CN105616994A

CN105616994A - Traditional Chinese medicine composition for treating liver yin deficiency type cardiovascular neurosis

Info

Publication number: CN105616994A
Application number: CN201610081776.XA
Authority: CN
Inventors: 不公告发明人
Original assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Current assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Priority date: 2016-02-06
Filing date: 2016-02-06
Publication date: 2016-06-01

Abstract

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine composition for treating liver yin deficiency type cardiovascular neurosis. The traditional Chinese medicine composition comprises, by weight, 4-8 parts of caragana microphylla, 4-8 parts of Balanophora polyandra Griff., 4-8 parts of flos edgeworthlae, 4-8 parts of Bulbopyllum psychoon Reichb.f. [B.levinei Schltr.], 4-8 parts of radix cynanchi auriculati, 4-8 parts of Crepis phoenix Dunn, 4-8 parts of delonix regia, 4-8 parts of Phtheirospermum tenuisectum Bur. et Franch., 4-8 parts of Rhizoma Angiopleris Officinalis, 4-8 parts of Satyrium henryi Schlecht., 4-8 parts of nutgrass flatsedge, 4-8 parts of Ziziphora clinopodioides Lam and 4-8 parts of radix glycyrrhizae. The traditional Chinese medicine composition has the advantages that the medicinal materials are combined to achieve synergic effects of nourishing yin essence and tonifying the liver and kidney, and the traditional Chinese medicine composition can effectively lower the Hamilton anxiety scale integral and Hamilton depression scale integral of patients with the liver yin deficiency type cardiovascular neurosis and improve the anxiety and depression symptoms of the patients with the liver yin deficiency type cardiovascular neurosis.

Description

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type heart neurosis

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type heart neurosis.

Background technology

Heart neurosis is a class due to the dysfunction of central nervous system, affects vegetative nerve function and the clinical syndrome being main manifestations with systema cariovasculare functional imbalance that causes. Along with social pressure constantly increases, China heart neurosis patient morbidity raises year by year, and heart neurosis is easily obscured with the disease such as angina pectoris, viral myocarditis again mutually simultaneously, easily causes the probably frightened of people. Owing to lacking specific diagnostic criteria, organic heart disease need to be got rid of, easily cause spirit and financial burden to patient. The pathogenesis of heart neurosis there is no and is expressly recited, and modern medicine thinks that spirit is relevant with its pathogenesis with psychological factor. Current doctor trained in Western medicine still imperfectly understands for the pathogeny of heart neurosis, and treatment aspect there is no effective Therapeutic Method.

Deficiency and exhaustion of liver-YIN type is the type that heart neurosis is common, has not yet to see the medicine being exclusively used in such heart neurosis.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type heart neurosis.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type heart neurosis, is made up of the Chinese medicine of following weight portion:

Herba Caraganae intermediae 4-8 part, exceedingly high wax candle 4-8 part, flowers of Edgeworthia chrysantha Lindl 4-8 part, only leaf rock pearl 4-8 part, Radix cynanchi wilfordii 4-8 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 4-8 part, Ramulus et Folium Delonicis regiae 4-8 part, Phtheirospermum tenuisectum Bur.et Franch. 4-8 part, Rhizoma Angiopteridis Officinalis 4-8 part, the southern regions of the Yunnan Province bird foot blue 4-8 part, dried tuber 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment deficiency and exhaustion of liver-YIN type heart neurosis, it is made up of the Chinese medicine of following weight portion:

Herba Caraganae intermediae 5-7 part, exceedingly high wax candle 5-7 part, flowers of Edgeworthia chrysantha Lindl 5-7 part, only leaf rock pearl 5-7 part, Radix cynanchi wilfordii 5-7 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5-7 part, Ramulus et Folium Delonicis regiae 5-7 part, Phtheirospermum tenuisectum Bur.et Franch. 5-7 part, Rhizoma Angiopteridis Officinalis 5-7 part, the southern regions of the Yunnan Province bird foot blue 5-7 part, dried tuber 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part.

It is furthermore preferred that the Chinese medicine composition of above-mentioned treatment deficiency and exhaustion of liver-YIN type heart neurosis, it is made up of the Chinese medicine of following weight portion:

Herba Caraganae intermediae 6 parts, 6 parts of exceedingly high wax candle, flowers of Edgeworthia chrysantha Lindl 6 parts, 6 parts of only leaf rock pearl, Radix cynanchi wilfordii 6 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6 parts, Ramulus et Folium Delonicis regiae 6 parts, Phtheirospermum tenuisectum Bur.et Franch. 6 parts, Rhizoma Angiopteridis Officinalis 6 parts, blue 6 parts of the southern regions of the Yunnan Province bird foot, dried tuber 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged.

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for treating deficiency and exhaustion of liver-YIN type heart neurosis.

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period.

In the Chinese medicine composition of the present invention,

Radix Caraganae intermediae is the root of leguminous plant Caragana intermedia CaraganaintermediaKuangetH.C.Fu. Taste is micro-pungent; Warm in nature. GUIXIN; Liver Channel. Function supplementing QI and nourishing YIN. Main dizziness, cardiopalmus, shortness of breath and fatigue, hypertension.

Exceedingly high wax candle another name timber fungus Herba Cistanches, native, for the herb of Balanophoraceae plant Herba Balanophorae polyandrae BalanophorapolyandraGriff. �� Poly-plethiapolyandra (Griff.) vanTiegh. ��. Bitter in the mouth; Micro-puckery; Property is put down. Function heat-clearing and toxic substances removing; Nourishing YIN and benefiting blood; Hemostasis. Main gonorrhea; Prunus mume (sieb.) sieb.et zucc. poison; Blood deficiency; Hemorrhage.

Flowers of Edgeworthia chrysantha Lindl another name gold gum bag, knotting flower, dream Flos Farfarae, happiness flower, for the alabastrum of Isolated From Thymelaeaceae Species Edgeworthia chrysantha Lindl. EdgeworthiachrysanthaLindl.. Property is put down, lightly seasoned. Function yin nourishing is calmed the nerves, and improving eyesight is dispelled and hidden from view. For optic atrohic blindness, cataracta, many tear, nocturnal emission, empty pouring, aphonia.

Only leaf rock pearl another name Herba Bulbophylli radiati, Moghania fluminalis(C. B. Clarke) Li, Herba sagittariae pygmaeae are blue, for the herb of orchid tooth lobe Bulbophyllum BulbopyllumpsychoonReichb.f. [B.levineiSchltr.]. Sweet in the mouth; Light; Cold in nature. Function nourishing YIN and clearing away heat; Removing toxic substances and promoting subsidence of swelling. Main yin asthenia generating intrinsic heat; Calentura is thirsty; Lung-heat cough with asthma; Laryngopharynx swelling and pain; Stomatitis; Rheumatic arthralgia; Traumatic injury; Acute mastitis; Furuncle swells.

Radix cynanchi wilfordii another name Radix Cynanchi Auriculati [Jilin], white grandmother, fresh kidney beans Carnis Mactrae, cross mountain waft, without fine strain of millet rattan, derive from trailing plants section Cynanchum plant Radix cynanchi wilfordii Cynanchumwilfordii(Maxim.) Hemsl., be used as medicine with tuber. Sweet in the mouth, micro-hardship, property is put down. Function liver and kidney tonifying, bone and muscle strengthening. For neurasthenia, sexual impotence, seminal emission, lumbago and skelalgia.

Crepis crocea Babc.(C.turczaninowii C.A.Mey.) another name Radix Crepidis elongatae, nandina ginseng, Radix Crepidis Ligneae, horse hair ginseng, for the root of outstanding zhang of deep CrepisphoenixDunn of feverfew Folium Bambusae ten thousand. Bitter in the mouth; Sweet; Warm in nature. Function liver and kidney tonifying; Invigorating spleen to remove dampness. Master has a dizzy spell; Soreness of the waist and knees; Edema; Leukorrhagia infantile malnutrition; Hypogalactia.

Ramulus et Folium Delonicis regiae is the bark of leguminous plant Ramulus et Folium Delonicis regiae Delonixregia (Bojea) Rofin.. Sweet in the mouth; Light; Cold in nature. Return Liver Channel. Function suppressing the hyperactive liver and subsiding YANG. Main liver-heat type hypertension, dizziness, vexed not peaceful.

Phtheirospermum tenuisectum Bur.et Franch. another name Folium Pini Rhizoma seu Herba Elatostematis stewardii, Folium Pini Artemisia, Herba pteridis vittatae, derive from Scrophulariaceae Phtheirospermum plant Phtheirospermum tenuisectum Bur.et Franch. PhtheirospermumtenuisectumBur.etFranch. with root, all herbal medicine. Function heat-clearing and toxic substances removing, tranquilizing by nourishing the heart, pain relieving. For having a weak heart, cardiopalmus, cough, sputum mixed with blood, laryngopharynx swelling and pain, fracture; Serpentis, lyssodexis are controlled in external.

Rhizoma Angiopteridis Officinalis another name Rhizoma Angiopteridis Officinalis lotus throne Herba pteridii latiusculi, for the rhizome with petiole base of Angiopteridaceae plant Rhizoma Angiopteridis Officinalis kwan-yin seat lotus Herba pteridii latiusculi AngiopterisofficinalisChing. Feeble QI, mildly bitter flavor, cool in nature. GUIXIN; Liver; Gallbladder meridian. Function tranquilizing by nourishing the heart; Clearing heat for detumescence; Cough-relieving. Main neurasthenia; Schizophrenia; Icterohepatitis; Mumps; Carbuncle; Venom; Pneumonia; Cough; Coronary heart disease.

The southern regions of the Yunnan Province bird foot blue another name Radix Satyrii nepalensis, Chicken Drumsticks, derive from the orchid family the southern regions of the Yunnan Province blue SatyriumhenryiSchlecht. of bird foot, be used as medicine with tuber. Sweet in the mouth, property is put down. Function strengthening waist and nourishing kidney, nourishing blood to tranquillize the mind. Cure mainly lumbago due to renal deficiency, chronic nephritis, face foot edema, heart disease, leucorrhea.

Dried tuber call Sha with, marquis, Sha, hair, later green grass or young crops, wild leek, overnight take out, trench is careless, little Rhizoma Sparganii, measle, contracting contracting grass, pass through grass, Herba Adianti, cake grass, hang horse palm fibre, soil Rhizoma et radix valerianae, Pilus Sus domestica green grass or young crops, Herba Caricis Phacotae. Stem and leaf for dried tuber tannin plant dried tuber CyperusrotundusL.. Bitter in the mouth; Pungent; Cool in nature. Return liver; Lung meridian. Function activating QI to alleviate the depression; Dispelling wind for relieving itching; Wide born of the same parents' profit expectorant. Master is uncomfortable in chest does not relax; Rubella pruritus; Carbuncle is with toxic swelling.

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali, for the Herb of labiate lip Rhizoma et radix valerianae ZiziphoraclinopodioidesLam.. Acrid in the mouth; Cool in nature. Function mind tranquilizing and the heart calming; Diuretic heat clearing away. Main cardiopalmus; Insomnia; Edema; Cold, fever; Conjunctival congestion and swelling pain; Sore swollen toxin.

Radix Glycyrrhizae is sweet, flat. GUIXIN, lung, spleen, stomach warp. Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.

Although the traditional Chinese medical science does not have the name of disease of heart neurosis, but can be undertaken diagnosing and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs by " cardiopalmus " " chest pain " " being insomnia " etc. according to clinical characters such as its cardiopalmus, precordialgia, uncomfortable in chest, insomnias. Primary disease is many to be caused a disease by emotional factors, patient's irritable emotion, be panic-stricken, chest full vexed, assist distending pain or irritability happiness to cry, or pharynx has the symptoms such as foreign body sense of obstruction, the traditional Chinese medical science can belong to " melancholia " category. The present inventor sums up years of work experience, it is believed that heart neurosis is how relevant with deficiency and exhaustion of liver-YIN. Detesting Nervous and Mental Factors such as hating, resentfulness is angry, liver all can be made to lose bar and reach, functional activity of QI being not smooth, so that depression of liver-QI forms the stagnation of QI, this is the pathogenesis that melancholia is main. If the stagnation of QI is fire-transformation with the passing of time, then there is the pathological changes of flaming up of liver-fire, and form fire stagnation. Stagnated fire consumption impairment of YIN blood, then may result in deficiecny of liver-YIN. Therefore with nourishing essence, deficiency and exhaustion of liver-YIN type heart neurosis is treated in liver and kidney tonifying ruling by law.

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: Herba Caraganae intermediae, exceedingly high wax candle merit are with nourishing YIN and benefiting blood.

Ministerial drug: Radix cynanchi wilfordii, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) merit are with liver and kidney tonifying.

Adjuvant drug: Ramulus et Folium Delonicis regiae merit is with suppressing the hyperactive liver and subsiding YANG; Flowers of Edgeworthia chrysantha Lindl merit is calmed the nerves with yin nourishing; Only leaf rock pearl merit is with nourishing YIN and clearing away heat; Phtheirospermum tenuisectum Bur.et Franch., Rhizoma Angiopteridis Officinalis merit are with tranquilizing by nourishing the heart; The southern regions of the Yunnan Province blue merit of bird foot is with nourishing blood to tranquillize the mind; Dried tuber merit is with activating QI to alleviate the depression; Lip Rhizoma et radix valerianae merit is with mind tranquilizing and the heart calming.

Make medicine: Radix Glycyrrhizae merit is with easing up the urgency with moist and sweet drugs, coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays nourishing essence altogether, the effect of liver and kidney tonifying. Link closely the pathogenesis of heart neurosis (deficiency and exhaustion of liver-YIN card). Effectively reducing deficiency and exhaustion of liver-YIN type heart neurosis patient's TCM symptom score, improve heart neurosis patient clinical symptom, TCM syndrome is evident in efficacy. Deficiency and exhaustion of liver-YIN type heart neurosis patient's Hamilton anxiety scale integration and depression scale integration be can effectively reduce simultaneously, heart neurosis patient anxiety and depressive symptom improved. And safety indexes is without impact, and safety is good.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine composition treating deficiency and exhaustion of liver-YIN type heart neurosis, each crude drug weight proportion is as follows:

Herba Caraganae intermediae 6g, exceedingly high wax candle 6g, flowers of Edgeworthia chrysantha Lindl 6g, only leaf rock pearl 6g, Radix cynanchi wilfordii 6g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6g, Ramulus et Folium Delonicis regiae 6g, Phtheirospermum tenuisectum Bur.et Franch. 6g, Rhizoma Angiopteridis Officinalis 6g, the southern regions of the Yunnan Province bird foot blue 6g, dried tuber 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Herba Caraganae intermediae 7g, exceedingly high wax candle 5g, flowers of Edgeworthia chrysantha Lindl 7g, only leaf rock pearl 5g, Radix cynanchi wilfordii 7g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 7g, Ramulus et Folium Delonicis regiae 5g, Phtheirospermum tenuisectum Bur.et Franch. 7g, Rhizoma Angiopteridis Officinalis 5g, the southern regions of the Yunnan Province bird foot blue 7g, dried tuber 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g.

Embodiment 3

Herba Caraganae intermediae 5g, exceedingly high wax candle 7g, flowers of Edgeworthia chrysantha Lindl 5g, only leaf rock pearl 7g, Radix cynanchi wilfordii 5g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5g, Ramulus et Folium Delonicis regiae 7g, Phtheirospermum tenuisectum Bur.et Franch. 5g, Rhizoma Angiopteridis Officinalis 7g, the southern regions of the Yunnan Province bird foot blue 5g, dried tuber 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g.

Embodiment 4

Herba Caraganae intermediae 8g, exceedingly high wax candle 4g, flowers of Edgeworthia chrysantha Lindl 8g, only leaf rock pearl 4g, Radix cynanchi wilfordii 8g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 8g, Ramulus et Folium Delonicis regiae 4g, Phtheirospermum tenuisectum Bur.et Franch. 8g, Rhizoma Angiopteridis Officinalis 4g, the southern regions of the Yunnan Province bird foot blue 8g, dried tuber 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g.

Embodiment 5

Herba Caraganae intermediae 4g, exceedingly high wax candle 8g, flowers of Edgeworthia chrysantha Lindl 4g, only leaf rock pearl 8g, Radix cynanchi wilfordii 4g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 4g, Ramulus et Folium Delonicis regiae 8g, Phtheirospermum tenuisectum Bur.et Franch. 4g, Rhizoma Angiopteridis Officinalis 8g, the southern regions of the Yunnan Province bird foot blue 4g, dried tuber 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g.

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose deficiency and exhaustion of liver-YIN type heart neurosis patient 130 example, wherein male 77 examples, female 53 example, year mean age (46.31 �� 12.87).

1.2 Western medicine diagnose standards

According in " practical internal medicine ", the diagnostic criteria of heart neurosis is formulated.

1. cardiovascular dysfunction symptom: cardiopalmus, breathe hard, precordialgia etc.;

2. general neurosis performance: dizziness, insomnia, anxiety, anxiety, hyperhidrosis etc.

3. detailed whole body and cardiovascular system aspect inspection confirm to there is no organic heart disease deteriorated case evidence.

1.3 differential diagnosis in tcm standards

With reference to " deficiency and exhaustion of liver-YIN type " diagnostic criteria in " new Chinese medicine guideline of clinical investigations ": primary symptom: irritable emotion, being irritable and getting angry easily, dizziness, tinnitus. Secondary disease: order does photophobia, fuzzy viewing, or headache and swollen, flushing conjunctival congestion. Picture of the tongue pulse condition: dry tongue is red, stringy and thready pulse or number. CM syndrome differentiation criterion: primary symptom >=3; Or primary symptom 2+secondary disease >=3.

1.4 inclusive criterias

1. Informed Consent Form is signed.

2. age 18��70 years old.

3. Chinese and western medicine diagnostic criteria is met.

4. before patient enters group, Zhou Wei takes anxiety depression medicine or antipsychotics.

1.5 exclusion standards

1. merging the organic heart diseasies such as coronary heart disease, myocarditis, heart film disease, echocardiography shows that heart has the exception of 26S Proteasome Structure and Function.

2. incretion metabolism disease, such as hyperthyroidism, pheochromocytoma etc.; And the ST-T section that other reason causes changes, as the reaction of low potassium, Folium Digitalis Purpureae or other medicines and " juvenile T wave pattern " change.

3. severe heart and lung diseases, hepatic renal dysfunction and severe arrhythmia (as paroxysmal room speed, atrial fibrillation, supraventricular tachycardia, sick hole, room are flutterred) patient it are associated with.

4. spiritedness disease or mental sickness family history.

5. Hamilton anxiety scale 14 (HAMA) > 29 points.

6. Hamilton depressive scale 24 (HAMD) > 35 points.

7. it is pregnent well and sprays breast phase women.

8. compliance is poor, it is impossible to take medicine on time, it is difficult to complete experimenter.

1.6 cases are rejected and come off standard

1. all cases not meeting inclusive criteria and be strayed into should be rejected;

2. irregular observation measurement or data not umbra sound observation judgement person should reject.

3. in observing, patient bolter voluntarily should be regarded as coming off;

4. occur that adverse events should not continue observer and be considered as coming off in observing.

1.7 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, prescription is as follows: Herba Caraganae intermediae 6g, exceedingly high wax candle 6g, flowers of Edgeworthia chrysantha Lindl 6g, only leaf rock pearl 6g, Radix cynanchi wilfordii 6g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 6g, Phtheirospermum tenuisectum Bur.et Franch. 6g, Rhizoma Angiopteridis Officinalis 6g, the southern regions of the Yunnan Province bird foot blue 6g, dried tuber 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g, it is decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of.

1.8 treatment fore-and-aft observing indexs

(1) Hamilton anxiety scale (HAMA) and Hamilton depressive scale (HAMD).

(2) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, it is designated as 0,1,2,3 point respectively.

(3) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit, electrocardiogram etc.

1.9 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002.

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: nimodipine method: integration �� 100% before (before treatment integration after integration-treatment)/treatment.

1.10 statistical method

SPSS14.0 version statistical software is adopted to be analyzed. Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment.

2. result

Before and after 2.1 treatments, lab index compares

Substantially reducing before Hamilton anxiety scale (HAMA) and Hamilton depressive scale (HAMD) scoring all relatively treatment after treatment, difference has statistical significance (P < 0.05), in Table 1.

Before and after table 1 treatment, anxiety and depression scores compare

Time	Number of cases	HAMA(divides)	HAMD(divides)
				Before treatment	130	23.23��4.89	24.45��5.11
After treatment	130	5.14��1.54	5.12��1.16
				T value	--	4.953	5.977
P value	--	0.023	0.019

TCM syndrome integration and TCM syndrome curative effect before and after 2.2 treatments

TCM syndrome total mark (5.24 �� 1.25) point after treatment, relatively (24.39 �� 5.14) before treatment are clearly aobvious reduces, and difference has statistical significance (t=5.634, P < 0.05); 130 example patient's TCM syndrome curative effects: cure 117 examples, effective 8 examples, effective 5 examples, invalid 0 example. Curative effect: cure rate 90.0%, total obvious effective rate 96.2%, total effective rate is 100%.

2.3 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit and electrocardiogram are without significant change, and drug safety is better.

Claims

1. treat a Chinese medicine composition for deficiency and exhaustion of liver-YIN type heart neurosis, be made up of the Chinese medicine of following weight portion:

2. the Chinese medicine composition for the treatment of deficiency and exhaustion of liver-YIN type heart neurosis according to claim 1, it is characterised in that be made up of the Chinese medicine of following weight portion:

3. the Chinese medicine composition for the treatment of deficiency and exhaustion of liver-YIN type heart neurosis according to claim 3, it is characterised in that be made up of the Chinese medicine of following weight portion: