CN103656290B - Medicine for treating optic atrophy and preparation method of medicine - Google Patents

Medicine for treating optic atrophy and preparation method of medicine Download PDF

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CN103656290B
CN103656290B CN201310665428.3A CN201310665428A CN103656290B CN 103656290 B CN103656290 B CN 103656290B CN 201310665428 A CN201310665428 A CN 201310665428A CN 103656290 B CN103656290 B CN 103656290B
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radix
rhizoma
fructus
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CN103656290A (en
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张有富
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Abstract

The invention discloses a medicine for treating optic atrophy and a preparation method of the medicine. The medicine is prepared mainly from prepared rehmannia, cicada slough, Chinese angelica, astragalus membranaceus, pinellia ternate, frankincense, myrrh, mulberry, scrophularia ningpoensis and other medicines in a certain weight ratio. The medicine has the functions of soothing liver and improving sight, clearing heat and removing toxicity, cooling blood and nourishing liver, is quick in response and good in curative effect when used for treating optic atrophy, and does not have toxic or side effect.

Description

A kind of medicine for the treatment of optic atrophy and preparation method thereof
Technical field
The present invention relates to a kind of medicine being used for the treatment of optic atrophy and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Optic atrophy refers to and causes retinal ganglial cells and its aixs cylinder generation pathological changes by disease, and the one causing optic nerve all to attenuate is formed to learn and changes, and generally betides the Ganglion cell axon degeneration between retina to lateral geniculate body.Optic atrophy is the final result of optic nerve disease damage, shows as degeneration and the disappearance of optic nerve fiber, conduction function obstacle, occurs that the visual field changes, and visual deterioration is also lost.Generally be divided into constitutional and Secondary cases two class.Examination of ocular fundus is yellowish or pale asphyxia depending on nipple color as seen, and boundary is fuzzy, and physiological depression disappears, and blood vessel attenuates.At present, western medicine optic atrophy poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating optic atrophy in people.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment optic atrophy, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating optic atrophy.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Rehmanniae Preparata, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating optic atrophy.Wherein select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Periostracum Cicadae to be because its property sweet-salty, cool, enter lung, Liver Channel, have loose wind heat, lung qi dispersing, determine the function of convulsion, control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, and rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Olibanum to be that temperature, enters the heart, liver, spleen channel, have regulating qi and activating blood, analgesic therapy because its nature and flavor are worked hard, chase after the function of poison, control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Myrrha is selected to be that flat, enter Liver Channel, have loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and fall damage, incised wound, muscles and bones, trusted subordinate all Tong , mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye because its nature and flavor are bitter.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, have tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow the function of liquid, control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizzy, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Herba Ecliptae to be because its nature and flavor picric acid, cool, enter liver, kidney channel, have removing heat from blood, hemostasis, the kidney invigorating, the function of tonifying YIN, controls haematemesis, hemoptysis, epistaxis, and hematuria is had blood in stool, dysentery, and knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia , mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, profit cardiopulmonary, the function of bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, and muscles and bones is weak, rheumatalgia, wind favus disease.Radix Rubiae is selected to be that cold, enter the heart, Liver Channel, have promoting the circulation of blood to stop blooding, dredge the meridian passage, eliminating phlegm and stopping cough, control haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, property tracheitis because its nature and flavor are bitter.Fructus Corni is selected to be that tepor, has invigorating the liver and kidney, and the function of arresting seminal emission gas, controls sexual impotence, and seminal emission, deficiency of the liver cold and heat, the heart shakes scattered pulse because its nature and flavor acid.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle , Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.Select Flos Buddlejae to be because its nature and flavor are sweet, cool, enter Liver Channel, dispel the wind, removing heat from blood, profit liver, the function of improving eyesight, controls conjunctival congestion and swelling pain, many tear photophobia, optic atrohic blindness cataracta, the rotten eye of wind string.Semen Celosiae is selected to be that cool, enter Liver Channel, heat of dispeling the wind, the function of clearing away liver-fire, controls conjunctival congestion and swelling pain, hides from view, hypertension, epistaxis, skin wind heat pruritus, mange because its nature and flavor are bitter.Select Fructus Tribuli to be because its nature and flavor toil, temperature, enter liver, lung meridian, have loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, the function of promoting the circulation of blood, controls headache, itching over the body, and conjunctival congestion swells nebula, and fullness in the chest, cough with dyspnea , mass in the abdomen, breast is difficult, carbuncle, scrofula.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid.Select Hirudo to be because the salty hardship of its nature and flavor, flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, control blood-retention , mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis , lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Spica Prunellae to be because its nature and flavor toil, cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select Pollen Typhae to be because its nature and flavor are sweet arduous, cool, enter liver, heart channel, have cooling blood for hemostasis, the function of activating blood circulation and dissipating blood stasis, raw with controlling amenorrhea stomachache, postpartum stagnation is had a pain, and falls that to flutter blood vexed, furuncle toxic swelling, fries black emesis blood, epistaxis, metrorrhagia, rush down blood, hematuria, dysentery, leukorrhagia, external treatment congenital deformity of the tongue, aphtha, Ting discharging ear, hemorrhage in ear, uncontrolled urination is itched.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Rhizoma Polygonati Odorati to be that flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst because its nature and flavor are sweet, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Rhizoma Imperatae to be sweet because of its nature and flavor, cold, enter lung, stomach, small intestine meridian, have removing heat from blood, hemostasis, heat clearing away, the function of diuresis, controls calentura excessive thirst, spits blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Rehmanniae Preparata 5-15 gram of Periostracum Cicadae 10-20 gram of Radix Angelicae Sinensis 5-15 gram
Radix Astragali 5-15 gram of Rhizoma Pinelliae 10-20 gram of Olibanum 5-15 gram
Myrrha 5-15 gram of Fructus Mori 10-20 gram of Radix Scrophulariae 5-15 gram
Fructus Ligustri Lucidi 10-20 gram of Herba Ecliptae 15-25 gram of Radix Salviae Miltiorrhizae 5-15 gram
Rhizoma Polygonati 10-20 gram of Radix Rubiae 15-25 Keshan Fructus Corni 5-15 gram
Poria 10-20 gram of Cortex Moutan 15-25 gram of Flos Buddlejae 5-15 gram
Semen Celosiae 10-20 gram of Fructus Tribuli 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Hirudo 10-20 gram of Lumbricus 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Spica Prunellae 10-20 gram of Pollen Typhae 15-25 gram of Rhizoma Alismatis 15-25 gram
Rhizoma Polygonati Odorati 10-20 gram of Radix Ophiopogonis 15-25 gram of Rhizoma Imperatae 15-25 gram
Preferable amount is
Radix Rehmanniae Preparata 10 grams of Periostracum Cicadaes 15 grams of Radix Angelicae Sinensis 10 grams
The Radix Astragali 10 grams of Rhizoma Pinelliaes 15 grams of Olibanums 10 grams
Myrrha 10 grams of Fructus Moris 15 grams of Radix Scrophulariaes 10 grams
Fructus Ligustri Lucidi 15 grams of Herba Ecliptaes 20 grams of Radix Salviae Miltiorrhizaes 10 grams
Rhizoma Polygonati 15 grams of Radix Rubiae 20 Keshan Fructus Corni 10 grams
Poria 15 grams of Cortex Moutans 20 grams of Flos Buddlejaes 10 grams
Semen Celosiae 15 grams of Fructus Tribulis 20 grams of Fructus Schisandrae Chinensis 20 grams
Hirudo 15 grams of Lumbricuss 20 grams of Rhizoma Polygoni Cuspidati 20 grams
Spica Prunellae 15 grams of Pollen Typhaes 20 grams of Rhizoma Alismatis 20 grams
Rhizoma Polygonati Odorati 20 grams of Rhizoma Imperataes, 15 grams of Radix Ophiopogonis 20 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
2, Periostracum Cicadae: pick decontamination, cleans and dries;
3, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
4, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
5, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
6, Olibanum: pick the sub-impurity of shakeout;
7, Myrrha: pick decontamination, breaks into fragment;
8, Fructus Mori: wash, picks decontamination, extracts long handle, dries;
9, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;
10, Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
11, Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
12, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
13, Rhizoma Polygonati: clean earth, slightly profit, section, dries;
14, Radix Rubiae: pick clean impurity, removing Lu Miao, cleans, runs through rear timely section, dry;
15, Fructus Corni: clean, except removal core and impurity, dry;
16, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
17, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
18, Flos Buddlejae: pick decontamination, well sifted dirt;
19, Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, and removing impurity, dries;
20, Fructus Tribuli: silt is removed in drift, the hard thorn that Ex-all is residual;
21, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
22, Hirudo: clean, vexed soft, cutting, dries;
23, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
24, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
25, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
26, Pollen Typhae: rub broken caking, sieve, removing impurity;
27, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
28, Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
29, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
30, Rhizoma Imperatae: pick clean impurity, clean, micro-profit, cutting, dries, clean chip of winnowing with a dustpan.
Two, prepare
1, the Radix Rehmanniae Preparata of described weight, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor.
2, add water the medicinal residues after filtration 4 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 3 doses to take.
Medicine of the present invention has soothing the liver improving eyesight, heat-clearing and toxic substances removing, removing heat from blood, and the function of profit liver, is used for the treatment of optic atrophy, short treating period, instant effect, has no side effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy optic atrophy of the present invention
1, physical data
Accept optic atrophy totally 205 examples for medical treatment.
2, diagnostic criteria
1. primary optic atrophy
Often because of caused by the reasons such as retrobulbar neuritis, hereditary optic neuropathy (Leber is sick), orbital internal tumor compressing, wound, neurotoxin.After these pathological changes occur in ball.
2. secondary optic atrophy
Common are papillitis optica, papilloedema, retina venation inflammation, retinitis pigmentosa, retinal centre move film obstruction, quinism, anterior ischemic optic neuropathy, glaucoma etc.
Clinical manifestation: main manifestations visual deterioration and optic disc are canescence or pale.Can occur crack shape or wedge-shaped defect during optic disc peripheral nerve fibrous layer disease damage, the former becomes comparatively black, for layer of retina,pigmentary exposes; The latter, in more red, is choroid exposure.If infringement betides lower edge district on optic disc, then more easy to identify, because this district's nerve fibre layer thickens especially, if disease damage is away from optic disc district, because these regional nerve Conductivity of Fibers are thinning, then not easily find.Often point out nerve fibre layer to have pathological changes with focal atrophy around optic disc, be nerve fibre layer thinning in this district caused by.
Although conventional ophthalmofundoscopy can find, more easily check with taking pictures without red smooth ophthalmoscope and optical fundus.Optic disc thin vessels is generally 9 ~ 10, if optic atrophy, these thin vessels numbers will reduce.Attenuate with narrow, inaccessible with the visible arteria retina of fashion.
Optic atrophy divides constitutional and Secondary cases two kinds: the former optic disc boundary is clear, physiological depression and sieve plate visible; The latter's boundary is fuzzy, physiological depression and sieve plate invisible.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 6 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: optic atrophy symptom disappears, observe half a year without bounce-back person;
Take a turn for the better: optic atrophy symptom is obviously improved, and body constitution progressively strengthens;
Invalid: optic atrophy symptom, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy optic atrophy 205 example of the present invention, effective 196 examples of result, obvious effective rate is 95.61%, and take a turn for the better 6 examples, and improvement rate is 2.93%, and invalid 3 examples, total effective rate is 98.54%.

Claims (3)

1. treat a medicine for optic atrophy, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Rehmanniae Preparata 5-15 gram of Periostracum Cicadae 10-20 gram of Radix Angelicae Sinensis 5-15 gram
Radix Astragali 5-15 gram of Rhizoma Pinelliae 10-20 gram of Olibanum 5-15 gram
Myrrha 5-15 gram of Fructus Mori 10-20 gram of Radix Scrophulariae 5-15 gram
Fructus Ligustri Lucidi 10-20 gram of Herba Ecliptae 15-25 gram of Radix Salviae Miltiorrhizae 5-15 gram
Rhizoma Polygonati 10-20 gram of Radix Rubiae 15-25 Keshan Fructus Corni 5-15 gram
Poria 10-20 gram of Cortex Moutan 15-25 gram of Flos Buddlejae 5-15 gram
Semen Celosiae 10-20 gram of Fructus Tribuli 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Hirudo 10-20 gram of Lumbricus 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Spica Prunellae 10-20 gram of Pollen Typhae 15-25 gram of Rhizoma Alismatis 15-25 gram
Rhizoma Polygonati Odorati 10-20 gram of Radix Ophiopogonis 15-25 gram of Rhizoma Imperatae 15-25 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Rehmanniae Preparata 10 grams of Periostracum Cicadaes 15 grams of Radix Angelicae Sinensis 10 grams
The Radix Astragali 10 grams of Rhizoma Pinelliaes 15 grams of Olibanums 10 grams
Myrrha 10 grams of Fructus Moris 15 grams of Radix Scrophulariaes 10 grams
Fructus Ligustri Lucidi 15 grams of Herba Ecliptaes 20 grams of Radix Salviae Miltiorrhizaes 10 grams
Rhizoma Polygonati 15 grams of Radix Rubiae 20 Keshan Fructus Corni 10 grams
Poria 15 grams of Cortex Moutans 20 grams of Flos Buddlejaes 10 grams
Semen Celosiae 15 grams of Fructus Tribulis 20 grams of Fructus Schisandrae Chinensis 20 grams
Hirudo 15 grams of Lumbricuss 20 grams of Rhizoma Polygoni Cuspidati 20 grams
Spica Prunellae 15 grams of Pollen Typhaes 20 grams of Rhizoma Alismatis 20 grams
Rhizoma Polygonati Odorati 20 grams of Rhizoma Imperataes, 15 grams of Radix Ophiopogonis 20 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
(2) Periostracum Cicadae: pick decontamination, cleans and dries;
(3) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
(4) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
(5) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
(6) Olibanum: pick the sub-impurity of shakeout;
(7) Myrrha: pick decontamination, breaks into fragment;
(8) Fructus Mori: wash, picks decontamination, extracts long handle, dries;
(9) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;
(10) Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
(11) Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
(12) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
(13) Rhizoma Polygonati: clean earth, slightly profit, section, dries;
(14) Radix Rubiae: pick clean impurity, removing Lu Miao, cleans, runs through rear timely section, dry;
(15) Fructus Corni: clean, except removal core and impurity, dry;
(16) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(17) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
(18) Flos Buddlejae: pick decontamination, well sifted dirt;
(19) Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, and removing impurity, dries;
(20) Fructus Tribuli: silt is removed in drift, the hard thorn that Ex-all is residual;
(21) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(22) Hirudo: clean, vexed soft, cutting, dries;
(23) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
(24) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
(25) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
(26) Pollen Typhae: rub broken caking, sieve, removing impurity;
(27) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
(28) Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
(29) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
(30) Rhizoma Imperatae: pick clean impurity, clean, micro-profit, cutting, dries, clean chip of winnowing with a dustpan;
(2) prepare
(1) Radix Rehmanniae Preparata of described weight, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor;
(2) add water the medicinal residues after filtration 4 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor;
(3) merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 3 doses to take.
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CN109922798A (en) 2016-09-08 2019-06-21 瑞吉纳拉制药公司 The composition of acidic extraction object including frankincense gum and its purposes for treating optic neuropathy
EA201990560A1 (en) 2016-09-08 2019-09-30 Регенера Фарма Лтд. COMPOSITIONS CONTAINING TRITERPENOIDS AND THEIR APPLICATION FOR TREATMENT OF OPTICAL NEUROPATHY
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840126A (en) * 2006-02-06 2006-10-04 李功淮 Chinese medicine for treating amblyopia and myopia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840126A (en) * 2006-02-06 2006-10-04 李功淮 Chinese medicine for treating amblyopia and myopia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
马吉丹,等.视神经萎缩的中医治疗概况.《实用中西医结合临床》.2010,第10卷(第1期),89-91. *

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