CN105434932A

CN105434932A - Traditional Chinese medicine pill for treating female sexual precocity syndrome and preparation method thereof

Info

Publication number: CN105434932A
Application number: CN201510956954.4A
Authority: CN
Inventors: 夏修菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-18
Filing date: 2015-12-18
Publication date: 2016-03-30

Abstract

The invention discloses a traditional Chinese medicine pill for treating female sexual precocity syndrome and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The effective component of the pill is composed of the following raw materials by weight: 68 to 82 grams of jujube, 65 to 78 grams of wolfberry, 63 to 76 grams of American ginseng, 60 to 75 grams of white hyacinth bean, 58 to 70 grams of black sesame, 56 to 67 grams of polygonatum rhizome, 53 to 63 grams of rehmanniae radix, 48 to 60 grams of poria cocos, 44 to 56 grams of millet sprout, 41 to 55 grams of fructus citri, 38 to 52 grams of bighead atractylodes rhizome, 35 to 50 grams of sophora flower, 33 to 48 grams of mother of pearl, 30 to 45 grams of fleece-flower root, 28 to 42 grams of chrysanthemum, 26 to 39 grams of radix bupleuri, 24 to 36 grams of licorice, 21 to 32 grams of cyperus rotundus, 18 to 28 grams of white peony root, 12 to 25 grams of raw gardenia jasminoides, 9 to 20 grams of anemarrhena, 6 to 15 grams of ligustrum lucidum, 4 to 10 grams of sweet wormwood, and 1 to 6 grams of toosendan fruit. The selected traditional Chinese herbals are in accord with the principle of monarch, minister, assistant and guide in traditional Chinese medicine. The formula is developed to treat female sexual precocity syndrome. The pill has the functions of invigorating spleen, harmonizing the stomach, nourishing yin, tonifying kidney, clearing heat, and soothing the liver, has the advantages of good absorbing effect, prominent effect, no side or toxic effect, and no clinical adverse reaction, and has a high cure rate in clinic.

Description

One is used for the treatment of the syndromic medicine pill of female precocious puberty and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to one and be used for the treatment of the syndromic medicine pill of female precocious puberty and preparation method.

Background technology

Sexual precosity and Development in Puberty obviously shift to an earlier date, and female precocious puberty accounts for whole women's about 0.2 ‰.Because the time started variation of each normal children Development in Puberty is comparatively large, therefore be difficult to the absolute bound determining the normal and precocious time that Development in Puberty starts.It is generally acknowledged that any one or the multinomial secondary sex characteristics such as mammary gland increase, pubes growth, armpit hair growth appearred for 8 years old in girl in the past, or menarche starts from before 10 years old, be female precocious puberty, child's adolescence and sexual development grow the mean age 2 early than local normal children or 2.5 above persons of standard deviation are sexual precosity also to have scholar to advocate.Female precocious puberty is the common endocrinopathy of maiden section, can the reason of predictive precocity or diseased region according to hormonal readiness height.

Sexual precosity can be divided into true property, false and partial three types.True precocious puberty, infant growth order is similar to normal Paederus fuscipes Curtis, but shifts to an earlier date and accelerates, and this is that hypothalamus one hypophysis ~ gonad axis is started in advance, caused by hyperfunctioning, therefore reproductive function can be caused to occur in advance; Pseudo-precocious puberty is because gonadal tumor, adrenal cortical hyperplasia or tumor produce caused by a large amount of gonadal hormone, and because a large amount of gonadal hormone produces significant feedback inhibition to hypothalamus one hypophysis, therefore infant does not have reproductive performance; Partial sexual precosity mainly refers to that pure breast drought is grown, and grows and Acceleration of growth without other sex character.At present, true precocious puberty can account for 80% in sexual precosity women case.The cause of disease of sexual precosity mainly contains following several respects: the first, and it is too much that the imbalance of hypothalamic nerve, endocrine function or gonad, Adrenal lesion and intracranial tumor etc. cause sex hormones secretion; The second, women breast-feeding their children's long-term taking contraceptive, affects child by milk or child on long-term is taken containing estrogens growth encourage medicine and tonic food, as Radix Ginseng, Lac regis apis etc.; 3rd, only child's monophagia, surfeit, quite benefit phenomenon seriously, based on meat dish, are eaten vegetable, coarse grain, the chicken and duck flesh of fish, milk egg etc. less and are too much taken in animal proteinum, make nutrition cross Sheng; 4th, environment and food pollution, as the synthetic diet etc. used containing growth hormone a large amount of in poultry rearing process.Below are all the key factors causing children's's sexual precosity.

