CN110694013A - Pressed candy for relieving alopecia and preparation process thereof - Google Patents

Pressed candy for relieving alopecia and preparation process thereof Download PDF

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CN110694013A
CN110694013A CN201910918880.3A CN201910918880A CN110694013A CN 110694013 A CN110694013 A CN 110694013A CN 201910918880 A CN201910918880 A CN 201910918880A CN 110694013 A CN110694013 A CN 110694013A
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candy
filtrate
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王明谦
纪东艺
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Ningbo Dekang Biological Products Co Ltd
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Ningbo Dekang Biological Products Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
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    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia

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Abstract

The invention belongs to the technical field of medicinal and edible traditional Chinese medicinal materials, and particularly relates to a tablet candy for relieving alopecia and a preparation process thereof. The tablet candy comprises the following traditional Chinese medicine raw materials in percentage by weight: 10-30% of black sesame, 10-30% of black bean, 5-15% of medlar, 5-15% of hawthorn, 5-15% of tuckahoe, 5-15% of coix seed, 5-10% of rhizoma polygonati, 5-10% of mulberry leaf, 5-10% of kudzu root, 5-10% of liquorice and 2-5% of donkey-hide gelatin; the raw material components mainly nourish liver and kidney, replenish essence and blood, supplement qi and blood, promote diuresis and eliminate dampness, and improve alopecia symptoms from multiple angles; the preparation process is simple, and the obtained tabletted candy can be stored for a long time, is convenient to carry, has no toxic or side effect, and is convenient for batch production.

Description

Pressed candy for relieving alopecia and preparation process thereof
Technical Field
The invention belongs to the technical field of medicinal and edible traditional Chinese medicinal materials, and particularly relates to a pressed candy for relieving alopecia and promoting hair growth and a preparation process thereof.
Background
Alopecia is the phenomenon of hair loss, and is divided into physiological and pathological. Physiological alopecia refers to the normal shedding of hair. Pathologic hair loss refers to abnormal or excessive hair loss. With the increasing social pressure, the accelerating life rhythm, the continuous deterioration of the environment and the poor dietary habits, the base number of unhealthy and sub-healthy people is increased day by day, the incidence rate of alopecia is higher and the incidence population tends to be younger.
The main causes of hair loss at present are attributed to: genetic factors, deficiency or dysregulation of male hormones in the blood circulation; being too obese; scars left by various skin diseases or skin injuries; natural hair dysplasia; the use of chemicals or physical causes severe damage to hair follicles. In order to quickly relieve the trouble caused by alopecia, people often select western medicines with quick curative effect for treatment, but the western medicines have large toxic and side effects, single treatment target and easy relapse of the disease, and mostly treat the symptoms but not the root cause.
The Chinese medicine attracts more and more attention for the purposes of treating diseases and seeking resources and treating diseases and saving basis. According to different understanding on alopecia mechanisms, the Chinese medicine has the common self-help that the main reason is kidney essence deficiency, lung qi deficiency, kidney yin deficiency, spleen dysfunction, liver and kidney deficiency and the like. Therefore, in combination with the above practical problems, there is a need to develop a Chinese medicinal material product which has the effects of nourishing liver and kidney, replenishing essence and blood, nourishing qi and blood, promoting diuresis and excreting dampness as auxiliary materials and can improve the symptoms of different alopecia patients by cutting into the Chinese medicinal material product from multiple angles. The functional tabletting candy prepared by taking traditional Chinese medicines as raw materials can promote human health and regulate specific physiological functions of human bodies, does not produce adverse reactions to human bodies, is more and more popular with people, has the characteristics of nutrition and sensory enjoyment of common foods like common candies, and can regulate physiological functions of human bodies, promote human health, break through sub-health, prevent diseases and the like. In order to solve the practical problems and meet the requirements of people, the pressed candy for relieving alopecia, which takes medicinal and edible traditional Chinese medicinal materials as raw materials, is produced at present.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a tablet candy taking medicinal and edible traditional Chinese medicinal materials as raw material components, which is mainly used for nourishing liver and kidney and benefiting essence and blood, is assisted by nourishing qi and blood and promoting diuresis and excreting dampness, improves alopecia symptoms from multiple angles and has no toxic or side effect.
The purpose of the invention can be realized by the following technical scheme: a tablet candy for relieving alopecia comprises the following traditional Chinese medicine raw materials in percentage by weight: 10-30% of black sesame, 10-30% of black bean, 5-15% of medlar, 5-15% of hawthorn, 5-15% of tuckahoe, 5-15% of coix seed, 5-10% of rhizoma polygonati, 5-10% of mulberry leaf, 5-10% of kudzu root, 5-10% of liquorice and 2-5% of donkey-hide gelatin.
Preferably, the tablet candy comprises the following traditional Chinese medicine raw materials in percentage by weight: 12-25% of black sesame, 15-22% of black bean, 6-12% of medlar, 5-10% of hawthorn, 8-15% of tuckahoe, 6-12% of coix seed, 5-8% of rhizoma polygonati, 6-8% of mulberry leaf, 5-8% of kudzu root, 5-8% of liquorice and 2-4% of donkey-hide gelatin.
Further preferably, the tablet candy comprises the following traditional Chinese medicine raw materials in percentage by weight: 18% of black sesame, 18% of black bean, 9% of medlar, 7% of hawthorn, 10% of tuckahoe, 8% of coix seed, 7% of rhizoma polygonati, 7% of mulberry leaf, 6% of kudzu root, 7% of liquorice and 3% of donkey-hide gelatin.
According to the compendium of materia medica and the record of the pharmacopoeia of traditional Chinese medicine, the substitute tea of the invention has the following functional effects:
black sesame seed: tonify liver and kidney, nourish essence and blood, moisten intestine and dry. Can be used for treating deficiency of essence and blood, dizziness, dim eyesight, tinnitus, deafness, premature gray hair, alopecia after illness, and constipation due to intestinal dryness.
Black bean: to replenish vital essence, improve eyesight, nourish blood, dispel wind, induce diuresis, and remove toxicity. Can be used for treating yin deficiency, polydipsia, dizziness, blurred vision, asthenia, hyperhidrosis, lumbago due to kidney deficiency, edema, oliguria, arthralgia, spasm, numbness of limbs, and poisoning due to medicine and food.
Medlar: nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating consumptive disease and essence deficiency, soreness of waist and knees, giddiness and tinnitus, sexual impotence and nocturnal emission, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.
Hawthorn fruit: promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid. Can be used for treating meat retention, gastralgia, abdominal pain due to dysentery, amenorrhea due to blood stasis, puerperal blood stasis, cardialgia, thoracic obstruction, cardialgia, hernia pain, and high lipidemia.
Tuckahoe, poria cocos: induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Coix seed: induce diuresis and drain dampness, invigorate spleen to arrest diarrhea, remove arthralgia, expel pus, remove toxicity and dissipate nodulation. Can be used for treating edema, loempe, dysuria, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, intestinal abscess, wart, and cancer.
Rhizoma polygonati: tonify qi and yin, invigorate spleen, moisten lung and tonify kidney. Can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, cough with little appetite, lung deficiency, cough with excessive consumption, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat with thirst quenching effect.
Mulberry leaf: disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight.
Kudzu root: expelling pathogenic factors from muscles and skin, relieving fever, promoting salivation, quenching thirst, promoting eruption, invigorating yang, relieving diarrhea, dredging meridian passage, and relieving alcoholism. Can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery due to heat evil, diarrhea, vertigo, headache, apoplexy, hemiplegia, thoracic obstruction, cardiodynia, and alcoholic injury.
Licorice root: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the other drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
E, donkey-hide gelatin: tonify blood, nourish yin, moisten dryness and stop bleeding. Can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, muscle weakness, vexation, insomnia, deficient wind stirring, cough due to dryness of lung, overstrain cough, hemoptysis, hematemesis, hematuria, hematochezia, metrorrhagia, and gestational fetal leakage.
The black sesame and the black bean are used as main raw materials, the black sesame and the black bean are used for synergistically tonifying liver and kidney and replenishing essence and blood, and the medlar, the tuckahoe, the coix seed and other raw material components are used as auxiliary raw materials for nourishing qi and blood, promoting diuresis and excreting dampness; the main and auxiliary phases are combined, and the aim of improving alopecia symptoms from multiple angles is fulfilled.
The invention also aims to provide a preparation process of the tabletting candy, which comprises the following steps:
(1) weighing the raw materials according to the weight percentage for later use;
(2) mixing the raw materials in the step (1), adding 8-10 times of water by weight, heating to boil, keeping slight boiling for 1-2 hours, and passing through a 250-350-mesh sieve while the mixture is hot to obtain a filtrate 1;
(3) adding water with the weight 5-8 times that of the residue sieved in the step (2) into the residue, heating the residue to boil, keeping the residue slightly boiling for 1-2 hours, and passing the residue through a 250-350-mesh sieve while the residue is hot to obtain a filtrate 2;
(4) mixing the filtrate 1 and the filtrate 2, concentrating and drying to obtain a powder semi-finished product;
(5) mixing the powder semi-finished product with food additive, and tabletting to obtain candy finished product.
In the preparation process, the raw materials are heated, boiled and slightly boiled, so that the effective components in the raw materials can be dissolved out to the maximum extent, and the raw materials are repeatedly extracted and filtered, so that the loss of the effective components in the raw materials and the waste of resources are reduced. The tabletted candy prepared by the invention has long storage life and is convenient to carry, and the preparation process is simple and is convenient for batch production.
The specification of the tabletted candies of the present invention includes, but is not limited to, 0.5 g/tablet, 1 g/tablet, and the filling amount includes, but is not limited to, 50 g/bottle, 100 g/bottle. The dosage can be increased or decreased according to body constitution and individual symptoms.
Preferably, the concentration and drying in the step (4) comprises the following specific processes: concentrating the combined filtrate under the conditions of vacuum degree of-0.08 to-0.1 MPa and temperature of 70 to 80 ℃, and then spray-drying the concentrated solution at the temperature of 140 to 160 ℃. The concentration and drying process has the advantages of high speed and short time, can effectively reduce the adhesion among the raw materials, and improves the powder yield and the powder quality.
Preferably, the food additive in the step (5) is a mixture of xylitol and magnesium stearate, wherein the xylitol accounts for 2-5% of the total amount of the semi-finished product powder, and the magnesium stearate accounts for 0.5-1.5% of the total amount of the semi-finished product powder. The two food additives are added in the preparation process of the invention to be blended with the traditional Chinese medicine components, so that the storage life of the pressed product can be prolonged, and the comfortable taste of the product can be maintained.
Compared with the prior art, the invention has the following advantages:
1. according to the invention, through reasonable compatibility of medicinal and edible traditional Chinese medicinal materials, black sesame and black bean are used as main raw materials, the black sesame and the black bean are used for synergistically nourishing liver and kidney and benefiting essence and blood, and medlar, tuckahoe, coix seeds and other raw material components are used for assisting in nourishing qi and blood, promoting diuresis and excreting dampness; the main and the auxiliary are combined, thus achieving the purpose of improving the symptoms of alopecia from multiple angles.
2. The tabletted candy prepared by the invention has the advantages of long storage life, portability, no toxic or side effect, simple process and convenience for batch production.
Detailed Description
The following are specific examples of the present invention and illustrate the technical solutions of the present invention for further description, but the present invention is not limited to these examples. The raw materials used in the examples of the present invention are those commonly used in the art, and the methods used in the examples are those conventional in the art, unless otherwise specified.
Example 1
Weighing 10g of black sesame, 10g of black beans, 5g of medlar, 15g of hawthorn, 15g of poria cocos, 6g of coix seeds, 7g of rhizoma polygonati, 10g of mulberry leaves, 10g of kudzu roots, 10g of liquorice and 2g of donkey-hide gelatin;
mixing the above raw materials, adding 8 times of water, heating to boil, keeping slightly boiling for 1 hr, and hot sieving with 250 mesh sieve to obtain filtrate 1;
adding 5 times of water by weight into the sieved residual dregs, heating to boil, keeping slightly boiling for 1 hour, and sieving with a 250-mesh sieve while the dregs are hot to obtain a filtrate 2;
mixing the filtrate 1 and the filtrate 2, concentrating and drying, concentrating under vacuum degree of-0.08 MPa and temperature of 70 deg.C, and spray drying the concentrated solution at 140 deg.C to obtain powder semi-finished product;
and uniformly mixing the powder semi-finished product with xylitol accounting for 2 percent of the total amount of the semi-finished product powder and magnesium stearate accounting for 0.5 percent of the total amount of the semi-finished product powder, and tabletting to obtain a finished candy product.
Example 2
Weighing 18g of black sesame, 18g of black bean, 9g of medlar, 7g of hawthorn, 10g of tuckahoe, 8g of coix seed, 7g of rhizoma polygonati, 7g of mulberry leaf, 6g of kudzuvine root, 7g of liquorice and 3g of donkey-hide gelatin;
mixing the above raw materials, adding 8 times of water, heating to boil, keeping slightly boiling for 1 hr, and hot sieving with 300 mesh sieve to obtain filtrate 1;
adding 6 times of water into the sieved residual dregs, heating to boil, keeping slightly boiling for 1.5 hours, and sieving with a 300-mesh sieve while the dregs are hot to obtain a filtrate 2;
mixing the filtrate 1 and the filtrate 2, concentrating and drying, concentrating under vacuum degree of-0.08 MPa and temperature of 70 deg.C, and spray drying the concentrated solution at 140 deg.C to obtain powder semi-finished product;
and uniformly mixing the powder semi-finished product with xylitol accounting for 3 percent of the total amount of the semi-finished product powder and magnesium stearate accounting for 0.8 percent of the total amount of the semi-finished product powder, and tabletting to obtain a finished candy product.
Example 3
Weighing 18g of black sesame, 18g of black beans, 9g of medlar, 7g of hawthorn, 10g of poria cocos, 8g of coix seeds, 7g of rhizoma polygonati, 7g of folium mori, 6g of radix puerariae, 7g of liquorice and 3g of donkey-hide gelatin;
mixing the raw materials, adding 9 times of water, heating to boil, keeping slightly boiling for 2 hours, and sieving with a 300-mesh sieve while the mixture is hot to obtain a filtrate 1;
adding 7 times of water by weight into the sieved residual dregs, heating to boil, keeping slightly boiling for 1.5 hours, and sieving with a 300-mesh sieve while the dregs are hot to obtain a filtrate 2;
mixing the filtrate 1 and the filtrate 2, concentrating and drying, concentrating under vacuum degree of-0.09 MPa and temperature of 75 deg.C, and spray drying the concentrated solution at 150 deg.C to obtain powder semi-finished product;
and uniformly mixing the powder semi-finished product with xylitol accounting for 3.5 percent of the total amount of the semi-finished product powder and magnesium stearate accounting for 1 percent of the total amount of the semi-finished product powder, and tabletting to obtain a finished candy product.
Example 4
Weighing 13g of black sesame, 15g of black beans, 15g of medlar, 12g of hawthorn, 10g of poria cocos, 10g of coix seeds, 5g of rhizoma polygonati, 5g of mulberry leaves, 5g of kudzu roots, 5g of liquorice and 5g of donkey-hide gelatin;
mixing the raw materials, adding 9 times of water, heating to boil, keeping slightly boiling for 2 hours, and sieving with a 300-mesh sieve while the mixture is hot to obtain a filtrate 1;
adding 7 times of water by weight into the sieved residual dregs, heating to boil, keeping slightly boiling for 1.5 hours, and sieving with a 300-mesh sieve while the dregs are hot to obtain a filtrate 2;
mixing the filtrate 1 and the filtrate 2, concentrating and drying, concentrating under vacuum degree of-0.09 MPa and temperature of 75 deg.C, and spray drying the concentrated solution at 150 deg.C to obtain powder semi-finished product;
and uniformly mixing the powder semi-finished product with xylitol accounting for 3.5 percent of the total amount of the semi-finished product powder and magnesium stearate accounting for 1 percent of the total amount of the semi-finished product powder, and tabletting to obtain a finished candy product.
Example 5
Weighing 26g of black sesame, 26g of black beans, 5g of medlar, 5g of hawthorn, 5g of poria cocos, 5g of coix seeds, 5g of rhizoma polygonati, 5g of mulberry leaves, 7g of kudzu roots, 7g of liquorice and 4g of donkey-hide gelatin;
mixing the raw materials, adding 10 times of water by weight, heating to boil, keeping slightly boiling for 2 hours, and sieving with a 350-mesh sieve while the mixture is hot to obtain a filtrate 1;
adding 8 times of water into the sieved residual dregs, heating to boil, keeping slightly boiling for 2 hours, and sieving with a 350-mesh sieve while the dregs are hot to obtain a filtrate 2;
mixing the filtrate 1 and the filtrate 2, concentrating and drying, concentrating under vacuum degree of-0.1 MPa and temperature of 80 deg.C, and spray drying the concentrated solution at 160 deg.C to obtain powder semi-finished product;
and uniformly mixing the powder semi-finished product with xylitol accounting for 5 percent of the total amount of the semi-finished product powder and magnesium stearate accounting for 1.5 percent of the total amount of the semi-finished product powder, and tabletting to obtain a finished candy product.
Comparative example 1
The comparative example is different from example 3 only in that the raw material is only 100g of black sesame, and the preparation process is the same as example 3.
Comparative example 2
The comparative example is different from example 3 only in that the raw material is 100g of black beans and the preparation process is the same as example 3.
Comparative example 3
The difference between the comparative example and the example 3 is that the raw materials comprise 36g of black sesame, 9g of medlar, 7g of hawthorn, 10g of tuckahoe, 8g of coix seed, 7g of rhizoma polygonati, 7g of mulberry leaf, 6g of kudzu root, 7g of liquorice and 3g of donkey-hide gelatin; the procedure was as in example 3.
Comparative example 4
The difference between the comparative example and the example 3 is that the raw materials comprise 36g of black beans, 9g of medlar, 7g of hawthorn, 10g of tuckahoe, 8g of coix seeds, 7g of rhizoma polygonati, 7g of mulberry leaves, 6g of kudzu roots, 7g of liquorice and 3g of donkey-hide gelatin; the procedure was as in example 3.
Comparative example 5
The difference between the comparative example and the example 3 is only that the raw materials comprise 18g of black sesame, 18g of black beans, 7g of medlar, 8g of coix seeds, 13g of hawthorn, 7g of rhizoma polygonati, 7g of mulberry leaves, 6g of kudzu roots, 7g of liquorice and 3g of donkey-hide gelatin; the procedure was as in example 3.
Comparative example 6
This comparative example differs from example 3 only in that the filtrates were combined and dried directly in an oven to give a powder without concentration during the preparation.
Clinical observations 1
The different states of the male and female physiological structures show that the male pattern alopecia is mainly characterized in that the hair on the front head and the top of the head, the hair line and the temples on the forehead move upwards, the hair on the front head and the top is sparse, yellow and soft, and finally the top of the forehead is bald or has a certain amount of hair; female hair loss is at the top of the head, and the hair becomes thin but does not fall off completely in pieces. In order to make the clinical data more accurate, the alopecia population is selected according to gender in the clinical test.
1. Clinical cases: the patients are 400 female patients and 400 male patients in total, wherein the cases are from different professional groups, wherein the male and female patients are 121 in 1 year, 192 in 1-3 years and 87 in more than 3 years.
2. The eating method comprises the following steps: the tablet candy of the embodiment 3 of the invention is eaten, the specification is 0.75 g/tablet, the loading capacity is 75 g/bottle, and the dosage can be increased or reduced according to the physique and personal symptoms.
3. The therapeutic effect judgment standard is as follows: the effect is shown: the hair loss phenomenon basically disappears, and new hair grows out; the method has the following advantages: the hair loss quantity is reduced; and (4) invalidation: the symptoms of hair loss are substantially unchanged. The observation period is 4 months, and if the effect is shown within 4 months, the administration is stopped; if the symptoms did not improve after 4 months, it was judged to be ineffective.
4. Therapeutic effects
The effective rate of the tablet candy can reach more than 94% in alopecia people, and the alopecia and hair loss phenomenon of more than 8 patients taking the tablet candy in more than 1 bottle is obviously improved. The results of the clinical data are shown in table 1.
Table 1: clinical data of patients with alopecia after using the candy tablets of the product example 3
Exemplary cases (these cases are actually used and achieve better using effect by the invention)
Patient 1:
a certain hair (Ningbo, female, 29 years old) is sparse from small hair, hair loss is serious, at least 30-40 hairs are removed when the hair is washed every time, more than ten hairs are removed when the hair is combed every morning, hair tips are dry, and the hair is easy to split. After using the product for 3 months, the hair is hardly lost during combing, the hair lost during washing is halved, and the hair quality is obviously improved.
Patient 2:
when a plum (Ningbo, female, 32 years old) grows, hair loss begins, the hair loss is reduced to 3/4 before the growth of children within 3 years, and particularly, the hair loss is serious after hair washing, hair roots are not firm, and hair is frigid and dry. After the product is used for one week, hair loss after hair washing is obviously reduced; after 2 months of use, the hair is only 1/5 original, and the hair is smooth.
Patient 3:
the life of a certain Wang university (Ningbo, male, 25 years old) is irregular, the university sleeps late, people eat heavy oil and hot substances, hair falls seriously in nearly four years, and the hairline moves backwards seriously. After the product is used for 3 months (and the living habits are changed within 3 months, the people sleep early and have light eating), the hair is hardly lost, 1-2 mm of hair grows on the hair line of the hair line which moves backwards, and the hair is burr and hard.
Patient 4:
king a certain (Ningbo, male, 41 years old) professionally sold, eating outside at least 4 days a week, with alopecia areata. Targeted therapy was done in hospitals but 2 episodes repeated. After the hair-growing liquid is used for 4 months (in continuous use), hair grows from the affected part by 1-2 mm.
Clinical observations 2
1. Clinical cases: 140 patients, female 70 and male 70 are selected in total, the cases are from different professional groups, and the alopecia phenomenon lasts for more than one year.
2. The eating method comprises the following steps: the selected population is randomly divided into 14 groups according to gender, 10 persons in each group eat the tabletted candies of comparative examples 1-6 and example 3, the specification is 0.75 g/tablet, the filling amount is 75 g/bottle, and the dosage can be increased or decreased according to the self constitution and personal symptoms.
3. The therapeutic effect judgment standard is as follows: the effect is shown: the hair loss phenomenon basically disappears, and a large number of new hairs grow out; the method has the following advantages: the hair loss quantity is reduced; and (4) invalidation: the symptoms of hair loss are substantially unchanged. The observation period is 4 months, and if the effect is shown within 4 months, the administration is stopped; if the symptoms did not improve after 4 months, it was judged to be ineffective.
4. Therapeutic effects
The results of the clinical data are shown in table 2.
Table 2: clinical data after taking tabletted confectioneries according to comparative examples 1-6 and example 3 of the invention
Figure BDA0002216992730000101
Figure BDA0002216992730000111
From the clinical data in table 2, it can be seen that the effective rate of the tablet candy prepared from the raw material formula of example 3 of the present invention can reach 90% after the tablet candy is taken by either female or male patients with alopecia, which is much higher than the tablet candy prepared from the raw material formulas of comparative examples 1 to 5 which lack at least one main material or auxiliary material, and the raw material formula of the present invention can achieve the purpose of treating alopecia from multiple angles through the reasonable compatibility of the main material and the auxiliary material. Meanwhile, in the case that the raw material formulas of example 3 and comparative example 6 are the same, comparative example 6 is different from example 3 of the present invention in terms of the preparation process thereof, and the clinical effect of the tabletted sweets prepared is far lower than that of the present invention. Therefore, the functional effect of the tabletted candy is the result of the mutual matching of the raw materials and the preparation method.
The technical scope of the invention claimed by the embodiments herein is not exhaustive and new solutions formed by equivalent replacement of single or multiple technical features in the embodiments are also within the scope of the invention, and all parameters involved in the solutions of the invention do not have mutually exclusive combinations if not specifically stated.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.

Claims (6)

1. The tablet candy for relieving alopecia is characterized by comprising the following traditional Chinese medicine raw materials in percentage by weight: 10-30% of black sesame, 10-30% of black bean, 5-15% of medlar, 5-15% of hawthorn, 5-15% of tuckahoe, 5-15% of coix seed, 5-10% of rhizoma polygonati, 5-10% of mulberry leaf, 5-10% of kudzu root, 5-10% of liquorice and 2-5% of donkey-hide gelatin.
2. The tabletted candy according to claim 1, comprising the following traditional Chinese medicine raw materials in percentage by weight: 12-25% of black sesame, 15-22% of black bean, 6-12% of medlar, 5-10% of hawthorn, 8-15% of tuckahoe, 6-12% of coix seed, 5-8% of rhizoma polygonati, 6-8% of mulberry leaf, 5-8% of kudzu root, 5-8% of liquorice and 2-4% of donkey-hide gelatin.
3. The tabletted candy according to claim 1 or 2, comprising the following traditional Chinese medicine raw material components in percentage by weight: 18% of black sesame, 18% of black bean, 9% of medlar, 7% of hawthorn, 10% of tuckahoe, 8% of coix seed, 7% of rhizoma polygonati, 7% of mulberry leaf, 6% of kudzu root, 7% of liquorice and 3% of donkey-hide gelatin.
4. A process for preparing a tabletted confectionery product as claimed in claim 1, comprising the steps of:
(1) weighing the raw materials according to the weight percentage of each component of the tabletted candy in claim 1 for later use;
(2) mixing the raw materials in the step (1), adding 8-10 times of water by weight, heating to boil, keeping slight boiling for 1-2 hours, and passing through a 250-350-mesh sieve while the mixture is hot to obtain a filtrate 1;
(3) adding water with the weight 5-8 times that of the residue sieved in the step (2) into the residue, heating the residue to boil, keeping the residue slightly boiling for 1-2 hours, and passing the residue through a 250-350-mesh sieve while the residue is hot to obtain a filtrate 2;
(4) mixing the filtrate 1 and the filtrate 2, concentrating and drying to obtain a powder semi-finished product;
(5) mixing the powder semi-finished product with food additive, and tabletting to obtain candy finished product.
5. The process for preparing a tabletted candy according to claim 4, wherein the concentration and drying in the step (4) comprises the following specific steps: concentrating the combined filtrate under the conditions of vacuum degree of-0.08 to-0.1 MPa and temperature of 70 to 80 ℃, and then spray-drying the concentrated solution at the temperature of 140 to 160 ℃.
6. The process for preparing a tabletted candy according to claim 4, wherein the food additive in step (5) is a mixture of xylitol and magnesium stearate, wherein xylitol accounts for 2-5% of the total amount of the semi-finished powder, and magnesium stearate accounts for 0.5-1.5% of the total amount of the semi-finished powder.
CN201910918880.3A 2019-09-26 2019-09-26 Pressed candy for relieving alopecia and preparation process thereof Pending CN110694013A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113068832A (en) * 2021-03-11 2021-07-06 苏州雷允上健康养生有限公司 A health product with effects of nourishing liver and kidney, fixing hair, and preventing alopecia, and its preparation method
CN115779051A (en) * 2022-10-22 2023-03-14 洋妆源(上海)网络科技有限公司 Compound traditional Chinese medicine for preventing hair loss and growing hair and application thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105477588A (en) * 2015-12-07 2016-04-13 聂全球 Traditional Chinese medicine capable of restoring and nourishing hair and production process thereof
CN109757720A (en) * 2019-03-26 2019-05-17 成都亮丽泉科技有限公司 A kind of health food of black hair and anti-aging

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105477588A (en) * 2015-12-07 2016-04-13 聂全球 Traditional Chinese medicine capable of restoring and nourishing hair and production process thereof
CN109757720A (en) * 2019-03-26 2019-05-17 成都亮丽泉科技有限公司 A kind of health food of black hair and anti-aging

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113068832A (en) * 2021-03-11 2021-07-06 苏州雷允上健康养生有限公司 A health product with effects of nourishing liver and kidney, fixing hair, and preventing alopecia, and its preparation method
CN115779051A (en) * 2022-10-22 2023-03-14 洋妆源(上海)网络科技有限公司 Compound traditional Chinese medicine for preventing hair loss and growing hair and application thereof
CN115779051B (en) * 2022-10-22 2023-11-21 洋妆源(上海)网络科技有限公司 Compound traditional Chinese medicine for preventing hair loss and growing hair and application thereof

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Application publication date: 20200117