CN105194295A - Medicine composition for treating diabetes - Google Patents
Medicine composition for treating diabetes Download PDFInfo
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- CN105194295A CN105194295A CN201510749059.5A CN201510749059A CN105194295A CN 105194295 A CN105194295 A CN 105194295A CN 201510749059 A CN201510749059 A CN 201510749059A CN 105194295 A CN105194295 A CN 105194295A
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Abstract
The invention provides a medicine composition for treating diabetes. The medicine composition is characterized in that a prescription of the medicine composition comprises 1-28 parts of radix codonopsis, 1-28 parts of fresh rehmannia root, 1-28 parts of cassia bark, 1-28 parts of prepared common monkshood daughter root, 1-22 parts of raw common anemarrhena rhizome, 1-22 parts of Chinese magnoliavine fruit, 1-10 parts of motherwort herb, 1-10 parts of dwarf lilyturf tuber and 1-10 parts of costustoot by weight. A medicine composition preparation comprises the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. The dosage forms of the preparation include a water decoction, a pill, a tablet, a capsule, granules, instant granules and oral liquid. The composition has obvious curative effects on patients with yin-yang deficiency type diabetes and does not have toxic or side effect.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of diabetes.
Background technology
In recent years, more next higher of the sickness rate of diabetes.2.2 hundred million patients from 1.5 hundred million patients of 2000 by 2010, increased numbers has exceeded 45%, also lack of uniformity is shown in Area distribution, Asian-Pacific area developing country rate of increase exceeds more than 10 percentage points than average rate of increase, China's year increases diabetics number and has exceeded 1,200,000.Diabetes form is more and more severeer.
Treatment at present to diabetes, most based on Western medicine blood sugar lowering (as sulphanylureas, biguanides, glycosidase inhibitor, thiazolidinedione, insulin) clinically.And these traditional antidiabetic drugs are just as a double-edged sword, although blood glucose can be reduced in short time table, alleviate the harm that hyperglycemia is brought.But they still can increase the weight of the danger of diabetic complication death from two aspects.Long-term drug dependence, can make to produce high amount of drug toxin deposition in body, all can have very large infringement to the heart of human body, liver, lung, renal function, thus accelerate the arrival of complication.While human body produces rely on hypoglycemic medicine, also can strengthen drug resistance, blood sugar level can be made more to be difficult to control, and occur that blood glucose is fluctuated, this is easier than simple hyperglycemia causes complication.
The traditional Chinese medical science thinks that the five internal organs are weak mainly due to the ferritic deficiency of YIN, multiple because of eating and drinking without temperance, surfeit delicious food, disorder of emotion, and labor for excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, and scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and consumption Tianjin liquid that burns makes blood viscous, and blood is not smooth forms the stasis of blood; Deficiency of YIN affecting YANG, yang deficiency cold coagulation, also can cause sun in blood stasis.Yang-yin asthenia type diabetes, is more common in diabetic duration comparatively elder.Clinical manifestation: weak spontaneous perspiration; The burnt universe of coldness of the body with chills, soreness of the waist and knees, helix; Polydipsia polyuria, muddiness are as cream; Or edema oliguria or diarrhea before dawn, impotence and premature ejaculation; Pale tongue with white fur, deep,thready and forceless pulse, main employing warming YANG nourishing YIN method.
Summary of the invention
The present invention aims to provide a kind of pharmaceutical composition for the treatment of yang-yin asthenia type diabetes.
For achieving the above object, a kind of pharmaceutical composition for the treatment of diabetes of the present invention, its concrete scheme is:
A kind of pharmaceutical composition for the treatment of diabetes of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Codonopsis 1-28 part, fresh Radix Rehmanniae 1-28, Cortex Cinnamomi 1-28 part, Radix Aconiti Lateralis Preparata 1-28 part, raw Rhizoma Anemarrhenae 1-22 part, Fructus Schisandrae Chinensis 1-22 part, Herba Leonuri 1-10 part, Radix Ophiopogonis 1-10 part, Radix Aucklandiae 1-10 part.
A kind of pharmaceutical composition for the treatment of diabetes of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Codonopsis 5-22 part, fresh Radix Rehmanniae 5-22, Cortex Cinnamomi 5-22 part, Radix Aconiti Lateralis Preparata 5-22 part, raw Rhizoma Anemarrhenae 3-16 part, Fructus Schisandrae Chinensis 3-16 part, Herba Leonuri 2-8 part, Radix Ophiopogonis 2-8 part, Radix Aucklandiae 2-5 part.
The pharmaceutical composition of a kind of diabetes of the present invention, is characterized in that these pharmaceutical composition parts by weight are counted: Radix Codonopsis 18 parts, the fresh Radix Rehmanniae 18, Cortex Cinnamomi 18 parts, Radix Aconiti Lateralis Preparata 18 parts, the raw Rhizoma Anemarrhenae 12 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leonuri 6 parts, Radix Ophiopogonis 6 parts, the Radix Aucklandiae 3 parts.
The preparation of Chinese medicine composition of the present invention, is characterized in that, described preparation is oral formulations.
Preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
Preparation of the present invention, is characterized in that, described preparation is tablet.
Preparation of the present invention, is characterized in that, the preparation method of described tablet is: the medical material getting recipe quantity is mixed in proportion and adds 6-15 times of soak by water 0.5-3h, decocts 1-2 time, merges decoction liquor; Decoction liquor is concentrated into solid-liquid ratio 0.5-2, regulate determining alcohol to 60-85% after adding ethanol, dark place leaves standstill 10-36h, filters, and reclaims ethanol, is concentrated into thick paste, density 1.2-1.5(40-60 DEG C), dry, pulverize 80 mesh sieves, for subsequent use.Add adjuvant, 70% ethanol soft material, granule processed, dry, compress tablet coating, to obtain final product.
The preparation method of preparation of the present invention, is characterized in that, described decocting time is 2h, adds 8 times of water, decocts number of times 2 times, and solid-liquid ratio is 1:1.5, determining alcohol 70%, standing 16h.
Preparation of the present invention, it is characterized in that, the adjuvant of preparing of described tablet is: one or more combinations in sucrose, lactose, mannitol, soluble starch, dextrin, stevioside, aspartame, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvidone, micropowder silica gel, magnesium stearate, Polyethylene Glycol, polyvinyl alcohol, Opadry.
The application of Chinese medicine composition of the present invention in preparation treatment yang-yin asthenia type diabetes medicine.
The each component pharmacology analysis of prescription of the present invention:
Radix Codonopsis: sweet in the mouth, property is put down; Have invigorating the spleen and replenishing QI, quench the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid; For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
The Radix Rehmanniae: sweet in the mouth is flat, nontoxic; GUIXIN, liver, kidney channel; Energy tonifying deficiency, warming the middle warmer and descending qi, promoting blood circulation.
Cortex Cinnamomi: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation; .Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Radix Aconiti Lateralis Preparata: recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain.
The Rhizoma Anemarrhenae: property bitter cold, has nourishing YIN to lower pathogenic fire, moisturizes laxation, the effect of sharp defecation; Gunpowder under genus heat clearing away.
Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission; Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Herba Leonuri: acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappears water, treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
Radix Ophiopogonis: sweet, micro-hardship, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness, cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis Radix Ophiopogonis.
The Radix Aucklandiae: pungent acrid in the mouth; Bitter; Warm in nature.Circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.
Beneficial effect of the present invention is: Chinese medicine composition of the present invention, should based on warming YANG nourishing YIN according to treatment yang-yin asthenia type diabetes, with card assistant with heat clearing away, the principle of invigorating blood circulation, utilize pharmaceutical composition warming YANG of the present invention and without rising floating fraud, nourishing YIN has the merit of activating QI concurrently, then takes to adjust rule of life, strikes a proper balance between work and rest, to be careful in one's diet etc. and to be conducive to setting up live and work order that is happy, rule, effect for the treatment of both the principal and secondary aspects of a disease can be reached diabetes.
Beneficial effect of the present invention is:
1. prescription scientific formulation, evident in efficacy;
2. prescription crude drug source is wide, and technique is simple, is applicable to large-scale production, has industrialization prospect.
Detailed description of the invention
Embodiment is only for further illustrating the present invention below, does not limit the scope of the invention in any form.
Embodiment 1
Present composition water decoction prescription and preparation method: Radix Codonopsis 18 parts, the fresh Radix Rehmanniae 18, Cortex Cinnamomi 18 parts, Radix Aconiti Lateralis Preparata 18 parts, the raw Rhizoma Anemarrhenae 12 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leonuri 6 parts, Radix Ophiopogonis 6 parts, the Radix Aucklandiae 3 parts.Mixing, adds the water of 6 times of quality, decocts 2 hours by crude drug, filter; Medicinal residues add the water of 4 times of quality again, decoct 45 minutes, filter; Merge twice filtrate, make water decoction.
Embodiment 2
Present composition tablet formulation and preparation method:: Radix Codonopsis 18 parts, the fresh Radix Rehmanniae 18, Cortex Cinnamomi 18 parts, Radix Aconiti Lateralis Preparata 18 parts, the raw Rhizoma Anemarrhenae 12 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leonuri 6 parts, Radix Ophiopogonis 6 parts, the Radix Aucklandiae 3 parts.The medical material getting recipe quantity is mixed in proportion and adds 8 times of soak by water 2h, decocts 2 times, merges decoction liquor; Decoction liquor is concentrated into solid-liquid ratio 1:1.5, regulate determining alcohol to 70% after adding ethanol, dark place leaves standstill 16h, filters, and reclaims ethanol, is concentrated into thick paste, density 1.2-1.3(40-60 DEG C), dry, pulverize 80 mesh sieves, for subsequent use.Add sucrose, lactose, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvidone, 70% ethanol soft material, granule processed, dry, add micropowder silica gel, tabletting, Opadry coating, to obtain final product.
Embodiment 3
Present composition capsule prescription and preparation method: Radix Codonopsis 18 parts, the fresh Radix Rehmanniae 18, Cortex Cinnamomi 18 parts, Radix Aconiti Lateralis Preparata 18 parts, the raw Rhizoma Anemarrhenae 12 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leonuri 6 parts, Radix Ophiopogonis 6 parts, the Radix Aucklandiae 3 parts.The medical material getting recipe quantity is mixed in proportion and adds 10 times of soak by water 2h, decocts 2 times, merges decoction liquor; Decoction liquor is concentrated into solid-liquid ratio 1:2, regulate determining alcohol to 70% after adding ethanol, dark place leaves standstill 15h, filters, and reclaims ethanol, is concentrated into thick paste, density 1.2-1.3(40-60 DEG C), dry, pulverize 80 mesh sieves, for subsequent use.Add sucrose, lactose, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvidone, 70% ethanol soft material, granule processed, dry, add micropowder silica gel, encapsulated, to obtain final product.
Embodiment 4
One, physical data accept for medical treatment yang-yin asthenia type diabetes patient totally 100 example, age 35-75 year;
Two, Therapeutic Method and judgment criteria are according to Medications Example 2 of the present invention, and Rezulin compositions prepared by preferred preparation method, and each 2, one day 3 times 2 months is a course for the treatment of, observes 1 course for the treatment of;
Pass judgment on:
Effective: dry mouth and throat, nocturia, aversion to cold and cold limbs, fatigue and weakness, dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, loose stool limb swells, seminal emission sexual impotence, and enlarged tongue tongue is white, and the symptoms such as thready pulse without strength disappear substantially;
Blood glucose obviously declines;
Take a turn for the better: dry mouth and throat, nocturia, aversion to cold and cold limbs, fatigue and weakness, dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, loose stool limb swells, seminal emission sexual impotence, and enlarged tongue tongue is white, and the symptoms such as thready pulse without strength obviously reduce, and blood glucose obviously declines;
Invalid: dry mouth and throat, nocturia, aversion to cold and cold limbs, fatigue and weakness, dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, loose stool limb swells, seminal emission sexual impotence, and enlarged tongue tongue is white, and thready pulse without strength symptom etc. is not improved, and blood glucose declines not obvious;
Three, after therapeutic outcome statistics 1 course for the treatment of of treatment, effective 52 people, take a turn for the better 40 people, invalid 8 people, total effective rate 92%.Wherein: total effective rate=obvious effective rate+improvement rate.
Claims (10)
1. treat a pharmaceutical composition for diabetes, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Codonopsis 1-28 part, fresh Radix Rehmanniae 1-28, Cortex Cinnamomi 1-28 part, Radix Aconiti Lateralis Preparata 1-28 part, raw Rhizoma Anemarrhenae 1-22 part, Fructus Schisandrae Chinensis 1-22 part, Herba Leonuri 1-10 part, Radix Ophiopogonis 1-10 part, Radix Aucklandiae 1-10 part.
2. a kind of pharmaceutical composition for the treatment of diabetes according to claim 1, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Codonopsis 5-22 part, fresh Radix Rehmanniae 5-22, Cortex Cinnamomi 5-22 part, Radix Aconiti Lateralis Preparata 5-22 part, raw Rhizoma Anemarrhenae 3-16 part, Fructus Schisandrae Chinensis 3-16 part, Herba Leonuri 2-8 part, Radix Ophiopogonis 2-8 part, Radix Aucklandiae 2-5 part.
3. the pharmaceutical composition of a kind of diabetes according to claim 1, is characterized in that these pharmaceutical composition parts by weight are counted: Radix Codonopsis 18 parts, the fresh Radix Rehmanniae 18, Cortex Cinnamomi 18 parts, Radix Aconiti Lateralis Preparata 18 parts, the raw Rhizoma Anemarrhenae 12 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leonuri 6 parts, Radix Ophiopogonis 6 parts, the Radix Aucklandiae 3 parts.
4. the preparation of the Chinese medicine composition according to any one of claim 1-3, is characterized in that, described preparation is oral formulations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, tablet, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is tablet.
7. preparation according to claim 6, is characterized in that, the preparation method of described tablet is: the medical material getting recipe quantity is mixed in proportion and adds 6-15 times of soak by water 0.5-3h, decocts 1-2 time, merges decoction liquor; Decoction liquor is concentrated into solid-liquid ratio 0.5-2, regulate determining alcohol to 60%-85% after adding ethanol, dark place leaves standstill 10-36h, filters, and reclaims ethanol, is concentrated into thick paste, density 1.2-1.5(40-60 DEG C), dry, pulverize 80 mesh sieves, for subsequent use;
Add adjuvant, 70% ethanol soft material, granule processed, dry, compress tablet coating, to obtain final product.
8. the preparation method of preparation according to claim 7, is characterized in that, described decocting time is 2h, adds 8 times of water, decocts number of times 2 times; Solid-liquid ratio is 1:1.5, determining alcohol 70%, standing 16h.
9. preparation according to claim 7, it is characterized in that, the adjuvant of preparing of described tablet is: one or more combinations in sucrose, lactose, mannitol, soluble starch, dextrin, stevioside, aspartame, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvidone, micropowder silica gel, magnesium stearate, Polyethylene Glycol, polyvinyl alcohol, Opadry.
10. the application of the Chinese medicine composition described in any one of claim 1-3 in preparation treatment yang-yin asthenia type diabetes medicine.
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| CN201510749059.5A CN105194295A (en) | 2015-11-08 | 2015-11-08 | Medicine composition for treating diabetes |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510749059.5A CN105194295A (en) | 2015-11-08 | 2015-11-08 | Medicine composition for treating diabetes |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641594A (en) * | 2016-01-15 | 2016-06-08 | 马树华 | Medicine for treating diabetes |
| CN105663831A (en) * | 2016-02-24 | 2016-06-15 | 长沙佰顺生物科技有限公司 | Medicine composition for treating diabetes mellitus |
| CN108384265A (en) * | 2018-02-07 | 2018-08-10 | 陕西科技大学 | A kind of method that Cortex Bulbus Allii prepares degradation material |
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| CN1772183A (en) * | 2005-10-22 | 2006-05-17 | 王万鹏 | Diabetes treating Chinese medicine |
| CN101284015A (en) * | 2008-05-05 | 2008-10-15 | 济南康众医药科技开发有限公司 | Medicine for treating diabetes and production method thereof |
| CN102552696A (en) * | 2010-12-30 | 2012-07-11 | 天津药物研究院 | Compound diabetes oral preparation and preparation method thereof |
| CN104771725A (en) * | 2015-03-17 | 2015-07-15 | 魏芹 | Deficiency cold type diabetes treatment medicine |
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2015
- 2015-11-08 CN CN201510749059.5A patent/CN105194295A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1772183A (en) * | 2005-10-22 | 2006-05-17 | 王万鹏 | Diabetes treating Chinese medicine |
| CN101284015A (en) * | 2008-05-05 | 2008-10-15 | 济南康众医药科技开发有限公司 | Medicine for treating diabetes and production method thereof |
| CN102552696A (en) * | 2010-12-30 | 2012-07-11 | 天津药物研究院 | Compound diabetes oral preparation and preparation method thereof |
| CN104771725A (en) * | 2015-03-17 | 2015-07-15 | 魏芹 | Deficiency cold type diabetes treatment medicine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641594A (en) * | 2016-01-15 | 2016-06-08 | 马树华 | Medicine for treating diabetes |
| CN105663831A (en) * | 2016-02-24 | 2016-06-15 | 长沙佰顺生物科技有限公司 | Medicine composition for treating diabetes mellitus |
| CN108384265A (en) * | 2018-02-07 | 2018-08-10 | 陕西科技大学 | A kind of method that Cortex Bulbus Allii prepares degradation material |
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