At present, the western medical treatment for children's sexual precocity mainly applies progestational hormone medicine and luteinizing hormone-releasing hormone class Drug therapy.Though the former can feedback suppression pituitary promoting sexual gland hormone, gonadal hormone decline secondary sex characteristics is disappeared, epiphysis can not be suppressed to merge too fast, therefore can not improve height, and prolonged application can make body weight increase, mild hypertension maybe can have certain infringement to liver function; Though then plant medicine both can suppress pituitary promoting sexual gland hormone, skeleton can be controlled again to overrun growth, but find in clinical practice, about most children is had an injection and is treated half a year, while sex hormone level reduces, child's height also suppresses no longer to grow tall, even if coordinate growth hormone therapy also to lack the checking of abundant clinical data, is that current doctor trained in Western medicine is had an injection a difficult problem for the treatment of and running into.Be exactly that latest research finds that the probability suffering from polycystic ovarian syndrome after the girl of injection treatment grows to manhood is higher than other children doubly a lot of in addition, be worth showing great attention to.

The complete documentation of sexual precosity is there is no in Chinese medicine ancient literature." Plain Questions.Ancient times innocence opinion " record: " woman seven years old, kidney qi is contained, and dental transition is sent out long, and 27 and the menarche, conception vessel leads to, and taichong channel is contained, regular menstrual cycle, therefore has son ".Reflection primary disease is sick appoints in punching, and root is kidney; Main pathogenesis is dampness-heat of the liver, spleen kidney deficiency, and the moon is YANG hyperactivity suppressing not, hyperactivity of the ministerial fire.Chinese traditional treatment focuses on distinguishes deficiency and excess, regulating YIN and YANG, rushes down it too, tonifying for deficiency syndrome.General excess syndrome shows as dampness-heat of the liver more, and controlling should pathogenic fire purging dampness removing.Deficiency syndrome then more shows as hyperactivity of the ministerial fire, and controlling should nourishing YIN and clearing away heat.But there is no the Chinese medicine invention formula of versatility at present, take ZHIBAI DIHUANG WAN, dabuyin pill etc. usually to medical patient, simple reply sexual precosity, there is significant limitation, and onset is not fully recovered slowly, cause effect barely satisfactory, Influence on test result doctor and the head of a family are to the true understanding of Chinese traditional treatment sexual precosity effect.

The present invention is through Long-term clinical checking, and find that the child of sexual precosity exists the sign of hyperactivity of fire caused by deficiency of YIN in various degree, sum up the primary disease cause of disease, modern children nutrition constantly improves, and adds and too much takes the tonic containing hormone such as Lac regis apis, pollen, colostrum element; Poultry is in cultivation, and adulterate in feedstuff hormonal growth thing; The film relevant with property, TV are full of the life of children; All factors all can cause brain gonad excretory system pre-cooling above, and make kidney yin not yet fill the child of Sheng, kidney qi fills too early.The prosperous fire-transformation of gas, kidney yin is relative deficiency again, unable restriction, so occur that fire is partially high mutually, causes sexual precosity.Therefore pill of the present invention, start with from invigorating the spleen and regulating the stomach, because of the health of spleen and stomach function, be life this, the source of growth promoter, spleen and stomach function perfects, and body development just can be normal, be train the benefit day after tomorrow and be suitable for congenital; Hold concurrently with enriching yin and nourishing kidney, heat clearing away is soothing the liver, reach soothing the liver circulation of qi promoting, pathogenic fire purging eliminating stagnation, Yu Kaijie is separated, cloudy Tianjin must be answered, and pathogenic heat are from moving back, and menses delays extremely.So treating both the principal and secondary aspects of a disease, reach the effect of qualcomm meridian, regulate yin-yang and internal organs, the secondary feature of various sexual precosity patient can be eliminated at short notice, delay the speedup of stone age, finally improve Patient height, short treating period, instant effect, cheap, have no side effect.

Summary of the invention

The invention provides one and be used for the treatment of the syndromic medicine pill of female precocious puberty and preparation method, there is invigorating the spleen and regulating the stomach, enriching yin and nourishing kidney, effect that heat clearing away is soothing the liver, cure the disease and ask source treating both the principal and secondary aspects of a disease, to the female precocious puberty that a variety of causes causes, all there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

One is used for the treatment of the syndromic medicine pill of female precocious puberty, and raw material composition and the parts by weight of making described effective ingredient are:

Fructus Jujubae 68 ~ 82g Fructus Lycii 65 ~ 78g Radix Panacis Quinquefolii 63 ~ 76g Semen Lablab Album 60 ~ 75g

Semen Sesami Nigrum 58 ~ 70g Rhizoma Polygonati 56 ~ 67g Radix Rehmanniae 53 ~ 63g Poria 48 ~ 60g

