CN105687752A - Traditional Chinese medicine composition for treating heart-spleen deficiency type hyperthyreosis with atrial flutter - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating heart-spleen deficiency type hyperthyreosis with atrial flutter. The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of grifola frondosa, 4-8 parts of parish's ironwee, 4-8 parts of roots of triplostegia glandulifera Wall., 4-8 parts of semen thujae koraiensis, 4-8 parts of rhizomes of medical angiopteris, 4-8 parts of root-bark of ficus fulva reinw.ex Bl, 4-8 parts of satyrium roots, 4-8 parts of herb of nutgrass galingale, 4-8 parts of fiveleaf akebia fruit, 4-8 parts of herb of goodyera schlechtendaliana Reichb.f., 4-8 parts of fruit of celastrus flagellaris Rupr., 4-8 parts of herb of ziziphora clinopodioides Lam. and 4-8 parts of licorice roots. All the medicine materials are cooperatively used to jointly achieve the effects of strengthening the spleen, nourishing the heart, invigorating qi and blood, softening hardness to dissipate stagnation, calming the mind and soothing the nerves. The average heart rate can be lowered, the thyroid function level can be recovered, no influence is generated on the safety indexes, and the safety is good.

Description

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter。

Background technology

Hyperthyroidism can cause different ARR generation, arrhythmia is sometimes even for the medical symptom and sign occurred the earliest, most of patients is gone to a doctor with arrhythmia for onset symptoms, and patient is tachy-arrhythmia, and wherein atrial flutter and atrial fibrillation are modal types。Easily there is mistaken diagnosis, fail to pinpoint a disease in diagnosis in hyperthyroid arrhythmia, delay treatment, and primary disease treatment cycle is longer, and symptom is not easily alleviated, and easily recur, such as malpractice or delay treatment, cardiac structure and physiological function can be caused great infringement, even produce irreversibility heart change。

The pathogeny that current doctor trained in Western medicine merges atrial flutter for hyperthyroidism still imperfectly understands, and treatment aspect there is no effective Therapeutic Method。

Type of deficiency of both the heart and spleen is the type that hyperthyroidism merges that atrial flutter is common, has not yet to see the medicine being exclusively used in such hyperthyroidism merging atrial flutter。

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter。

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, is made up of the Chinese medicine of following weight portion:

Grifola frondosa 4-8 part, disperse 4-8 part, Radix Triplostegiae Glanduliferae 4-8 part, thuja koraiensis nakai core 4-8 part, Rhizoma Angiopteridis Officinalis 4-8 part, Ficus fulva Reinw. 4-8 part, the blue 4-8 part of the southern regions of the Yunnan Province bird foot, dried tuber 4-8 part, Fructus Akebiae 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part greatly。

Preferably, above-mentioned treatment type of deficiency of both the heart and spleen hyperthyroidism merges the Chinese medicine composition of atrial flutter, is made up of the Chinese medicine of following weight portion:

Grifola frondosa 5-7 part, disperse 5-7 part, Radix Triplostegiae Glanduliferae 5-7 part, thuja koraiensis nakai core 5-7 part, Rhizoma Angiopteridis Officinalis 5-7 part, Ficus fulva Reinw. 5-7 part, the blue 5-7 part of the southern regions of the Yunnan Province bird foot, dried tuber 5-7 part, Fructus Akebiae 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part greatly。

It is furthermore preferred that above-mentioned treatment type of deficiency of both the heart and spleen hyperthyroidism merges the Chinese medicine composition of atrial flutter, it is made up of the Chinese medicine of following weight portion:

Grifola frondosa 6 parts, greatly disperse 6 parts, Radix Triplostegiae Glanduliferae 6 parts, thuja koraiensis nakai core 6 parts, Rhizoma Angiopteridis Officinalis 6 parts, Ficus fulva Reinw. 6 parts, blue 6 parts of the southern regions of the Yunnan Province bird foot, dried tuber 6 parts, Fructus Akebiae 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged。

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose。

The indication of Chinese medicine of the present invention: be used for treating type of deficiency of both the heart and spleen hyperthyroidism and merge atrial flutter。

