CN105726959A

CN105726959A - Traditional Chinese medicine composition for treating heart-yin insufficiency type cardiac neurosis

Info

Publication number: CN105726959A
Application number: CN201610081775.5A
Authority: CN
Inventors: 李宁
Original assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Current assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Priority date: 2016-02-06
Filing date: 2016-02-06
Publication date: 2016-07-06

Abstract

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine composition for treating heart-yin insufficiency type cardiac neurosis.The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of caragana microphylla lam, 4-8 parts of balanophora polyandra griff, 4-8 parts of edgeworthia chrysantha flowers, 4-8 parts of bulbophyllum psychoon reichb.f., 4-8 parts of Parish's ironweed, 4-8 parts of common triplostegia roots, 4-8 parts of finelydivided phtheirospermum roots, 4-8 parts of medical angiopteris rhizome, 4-8 parts of satyrium henryi schlecht, 4-8 parts of nutgrass flatsedge, 4-8 parts of ziziphora clinopodioides lam and 4-8 parts of liquorice roots.The medicinal materials achieve the effects of nourishing yin and blood, tonifying the heart and tranquilizing mind.The traditional Chinese medicine composition can effectively reduce the Hamilton manifest anxiety scale integral and the depression scale integral of patients suffering from heart-yin insufficiency type cardiac neurosis, and improve the anxiety and depression symptoms of the patients suffering from cardiac neurosis.

Description

A kind of Chinese medicine composition treating the heart-yin deficiency heart neurosis

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating the heart-yin deficiency heart neurosis Thing.

Background technology

Heart neurosis is a class due to the dysfunction of central nervous system, affect vegetative nerve function and cause with Systema cariovasculare functional imbalance is the clinical syndrome of main performance.Along with social pressure constantly increases, China's heart neurosis Patient morbidity raises year by year, and heart neurosis is easily obscured with the disease such as angina pectoris, viral myocarditis again mutually simultaneously, Easily cause the most frightened of people.Owing to lacking specific diagnostic criteria, organic heart disease need to be got rid of, easily cause spirit to patient And financial burden.The pathogenesis of heart neurosis there is no and is expressly recited, modern medicine think spirit with psychological factor with its Pathogenesis is shaped with pass.Doctor trained in Western medicine is not fully understood for the pathogeny of heart neurosis at present, and treatment aspect there is no effectively to be controlled Treatment method.

The heart-yin deficiency is the type that heart neurosis is common, has had not yet to see and has been exclusively used in such cardiac nerve The medicine of disease.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that Yi Zhongzhi Treat the Chinese medicine composition of the heart-yin deficiency heart neurosis.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating the heart-yin deficiency heart neurosis, is made up of the Chinese medicine of following weight portion:

Herba Caraganae intermediae 4-8 part, exceedingly high wax candle 4-8 part, flowers of Edgeworthia chrysantha Lindl 4-8 part, only leaf rock pearl 4-8 part, greatly dissipate 4-8 part, Radix Triplostegiae Glanduliferae 4-8 part, Phtheirospermum tenuisectum Bur.et Franch. 4-8 part, Rhizoma Angiopteridis Officinalis 4-8 part, the southern regions of the Yunnan Province bird foot blue 4-8 part, dried tuber 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment the heart-yin deficiency heart neurosis, by the Chinese medicine of following weight portion Composition:

Herba Caraganae intermediae 5-7 part, exceedingly high wax candle 5-7 part, flowers of Edgeworthia chrysantha Lindl 5-7 part, only leaf rock pearl 5-7 part, greatly dissipate 5-7 part, Radix Triplostegiae Glanduliferae 5-7 part, Phtheirospermum tenuisectum Bur.et Franch. 5-7 part, Rhizoma Angiopteridis Officinalis 5-7 part, the southern regions of the Yunnan Province bird foot blue 5-7 part, dried tuber 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part.

It is furthermore preferred that the Chinese medicine composition of above-mentioned treatment the heart-yin deficiency heart neurosis, by following weight portion Medicine forms:

Herba Caraganae intermediae 6 parts, 6 parts of exceedingly high wax candle, flowers of Edgeworthia chrysantha Lindl 6 parts, 6 parts of only leaf rock pearl, greatly dissipate 6 parts, Radix Triplostegiae Glanduliferae 6 parts, Phtheirospermum tenuisectum Bur.et Franch. 6 parts, fixed The heart dissipates 6 parts, the southern regions of the Yunnan Province bird 6 parts of orchid, dried tuber 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts of Radix Glycyrrhizae enough.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, obesity Or the patient of slight of stature, the proportioning of the amount of composition can be adjusted accordingly, be increased or decreased less than 100%, drug effect is basically unchanged.

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for treating the heart-yin deficiency heart neurosis.

The taboo item of Chinese medicine of the present invention: period is taken medicine in treatment, and fasting is greasy, raw and cold, the smelling of fish or mutton, irritant and be difficult to disappear The food changed.

In the Chinese medicine composition of the present invention,

Radix Caraganae intermediae is the root of leguminous plant Caragana intermedia Caragana intermedia Kuang et H.C.Fu.Taste is micro-pungent； Warm in nature.GUIXIN；Liver Channel.Function supplementing QI and nourishing YIN.Main dizziness, cardiopalmus, shortness of breath and fatigue, hypertension.

Exceedingly high wax candle another name timber fungus Herba Cistanches, native, for Balanophoraceae plant Herba Balanophorae polyandrae Balanophora polyandra Griff. the herb of ［ Poly-plethia polyandra (Griff.) vanTiegh. ］.Bitter in the mouth；Micro-puckery；Property flat.Function is clear Thermal detoxification；Nourishing YIN and benefiting blood；Hemostasis.Main gonorrhea；Syphilis；Blood deficiency；Hemorrhage.

Dissipate greatly another name Semen Sojae Preparatum leaf, Caulis et folium clerodendri bungei Radix Polygalae, for Burma, feverfew Yunnan Herba Vernonia esculenta Vernonia parishii Hook. the root of F. [V. uolkameriifolia (Wall.) DC. Var. lanata S.Y Hu].Sweet in the mouth；Bitter；Property Flat.Function expelling wind and clearing away heat；Nourish heart qi-restoratives.Main cold, fever；Nervous cardiopalmus；Rheumatic ostalgia；Hepatitis.

Radix Triplostegiae Glanduliferae another name all draws ginseng, all draws (" Traditional Chinese Medicine in Sichuan will "), and Radix Satyrii nepalensis, Radix Triplostegiae Grandiflorae, Radix Raphani ginseng, (" Kunming is among the people for native Herba Patriniae Conventional medical herbs ").Root for Dipsacaceae plant southwest capsule bud flower.Sweet in the mouth is pungent, warm in nature.Enter lung, spleen two warp.Function QI invigorating tonifying YANG, Nourish heart hemostasis.Controlling sexual impotence, leucorrhea, rheumatic heart disease, asthenia chronic cough, knife injury is hemorrhage.

Flowers of Edgeworthia chrysantha Lindl another name gold gum bag, knotting flower, dream Flos Farfarae, happiness flower, for Isolated From Thymelaeaceae Species Edgeworthia chrysantha Lindl. Edgeworthia The alabastrum of chrysantha Lindl..Property flat, lightly seasoned.Function yin nourishing is calmed the nerves, and improving eyesight is dispelled and hidden from view.For optic atrohic blindness, cataracta, many Tear, nocturnal emission, empty pouring, aphonia.

Solely leaf rock pearl another name Herba Bulbophylli radiati, Moghania fluminalis(C. B. Clarke) Li, Herba sagittariae pygmaeae orchid, for orchid tooth lobe Bulbophyllum Bulbopyllum psychoon Reichb.f. the herb of [B.levinei Schltr.].Sweet in the mouth；Light；Cold in nature.Function nourishing YIN and clearing away heat；Removing toxic substances and promoting subsidence of swelling.The main deficiency of YIN Interior-heat；Calentura is thirsty；Lung-heat cough with asthma；Laryngopharynx swelling and pain；Stomatitis；Rheumatic arthralgia；Traumatic injury；Acute mastitis；Furuncle swells.

Phtheirospermum tenuisectum Bur.et Franch. another name Folium Pini Rhizoma seu Herba Elatostematis stewardii, Folium Pini Artemisia, Herba pteridis vittatae, derive from Scrophulariaceae Phtheirospermum plant Phtheirospermum tenuisectum Bur.et Franch. Phtheirospermum tenuisectum Bur. et Franch. is with root, all herbal medicine.Function heat-clearing and toxic substances removing, nourish heart peace God, pain relieving.For having a weak heart, cardiopalmus, cough, sputum mixed with blood, laryngopharynx swelling and pain, fracture；Serpentis, lyssodexis are controlled in external.

Rhizoma Angiopteridis Officinalis another name Rhizoma Angiopteridis Officinalis lotus throne Herba pteridii latiusculi, for Angiopteridaceae plant Rhizoma Angiopteridis Officinalis kwan-yin seat lotus Herba pteridii latiusculi Angiopteris The rhizome of the band petiole base of officinalis Ching.Feeble QI, mildly bitter flavor, cool in nature.GUIXIN；Liver；Gallbladder meridian.Function nourishes heart peace God；Clearing heat for detumescence；Cough-relieving.Main neurasthenia；Schizophrenia；Icterohepatitis；Mumps；Carbuncle；Venom；Pneumonia；Cough； Coronary heart disease.

The southern regions of the Yunnan Province bird foot blue another name Radix Satyrii nepalensis, Chicken Drumsticks, derive from the orchid family the southern regions of the Yunnan Province blue Satyrium henryi of bird foot Schlecht., it is used as medicine with tuber.Sweet in the mouth, property is put down.Function strengthening waist and nourishing kidney, nourishing blood to tranquillize the mind.Cure mainly lumbago due to renal deficiency, chronic nephritis, Face foot edema, heart disease, leucorrhea.

Dried tuber call Sha with, marquis, Sha, hair, later green grass or young crops, wild leek, overnight take out, trench is careless, little Rhizoma Sparganii, measle, Contracting contracting grass, pass through grass, Herba Adianti, cake grass, hang that horse Rhizoma et radix valerianae brown, native, Pilus Sus domestica be blue or green, Herba Caricis Phacotae.For dried tuber tannin plant dried tuber The stem and leaf of Cyperus rotundus L..Bitter in the mouth；Pungent；Cool in nature.Return liver；Lung meridian.Function activating QI to alleviate the depression；Dispelling wind for relieving itching；Wide born of the same parents' profit Expectorant.Master is uncomfortable in chest does not relaxes；Rubella pruritus；Carbuncle is with toxic swelling.

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali, for labiate lip Rhizoma et radix valerianae Ziziphora clinopodioides Lam. Herb.Acrid in the mouth；Cool in nature.Function mind tranquilizing and the heart calming；Diuretic heat clearing away.Main cardiopalmus；Insomnia；Edema；Cold, fever；Conjunctival congestion swells Bitterly；Sore swollen toxin.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, adjust With all medicines.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, delay Solve drug toxicity, strong.

Although the traditional Chinese medical science does not has the name of disease of heart neurosis, but according to clinics such as its cardiopalmus, precordialgia, uncomfortable in chest, insomnias Feature can be carried out diagnosing and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs by " cardiopalmus " " chest pain " " being insomnia " etc..Primary disease is many to be caused a disease by emotional factors, patient's feelings Thread is peaceful, be panic-stricken, chest is the most vexed, assist distending pain or irritability happiness to cry, or has the symptoms such as foreign body sense of obstruction in pharynx, and the traditional Chinese medical science can belong to " melancholia " category.The present inventor sums up years of work experience, it is believed that heart neurosis is how relevant with the heart-yin virtual loss.Owing to being willing to not Then, psychentonia, the Nervous and Mental Factors such as family does not gets along well, and meets with an misfortune, worried grief, damage heart spleen, make the heart become homeless and support and occur one Wide array of pathologies.If consuming sad the moon so that the heart-yin virtual loss, hyperactivity of heart-fire, the most vexed, low grade fever, flushed face, thready and rapid pulse.Therefore to grow The moon nourishes blood, and the heart-yin deficiency heart neurosis is treated in heart tonifying and tranquilizing ruling by law.

The Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: Herba Caraganae intermediae, exceedingly high wax candle merit are with nourishing YIN and benefiting blood.

Ministerial drug: dissipate greatly, Radix Triplostegiae Glanduliferae merit is with the qi-restoratives that nourishes heart；

Adjuvant drug: flowers of Edgeworthia chrysantha Lindl merit is calmed the nerves with yin nourishing；Solely leaf rock pearl merit is with nourishing YIN and clearing away heat；Phtheirospermum tenuisectum Bur.et Franch., Rhizoma Angiopteridis Officinalis merit are with tranquilizing by nourishing the heart； The southern regions of the Yunnan Province blue merit of bird foot is with nourishing blood to tranquillize the mind；Dried tuber merit is with activating QI to alleviate the depression；Lip Rhizoma et radix valerianae merit is with mind tranquilizing and the heart calming.

Make medicine: Radix Glycyrrhizae merit is with easing up the urgency with moist and sweet drugs, coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays nourishing YIN and benefiting blood altogether, the effect of heart tonifying and tranquilizing.The heart-yin that links closely deficiency cardiac nerve The pathogenesis of disease.Can effectively reduce the heart-yin deficiency heart neurosis patient's TCM symptom score, improve heart neurosis patient and face Bed symptom, TCM syndrome is evident in efficacy.Can effectively reduce the heart-yin deficiency heart neurosis patient's HAMA amount simultaneously Table integration and depression scale integration, improve heart neurosis patient anxiety and depressive symptom.And safety indexes is without impact, peace Full property is good.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine composition treating the heart-yin deficiency heart neurosis, each crude drug weight proportion is as follows:

Herba Caraganae intermediae 6g, exceedingly high wax candle 6g, flowers of Edgeworthia chrysantha Lindl 6g, only leaf rock pearl 6g, greatly dissipate 6g, Radix Triplostegiae Glanduliferae 6g, Phtheirospermum tenuisectum Bur.et Franch. 6g, Rhizoma Angiopteridis Officinalis 6g, The southern regions of the Yunnan Province bird foot blue 6g, dried tuber 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Herba Caraganae intermediae 7g, exceedingly high wax candle 5g, flowers of Edgeworthia chrysantha Lindl 7g, only leaf rock pearl 5g, greatly dissipate 7g, Radix Triplostegiae Glanduliferae 5g, Phtheirospermum tenuisectum Bur.et Franch. 7g, Rhizoma Angiopteridis Officinalis 5g, The southern regions of the Yunnan Province bird foot blue 7g, dried tuber 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g.

Embodiment 3

Herba Caraganae intermediae 5g, exceedingly high wax candle 7g, flowers of Edgeworthia chrysantha Lindl 5g, only leaf rock pearl 7g, greatly dissipate 5g, Radix Triplostegiae Glanduliferae 7g, Phtheirospermum tenuisectum Bur.et Franch. 5g, Rhizoma Angiopteridis Officinalis 7g, The southern regions of the Yunnan Province bird foot blue 5g, dried tuber 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g.

Embodiment 4

Herba Caraganae intermediae 8g, exceedingly high wax candle 4g, flowers of Edgeworthia chrysantha Lindl 8g, only leaf rock pearl 4g, greatly dissipate 8g, Radix Triplostegiae Glanduliferae 4g, Phtheirospermum tenuisectum Bur.et Franch. 8g, Rhizoma Angiopteridis Officinalis 4g, The southern regions of the Yunnan Province bird foot blue 8g, dried tuber 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g.

Embodiment 5

Herba Caraganae intermediae 4g, exceedingly high wax candle 8g, flowers of Edgeworthia chrysantha Lindl 4g, only leaf rock pearl 8g, greatly dissipate 4g, Radix Triplostegiae Glanduliferae 8g, Phtheirospermum tenuisectum Bur.et Franch. 4g, Rhizoma Angiopteridis Officinalis 8g, The southern regions of the Yunnan Province bird foot blue 4g, dried tuber 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g.

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose the heart-yin deficiency heart neurosis patient 120 example, the maleest 72 examples, female 48 example, the mean age (48.34 ± 12.76) year.

1.2 Western medicine diagnose standards

Formulate according to diagnostic criteria to heart neurosis in " practical internal medicine ".

1. cardiovascular dysfunction symptom: cardiopalmus, breathe hard, precordialgia etc.；

2. general neurosis performance: dizziness, insomnia, anxiety, anxiety, hyperhidrosis etc..

The most detailed whole body and cardiovascular system aspect inspection confirm to there is no organic heart disease deteriorated case evidence.

1.3 differential diagnosis in tcm standards

With reference to " the heart-yin deficiency " diagnostic criteria in " new Chinese medicine guideline of clinical investigations ": primary symptom: irritable emotion, cardiopalmus, Forgetful, insomnia, dreaminess.Secondary disease: dysphoria with feverish sensation in the chest palms and soles, night sweat, pharyngoxerosis.Picture of the tongue pulse condition: red tongue with a little fluid, thready and rapid pulse.CM syndrome differentiation criterion: Primary symptom >=3；Or primary symptom 2+secondary disease >=3.

1.4 inclusive criteria

1. Informed Consent Form is signed.

2. the age 18～70 years old.

3. Chinese and western medicine diagnostic criteria is met.

4. before patient enters group, Zhou Wei takes anxiety depression medicine or antipsychotics.

1.5 exclusion standard

1. merge the organic heart diseasies such as coronary heart disease, myocarditis, heart film be sick, echocardiography show heart have structure and The exception of function.

2. incretion metabolism disease, such as hyperthyroidism, pheochromocytoma etc.；And the ST-T that other reason causes Section changes, as the reaction of low potassium, Folium Digitalis Purpureae or other medicines and " juvenile T wave pattern " change.

3. be associated with severe heart and lung diseases, hepatic renal dysfunction, and severe arrhythmia (as paroxysmal room speed, atrial fibrillation, Supraventricular tachycardia, sick hole, room are flutterred) patient.

4. spiritedness disease or mental sickness family history.

5. Hamilton anxiety scale 14 (HAMA) > 29 points.

6. Hamilton depressive scale 24 (HAMD) > 35 points.

It is pregnent the best and sprays breast phase women.

8. compliance is poor, it is impossible to take medicine on time, it is difficult to complete experimenter.

1.6 cases are rejected and come off standard

The most all cases not meeting inclusive criteria and be strayed into should be rejected；

The most irregular observation is measured or data not umbra rings observation judgement person and should reject.

3. in observing, patient bolter voluntarily should be regarded as coming off；

4. occur that adverse events should not continue observer and be considered as coming off in observing.

1.7 Therapeutic Method

Using the Chinese medicine composition oral medication of the embodiment of the present invention 1, prescription is as follows: Herba Caraganae intermediae 6g, exceedingly high wax candle 6g, flowers of Edgeworthia chrysantha Lindl 6g, only leaf rock pearl 6g, greatly dissipate 6g, Radix Triplostegiae Glanduliferae 6g, Phtheirospermum tenuisectum Bur.et Franch. 6g, Rhizoma Angiopteridis Officinalis 6g, the blue 6g of the southern regions of the Yunnan Province bird foot, dried tuber 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g, is decocted in water for oral dose, day potion, sub-service sooner or later, is a course for the treatment of with 7d.

1.8 treatment fore-and-aft observing indexs

(1) Hamilton anxiety scale (HAMA) and Hamilton depressive scale (HAMD).

(2) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, weight, point It is not designated as 0,1,2,3 point.

(3) safety indexes: mensuration hematuria routine forward and backward to patient treatment, liver function, kidney merit, electrocardiogram etc..

1.9 TCM syndrome therapeutic evaluatioies

Evaluation criteria is with reference to " the new Chinese medicine clinical research medication guide principle " of promulgation in 2002.

1. recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

The most effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

The most effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

The most invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.

Computing formula: nimodipine method: integration × 100% before (integration after integration-treatment before treatment)/treatment.

1.10 statistical method

SPSS14.0 version statistical software is used to be analyzed.Measurement data represents with mean plus-minus standard deviation, compares before and after treatment Using t inspection, enumeration data represents with percentage rate, compares employing X 2 test before and after treatment, represents that difference has with P < 0.05 Statistical significance.

2. result

Before and after 2.1 treatments, lab index compares

Substantially drop before Hamilton anxiety scale (HAMA) and Hamilton depressive scale (HAMD) scoring the most relatively treatment after treatment Low, difference has statistical significance (P < 0.05), is shown in Table 1.

Before and after table 1 treatment, anxiety and depression scores compare

Time	Number of cases	HAMA(divides)	HAMD(divides)
				Before treatment	120	22.65±4.32	24.93±5.35
After treatment	120	5.43±1.32	5.14±1.11
				T value	--	4.945	5.943
P value	--	0.024	0.020

TCM syndrome integration and TCM syndrome curative effect before and after 2.2 treatments

TCM syndrome total mark (5.22 ± 1.82) point after treatment, relatively (24.76 ± 5.43) before treatment are the most aobvious to be reduced, difference There is statistical significance (t=5.653, P < 0.05)；120 example patient's TCM syndrome curative effects: cure 108 examples, effective 8 examples, effective 4 Example, invalid 0 example.Curative effect: cure rate 90.0%, total obvious effective rate 96.7%, total effective rate is 100%.

2.3 safety analysis

Treatment Patients Before And After routine blood test, Liver and kidney merit and electrocardiogram are without significant change, and drug safety is preferable.

Claims

1. treat a Chinese medicine composition for the heart-yin deficiency heart neurosis, be made up of the Chinese medicine of following weight portion:

The Chinese medicine composition for the treatment of the heart-yin deficiency heart neurosis the most according to claim 1, it is characterised in that by with The Chinese medicine composition of lower weight portion:

The Chinese medicine composition for the treatment of the heart-yin deficiency heart neurosis the most according to claim 3, it is characterised in that by with The Chinese medicine composition of lower weight portion: