CN104771725A - Deficiency cold type diabetes treatment medicine - Google Patents

Abstract

The invention discloses a deficiency cold type diabetes treatment medicine. The deficiency cold type diabetes treatment medicine comprises 15-25 parts of aconite root, 5-15 parts of ginseng, 25-35 parts of Cornus officinalis, 25-35 parts of Radix Astragali, 5-15 parts of Fructus Evodiae, 10-20 parts of Radix Morindae officinalis, 25-35 parts of Malaytea Scurfpea Fruit, 15-25 parts of wolfberry fruit, 25-35 parts of prepared rehmannia roo, 10-20 parts of Radix Ophiopogonis, 10-20 parts of Poria cocos, 25-35 parts of Chinese yam, 5-15 parts of cinnamon, 5-15 parts of Chinese magnoliavine, 10-20 parts of ginger and 15-25 parts of honey-fried licorice root. The deficiency cold type diabetes treatment medicine has the efficacies of yin and kidney nourishing, kidney warming, yang invigorating and qi absorbing to kidney to make kidney yin sufficient, recover thunder and fire, reinforce kidney yang, invigorate Tu, rise yang, make qi sufficient and balance yang, has a good treatment effect on deficiency cold type diabetes, and can be vigorously popularized.

Description

A kind of medicine for the treatment of asthenic cold type diabetes

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of diabetes, be specifically related to a kind of medicine for the treatment of asthenic cold type diabetes.

Background technology

Now clinically, diabetics gets more and more, mainly be divided into syndrome of liver-stomach heat, Gastrointestinal excess heat, deficiency of the spleen and heat of the stomach, heat in the upper and cold in the lower, hyperactivity of fire caused by deficiency of YIN, deficiency of both QI and YIN, deficiency of both YIN and YANG seven type, Therapeutic Method is respectively: dissipating depression of QI heat clearing away, eliminating heat pathogen by purging the bowels, pungent drugs can disperse and bitter drugs can descend, cooling upper-JIAO and warming lower-JIAO, nourishing YIN to lower pathogenic fire, supplementing QI and nourishing YIN, tonifying both YIN and YANG are main, and wherein yang-yin asthenia type diabetes is asthenic cold type diabetes.

No matter be that type 1 diabetes or type 2 diabetes mellitus this kind of pattern of syndrome are much clinically, treatment asthenic cold type diabetes are existing clinical normal with the pieces of Jin ' gui shenqi pill for curing of tonifying both YIN and YANG, or only control glycemic therapeutic with insulin and oral medicine, but the more difficult control of blood glucose, clinical symptoms increases the weight of repeatedly, the complete exhaustion of islet function, and complication occurs serious, overall treatment effect is not good, brings considerable distress and financial burden to diabetics.

The kidney being the origin of congenital constitution, and ten thousand diseases are not controlled, ask in kidney; Kidney qi Yin bivacuity, deficiency of YIN affecting YANG, decline of the fire from the gate of life, not main warm, body fluid can not transpiration reach, therefore drinking water copiously; Without fire at the bottom of still, YANG failing to warm spleen-YANG, therefore eat and do not change, stomachache with cool feeling, anorexia vomiting; Kidney qi is lost in system bundle, therefore the urinary bladder being out of control; And kidney yin fictitious pole under, water is shallow does not support imperial thunder, therefore sees and mutually fire is run quickly, conjunctival congestion Hong heat.

Therefore, need a kind of medicine for the treatment of asthenic cold type diabetes clinical better to serve, for patient removes misery.

Summary of the invention

The present invention aims to provide and a kind ofly treats medicine of asthenic cold type diabetes and preparation method thereof, by selecting suitable medical material and proportioning thereof, reaches the effect of thoroughly curing asthenic cold type diabetes, safety and toxic and side effects is little.

In order to achieve the above object, the present invention is by the following technical solutions: a kind of medicine for the treatment of asthenic cold type diabetes, the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 15-25 part, Radix Ginseng 5-15 part, Fructus Corni 25-35 part, Radix Astragali 25-35 part, Fructus Evodiae 5-15 part, Radix Morindae Officinalis 10-20 part, Fructus Psoraleae 25-35 part, Fructus Lycii 15-25 part, Radix Rehmanniae Preparata 25-35 part, Radix Ophiopogonis 10-20 part, Poria 10-20 part, Rhizoma Dioscoreae 25-35 part, Cortex Cinnamomi 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Rhizoma Zingiberis Recens 10-20 part and Radix Glycyrrhizae Preparata 15-25 part forms.

As preferably, the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 20 parts, Radix Ginseng 10 parts, Fructus Corni 30 parts, the Radix Astragali 30 parts, Fructus Evodiae 10 parts, Radix Morindae Officinalis 15 parts, Fructus Psoraleae 30 parts, Fructus Lycii 20 parts, 30 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 15 parts, 15 parts, Poria, Rhizoma Dioscoreae 30 parts, Cortex Cinnamomi 10 parts, Fructus Schisandrae Chinensis 10 parts, 15 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 20 parts form.

As preferably, the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 22 parts, Radix Ginseng 8 parts, Fructus Corni 27 parts, the Radix Astragali 32 parts, Fructus Evodiae 9 parts, Radix Morindae Officinalis 12 parts, Fructus Psoraleae 29 parts, Fructus Lycii 18 parts, 32 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 14 parts, 11 parts, Poria, Rhizoma Dioscoreae 32 parts, Cortex Cinnamomi 12 parts, Fructus Schisandrae Chinensis 7 parts, 12 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 25 parts form.

As preferably, the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 17 parts, Radix Ginseng 12 parts, Fructus Corni 33 parts, the Radix Astragali 28 parts, Fructus Evodiae 13 parts, Radix Morindae Officinalis 18 parts, Fructus Psoraleae 35 parts, Fructus Lycii 23 parts, 28 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 18 parts, 16 parts, Poria, Rhizoma Dioscoreae 27 parts, Cortex Cinnamomi 8 parts, Fructus Schisandrae Chinensis 13 parts, 18 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 16 parts form.

As preferably, the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 21 parts, Radix Ginseng 9 parts, Fructus Corni 28 parts, the Radix Astragali 28 parts, Fructus Evodiae 9 parts, Radix Morindae Officinalis 13 parts, Fructus Psoraleae 28 parts, Fructus Lycii 22 parts, 28 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 13 parts, 13 parts, Poria, Rhizoma Dioscoreae 28 parts, Cortex Cinnamomi 8 parts, Fructus Schisandrae Chinensis 8 parts, 13 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 18 parts form.

Treat a preparation method for the medicine of asthenic cold type diabetes, comprise the steps:

Method one

By Radix Aconiti Lateralis Preparata, Radix Ginseng, Fructus Corni, the Radix Astragali, Fructus Evodiae, Radix Morindae Officinalis, Fructus Psoraleae, Fructus Lycii, Radix Rehmanniae Preparata, Radix Ophiopogonis, Poria, Rhizoma Dioscoreae, Cortex Cinnamomi, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata, first above-mentioned 16 taste Chinese crude drugs are added the soak by water twice of octuple amount, each two hours, collecting decoction, filter, filtrate reduced in volume to be relative density be 1.12 clear paste, this clear paste is added the ethanol of 90%-95%, stir, precipitate and reclaim ethanol and concentrate, dry at 45-50 DEG C, make dry clear paste, this dry clear paste is ground into fine powder, cross 100 mesh sieves, load No. 0 capsule.

Method two

By Radix Aconiti Lateralis Preparata, Radix Ginseng, Fructus Corni, the Radix Astragali, Fructus Evodiae, Radix Morindae Officinalis, Fructus Psoraleae, Fructus Lycii, Radix Rehmanniae Preparata, Radix Ophiopogonis, Poria, Rhizoma Dioscoreae, Cortex Cinnamomi, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata, above medicine is decocted to 400mL for subsequent use with water 3000mL.

The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:

Radix Aconiti Lateralis Preparata: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel.Effect: 1. recuperating depleted YANG and rescuing the patient from collapse, for yang depletion syndrome, disease sees cold spontaneous sweating, extremity cold of the limbs, faint pulse being about to disappear.The mainly exhaustion of YANG QI of kidney and the heart.This product can on help heart-yang to promote blood circulation, lower kidney-replenishing with benefit fire, save scatter and disappear Yuanyang, be " recuperating depleted YANG and rescuing the patient from collapse first product medicine ".Alone, strength is inadequate, normal and Rhizoma Zingiberis, the same use of Radix Glycyrrhizae, to strengthen effect of recuperating depleted YANG and rescuing the patient from collapse, i.e. and decoction for Resuscitation.Clinical yang-energy of often holding concurrently takes off, the QI prostration if sun declines, and dripping sweat, tachypnea dyspnea with rapid respiration person, at this moment only recuperating depleted YANG, do not have specific aim to vigour collapse, thus with the ginseng compatibility of strongly invigorating primordial QI, with recuperating the depleted YANG to cure collapse-syndrome as emergency treatment, i.e. shenfu decoction.2. mend fire supporing yang, mend fire, mend fire from the gater of life exactly, fire from the gater of life is exactly Yuanyang, the kidney yang of human body.For yang deficiency syndrome.This product can the sun of temperature the whole body, and all yang deficiency persons are as all in kidney, spleen, the heart dirty and to defend yang deficiency weak person all applicable.If insufficiency of kidney-YANG, insufficiency of kidney-YANG, decline of the fire from the gate of life, and see sexual impotence cold womb, fear of cold coldness of the body, chills and pain of the waist and kness, growth retardation, senilism; The not main water of kidney and edema, clear urine in large amounts, nocturia, bed wetter, is often equal to use with Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Corni, RUGUI Annex VIII taste ball.Kidney governing reproduction; Failure of the kidney in receiving QI, rapid breathing, goes out few, dyspnea due to deficiency more; The not warm spleen sun of kidney, deficiency of spleen-YANG and kidneyYANG, diarrhoea, incessant chronic diarrhea, deficiency of spleen-YANG and kidneyYANG, stops in aqueous vapor, sees dysuria, limbs edema person, helps the merit of yang transforming qi with it, is often equal to use, as Zhen Wu Tang, Decoction for strengthening the Spleen-Yang with the invigorating spleen for diuresis medicine Rhizoma Atractylodis Macrocephalae, Poria.Deficiency of heart-YANG, and see shortness of breath and palpitation, obstruction of qi in the chest and cardialgia person, can be equal to Radix Ginseng, Ramulus Cinnamomi and use.Defend the spontaneous perspiration due to yang insufficiency person of going out, can with the Radix Astragali, Ramulus Cinnamomi with using.But the most effectively improving can not warm body.Also have deficiency of spleen-YANG, the coldness and pain in the epigastrium of cold-damp accumulating in the interior, diarrhea, inappetence, its reinforce spleen and kidney together, normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the same use of Rhizoma Zingiberis, as cling conditions.Deficiency of heart-YANG, light spontaneous perspiration, cardiopalmus or thoracic obstruction pain, having cold elephant, also can use, and blood circulation promoting and blood stasis dispelling or the Cortex Cinnamomi of the warm heart, Ramulus Cinnamomi compatibility, in addition, Wei Yang is solid, from apogee sweating, reinstates with the Radix Astragali one.3. dispersing cold for relieving pain, can warming middle-JIAO, again can warming the meridian.Warming the interior cold expelling widely.Warming middle-JIAO, for cold syndrome of the stomach, Deficiency and coldness of spleen and stomach, the cold-evil also for excess syndrome is overweight, coldness and pain in the epigastrium; Warming the meridian, passages through which vital energy circulates catches cold, and the cold type of pain of appearance, has a headache available, is similar to the effect of the wind-damp dispelling of Aconitum carmichjaelii Debx. in addition, for rheumatism and arthritis, its wind-damp dispelling of yang deficiency of especially holding concurrently, dispersing cold for relieving pain, but wind-damp dispelling is not as Aconitum carmichjaelii Debx..As long as have, cold no matter deficiency and excess is all available.Excess syndrome is exactly warming the interior dispersing cold for relieving pain, and deficient syndrome is exactly warmly nourishing Yangqi.For arthralgia pain.

Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly: impairment caused by overstrain is deficient, food is told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the card of all qi-blood-body fluid deficiencies.

The Radix Astragali: sweet in the mouth slightly warm in nature.Return lung, spleen, liver, kidney channel.Invigorating QI to consolidate the body surface resistance, holder skin ulcer granulation promoting.Cure mainly the empty spontaneous perspiration of body, chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration.The life Radix Astragali, has effect of benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting, is applicable to spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle and does not burst or burst and the disease such as not hold back for a long time.

Radix Morindae Officinalis: have another name called bar halberd, Radix Morindae Officinalis.For the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Acrid in the mouth, sweet; Slightly warm in nature.Return kidney channel, Liver Channel.Function: reinforcing the kidney and supporting YANG; Bone and muscle strengthening; Expelling wind and removing dampness.Cure mainly: suffer from a deficiency of the kidney; Few abdomen cold type of pain; Incontinence of urine; Cold womb; Anemofrigid-damp arthralgia; Soreness of the waist and knees; Rheumatism limb gas.Radix Morindae Officinalis has kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling.Be mainly used in impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.Though this product is warm and not dry, though tonify without causing stagnation.Belong to the product of warming and recuperating the kidney-YANG, only for deficiency-cold syndrome.

Fructus Corni: sour in the mouth, puckery, slightly warm in nature.It is the common medicine nourished simply.As in the formula such as LIUWEI DIHUANG WAN, shenqi pill, Bolus as a Kidney-Yin-Tonic, Yougui Wan, the kidney-Yang-Reinforcing Bolus, there is Fructus Corni.Modern age, well-known doctor's Zhang Xichun was shown special preference to it, and using it as the medicine of emergency.He says: " Fructus Corni can restrain vigour, and astringent or styptic treatment for spontaneous sweating slippage, cheers up." and hold back healthy energy and do not hold back pathogen.Function cures mainly: liver and kidney tonifying, restrains astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination, and leukorrhagia stopping only collapses, hidroschesis.In addition also have promoting the production of body fluid to quench thirst, for soreness of waist and knee joint, dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating is collapsed.Interior-heat is quenched one's thirst.

Radix Rehmanniae Preparata: slightly warm in nature; Sweet in the mouth; Return liver, kidney channel.Effect is mainly used in enriching blood moist; Benefit essence fills out marrow.Cure mainly blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia; Leakage is collapsed incessantly; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath.

Radix Ophiopogonis: cold nature; Sweet in the mouth, micro-hardship; GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.

Poria: property is put down; Sweet in the mouth, light; GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.For: edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Rhizoma Dioscoreae: property is put down; Sweet in the mouth; Return spleen, lung, kidney channel.Effect: spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Cure mainly: diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula.Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can atherosclerosis.

Cortex Cinnamomi: extremely hot in nature; Acrid in the mouth, sweet; GUIXIN, liver,spleen,kidney warp.Effect: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For: sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.

Fructus Schisandrae Chinensis: warm in nature; Sour in the mouth, sweet; Return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Fructus Evodiae: nature and flavor: hot in nature, acrid in the mouth, hardship.Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache, colic, beriberi, dysmenorrhea, abdominal distention, vomiting acid regurgitation, aphtha.

Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Function: warming the kidney to invigorate YANG, improving inspiration by invigorating kidney-QI antidiarrheal.Cure mainly: sexual impotence, spermatorrhea, frequent micturition number, the cold pain of waist hip, cold diarrhea of suffering from a deficiency of the kidney, suffers from a deficiency of the kidney and breathes heavily.

Rhizoma Zingiberis Recens: hot in nature, acrid in the mouth.Return spleen, stomach, the heart, lung meridian.Effect: warming middle-JIAO, recuperating depleted YANG, warming the lung to resolve fluid-retention.Cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels; Separate the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.

Radix Glycyrrhizae Preparata: sweet is flat.GUIXIN, lung, spleen, stomach warp.Function with cure mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Fructus Lycii: sweet, flat, return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight; Application is used for the sweet flat matter profit of syndrome of yin deficiency of liver and kidney this product, and flat invigorating the liver and kidney, has strengthening by means of tonics effect, and all cards of all hepatic and renal YIN deficiency all can be applied.With controlling: 1. deficiency of the liver and kindey, the vertigo of blood and essence asthenia, visual deterioration, often join Flos Chrysanthemi, Radix Rehmanniae Preparata etc., as QIJU DIHUANG WAN (" doctor's level "); 2. the soreness of the waist and knees of the hepatic and renal YIN deficiency, seminal emission, often join Radix Rehmanniae, Radix Adenophorae (Radix Glehniae) etc., as YIGUANJIAN (" Xu Mingyi Lei "); 3. the deficiency of YIN is quenched one's thirst, and normal being equal to Radix Rehmanniae, Radix Ophiopogonis is used.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described: the effect of the prescription medicine in the present patent application: enriching yin and nourishing kidney, warming the kidney to invigorate YANG, improving inspiration by invigorating kidney-QI returns kidney to make kidney yin sufficient, and thunder fire is returned former, and Yuanyang must be consolidated, and the prosperous sun of soil rises, and gas foot sun is secret.Respond well to treatment asthenic cold type diabetes.

All kinds of asthenic cold type diabetics 1000 example is accepted for medical treatment through clinical, be divided into two groups at random, often organize 500 people, matched group conventional base is treated, Primary Care is the Primary Cares such as diet control, exercise therapy and diabetes education while, application sulphanylureas associating metformin is treated, and according to the consumption of blood sugar regulating medicine, applies insulin if desired and controls blood glucose.Observation group uses the treatment by Chinese herbs in the present patent application on the basis of Primary Care, namely takes the capsule in the present patent application specific embodiment 1, after taking 2 months, compares falling hypoglycemic curative effect:

Wherein, Therapeutic Effects of Blood Glucose standard is reduced: effective: after treatment, fasting glucose < 7.2mmol/L or blood glucose decline more than 30% before comparatively treating; Effective: the rear fasting glucose > 8.3mmol/L for the treatment of or blood glucose decline before comparatively treating and reaches 10%-30%; Invalid: after treatment, fasting glucose > 8.3mmol/L or blood glucose comparatively treat front decline less than 10%;

Improve insulin resistant criterion of therapeutical effect: effective: after treatment, SI, IAI improve more than 50%; Effective: after treatment, SI, IAI improve 20%-50%; Invalid: after treatment, SI, IAI improve less than 20%.

Reduce Therapeutic Effects of Blood Glucose to compare: matched group 500 example, effective 150 examples, effective 200 examples, invalid 150 examples, total effective rate 70.0%; Observation group 500 example, effective 256 examples, effective 209 examples, invalid 35 examples, total effective rate 93.0%;

Improve insulin resistant comparitive study: matched group 500 example, effective 147 examples of matched group, effective 210 examples, invalid 143 examples, total effective rate 71.4%; Observation group 500 example, effective 226 examples, effective 249 examples, invalid 25 examples, total effective rate 95.0%;

Clinical symptoms improvement is compared: matched group 500 example, effective 97 examples, effective 199 examples, invalid 204 examples, total effective rate 59.2%; Observation group 500 example, effective 261 examples, effective 178 examples, invalid 61 examples, total effective rate 87.8%.

From above data, the medicine of the present patent application is than the medicine used during Primary Care, at reduction Therapeutic Effects of Blood Glucose, improve and in insulin resistant curative effect and clinical symptoms improvement, to be all better than the treatment of present Clinical Basis, therefore a kind of diabetes of medicine to asthenic cold type for the treatment of asthenic cold type diabetes of the present patent application have good therapeutic effect, and medicinal should be widelyd popularize.

In the present patent application: qi as the commander of blood in side, sun is cloudy root, the pungent sweet large heat of Radix Aconiti Lateralis Preparata, the property of medicine is dry, property belongs to pure sun, walk and do not keep, current 12 warps, main GUIXIN, kidney, spleen three warp, on heart-yang can be helped to promote blood circulation, lower energy fonifying life-gate fire warming the kidney sun, warming the kidney water to disappear the moon with beneficial water, middle energy warming the spleen sun is with fortune of helping, large complement sun, nourishing renal yang to restrict excessive yin, it is the key medicine of warming the interior invigorating YANG simply, with Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens share, toxicity reduction can namely kill Radix Aconiti Lateralis Preparata poison, strengthen recuperating depleted YANG and rescuing the patient from collapse effect again, with Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni compatibility treatment insufficiency of kidney-YANG, life fire is on the decline, the disease of frequent micturition, with Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Poria, Radix Glycyrrhizae Preparata compatibility, the hypoactivity of spleen-YANG for the treatment of YANG failing to warm spleen-YANG, stomachache with cool feeling, the disease of diarrhea with loose stool, this taste medicine energy temperature holds up the yang-energy of congenital kidney, for monarch drug, Radix Ginseng, Radix Astragali strongly invigorating primordial QI, promoting the production of body fluid to quench thirst simultaneously, Radix Rehmanniae Preparata, Radix Ophiopogonis benefit essence fill out marrow, supplementing QI and nourishing YIN, prevent and treat a large amount of hot medicine consumption impairment of QI cloudy, Radix Morindae Officinalis, Fructus Corni, Fructus Psoraleae warming and recuperating the kidney-YANG, improving inspiration by invigorating kidney-QI antidiarrheal, Fructus Evodiae stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal, shares the merit of playing spleen benefiting and strengthen kidney stomach function regulating with Poria, Rhizoma Dioscoreae, trimethyl gallic acid convergence is cloudy, supplementing QI for promoting the production of body fluid, and the kidney invigorating is astringent or styptic treatment for spontaneous sweating, helps Fructus Corni to restrain vigour, with Radix Ophiopogonis with coordinating Radix Ginseng, Radix Aconiti Lateralis Preparata, with recuperating depleted YANG rescuing YIN, Cortex Cinnamomi mends supporing yang, the let the fire back to its origin of fire, has both strengthened the merit of Radix Aconiti Lateralis Preparata reinforcing the kidney and supporting YANG, and has drawn again the mutually fiery Gui Yuan run quickly, Radix Glycyrrhizae Preparata QI invigorating and in, coordinating the actions of various ingredients in a prescription.Full side's Yin-nourishing and Yang-supporting, improving inspiration by invigorating kidney-QI returns kidney to make kidney yin sufficient, and thunder fire is returned former, and gas foot sun is secret.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment;

Embodiment 1

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, first above-mentioned 16 taste Chinese crude drugs are added the soak by water twice of octuple amount, each two hours, collecting decoction, filter, filtrate reduced in volume to be relative density be 1.12 clear paste, this clear paste is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45-50 DEG C, make dry clear paste, this dry clear paste is ground into fine powder, cross 100 mesh sieves, load No. 0 capsule for subsequent use,

Grandson, man, 52 years old, mouth town, Laiwu City Laicheng district, Shandong Province, first visit on January 16 in 2013: find that blood glucose raises 10 months, now uses insulin (sweet Shu Lin 30R is 30u, late 20u early) to control blood glucose, disease is seen: become thin, weight loss 7 kilograms, weak, gastralgia and acid regurgitation saliva, anorexia, drinking water copiously, it is upper and lower that day drinks 6 hot water bottle hot water, frequent micturition, day 35-40 time, fear of cold women's head-ornaments Hong heat, the arteries and veins right side is fine, left heavy sliding thin.Routine urinalysis: sugar (4+), fasting glucose: 10.4mmol/L.Insulin continues use, and gives Yin-nourishing and Yang-supporting, let the fire back to its origin, and improving inspiration by invigorating kidney-QI returns this group decoction for the treatment of kidney.Every day 3 times, each 2-4 grain.January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take the 5th day beginning symptom in top to alleviate, when 1 month, symptom disappears substantially, blood glucose fluctuation when 2 months, and glucose in urine disappears, and tongue arteries and veins takes a turn for the better, and insulin dosage reduces, and symptom is fully recovered.

Embodiment 2

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, above medicine is decocted to 400mL with water 3000mL;

Lee, man, 72 years old, forest farm, the Laiwu City Huashan, Shandong Province, first visit on July 10 in 2013: find that blood glucose raises more than 9 years, now uses insulin (Novolin 30R early 26, late 20u) control blood glucose, disease is seen: lethargy, limbs fatigue, fear of cold, nocturia, eats and does not change, thirsty desire for hot drinks, conjunctival congestion Hong heat, diarrhea with loose stool, light red tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis: sugar (4+), fasting glucose: 9.4mmol/L.Insulin continues use, and gives Yin-nourishing and Yang-supporting, let the fire back to its origin, and improving inspiration by invigorating kidney-QI returns this decoction for the treatment of kidney.2 are divided by this decoction to take inferior to during meridian, every day 1 dose.January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take the 10th day beginning symptom in top to alleviate, when 40 days, symptom disappears substantially, blood glucose fluctuation when 2 months, and glucose in urine disappears, and insulin dosage reduces, and the mental status is good, and defecation is normal.

Embodiment 3

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, first above-mentioned 16 taste Chinese crude drugs are added the soak by water twice of octuple amount, each two hours, collecting decoction, filter, filtrate reduced in volume to be relative density be 1.12 clear paste, this clear paste is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45-50 DEG C, make dry clear paste, this dry clear paste is ground into fine powder, cross 100 mesh sieves, load No. 0 capsule for subsequent use,

Chen, female, 58 years old, Laiwu City high and new technology industrial development zone, Shandong Province, December in 2013 first visit on the 16th: find that blood glucose raises more than 11 years, now uses insulin (excellently to secrete woods 70/30 early 26, middle 6u, late 16u) add acarbose control blood glucose, disease is seen: complexion is gloomy, limbs fatigue, hands and feet being not warm, nocturia, thirsty desire for hot drinks, diarrhea with loose stool, light red tongue, tongue is white, deep-thready pulse.Routine urinalysis: sugar (3+), fasting glucose: 10.4mmol/L.Insulin and acarbose continue use, and give Yin-nourishing and Yang-supporting, let the fire back to its origin, and improving inspiration by invigorating kidney-QI returns this decoction for the treatment of kidney.Every day 3 times, each 2-4 grain, January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take top within the 6th day, to start the symptom such as weak and alleviate, when 40 days, symptom disappears substantially, still has nocturia 2 times, blood glucose fluctuation when 2 months, and glucose in urine disappears, and insulin dosage reduces, and symptom is fully recovered, and tongue arteries and veins takes a turn for the better.

Embodiment 4

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, above medicine is decocted to 400mL for subsequent use with water 3000mL;

Wang, man, 72 years old, Laiwu City Department of Office Affairs of Shandong Province, retirement, first visit on January 10 in 2014: find that blood glucose raises more than 9 years, now uses insulin (Novolin 30R early 26, late 20u) to add Metformin Extended-release Tablets and controls blood glucose, disease is seen: lethargy, becomes thin, limbs fatigue, fear of cold, hands and feet being not warm, nocturia, eats and does not change, stomachache with cool feeling, anorexia vomiting, thirsty desire for hot drinks, conjunctival congestion Hong heat, diarrhea with loose stool, light red tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis: sugar (2+), fasting glucose: 9.4mmol/L.Insulin and metformin continue use, and give Yin-nourishing and Yang-supporting, let the fire back to its origin, and improving inspiration by invigorating kidney-QI returns this decoction for the treatment of kidney.2 are divided to take inferior to during meridian, every day 1 dose.January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take the 7th day beginning symptom in top to alleviate, when 35 days, symptom disappears substantially, still occasionally has extremity fear of cold, blood glucose fluctuation when 2 months, and glucose in urine disappears, and insulin dosage reduces, and Metformin Extended-release Tablets is stopped using, and symptom is fully recovered, the improvement of tongue arteries and veins.

Embodiment 5

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, above medicine is decocted to 400mL for subsequent use with water 3000mL;

Zhang, man, 62 years old, Laiwu City Laicheng district, Shandong Province Gao Zhuan people from town, first visit on February 10 in 2014: find that blood glucose raises more than 7 years, existing NovoNorm adds metformin and controls blood glucose, disease is seen: limbs fatigue, hands and feet being not warm, nocturia, stomachache with cool feeling, anorexia vomiting, thirsty desire for hot drinks, conjunctival congestion Hong heat, diarrhea with loose stool, light red tongue, tongue is white, thready pulse.Routine urinalysis: sugar (1+), fasting glucose: 8.4mmol/L.NovoNorm continues use, and stop Metformin Extended-release Tablets, and give Yin-nourishing and Yang-supporting, let the fire back to its origin, improving inspiration by invigorating kidney-QI returns this decoction for the treatment of kidney; Divide 2 to take inferior to during meridian, every day 1 dose, January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take the 10th day beginning symptom in top to alleviate, when 45 days, symptom disappears substantially, and cold drinks and snachs of still occasionally receiving is had a stomachache, blood glucose fluctuation when 2 months, and glucose in urine disappears, and symptom is fully recovered, and tongue arteries and veins takes a turn for the better.

Embodiment 6

Radix Aconiti Lateralis Preparata 20g, Radix Ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, Fructus Evodiae 10g, Radix Morindae Officinalis 15g, Fructus Psoraleae 30g, Fructus Lycii 20g, Radix Rehmanniae Preparata 30g, Radix Ophiopogonis 15g, Poria 15g, Rhizoma Dioscoreae 30g, Cortex Cinnamomi 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Zingiberis Recens 15g, Radix Glycyrrhizae Preparata 20g, first above-mentioned 16 taste Chinese crude drugs are added the soak by water twice of octuple amount, each two hours, collecting decoction, filter, filtrate reduced in volume to be relative density be 1.12 clear paste, this clear paste is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45-50 DEG C, make dry clear paste, this dry clear paste is ground into fine powder, cross 100 mesh sieves, load No. 0 capsule for subsequent use,

Qi, man, 47 years old, Laiwu City rural credit cooperative of Shandong Province employee, first visit on July 10 in 2014: find that blood glucose raises more than 10 years, now use insulin (Novolin 30R early 30, late 26u) to add rosiglitazone and control blood glucose, disease is seen: lethargy, complexion is gloomy, becomes thin, limbs fatigue, hands and feet being not warm, nocturia, eats and does not change, stomachache with cool feeling, anorexia vomiting, thirsty desire for hot drinks, conjunctival congestion Hong heat, diarrhea with loose stool, light red tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis: sugar (2+), fasting glucose: 11.4mmol/L.Insulin and rosiglitazone continue use, and give Yin-nourishing and Yang-supporting, let the fire back to its origin, and improving inspiration by invigorating kidney-QI returns this decoction for the treatment of kidney, every day 3 times, each 2-4 grain, and January was 1 course for the treatment of, observed for 2 courses for the treatment of altogether.Take the 5th day beginning symptom in top to alleviate, when 35 days, symptom disappears substantially, still has fear of cold, nocturia 1-2 time, blood glucose fluctuation when 2 months, and health is good, and glucose in urine disappears, and insulin dosage reduces, and tongue arteries and veins takes a turn for the better.

Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.

Claims (7)

1. treat a medicine for asthenic cold type diabetes, it is characterized in that:

Medical material by following weight proportion: Radix Aconiti Lateralis Preparata 15-25 part, Radix Ginseng 5-15 part, Fructus Corni 25-35 part, Radix Astragali 25-35 part, Fructus Evodiae 5-15 part, Radix Morindae Officinalis 10-20 part, Fructus Psoraleae 25-35 part, Fructus Lycii 15-25 part, Radix Rehmanniae Preparata 25-35 part, Radix Ophiopogonis 10-20 part, Poria 10-20 part, Rhizoma Dioscoreae 25-35 part, Cortex Cinnamomi 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Rhizoma Zingiberis Recens 10-20 part and Radix Glycyrrhizae Preparata 15-25 part forms.

2. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Medical material by following weight proportion: the medical material by following weight proportion: Radix Aconiti Lateralis Preparata 20 parts, Radix Ginseng 10 parts, Fructus Corni 30 parts, the Radix Astragali 30 parts, Fructus Evodiae 10 parts, Radix Morindae Officinalis 15 parts, Fructus Psoraleae 30 parts, Fructus Lycii 20 parts, 30 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 15 parts, 15 parts, Poria, Rhizoma Dioscoreae 30 parts, Cortex Cinnamomi 10 parts, Fructus Schisandrae Chinensis 10 parts, 15 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 20 parts form.

3. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Medical material by following weight proportion: Radix Aconiti Lateralis Preparata 17 parts, Radix Ginseng 12 parts, Fructus Corni 33 parts, the Radix Astragali 28 parts, Fructus Evodiae 13 parts, Radix Morindae Officinalis 18 parts, Fructus Psoraleae 35 parts, Fructus Lycii 23 parts, 28 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 18 parts, 16 parts, Poria, Rhizoma Dioscoreae 27 parts, Cortex Cinnamomi 8 parts, Fructus Schisandrae Chinensis 13 parts, 18 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 16 parts form.

4. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Medical material by following weight proportion: Radix Aconiti Lateralis Preparata 21 parts, Radix Ginseng 9 parts, Fructus Corni 28 parts, the Radix Astragali 28 parts, Fructus Evodiae 9 parts, Radix Morindae Officinalis 13 parts, Fructus Psoraleae 28 parts, Fructus Lycii 22 parts, 28 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 13 parts, 13 parts, Poria, Rhizoma Dioscoreae 28 parts, Cortex Cinnamomi 8 parts, Fructus Schisandrae Chinensis 8 parts, 13 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 18 parts form.

5. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Radix Aconiti Lateralis Preparata 22 parts, Radix Ginseng 8 parts, Fructus Corni 27 parts, the Radix Astragali 32 parts, Fructus Evodiae 9 parts, Radix Morindae Officinalis 12 parts, Fructus Psoraleae 29 parts, Fructus Lycii 18 parts, 32 parts, Radix Rehmanniae Preparata, Radix Ophiopogonis 14 parts, 11 parts, Poria, Rhizoma Dioscoreae 32 parts, Cortex Cinnamomi 12 parts, Fructus Schisandrae Chinensis 7 parts, 12 parts, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata 25 parts composition.

6. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Its preparation method comprises the steps: Radix Aconiti Lateralis Preparata, Radix Ginseng, Fructus Corni, the Radix Astragali, Fructus Evodiae, Radix Morindae Officinalis, Fructus Psoraleae, Fructus Lycii, Radix Rehmanniae Preparata, Radix Ophiopogonis, Poria, Rhizoma Dioscoreae, Cortex Cinnamomi, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata, first above-mentioned 16 taste Chinese crude drugs are added the soak by water twice of octuple amount, each two hours, collecting decoction, filter, filtrate reduced in volume to be relative density be 1.12 clear paste, this clear paste is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45-50 DEG C, make dry clear paste, this dry clear paste is ground into fine powder, cross 100 mesh sieves, load No. 0 capsule.

7. a kind of medicine for the treatment of asthenic cold type diabetes according to claim 1, is characterized in that:

Its preparation method comprises the steps: that, by Radix Aconiti Lateralis Preparata, Radix Ginseng, Fructus Corni, the Radix Astragali, Fructus Evodiae, Radix Morindae Officinalis, Fructus Psoraleae, Fructus Lycii, Radix Rehmanniae Preparata, Radix Ophiopogonis, Poria, Rhizoma Dioscoreae, Cortex Cinnamomi, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens and Radix Glycyrrhizae Preparata, above medicine is decocted to 400mL for subsequent use with water 3000mL.