalmus, shortness of breath and fatigue, hypertension。

Exceedingly high wax candle another name timber fungus Herba Cistanches, native, for the herb of Balanophoraceae plant Herba Balanophorae polyandrae BalanophorapolyandraGriff. ［ Poly-plethiapolyandra (Griff.) vanTiegh. ］。Bitter in the mouth；Micro-puckery；Property is put down。Function heat-clearing and toxic substances removing；Nourishing YIN and benefiting blood；Hemostasis。Main gonorrhea；Syphilis；Blood deficiency；Hemorrhage。

Herba Anaphalidis Lacteae another name DABAI lance lance Artemisia argyi fragrant, big, derives from Compositae Herba Anaphalidis Lacteae AnaphalislacteaMaxim., with all herbal medicine。Acrid in the mouth, hardship, cold in nature。Function promoting blood circulation to remove blood stasis, suppressing the hyperactive liver and subsiding YANG, eliminates the phlegm。External is stopped blooding。Cure mainly blood stasis enclosed mass, excessive rising of liver-YANG, cough due to lung-heat, wound hemorrhage。

Stegnogramma cyrtomioides (C. Chr.) Ching． another name breast chicken rattan, doggie Ovum Gallus domesticus, for the rhizome of Thelypteridaceae plant Stegnogramma cyrtomioides (C. Chr.) Ching． Stegnogrammacyrtomioides (C.Chr) Ching [Dryopterisstegnogramma (Bl.) C.Chr.var.cyrtomioidesC.Chr.]。Sweet in the mouth；Bitter；Cold in nature。Return Liver Channel。Function suppressing the hyperactive liver and subsiding YANG。Main dizziness；Vexed insomnia；Night sweat。

Flowers of Edgeworthia chrysantha Lindl another name gold gum bag, knotting flower, dream Flos Farfarae, happiness flower, for the alabastrum of Isolated From Thymelaeaceae Species Edgeworthia chrysantha Lindl. EdgeworthiachrysanthaLindl.。Property is put down, lightly seasoned。Function yin nourishing is calmed the nerves, and improving eyesight is dispelled and hidden from view。For optic atrohic blindness, cataracta, many tear, nocturnal emission, empty pouring, aphonia。

Fructus Akebiae another name poultry, take son, small wooden raft, cover son, August short, bristly hair or beard, Caulis Akebiae son, son of helping get over a shock, Fructus Akebiae, Fructus Akebiae, August be fried, August fruit, one hundred days melon, lead rattan melon, cold rice packet, draw really, open country perfume friendship, YANGKAIKOU, cured melon。Mature fruit for plants of Lardizabalaceae Caulis Akebiae Akebiaquinata (Thunb.) Decne, threeleaf akebia A.trifoliata (Thunb.) Koidz.var.australis (Dies) .Rehd.。Hiding micro-hardship, property is put down。Return liver, stomach, bladder warp。Return liver；Stomach warp。Function dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis。Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor。

Herba goodyearae repentis another name silver wire basin, nine layers of lid, Radix primulae sinodenticulatae, little general, lobule is blue or green, Folium Cannabis is blue or green, Trimeresurus stejnegeri, Agkistrodon medicine, point leaf mountain butterfly, the little green grass or young crops of Folium Bambusae, lung hornwart, Rhizoma pinelliae cordatae, Oxyria sinensis Hemsl., silver earring, for the big Herba goodyearae repentis GoodyeraschlechtendalianaReichb.f. of orchid, little Herba goodyearae repentis goodyerarepens (L.) R.Br. [SatyriumrepensL.], the herb of big piebaldism orchid .Goodyerabifora (Lindl.) Hook.f. [GeorchisbifloraLindl.] or floss tikka aspidistra GoodyeravelutinaMaxim.。Sweet in the mouth；Pungent；Property is put down。Function nourishing the lung to arrest cough；Tonify Qi of the kidney；Promoting flow of QI and blood；Subduing swelling and detoxicating。Main pulmonary tuberculosis cough；Tracheitis；Dizzy weak；Neurasthenia；Sexual impotence；Traumatic injury；Arthralgia；Laryngopharynx swelling and pain；Acute mastitis；Furuncle；Scrofula；Venom。

Thorn bud fruits of Celastrus orbiculatus Thunb is the fruit of Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr.。Bitter in the mouth；Pungent；Property is put down。Function mind tranquilizing and the heart calming；Activating collaterals to relieve pain；Removing toxic substances and promoting subsidence of swelling。Main palpitation and insomnia；Bones and muscles pain；Waist-leg is numb；Toothache；Sore swollen toxin。

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali, for the Herb of labiate lip Rhizoma et radix valerianae ZiziphoraclinopodioidesLam.。Acrid in the mouth；Cool in nature。Function mind tranquilizing and the heart calming；Diuretic heat clearing away。Main cardiopalmus；Insomnia；Edema；Cold, fever；Conjunctival congestion and swelling pain；Sore swollen toxin。

Radix Glycyrrhizae is sweet, flat。GUIXIN, lung, spleen, stomach warp。Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。

Although the traditional Chinese medical science does not have hyperthyroidism to merge the name of disease of atrial fibrillation, but the feature such as become thin according to its throat enlargement, cardiopalmus, excited, aversion to heat hyperhidrosis nervous, irritable, dry mouth and throat, polyphagia, the ownership traditional Chinese medical science " goiter ", " cardiopalmus " category。The present inventor sums up years of work experience, it is believed that primary disease is how relevant with deficiency and exhaustion of liver-YIN。Therefore with nourishing essence, liver and kidney tonifying, hard masses softening and resolving, mind tranquilizing and the heart calming ruling by law is treated deficiency and exhaustion of liver-YIN type hyperthyroidism and is merged atrial fibrillation。

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: Fructus Corni, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) merit are with liver and kidney tonifying。

Ministerial drug: Radix Caraganae intermediae, exceedingly high wax candle merit are with nourishing YIN and benefiting blood。

Adjuvant drug: Herba Anaphalidis Lacteae, Stegnogramma cyrtomioides (C. Chr.) Ching． merit are with suppressing the hyperactive liver and subsiding YANG；Fructus Akebiae, Herba goodyearae repentis merit are with hard masses softening and resolving；Flowers of Edgeworthia chrysantha Lindl merit is calmed the nerves with yin nourishing；Thorn bud fruits of Celastrus orbiculatus Thunb, lip Rhizoma et radix valerianae merit are with mind tranquilizing and the heart calming。

Make medicine: Radix Glycyrrhizae merit is with easing up the urgency with moist and sweet drugs, coordinating the actions of various ingredients in a prescription。

We's compatibility is reasonable, and all medicines share and play nourishing essence altogether, liver and kidney tonifying, hard masses softening and resolving, the effect of mind tranquilizing and the heart calming。Deficiency and exhaustion of liver-YIN type hyperthyroidism of linking closely merges the pathogenesis of atrial fibrillation。Improving clinical symptoms, reduce average heart rate, turn multiple sinus rhythm, recover thyroid function level, and safety indexes is without impact, safety is good。

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention。

Embodiment 1

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Fructus Corni 6g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6g, Radix Caraganae intermediae 6g, exceedingly high wax candle 6g, Herba Anaphalidis Lacteae 6g, Stegnogramma cyrtomioides (C. Chr.) Ching． 6g, flowers of Edgeworthia chrysantha Lindl 6g, Fructus Akebiae 6g, Herba goodyearae repentis 6g, thorn bud fruits of Celastrus orbiculatus Thunb 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g。

Embodiment 2

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Fructus Corni 5g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 7g, Radix Caraganae intermediae 5g, exceedingly high wax candle 7g, Herba Anaphalidis Lacteae 5g, Stegnogramma cyrtomioides (C. Chr.) Ching． 7g, flowers of Edgeworthia chrysantha Lindl 5g, Fructus Akebiae 5g, Herba goodyearae repentis 7g, thorn bud fruits of Celastrus orbiculatus Thunb 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g。

Embodiment 3

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Fructus Corni 7g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5g, Radix Caraganae intermediae 7g, exceedingly high wax candle 5g, Herba Anaphalidis Lacteae 7g, Stegnogramma cyrtomioides (C. Chr.) Ching． 5g, flowers of Edgeworthia chrysantha Lindl 7g, Fructus Akebiae 7g, Herba goodyearae repentis 5g, thorn bud fruits of Celastrus orbiculatus Thunb 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g。

Embodiment 4

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Fructus Corni 4g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 8g, Radix Caraganae intermediae 4g, exceedingly high wax candle 8g, Herba Anaphalidis Lacteae 4g, Stegnogramma cyrtomioides (C. Chr.) Ching． 8g, flowers of Edgeworthia chrysantha Lindl 4g, Fructus Akebiae 4g, Herba goodyearae repentis 8g, thorn bud fruits of Celastrus orbiculatus Thunb 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g。

Embodiment 5

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Fructus Corni 8g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 4g, Radix Caraganae intermediae 8g, exceedingly high wax candle 4g, Herba Anaphalidis Lacteae 8g, Stegnogramma cyrtomioides (C. Chr.) Ching． 4g, flowers of Edgeworthia chrysantha Lindl 8g, Fructus Akebiae 8g, Herba goodyearae repentis 4g, thorn bud fruits of Celastrus orbiculatus Thunb 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g。

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose hyperthyroidism merge atrial fibrillation (deficiency and exhaustion of liver-YIN type) patient 140 example, wherein male 46 examples, female 94 example, the mean age (46.25 ± 12.27) year。

1.2 Western medicine diagnose standards

Formulate according to " practical internal medicine " and " inner-sphere reorganization energy "。

1. hyperthyroidism: FT3>7pg/mL, FT4>21pg/mL, TSH<0.35MIU/L。

2. atrial fibrillation: P ripple disappears, and f wave (f ripple) occurs, and frequency 350～650 beats/min, R-R spacing is absolutely not regular。

1.3 differential diagnosis in tcm standards

With reference to the diagnostic criteria of " deficiency and exhaustion of liver-YIN card " in " new Chinese medicine guideline of clinical investigations ": primary symptom: cardiopalmus, irritable emotion, being irritable and getting angry easily, dizziness, tinnitus。Secondary disease: throat enlargement, order does photophobia, fuzzy viewing, or headache and swollen, flushing conjunctival congestion。Picture of the tongue pulse condition: dry tongue is red, stringy and thready pulse or number。All possess primary symptom and more than two persons of secondary disease, and can make a definite diagnosis with reference to tongue arteries and veins。

1.4 inclusive criterias

1. Informed Consent Form is signed。

2. age 18～70 years old。

3. Chinese and western medicine diagnostic criteria is met。

4. patient enter group within first 2 weeks, do not take anxiety depression medicine or antipsychotics。

1.5 exclusion standards

1. age<18 years old or>70 years old patient。

2. gestation or women breast-feeding their children。

3. there are the cardiovascular disease such as acute myocardial infarction, cardiogenic shock, advanced heart failure, severe arrhythmia, merge severe hypertension, severe pulmonary insufficiency, bronchial asthma, hepatic and renal function injure, disease of hematopoietic system or psychotic。

4. the person that has hyperthyroidism crisis。

5. thyroid enlarges markedly and adjacent organs is produced pressure symptom person。

6. various thyroiditiss。

7. use other medications, particularly trial drug is had the medicine (as taken Folium Digitalis Purpureae, potassium salt, turning class and antiarrhythmic drug) of considerable influence, affects effectiveness and safety judgement person。

8. allergic constitution or easy in multi-medicament allergy sufferers。

1.6 cases are rejected and come off standard

1. all cases not meeting inclusive criteria and be strayed into should be rejected；

2. irregular observation measurement or data not umbra sound observation judgement person should reject。

3. in observing, patient bolter voluntarily should be regarded as coming off；

4. occur that adverse events should not continue observer and be considered as coming off in observing。

1.7 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, be decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of。

1.8 treatment fore-and-aft observing indexs

(1) thyroid function: FT3, FT4, TSH。

(2) ambulatory electrocardiogram: record average heart rate, abnormal heart rhythm (such as atrial fibrillation, Fang Zao etc.) number of times and conclusion。

(3) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, it is designated as 0,1,2,3 point respectively。

(4) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit etc.。

1.9 arrhythmia curative effect determinate standards

1. effective: cardiopalmus transference cure, heart rate recovered to normal range, and dynamic electrocardiogram illustrates normally or abnormal heart rhythm number of times relatively treats front minimizing more than 74%。

2. effective: cardiopalmus symptom major part disappears, and heart rate drops to less than 100 beats/min, and ambulatory electrocardiogram does not reach arm's length standard, abnormal heart rhythm attack times reduces more than 50% before relatively treating。

3. invalid: cardiopalmus symptom, heart rate and ambulatory electrocardiogram treatment front and back are unchanged or increase the weight of。

1.10 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002。

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%;

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%;

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%;

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%。

Computing formula: nimodipine method: integration x100% before (before treatment integration after integration-treatment)/treatment。

1.11 statistical method

SPSS14.0 version statistical software is adopted to be analyzed。Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment。

2. result

The 2.1 treatment forward backward averaging rhythms of the heart compare

After treatment, average heart rate is (75.46 ± 5.62) beat/min, relatively (345.92 ± 46.53) beat/min before treatment, hence it is evident that reduce, and difference has statistical significance (t=6.495, P < 0.05)。

Thyroid function before and after 2.2 treatments

After treatment, FT3, FT4 substantially reduce before all relatively treating, and TSH relatively treats front significantly raised, and difference has statistical significance (P < 0.05), in Table 1。

Before and after table 1 treatment, thyroid function compares

Time	Number of cases	FT3	FT4	TSH
					Before treatment	140	19.84±3.24	32.61±3.67	0.21±0.14 5 -->
After treatment	140	3.12±0.51	4.98±1.22	3.52±0.52
					T value	--	5.987	5.874	6.159
P value	--	0.019	0.022	0.016

2.3 arrhythmia curative effects

140 example patient's arrhythmia curative effects: cure 128 examples, effective 9 examples, effective 3 examples, invalid 0 example。Curative effect: cure rate 91.4%, total obvious effective rate 97.9%, total effective rate is 100%。

TCM syndrome integration and TCM syndrome curative effect before and after 2.4 treatments

TCM syndrome total mark (5.02 ± 1.17) point after treatment, relatively (34.32 ± 5.76) before treatment are clearly aobvious reduces, and difference has statistical significance (t=5.876, P < 0.05)；140 example patient's TCM syndrome curative effects: cure 129 examples, effective 10 examples, effective 1 example, invalid 0 example。Curative effect: cure rate 92.1%, total obvious effective rate 99.3%, total effective rate is 100%。

2.5 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit are without significant change, and drug safety is better。

Claims (3)

1. treat deficiency and exhaustion of liver-YIN type hyperthyroidism and merge a Chinese medicine composition for atrial fibrillation, be made up of the Chinese medicine of following weight portion:

Fructus Corni 4-8 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 4-8 part, Radix Caraganae intermediae 4-8 part, exceedingly high wax candle 4-8 part, Herba Anaphalidis Lacteae 4-8 part, Stegnogramma cyrtomioides (C. Chr.) Ching． 4-8 part, flowers of Edgeworthia chrysantha Lindl 4-8 part, Fructus Akebiae 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part。

2. treatment deficiency and exhaustion of liver-YIN type hyperthyroidism according to claim 1 merges the Chinese medicine composition of atrial fibrillation, it is characterised in that be made up of the Chinese medicine of following weight portion:

Fructus Corni 5-7 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5-7 part, Radix Caraganae intermediae 5-7 part, exceedingly high wax candle 5-7 part, Herba Anaphalidis Lacteae 5-7 part, Stegnogramma cyrtomioides (C. Chr.) Ching． 5-7 part, flowers of Edgeworthia chrysantha Lindl 5-7 part, Fructus Akebiae 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part。

3. treatment deficiency and exhaustion of liver-YIN type hyperthyroidism according to claim 3 merges the Chinese medicine composition of atrial fibrillation, it is characterised in that be made up of the Chinese medicine of following weight portion:

Fructus Corni 6 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6 parts, Radix Caraganae intermediae 6 parts, 6 parts of exceedingly high wax candle, Herba Anaphalidis Lacteae 6 parts, Stegnogramma cyrtomioides (C. Chr.) Ching． 6 parts, flowers of Edgeworthia chrysantha Lindl 6 parts, Fructus Akebiae 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。