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period。

In the Chinese medicine composition of the present invention,

Grifola frondosa is the sporophore of On Polyporaceae hen of the woods Polyporusfrondosus (Dicks.) Fr. [BoletusfrondosusDicks.]。Sweet in the mouth；Property is put down。Function replenishing QI to invigorate the spleen；Qi-restoratives righting。Main deficiency of the spleen causing weakness of QI；Fatigue and asthenia；Spiritlessness and sparing of words；Diet reduces；Abdominal distention after meal；The person that has above-mentioned symptom after tumor patient radiotherapy or chemotherapy。

Disperse greatly another name Semen Sojae Preparatum leaf, Caulis et folium clerodendri bungei Radix Polygalae, for the root of Burma, feverfew Yunnan Herba Vernonia esculenta VernoniaparishiiHook.F. [V.uolkameriifolia (Wall.) DC.Var.lanataS.YHu]。Sweet in the mouth；Bitter；Property is put down。Function expelling wind and clearing away heat；Nourish heart qi-restoratives。Main cold, fever；Nervous cardiopalmus；Rheumatic ostalgia；Hepatitis。

Radix Triplostegiae Glanduliferae another name all draws ginseng, all draws (" Traditional Chinese Medicine in Sichuan will "), Radix Satyrii nepalensis, Radix Triplostegiae Grandiflorae, Radix Raphani ginseng, soil Herba Patriniae (" Kunming conventional medical herbs among the people ")。Root for Dipsacaceae plant southwest capsule bud flower。Sweet in the mouth is pungent, warm in nature。Enter lung, spleen two warp。Function QI invigorating tonifying YANG, hemostasis of nourishing heart。Controlling sexual impotence, leucorrhea, rheumatic heart disease, asthenia chronic cough, knife injury is hemorrhage。

Thuja koraiensis nakai core another name Thuja koraiensis core, Semen Platycladi, for the kernel of Cupressaceae plant thuja koraiensis nakai ThujakoraiensisNakai。Sweet in the mouth；Pungent；Property is put down。Function tranquilizing by nourishing the heart；Loosening bowel to relieve constipation。Main palpitation and insomnia；Hyperhidrosis is passed out semen；Dryness of the intestine constipation。

Rhizoma Angiopteridis Officinalis another name Rhizoma Angiopteridis Officinalis lotus throne Herba pteridii latiusculi, for the rhizome with petiole base of Angiopteridaceae plant Rhizoma Angiopteridis Officinalis kwan-yin seat lotus Herba pteridii latiusculi AngiopterisofficinalisChing。Feeble QI, mildly bitter flavor, cool in nature。GUIXIN；Liver；Gallbladder meridian。Function tranquilizing by nourishing the heart；Clearing heat for detumescence；Cough-relieving。Main neurasthenia；Schizophrenia；Icterohepatitis；Mumps；Carbuncle；Venom；Pneumonia；Cough；Coronary heart disease。

Ficus fulva Reinw. another name the tiger palm, crow wind, amnesty mother-in-law tree, hair, derive from moraceae plants Ficus fulva Reinw. FicusfulvaReiuw., be used as medicine with root bark。Nature and flavor are sweet, flat。Function invigorating the spleen and benefiting QI, promoting blood circulation by removing wind。Curing mainly deficient qi and blood, uterine prolapse, proctoptosis, edema, rheumatic arthralgia, has loose bowels in loose stool。

The southern regions of the Yunnan Province bird foot blue another name Radix Satyrii nepalensis, Chicken Drumsticks, derive from the orchid family the southern regions of the Yunnan Province blue SatyriumhenryiSchlecht. of bird foot, be used as medicine with tuber。Sweet in the mouth, property is put down。Function strengthening waist and nourishing kidney, nourishing blood to tranquillize the mind。Cure mainly lumbago due to renal deficiency, chronic nephritis, face foot edema, heart disease, leucorrhea。

Dried tuber call Sha with, marquis, Sha, hair, later green grass or young crops, wild leek, overnight take out, trench is careless, little Rhizoma Sparganii, measle, contracting contracting grass, pass through grass, Herba Adianti, cake grass, hang horse palm fibre, soil Rhizoma et radix valerianae, Pilus Sus domestica green grass or young crops, Herba Caricis Phacotae。Stem and leaf for dried tuber tannin plant dried tuber CyperusrotundusL.。Bitter in the mouth；Pungent；Cool in nature。Return liver；Lung meridian。Function activating QI to alleviate the depression；Dispelling wind for relieving itching；Wide born of the same parents' profit expectorant。Master is uncomfortable in chest does not relax；Rubella pruritus；Carbuncle is with toxic swelling。Thorn bud fruits of Celastrus orbiculatus Thunb is the fruit of Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr.。Bitter in the mouth；Pungent；Property is put down。Function mind tranquilizing and the heart calming；Activating collaterals to relieve pain；Removing toxic substances and promoting subsidence of swelling。Main palpitation and insomnia；Bones and muscles pain；Waist-leg is numb；Toothache；Sore swollen toxin。

Fructus Akebiae another name poultry, take son, small wooden raft, cover son, August short, bristly hair or beard, Caulis Akebiae son, son of helping get over a shock, Fructus Akebiae, Fructus Akebiae, August be fried, August fruit, one hundred days melon, lead rattan melon, cold rice packet, draw really, open country perfume friendship, YANGKAIKOU, cured melon。Mature fruit for plants of Lardizabalaceae Caulis Akebiae Akebiaquinata (Thunb.) Decne, threeleaf akebia A.trifoliata (Thunb.) Koidz.var.australis (Dies) .Rehd.。Hiding micro-hardship, property is put down。Return liver, stomach, bladder warp。Return liver；Stomach warp。Function dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis。Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor。

Herba goodyearae repentis another name silver wire basin, nine layers of lid, Radix primulae sinodenticulatae, little general, lobule is blue or green, Folium Cannabis is blue or green, Trimeresurus stejnegeri, Agkistrodon medicine, point leaf mountain butterfly, the little green grass or young crops of Folium Bambusae, lung hornwart, Rhizoma pinelliae cordatae, Oxyria sinensis Hemsl., silver earring, for the big Herba goodyearae repentis GoodyeraschlechtendalianaReichb.f. of orchid, little Herba goodyearae repentis goodyerarepens (L.) R.Br. [SatyriumrepensL.], the herb of big piebaldism orchid .Goodyerabifora (Lindl.) Hook.f. [GeorchisbifloraLindl.] or floss tikka aspidistra GoodyeravelutinaMaxim.。Sweet in the mouth；Pungent；Property is put down。Function nourishing the lung to arrest cough；Tonify Qi of the kidney；Promoting flow of QI and blood；Subduing swelling and detoxicating。Main pulmonary tuberculosis cough；Tracheitis；Dizzy weak；Neurasthenia；Sexual impotence；Traumatic injury；Arthralgia；Laryngopharynx swelling and pain；Acute mastitis；Furuncle；Scrofula；Venom。

Thorn bud fruits of Celastrus orbiculatus Thunb is the fruit of Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr.。Bitter in the mouth；Pungent；Property is put down。Function mind tranquilizing and the heart calming；Activating collaterals to relieve pain；Removing toxic substances and promoting subsidence of swelling。Main palpitation and insomnia；Bones and muscles pain；Waist-leg is numb；Toothache；Sore swollen toxin。

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali, for the Herb of labiate lip Rhizoma et radix valerianae ZiziphoraclinopodioidesLam.。Acrid in the mouth；Cool in nature。Function mind tranquilizing and the heart calming；Diuretic heat clearing away。Main cardiopalmus；Insomnia；Edema；Cold, fever；Conjunctival congestion and swelling pain；Sore swollen toxin。

Radix Glycyrrhizae is sweet, flat。GUIXIN, lung, spleen, stomach warp。Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。

Although the traditional Chinese medical science does not have hyperthyroidism to merge the name of disease of atrial flutter, but the feature such as become thin according to its throat enlargement, cardiopalmus, excited, aversion to heat hyperhidrosis nervous, irritable, dry mouth and throat, polyphagia, the ownership traditional Chinese medical science " goiter ", " cardiopalmus " category。The present inventor sums up years of work experience, it is believed that primary disease is how relevant with deficiency of both the heart and spleen。Therefore with invigorating spleen and nourishing heart, benefiting vital QI and blood, hard masses softening and resolving, mind tranquilizing and the heart calming ruling by law is treated type of deficiency of both the heart and spleen hyperthyroidism and is merged atrial flutter。

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: disperse greatly, Radix Triplostegiae Glanduliferae merit is with the qi-restoratives that nourishes heart。

Ministerial drug: Grifola frondosa, Ficus fulva Reinw. merit are with replenishing QI to invigorate the spleen；

Adjuvant drug: thuja koraiensis nakai core, Rhizoma Angiopteridis Officinalis merit are with tranquilizing by nourishing the heart；The southern regions of the Yunnan Province blue merit of bird foot is with nourishing blood to tranquillize the mind；Dried tuber merit is with activating QI to alleviate the depression；Fructus Akebiae, Herba goodyearae repentis merit are with hard masses softening and resolving；Thorn bud fruits of Celastrus orbiculatus Thunb, lip Rhizoma et radix valerianae merit are with mind tranquilizing and the heart calming。

Make medicine: Radix Glycyrrhizae merit is with easing up the urgency with moist and sweet drugs, coordinating the actions of various ingredients in a prescription。

We's compatibility is reasonable, and all medicines share plays invigorating spleen and nourishing heart altogether, benefiting vital QI and blood, hard masses softening and resolving, the effect of mind tranquilizing and the heart calming method。Type of deficiency of both the heart and spleen hyperthyroidism of linking closely merges the pathogenesis of atrial flutter。Improving clinical symptoms, reduce average heart rate, correct the rhythm of the heart, recover thyroid function level, and safety indexes is without impact, safety is good。

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention。

Embodiment 1

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, each crude drug weight proportion is as follows:

Grifola frondosa 6g, disperse 6g, Radix Triplostegiae Glanduliferae 6g, thuja koraiensis nakai core 6g, Rhizoma Angiopteridis Officinalis 6g, Ficus fulva Reinw. 6g, the blue 6g of the southern regions of the Yunnan Province bird foot, dried tuber 6g, Fructus Akebiae 6g, Herba goodyearae repentis 6g, thorn bud fruits of Celastrus orbiculatus Thunb 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g greatly。

Embodiment 2

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, each crude drug weight proportion is as follows:

Grifola frondosa 5g, disperse 7g, Radix Triplostegiae Glanduliferae 5g, thuja koraiensis nakai core 7g, Rhizoma Angiopteridis Officinalis 5g, Ficus fulva Reinw. 7g, the blue 5g of the southern regions of the Yunnan Province bird foot, dried tuber 7g, Fructus Akebiae 5g, Herba goodyearae repentis 7g, thorn bud fruits of Celastrus orbiculatus Thunb 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g greatly。

Embodiment 3

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, each crude drug weight proportion is as follows:

Grifola frondosa 7g, disperse 5g, Radix Triplostegiae Glanduliferae 7g, thuja koraiensis nakai core 5g, Rhizoma Angiopteridis Officinalis 7g, Ficus fulva Reinw. 5g, the blue 7g of the southern regions of the Yunnan Province bird foot, dried tuber 5g, Fructus Akebiae 7g, Herba goodyearae repentis 5g, thorn bud fruits of Celastrus orbiculatus Thunb 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g greatly。

Embodiment 4

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, each crude drug weight proportion is as follows:

Grifola frondosa 4g, disperse 8g, Radix Triplostegiae Glanduliferae 4g, thuja koraiensis nakai core 8g, Rhizoma Angiopteridis Officinalis 4g, Ficus fulva Reinw. 8g, the blue 4g of the southern regions of the Yunnan Province bird foot, dried tuber 8g, Fructus Akebiae 4g, Herba goodyearae repentis 8g, thorn bud fruits of Celastrus orbiculatus Thunb 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g greatly。

Embodiment 5

A kind of Chinese medicine composition treating type of deficiency of both the heart and spleen hyperthyroidism merging atrial flutter, each crude drug weight proportion is as follows:

Grifola frondosa 8g, disperse 4g, Radix Triplostegiae Glanduliferae 8g, thuja koraiensis nakai core 4g, Rhizoma Angiopteridis Officinalis 8g, Ficus fulva Reinw. 4g, the blue 8g of the southern regions of the Yunnan Province bird foot, dried tuber 4g, Fructus Akebiae 8g, Herba goodyearae repentis 4g, thorn bud fruits of Celastrus orbiculatus Thunb 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g greatly。

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose hyperthyroidism merge atrial flutter (type of deficiency of both the heart and spleen) patient 130 example, wherein male 40 examples, female 90 example, the mean age (45.78 ± 12.43) year。

1.2 Western medicine diagnose standards

Formulate according to " practical internal medicine " and " inner-sphere reorganization energy "。

1. hyperthyroidism: FT3>7pg/mL, FT4>21pg/mL, TSH<0.35MIU/L。

2. atrial flutter: hole P ripple disappears, instead form, amplitude, spacing identical in pin tooth shape or wavy F ripple, frequency 250～350 beats/min, QRS form is identical with hole, and common Atrioventricular Conduction ratio is that 2:1 is alternatively 3:1,4:1。

1.3 differential diagnosis in tcm standards

With reference to the diagnostic criteria of " syndrome of deficiency of both heart and spleen " in " new Chinese medicine guideline of clinical investigations ": primary symptom: cardiopalmus is timid, kind doubting of thinking much, dizziness and fatigue。Secondary disease: throat lump, insomnia, forgetful, poor appetite, lustreless complexion。Picture of the tongue pulse condition: pale tongue, white and thin fur, thready pulse。All possess primary symptom and more than two persons of secondary disease, and can make a definite diagnosis with reference to tongue arteries and veins。

1.4 inclusive criterias

1. Informed Consent Form is signed。

2. age 18～70 years old。

3. Chinese and western medicine diagnostic criteria is met。

4. before patient enters group, Zhou Wei takes anxiety depression medicine or antipsychotics。

1.5 exclusion standards

1. age<18 years old or>70 years old patient。

2. gestation or women breast-feeding their children。

3. there are the cardiovascular disease such as acute myocardial infarction, cardiogenic shock, advanced heart failure, severe arrhythmia, merge severe hypertension, severe pulmonary insufficiency, bronchial asthma, hepatic and renal function injure, disease of hematopoietic system or psychotic。

4. the person that has hyperthyroidism crisis。

5. thyroid enlarges markedly and adjacent organs is produced pressure symptom person。

6. various thyroiditiss。

7. use other medications, particularly trial drug is had the medicine (as taken Folium Digitalis Purpureae, potassium salt, turning class and antiarrhythmic drug) of considerable influence, affects effectiveness and safety judgement person。

8. allergic constitution or easy in multi-medicament allergy sufferers。

1.6 cases are rejected and come off standard

1. all cases not meeting inclusive criteria and be strayed into should be rejected；

2. irregular observation measurement or data not umbra sound observation judgement person should reject。

3. in observing, patient bolter voluntarily should be regarded as coming off；

4. occur that adverse events should not continue observer and be considered as coming off in observing。

1.7 Therapeutic Method

Adopt the extract oral treatment of the embodiment of the present invention 1, be decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of。

1.8 treatment fore-and-aft observing indexs

(1) thyroid function: FT3, FT4, TSH。

(2) ambulatory electrocardiogram: record average heart rate, abnormal heart rhythm (such as atrial fibrillation, Fang Zao etc.) number of times and conclusion。

(3) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, it is designated as 0,1,2,3 point respectively。

(4) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit etc.。

1.9 arrhythmia curative effect determinate standards

1. effective: cardiopalmus transference cure, heart rate recovered to normal range, and dynamic electrocardiogram illustrates normally or abnormal heart rhythm number of times relatively treats front minimizing more than 74%。

2. effective: cardiopalmus symptom major part disappears, and heart rate drops to less than 100 beats/min, and ambulatory electrocardiogram does not reach arm's length standard, abnormal heart rhythm attack times reduces more than 50% before relatively treating。

3. invalid: cardiopalmus symptom, heart rate and ambulatory electrocardiogram treatment front and back are unchanged or increase the weight of。

1.10 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002。

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%。

Computing formula: nimodipine method: integration x100% before (before treatment integration after integration-treatment)/treatment。

1.11 statistical method

SPSS14.0 version statistical software is adopted to be analyzed。Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment。

2. result

The 2.1 treatment forward backward averaging rhythms of the heart compare

After treatment, average heart rate is (73.42 ± 4.56) beat/min, relatively (137.52 ± 12.43) beat/min before treatment, hence it is evident that reduce, and difference has statistical significance (t=5.813, P < 0.05)。

Thyroid function before and after 2.2 treatments

After treatment, FT3, FT4 substantially reduce before all relatively treating, and TSH relatively treats front significantly raised, and difference has statistical significance (P < 0.05), in Table 1。

Before and after table 1 treatment, thyroid function compares

Time	Number of cases	FT3	FT4	TSH
					Before treatment	130	18.34±2.75	29.35±3.72	0.22±0.15
After treatment	130	3.09±0.52	4.22±1.31	2.59±0.42
					T value	--	4.847	5.438	5.998
P value	--	0.024	0.021	0.019

2.3 arrhythmia curative effects

130 example patient's arrhythmia curative effects: cure 121 examples, effective 7 examples, effective 2 examples, invalid 0 example。Curative effect: cure rate 93.1%, total obvious effective rate 98.5%, total effective rate is 100%。

TCM syndrome integration and TCM syndrome curative effect before and after 2.4 treatments

TCM syndrome total mark (5.52 ± 1.41) point after treatment, relatively (33.14 ± 4.65) before treatment are clearly aobvious reduces, and difference has statistical significance (t=5.726, P < 0.05)；130 example patient's TCM syndrome curative effects: cure 124 examples, effective 5 examples, effective 1 example, invalid 0 example。Curative effect: cure rate 95.4%, total obvious effective rate 99.2%, total effective rate is 100%。

2.5 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit are without significant change, and drug safety is better。

Claims (3)

1. treat type of deficiency of both the heart and spleen hyperthyroidism and merge a Chinese medicine composition for atrial flutter, be made up of the Chinese medicine of following weight portion:

Grifola frondosa 4-8 part, disperse 4-8 part, Radix Triplostegiae Glanduliferae 4-8 part, thuja koraiensis nakai core 4-8 part, Rhizoma Angiopteridis Officinalis 4-8 part, Ficus fulva Reinw. 4-8 part, the blue 4-8 part of the southern regions of the Yunnan Province bird foot, dried tuber 4-8 part, Fructus Akebiae 4-8 part, Herba goodyearae repentis 4-8 part, thorn bud fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part greatly。

2. treatment type of deficiency of both the heart and spleen hyperthyroidism according to claim 1 merges the Chinese medicine composition of atrial flutter, it is characterised in that be made up of the Chinese medicine of following weight portion:

Grifola frondosa 5-7 part, disperse 5-7 part, Radix Triplostegiae Glanduliferae 5-7 part, thuja koraiensis nakai core 5-7 part, Rhizoma Angiopteridis Officinalis 5-7 part, Ficus fulva Reinw. 5-7 part, the blue 5-7 part of the southern regions of the Yunnan Province bird foot, dried tuber 5-7 part, Fructus Akebiae 5-7 part, Herba goodyearae repentis 5-7 part, thorn bud fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part greatly。

3. treatment type of deficiency of both the heart and spleen hyperthyroidism according to claim 3 merges the Chinese medicine composition of atrial flutter, it is characterised in that be made up of the Chinese medicine of following weight portion:

Grifola frondosa 6 parts, greatly disperse 6 parts, Radix Triplostegiae Glanduliferae 6 parts, thuja koraiensis nakai core 6 parts, Rhizoma Angiopteridis Officinalis 6 parts, Ficus fulva Reinw. 6 parts, blue 6 parts of the southern regions of the Yunnan Province bird foot, dried tuber 6 parts, Fructus Akebiae 6 parts, Herba goodyearae repentis 6 parts, thorn bud fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae。