CN103656290A - Medicine for treating optic atrophy and preparation method of medicine - Google Patents
Medicine for treating optic atrophy and preparation method of medicine Download PDFInfo
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- CN103656290A CN103656290A CN201310665428.3A CN201310665428A CN103656290A CN 103656290 A CN103656290 A CN 103656290A CN 201310665428 A CN201310665428 A CN 201310665428A CN 103656290 A CN103656290 A CN 103656290A
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Abstract
The invention discloses a medicine for treating optic atrophy and a preparation method of the medicine. The medicine is prepared mainly from prepared rehmannia, cicada slough, Chinese angelica, astragalus membranaceus, pinellia ternate, frankincense, myrrh, mulberry, scrophularia ningpoensis and other medicines in a certain weight ratio. The medicine has the functions of soothing liver and improving sight, clearing heat and removing toxicity, cooling blood and nourishing liver, is quick in response and good in curative effect when used for treating optic atrophy, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of optic atrophy and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Optic atrophy refers to by disease and causes retinal ganglial cells and its aixs cylinder generation pathological changes, causes a kind of formation that optic nerve all attenuates to change, and generally betides retina to the Ganglion cell axon degeneration between lateral geniculate body.Optic atrophy is the final result of optic nerve disease damage, shows as degeneration and the disappearance of optic nerve fiber, and conduction function obstacle occurs that the visual field changes, and visual deterioration is also lost.Generally be divided into constitutional and Secondary cases two classes.Examination of ocular fundus is yellowish or pale asphyxia depending on nipple color as seen, and boundary is fuzzy, and physiological depression disappears, and blood vessel attenuates etc.At present, western medicine optic atrophy poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effective treatment optic atrophy in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment optic atrophy, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat optic atrophy.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Rehmanniae Preparata, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating optic atrophy.Wherein select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enters liver, kidney channel, has YIN nourishing, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, waist knee flaccidity, and chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision.Selecting Periostracum Cicadae is because its property sweet-salty, cool, enters lung, Liver Channel, has loose wind heat, and lung qi dispersing determine the function of convulsion, controls affection due to external wind and heat, cough hoarseness, and measles is thoroughly not smooth, rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select Olibanum to be because its nature and flavor are arduous, temperature, enters the heart, liver, spleen channel, has regulating qi and activating blood, and analgesic therapy chases after malicious function, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select Myrrha to be because its nature and flavor are bitter, flat, enter Liver Channel, there is loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and falls damage, incised wound, muscles and bones, all Tong ， of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, there is tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows the function of liquid, controls hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, controls calentura excessive thirst, sends out speckle, and hectic fever due to YIN-deficiency consumptive fever, sleeps not peaceful night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Herba Ecliptae to be because its nature and flavor picric acid is cool, enter liver, kidney channel, have removing heat from blood, hemostasis, the kidney invigorating, the function of tonifying YIN, controls haematemesis, hemoptysis, epistaxis, hematuria, has blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, profit cardiopulmonary, the function of bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones is weak, rheumatalgia, wind favus disease.Select Radix Rubiae to be because its nature and flavor are bitter, cold, enter the heart, Liver Channel, there is promoting the circulation of blood hemostasis, dredge the meridian passage, eliminating phlegm and stopping cough, controls haematemesis, epistaxis, hematuria, has blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, property tracheitis.Select Fructus Corni to be because its nature and flavor are sour, tepor, has invigorating the liver and kidney, and the function of arresting seminal emission gas, controls sexual impotence, seminal emission, and deficiency of the liver cold and heat, the heart shakes scattered pulse.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Flos Buddlejae to be because its nature and flavor are sweet, cool, enter Liver Channel, dispel the wind, removing heat from blood, profit liver, the function of improving eyesight, controls conjunctival congestion and swelling pain, many tear photophobia, optic atrohic blindness cataracta, the rotten eye of wind string.Select Semen Celosiae to be because its nature and flavor are bitter, cool, enter Liver Channel, the heat of dispeling the wind, the function of clearing away liver-fire, controls conjunctival congestion and swelling pain, hides from view, hypertension, epistaxis, skin wind heat pruritus, mange.Selecting Fructus Tribuli is because its nature and flavor toil, and temperature, enters liver, lung meridian, has loose wind, improving eyesight, and the therapeutic method to keep the adverse QI flowing downwards, the function of promoting the circulation of blood, controls headache, itching over the body, the conjunctival congestion nebula that swell, fullness in the chest, cough with dyspnea ， mass in the abdomen, breast difficulty, carbuncle, scrofula.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Hirudo to be because the salty hardship of its nature and flavor is flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, controls blood-retention ， mass in the abdomen, gathers, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, there is heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds malignant boil tinea disease.Select Spica Prunellae to be because its nature and flavor toil is cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select Pollen Typhae to be because its nature and flavor are sweet arduous, cool, enter liver, heart channel, have cooling blood for hemostasis, the function of activating blood circulation and dissipating blood stasis, raw suffers from abdominal pain with controlling amenorrhea, and postpartum stagnation is had a pain, and falls that to flutter blood vexed, furuncle toxic swelling, fries black emesis blood, epistaxis, metrorrhagia, rush down blood, hematuria, dysentery, leukorrhagia, external treatment congenital deformity of the tongue, aphtha, Ting discharging ear, hemorrhage in ear, uncontrolled urination is itched.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst, controls calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.It is sweet because of its nature and flavor, cold selecting Rhizoma Imperatae, enters lung, stomach, small intestine meridian, has removing heat from blood, hemostasis, and heat clearing away, the function of diuresis, controls calentura excessive thirst, spits blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Rehmanniae Preparata 5-15 gram of Periostracum Cicadae 10-20 gram of Radix Angelicae Sinensis 5-15 gram
Radix Astragali 5-15 gram of Rhizoma Pinelliae 10-20 gram of Olibanum 5-15 gram
Myrrha 5-15 gram of Fructus Mori 10-20 gram of Radix Scrophulariae 5-15 gram
Fructus Ligustri Lucidi 10-20 gram of Herba Ecliptae 15-25 gram of Radix Salviae Miltiorrhizae 5-15 gram
Rhizoma Polygonati 10-20 gram of Radix Rubiae 15-25 Keshan Fructus Corni 5-15 gram
Poria 10-20 gram of Cortex Moutan 15-25 gram of Flos Buddlejae 5-15 gram
Semen Celosiae 10-20 gram of Fructus Tribuli 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Hirudo 10-20 gram of Lumbricus 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Spica Prunellae 10-20 gram of Pollen Typhae 15-25 gram of Rhizoma Alismatis 15-25 gram
Rhizoma Polygonati Odorati 10-20 gram of Radix Ophiopogonis 15-25 gram of Rhizoma Imperatae 15-25 gram
Preferable amount is
10 grams of 15 grams of Radix Angelicae Sinensis of 10 grams of Periostracum Cicadaes of Radix Rehmanniae Preparata
10 grams of 15 grams of Olibanums of 10 grams of Rhizoma Pinelliaes of the Radix Astragali
10 grams of 15 grams of Radix Scrophulariaes of 10 grams of Fructus Moris of Myrrha
10 grams of 20 grams of Radix Salviae Miltiorrhizaes of 15 grams of Herba Ecliptaes of Fructus Ligustri Lucidi
10 grams of 15 grams of Radix Rubiae of Rhizoma Polygonati, 20 Keshan Fructus Corni
10 grams of 20 grams of Flos Buddlejaes of 15 grams of Cortex Moutans of Poria
20 grams of 20 grams of Fructus Schisandrae Chinensis of 15 grams of Fructus Tribulis of Semen Celosiae
20 grams of 20 grams of Rhizoma Polygoni Cuspidati of 15 grams of Lumbricuss of Hirudo
20 grams of 20 grams of Rhizoma Alismatis of 15 grams of Pollen Typhaes of Spica Prunellae
20 grams of Rhizoma Polygonati Odorati 20 grams of Rhizoma Imperataes, 15 grams of Radix Ophiopogonis
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
2, Periostracum Cicadae: choose decontamination, clean and dry;
3, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air, and section is dried;
4, the Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
5, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
6, Olibanum: choose the sub-impurity of shakeout;
7, Myrrha: choose decontamination, break into fragment;
8, Fructus Mori: wash, choose decontamination, extract long handle, dry;
9, Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries;
10, Fructus Ligustri Lucidi: choose decontamination, clean, dry;
11, Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;
12, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
13, Rhizoma Polygonati: clean earth, slightly profit, cuts into slices, and dries;
14, Radix Rubiae: choose clean impurity, remove Lu Miao, clean, run through rear timely section, dry;
15, Fructus Corni: clean, except removal core and impurity, dry;
16, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
17, Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
18, Flos Buddlejae: choose decontamination, well sifted dirt;
19, Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;
20, Fructus Tribuli: float silt, the hard thorn that Ex-all is residual;
21, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
22, Hirudo: clean, vexed soft, cutting, dries;
23, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
24, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
25, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
26, Pollen Typhae: rub broken caking, sieve, remove impurity;
27, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
28, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
29, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
30, Rhizoma Imperatae: choose clean impurity, clean, micro-profit, cutting, dries, the clean chip of winnowing with a dustpan.
Two, preparation
1, the Radix Rehmanniae Preparata of described weight, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine are decocted with water to secondary, add for the first time 8 times of amounts of water, soak after 200 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 35 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues after filtering are added to 4 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time.
3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 3 doses and takes.
Medicine of the present invention has soothing the liver improving eyesight, heat-clearing and toxic substances removing, and removing heat from blood, the function of profit liver, is used for the treatment of optic atrophy, short treating period, instant effect, has no side effect.
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.3kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy optic atrophy of the present invention
1, physical data
Accept optic atrophy totally 205 examples for medical treatment.
2, diagnostic criteria
1. primary optic atrophy
Often because of due to the reasons such as retrobulbar neuritis, hereditary optic neuropathy (Leber is sick), orbital internal tumor compressing, wound, neurotoxin.These pathological changes occur in after ball.
2. secondary optic atrophy
Common are papillitis optica, papilloedema, retina venation inflammation, retinitis pigmentosa, the moving film obstruction of retinal centre, quinism, anterior ischemic optic neuropathy, glaucoma etc.
Clinical manifestation: main manifestations visual deterioration and optic disc are canescence or pale.During optic disc peripheral nerve fibrous layer disease damage, can occur crack shape or wedge-shaped defect, the former becomes compared with black, for layer of retina,pigmentary exposes; It is more red that the latter is, for choroid exposes.If infringement betides lower edge district on optic disc, more easy to identify, Yin Gai district nerve fibre layer thickens especially, if disease damage, away from optic disc district, because these region nerve fibers are led attenuation, is difficult for finding.Optic disc around often points out nerve fibre layer to have pathological changes with focal atrophy, is due to nerve fibre layer Gai district's attenuation.
Although conventional ophthalmofundoscopy can find, with the more easily inspection of taking pictures without red smooth ophthalmoscope and optical fundus.The little blood vessel of optic disc is generally 9～10, if optic atrophy, these little number of blood vessel will reduce.With the visible arteria retina of fashion, attenuate with narrow, inaccessible.
Optic atrophy divides two kinds of constitutional and Secondary cases: the former optic disc boundary is clear, and physiological depression and sieve plate are visible; The latter's boundary is fuzzy, and physiological depression and sieve plate are invisible.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 6 courses for the treatment of.
4, efficacy assessment standard
Effective: optic atrophy transference cure, observe half a year without bounce-back person;
Take a turn for the better: optic atrophy symptom is obviously improved, and body constitution progressively strengthens;
Invalid: optic atrophy symptom, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy optic atrophy 205 examples of the present invention, effective 196 examples of result, obvious effective rate is 95.61%, 6 examples that take a turn for the better, and improvement rate is 2.93%, invalid 3 examples, total effective rate is 98.54%.
Claims (3)
1. a medicine for the treatment of optic atrophy, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Rehmanniae Preparata 5-15 gram of Periostracum Cicadae 10-20 gram of Radix Angelicae Sinensis 5-15 gram
Radix Astragali 5-15 gram of Rhizoma Pinelliae 10-20 gram of Olibanum 5-15 gram
Myrrha 5-15 gram of Fructus Mori 10-20 gram of Radix Scrophulariae 5-15 gram
Fructus Ligustri Lucidi 10-20 gram of Herba Ecliptae 15-25 gram of Radix Salviae Miltiorrhizae 5-15 gram
Rhizoma Polygonati 10-20 gram of Radix Rubiae 15-25 Keshan Fructus Corni 5-15 gram
Poria 10-20 gram of Cortex Moutan 15-25 gram of Flos Buddlejae 5-15 gram
Semen Celosiae 10-20 gram of Fructus Tribuli 15-25 gram of Fructus Schisandrae Chinensis 15-25 gram
Hirudo 10-20 gram of Lumbricus 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Spica Prunellae 10-20 gram of Pollen Typhae 15-25 gram of Rhizoma Alismatis 15-25 gram
Rhizoma Polygonati Odorati 10-20 gram of Radix Ophiopogonis 15-25 gram of Rhizoma Imperatae 15-25 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
10 grams of 15 grams of Radix Angelicae Sinensis of 10 grams of Periostracum Cicadaes of Radix Rehmanniae Preparata
10 grams of 15 grams of Olibanums of 10 grams of Rhizoma Pinelliaes of the Radix Astragali
10 grams of 15 grams of Radix Scrophulariaes of 10 grams of Fructus Moris of Myrrha
10 grams of 20 grams of Radix Salviae Miltiorrhizaes of 15 grams of Herba Ecliptaes of Fructus Ligustri Lucidi
10 grams of 15 grams of Radix Rubiae of Rhizoma Polygonati, 20 Keshan Fructus Corni
10 grams of 20 grams of Flos Buddlejaes of 15 grams of Cortex Moutans of Poria
20 grams of 20 grams of Fructus Schisandrae Chinensis of 15 grams of Fructus Tribulis of Semen Celosiae
20 grams of 20 grams of Rhizoma Polygoni Cuspidati of 15 grams of Lumbricuss of Hirudo
20 grams of 20 grams of Rhizoma Alismatis of 15 grams of Pollen Typhaes of Spica Prunellae
20 grams of Rhizoma Polygonati Odorati 20 grams of Rhizoma Imperataes, 15 grams of Radix Ophiopogonis.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;
(2) Periostracum Cicadae: choose decontamination, clean and dry;
(3) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air, and section is dried;
(4) Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
(5) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(6) Olibanum: choose the sub-impurity of shakeout;
(7) Myrrha: choose decontamination, break into fragment;
(8) Fructus Mori: wash, choose decontamination, extract long handle, dry;
(9) Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries;
(10) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(11) Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;
(12) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(13) Rhizoma Polygonati: clean earth, slightly profit, cuts into slices, and dries;
(14) Radix Rubiae: choose clean impurity, remove Lu Miao, clean, run through rear timely section, dry;
(15) Fructus Corni: clean, except removal core and impurity, dry;
(16) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(17) Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
(18) Flos Buddlejae: choose decontamination, well sifted dirt;
(19) Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;
(20) Fructus Tribuli: float silt, the hard thorn that Ex-all is residual;
(21) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(22) Hirudo: clean, vexed soft, cutting, dries;
(23) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
(24) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
(25) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
(26) Pollen Typhae: rub broken caking, sieve, remove impurity;
(27) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
(28) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
(29) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
(30) Rhizoma Imperatae: choose clean impurity, clean, micro-profit, cutting, dries, the clean chip of winnowing with a dustpan;
(2) preparation
(1) Radix Rehmanniae Preparata of described weight, Periostracum Cicadae, Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Pinelliae, Olibanum, Myrrha, Fructus Mori, Radix Scrophulariae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Rubiae, Fructus Corni, Poria, Cortex Moutan, Flos Buddlejae, Semen Celosiae, Fructus Tribuli, Fructus Schisandrae Chinensis, Hirudo, Lumbricus, Rhizoma Polygoni Cuspidati, Spica Prunellae, Pollen Typhae, Rhizoma Alismatis, Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Imperatae medicine are decocted with water to secondary, add for the first time 8 times of amounts of water, soak after 200 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 35 minutes, filter to obtain decoction liquor for the first time;
(2) medicinal residues after filtering are added to 4 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time;
(3) merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 3 doses and takes.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104666599A (en) * | 2015-03-16 | 2015-06-03 | 济南骄泰信息技术有限公司 | Traditional Chinese medicine composition for treating optic atrophy |
| CN105125865A (en) * | 2015-08-25 | 2015-12-09 | 何萍萍 | Traditional Chinese medicine for treating optic atrophy |
| CN106729438A (en) * | 2017-01-30 | 2017-05-31 | 防城港市奥氏蓝科技有限公司 | A kind of medicine of therapeutic community's property retinitis |
| KR20200022929A (en) | 2018-08-24 | 2020-03-04 | 한국식품연구원 | Use of Aralia continentalis extract for eye health |
| US10751347B2 (en) | 2016-09-08 | 2020-08-25 | Regenera Pharma Ltd. | Compositions comprising acidic extracts of mastic gum and uses thereof for treating optic neuropathy |
| US11000562B2 (en) | 2015-03-08 | 2021-05-11 | Regenera Pharma Ltd. | Use of isolated fractions of mastic gum for treating optic neuropathy |
| US11207333B2 (en) | 2016-09-08 | 2021-12-28 | Regenera Pharma Ltd. | Compositions comprising triterpenoids and uses thereof for treating optic neuropathy |
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| CN1840126A (en) * | 2006-02-06 | 2006-10-04 | 李功淮 | Chinese medicine for treating amblyopia and myopia |
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| CN1840126A (en) * | 2006-02-06 | 2006-10-04 | 李功淮 | Chinese medicine for treating amblyopia and myopia |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11000562B2 (en) | 2015-03-08 | 2021-05-11 | Regenera Pharma Ltd. | Use of isolated fractions of mastic gum for treating optic neuropathy |
| CN104666599A (en) * | 2015-03-16 | 2015-06-03 | 济南骄泰信息技术有限公司 | Traditional Chinese medicine composition for treating optic atrophy |
| CN105125865A (en) * | 2015-08-25 | 2015-12-09 | 何萍萍 | Traditional Chinese medicine for treating optic atrophy |
| US10751347B2 (en) | 2016-09-08 | 2020-08-25 | Regenera Pharma Ltd. | Compositions comprising acidic extracts of mastic gum and uses thereof for treating optic neuropathy |
| US11207333B2 (en) | 2016-09-08 | 2021-12-28 | Regenera Pharma Ltd. | Compositions comprising triterpenoids and uses thereof for treating optic neuropathy |
| CN106729438A (en) * | 2017-01-30 | 2017-05-31 | 防城港市奥氏蓝科技有限公司 | A kind of medicine of therapeutic community's property retinitis |
| KR20200022929A (en) | 2018-08-24 | 2020-03-04 | 한국식품연구원 | Use of Aralia continentalis extract for eye health |
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