CN105902867B

CN105902867B - A herbal composition for reducing hypertension, hyperglycemia and hyperlipidemia, and its preparation method

Info

Publication number: CN105902867B
Application number: CN201610416225.4A
Authority: CN
Inventors: 李雪晴
Original assignee: Xi'an Libang Pharmaceutical Co ltd
Current assignee: Xi'an Libang Pharmaceutical Co ltd
Priority date: 2016-06-14
Filing date: 2016-06-14
Publication date: 2020-05-05
Anticipated expiration: 2036-06-14
Also published as: CN105902867A

Abstract

The invention discloses a bitter gourd plant medicine composition for reducing high blood pressure, high blood sugar and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The botanical drug composition is prepared from the following raw materials in parts by weight: balsam pear, tartary buckwheat, hawthorn, medlar, corn stigma, salvia miltiorrhiza, bighead atractylodes rhizome and liquorice. The 8 Chinese herbal medicines selected by the invention have the health care effects of cooling blood, removing toxicity, promoting digestion, invigorating stomach, calming liver, benefiting gallbladder, reducing blood sugar, dilating blood vessels and reducing blood viscosity under the combined action, and are very suitable for daily treatment, prevention and health care of hypertension, hyperglycemia and hyperlipidemia.

Description

A herbal composition for reducing hypertension, hyperglycemia and hyperlipidemia, and its preparation method

The technical field is as follows:

the invention relates to the technical field of traditional Chinese medicines, in particular to a herbal medicine composition for reducing high blood pressure, high blood sugar and high blood fat and a preparation method thereof.

Background

Three highs are the general terms of hyperlipidemia, hypertension and hyperglycemia, which are "rich diseases" derived from modern society, and may exist alone or be related to each other. Such as: diabetes patients are easy to suffer from hypertension or hyperlipidemia at the same time, the hyperlipidemia is also a main factor for the formation and development of arteriosclerosis, and the blood vessel elasticity of the arteriosclerosis patients is poor to aggravate the increase of blood pressure. Therefore, when any one of the three diseases appears, the "three-high disease" is easily formed in the later period. The cardiovascular and cerebrovascular diseases have the characteristics of high morbidity, high disability rate, high mortality rate, high recurrence rate and more complications, and the complications are more than four high and one high, and at present, the cardiovascular and cerebrovascular disease patients in China exceed 2.7 hundred million people! The world health organization has clearly proposed that the first line of defense in preventing cardiovascular disease is to reduce "three highs" and control "three highs".

The Western medicines are mainly used for treating the hypertension, the hyperlipidemia and the hyperglycemia, and although the Western medicines can control the hypertension, the hyperlipidemia and the hyperglycemia to a certain extent, adverse reactions sometimes occur while the three highs are effectively regulated by the Western medicines. In recent years, more and more people are willing to use natural plant medicines to treat 'three-high disease', and the plant medicines have definite curative effect on the three-high disease and high safety with small side effect.

The invention adopts the root, stem, leaf, flower, fruit and seed of pure natural plant medicine with excellent quality and low price to prepare extract by the processes of cleaning, drying, crushing, extracting, concentrating, mixing and the like under the aseptic and dustless conditions, and then spray-drying to obtain the mixed powder of the plant medicine composition, wherein the mixed powder of the plant medicine can be prepared into tablets, granules or capsules and the like, is convenient to take, has stable curative effect on treating hypertension, hyperglycemia and hyperlipidemia and has no toxic or side effect. The formula is prepared by refining 8 plant medicines, is mainly used for treating hypertension, hyperlipidemia, hyperglycemia and other three-high diseases, and can also be used for preventing the three-high diseases caused by various reasons.

Disclosure of Invention

The invention aims to provide a bitter gourd medicinal composition with the effects of reducing hyperlipidemia, hypertension and hyperglycemia.

The medicine composition of the invention contains 8 Chinese herbal medicines such as balsam pear, tartary buckwheat, hawthorn, medlar, corn stigma, salvia miltiorrhiza, bighead atractylodes rhizome, liquorice and the like, and the medicines are mutually compatible and act to jointly play the treatment and health care effects of cooling blood and detoxifying, promoting digestion and invigorating stomach, calming liver and benefiting gallbladder, reducing blood sugar, expanding blood vessels and reducing blood viscosity, thereby being very suitable for daily treatment, prevention and health care of three highs.

Specifically, the pharmaceutical composition is prepared from the following raw material medicines in parts by weight:

40-50 parts of bitter gourd, 40-50 parts of tartary buckwheat, 20-30 parts of hawthorn, 20-30 parts of medlar, 30-40 parts of corn stigma, 40-50 parts of salvia miltiorrhiza, 20-30 parts of bighead atractylodes rhizome and 20-30 parts of liquorice.

Further preferably, the pharmaceutical composition of the present invention is prepared from the following raw materials in parts by weight:

42-48 parts of bitter gourd, 42-48 parts of tartary buckwheat, 23-27 parts of hawthorn, 23-27 parts of medlar, 33-37 parts of corn stigma, 42-48 parts of salvia miltiorrhiza, 23-27 parts of bighead atractylodes rhizome and 23-27 parts of liquorice.

More preferably, the pharmaceutical composition of the present invention is prepared from the following raw materials by weight:

45 parts of balsam pear, 45 parts of tartary buckwheat, 25 parts of hawthorn, 25 parts of medlar, 35 parts of corn stigma, 45 parts of salvia miltiorrhiza, 25 parts of bighead atractylodes rhizome and 25 parts of liquorice.

The invention also aims to provide a preparation method of the bitter gourd medicinal composition.

The preparation method comprises the following steps:

(1) weighing 6 raw materials of hawthorn, medlar, corn stigma, salvia miltiorrhiza, liquorice and bighead atractylodes rhizome according to the proportion, crushing, extracting with 10 times of ethanol under reflux for 2-3 times, extracting for 3 hours each time, filtering, combining filtrates, cooling the filtrate to 30-50 ℃, concentrating to room temperature, measuring the relative density to be 1.05-1.20, and centrifuging to remove impurities for later use;

(2) oven drying fresh fructus Momordicae Charantiae, pulverizing into powder, reflux-extracting with 15-20 times of 90% ethanol at 70 deg.C in water bath for 2-3 times (each for 2-3 hr), filtering, cooling the filtrate concentrate to 25 deg.C, concentrating to room temperature, measuring relative density to 1.05-1.20, and centrifuging to remove impurities;

(3) reflux-extracting radix Et rhizoma Fagopyri Tatarici with 10-15 times of ethanol at 50 deg.C in water bath for 1-2 hr for 2-3 times, filtering, cooling filtrate concentrate to 25 deg.C, concentrating to room temperature to determine relative density of 1.05-1.20, and centrifuging to remove impurities;

(4) and (3) combining the concentrated solutions obtained in the step (1) and the steps (2) and (3), uniformly mixing, concentrating under reduced pressure to obtain an extract with the relative density of the liquid medicine of 1.15, and performing spray drying to obtain the botanical drug composition.

The invention also aims to provide the application of the pharmaceutical composition in preparing the medicines for cooling blood, removing toxicity, promoting digestion, invigorating stomach, calming liver, benefiting gallbladder, reducing blood sugar, dilating blood vessels and reducing blood viscosity.

The pharmaceutical composition of the present invention can be prepared into any pharmaceutically acceptable dosage forms, including: tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, hard capsules, soft capsules, oral liquids, buccal agents, granules, pills, powders, ointments, pellets, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, drops, patches. The formulations of the present invention, preferably oral dosage forms, are: capsule, tablet, oral liquid, granule, pill, powder, pellet, and unguent.

The administration route of the present invention may be oral, parenteral or topical, preferably oral and injectable. The oral administration preparation suitable for pharmaceutical use may be a tablet, capsule, granule or other liquid form preparation suitable for pharmaceutical use such as solution, emulsion, suspension, etc. Preferred oral formulations are tablets, and the tablets may be formulated as a coating, enteric, sustained release or metered release.

The pharmaceutical composition of the present invention, its preparation for oral administration, may contain conventional excipients such as binders, fillers, diluents, tabletting agents, lubricants, disintegrants, coloring agents, flavoring agents and wetting agents, and the tablet may be coated if necessary.

Suitable fillers include cellulose, mannitol, lactose and other similar fillers. Suitable disintegrants include starch, polyvinylpyrrolidone and starch derivatives, such as sodium starch glycolate. Suitable lubricants include, for example, magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate.

The solid oral compositions can be prepared by conventional methods of mixing, filling, tabletting and the like. Repeated mixing can distribute the active throughout those compositions that use large amounts of filler.

Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups or elixirs, or may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate or acacia; non-aqueous carriers (which may include edible oils), for example almond oil, fractionated coconut oil, oily esters such as esters of glycerol, propylene glycol or ethyl alcohol; preservatives, for example p-hydroxybenzyl or propyl p-hydroxybenzoate or sorbic acid, and, if desired, conventional flavouring or colouring agents.

For injections, liquid unit dosage forms are prepared containing the active substances of the invention and a sterile carrier. Depending on the carrier and concentration, the compound may be suspended or dissolved. Solutions are generally prepared by dissolving the active substance in a carrier, filter sterilising before filling it into a suitable vial or ampoule and then sealing. Adjuvants such as a local anaesthetic, preservatives and buffering agents may also be dissolved in the vehicle. To improve its stability, the composition can be frozen after filling into vials and the water removed under vacuum.

The pharmaceutical composition can be selectively added with a suitable pharmaceutically acceptable carrier when being prepared into a medicament, wherein the pharmaceutically acceptable carrier is selected from mannitol, sorbitol, sodium metabisulfite, sodium bisulfite, sodium thiosulfate, cysteine hydrochloride, thioglycolic acid, methionine, vitamin C, EDTA disodium, EDTA calcium sodium, carbonate, acetate, phosphate or aqueous solution thereof of monovalent alkali metals, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and derivatives thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, a surfactant, polyethylene glycol, cyclodextrin, β -cyclodextrin, phospholipid materials, kaolin, talcum powder, calcium stearate, magnesium stearate and the like.

The compounds of the present invention or pharmaceutically acceptable salts thereof may be administered alone or in the form of pharmaceutical compositions. The pharmaceutical composition of the present invention can be formulated into various suitable dosage forms according to the administration route. The use of one or more physiologically acceptable carriers, including excipients and auxiliaries, facilitates processing of the active compounds into preparations which can be used pharmaceutically. The appropriate formulation will depend on the route of administration chosen and may be prepared in accordance with common general knowledge in the art.

In the pharmaceutical composition of the invention, the effects of the components are as follows:

the balsam pear can be used as both medicine and food, and has high medicinal value, and the ancient Chinese medical scientist Li Shizhen says that: bitter gourd, cold in taste and non-toxic, can reduce pathogenic heat, relieve fatigue, clear heart fire and improve eyesight, replenish qi and strengthen yang. The balsam pear has the functions of strengthening spleen and stimulating appetite, clearing away heat and removing summer heat, improving eyesight and relieving dysentery, and cooling blood and removing toxicity. In recent years, scientists in the united states have found that momordica charantia contains certain physiologically active proteins, and injection of such proteins into animals drives immune cells of the animals to destroy cancer cells. Chinese scientists also separate insulin 23 from balsam pear, which has obvious hypoglycemic effect and is an ideal food for diabetics.

Tartary buckwheat is a dual-purpose plant for medicine and food, and is recorded in Ben Cao gang mu: the tartary buckwheat is bitter in taste and neutral in nature and cold in nature, can strengthen intestines and stomach, tonify qi, continue spirit, benefit ears and eyes, refine dirt in five internal organs and residues, and has the effects of soothing nerves, promoting blood circulation, descending qi, widening intestines, clearing heat, removing stasis, relaxing bowel, relieving cough and asthma, resisting inflammation, resisting allergy, strengthening heart, losing weight, beautifying and the like.

The hawthorn is a medicine and food dual-purpose crop, and is recorded in Ben Cao gang mu: the hawthorn is sour and sweet in taste and slightly warm in nature, enters the lung channel of Taiyin and the liver channel of foot jueyin, and has the effects of relieving dyspepsia, dispelling blood stasis, expelling tapeworm, promoting digestion, invigorating stomach, promoting qi circulation and removing blood stasis. Can be used for treating dyspepsia, flatulence, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, heart and abdominal pain, hernia pain, and hyperlipidemia.

Wolfberry fruit: is a dual-purpose plant for medicine and food, has sweet and mild nature and flavor, and enters liver, kidney and lung meridians. Has effects in invigorating kidney, replenishing vital essence, nourishing liver, improving eyesight, moistening lung, and nourishing yin. Sweet, neutral and moist, nourishing liver and kidney, and tonifying and strengthening action, it is indicated for all syndromes of yin deficiency of liver and kidney. Treating: dizziness, vertigo and hypopsia due to deficiency of liver and kidney, and essence and blood; soreness and weakness of waist and knees, spermatorrhea, and diabetes due to yin deficiency of liver and kidney.

Corn silk: neutral in nature, sweet and bland in flavor, entering liver, kidney and bladder meridians. Has effects of inducing diuresis to alleviate edema, calming liver and promoting bile flow. The traditional Chinese medicine considers that in the traditional Chinese medicine, the corn stigma is also called as the dragon whiskers and has wide prevention and health care effects. Has good health promotion effect for people with hyperlipemia, hypertension and hyperglycemia, and can reduce blood lipid, blood pressure and blood sugar, remove damp-heat in vivo, and induce diuresis to alleviate edema.

Red sage root: bitter in taste and slightly cold in nature. Enter heart and liver meridians. Has effects in promoting blood circulation, dispelling blood stasis, relieving swelling, stopping bleeding, relieving inflammation and pain, regulating menstruation, and relieving pain, and can be used for dilating coronary artery, improving myocardial ischemia, and lowering blood pressure. So it is said that "Dan Shen, one herb has the same action as four herbs". Recent medical experiments prove that the salvia miltiorrhiza also has the functions of resisting platelet aggregation, reducing blood viscosity and regulating an internal and external blood coagulation system, and is a safe and reliable natural traditional Chinese medicine for treating cardiovascular diseases.

White atractylodes rhizome: bitter and sweet in taste and warm in nature. Enter spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. It is commonly used for weakness of spleen and stomach: poor appetite, asthenia, loose stool, mental fatigue and hypodynamia; deficiency-cold of the spleen and stomach, abdominal cold pain, stool diarrhea; spleen deficiency, dampness stagnation, diarrhea and loose stool; phlegm-fluid retention, edema and dysuria due to spleen deficiency and water retention.

Licorice root: neutral in nature and sweet in taste, has the functions of tonifying spleen and stomach, moistening lung and arresting cough, clearing heat and removing toxicity, harmonizing the other drugs, purging pathogenic fire when used unprocessed and warming the middle warmer when prepared. The traditional Chinese medicine has a plurality of functions of liquorice inside the traditional Chinese medicine, and has the functions of clearing away heat and toxic materials, treating stranguria and promoting urination besides tonifying qi and spleen. Licorice root, radix Glycyrrhizae can relieve spasm and harmonize the herbs.

The invention adopts the principle of homology of medicine and food, various plants with homology of medicine and food are selected according to the formula, beneficial chemical components in the plants are extracted to the maximum extent through a reasonable extraction process, and the effective components are reasonably matched by the theory of traditional Chinese medicine, so that the combination effect of the components in the aspect of reducing hypertension, hyperglycemia and hyperlipidemia is exerted to the maximum extent, and the good treatment effect of hypertension, hyperlipidemia and hyperglycemia can be achieved, and the positive prevention effect of hypertension, hyperlipidemia and hyperglycemia can be achieved. Has the health care effects of cooling blood, removing toxic substances, promoting digestion, invigorating stomach, calming liver, benefiting gallbladder, reducing blood sugar, expanding blood vessels and reducing blood viscosity, and is very suitable for treatment, prevention and health care of three highs by daily taking.

Compared with the existing product, the invention has the following beneficial effects:

compared with the conventional antihypertensive drug, the herbal composition has the unique characteristics that: starting from two aspects of diseases and pathogenesis sources of hypertension, hyperlipidemia, hyperglycemia and the like, on one hand, the traditional Chinese medicine aims at treating symptoms of three-high disease clinical indexes, and on the other hand, the effect of combining a plurality of medicines is comprehensively adjusted for a human body, so that the effects of cooling blood and detoxifying, helping digestion and invigorating stomach, calming the liver and benefiting gallbladder, reducing blood sugar, expanding blood vessels, reducing blood viscosity and the like are achieved, and the aim of treating the root causes is achieved.

Secondly, the raw materials in the formula mainly adopt medicinal and edible plant medicines, such as bitter gourd, tartary buckwheat, hawthorn, medlar and the like, which are medicinal and edible plants, and the composition can be used for preventing and treating hypertension, hyperglycemia and hyperlipidemia, removing intravascular garbage, enhancing cell activity, achieving the purpose of health preservation and health care by frequent administration, and accords with the health preservation concept of 'green and healthy'.

Thirdly, the composition is convenient to select oral administration preparations, the oral administration preparations are convenient, the composition can be quickly decomposed and absorbed after being administered, redundant harmful substances in blood vessels can be effectively removed while blood sugar is reduced, blood vessels are dilated, the blood viscosity is reduced, and although the cause of hypertension is complex, the increase of the harmful substances in the blood vessels can cause the rise of the blood vessel pressure and the reduction of the elasticity, so that the disease cause of the hypertension can be fundamentally restrained through the quick release of the composition after the oral administration, and the purpose of treatment is achieved.

And fourthly, the prescription is novel, the process is unique, the complexity is simplified, the balance of the drug efficacy and the moderation of the action are emphasized, and the aim of overall effect is achieved. The bitter gourd, the tartary buckwheat, the hawthorn, the medlar, the corn stigma, the salvia miltiorrhiza, the liquorice and the bighead atractylodes rhizome are selected from 8 medicines of the bitter gourd, the tartary buckwheat, the hawthorn, the medlar and the salvia miltiorrhiza, the tartary buckwheat, the hawthorn and the medlar which have homology of medicine and food and four medicines of the salvia miltiorrhiza, the corn stigma, the liquorice, the bighead atractylodes rhizome, the hawthorn and the medlar which have definite curative effect and mild effect, wherein the salvia miltiorrhiza, the corn stigma, the liquorice, the bighead atractylodes rhizome, the hawthorn and the medlar are extracted together, and then are mixed with the bitter gourd and tartary buckwheat extracts which are extracted.

The pathogenesis of hypertension is more complex, various medicines have different functions in vivo, and the effect is not ideal when the medicine is used alone. Therefore, in order to achieve the purpose of overall treatment, a reasonable formula is combined with a modern extraction process, the effect of each medicine is exerted to the maximum, the overall prescription is novel, and a reasonable extraction method is selected according to the characteristics of the medicines, so that the composition has good treatment and prevention effects on the hypertension, hyperlipidemia and hyperglycemia.

Detailed Description

The present invention is further described in detail by the following specific examples and experiments.

Preparation examples

Example 1 pharmaceutical compositions of the invention

A bitter gourd plant medicine composition for reducing hypertension, hyperglycemia and hyperlipidemia is prepared from the following raw material medicines in parts by weight: 40-50 parts of bitter gourd, 40-50 parts of tartary buckwheat, 20-30 parts of hawthorn, 20-30 parts of medlar, 30-40 parts of corn stigma, 40-50 parts of salvia miltiorrhiza, 20-30 parts of bighead atractylodes rhizome and 20-30 parts of liquorice.

The preparation method of the bitter gourd plant medicine composition for reducing the three highs comprises the following steps:

(1) weighing 6 raw materials of hawthorn, medlar, corn stigma, salvia miltiorrhiza, liquorice and bighead atractylodes rhizome according to the proportion, crushing, extracting for 2-3 times by 10 times of ethanol in a refluxing way, extracting for 3 hours each time, filtering, combining filtrates, cooling the filtrates to 30-50 ℃, concentrating until the relative density is 1.05-1.20 at room temperature, and centrifuging to remove impurities for later use.

(2) Oven drying fresh fructus Momordicae Charantiae, pulverizing into powder, reflux-extracting with 15-20 times of 90% ethanol at 70 deg.C in water bath for 2-3 times (each for 2-3 hr), filtering, cooling the filtrate concentrate to 25 deg.C, concentrating to room temperature, measuring relative density to 1.05-1.20, and centrifuging to remove impurities.

(3) Reflux-extracting radix Et rhizoma Fagopyri Tatarici with 10-15 times of ethanol at 50 deg.C in water bath for 1-2 hr for 2-3 times, filtering, cooling filtrate concentrate to 25 deg.C, concentrating to room temperature to determine relative density of 1.05-1.20, and centrifuging to remove impurities.

The above herbal composition can be combined with pharmaceutically acceptable carrier to make into preparation. The preparation is tablets, granules or capsules.

Example 2 pharmaceutical compositions of the invention

A bitter gourd plant medicine composition for reducing hypertension, hyperglycemia and hyperlipidemia is prepared from the following raw material medicines in parts by weight: 42-48 parts of bitter gourd, 42-48 parts of tartary buckwheat, 23-27 parts of hawthorn, 23-27 parts of medlar, 33-37 parts of corn stigma, 42-48 parts of salvia miltiorrhiza, 23-27 parts of bighead atractylodes rhizome and 23-27 parts of liquorice.

Example 3 pharmaceutical compositions of the invention

A bitter gourd plant medicine composition for reducing hypertension, hyperglycemia and hyperlipidemia is prepared from the following raw material medicines in parts by weight: 45 parts of balsam pear, 45 parts of tartary buckwheat, 25 parts of hawthorn, 25 parts of medlar, 35 parts of corn stigma, 45 parts of salvia miltiorrhiza, 25 parts of bighead atractylodes rhizome and 25 parts of liquorice.

Animal experiments

Experimental examples 1,

Male Wistar rats, weighing 210 ± 20g, were randomized 15 days after acclimation of experimental animals into 3 groups by weight: the blank control group was given standard rat diet, and the model group and treatment group were given high fat, high sugar,Feeding with high-salt feed, feeding and drinking water freely, and feeding with gastric lavage, wherein the blank control group and model group are fed with distilled water 10 mL/kg. d^-1The treatment group is administered with 10 mL/kg. d of the liquid medicine^-1(equivalent to 0.20 g/kg. d) of fluid extract), and the feed was maintained for 10 weeks in each group. The drug selected for the treatment group was the drug prepared in example 3.

Results of the experiment

Fasting plasma glucose, serum insulin, glycated hemoglobin level changes

The results show that: the Fasting Blood Glucose (FBG) and the glycosylated hemoglobin (HbA1c) of the rats in the model group are obviously increased, compared with the normal group, the difference is very obvious (P is less than 0.05), the treatment group is greatly reduced compared with the model group, the difference is very obvious (P is less than 0.05) in the two groups, but the result is still higher than that in the normal group. The insulin level of the model group is obviously reduced (P is less than 0.05) compared with that of the normal group, the insulin level of the treatment group is also obviously reduced, but the difference is obvious (P is less than 0.05) compared with the model group, which shows that the traditional Chinese medicine composition has good effects of reducing blood sugar, reducing non-enzymatic glycosylation of protein and regulating the insulin level shown in the table 1.

TABLE 1 comparison of fasting FBG, fasting Ins, fasting HbA1c levels (x. + -. s)

Group of	N	FBG(mmol/L)	Ins(uIU/mL)	HbA1c(％)
					Blank group	10	5.41±0.44	95.24±37.26	4.42±0.52
Model set	12	22.34±4.29	38.69±13.27	8.97±2.13
					Treatment group	12	11.23±5.21	72.08±18.30	7.35±1.25

Note: model group to normal group comparison: p is less than 0.05, and P is less than 0.05 compared with the model group

Changes in blood lipids

The results show that: the rats in the model group have serious lipid metabolism disorder, TG, TCH and LDL-C levels are increased, HDL-C levels are obviously reduced, the difference is obvious (P is less than 0.05) compared with that in the normal group, after the rats are treated by the traditional Chinese medicine composition, all indexes of TG, TCH and LDL-C, HDL-C are improved, the TG, TCH and LDL-C levels are reduced, and HDL-C levels are increased (P is less than 0.05), so that the traditional Chinese medicine composition has an obvious effect of regulating lipid metabolism, and the results are shown in Table 2.

TABLE 2 comparison of TG, TCH, LDL-C, HDL-C levels (x. + -. s) for each group

The experimental study shows that: the composition has effects of reducing blood sugar and blood lipid, and regulating "three highs".

Claims

1. A bitter gourd medicinal composition with the effects of reducing hyperlipidemia, hypertension and hyperglycemia is prepared from the following raw material medicines in parts by weight:

42-48 parts of balsam pear, 42-48 parts of tartary buckwheat, 23-27 parts of hawthorn, 23-27 parts of medlar, 33-37 parts of corn stigma, 42-48 parts of salvia miltiorrhiza, 23-27 parts of bighead atractylodes rhizome and 23-27 parts of liquorice,

the preparation method comprises the following steps:

2. The pharmaceutical composition according to claim 1, which is prepared from the following raw materials in parts by weight:

3. The pharmaceutical composition of claim 1, capable of being prepared in any pharmaceutically acceptable dosage form, comprising: tablet, capsule, oral liquid, buccal agent, granule, pill, powder, unguent, pellet, suspension, powder, solution, injection, suppository, cream, spray, drop, and patch.

4. The pharmaceutical composition of claim 3, characterized in that: the dosage form is tablets, granules or capsules.

5. The pharmaceutical composition of claim 1, optionally comprising a suitable pharmaceutically acceptable carrier when formulated into a medicament, said pharmaceutically acceptable carrier selected from the group consisting of: mannitol, sorbitol, sodium metabisulfite, sodium bisulfite, sodium thiosulfate, cysteine hydrochloride, thioglycolic acid, methionine, vitamin C, EDTA disodium, calcium sodium EDTA, monovalent alkali metal carbonates, acetates, phosphates or aqueous solutions thereof, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acids, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and derivatives thereof, alginates, gelatin, polyvinylpyrrolidone, glycerol, agar-agar, calcium carbonate, calcium bicarbonate, surfactants, polyethylene glycol, cyclodextrin, phospholipid materials, kaolin, talc, calcium stearate, magnesium stearate.

6. The use of the pharmaceutical composition of claim 1 in the preparation of a medicament for cooling blood, removing toxic substances, promoting digestion, calming the liver, promoting bile flow, lowering blood glucose, dilating blood vessels, and lowering blood viscosity.