CN104771725B - A kind of drug for treating cold of insufficiency type patients with type Ⅰ DM - Google Patents
A kind of drug for treating cold of insufficiency type patients with type Ⅰ DM Download PDFInfo
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Abstract
The invention discloses a kind of drugs for treating cold of insufficiency type patients with type Ⅰ DM, are made of 15 25 parts of 15 25 parts of monkshood, 5 15 parts of ginseng, 25 35 parts of Fructus Corni, 25 35 parts of Radix Astragali, 5 15 parts of evodia rutaecarpa, 10 20 parts of Morinda officinalis, 25 35 parts of psoralea corylifolia, 15 25 parts of the fruit of Chinese wolfberry, 25 35 parts of radix rehmanniae preparata, 10 20 parts of Radix Ophiopogonis, 10 20 parts of Poria cocos, 25 35 parts of Chinese yam, 5 15 parts of Chinese cassia tree, 5 15 parts of Schisandra chinensis, 10 20 parts of ginger and honey-fried licorice root；With enriching yin and nourishing kidney, warming kidney and enhancing body, gas of receiving returns kidney to keep kidney yin sufficient, and thunder fire returns original, Yuanyang that must consolidate, and the prosperous sun of soil rises, and the secret effect of gas foot sun works well to treatment cold of insufficiency type patients with type Ⅰ DM, can vigorously promote the use.
Description
Technical field
The present invention relates to a kind of Chinese medicines for treating diabetes, and in particular to a kind of medicine for treating cold of insufficiency type patients with type Ⅰ DM
Object.
Background technology
Now clinically, diabetic is more and more, is broadly divided into syndrome of liver-stomach heat, Gastrointestinal excess heat, deficiency of the spleen and heat of the stomach, upper heat
Lower cold, fire excess from yin deficiency, deficiency of both qi and yin, yin-yang deficiency seven type, therapy are respectively：Open Yu Qingre, logical internal organs expels the heat-evil, Xin Kai
Bitter drop, cooling upper-JIAO and warming lower-JIAO, nourishing yin and lessening fire, supplementing qi and nourishing yin, based on tonifying both YIN and YANG, wherein yang-yin asthenia type diabetes are that asthenic cold type is sugared
Urine disease.
Clinically either such card type of type 1 diabetes or diabetes B is much, and treatment cold of insufficiency type patients with type Ⅰ DM is existing
It is clinical often to be treated with the chinkuei shin chewan pills of tonifying both YIN and YANG, or glycemic therapeutic is only controlled with insulin and oral medicine, but blood glucose compared with
Difficult to control, clinical symptoms aggravate repeatedly, the complete failure of islet function, and complication occurs seriously, and overall treatment effect is bad, to sugar
Urine patient brings considerable distress and financial burden.
The kidney being the origin of congenital constitution, ten thousand disease do not control, ask in kidney；Kidney qi Yin bivacuity, yin deficiency affecting yang, the Yang-function insufficiency of kidneyzang is not main warm,
Body fluid cannot reach in transpiration, therefore drink more；Bottom is eaten and is not changed without fire, the fiery not raw-soil, and stomachache with cool feeling, apocleisis is vomitted inverse；Kidney qi is lost
In system beam, therefore the urinary bladder being out of control；And fictitious pole is under for kidney yin, water is shallow not to support imperial thunder, therefore sees on mutually fire and run quickly, hot eyes Hong heat.
Therefore, it is necessary to a kind of drugs for treating cold of insufficiency type patients with type Ⅰ DM preferably to serve clinic, and pain is released for patient.
Invention content
The present invention is intended to provide a kind of drug and preparation method thereof for treating cold of insufficiency type patients with type Ⅰ DM, by selecting suitable medicine
Material and its proportioning achieve the effect that thoroughly to cure cold of insufficiency type patients with type Ⅰ DM, safety and toxic side effect is small.
In order to achieve the above object, the present invention uses following technical scheme：A kind of drug for treating cold of insufficiency type patients with type Ⅰ DM, by
The medicinal material of following weight proportion：15-25 parts of monkshood, 5-15 parts of ginseng, 25-35 parts of Fructus Corni, 25-35 parts of Radix Astragali, evodia rutaecarpa 5-
15 parts, 10-20 parts of Morinda officinalis, 25-35 parts of psoralea corylifolia, 15-25 parts of the fruit of Chinese wolfberry, 25-35 parts of radix rehmanniae preparata, Radix Ophiopogonis 10-20 part, Poria cocos
15-25 parts of 10-20 parts, 25-35 parts of Chinese yam, 5-15 parts of Chinese cassia tree, 5-15 parts of Schisandra chinensis, 10-20 parts of ginger and honey-fried licorice root form.
Preferably, by the medicinal material of following weight proportion：20 parts of monkshood, 10 parts of ginseng, 30 parts of Fructus Corni, 30 parts of Radix Astragali,
10 parts of evodia rutaecarpa, 15 parts of Morinda officinalis, 30 parts of psoralea corylifolia, 20 parts of the fruit of Chinese wolfberry, 30 parts of radix rehmanniae preparata, 15 parts of Radix Ophiopogonis, 15 parts of Poria cocos, Chinese yam 30
20 parts of part, 10 parts of Chinese cassia tree, 10 parts of Schisandra chinensis, 15 parts of ginger and honey-fried licorice root compositions.
Preferably, by the medicinal material of following weight proportion：22 parts of monkshood, 8 parts of ginseng, 27 parts of Fructus Corni, 32 parts of Radix Astragali, Wu
9 parts of the fruit of medicinal cornel, 12 parts of Morinda officinalis, 29 parts of psoralea corylifolia, 18 parts of the fruit of Chinese wolfberry, 32 parts of radix rehmanniae preparata, 14 parts of Radix Ophiopogonis, 11 parts of Poria cocos, 32 parts of Chinese yam,
25 parts of 12 parts of Chinese cassia tree, 7 parts of Schisandra chinensis, 12 parts of ginger and honey-fried licorice root compositions.
Preferably, by the medicinal material of following weight proportion：17 parts of monkshood, 12 parts of ginseng, 33 parts of Fructus Corni, 28 parts of Radix Astragali,
13 parts of evodia rutaecarpa, 18 parts of Morinda officinalis, 35 parts of psoralea corylifolia, 23 parts of the fruit of Chinese wolfberry, 28 parts of radix rehmanniae preparata, 18 parts of Radix Ophiopogonis, 16 parts of Poria cocos, Chinese yam 27
16 parts of part, 8 parts of Chinese cassia tree, 13 parts of Schisandra chinensis, 18 parts of ginger and honey-fried licorice root compositions.
Preferably, by the medicinal material of following weight proportion：21 parts of monkshood, 9 parts of ginseng, 28 parts of Fructus Corni, 28 parts of Radix Astragali, Wu
9 parts of the fruit of medicinal cornel, 13 parts of Morinda officinalis, 28 parts of psoralea corylifolia, 22 parts of the fruit of Chinese wolfberry, 28 parts of radix rehmanniae preparata, 13 parts of Radix Ophiopogonis, 13 parts of Poria cocos, 28 parts of Chinese yam,
18 parts of 8 parts of Chinese cassia tree, 8 parts of Schisandra chinensis, 13 parts of ginger and honey-fried licorice root compositions.
A kind of preparation method of drug that treating cold of insufficiency type patients with type Ⅰ DM, includes the following steps：
Method one
By monkshood, ginseng, Fructus Corni, Radix Astragali, evodia rutaecarpa, Morinda officinalis, psoralea corylifolia, the fruit of Chinese wolfberry, radix rehmanniae preparata, Radix Ophiopogonis, Poria cocos, mountain
Above-mentioned 16 taste Chinese medicine is first added the water of octuple amount to decoct twice by medicine, Chinese cassia tree, Schisandra chinensis, ginger and honey-fried licorice root, and two is small every time
When, collecting decoction, filtering, filtrate decompression concentration is the clear cream that relative density is 1.12, which is added to the second of 90%-95%
Alcohol, stirring, precipitation recycling ethyl alcohol simultaneously concentrate, dry at 45-50 DEG C, dry clear cream are made, this, which is done clear cream, is ground into fine powder, mistake
100 mesh sieve, and are packed into No. 0 capsule.
Method two
By monkshood, ginseng, Fructus Corni, Radix Astragali, evodia rutaecarpa, Morinda officinalis, psoralea corylifolia, the fruit of Chinese wolfberry, radix rehmanniae preparata, Radix Ophiopogonis, Poria cocos, mountain
Medicine, Chinese cassia tree, Schisandra chinensis, ginger and honey-fried licorice root, the above drug are decocted spare to 400mL with water 3000mL.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows：
Monkshood：It is pungent, sweet, big heat；It is toxic.It belongs to the heart, kidney, spleen channel.Effect：1. recuperating depleted yang is used for yang depletion syndrome symptoms include cold sweat
From going out, cold limbs, feeble and impalpable pulse.The mainly exhaustion of YANG QI of kidney and the heart.This product can on help heart-yang to promote blood circulation, lower kidney-replenishing is with benefit
Fire saves lost Yuanyang, is " the first product of recuperating depleted yang medicine ".It is applied alone, strength is inadequate, often with rhizoma zingiberis, Radix Glycyrrhizae with using, to reinforce
The effect of recuperating depleted yang, i.e. Sini Tang.Clinical often simultaneous yang-energy is de-, the qi exhaustion if sun declines, and sweats all over, shortness of breath asthma urgency person, at this moment
Only Hui Yang collapses no specific aim to vigour, so with the ginseng compatibility reinforced vital energy, with recuperating the depleted YANG to cure collapse-syndrome as emergency treatment, i.e. shenfu decoction.2. mending
Fire is supporing yang, mends fire, exactly mends fire from the gater of life, fire from the gater of life is exactly the Yuanyang of human body, kidney yang.For yang deficiency syndrome.This product can temperature one
The sun of body, all deficiency of yang persons are such as kidney, spleen, the heart are all dirty and defend deficiency of yang weak person is applicable in.If kidney-yang deficiency, the insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang, and
See impotence Gong Leng, chilly body is cold, waist and knee crymodynia, growth retardation, early ageing；The not main water of kidney and oedema, clear abundant urine, enuresis nocturna frequency
More, bed wetter is often equal with Chinese cassia tree, radix rehmanniae preparata, Fructus Corni and uses, such as osmanthus Annex VIII taste ball.Kidney governing reproduction；The failure of the kidney in receiving air is short of breath,
Go out mostly into few, void asthma；The not warm spleen sun of kidney, the insufficiency of both the spleen and the kindey, diarrhea, endless diarrhea, the insufficiency of both the spleen and the kindey stop in aqueous vapor, see urine not
Profit, limbs edema person, have the work(of helps yang transforming qi with it, are often equal with invigorating spleen for diuresis medicine Rhizoma Atractylodis Macrocephalae, Poria cocos and use, such as Zhen Wu Tang, Decoction for strengthening the Spleen-Yang.Heart-yang
Deficiency, and see palpitation, chest impediment and cardialgia person, it can be equal with ginseng, cassia twig and use.The spontaneous perspiration due to yang insufficiency person of going out is defended, it can be with Radix Astragali, cassia twig
With use.But it cannot warm body it is most useful that improving.It is also insufficiency of the spleen-yang, the coldness and pain in the epigastrium of cold-damp accumulating in the interior, diarrhea, appetite
It is depressed, its spleen kidney giving young employees remedial-courses in general knowledge and vocational skills, often with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, rhizoma zingiberis with using, such as monkshood lizhong decoction.Heart-yang is empty, light spontaneous perspiration, palpitaition or chest
Numbness pain, have it is cold as, it is also possible to and the Chinese cassia tree of the promoting blood circulation and removing blood stasis or warm heart, cassia twig compatibility, in addition, defending, sun is not solid, and spontaneous perspiration is not
Only, it is reinstated with Radix Astragali one.3. eliminating cold to stop pain, can middle benefit gas, and can Wen Jing.Cold dispelling in extensive temperature.Middle benefit gas is used for stomach cold, spleen
The stomach cold of insufficiency type, the cold-evil for being also used for real example is overweight, coldness and pain in the epigastrium；Wen Jing, passages through which vital energy circulates catch cold, and the crymodynia of appearance, headache are available, also class
It is similar to the effect of the wind-damp dispelling of the rhizome of Chinese monkshood, for rheumatism and arthritis, its wind-damp dispelling of the especially simultaneous deficiency of yang, eliminating cold to stop pain, but wind-damp dispelling
Not as good as the rhizome of Chinese monkshood.As long as having, cold no matter actual situation is available.Real example is exactly eliminating cold to stop pain in temperature, and the chronic diseases marked by deficiency of vital energy are exactly warmly nourishing Yangqi.For numbness
Bitterly.
Ginseng：Mild-natured, sweet in flavor, slight bitter, tepor.Returns spleen, lung channel.Effect：It reinforces vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, raw
Tianjin is quenched the thirst, tranquilize the mind and promote the intelligence.It cures mainly：Internal lesion caused by overexertion is deficient, deficiency of food, burnout, regurgitation and emesis, stool lingering diarrhea, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse,
Palpitation with fear forgetful, dizziness and headache, impotence, frequent micturition, is quenched one's thirst, woman uterine bleeding, infantile chronic fright and perennial and irrecoverable weakness, all qi-blood-body fluids are not
The card of foot.
Radix Astragali：Slightly warm in nature sweet in flavor.Return lung, spleen, liver and kidney channel.Invigorating qi for strengthening superficies, torr sore myogenic.Cure mainly physically weak spontaneous perspiration, chronic diarrhea,
Rectal prolapse, the prolapse of uterus, chronic nephritis, physically weak edema, chronic ulcer, the long disunion of the open sore part.Life Radix Astragali has invigorating qi for consolidating superficies, profit
The effect of water detumescence, detoxification, myogenic, suitable for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or bursts and does not hold back etc. diseases long.
Morinda officinalis：Also known as Morinda offcinalis How, RADIX MORINDAE OFFICINALIS.For the dry root of madder wort Morinda officinalis.Acrid flavour, it is sweet；Slightly warm in nature.Return kidney
Through, Liver Channel.Function：It tonifies the kidney and support yang；It strengthens muscles and bones；Dispelling wind and eliminating dampness.It cures mainly：Kidney deficiency；Few abdomen crymodynia；Urinary incontinence；Gong Leng；Chill
Arthritis with fixed pain caused by dampness；Soreness and weakness of waist and knees；Rheumatism limb gas.Morinda officinalis has kidney-replenishing, strengthening the bones and muscles, the effect of wind-damp dispelling.It is mainly used for impotence and seminal emission,
Uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence etc..Though this product is warm but not dry, though it mends without stagnant.Belong to temperature
The product of kidney-replenishing, are served only for asthenia cold syndrome.
Fructus Corni：It is sour, puckery, slightly warm in nature.It is the common medicine nourished simply.As Liuwei Dihuang Wan, shenqi pill, Zuogui Wan,
In the formulas such as Yougui Wan, the kidney-Yang-Reinforcing Bolus, there is Fructus Corni.Modern age name doctor Zhang Xichun shows special preference to it, and using it as the medicine of emergency.He
It says：" Fructus Corni can restrain vigour, and astringent method is slipped, cheered up." and healthy tendency is held back without holding back perverse trend.Major function：It tonifies the liver and kidney,
Astringent method, astringent sperm contracting urine are restrained, stop-band only collapses, hidroschesis.In addition there are promoting the production of body fluid to quench thirst, it to be used for soreness of waist and knee joint, dizziness and tinnitus, forgetful something lost
Smart involuntary emission, enuresis frequent micturition, irregular menstruation under uterine bleeding band, profuse sweating collapse.Heat Diabetes.
Radix rehmanniae preparata：Slightly warm in nature；It is sweet in flavor；Return liver and kidney channel.Effect is mainly used for enrich blood moist；Beneficial to spirit and marrow.The deficiency of blood is cured mainly to wither
It is yellow；Dizziness palpitaition；Irregular menstruation；Leakage is collapsed more than；Liver-kidney Yin deficiency；Hectic fever night sweat；Seminal emission impotence；Infertility；Soreness and weakness of waist and knees；Ear
Ring is deaf；It is dim-sighted；Poliosis；It quenches one's thirst；Constipation；Syndrome characterized by dyspnea.
Radix Ophiopogonis：Cold nature；It is sweet in flavor, slight bitter；The thoughts of returning home, lung, stomach.Effect：Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.It is dry for the dryness of the lung
Cough, tuberculosis cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines, pharyngeal diphtheria.
Poria cocos：It is mild-natured；It is sweet in flavor, light；The thoughts of returning home, lung, spleen, kidney channel.Effect：Eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.With
In：Oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Chinese yam：It is mild-natured；It is sweet in flavor；Returns spleen, lung, kidney channel.Effect：Tonifying spleen；Support lung；It reinforces the kidney；Strengthening the essence.It cures mainly：Splenasthenic diarrhea；Food
Few edema；Deficiency syndrome of the lung cough and asthma；It quenches one's thirst；Seminal emission；Under band；Kidney deficiency frequent micturition；Carbuncle swells are controlled in external application；Scrofula.《Compendium of Materia Medica》It records：" spring adopts
Wolfberry leaf, name day essence grass；Summer picks flowers, name houseleek；Qiu Caizi, the name fruit of Chinese wolfberry；Dong Caigen, the name root bark of Chinese wolf-berry ".Matrimony vine tender leaf is also known as
Matrimony vine head, edible or makees Chinese wolfberry tea.Modern study, the fruit of Chinese wolfberry have reduction blood glucose, lipotropy, and can anti-atherogenic
Hardening.
Chinese cassia tree：Extremely hot in nature；It is acrid flavour, sweet；The thoughts of returning home, liver,spleen,kidney warp.Effect：Mends fire supporing yang, let the fire back to its origin, eliminating cold to stop pain,
Invigorate blood circulation.For：Impotence, Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, dizziness due to yang deficiency, hot eyes pharyngalgia, trusted subordinate's crymodynia, the cold of insufficiency type are spat
It rushes down, cold hernia, run quickly globefish, Amenorrhea, dysmenorrhoea.
Schisandra chinensis：It is warm-natured；It is sour, sweet；Return lung, the heart, kidney channel.Effect：Restrain astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.For
Long-last cough and virtual asthma, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitaition
Insomnia.
Evodia rutaecarpa：Nature and flavor：Property heat, acrid flavour, hardship.Major function：Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For head
Bitterly, colic, tinea pedis, dysmenorrhoea, abdominal distention, vomiting acid regurgitation, aphtha.
Psoralea corylifolia：It is pungent, bitter, temperature.Return kidney, the spleen channel.Function：Warming kidney and enhancing body, receives gas antidiarrheal.It cures mainly：Impotence, involuntary emission, frequent micturition
Number, the cold pain of waist hip, kidney deficiency is cold to rush down, kidney deficiency asthma.
Ginger：Property heat, acrid flavour.Returns spleen, stomach, the heart, lung channel.Effect：Middle benefit gas, Hui Yang, warming lung and resolving fluid.Cure cold chill, vomits
It spits, phlegm and retained fluid is breathed with cough, turgor, diarrhea；Solve the tuber of pinellia, rhizoma arisaematis and ichthyophagy crab, birds and beasts meat poisoning.
Honey-fried licorice root：Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.Function with cure mainly：Tonifying spleen and stomach, Yiqi and vein recovery.It is weakness of the spleen and the stomach, it is tired
It is idle weak, severe palpilation, intermittent pulse.
The fruit of Chinese wolfberry：Sweet and neutral returns liver and kidney channel.Major function：It is nourishing liver and kidney, benefiting shrewd head；Using for syndrome of yin deficiency of liver and kidney
The sweet flat matter profit of this product, flat filling liver kidney have strengthening by means of tonics effect, all cards of the deficiency of liver-yin and kidney-yin that can apply.With controlling：1. kidney deficiency and liver,
The vertigo of blood and essence asthenia, hypopsia often match chrysanthemum, prepared rehmannia root etc., as Qiju Dihuang Wan (《Cure grade》)；2. the deficiency of liver-yin and kidney-yin
Soreness and weakness of waist and knees, seminal emission, often match glutinous rehmannia, the root of straight ladybell etc., as yiguan decoction (《Xu Mingyi Lei》)；3. the deficiency of Yin is quenched one's thirst, often with glutinous rehmannia, wheat
Winter is equally used.
The beneficial effects of the present invention will now be described with reference to clinical experimental data：The effect of group prescription in the present patent application：
Enriching yin and nourishing kidney, warming kidney and enhancing body, gas of receiving return kidney to keep kidney yin sufficient, and thunder fire returns original, Yuanyang that must consolidate, and the prosperous sun of soil rises, and gas foot sun is secret.To controlling
Cold of insufficiency type patients with type Ⅰ DM is treated to work well.
All kinds of cold of insufficiency type diabetes mellitus types 1000 are accepted for medical treatment through clinic, are randomly divided into two groups, and every group of 500 people, control group is normal
Primary Care is advised, Primary Care is while the Primary Cares such as diet control, exercise therapy and diabetes education, using sulfonylurea
Class joint melbine is treated, and the dosage of drug is adjusted according to blood glucose, applies insulin to control blood glucose when necessary.Observation group
It is treated, that is, taken in the present patent application specific embodiment 1 using the Chinese medicine in the present patent application on the basis of Primary Care
Capsule after taking 2 months, is compared the effect of reduction blood glucose：
Wherein, Therapeutic Effects of Blood Glucose standard is reduced：It is effective：Fasting blood-glucose ＜ 7.2mmol/L or blood glucose are relatively treated front lower after treatment
30% or more drop；Effectively：Fasting blood-glucose ＞ 8.3mmol/L or blood glucose decline before relatively treating after treatment reaches 10%-30%；In vain：
Fasting blood-glucose ＞ 8.3mmol/L or blood glucose decline before relatively treating less than 10% after treatment；
Improve insulin resistance criterion of therapeutical effect：It is effective：SI, IAI improve 50% or more after treatment；Effectively：SI after treatment,
IAI improves 20%-50%；In vain：SI, IAI are improved less than 20% after treatment.
Therapeutic Effects of Blood Glucose is reduced to compare：Control group 500, effective 150, effective 200, invalid 150, total effective rate
70.0%；Observation group 500, effective 256, effective 209, invalid 35, total effective rate 93.0%；
Improve insulin resistance curative effect to compare：Control group 500, effective 147 of control group, effective 210, invalid 143
Example, total effective rate 71.4%；Observation group 500, effective 226, effective 249, invalid 25, total effective rate 95.0%；
Clinical symptoms improvement is compared：Control group 500, effective 97, effective 199, invalid 204, total effective rate
59.2%；Observation group 500, effective 261, effective 178, invalid 61, total effective rate 87.8%.
From the above data, the drug of the present patent application is than the drug that is used when Primary Care, reduce Therapeutic Effects of Blood Glucose,
Better than present Clinical Basis is treated in terms of improving insulin resistance curative effect and clinical symptoms improvement, therefore the one of the present patent application
The drug that kind treats cold of insufficiency type patients with type Ⅰ DM has good therapeutic effect to the diabetes of asthenic cold type, should be pushed greatly on medicinal
Extensively.
In the present patent application：Qi as the commander of blood in side, sun are cloudy root, the pungent sweet big heat of monkshood, pharmacological property drying, and property belongs to pure sun, walks
Without keeping, current 12 warp, the main thoughts of returning home, kidney, spleen three pass through, on heart-yang can be helped to promote blood circulation, it is lower can fonifying life-gate fire warm up kidney yang, warm up kidney water with
Beneficial water disappears the moon, it is middle can warm spleen sun with fortune of helping, big complement sun, the source of beneficial fire, be it is warm simply in help the key medicine of sun, with honey-fried licorice root, life
Jiang Heyong, can toxicity reduction i.e. kill monkshood poison and recuperating depleted yang effect, controlled with Chinese cassia tree, radix rehmanniae preparata, the fruit of Chinese wolfberry, dogwood fruit compatibility
Treat the insufficiency of the kidney yang, on the decline, frequent micturition the disease of life fire, and ginseng, Radix Astragali, Chinese yam, Poria cocos, honey-fried licorice root compatibility, treatment fire not the raw-soil it
The disease of hypoactivity of spleen-YANG, stomachache with cool feeling, diarrhea with loose stool, this taste medicine energy temperature help the yang-energy of congenital kidney, are monarch drug in a prescription；Ginseng, Radix Astragali simultaneously
It reinforces vital energy, promote the production of body fluid to quench thirst；Radix rehmanniae preparata, Radix Ophiopogonis beneficial to spirit and marrow, supplementing qi and nourishing yin prevent a large amount of hot drug gas consumption impairment of yins；RADIX MORINDAE OFFICINALIS,
Fructus Corni, psoralea corylifolia warming and invigorating kidney Yang, gas antidiarrheal of receiving；Evodia rutaecarpa stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal share with Poria cocos, Chinese yam and play invigorating the spleen
The work(to reinforce the kidney with stomach；The convergence of Schisandra chinensis acid is cloudy, nourishing generate fluid, and kidney tonifying astringent method helps Fructus Corni to restrain vigour, coordinates with Radix Ophiopogonis same use
Ginseng, monkshood rescue the moon with Hui Yang；Chinese cassia tree mends fire supporing yang, let the fire back to its origin had not only enhanced the work(that monkshood is tonified the kidney and support yang, but also drew and run quickly it
Mutually fire Gui Yuan；Honey-fried licorice root QI invigorating is in, coordinating the drug actions of a prescription.Full side's Yin-nourishing and Yang-supporting, gas of receiving return kidney to keep kidney yin sufficient, and thunder fire returns original, gas
Foot sun is secret.
Specific implementation mode
In order to better understand with the implementation present invention, further illustrated the present invention with reference to specific embodiment；
Embodiment 1
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, first
The water of octuple amount is added to decoct twice above-mentioned 16 taste Chinese medicine, two hours every time, collecting decoction, filtering, filtrate decompression, which concentrates, was
The clear cream is added the ethyl alcohol of 90%-95% by the clear cream that relative density is 1.12, and stirring, precipitation recycling ethyl alcohol simultaneously concentrate, in 45-
It is dry at 50 DEG C, dry clear cream is made, this, which is done clear cream, is ground into fine powder, sieves with 100 mesh sieve, and it is spare to be packed into No. 0 capsule；
Sun, man, 52 years old, Shandong Province Laiwu City Laicheng district mouthful town, first visit on January 16 in 2013：It was found that blood glucose rise 10
A month, current insulin (sweet Shu Lin 30R morning 30u, late 20u) controlled blood glucose, symptoms include：It becomes thin, 7 kilograms of weight loss, weak, gastral cavity
Sour saliva of vomitting bitterly, apocleisis, drink is more, drinks 6 thermos bottle hot water or more day, urinates more, day 35-40 times, chilly head Hong heat, and the arteries and veins right side is micro-
Carefully, left heavy sliding thin.Routine urinalysis：Sugared (4+), fasting blood-glucose：10.4mmol/L.Insulin is after with and giving Yin-nourishing and Yang-supporting, ignite and return
Source, gas of receiving return this group of decoction for the treatment of kidney.3 times a day, 2-4 each.January is 1 course for the treatment of, observes 2 courses for the treatment of altogether.Take top the
Start symptom within 5 days to mitigate, symptom disappears substantially at 1 month, and blood glucose fluctuation at 2 months, glucose in urine disappears, and tongue vein improves, insulin
Dosage is reduced, symptom recovery from illness.
Embodiment 2
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, with
Upper drug is decocted with water 3000mL to 400mL；
Lee, man, 72 years old, Shandong Province Laiwu City Huashan forest farm, first visit on July 10 in 2013：It was found that blood glucose rise 9 years
It is remaining, current insulin (Novolin 30R early 26, late 20u) control blood glucose, symptoms include：It is apathetic, limbs fatigue, chilly, enuresis nocturna frequency
It is more, it eats and does not change, thirsty hot drink preference, hot eyes Hong heat, diarrhea with loose stool, pale tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis：Sugared (4+), it is empty
Abdomen blood glucose：9.4mmol/L.Insulin is after with and giving Yin-nourishing and Yang-supporting, let the fire back to its origin, gas of receiving returns this decoction for the treatment of kidney.By this soup
Agent point 2 is taken when being inferior to meridian, daily 1 dose.January is 1 course for the treatment of, observes 2 courses for the treatment of altogether.The 10th day beginning symptom in top is taken to subtract
Gently, 40 days when symptom disappear substantially, blood glucose fluctuation at 2 months, glucose in urine disappears, and insulin dosage is reduced, and the state of mind is good, greatly
Urine is normal.
Embodiment 3
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, first
The water of octuple amount is added to decoct twice above-mentioned 16 taste Chinese medicine, two hours every time, collecting decoction, filtering, filtrate decompression, which concentrates, was
The clear cream is added the ethyl alcohol of 90%-95% by the clear cream that relative density is 1.12, and stirring, precipitation recycling ethyl alcohol simultaneously concentrate, in 45-
It is dry at 50 DEG C, dry clear cream is made, this, which is done clear cream, is ground into fine powder, sieves with 100 mesh sieve, and it is spare to be packed into No. 0 capsule；
Chen, female, 58 years old, Shandong Province Laiwu City high and new technology industrial development zone, first visit on December 16 in 2013：It was found that blood glucose rise 11 years
Remaining, current insulin (excellent to secrete woods 70/30 early 26, middle 6u, late 16u) plus acarbose control blood glucose, symptoms include：Complexion is gloomy, and four
Limb is weak, hands and feet being not warm, night pollakiuria, and thirsty hot drink preference, diarrhea with loose stool, pale tongue, tongue is white, deep thready pulse.Routine urinalysis：Sugared (3+), it is empty
Abdomen blood glucose：10.4mmol/L.Insulin and acarbose are after with and giving Yin-nourishing and Yang-supporting, let the fire back to its origin, gas of receiving returns this prescription of kidney
Treatment.3 times a day, 2-4 each, January is 1 course for the treatment of, observes 2 courses for the treatment of altogether.Start the symptoms such as weak within the 6th day above taking to subtract
Gently, 40 days when symptom disappear substantially, blood glucose fluctuation when still having enuresis nocturna 2 times, 2 months, glucose in urine disappears, and insulin dosage is reduced, disease
Shape is fully recovered, and tongue vein improves.
Embodiment 4
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, with
Upper drug is decocted spare to 400mL with water 3000mL；
Mr. Wang, male, 72 years old, Laiwu City Department of Office Affairs of Shandong Province, retirement, first visit on January 10 in 2014：It was found that blood
Sugar increases more than 9 years, and current insulin (Novolin 30R early 26, late 20u) plus Metformin Extended-release Tablets control blood glucose, symptoms include：Spirit
It is dispirited, it becomes thin, limbs fatigue, chilly, hands and feet being not warm, night pollakiuria eats and do not change, stomachache with cool feeling, and apocleisis is vomitted inverse, thirsty happiness heat
Drink, hot eyes Hong heat, diarrhea with loose stool, pale tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis：Sugared (2+), fasting blood-glucose：9.4mmol/L.Pancreas
Island element and melbine are after with and giving Yin-nourishing and Yang-supporting, let the fire back to its origin, gas of receiving returns this decoction for the treatment of kidney.2 are divided to be taken when being inferior to meridian
With daily 1 dose.January is 1 course for the treatment of, observes 2 courses for the treatment of altogether.It takes top and starts within the 7th day symptom and mitigate, symptom disappears substantially at 35 days
It losing, still occasionally there is a four limbs chilly, blood glucose fluctuation at 2 months, glucose in urine disappears, and insulin dosage is reduced, and Metformin Extended-release Tablets deactivate,
Symptom is fully recovered, and tongue vein improves.
Embodiment 5
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, with
Upper drug is decocted spare to 400mL with water 3000mL；
Zhang, man, 62 years old, Shandong Province Laiwu City Laicheng district people from the towns Gao Zhuan, first visit on the 10th in 2 months in 2014：It was found that blood glucose liter
More than 7 years high, current NovoNorm adds melbine to control blood glucose, symptoms include：Limbs fatigue, hands and feet being not warm, night pollakiuria, gastral cavilty are cold
Bitterly, apocleisis is vomitted inverse, thirsty hot drink preference, and hot eyes Hong heat, diarrhea with loose stool, pale tongue, tongue is white, and arteries and veins is thin.Routine urinalysis：Sugared (1+), fasting blood-glucose：
8.4mmol/L.NovoNorm is after with stopping Metformin Extended-release Tablets, and give Yin-nourishing and Yang-supporting, let the fire back to its origin, gas of receiving returns this prescription of kidney
Treatment；2 are divided to be taken when being inferior to meridian, daily 1 dose, January is 1 course for the treatment of, observes 2 courses for the treatment of altogether.It takes top and starts symptom on the 10th day
Mitigate, symptom disappears substantially at 45 days, cold food of still occasionally receiving stomachache, and blood glucose fluctuation at 2 months, glucose in urine disappears, symptom recovery from illness, tongue
Arteries and veins improves.
Embodiment 6
Monkshood 20g, ginseng 10g, Fructus Corni 30g, Radix Astragali 30g, evodia rutaecarpa 10g, Morinda officinalis 15g, psoralea corylifolia 30g, matrimony vine
Sub- 20g, radix rehmanniae preparata 30g, Radix Ophiopogonis 15g, Poria cocos 15g, Chinese yam 30g, Chinese cassia tree 10g, Schisandra chinensis 10g, ginger 15g, honey-fried licorice root 20g, first
The water of octuple amount is added to decoct twice above-mentioned 16 taste Chinese medicine, two hours every time, collecting decoction, filtering, filtrate decompression, which concentrates, was
The clear cream is added the ethyl alcohol of 90%-95% by the clear cream that relative density is 1.12, and stirring, precipitation recycling ethyl alcohol simultaneously concentrate, in 45-
It is dry at 50 DEG C, dry clear cream is made, this, which is done clear cream, is ground into fine powder, sieves with 100 mesh sieve, and it is spare to be packed into No. 0 capsule；
Qi, man, 47 years old, Laiwu City rural credit cooperative of Shandong Province employee, first visit on July 10 in 2014：It was found that blood glucose liter
More than 10 years high, current insulin (Novolin 30R early 30, late 26u) plus Rosiglitazone control blood glucose, symptoms include：It is apathetic, complexion
It is gloomy, it becomes thin, limbs fatigue, hands and feet being not warm, night pollakiuria eats and do not change, stomachache with cool feeling, and apocleisis is vomitted inverse, thirsty hot drink preference, hot eyes
Hong heat, diarrhea with loose stool, pale tongue, tongue is white, deep,thready and forceless pulse.Routine urinalysis：Sugared (2+), fasting blood-glucose：11.4mmol/L.Insulin and
Rosiglitazone is after with and giving Yin-nourishing and Yang-supporting, let the fire back to its origin, gas of receiving returns this decoction for the treatment of kidney, 3 times a day, 2-4 each, January
For 1 course for the treatment of, 2 courses for the treatment of are observed altogether.It takes top and starts within the 5th day symptom and mitigate, symptom disappears substantially at 35 days, still there is chilly, night
Blood glucose fluctuation when urinating 1-2 times, 2 months, physical condition is good, and glucose in urine disappears, and insulin dosage is reduced, and tongue vein improves.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.Here all embodiments can not be exhaustive.It is every to belong to this hair
Row of the obvious changes or variations that bright technical solution is extended out still in protection scope of the present invention.
Claims (6)
1. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM, it is characterised in that：
By the medicinal material of following weight proportion：15-25 parts of monkshood, 5-15 parts of ginseng, 25-35 parts of Fructus Corni, 25-35 parts of Radix Astragali, Wu
5-15 parts of the fruit of medicinal cornel, 10-20 parts of Morinda officinalis, 25-35 parts of psoralea corylifolia, 15-25 parts of the fruit of Chinese wolfberry, 25-35 parts of radix rehmanniae preparata, Radix Ophiopogonis 10-20 part,
15-25 parts of 10-20 parts of Poria cocos, 25-35 parts of Chinese yam, 5-15 parts of Chinese cassia tree, 5-15 parts of Schisandra chinensis, 10-20 parts of ginger and honey-fried licorice root groups
At.
2. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM according to claim 1, it is characterised in that：
By the medicinal material of following weight proportion：By the medicinal material of following weight proportion：20 parts of monkshood, 10 parts of ginseng, 30 parts of Fructus Corni, Huang
30 parts of stilbene, 10 parts of evodia rutaecarpa, 15 parts of Morinda officinalis, 30 parts of psoralea corylifolia, 20 parts of the fruit of Chinese wolfberry, 30 parts of radix rehmanniae preparata, 15 parts of Radix Ophiopogonis, Poria cocos 15
20 parts of part, 30 parts of Chinese yam, 10 parts of Chinese cassia tree, 10 parts of Schisandra chinensis, 15 parts of ginger and honey-fried licorice root compositions.
3. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM according to claim 1, it is characterised in that：
By the medicinal material of following weight proportion：17 parts of monkshood, 12 parts of ginseng, 33 parts of Fructus Corni, 28 parts of Radix Astragali, evodia rutaecarpa 13 part, bar
18 parts of halberd day, 35 parts of psoralea corylifolia, 23 parts of the fruit of Chinese wolfberry, 28 parts of radix rehmanniae preparata, 18 parts of Radix Ophiopogonis, 16 parts of Poria cocos, 27 parts of Chinese yam, 8 parts of Chinese cassia tree, five
16 parts of 13 parts of taste, 18 parts of ginger and honey-fried licorice root compositions.
4. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM according to claim 1, it is characterised in that：
By the medicinal material of following weight proportion：21 parts of monkshood, 9 parts of ginseng, 28 parts of Fructus Corni, 28 parts of Radix Astragali, 9 parts of evodia rutaecarpa, Morinda offcinalis How
It 13 parts, 28 parts of psoralea corylifolia, 22 parts of the fruit of Chinese wolfberry, 28 parts of radix rehmanniae preparata, 13 parts of Radix Ophiopogonis, 13 parts of Poria cocos, 28 parts of Chinese yam, 8 parts of Chinese cassia tree, the five tastes
18 parts of 8 parts of son, 13 parts of ginger and honey-fried licorice root compositions.
5. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM according to claim 1, it is characterised in that：
22 parts of monkshood, 8 parts of ginseng, 27 parts of Fructus Corni, 32 parts of Radix Astragali, 9 parts of evodia rutaecarpa, 12 parts of Morinda officinalis, 29 parts of psoralea corylifolia, matrimony vine
18 parts of son, 32 parts of radix rehmanniae preparata, 14 parts of Radix Ophiopogonis, 11 parts of Poria cocos, 32 parts of Chinese yam, 12 parts of Chinese cassia tree, 7 parts of Schisandra chinensis, 12 parts of ginger and toast are sweet
25 parts of compositions of grass.
6. a kind of drug for treating cold of insufficiency type patients with type Ⅰ DM according to claim 1, it is characterised in that：
Preparation method includes the following steps：By monkshood, ginseng, Fructus Corni, Radix Astragali, evodia rutaecarpa, Morinda officinalis, psoralea corylifolia, matrimony vine
Above-mentioned 16 taste Chinese medicine is first added octuple amount by son, radix rehmanniae preparata, Radix Ophiopogonis, Poria cocos, Chinese yam, Chinese cassia tree, Schisandra chinensis, ginger and honey-fried licorice root
Water decocts twice, two hours every time, collecting decoction, filtering, and filtrate decompression concentration is the clear cream that relative density is 1.12, this is clear
Cream adds the ethyl alcohol of 90%-95%, and stirring, precipitation recycling ethyl alcohol simultaneously concentrate, dry at 45-50 DEG C, and dry clear cream is made, this is done
Clear cream is ground into fine powder, sieves with 100 mesh sieve, and is packed into No. 0 capsule.
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| CN105194342B (en) * | 2015-10-26 | 2018-10-23 | 冯天宁 | It is a kind of to treat Chinese medicine for treating diabetes composition |
| CN105194295A (en) * | 2015-11-08 | 2015-12-30 | 长沙佰顺生物科技有限公司 | Medicine composition for treating diabetes |
| CN106138696A (en) * | 2016-08-16 | 2016-11-23 | 安徽天乾健食品科技有限公司 | A kind of prescription treating asthenic cold type diabetes and preparation method thereof |
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| CN101121008A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines glutinous rehmannia, Chinese yam, and raspberry for qi-replenishing and treating diabetes |
| CN101862413A (en) * | 2010-07-09 | 2010-10-20 | 喇孝瑾 | Chinese medicinal preparation for treating type-2 diabetes and preparation method thereof |
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| CN101121008A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines glutinous rehmannia, Chinese yam, and raspberry for qi-replenishing and treating diabetes |
| CN101862413A (en) * | 2010-07-09 | 2010-10-20 | 喇孝瑾 | Chinese medicinal preparation for treating type-2 diabetes and preparation method thereof |
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| Title |
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| 辨证治疗糖尿病40例;潘志雄;《中国疗养医学》;19990531;第8卷(第5期);第41-42页，尤其是第41页1.2.2 * |
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