CN102988747A - Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof - Google Patents
Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and a preparation method of the aristida triseta electuary. The aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia is prepared from Digou roxburgh rose, chaenomeles speciosa, multiflora rose root, radix cudramiae, radix pseudostellariae, rubia tinctorum madder root and sargentgloryvine stem according a certain weight proportion. The aristida triseta electuary, disclosed by the invention, functions on improving digestion, activating blood and dissolving stasis, eliminating phlegm and removing dampness, regulating blood sugar level, reducing blood fat and reducing cholesterol, takes effect quickly and has good treatment effects as well as high cure rate when being used for treating hypertension, hyperglycemia and hyperlipidemia.
Description
Technical field
The present invention relates to a kind for the treatment of take medicine and the preparation method of obesity as the metabolism syndrome of basic hypertension, hyperglycemia, hyperlipidemia three-hypers, belong to the field of Chinese medicines.
Background technology
The metabolic syndromes such as hyperlipidemia, hypertension, hyperglycemia take obesity as the basis rise year by year in recent years, and long term can concurrent cardiovascular and cerebrovascular disease, the serious threat mankind's health and lives.Through a large amount of research and clinical confirmation, mankind aging and the various diseases such as fat three-hypers metabolism syndrome that comprise cancer mainly are caused by the peroxide injury of self except heredity.Human body toxic molecule-free radical (rubbish in the body) that moment produces in biochemical process is to remove external by antioxidant system endogenous enzymes in the body.There is 2-3% in oxygen-derived free radicals in the normal human, and surpassing is exactly anoxia, makes the interior biomembrane of body be subjected to radical damage, and lipid peroxide (CPO) raises.Human body is dynamic equilibrium, i.e. balance between the oxidative and anti-oxidative.If the activity decreased of the superoxide dismutase of antioxidant system (SOD), glutathion peroxidase (GSH-Px), catalase (CAT) or quantity reduce, will disequilibrium, oxygen-derived free radicals will increase accumulation, causes various diseases to occur and the acceleration aging.Obesity is because the rising of cylinder super-oxidation lipid makes fat metabolic disturbance, and the triglyceride accumulation increases the sign that causes.Meanwhile low-density lipoprotein cholesterol raises, and HDL-C reduces, and blood fat is raise.Increase because lipid peroxide generates, free radical increases, and has destroyed cellularity, makes endocrine function generation obstacle, causes carbohydrate metabolism disturbance, blood sugar increasing.The rising formation blood plasma of blood fat, blood glucose is sticking, thick, dense, and vascular endothelial cell is destructurized, and the cholesterol intravasation endothelial injury place of rising is attached, and makes vessel wall thickening, and lumen of vessels narrows down and makes hypertension.On this basis, blood fat, cholesterol continuation rising arteriosclerosis have formed.Because the accumulation of cholesterol has formed calculus, the increasing of calculus make blood flow by slowly to being obstructed, cerebrovascular is obstructed, the formation cerebral thrombosis, cardiovascular is obstructed, and coronary heart disease occurs.Cardiovascular and cerebrovascular vessel can form cerebral infarction or heart infarction if the calculus sheet increases obstruction.It is optional that the disease of present treatment three-hypers there is no desirable medicine, and the doctor trained in Western medicine medication can only be symptomatic treatment also, takes medicine all the life, can not effect a radical cure.
Summary of the invention
Therefore there is great demand in people to the Chinese medicine of effective treatment three-hypers, also do not find at present about relevant report of the present invention, the inventor is through a large amount of development test and the repeatedly checking by clinical trial, finally work out the Chinese medicine composition of better treatment three-hypers, thereby finished the present invention.
Purpose of the present invention just provides a kind for the treatment of take the Chinese medicine composition of obesity as the three-hypers metabolism syndrome on basis.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention is to select enlightening ditch Fructus Rosae Normalis, Fructus Chaenomelis, Seem Lablab Album, Radix rosae multiflorae, Radix Cudraniae, Folium Rosae Normalis, Fructus Citri Sarcodactylis, Radix Pseudostellariae, Fructus Tonnae Sinensis, Radix Rubiae, Fructus Carthami tinctorii, Semen Ziziphi Spinosae, Cortex Lycii, Herba Taxilli, Radix Puerariae, Tremella, Ramulus Mori, Radix Angelicae Pubescentis, Rhizoma Alismatis Herba Polygoni Avicularis, Rhizoma Polygonati Odorati, Fructus Lycii, Caulis Sargentodoxae makes up, with these drug regimens so that each medicine produces mutually synergism, thereby can treat the recurrence of three-hypers disease, wherein select principal agent enlightening ditch Fructus Rosae Normalis to be because the wild original single-lobe Fructus Rosae Normalis that enlightening ditch Fructus Rosae Normalis is the inventor to be used special technology to go through to take pains to foster in more than 20 year, this kind only China is exclusive, and wild resource is few.Introduced after the deputy director Lai Peihan engineer of Simian Mountain orest management institute identifies from the Sichuan Jiangjin County in 1987.Fructus Rosae Normalis contains 16 kinds of hydrogen base acid, superoxide dismutase (SOD), every hectogram fresh fruit contains 2400 milligrams of VC, claim VC, VP " king ", also contain abundant VE, VD, VK, carotene, thiamine (b1), riboflavin (b2), folic acid (b14), also contain valley head alcohol, stearic acid, linolenic acid, roxburic acid, protein, triterpenoid saponin, flavochrome, tannin, essence, calcium, magnesium, phosphorus, ferrum, zinc.Carry out the five indices check through biology department of Qinhua Univ., Beijing and St Foods Q Supervision ﹠ Testing Center to dried roxburgh rose fruit in November, 1997, " St Foods Q Supervision ﹠ Testing Center " survey report, the result confirms, the medicinal component of enlightening ditch Fructus Rosae Normalis has increased precious trace element-selenium newly, Radix Dauci Sativae content increases 2-3 doubly, the scientific research personnel that the inventor finds associate professor Song Yuanju to lead to Beijing Medical University again takes the anticancer laboratory data of Fructus Rosae Normalis in 1986 therefrom.Select Fructus Chaenomelis, claim again Fructus Chaenomelis to be because Fructus Chaenomelis is the Fructus Chaenomelis that Xuancheng Profile, anhui Province produces, practise the title Fructus Chaenomelis, its nature and flavor acid, temperature enters liver, spleen channel, and suppressing the hyperactive liver and easing the stomach is arranged, and the function of the Shujin that dries is controlled the convulsion of vomiting and diarrhoea, the arthralgia chiefly caused by damp pathogen edema.Select Seem Lablab Album to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, have spleen invigorating and in, the function of the removing dampness of relieving summer heat is controlled heat-damp in summer and is vomited and diarrhoea, insufficiency of the spleen vomiting, the lack of appetite chronic diarrhea, water retention is quenched one's thirst, leucorrhea with red and white discharge, infantile malnutrition.Selecting Radix rosae multiflorae, have another name called thorn Mi root, is that cold enters spleen, stomach warp, and clearing away heat-damp and promoting diuresis is arranged, and dispels the wind because its nature and flavor are pained, invigorate blood circulation, the function of detoxifcation is controlled lung abscess, quenches one's thirst dysentery, arthritis, paralysis, tell, be defeated in battle, have blood in stool, frequent micturition, the enuresis, menoxenia, traumatic injury, furuncle scabies.Selecting Radix Cudraniae, have another name called three-bristle cudrania thorn root, is that cold has expelling wind and removing dampness because of its property mildly bitter flavor, and the function of promoting blood circulation to restore menstrual flow can be treated traumatic injury, jaundice, stranguria with turbid discharge, impairment caused by overstrain hemoptysis, dispelling the wind and dampness pathogens arthralgia, skin infection scabies.Select Folium Rosae Normalis to be because it has the treatment scabies, carbuncle, the function of incised wound.In addition, the inventor is alone enlightening ditch Folium Rosae Normalis treatment diabetics repeatedly once, the reducing blood sugar and blood fat successful.Select Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot are that temperature enters liver, stomach warp, regulates the flow of vital energy because its nature and flavor are arduous sour, and the function of reducing phlegm is treated for stomachache, and the side of body is swollen, and vomiting is dysphagic, the phlegm retention cough with asthma, and can relieve the effect of alcohol.Selecting Radix Pseudostellariae is that tepor enters the heart, spleen, lung three warps, and the function of tonifying the lung, spleen invigorating is arranged, and controls the cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus order antiperspirant, spirit is tired.Select Fructus Tonnae Sinensis to be because its nature and flavor temperature is arduous, enter the liver lung meridian, dispel the wind, cold expelling, the function of pain relieving is controlled the wind and cold diseases caused by exogenous pathogenic factor, heart peratodynia.Selecting Radix Rubiae is because of its nature and flavor bitter cold, and the GUIXIN Liver Channel has the promoting the circulation of blood hemostasis, and the function of dredge the meridian passage is controlled the haematemesis hematuria, metrorrhagia, rheumatic arthralgia, jaundice, chronic tracheitis.Select Fructus Carthami tinctorii, the different name SEMEN CARTHAMI is because it has the function of promoting blood circulation and detoxication, energy cholesterol reducing, blood fat reducing, expansion and vessel softening, endocrine regulation.Select Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, enter the heart, spleen, liver, gallbladder meridian, nourishing the liver is arranged, mind calming is calmed the nerves, and the function of arresting sweating is controlled restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select Cortex Lycii to be because its nature and flavor are sweet, cold, enter lung, liver, kidney channel, heat clearing away is arranged, the function of removing heat from blood is controlled asthenia hectic fever night sweat, and the lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood is quenched one's thirst, hypertension, carbuncle, malignant boil.Select Herba Taxilli to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, invigorating the liver and kidney is arranged, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function is controlled soreness of waist and knee joint, and is hemiplegia a little less than the muscles and bones flaccidity, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Select Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, enter spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is only drunk, it is cold to cure the wound, and it is cold to cure the wound, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, and dysentery, skin eruption are not saturating, hypertension, angina pectoris, deafness.Selecting Tremella, have another name called Tremella, is because its nature and flavor are sweet flat, and YIN nourishing is arranged, lung moistening, and nourishing the stomach, the function of promoting the production of body fluid is controlled cough due to consumptive disease, sputum mixed with blood, deficiency-heat is thirsty.Select Ramulus Mori to be because its nature and flavor are bitter, flat, enter Liver Channel, wind-damp dispelling is arranged, sharp joint, the function of row aqueous vapor is controlled anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Select Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature enters kidney, urinary bladder channel, dispels the wind, and win and wet, cold expelling, the function of pain relieving is controlled anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil is controlled dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Choosing is because its nature and flavor are bitter with Herba Polygoni Avicularis, and is cold, enters urinary bladder channel, and diuresis is arranged, heat clearing away, and the function of parasite killing is controlled pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid are swollen, eczema.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, the stomach warp has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst is controlled the calentura sun and is hindered, cough, excessive thirst, deficient fever, rapid digestion of food are easily hungry, frequent micturition.Select Fructus Lycii to be because its nature and flavor are sweet, flat, nourishing kidney is arranged, lung moistening, tonifying liver, the function that makes eye bright is controlled hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tears of blurred vision, cough due to consumptive disease is quenched one's thirst, and loses clear.Select Caulis Sargentodoxae to be because its nature and flavor are bitter, flat, enter liver, large intestine two warps, the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the function of wind dispelling insecticide is controlled acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.
The first-selected enlightening ditch of the present invention Fructus Rosae Normalis, thorn Mi root, three-bristle cudrania thorn root form three thorn electuaries.Containing superoxide dismutase (SOD) in the enlightening ditch Fructus Rosae Normalis that wherein inventor cultivates is macromolecular compound, is one of main endogenous enzymes of human body antioxidant system, is the strong anti-oxidation active substance, and free radical scavenging activity is reached 99%; Trace element-selenium is one of definite needed by human nutrition of the United Nations's health organization, claimed " anticancer king " to consist of the glutathione peroxidase active center by the physician, selenium can strengthen the activity at this center, make its oxidation resistance stronger 500 times than vitamin E, effectively remove free radical, selenium is the antioxidation reinforcing agent, and the ability of obvious promotion cellular uptake sugar can be arranged, and has the identical effect of insulin of pancreatic secretion; Carotene anti-cancer successful can prevent Common Cold, can cough-relieving, and energy blood fat reducing, blood sugar lowering have antioxidation, protect the function of cardiovascular and cerebrovascular vessel and neurocyte, and a carotene molecule can transform 4 A molecules; Experiment showed, that vitamin A can make the secretory volume of thrombolytic brinase active factors increase by 3.7 times, scientific research also shows, uses vitamin A and the C of equivalent, and the secretory volume of active factors rises to 21 times, is up to 50 times; Vitamin C is antioxidant, can reduce blood cholesterol and capillary fragility, can obviously alleviate diabetic symptom; Vitamin E is the Natural antioxidant, and at the collaborative lower more effective removing free radical of A, C, Citrin can strengthen the adhesion strength between human body cell, can prevent angiorrbagia, and the protection blood vessel makes it to keep normal physiological function; Vitamin D can reduce capillary fragility, prevents microvascular bleeding, and the effect of cholesterol reducing is arranged; Rigid acid, linolenic acid scalable lipid metabolism wadding are disorderly kept the normal physiological function of cell membrane, and treatment and prevention of obesity are sick; But tannin blood fat reducing.The traditional Chinese medical science thinks that enlightening ditch Fructus Rosae Normalis has invigorating the stomach and promoting digestion, activating QI to eliminate phlegm, blood circulation promoting and blood stasis dispelling, inducing diuresis and reducing edema, strengthening by means of tonics, Xing Yang calms the nerves and the function of two-ways regulation.The catalase that Fructus Chaenomelis in the compatibility drug contains (Chinese herbal medicine color atlas, Fujian science tech publishing house, nineteen ninety, Foochow) be one of three kinds of endogenous enzymes of human body antioxidant system, other two kinds is above-mentioned superoxide dismutase and glutathion peroxidase.The collaborative oxidation resistance that strengthens human body antioxygen system of we's Fructus Chaenomelis has been corrected unbalance between the human body oxidative and anti-oxidative, makes human body keep the dynamic equilibrium of normal physiological.Seem Lablab Album in the side, Radix Pseudostellariae, Rhizoma Polygonati Odorati, Fructus Lycii help with boosting qi and nourishing yin, three-bristle cudrania thorn root, Radix rosae multiflorae, Radix Rubiae, Caulis Sargentodoxae etc. help with cool the blood dissipate blood stasis, promoting blood circulation to restore menstrual flow, Fructus Citri Sarcodactylis, Tonnae Sinensis fruit, Fructus Chaenomelis help with activating QI to eliminate phlegm, stomach function regulating removing dampness, SEMEN CARTHAMI energy cholesterol reducing, blood fat reducing, expansion and vessel softening, endocrine regulation, Folium Rosae Normalis, Tremella, the blood fat reducing of Rhizoma Alismatis energy, blood sugar lowering, Cortex Lycii blood sugar lowering, cholesterol reducing.Radix Puerariae blood sugar lowering, blood pressure lowering, in addition Herba Taxilli ， Herba Polygoni Avicularis, Radix Angelicae Pubescentis, the Semen Ziziphi Spinosae etc. of blood pressure lowering.The traditional Chinese medical science is thought human body take logical as mending, and human body reaches the neither life of five-way all kinds of diseases and ailments.We not only mend but also logical, logical stagnant, logical refuse, logical cardiovascular and cerebrovascular vessel, ventilation, logical convenient to both.We's medicine mutually collaborative, interact and each composition between curative effect after the effect, reached medicine (effectiveness) gas (cause of disease) and be harmonious, the drum responding perfectly to the drumsticks, human body is had wet just remove, have expectorant just to change, have what just broken, have void just to mend, have fertilizer just to subtract, nothing is fertile in anti-normal physiological state.
The selected principal agent enlightening of the present invention ditch Fructus Rosae Normalis, thorn Mi root, three-bristle cudrania thorn root are equipped with the accessory drugs combination and make three thorns and fall the three-hypers electuary.
The constituent content of medicine of the present invention also is that the inventor draws through a large amount of Test Summaries, and the consumption of each component has preferably curative effect in the following weight scope:
Enlightening ditch Fructus Rosae Normalis 15-25 gram Fructus Chaenomelis 8-12 gram Seem Lablab Album 8-12 gram
Radix rosae multiflorae 8-12 gram Radix Cudraniae 8-12 gram Folium Rosae Normalis 5-10 gram
Fructus Citri Sarcodactylis 5-10 gram Radix Pseudostellariae 8-12 gram Fructus Tonnae Sinensis 5-10 gram
Radix Rubiae 8-12 gram Fructus Carthami tinctorii 2-5 gram Semen Ziziphi Spinosae 8-12 gram
Cortex Lycii 8-12 gram Herba Taxilli 8-12 gram Radix Puerariae 8-12 gram
Tremella 5-10 gram Ramulus Mori 8-12 gram Radix Angelicae Pubescentis 2-5 gram
Rhizoma Alismatis 5-8 Ke pivot holds 8-12 gram Rhizoma Polygonati Odorati 8-12 gram
Fructus Lycii 5-10 gram Caulis Sargentodoxae 8-12 gram
Preferable amount is
Enlightening ditch Fructus Rosae Normalis 18 gram Fructus Chaenomelis 9 gram Seem Lablab Albums 9 grams
Radix rosae multiflorae 9 gram Radix Cudraniaes 9 gram Folium Rosae Normaliss 6 grams
Fructus Citri Sarcodactylis 6 gram Radix Pseudostellariaes 9 gram Fructus Tonnae Sinensis 6 grams
Radix Rubiae 6 gram Fructus Carthami tinctoriis 3 gram Semen Ziziphi Spinosaes 9 grams
Cortex Lycii 9 gram Herba Taxillis 9 gram Radix Puerariaes 9 grams
Tremella 6 gram Ramulus Moris 9 gram Radix Angelicae Pubescentiss 3 grams
Rhizoma Alismatis 6 Ke pivots hold 9 gram Rhizoma Polygonati Odorati, 9 grams
Fructus Lycii 6 gram Caulis Sargentodoxae 9 grams
Preparation method of the present invention is as follows
One, gets the raw materials ready
1, enlightening ditch Fructus Rosae Normalis: choose high-quality Fructus Rosae Normalis fresh fruit, clear water is cleaned, and section is dried;
2, Fructus Chaenomelis: choose high-quality Fructus Chaenomelis fresh fruit, clear water is cleaned, and section is dried;
3, Seem Lablab Album: choose clean impurity, put in the boiling water and slightly boil, heave, softly pull out for degree to planting skin, immerse in the cold water, slough skin, dry;
4, Radix rosae multiflorae: choose clean impurity, clean and dry;
5, Radix Cudraniae: clean, run through, oblique section dries;
6, Folium Rosae Normalis: choose clean impurity, dry;
7, Fructus Citri Sarcodactylis: choose decontamination, after the water spray profit, chopping is dried;
8, Radix Pseudostellariae: extract fibrous root, dry;
9, Fructus Tonnae Sinensis: gather autumn, dries;
10, Radix Rubiae: choose clean impurity, remove Lu Miao, clean, run through rear timely section, dry;
11, Fructus Carthami tinctorii: choose clean impurity, dry;
12, Semen Ziziphi Spinosae: former medicine is put into the bamboo square-bottomed bamboo basket, sinks in the clear water cylinder, and core is kept afloat, and shell is heavy water-bed, will sting core and pull out, dries;
13, Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting;
14, Herba Taxilli: former medicine washes, and runs through, and cutting is dried;
15, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;
16, Tremella: choose decontamination, dry or dry;
17, Ramulus Mori: choose decontamination, clean, be soaked in water, after running through, cutting is dried;
18, Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through rear section, drying;
19, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is dried;
20,, Herba Polygoni Avicularis: remove impurity and root, clean, moisten softly, cutting is dried;
21, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
22, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;
23, Caulis Sargentodoxae: be soaked in water, clean spare, run through, section is dried.
Two, preparation
1, for preventing losing of the active ingredient such as VC, get fresh fruit fast low temperature 50-60 ℃ oven dry within the shortest time of enlightening ditch Fructus Rosae Normalis and the Fructus Chaenomelis of above-mentioned weight, wear into fine powder with Fructus Carthami tinctorii;
2, Seem Lablab Album, Radix rosae multiflorae, Radix Cudraniae, Folium Rosae Normalis, Fructus Citri Sarcodactylis, Radix Pseudostellariae, Fructus Tonnae Sinensis, Radix Rubiae, Semen Ziziphi Spinosae, Cortex Lycii, Herba Taxilli, Radix Puerariae, Tremella, Ramulus Mori, Radix Angelicae Pubescentis, Rhizoma Alismatis, Herba Polygoni Avicularis, Rhizoma Polygonati Odorati, Fructus Lycii, the Caulis Sargentodoxae of above-mentioned weight are put into the container of boiling medicine and add 4 times of amounts of water, intense fire decocts boiling, for the first time decoction liquor of leaching is crossed in slow fire boiling 20 minutes.The medicinal residues that filter are added 2 times of amounts of water, and intense fire decocts boiling, and slow fire boiling 20 minutes is filtered, and gets for the second time decoction liquor;
3, merge twice decoction liquor, intense fire was used slow fire boiling 10 minutes after decocting boiling again, was condensed into extract;
4, extract sprayed on enlightening ditch Fructus Rosae Normalis, Fructus Chaenomelis, Fructus Carthami tinctorii fine powder, fully mix thoroughly, the granule electuary, dry after sterilization packaging, every bag 4.5 gram.
Medicine of the present invention has invigorating the stomach and promoting digestion, blood circulation promoting and blood stasis dispelling, and dampness removing reduces phlegm, cholesterol reducing, blood sugar lowering, blood fat, the function of expansion and vessel softening is used for the treatment of hypertension, hyperlipidemia, hyperglycemia instant effect take obesity as feature, good effect, cure rate is high.
The specific embodiment
Further set forth beneficial effect of the present invention below by test example, these test examples comprise animal experiment and clinical observation material.
The report of [test example 1] animal toxicity test
Get 40 of new zealand rabbits, body weight 2.0-2.5kg, the male and female dual-purpose is divided into two groups, and 20 every group, wherein one group is the normal amount test group, and another group is the super quantity test group.The medication of normal amount group is 10ml/kg, and the excess group is 20ml/kg, and administering mode is the administration by gavage administration, and every day, each once serve on a week sooner or later, observed medication reaction every day.The result shows: two groups of rabbit diet activities are normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data:
Accept outpatient service obesity, three-hypers Metabolic Syndrome Patients 216 examples for medical treatment, 15 example and premature coronary heart diseases wherein, 11 examples are with sequal of cerebrovascular diseases, male 102 examples in 216 examples, women 114 examples, age 40-50 year 42 examples, 51-60 year 98 examples, 61-70 year 62 examples, 14 examples more than 70 years old.Course of disease 2-15.
2, diagnostic criteria:
The three-hypers metabolic syndrome is mainly in the middle-older patient more than 40 years old, and the multiple focus of patient takes place frequently.
216 examples are except having the above hospital inspection list in county, clinical symptoms: be obesity, dizziness, headache, nose heave dizzy, weak, breathe hard, uncomfortable in chest, numb limbs and tense tendons, palpitation and insomnia, susceptible to lose temper due to restlessness, chest and hypochondrium etc., sequal of cerebrovascular diseases patient speech disorder, facial paralysis, extremity are unsuccessful etc.
3, therapeutic modality:
Every day secondary, each 1 bag, warm boiled water, two months is a course for the treatment of, serve on 2-3 the course for the treatment of.
4, efficacy assessment standard:
Produce effects: patient's transference cure, body constitution recover normal, follow up a case by regular visits to half a year without the recidivist;
Take a turn for the better: patient body recovers normally substantially, and body constitution progressively takes a turn for the better;
Invalid: as not reach improvement standard person.
5, therapeutic effect:
Obesity: 216 routine patients are 151 routine produce effects (standard of produce effects is to be man 25, woman 24 with reference to the Body Mass Index arm's length standard that formulate the Asian-Pacific area) wherein, and obesity symptom disappears, and Body Mass Index is normal, man 25, woman 24; 60 examples take a turn for the better, and obesity symptom disappears substantially; 5 examples are invalid, and total effective rate is 97.68%.
Hyperlipemia: 216 routine patients are 135 routine produce effects wherein, serum cholesterol, triglyceride, three indexs of high density lipoprotein within normal range, sensation of oppression over the chest with shortness of breath, numb limbs and tense tendons, dizzy nose heave, the transference cure such as the abundant expectoration mouth is sticking.79 examples take a turn for the better, and three indexs approach normally, and symptom disappears substantially.Clinical symptoms is improved greatly, invalid 2 examples, and total effective rate is 99.07%.
Hypertension: 216 routine patients are 113 routine produce effects wherein, and more than 1 year, headache is dizzy within normal range for blood pressure stabilization, the cardio palmus shape disappears.98 examples take a turn for the better, and blood pressure approaches normal, and clinical symptoms disappears substantially, and 5 examples are invalid, and total effective rate is 97.68%.
Hyperglycemia: 216 routine patients are 72 routine produce effects wherein, fasting glucose＜6.2mmo1/L, 2 hours blood glucoses＜7.3mmol/L after meal, the clinical symptoms aching pain in waist and back, limb fiber crops limb is painful, dry mouth and throat, weak, breathe hard, spontaneous sweating, thirst and liking drink, stool unites to disappear.102 examples take a turn for the better, fasting glucose＜7.2mmo1/L, and 2 hours blood glucoses, 8.3 mmo1/L after meal, symptom disappears substantially.36 examples progressively take a turn for the better, fasting glucose＜8.3 mmo1/L, and 2 hours blood glucoses＜10 mmo1/L after meal, partial symptoms disappears, invalid 6 examples, total effective rate is 97.22%.
Coronary heart disease: 216 routine patients wherein 15 examples have 11 routine produce effects with the coronary disease patient after treatment, and it is normal that electrocardiogram recovers, and angina pectoris, cardiopalmus, the cardinal symptom uncomfortable in chest of breathing hard disappear, and 2 routine electrocardiograms improve, and cardinal symptom alleviates, invalid 2 examples, and total effective rate is 86.66%.
Cerebrovascular: 216 routine patients wherein 11 routine sequal of cerebrovascular diseases persons treat rear 7 routine produce effects, and clinical symptom disappearance is recovered orthobiosis, and 2 routine cardinal symptoms disappear substantially, and quality of life improves greatly, invalid 2 examples, and total effective rate is 81.81%.
Claims (3)
1. one kind three is stung the electuary that falls three-hypers, and it is characterized in that: it is comprised of the crude drug in the following weight scope:
Enlightening ditch Fructus Rosae Normalis 15-25 gram Fructus Chaenomelis 8-12 gram Seem Lablab Album 8-12 gram
Radix rosae multiflorae 8-12 gram Radix Cudraniae 8-12 gram Folium Rosae Normalis 5-10 gram
Fructus Citri Sarcodactylis 5-10 gram Radix Pseudostellariae 8-12 gram Fructus Tonnae Sinensis 5-10 gram
Radix Rubiae 8-12 gram Fructus Carthami tinctorii 2-5 gram Semen Ziziphi Spinosae 8-12 gram
Cortex Lycii 8-12 gram Herba Taxilli 8-12 gram Radix Puerariae 8-12 gram
Tremella 5-10 gram Ramulus Mori 8-12 gram Radix Angelicae Pubescentis 2-5 gram
Rhizoma Alismatis 5-8 Ke pivot holds 8-12 gram Rhizoma Polygonati Odorati 8-12 gram
Fructus Lycii 5-10 gram Caulis Sargentodoxae 8-12 gram.
2. electuary according to claim 1, wherein the consumption of each crude drug is:
Enlightening ditch Fructus Rosae Normalis 18 gram Fructus Chaenomelis 9 gram Seem Lablab Albums 9 grams
Radix rosae multiflorae 9 gram Radix Cudraniaes 9 gram Folium Rosae Normaliss 6 grams
Fructus Citri Sarcodactylis 6 gram Radix Pseudostellariaes 9 gram Fructus Tonnae Sinensis 6 grams
Radix Rubiae 6 gram Fructus Carthami tinctoriis 3 gram Semen Ziziphi Spinosaes 9 grams
Cortex Lycii 9 gram Herba Taxillis 9 gram Radix Puerariaes 9 grams
Tremella 6 gram Ramulus Moris 9 gram Radix Angelicae Pubescentiss 3 grams
Rhizoma Alismatis 6 Ke pivots hold 9 gram Rhizoma Polygonati Odorati, 9 grams
Fructus Lycii 6 gram Caulis Sargentodoxae 9 grams.
3. the preparation method of described electuary according to claim 1 and 2, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) enlightening ditch Fructus Rosae Normalis: choose high-quality Fructus Rosae Normalis fresh fruit, clear water is cleaned, and section is dried;
(2) Fructus Chaenomelis: choose high-quality Fructus Chaenomelis fresh fruit, clear water is cleaned, and section is dried;
(3) Seem Lablab Album: choose clean impurity, put in the boiling water and slightly boil, heave, softly pull out for degree to planting skin, immerse in the cold water, slough skin, dry;
(4) Radix rosae multiflorae: choose clean impurity, clean and dry;
(5) Radix Cudraniae: clean, run through, oblique section dries;
(6) Folium Rosae Normalis: choose clean impurity, dry;
(7) Fructus Citri Sarcodactylis: choose decontamination, after the water spray profit, chopping is dried;
(8) Radix Pseudostellariae: extract fibrous root, dry;
(9) Fructus Tonnae Sinensis: gather autumn, dries;
(10) Radix Rubiae: choose clean impurity, remove Lu Miao, clean, run through rear timely section, dry;
(11) Fructus Carthami tinctorii: choose clean impurity, dry;
(12) Semen Ziziphi Spinosae: former medicine is put into the bamboo square-bottomed bamboo basket, sinks in the clear water cylinder, and core is kept afloat, and shell is heavy water-bed, will sting core and pull out, dries;
(13) Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting;
(14) Herba Taxilli: former medicine washes, and runs through, and cutting is dried;
(15) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;
(16) Tremella: choose decontamination, dry or dry;
(17) Ramulus Mori: choose decontamination, clean, be soaked in water, after running through, cutting is dried;
(18) Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through rear section, drying;
(19) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is dried;
(20) Herba Polygoni Avicularis: remove impurity and root, clean, moisten softly, cutting is dried;
(21) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
(22) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;
(23) Caulis Sargentodoxae: be soaked in water, clean spare, run through, section is dried;
(2) preparation
(1) for preventing losing of the active ingredient such as VC, get fresh fruit fast low temperature 50-60 ℃ oven dry within the shortest time of enlightening ditch Fructus Rosae Normalis and the Fructus Chaenomelis of above-mentioned weight, wear into fine powder with Fructus Carthami tinctorii;
(2) Seem Lablab Album, Radix rosae multiflorae, Radix Cudraniae, Folium Rosae Normalis, Fructus Citri Sarcodactylis, Radix Pseudostellariae, Fructus Tonnae Sinensis, Radix Rubiae, Semen Ziziphi Spinosae, Cortex Lycii, Herba Taxilli, Radix Puerariae, Tremella, Ramulus Mori, Radix Angelicae Pubescentis, Rhizoma Alismatis, Herba Polygoni Avicularis, Rhizoma Polygonati Odorati, Fructus Lycii, the Caulis Sargentodoxae of above-mentioned weight are put into the container of boiling medicine and add 4 times of amounts of water, intense fire decocts boiling, slow fire boiling 20 minutes, cross for the first time decoction liquor of leaching, the medicinal residues that filter are added 2 times of amounts of water, intense fire decocts boiling, slow fire boiling 20 minutes, filter, get for the second time decoction liquor;
(3) merge twice decoction liquor, intense fire was used slow fire boiling 10 minutes after decocting boiling again, was condensed into extract;
(4) extract sprayed on enlightening ditch Fructus Rosae Normalis, Fructus Chaenomelis, Fructus Carthami tinctorii fine powder, fully mix thoroughly, the granule electuary, dry after sterilization packaging, every bag 4.5 gram.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103651945A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health oil with efficacy of promoting blood circulation to remove meridian obstruction |
| CN103704603A (en) * | 2013-12-13 | 2014-04-09 | 田世伟 | Noodle suitable for diabetes patients and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1288945A (en) * | 1999-09-17 | 2001-03-28 | 湖北三峡学院医学院 | Tonic wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1288945A (en) * | 1999-09-17 | 2001-03-28 | 湖北三峡学院医学院 | Tonic wine |
Non-Patent Citations (1)
| Title |
|---|
| 朱学良等: "《第一要素胶囊对高血脂模型大鼠降血脂作用的研究》", 《中国食品工业》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103651945A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health oil with efficacy of promoting blood circulation to remove meridian obstruction |
| CN103704603A (en) * | 2013-12-13 | 2014-04-09 | 田世伟 | Noodle suitable for diabetes patients and preparation method thereof |
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