Fructus Setariae Germinatus 44 ~ 56g Fructus Citri Sarcodactylis 41 ~ 55g Rhizoma Atractylodis Macrocephalae 38 ~ 52g Flos Sophorae 35 ~ 50g

Concha Margaritifera 33 ~ 48g Radix Polygoni Multiflori 30 ~ 45g Flos Chrysanthemi 28 ~ 42g Radix Bupleuri 26 ~ 39g

Radix Glycyrrhizae 24 ~ 36g Rhizoma Cyperi 21 ~ 32g Radix Paeoniae Alba 18 ~ 28g Gardenia 12 ~ 25g

The Rhizoma Anemarrhenae 9 ~ 20g Fructus Ligustri Lucidi 6 ~ 15g Herba Artemisiae Annuae 4 ~ 10g Fructus Toosendan 1 ~ 6g.

Raw material composition and the parts by weight of making described effective ingredient are:

Fructus Jujubae 70 ~ 80g Fructus Lycii 68 ~ 75g Radix Panacis Quinquefolii 65 ~ 73g Semen Lablab Album 63 ~ 70g

Semen Sesami Nigrum 61 ~ 67g Rhizoma Polygonati 59 ~ 65g Radix Rehmanniae 55 ~ 60g Poria 50 ~ 56g

Fructus Setariae Germinatus 47 ~ 53g Fructus Citri Sarcodactylis 44 ~ 50g Rhizoma Atractylodis Macrocephalae 42 ~ 49g Flos Sophorae 38 ~ 46g

Concha Margaritifera 35 ~ 44g Radix Polygoni Multiflori 33 ~ 42g Flos Chrysanthemi 31 ~ 39g Radix Bupleuri 29 ~ 35g

Radix Glycyrrhizae 27 ~ 32g Rhizoma Cyperi 25 ~ 28g Radix Paeoniae Alba 20 ~ 25g Gardenia 15 ~ 22g

The Rhizoma Anemarrhenae 12 ~ 18g Fructus Ligustri Lucidi 8 ~ 12g Herba Artemisiae Annuae 6 ~ 8g Fructus Toosendan 2 ~ 4g.

Fructus Jujubae 75g Fructus Lycii 72g Radix Panacis Quinquefolii 70g Semen Lablab Album 66g

Semen Sesami Nigrum 64g Rhizoma Polygonati 62g Radix Rehmanniae 58g Poria 54g

Fructus Setariae Germinatus 50g Fructus Citri Sarcodactylis 48g Rhizoma Atractylodis Macrocephalae 45g Flos Sophorae 43g

Concha Margaritifera 42g Radix Polygoni Multiflori 38g Flos Chrysanthemi 35g Radix Bupleuri 32g

Radix Glycyrrhizae 30g Rhizoma Cyperi 26g Radix Paeoniae Alba 23g Gardenia 20g

Rhizoma Anemarrhenae 15g Fructus Ligustri Lucidi 10g Herba Artemisiae Annuae 7g Fructus Toosendan 3g.

Be used for the treatment of a preparation method for the syndromic medicine pill of female precocious puberty, comprise following processing step:

(1) Fructus Jujubae, Fructus Lycii, Radix Panacis Quinquefolii, Semen Sesami Nigrum, Rhizoma Polygonati, the Radix Rehmanniae, Fructus Setariae Germinatus, Fructus Citri Sarcodactylis, Concha Margaritifera, Flos Chrysanthemi, Radix Glycyrrhizae, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Artemisiae Annuae are cleaned, dried rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) Radix Polygoni Multiflori, the Radix Paeoniae Alba, Gardenia are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 5 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 4 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 4 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10 ~ 1.20, for subsequent use;

(3) clean for Semen Lablab Album drying is put into pot, fry to micro-yellow tool focal spot by frying method, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains segmentation, for subsequent use;

(4) Rhizoma Atractylodis Macrocephalae, Flos Sophorae are put into iron pan, the micro-stir-fry of slow fire, fry after turning yellow to epidermis, spray Ji Me Lao Jiu, after continuation stir-fry is sallow to epidermis, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(5) get Radix Bupleuri, Rhizoma Cyperi is cleaned, add quantitative rice vinegar and mix thoroughly, after moistening to vinegar is sucked, puts in parch container, heat fried dry with slow fire, taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) by Fructus Toosendan gross weight and core, clean to smash to pieces and dry, put into iron pan, slow fire is fried to micro-Huang, and taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of every 8g.

The property of medicine of the present invention's Chinese medicine used is as follows:

Fructus Jujubae: sweet in the mouth; Temperature.Return spleen; Stomach warp.Tonifying the spleen and stomach; Replenishing QI and blood; Tranquilizing mind; Battalion is adjusted to defend; And the property of medicine.Cure mainly: weakness of the spleen and stomach; Insufficiency of vital energy and blood; Anorexia and loose stool; Fatigue and weakness; Palpitation and insomnia; Woman hysteria; Disharmony of nutrient QI with defensive QI." herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines.Modern medicine study proves: Fructus Jujubae contains a large amount of protein, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and phosphorus, calcium, the nutrition such as ferrum and cyclic adenosine monophosphate, and the laudatory title with vitamin king.Fructus Jujubae has tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, effect of invigorating the spleen and regulating the stomach, is the pretty good health nutrient of weakness of the spleen and stomach patient.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.

Radix Panacis Quinquefolii: sweet in the mouth; Micro-hardship; Cold in nature.Return lung; Stomach; The heart; Kidney channel.Boosting qi and nourishing yin; Relieve inflammation or internal heat and promote the production of body fluid.Cure mainly: the cloudy specially hyperactivity of fire of the deficiency of vital energy, cough expectorant blood, deficiency-heat is tired tired, and interior-heat is quenched one's thirst, and dry mouth cigarette is done." book on Chinese herbal medicine asks former ": lung heat clearing kidney, cool heart spleen, with pathogenic fire reducing, is relieved summer heat, is relieved the effect of alcohol.Modern study proves: the Saponin in Radix Panacis Quinquefolii effectively can strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing; Radix Panacis Quinquefolii can arrhythmia, resist myocardial ischemia, anti-cardiac muscle oxidation, strengthening cardiac contractility ability; Radix Panacis Quinquefolii can improve immunity of organisms, reduces blood coagulability, suppresses platelet aggregation, atherosclerosis promote Growth of red blood cells, increase hematochrome; Radix Panacis Quinquefolii can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, has certain assosting effect to treatment diabetes.

Semen Lablab Album: slightly sweet flavor; Slightly warm in nature; Flat.Return spleen, stomach warp.Spleen invigorating, removing dampness, relieves summer heat.For weakness of the spleen and stomach, inappetence, stool sugar rushes down, leukorrhagia, and heat-damp in summer is vomited and diarrhoea. abdominal distention uncomfortable in chest.Modern medicine study proves: Semen Lablab Album has antibacterial, antivirus action, strengthens immunity function, has certain anti-tumor activity.Semen Lablab Album mineral and vitamin content are very high, have tonifying the spleen and stomach, and middle removing dampness, the effect of relieve summer heating Detoxication.

Semen Sesami Nigrum: property is put down, sweet in the mouth.Return Liver Channel, kidney channel, large intestine channel.Liver and kidney tonifying; The benefit that nourishes blood essence; Loosening bowel to relieve constipation.With the dizziness and tinnitus caused by treating the liver kidney deficiency, waist foot flaccidity is soft, beard and hair is early sent out, scaly dry skin; Dryness of the intestine constipation; Married woman's breast is few; Carbuncle skin ulcer eczema; Wind leprosy scrofula infections; Infantile scrofula; Burn; Hemorrhoid.Modern study proves: the fatty oil of Semen Sesami Nigrum, sesamin, vitamin E and various trace elements etc.There is reduction blood glucose, increase the content of glycogen in liver and muscle, increase the effect such as Vitamin C bolt and cholesterol level, defying age, relieving constipation, suppression adrenal cortex function in adrenal gland.

Rhizoma Polygonati: sweet in the mouth; Flat.Return spleen; Lung; Kidney channel.Nourishing YIN and moistening the lung; Invigorating the spleen and replenishing QI, Zishen fill fine.Cure mainly: deficiency of YIN chronic cough; Xeropulmonary cough; Insufficiency of the spleen weak; Lack of appetite xerostomia; Quench one's thirst; Deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; Tinnitus order is dark; Early whitening of beard and hair; Body void is won thin; Wind favus disease." herbal classic is met former ": Rhizoma Polygonati, alleviating distention in middle-JIAO QI invigorating, five Tibetan are in harmonious proportion, and muscle sufficiency, bone marrow is hard by force, is all the merit of nourishing YIN.Modern study proves: Rhizoma Polygonati comprises polysaccharide, aminoacid, the multiclass nutrient substance such as nicotinic acid.In addition strengthen coronary flow in addition, reduce blood pressure and the pharmacological action of blood glucose.

The Radix Rehmanniae: sweet in the mouth; Bitter; Cold nature.GUIXIN; Liver; Kidney channel.Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Cure mainly calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease sends out speckle; Haematemesis caused by heat in blood; Metrorrhagia; Hematuria; Have blood in stool; Blood deficiency and yellow complexion; Dizzy cardiopalmus; Insufficiency of blood amenorrhea." Japan hanako materia medica " carries: " control palpitation with fear labor bad, cardiopulmonary damage, and spit blood, epistaxis, married woman's metrorrhagia bruise, helps muscles and bones." modern medicine study confirms, the Radix Rehmanniae is effective immunostimulant, comprises multiclass aminoacid, the saccharide beneficial to human body, and have heart tonifying, diuresis, blood pressure lowering, blood sugar lowering, protect the liver, the pharmacological action such as antibacterial, hemocytes increasing.

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine." not Lu " carries: " only quench one's thirst, like to sleep, large abdomen, drench drop, the disease due to obstruction of QI of middle-JIAO expectorant water, edema drenches knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; have certain protective effect to digestive system, blood system and central nervous system; pachyman content is very high in addition, can anti-tumor activity.

Fructus Setariae Germinatus: sweet in the mouth; Flat.Return spleen; Stomach warp.Promoting digestion and removing stagnation; Spleen benefiting and stimulating the appetite.Cure mainly: food stagnation is stagnated; Distension is had loose bowels; Insufficiency of the spleen few food; Beriberi edema." Bencao Jingshu ": tiller rice and rice tiller are also.The property of tool biochemistry, thus be digestion-promoting spleen-invigorating, appetizing and in key medicine, taste and then in from pestilence, gas under, heat is from except also.

Fructus Citri Sarcodactylis: acrid in the mouth; Bitter; Warm in nature.Enter liver; Stomach; Spleen; Lung meridian.Dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, invigorating the spleen and regulating the stomach.Cure mainly the hypochondriac pain of depression of liver-QI; Breast is vexed; Incoordination between the liver and stomach; The abdominal distention of stagnation of QI in spleen and stomach; Yuan gas; Feel sick; Chronic cough abundant expectoration." book on Chinese herbal medicine is new again " carries: " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." modern medicine study confirmation; Fructus Citri Sarcodactylis has phlegm-dispelling functions of relievining asthma; antagonism airway constriction; the tension force alleviating rapidly stomach, intestinal and gallbladder increases; extend convulsions time of origin, prevention arrhythmia, the resistance of increase strong wool blood vessel; reduce the ascorbic discharge of adrenal gland, also have the effect of antiinflammatory, antimicrobial acivity in addition.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement." herbal classic is met former " carries: " art, raw with there being dehumidifying benefit dry, expectorant diuretic, controls anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer, blood between loose waist umbilicus, and chong channel is disease, the merit of inverse gas pain in the abdomen; Make ripe, have and middle QI invigorating, slake thirst and help produce saliva, hidroschesis heat extraction, enters diet, antiabortive effect." modern medicine study confirmation, the Rhizoma Atractylodis Macrocephalae has effect that is strong and raising body resistance against diseases, strengthen the phagocytic function of reticuloendothelial system, strengthen the function of leukocytes phagocytic staphylococcus aureus, leukogenic effect is had to leukopenia, improve lymhocyte transformation rate, promote cellular immune function, to staphylococcus aureus, Hemolytic streptococcus, viridans streptococci, streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus subtilis has inhibitory action in various degree, to acrothesium floccosum, star-shaped nocardia, trichophyton, the dermatophytess such as Trichophyton concentricunm have certain inhibitory action.

Flos Sophorae: bitter in the mouth; Cold nature.Enter liver; Lung; The heart; Large intestine channel.Cooling blood for hemostasis; Fire is let out in liver heat removing.Cure mainly discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat is had a headache; Conjunctival congestion and swelling pain; Carbuncle skin infection." book on Chinese herbal medicine just " carries: " cool large intestine kills infantile malnutrition worm.Control skin sore, erosion of vulva pruritus due to damp pathogen, anal fistula, separate Fructus Myricae rubrae malignant boil, primary sore volt poison." modern medicine study confirms, Flos Sophorae containing globulariacitrin, sophoradiol, glucose and glucuronic acid and tannin, have antiinflammatory action, have inhibitory action equally to viral and dermatophytes; Globulariacitrin also can strengthen capillary resistance, improves blood vessel wall fragility, reduces blood pressure, edema, hypertension is had to the effect preventing rupture of blood vessel in brain, the action and efficacy such as Flos Sophorae also has coronary artery dilator in addition, blood fat reducing.

Concha Margaritifera: sweet in the mouth; Salty; Cold in nature.Return liver; Heart channel.Suppressing the hyperactive liver and subsiding YANG; To calm the nerves arresting convulsion; Liver heat removing and eyesight improving.Cure mainly: have a headache dizzy; Palpitation and insomnia; Demented infantile convulsion; Liver-heat conjunctival congestion; Pterygium." Chinese medicine voluminous dictionary ": liver nourishing is cloudy, clearing away liver-fire.Control demented infantile convulsion, dizziness, tinnitus, heart beating, pleuroperitoneum is swollen, women's heat in blood, metrorrhagia, and frightened the jerking of children's sends out convulsion.Modern medicine study proves: main containing calcium carbonate more than 92%, obtains 17 seed amino acids such as glycine, alanine and leucine after the hydrolysis of internal layer angle glutelin.Still containing multiple inorganic elementss such as aluminum, copper, ferrum, magnesium.Margarita layer powder hydrolysate also has obvious curative effects to incipient cataract.Margarita layer powder also has antioxidation, after patients with coronary heart disease takes 1 month continuously, Serum LPO Levels can be made obviously to reduce.Middle-aged and elderly people took Margarita layer powder after 2 months, and memory and motor capacity make moderate progress, and cellular immune function increases.

Radix Polygoni Multiflori: bitter in the mouth; Sweet; Puckery; Slightly warm in nature.Return liver; Kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Cure mainly: blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid." book on Chinese herbal medicine is just ": the Radix Polygoni Multiflori, specially enters Liver and kidney, take a tonic or nourishing food to build up one's health Kidney-Yin, and taste is admittedly very thick, and slightly hold concurrently pained, property is then gentle, and the reason of all sealing Tibetan with the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels meets, therefore can fill out beneficial vital essence, has negative and positive and puts down secret effect, and non-relatively the moon as Radix Rehmanniae is solidifying comparable.Good Gu meaning eliminating pathogen in the liver wind, be that the moon does not contain sun, water does not support wood, is cause the raw wind of edema with the liver involved, and this energy nourishing YIN, then control wind and first control blood, and blood wind is from going out, and also its institute is suitable.But this nourishes with endogenous wind stopping, must take for eliminating pathogen in the liver.

Flos Chrysanthemi Indici: bitter in the mouth; Pungent; Property is put down.Enter lung; Liver Channel.Heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Cure mainly furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension." book on Chinese herbal medicine converges and says " carries: " removing blood stasis is soothing the liver; Separate the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." modern medicine study confirmation, Flos Chrysanthemi Indici has broad-spectrum antibacterial action, all has stronger inhibitory action to most dermatophytes, staphylococcus aureus, dysentery bacterium, bacillus pyocyaneus and influenza virus, also has the effect of blood pressure lowering, blood fat reducing, preventing cold.

Radix Bupleuri: bitter in the mouth; Pungent; Cold nature.Return liver; Gallbladder meridian.Induce sweat and bring down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis." detailed outline ": " control yang-energy to sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery, and headache, dizzy, and blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition." modern medicine study confirms, Radix Bupleuri has antipyretic, calm, analgesia, antitussive, antiinflammatory action.Resist hepatic injury, function of gallbladder promoting, anti-fatty liver simultaneously, and promote that enterokinesia etc. has certain effect.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.Dispersing the stagnated live-QI to relieve the stagnation of QI; Menstruction regulating and pain relieving; Regulate the flow of vital energy in adjusting; Antiabortive.With treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses etc." detailed outline " carries: " loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, Xie Nvyu, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; hematochezia, hematuria, married woman's bleeding not during menses, menoxenia, before tire puerperal all kinds of diseases and ailments." modern medicine study proves, Rhizoma Cyperi energy nervous system regulation function, has heart tonifying, decreased heart rate, reduces blood pressure, prevents and treats the effect such as hyperlipemia and atherosclerosis.This product also has relaxing smooth muscle and estrogen-like effects, has the pharmacological action such as antiinflammatory, hepatic cholagogic.

The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, pain relieving in slow; Yin fluid astringing receives antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency." not Lu " carries: " clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when controlling, and attacked by pestiferous factors is suffered from abdominal pain, lumbago." modern medicine study confirms; Radix Paeoniae Alba energy immunity moderation; strengthen macrophage and leukocytic phagocytic function; regulate the immunologic function of T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, anti-cool, cooling effect; have inhibitory action to smooth muscle in addition, strengthen the effect of anoxia enduring, antioxidation and resisting fatigue.

Gardenia: bitter in the mouth; Cold in nature.Enter the heart; Liver; Lung; Stomach; Tri-jiao channel.Pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Damp and hot yellow infantile malnutrition; Stranguria; Hematemesis and epistaxis; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.Materia Medica of Decoction carries: " also, normal lung-QI and changing, bladder is the mansion of body fluid, and urine obtains this gasification and goes out also in lung heat clearing for Fructus Gardeniae diuresis, real non-diuresis." modern medicine study confirms; Fructus Gardeniae is containing flavonoid gardenin; Aqueous extracts has obvious potentiation to bile secretion; have obvious contraction to gallbladder; and can reduce in blood and bilirubin in tip lymph fluid; promote that blood mesobilirubin is drained rapidly, and geniposide has and promotes pancreatic secretion and have the effect significantly reducing pancreatic amylase, and can increase pancreas gallbladder flow.

The Rhizoma Anemarrhenae: bitter in the mouth; Cold in nature.Enter lung; Stomach; Kidney channel.Clearing away heat-fire; Nourshing Yin and drynsessmoistening prescription; To quench the thirst relieving restlessness.Cure mainly epidemic febrile disease; High hot excessive thirst; Cough and asthma; Cough caused by dryness; Constipation; Osteopyrexia and fever; Restlessness of asrhenia type and insomnia; To quench one's thirst stranguria with turbid discharge." property of medicine opinion " carries: " cure mainly vexed hot-tempered vexed, the strain of bone heat, general debility during puerperium, kidney qi labor, the loathing of cold is deficient, suffers from the empty and xerostomia of people, adds and use it." modern medicine study confirms, the Rhizoma Anemarrhenae can suppress liver to the catabolism of hydrocortisone, has inhibitory action to multiple pathogenic microorganisms, reduces blood glucose, Tumor suppression growth and the effect of platelet aggregation in addition in addition.

Fructus Ligustri Lucidi: sweet in the mouth; Bitter; Cool in nature.Return liver; Kidney channel.Liver and kidney tonifying; Clearind deficient heat; Improving eyesight.Cure mainly Light-headedness; Soreness of the waist and knees; Seminal emission; Tinnitus; Early whitening of beard and hair, osteopyrexia and fever; Poor vision." book on Chinese herbal medicine is new again ": replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods multiple element, there are heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.Fructus Ligustri Lucidi has enhancing body fluid and cellular immune function, reduces blood fat, reduces blood glucose, protects the liver, improve the pharmacological actions such as protein metabolism.Patient worn with age usually takes can disease-relieving and physique enhancing, improves body function.

Herba Artemisiae Annuae: bitter in the mouth; Micro-pungent; Cold in nature.Return liver; Gallbladder meridian.Heat clearing away; Expelling summer-heat; Except steaming; Preventing the attack (or recurrence) of malaria.Cure mainly summer-heat; Expelling summer-heat; Hygropyrexia; Fever due to yin deficiency; Malaria; Jaundice." Treatise on Dietetic Therapy " carries: " QI invigorating, long hair, invigorating middle warmer, improving eyesight, very pathogenic wind toxic.Control hectic fever due to YIN-deficiency." modern medicine study confirms; report thing carried by Herba Artemisiae Annuae significant malaria, parasiticide effect; have certain inhibitory action to staphylococcus epidermidis, micrococcus catarrhalis, staphylococcus aureus, tubercule bacillus; improve lymhocyte transformation rate; promote cellular immune function, contained arteannuin energy decreased heart rate, suppresses myocardial contraction; reduce coronary flow, in addition antipyretic, blood pressure lowering and radiation protection in addition.

Fructus Toosendan: bitter in the mouth; Cold in nature, slightly poisonous.Return liver; Small intestinal; Urinary bladder channel.Soothing the liverly to expel the heat-evil; Promoting the circulation of QI to relieve pain; Parasite killing.Cure mainly the gastral cavity abdomen pain over the hypochondriac region; Hernia pain; Abdominal pain due to worm stagnation; Tinea capitis." medical center bun is wanted ": " eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire.Core: happy hernia, removes syndrome of aversion to cold lasting day and night with cold limbs." modern medicine study confirms, the Fructus Toosendan contained by Fructus Toosendan have ascarifuge effect, has certain inhibitory action to central nervous system, also has certain anti-botulism effect in addition.

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material monarch, minister, a left side, makes all reasons all standby, the property of medicine is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease such as deficiency of the liver and kindey, hyperactivity of fire caused by deficiency of YIN causing female precocious puberty, there is invigorating the spleen and regulating the stomach, enriching yin and nourishing kidney, effect that heat clearing away is soothing the liver, cure the disease and ask source treating both the principal and secondary aspects of a disease, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to female precocious puberty cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

The processing step of process for preparing medicine of the present invention is:

Usage and dosage: oral, every day 3 times, each 1 ball, one hour ante cibum, with warm water delivery service, 30 days was a course for the treatment of.

