CN105687755A - Traditional Chinese medicine composition for treating blood circulation stasis type hyperthyreosis with atrial fibrillation - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating blood circulation stasis type hyperthyreosis with atrial fibrillation. The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of huechys sanguinea de geer, 4-8 parts of bark of ulmus pumila L. var. pilosa Rehd, 4-8 parts of flower buds of jasminum officinale L. var., 4-8 parts of flowers of prunus mume Sieb. et Zucc. var. viridicalyx Makino, 4-8 parts of seeds of lathycus davidii david vetchling, 4-8 parts of fruit of manglietia yuyuanensis law, 4-8 parts of pericarp of common sterculia, 4-8 parts of root-bark of spinystem aralia, 4-8 parts of herb of rhynchoglossum obliquum Bl., 4-8 parts of herb of goodyera schlechtendaliana Reichb.f., 4-8 parts of fruit of celastrus flagellaris Rupr., 4-8 parts of herb of ziziphora clinopodioides Lam. and 4-8 parts of licorice roots. All the medicine materials are cooperatively used to jointly achieve the effects of promoting blood circulation to remove blood stasis, regulating qi to resolve depression, softening hardness to dissipate stagnation, calming the mind and soothing the nerves. The average heart rate can be lowered, the thyroid function level can be recovered, no influence is generated on the safety indexes, and the safety is good.

Description

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation。

Background technology

Hyperthyroidism can cause different ARR generation, arrhythmia is sometimes even for the medical symptom and sign occurred the earliest, most of patients is gone to a doctor with arrhythmia for onset symptoms, and patient is tachy-arrhythmia, and wherein atrial fibrillation and atrial fibrillation are modal types。Easily there is mistaken diagnosis, fail to pinpoint a disease in diagnosis in hyperthyroid arrhythmia, delay treatment, and primary disease treatment cycle is longer, and symptom is not easily alleviated, and easily recur, such as malpractice or delay treatment, cardiac structure and physiological function can be caused great infringement, even produce irreversibility heart change。

The pathogeny that current doctor trained in Western medicine merges atrial fibrillation for hyperthyroidism still imperfectly understands, and treatment aspect there is no effective Therapeutic Method。

Blood stasis type is the type that hyperthyroidism merges that atrial fibrillation is common, has not yet to see the medicine being exclusively used in such hyperthyroidism merging atrial fibrillation。

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation。

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, is made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 4-8 part, Cortex Ulmi virgatae 4-8 part, Flos Caryophylli Flos jasmini 4-8 part, FLOS MUME 4-8 part, Herba lathyri davidii 4-8 part, Manglietia yuyuanensis fruit 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, redwood 4-8 part, Radix Rhynchoglossi Obliqui 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part。

Preferably, above-mentioned treatment blood stasis type hyperthyroidism merges the Chinese medicine composition of atrial fibrillation, is made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 5-7 part, Cortex Ulmi virgatae 5-7 part, Flos Caryophylli Flos jasmini 5-7 part, FLOS MUME 5-7 part, Herba lathyri davidii 5-7 part, Manglietia yuyuanensis fruit 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, redwood 5-7 part, Radix Rhynchoglossi Obliqui 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part。

It is furthermore preferred that above-mentioned treatment blood stasis type hyperthyroidism merges the Chinese medicine composition of atrial fibrillation, it is made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 6 parts, Cortex Ulmi virgatae 6 parts, Flos Caryophylli Flos jasmini 6 parts, FLOS MUME 6 parts, Herba lathyri davidii 6 parts, Manglietia yuyuanensis fruit 6 parts, Pericarpium Sterculiae nobilis 6 parts, redwood 6 parts, Radix Rhynchoglossi Obliqui 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged。

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose。

The indication of Chinese medicine of the present invention: be used for treating blood stasis type hyperthyroidism and merge atrial fibrillation。

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period。

In the Chinese medicine composition of the present invention,

Huechys sanguinea De Geer. another name Epicauta gorhami, red female, Calyx Seu Fructus Physalis, YAOGUCHONG, ash are spent moth, are spent big chicken, Gallus jabouillei waist, red lid worm, derive from cicada Huechys sanguinea HuechyssanguineaDeGeer or the dry polypide of brown wing Huechys sanguinea De Geer. H.philaemataFabricius。Bitter in the mouth, property is put down。Function blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens。For blood stasis amenorrhea, tuberculous lymphadenitis, lyssodexis；Scabies skin infection is controlled in external。

Cortex Ulmi virgatae another name Radix Ulmi Tonkinesis, for Ulmaceae hair elm UlmusadrossowiiLitw.var.virgata (Planch.) Grudz. [U.virgataWall.exPlanch.;U.PumilaL.var.pilosaRehd.] bark。Bitter in the mouth；Puckery；Property is put down。Function blood circulation promoting and blood stasis dispelling；Hemostasis and pain-relieving。Main fracture；Traumatic pain；Traumatic hemorrhage；Gastrointestinal hemorrhage；Hematuria。

Flos Caryophylli Flos jasmini derives from Oleaceae Flos Jasmini Sambac platymiscium Flos Caryophylli Flos jasmini JasminumofficinaleL.var.grandiflorum(L.) Kobuski(J.grandiflorumL.), it is used as medicine with alabastrum。Sweet, flat。Function soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain。For hepatitis, hepatalgia, the breast side of body does not relax, heart peratodynia, and dysentery is suffered from abdominal pain。

FLOS MUME derives from Armeniaca Mume of Rosaceae platymiscium FLOS MUME PrunusmumeSieb.etZucc.var.viridicalyxMakino, is used as medicine with flower。Bitter, micro-sweet, flat。Function suppressing the hyperactive liver and easing the stomach。For distending pain in the chest and hypochondrium, stomachache, dyspepsia, neurasthenia。

Herba lathyri davidii another name Semen Cassiae Sopherae Herba Lathyri quinquenerii, big Semen Pisi sativi。Seed for leguminous plant Semen Cassiae Sopherae sweet pea LathyrusdavidiiHance。Acrid in the mouth；Warm in nature。Return Liver Channel。Function depressed liver-energy dispersing and QI regulating；Menstruction regulating and pain relieving。Main dysmenorrhea；Menoxenia。

Manglietia yuyuanensis fruit calls Fructus Manglietiae fordianae, for the fruit of Magnoliacea plant Manglietia yuyuanensis ManglietiayuyuanensisLaw.。Lightly seasoned；Property is put down。Function depressed liver-energy dispersing and QI regulating；Relieving constipation cough-relieving。Main stomachache due to hyperactive liver-QI attacking the stomach；Distending pain over the hypochondrium；Senile constipation；Cough。

Pericarpium Sterculiae nobilis another name Semen Sterculiae Nobilis pod, sterculia nobilis's shell。Shell for Sterculiaceae plant sterculia nobilis SterculianobilisSmith。Sweet in the mouth；Property is put down。Return small intestine meridian。Function blood-activating and qi-promoting。Main dysentery；Inguinal hernia；Hemorrhoid；Otitis media。

Redwood calls red Herba Damnacanthi, llex cornuta, HONGCI cylinder, red Ramulus Kalopanacis seu Araliae, red burr paulownia, red llex cornuta thorn, HONGCI paulownia, tiger green pepper thorn, thousand pieces of pins, the big cat thorn of red autumnal leaves, red autumnal leaves umbrella thorn, HONGCI party, thorn stem wood, for root and the root bark of Araliaceae spine stem wood AraliaechinocaulisHand.-Mazz.。Mildly bitter flavor；Pungent；Property is put down。Function expelling wind and removing dampness；Blood-activating and qi-promoting；Removing toxic substances and promoting subsidence of swelling。Main air pain of dampness syndrome；Treating swelling and pain by traumatic injury；Fracture；Epigastric distending pain；Hernia；Metrorrhagia；Osteomyelitis；Carbuncle；Venom。

Radix Rhynchoglossi Obliqui another name string of beads pearl；Half of face, for the whole herb with root of the askew hat Conandron ramondioides sieb. Et zuce RhynchoglossumobliquumBl. of Gesneriaceae。Salty in the mouth；Property is put down。Function hard masses softening and resolving。Main thyromegaly。

Herba goodyearae repentis another name silver wire basin, nine layers of lid, Radix primulae sinodenticulatae, little general, lobule is blue or green, Folium Cannabis is blue or green, Trimeresurus stejnegeri, Agkistrodon medicine, point leaf mountain butterfly, the little green grass or young crops of Folium Bambusae, lung hornwart, Rhizoma pinelliae cordatae, Oxyria sinensis Hemsl., silver earring, for the big Herba goodyearae repentis GoodyeraschlechtendalianaReichb.f. of orchid, little Herba goodyearae repentis goodyerarepens (L.) R.Br. [SatyriumrepensL.], the herb of big piebaldism orchid .Goodyerabifora (Lindl.) Hook.f. [GeorchisbifloraLindl.] or floss tikka aspidistra GoodyeravelutinaMaxim.。Sweet in the mouth；Pungent；Property is put down。Function nourishing the lung to arrest cough；Tonify Qi of the kidney；Promoting flow of QI and blood；Subduing swelling and detoxicating。Main pulmonary tuberculosis cough；Tracheitis；Dizzy weak；Neurasthenia；Sexual impotence；Traumatic injury；Arthralgia；Laryngopharynx swelling and pain；Acute mastitis；Furuncle；Scrofula；Venom。

Thorn bud fruits of Celastrus orbiculatus Thunb is the fruit of Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr.。Bitter in the mouth；Pungent；Property is put down。Function mind tranquilizing and the heart calming；Activating collaterals to relieve pain；Removing toxic substances and promoting subsidence of swelling。Main palpitation and insomnia；Bones and muscles pain；Waist-leg is numb；Toothache；Sore swollen toxin。

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali, for the Herb of labiate lip Rhizoma et radix valerianae ZiziphoraclinopodioidesLam.。Acrid in the mouth；Cool in nature。Function mind tranquilizing and the heart calming；Diuretic heat clearing away。Main cardiopalmus；Insomnia；Edema；Cold, fever；Conjunctival congestion and swelling pain；Sore swollen toxin。

Radix Glycyrrhizae is sweet, flat。GUIXIN, lung, spleen, stomach warp。Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。

Although the traditional Chinese medical science does not have hyperthyroidism to merge the name of disease of atrial fibrillation, but the feature such as become thin according to its throat enlargement, cardiopalmus, excited, aversion to heat hyperhidrosis nervous, irritable, dry mouth and throat, polyphagia, the ownership traditional Chinese medical science " goiter ", " cardiopalmus " category。The present inventor sums up years of work experience, it is believed that primary disease is how relevant with blood stasis。Therefore with blood circulation promoting and blood stasis dispelling, the ruling by law of resolving depression of regulating the flow of vital energy, hard masses softening and resolving, mind tranquilizing and the heart calming is treated blood stasis type hyperthyroidism and is merged atrial fibrillation。

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: Huechys sanguinea De Geer., Cortex Ulmi virgatae merit are with blood circulation promoting and blood stasis dispelling。

Ministerial drug: FLOS MUME, Flos Caryophylli Flos jasmini merit are with dispersing the stagnated live-QI to relieve the stagnation of QI。

Adjuvant drug: Herba lathyri davidii, Manglietia yuyuanensis fruit merit is with depressed liver-energy dispersing and QI regulating；Pericarpium Sterculiae nobilis, redwood merit are with blood-activating and qi-promoting；Radix Rhynchoglossi Obliqui, Herba goodyearae repentis merit are with hard masses softening and resolving；Thorn bud fruits of Celastrus orbiculatus Thunb, lip Rhizoma et radix valerianae merit are with mind tranquilizing and the heart calming。

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription。

We's compatibility is reasonable, and all medicines share plays blood circulation promoting and blood stasis dispelling altogether, resolving depression of regulating the flow of vital energy, hard masses softening and resolving, mind tranquilizing and the heart calming effect。The blood that links closely stasis type hyperthyroidism merges the pathogenesis of atrial fibrillation。Improving clinical symptoms, reduce average heart rate, correct the rhythm of the heart, recover thyroid function level, and safety indexes is without impact, safety is good。

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention。

Embodiment 1

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Huechys sanguinea De Geer. 6g, Cortex Ulmi virgatae 6g, Flos Caryophylli Flos jasmini 6g, FLOS MUME 6g, Herba lathyri davidii 6g, Manglietia yuyuanensis fruit 6g, Pericarpium Sterculiae nobilis 6g, redwood 6g, Radix Rhynchoglossi Obliqui 6g, Herba goodyearae repentis 6g, thorn bud fruits of Celastrus orbiculatus Thunb 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g。

Embodiment 2

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Huechys sanguinea De Geer. 7g, Cortex Ulmi virgatae 5g, Flos Caryophylli Flos jasmini 7g, FLOS MUME 5g, Herba lathyri davidii 7g, Manglietia yuyuanensis fruit 5g, Pericarpium Sterculiae nobilis 7g, redwood 5g, Radix Rhynchoglossi Obliqui 5g, Herba goodyearae repentis 7g, thorn bud fruits of Celastrus orbiculatus Thunb 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g。

Embodiment 3

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Huechys sanguinea De Geer. 5g, Cortex Ulmi virgatae 7g, Flos Caryophylli Flos jasmini 5g, FLOS MUME 7g, Herba lathyri davidii 5g, Manglietia yuyuanensis fruit 7g, Pericarpium Sterculiae nobilis 5g, redwood 7g, Radix Rhynchoglossi Obliqui 7g, Herba goodyearae repentis 5g, thorn bud fruits of Celastrus orbiculatus Thunb 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g。

Embodiment 4

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Huechys sanguinea De Geer. 8g, Cortex Ulmi virgatae 4g, Flos Caryophylli Flos jasmini 8g, FLOS MUME 4g, Herba lathyri davidii 8g, Manglietia yuyuanensis fruit 4g, Pericarpium Sterculiae nobilis 8g, redwood 4g, Radix Rhynchoglossi Obliqui 4g, Herba goodyearae repentis 8g, thorn bud fruits of Celastrus orbiculatus Thunb 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g。

Embodiment 5

A kind of Chinese medicine composition treating blood stasis type hyperthyroidism merging atrial fibrillation, each crude drug weight proportion is as follows:

Huechys sanguinea De Geer. 4g, Cortex Ulmi virgatae 8g, Flos Caryophylli Flos jasmini 4g, FLOS MUME 8g, Herba lathyri davidii 4g, Manglietia yuyuanensis fruit 8g, Pericarpium Sterculiae nobilis 4g, redwood 8g, Radix Rhynchoglossi Obliqui 8g, Herba goodyearae repentis 4g, thorn bud fruits of Celastrus orbiculatus Thunb 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g。

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose hyperthyroidism merge atrial fibrillation (blood stasis type) patient 140 example, wherein male 55 examples, female 85 example, the mean age (45.54 ± 12.34) year。

1.2 Western medicine diagnose standards

Formulate according to " practical internal medicine " and " inner-sphere reorganization energy "。

1. hyperthyroidism: FT3>7pg/mL, FT4>21pg/mL, TSH<0.35MIU/L。

2. atrial fibrillation: P ripple disappears, and f wave (f ripple) occurs, and frequency 350～600 beats/min, R-R spacing is absolutely not regular。

1.3 differential diagnosis in tcm standards

With reference to the diagnostic criteria of " blood stasis card " in " new Chinese medicine guideline of clinical investigations ": primary symptom: palpitation and uneasiness, spirit depressing, irascible temperament, headache, or pain in chest and hypochondrium。Secondary disease: throat enlargement, the dry margins of eyelids of eye, insomnia, forgetful, or there is sense of feeling cold or generate heat in health portion。Picture of the tongue pulse condition: purplish tongue, or have petechia, ecchymosis, stringy pulse or puckery。All possess primary symptom and more than two persons of secondary disease, and can make a definite diagnosis with reference to tongue arteries and veins。

1.4 inclusive criterias

1. Informed Consent Form is signed。

2. age 18～70 years old。

3. Chinese and western medicine diagnostic criteria is met。

4. before patient enters group, Zhou Wei takes anxiety depression medicine or antipsychotics。

1.5 exclusion standards

1. age<18 years old or>70 years old patient。

2. gestation or women breast-feeding their children。

3. there are the cardiovascular disease such as acute myocardial infarction, cardiogenic shock, advanced heart failure, severe arrhythmia, merge severe hypertension, severe pulmonary insufficiency, bronchial asthma, hepatic and renal function injure, disease of hematopoietic system or psychotic。

4. the person that has hyperthyroidism crisis。

5. thyroid enlarges markedly and adjacent organs is produced pressure symptom person。

6. various thyroiditiss。

7. use other medications, particularly trial drug is had the medicine (as taken Folium Digitalis Purpureae, potassium salt, turning class and antiarrhythmic drug) of considerable influence, affects effectiveness and safety judgement person。

8. allergic constitution or easy in multi-medicament allergy sufferers。

1.6 cases are rejected and come off standard

1. all cases not meeting inclusive criteria and be strayed into should be rejected；

2. irregular observation measurement or data not umbra sound observation judgement person should reject。

3. in observing, patient bolter voluntarily should be regarded as coming off；

4. occur that adverse events should not continue observer and be considered as coming off in observing。

1.7 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, be decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of。

1.8 treatment fore-and-aft observing indexs

(1) thyroid function: FT3, FT4, TSH。

(2) ambulatory electrocardiogram: record average heart rate, abnormal heart rhythm (such as atrial fibrillation, Fang Zao etc.) number of times and conclusion。

(3) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, it is designated as 0,1,2,3 point respectively。

(4) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit etc.。

1.9 arrhythmia curative effect determinate standards

1. effective: cardiopalmus transference cure, heart rate recovered to normal range, and dynamic electrocardiogram illustrates normally or abnormal heart rhythm number of times relatively treats front minimizing more than 74%。

2. effective: cardiopalmus symptom major part disappears, and heart rate drops to less than 100 beats/min, and ambulatory electrocardiogram does not reach arm's length standard, abnormal heart rhythm attack times reduces more than 50% before relatively treating。

3. invalid: cardiopalmus symptom, heart rate and ambulatory electrocardiogram treatment front and back are unchanged or increase the weight of。

1.10 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002。

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%。

Computing formula: nimodipine method: integration x100% before (before treatment integration after integration-treatment)/treatment。

1.11 statistical method

SPSS14.0 version statistical software is adopted to be analyzed。Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment。

2. result

The 2.1 treatment forward backward averaging rhythms of the heart compare

After treatment, average heart rate is (73.84 ± 4.76) beat/min, relatively (368.82 ± 13.35) beat/min before treatment, hence it is evident that reduce, and difference has statistical significance (t=6.263, P < 0.05)。

Thyroid function before and after 2.2 treatments

After treatment, FT3, FT4 substantially reduce before all relatively treating, and TSH relatively treats front significantly raised, and difference has statistical significance (P < 0.05), in Table 1。

Before and after table 1 treatment, thyroid function compares

Time	Number of cases	FT3	FT4	TSH
					Before treatment	140	21.54±2.54	30.52±3.42	0.17±0.09
After treatment	140	2.84±0.44	5.26±1.37	3.72±0.41
					T value	--	5.564	5.916	6.273 5 -->
P value	--	0.025	0.019	0.014

2.3 arrhythmia curative effects

140 example patient's arrhythmia curative effects: cure 127 examples, effective 10 examples, effective 3 examples, invalid 0 example。Curative effect: cure rate 90.7%, total obvious effective rate 97.9%, total effective rate is 100%。

TCM syndrome integration and TCM syndrome curative effect before and after 2.4 treatments

TCM syndrome total mark (5.98 ± 1.52) point after treatment, relatively (32.21 ± 4.42) before treatment are clearly aobvious reduces, and difference has statistical significance (t=6.273, P < 0.05)；140 example patient's TCM syndrome curative effects: cure 130 examples, effective 9 examples, effective 1 example, invalid 0 example。Curative effect: cure rate 92.9%, total obvious effective rate 99.3%, total effective rate is 100%。

2.5 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit are without significant change, and drug safety is better。

Claims (3)

1. treat blood stasis type hyperthyroidism and merge a Chinese medicine composition for atrial fibrillation, be made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 4-8 part, Cortex Ulmi virgatae 4-8 part, Flos Caryophylli Flos jasmini 4-8 part, FLOS MUME 4-8 part, Herba lathyri davidii 4-8 part, Manglietia yuyuanensis fruit 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, redwood 4-8 part, Radix Rhynchoglossi Obliqui 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part。

2. treatment blood stasis type hyperthyroidism according to claim 1 merges the Chinese medicine composition of atrial fibrillation, it is characterised in that be made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 5-7 part, Cortex Ulmi virgatae 5-7 part, Flos Caryophylli Flos jasmini 5-7 part, FLOS MUME 5-7 part, Herba lathyri davidii 5-7 part, Manglietia yuyuanensis fruit 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, redwood 5-7 part, Radix Rhynchoglossi Obliqui 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part。

3. treatment blood stasis type hyperthyroidism according to claim 3 merges the Chinese medicine composition of atrial fibrillation, it is characterised in that be made up of the Chinese medicine of following weight portion:

Huechys sanguinea De Geer. 6 parts, Cortex Ulmi virgatae 6 parts, Flos Caryophylli Flos jasmini 6 parts, FLOS MUME 6 parts, Herba lathyri davidii 6 parts, Manglietia yuyuanensis fruit 6 parts, Pericarpium Sterculiae nobilis 6 parts, redwood 6 parts, Radix Rhynchoglossi Obliqui 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。