Embodiment 2

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

Semen Sesami Nigrum 64g Rhizoma Polygonati 62g Radix Rehmanniae 58g Poria 54g

Radix Glycyrrhizae 30g Rhizoma Cyperi 26g Radix Paeoniae Alba 23g Gardenia 20g

Clinical data:

1, case selection

The routine clinical observation of female precocious puberty patient 80 selecting my institute to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 example, 5 ~ 10 years old age, 7.4 years old mean age.Matched group 40 example, 4 ~ 10 years old age, 7.3 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, every day 3 times, each 1 ball, and one hour ante cibum, with warm water delivery service, 30 days was a course for the treatment of, took 3 courses for the treatment of.Matched group, according to the classification of the female precocious puberty diagnosed out, gives progestational hormone medicine and luteinizing hormone-releasing hormone class medicine is treated respectively.

3, efficacy determination:

(1) cure: menstruation termination, secondary sex characteristics is grown and is recovered normal, and every Index for examinations such as stone age test, FSH and LH mensuration and Visual quality inspection recover normal substantially.

(2) take a turn for the better: menstruation stops, secondary sex characteristics is grown and is obviously slowed down, and every Index for examinations such as stone age test, FSH and LH mensuration and Visual quality inspection obviously improve.

(3) invalid: symptom is with treating front no significant difference.

4, result

Cure 17 examples in treatment group, take a turn for the better 19 examples, invalid 4 examples, cure rate 42.5%, total effective rate 90%.

Cure 11 examples in matched group, take a turn for the better 21 examples, invalid 8 examples, cure rate 27.5%, total effective rate 80%.

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is illustrated:

1, Lee's ××, female, 6 years old.There is little lump at the right newborn position of this Finding case, and firmly by being pressed with pain, left newborn unclear location shows.Institute's inquiring afterwards, after inspection, is diagnosed as female precocious puberty, take medicine of the present invention, every day 3 times, each 1 ball, one hour ante cibum is with warm water delivery service, it within 30 days, is a course for the treatment of, after taking 3 courses for the treatment of, right newborn position lump disappears, and pain disappears completely, every Index for examination recovers normal, fully recovers.

2, Zhao's ××, female, 7 years old.Its father and mother find that in the process of once having a bath the breast of 7 years old daughter to daughter has germinated unexpectedly, occurred the lump of egg size, and vagina place there has also been the secretions of a small amount of similar adult in child's two micromazias.Institute's inquiring afterwards, after inspection, be diagnosed as female precocious puberty, take medicine of the present invention, every day 3 times, each 1 ball, one hour ante cibum, with warm water delivery service, 30 days was a course for the treatment of, after taking 3 courses for the treatment of, clinical examination recovers normal substantially, and after continuing to take 2 courses for the treatment of of pill of the present invention, further consultation is fully recovered.

The medical material property of medicine selected in pill of the present invention is suitable mutually auxiliary mutually, Chinese medicine invigorating the spleen and regulating the stomach, the promoting digestion and removing stagnation such as Poria, Fructus Setariae Germinatus, Fructus Citri Sarcodactylis in side; Chinese medicine invigorating the spleen and benefiting QI, the dampness diuretic such as Rhizoma Polygonati, Semen Lablab Album, Fructus Jujubae, Rhizoma Atractylodis Macrocephalae in side; Chinese medicine liver and kidney tonifying, the boosting qi and nourishing yin such as Radix Panacis Quinquefolii, Fructus Lycii, Semen Sesami Nigrum, Radix Polygoni Multiflori, Fructus Ligustri Lucidi in side; The Chinese medicine such as Radix Bupleuri, Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI in side, induce sweat and bring down a fever; The Chinese medicines such as side ZHONGJUHUA, Gardenia, the Rhizoma Anemarrhenae, Herba Artemisiae Annuae, Fructus Toosendan are soothing the liver to expel the heat-evil, nourshing Yin and drynsessmoistening prescription, pathogenic fire purging relieving restlessness; Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription in side.Pill of the present invention has invigorating the spleen and regulating the stomach, enriching yin and nourishing kidney, effect that heat clearing away is soothing the liver, cures the disease and asks source treating both the principal and secondary aspects of a disease, good absorbing effect, evident in efficacy, has no side effect and clinical adverse, higher to female precocious puberty cure rate through clinical verification.

Claims

1. be used for the treatment of the syndromic medicine pill of female precocious puberty, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

2. one according to claim 1 is used for the treatment of the syndromic medicine pill of female precocious puberty, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

3. one according to claim 1 is used for the treatment of the syndromic medicine pill of female precocious puberty, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

4. a kind of preparation method being used for the treatment of the syndromic medicine pill of female precocious puberty according to claims 1 to 3, is characterized in that, comprise following processing step: