CN108714197A - A kind of digestion-promoting stomachic and preparation method thereof - Google Patents

A kind of digestion-promoting stomachic and preparation method thereof Download PDF

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Publication number
CN108714197A
CN108714197A CN201810942332.XA CN201810942332A CN108714197A CN 108714197 A CN108714197 A CN 108714197A CN 201810942332 A CN201810942332 A CN 201810942332A CN 108714197 A CN108714197 A CN 108714197A
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parts
weight
digestion
stomach
chinese medicine
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崔胜文
高鹏
高愿军
秦令祥
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Henan Sunset Blue Food Technology Co Ltd
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Henan Sunset Blue Food Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention discloses a kind of digestion-promoting stomachic and preparation method thereof, composition is as follows：Chinese medicine material 30-60%, excipient 40-70%, sweetener：0.2-0.3%.The present invention coordinates to see with unique recipe principle, the Overall View of integrated use Chinese medicine, and function of intestinal canal, strengthening the spleen and stomach are repaired in the side's of sending medication；Achieve the purpose that reparation with maintenance.

Description

A kind of digestion-promoting stomachic and preparation method thereof
Technical field
The present invention relates to a kind of rush to digest tcm product, more particularly, to a kind of digestion-promoting stomachic and preparation method thereof.
Background technology
It is weakness of the spleen and the stomach, it is traditional chinese medical term term.The weakness of the spleen and the stomach meaning is more general, contains Spleen-Qi Deficiency, insufficiency of the spleen-yang, spleen not The tcm syndromes such as system blood, the sinking of qi of middle-jiao, the stomach deficiency of yang, stomach Qi deficiency, stomach-Yin deficiency and deficiency-cold in spleen and stomach.Wherein Spleen-Qi Deficiency is weakness of the spleen and the stomach Fundamental type, syndrome of deficiency of spleen qi refer to deficiency of spleen-QI, lose the showed syndrome of its strong fortune.Mostly because of eating and drinking without temperance, overwork, prolonged illness Caused by wasting spleen-QI." Spleen-Qi Deficiency " word for《Interior warp》, such as《The Ling Shu Miraculous Pivot or Divine Axis natural span of life》Have in " 70 years old, Spleen-Qi Deficiency, skin It is withered " discussion.Thereafter ancient Chinese medicine doctor is furtherd investigate and is played to syndrome of deficiency of spleen qi, it is indicated that The spleen has the function to transport and transform nutrients, is qi and blood biochemistry Source is the foundation of acquired constitution.If native endowment is insufficient or ferritic is weakness of the spleen and the stomach；Or the day after tomorrow loses in maintenance or eating and drinking without temperance, famine is full to be lost Often or overstrain, it is worried with the passing of time, impairing the spleen and stomach；Or worn with age or serious disease, after prolonged illness, vigour is not multiple, loses in maintenance, Temper virtual loss can be made, transportation capabilities are not normal, lead to the biochemical weary source of qi and blood, form syndrome of deficiency of spleen qi.
With the quickening of social rhythm, the pressure of the various aspects such as life, study, work is all increasing, along with daily drink The various problems of food, the taste problem of modern become progressively more generally.The symptom the most often sent out is exactly stomach having indigestion indigestion. And diet is the unique channel for maintaining nutrient needed by human, can cause the various diseases of human body.
Application No. is CN201410494990.9 Chinese patents to disclose a kind of digestion-promoting stomachic, by the raw material of following parts by weight Composition：10-16 parts of ginseng, 10-20 parts of hawthorn, 8-12 parts of Radix Glycyrrhizae, 8-10 parts of the membrane of a chicken's gizzard, six 12-18 parts of songs, fig 8-12 Part, 10-16 parts of radish seed, 10-20 parts of malt, 10-16 parts of xylitol, 10-14 parts of honey, 30-50 parts of starch, 50-70 parts of water. The digestion-promoting stomachic can disperse accumulationization it is stagnant, spleen benefiting and stimulating the appetite and stomach are soothing the liver, have the effect of preferable regulating gastointestinal function.But Effect is not ideal enough.
Invention content
In view of this, in view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of digestion-promoting stomachic and its preparations Method, solves gastrointestinal function damage, and the bad problem of digestive function has achieved the effect that stomach invigorating, x help digestion and promoted digestion.
In order to achieve the above objectives, the present invention uses following technical scheme：
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 30-60%, excipient 40-70%, sweetener：0.2- 0.3%；
The Chinese medicine material is composed of the following raw materials in parts by weight：70-80 parts of radish seed, 60-70 parts of hawthorn, rhizoma cyperi 45- 55 parts, 45-55 parts of Rhizoma Chuanxiong, 60-70 parts of galangal, 45-55 parts of Fermented Soybean, 45-55 parts of Divine Comedy；35-45 parts of water chestnut, jujube 30- 40 parts, 30-40 parts of matrimony vine, 30-40 parts of walnut, 30-40 parts of ganoderma lucidum, 25-35 parts of pumpkin, 20-30 parts of mushroom；20-30 parts of chrysanthemum, 15-20 parts of Radix Salviae Miltiorrhizae, 10-20 parts of Centipeda minima, 10-20 parts of the root of Dahurain angelica；8-15 parts of sweet potato, black grape 8-15 parts, 5-10 parts of tendril-leaved fritillary bulb and 5-10 parts of Radix Glycyrrhizae；
The excipient is composed of the following raw materials in parts by weight：30-40 parts of starch, 15-20 parts of sodium carboxymethylcellulose, fish 10-15 parts of glue, 3-5 parts of lecithin.
The flavoring agent is：Mannitol, honey or white granulated sugar.
Preparation method includes the following steps：
One, the extraction of effective ingredient：Hawthorn is taken, walnut, pumpkin, sweet potato, black grape, peeled and cored, crushing are added 2-3 times of weight is squeezed the juice in the water of raw material；
Two, the extraction of effective ingredient：Radish seed, rhizoma cyperi, Rhizoma Chuanxiong, galangal, Fermented Soybean, Divine Comedy；Water chestnut, jujube, Matrimony vine, ganoderma lucidum, mushroom；Chrysanthemum, Radix Salviae Miltiorrhizae, Centipeda minima, the root of Dahurain angelica, tendril-leaved fritillary bulb and Radix Glycyrrhizae cleaning crush 2-3 times of parts by weight of addition The ethyl alcohol of 80-90% (v/v), refluxing extraction 30-50 minutes；Phegma and filter residue are detached, the water of 1-2 times of parts by weight is added in filter residue Ultrasonic extraction 30-50 minutes；It collects supernatant with phegma to merge, is condensed into saturated solution, be placed in freeze dryer dry；It must do Powder is spare；
In the ethyl alcohol 1-1.5% of ethyl alcohol mass fraction is accounted for added with the hydrochloric acid of 1mol/l, the hydrochloric acid.
Three, pellet processed：Dry powder obtained by step 2 is added in step 1 gained juice, excipient and seasoning is then added Agent is uniformly mixed；It is 15-35% to be condensed into water content mass fraction, and pellet is made；
Four, compression molding：Pellet obtained by step 3 is tabletted, it is dry；
Five, it is coated：Tablet after step 4 is dried is wrapped up with coating agent, and coated tablet is made；The coating agent is stomach Molten type coating agent, coating agent account for the 2-3% of drug gross weight.
The pharmacological effect of traditional Chinese medicinal components
Radish seed, meridian distribution of property and flavor：It is acrid flavour, sweet, it is mild-natured.Returns spleen, stomach, lung channel.Effect：Help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm.It is main It controls：For dyspeptic abdominal distention, weight after rush down dysentery, phlegm stops up cough and asthma.
Hawthorn, meridian distribution of property and flavor：Sour, sweet, micro-pungent, slightly warm in nature.Returns spleen, stomach, Liver Channel.Effect：1. promoting digestion and removing indigestion is used Meat stagnation is controlled, can be equal with radish seed, Divine Comedy and use.2. scattered stasis, with control the shouting pain of caused by energy stagnation and blood stasis side of body rib, blood stasis passes through It closes, can be equal with Rhizoma Chuanxiong, peach kernel, safflower and use；Postpartum stasis abdominal pain, lochiorrhagia are often equal with Radix Angelicae Sinensis, Rhizoma Chuanxiong, motherwort and use.
Rhizoma cyperi, meridian distribution of property and flavor：Acrid flavour, slight bitter, micro-sweet, it is mild-natured.Return liver, tri-jiao channel.Effect:Effect：Dispersing stagnated hepatoqi, Menstruction regulating and pain relieving.It cures mainly：For pain over the hypochondriac region, abdominal distention, hernia pain, irregular menstruation, swollen breasts.
Rhizoma Chuanxiong, meridian distribution of property and flavor：Acrid flavour, it is warm-natured；Return liver, courage, pericardium channel.1. blood-activating and qi-promoting of effect, with controlling hepatic depression Various pain cards caused by knot, traumatic injury, stagnation of blood stasis.Chest impediment and cardialgia, often with Radix Salviae Miltiorrhizae, radix paeoniae rubra with use；Side of body rib caused by stagnation of liver qi Have a pain, often with radix bupleuri, rhizoma cyperi with use；Amenorrhoea caused by stagnation of blood stasis, dysmenorrhoea are equally used with Radix Angelicae Sinensis, Radix Paeoniae Alba.2. wind-expelling pain-stopping is used The joint caused crymodynia of wind-cold-dampness arthralgia is controlled, is often equal with Radix Angelicae Pubescentis, turmeric, monkshood and uses.Headache belongs to chill person, often same with the root of Dahurain angelica, Jehol Ligusticum Rhizome With；Belong to wind-heat person, is often equal with fructus viticis, mulberry leaf and uses.
Galangal, meridian distribution of property and flavor:Acrid flavour, property heat.Returns spleen, stomach.Effect：Effect：Warm in pain.It cures mainly：For Coldness and pain in the epigastrium, vomiting and diarrhea.
Fermented Soybean, meridian distribution of property and flavor:Acrid flavour, slightly warm in nature.Channel tropism：It attaches to the lung and stomach meridians.Effect:Effect：Inducing diaphoresis, relieving restlessness.It is main It controls：For exterior syndrome due to wind-cold, dysphoria and insomnia
Divine Comedy, meridian distribution of property and flavor:It is sweet in flavor, pungent, it is warm-natured；Returns spleen, stomach.Effect:Effect：It helps digestion and stomach, antidiarrheal inducing diaphoresis. It cures mainly：Indigestion, abdominal fullness and distention and the gastrointestinal symptom caused by flu.
Water chestnut, meridian distribution of property and flavor:Hide it is sweet, it is cool in nature.Converge to the spleen channel, stomach.Effect:Effect：Invigorating spleen and reinforcing stomach, relieving thirst and restlessness, solution Poison.It cures mainly：Cure mainly splenasthenic diarrhea, hot summer weather polydipsia, insobriety, dysentery.
Jujube, meridian distribution of property and flavor：Sweet, warm.Returns spleen, stomach.Effect：Tonifying middle-Jiao and Qi, nourishing blood and tranquilization mitigate pharmacological property.It cures mainly：With In weakness of the spleen and the stomach, anorexia and loose stool, blood deficiency chlorosis, women's hysteria.
Matrimony vine, meridian distribution of property and flavor：It is sweet in flavor, it is mild-natured.Return liver and kidney channel.Effect：It is nourishing liver and kidney, benefiting shrewd head.
Walnut, meridian distribution of property and flavor：It is sweet in flavor, warm-natured, enter kidney, lung, large intestine channel.It cures mainly：Kidney deficiency asthma cough, pain in the back；Effect：1. blood-breaking Dissolving stasis：For amenorrhea due to stagnation of blood, abdominal pain due to blood stasis, store blood go mad, the bruise stasis of blood can etc. illnesss.2. moisturize laxation：For dry constipation of intestines Stool is difficult to resolve.This product hardship lets out the scattered stasis of blood, enters Liver Channel blood system, there is the work(of stronger promoting blood circulation for regulating menstruation, removing blood stasis for promoting tissue regeneration, be suitable for the blood system stasis of blood it is stagnant compared with Severe one.In addition, having the work(of ease constipation, cough-relieving concurrently.
Ganoderma lucidum, meridian distribution of property and flavor：Sweet-bitter flavor, mild-natured, the thoughts of returning home, lung, liver, the spleen channel；Effect：Can mental-tranquilization, support lung benefit Gas, Qi management and blood stasis, nourishing liver and spleen.It is weak to cure mainly consumptive disease, spiritlessness and weakness, palpitation and insomnia, the head swoons, and chronic cough asthma, appetite is not It shakes, slow in reacting, equal diseases short of breath.
Pumpkin, meridian distribution of property and flavor：It is warm-natured, sweet in flavor.Returns spleen, stomach.Effect：Tonifying middle-Jiao and Qi, anti-inflammatory analgetic, detoxify desinsection, drop Sugar.It cures mainly：1. removing toxic substances；2. protection gastric mucosa helps digest；3. preventing diabetes, reducing blood glucose；4. eliminating carcinogen；5. Enhancing development.
Mushroom, meridian distribution of property and flavor：It is sweet in flavor, it is mild-natured.Channel tropism：Intestines are returned to pass through, stomach, lung channel.Effect：Effect：Spleen benefiting and stimulating the appetite, The effect of soothing the liver is refreshed oneself.It cures mainly：It cures mainly diet not disappear, indigestion and loss of appetite, hypogalactia, vascular hypertension, god is tired to be slept.
Chrysanthemum, meridian distribution of property and flavor：Acrid flavour, sweet, bitter, cold nature；Return lung, Liver Channel.Effect：Effect：Dispelling wind and heat from the body clears liver Improving eyesight.It cures mainly：For syndrome of superficies attacked by wind-heat, warm disease is from the beginning of red eye, swell pain, mesh is secretly dim-sighted, vertigo.
Radix Salviae Miltiorrhizae, meridian distribution of property and flavor：Bitter, cold nature；The thoughts of returning home, pericardium, Liver Channel.Effect：1. invigorate blood circulation, with controlling stasis Amenorrhea, dysmenorrhoea and postpartum stasis of blood, can be applied alone this product to grind clothes.2. stasis-dispelling and pain-killing is with chest impediment and cardialgia is controlled, often with safflower, river Rhizome of chuanxiong, radix paeoniae rubra are equally used；Traumatic injury, hemostasis are had a pain, and are often equal with Radix Angelicae Sinensis, frankincense, myrrh and are used.3. cool blood detumescence：With controlling sore Carbuncle swells are often equal with honeysuckle, Fructus Forsythiae, the root of Dahurain angelica, radix paeoniae rubra and use；Beriberoid pyretic arthralgia is often equal with caulis lonicerae, radix paeoniae rubra, ramulus mori and uses.4. clear Heart relieving restlessness, dysphoria and insomnia caused by the mind is disturbed with heat is controlled, and is often equal with honeysuckle, Radix Ophiopogonis and is used.
Centipeda minima, meridian distribution of property and flavor：Acrid flavour, it is warm-natured.Return lung, Liver Channel.Effect：Expelling cold, eliminating, clearing the nasal passage, cough-relieving, Removing toxic substances.
The root of Dahurain angelica, meridian distribution of property and flavor：It is acrid flavour, warm-natured.It attaches to the lung and stomach meridians.Effect：Effect：Expelling cold and relieving exterior syndrome dispels pathogenic wind and remove dampness, and disappears Swollen apocenosis, analgesic.It cures mainly：For exterior syndrome due to wind-cold, have a headache, toothache, ulcerative carbuncle swelling and pain, morbid leucorrhoea duye.
Sweet potato, meridian distribution of property and flavor：It is mild-natured, sweet in flavor.Returns spleen, stomach, large intestine channel.Effect：Tonifying spleen benefit stomach, defaecation, nourishing generate fluid, profit Lung laxation.It cures mainly：Deficiency of spleen-QI and stomach-QI, malnutrition, puerpera, habitual constipation, constipation, chronic liver-kidney diseases, cancer, yctalopia.
Black grape, meridian distribution of property and flavor：It is mild-natured, it is sweet in flavor, sour.Return liver, lung, kidney channel.Effect：Fill blood liver and kidney benefiting, born fluid is strong Muscles and bones, relieving restlessness.It cures mainly：Ephritis, hypertension, edematous patient, children, pregnant woman, Anemic patients, neurasthenia, over fatigue, body are tired It is weak, prematurely senile, cough due to deficiency of the lung, night sweat.
Tendril-leaved fritillary bulb, meridian distribution of property and flavor：It is cool in nature, sweet taste；Enter lung channel, stomach.Effect：Moisten the lung and relieve the cough resolving sputum and relieving asthma, heat-clearing Resolving sputum.
Radix Glycyrrhizae, meridian distribution of property and flavor：It is sweet in flavor, it is mild-natured.The thoughts of returning home, spleen, lung, stomach.Effect：Effect：It invigorates the spleen and benefits qi, moistening lung stops Cough, it is clearing heat and detoxicating, alleviate analgesic, mitigates pharmacological property.It cures mainly：For weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, heat Carbuncle ulcer, medicine food poisoning, gastral cavity abdomen shoot, four limbs contraction pain.
The beneficial effects of the invention are as follows：
The present invention provides a kind of digestion-promoting stomachics and preparation method thereof.The present invention is with unique recipe principle, comprehensive fortune With the Overall View of Chinese medicine, coordinate to see, function of intestinal canal, strengthening the spleen and stomach are repaired in the side's of sending medication；Achieve the purpose that reparation with maintenance.
Radish seed, hawthorn digestingization product are reused in side, rhizoma cyperi, galangal dispersing stagnated hepatoqi, warm in pain are for monarch drug in a prescription；
It is helped digestion with Rhizoma Chuanxiong blood-activating and qi-promoting, Divine Comedy and stomach, antidiarrheal inducing diaphoresis, water chestnut invigorating spleen and reinforcing stomach, relieving thirst and restlessness, jujube blood-nourishing is pacified The effect of god, pumpkin anti-inflammatory analgetic, cooperative gain monarch drug in a prescription tonifying middle-Jiao and Qi, matrimony vine is nourishing liver and kidney, and walnut moisturize laxation, promoting blood circulation are dispelled The stasis of blood, mushroom spleen benefiting and stimulating the appetite, soothing the liver are refreshed oneself, sweet potato tonifying spleen benefit stomach, defaecation, nourishing generate fluid, moistening lung laxation, and black grape fills blood beneficial liver Kidney, born fluid strengthening the bones and muscles, relieving restlessness, tendril-leaved fritillary bulb moisten the lung and relieve the cough resolving sputum and relieving asthma as ministerial drug；
Lung QI invigorating is supported in Fermented Soybean inducing diaphoresis, relieving restlessness, ganoderma lucidum mental-tranquilization, and Qi management and blood stasis, nourishing liver and spleen are benefited ministerial drug invigorating the spleen and removed Tired, chrysanthemum spleen benefiting and stimulating the appetite, soothing the liver are refreshed oneself strong edema with the liver involved benefit spleen soil, Radix Salviae Miltiorrhizae invigorate blood circulation, Centipeda minima expelling cold, eliminating, clearing the nasal passage, in vain The root of Dahurian angelica dispels pathogenic wind and remove dampness, and help ministerial drug promotes the production of body fluid the effect of dry, is for adjutant；
It is to make medicine with Radix Glycyrrhizae, invigorates the spleen and benefits qi, moisten the lung and relieve the cough, it is clearing heat and detoxicating, alleviate analgesic, coordinating the drug actions of a prescription pharmacological property, priming is returned Through.
Dosage proportion in side：Radish seed：Chrysanthemum >=3.5；Galangal：Tendril-leaved fritillary bulb >=10.
The present invention is according to the pharmacodynamic profile of drug, and in conjunction with a large amount of practical experiences, the preparation method provided being capable of high efficiency extraction Effective ingredient, residual are few, easy to operate, easy to utilize.
Specific implementation mode
Embodiment 1
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 30%, excipient 69.8%, sweetener：0.2%；
The excipient is composed of the following raw materials in parts by weight：30 parts of starch, 15 parts of sodium carboxymethylcellulose, 10 parts of fish glue With 3 parts of lecithin；
The sweetener is：Mannitol；
The Chinese medicine material is composed of the following raw materials in parts by weight：70 parts of radish seed, 60 parts of hawthorn, 45 parts of rhizoma cyperi, Rhizoma Chuanxiong 45 parts, 60 parts of galangal, 45 parts of Fermented Soybean, 45 parts of Divine Comedy；35 parts of water chestnut, 30 parts of jujube, 30 parts of matrimony vine, 30 parts of walnut, ganoderma lucidum 30 parts, 25 parts of pumpkin, 20 parts of mushroom；20 parts of chrysanthemum, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of Centipeda minima, 10 parts of the root of Dahurain angelica；8 parts of sweet potato, black grape 8 parts, 5 parts of 5 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
Preparation method includes the following steps：
One, the extraction of effective ingredient：Hawthorn is taken, walnut, pumpkin, sweet potato, black grape, peeled and cored, crushing are added 2 times of weight are squeezed the juice in the water of raw material；
Two, the extraction of effective ingredient：Radish seed, rhizoma cyperi, Rhizoma Chuanxiong, galangal, Fermented Soybean, Divine Comedy；Water chestnut, jujube, Matrimony vine, ganoderma lucidum, mushroom；Chrysanthemum, Radix Salviae Miltiorrhizae, Centipeda minima, the root of Dahurain angelica, tendril-leaved fritillary bulb and Radix Glycyrrhizae cleaning crush the 80% of 2 times of parts by weight of addition (v/v) ethyl alcohol, refluxing extraction 30 minutes；Phegma and filter residue are detached, the water ultrasonic extraction 30 that 1 times of parts by weight is added in filter residue is divided Clock；It collects supernatant with phegma to merge, is condensed into saturated solution, be placed in freeze dryer dry；It is spare to obtain dry powder；The ethyl alcohol In added with 1mol/l hydrochloric acid, the hydrochloric acid accounts for the 1% of ethyl alcohol mass fraction；
Three, pellet processed：Dry powder obtained by step 2 is added in step 1 gained juice, excipient and seasoning is then added Agent is uniformly mixed；It is 15-35% to be condensed into water content mass fraction, and pellet is made；
Four, compression molding：Pellet obtained by step 3 is tabletted, it is dry；
Five, it is coated：Tablet after step 4 is dried is wrapped up with coating agent, and coated tablet is made；The coating agent is stomach Molten type coating agent, coating agent account for the 2% of drug gross weight.
Embodiment 2
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 60%, excipient 39.7%, sweetener：0.3%；
The excipient is composed of the following raw materials in parts by weight：40 parts of starch, 20 parts of sodium carboxymethylcellulose, fish glue 15 Part, 5 parts of lecithin；
The sweetener is：Honey.
The Chinese medicine material is composed of the following raw materials in parts by weight：80 parts of radish seed, 70 parts of hawthorn, 55 parts of rhizoma cyperi, Rhizoma Chuanxiong 55 parts, 70 parts of galangal, 55 parts of Fermented Soybean, 55 parts of Divine Comedy；45 parts of water chestnut, 40 parts of jujube, 40 parts of matrimony vine, 40 parts of walnut, ganoderma lucidum 40 parts, 35 parts of pumpkin, 30 parts of mushroom；22 parts of chrysanthemum, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Centipeda minima, 20 parts of the root of Dahurain angelica；15 parts of sweet potato, black Portugal 10 parts of 15 parts of grape, 7 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
Preparation method includes the following steps：
One, the extraction of effective ingredient：Hawthorn is taken, walnut, pumpkin, sweet potato, black grape, peeled and cored, crushing are added 3 times of weight are squeezed the juice in the water of raw material；
Two, the extraction of effective ingredient：Radish seed, rhizoma cyperi, Rhizoma Chuanxiong, galangal, Fermented Soybean, Divine Comedy；Water chestnut, jujube, Matrimony vine, ganoderma lucidum, mushroom；Chrysanthemum, Radix Salviae Miltiorrhizae, Centipeda minima, the root of Dahurain angelica, tendril-leaved fritillary bulb and Radix Glycyrrhizae cleaning crush the 90% of 3 times of parts by weight of addition (v/v) ethyl alcohol, refluxing extraction 50 minutes；Phegma and filter residue are detached, the water ultrasonic extraction 50 that 2 times of parts by weight are added in filter residue is divided Clock；It collects supernatant with phegma to merge, is condensed into saturated solution, be placed in freeze dryer dry；It is spare to obtain dry powder；The ethyl alcohol In added with 1mol/l hydrochloric acid, the hydrochloric acid accounts for the 1.5% of ethyl alcohol mass fraction；
Three, pellet processed：Dry powder obtained by step 2 is added in step 1 gained juice, excipient and seasoning is then added Agent is uniformly mixed；It is 35% to be condensed into water content mass fraction, and pellet is made；
Four, compression molding：Pellet obtained by step 3 is tabletted, it is dry；
Five, it is coated：Tablet after step 4 is dried is wrapped up with coating agent, and coated tablet is made；The coating agent is stomach Molten type coating agent, coating agent account for the 3% of drug gross weight.
Embodiment 3
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 45%, excipient 54.75%, sweetener：0.25%；
The excipient is composed of the following raw materials in parts by weight：35 parts of starch, 17 parts of sodium carboxymethylcellulose, fish glue 12 Part, 4 parts of lecithin；
The sweetener is white granulated sugar.
The Chinese medicine material is composed of the following raw materials in parts by weight：75 parts of radish seed, 65 parts of hawthorn, 50 parts of rhizoma cyperi, Rhizoma Chuanxiong 50 parts, 65 parts of galangal, 50 parts of Fermented Soybean, 50 parts of Divine Comedy；40 parts of water chestnut, 35 parts of jujube, 35 parts of matrimony vine, 35 parts of walnut, ganoderma lucidum 35 parts, 30 parts of pumpkin, 25 parts of mushroom；21 parts of chrysanthemum, 17 parts of Radix Salviae Miltiorrhizae, 15 parts of Centipeda minima, 15 parts of the root of Dahurain angelica；11 parts of sweet potato, black Portugal 8 parts of 12 parts of grape, 6 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
Preparation method includes the following steps：
One, the extraction of effective ingredient：Hawthorn is taken, walnut, pumpkin, sweet potato, black grape, peeled and cored, crushing are added 2.5 times of weight are squeezed the juice in the water of raw material；
Two, the extraction of effective ingredient：Radish seed, rhizoma cyperi, Rhizoma Chuanxiong, galangal, Fermented Soybean, Divine Comedy；Water chestnut, jujube, Matrimony vine, ganoderma lucidum, mushroom；Chrysanthemum, Radix Salviae Miltiorrhizae, Centipeda minima, the root of Dahurain angelica, tendril-leaved fritillary bulb and Radix Glycyrrhizae cleaning crush 2.5 times of parts by weight of addition The ethyl alcohol of 85% (v/v), refluxing extraction 40 minutes；Phegma and filter residue are detached, the water ultrasound that 1.5 times of parts by weight are added in filter residue carries It takes 40 minutes；It collects supernatant with phegma to merge, is condensed into saturated solution, be placed in freeze dryer dry；It is spare to obtain dry powder；Institute The hydrochloric acid added with 1mol/l in ethyl alcohol is stated, the hydrochloric acid accounts for the 1.2% of ethyl alcohol mass fraction；
Three, pellet processed：Dry powder obtained by step 2 is added in step 1 gained juice, excipient and seasoning is then added Agent is uniformly mixed；It is 25% to be condensed into water content mass fraction, and pellet is made；
Four, compression molding：Pellet obtained by step 3 is tabletted, it is dry；
Five, it is coated：Tablet after step 4 is dried is wrapped up with coating agent, and coated tablet is made；The coating agent is stomach Molten type coating agent, coating agent account for the 2.5% of drug gross weight.
Embodiment 4
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 50%, excipient 49.7%, sweetener：0.3%；
The Chinese medicine material is composed of the following raw materials in parts by weight：73 parts of radish seed, 63 parts of hawthorn, 41 parts of rhizoma cyperi, Rhizoma Chuanxiong 48 parts, 63 parts of galangal, 48 parts of Fermented Soybean, 48 parts of Divine Comedy；38 parts of water chestnut, 33 parts of jujube, 33 parts of matrimony vine, 33 parts of walnut, ganoderma lucidum 33 parts, 28 parts of pumpkin, 23 parts of mushroom；20 parts of chrysanthemum, 16 parts of Radix Salviae Miltiorrhizae, 13 parts of Centipeda minima, 13 parts of the root of Dahurain angelica；9 parts of sweet potato, black grape 10 parts, 6 parts of 5 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae；
The excipient is composed of the following raw materials in parts by weight：33 parts of starch, 16 parts of sodium carboxymethylcellulose, fish glue 11 Part, 3- parts of lecithin；
The sweetener is mannitol.
Preparation method is shown in embodiment 3.
Embodiment 5
A kind of digestion-promoting stomachic, composition are as follows：Chinese medicine material 58%, excipient 41.7%, sweetener：0.3%；
The Chinese medicine material is composed of the following raw materials in parts by weight：78 parts of radish seed, 68 parts of hawthorn, 52 parts of rhizoma cyperi, Rhizoma Chuanxiong 52 parts, 67 parts of galangal, 52 parts of Fermented Soybean, 52 parts of Divine Comedy；41 parts of water chestnut, 38 parts of jujube, 37 parts of matrimony vine, 37 parts of walnut, ganoderma lucidum 37 parts, 32 parts of pumpkin, 28 parts of mushroom；22 parts of chrysanthemum, 19 parts of Radix Salviae Miltiorrhizae, 18 parts of Centipeda minima, 18 parts of the root of Dahurain angelica；13 parts of sweet potato, black Portugal 9 parts of 13 parts of grape, 6 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae；
The excipient is composed of the following raw materials in parts by weight：38 parts of starch, 19 parts of sodium carboxymethylcellulose, fish glue 14 Part, 5 parts of lecithin；
The sweetener is honey.
Preparation method is shown in embodiment 3.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 3, the difference is that, galangal is 50 parts.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 3, the difference is that, chrysanthemum is 30 parts.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 3, the difference is that, delete the hydrochloric acid in step 2.
Drug effect is verified：
1. materials and methods：
The male Wistar rat of 1.1SPF8 week old 110, weight 180-220g；Grouping：110 Wistar rats It is randomly divided into embodiment 1-5 groups, control group 1-3 groups, blank control group, model group and Mosapride group, every group 10.Cage is raised In in the plastics cage of steel wire bottom, per 5, cage, every group of 2 cages.
1.2FD (functional dyspepsia FD) modelling：(Guo Haijun, Lin Jie, Lee state is at functional digestives for bibliography The combination of Chinese tradiational and Western medicine of undesirable Research of Animal Model for Study [J] China digests magazine, 2001,9 (3):141.) tail stimulus method is pressed from both sides, blank is removed Outside control group, at each group long sponge clamp rat tail distal end 1/3, it is degree with not broken skin, enables its violent rage, pick a quarrel big with other Mouse is beaten up to enrage full cage rat.Stimulation 30min every time, continuously stimulates in half an hour, with the aggravation fought, rat It may be scratched, to avoid inflammation from interfering, injury can be embrocated with 0.5% Iodophor, every 3h stimulations 1 time, 4 times a day, After continued stimulus 7d, there is nervous, anxiety reaction in rat, and food-intake significantly reduces, consistent with document report, show modeling at Work(.During modeling, rat ad lib, drinking-water are observed, are measured and records its general status daily.
Dosage refers to《Experimental zoology basis and technology》Using body surface area dosimetry, Mosapride group gives Mo Sha It must profit 1.35mg/kg；Various embodiments of the present invention and comparative example are swallowed with digestion-promoting stomachic, 10.4g/kg, blank control group and mould With respective volume physiological saline (10ml/kg), each group is administered daily 1 time type group.In addition to blank control group, every group after modeling It starts medication within 7th day, continued administration 14d.
1.3 materials and Indexs measure
Ordinary circumstance observes spirit, hair color and the stool of rat daily, measures the general feelings such as its weight, feed, amount of drinking water Condition.
Stomach residue rate and intestinal propulsion rate：It is deprived of food but not water after the last administration for 24 hours, gavage charcoal end semisolid pastes 1ml/ 100g, 30min pneumoretroperitoneum inject 10% chloraldurate, 0.35ml/100g.It is rapid to split abdominal cavity, stomach cardia and pylorus are ligatured, is taken Stomach is wiped with filter paper and claims full weight after doing, body of stomach is cut off along greater curvature side, and 4 DEG C of normal saline flushings remove gastric content, wipes dry, title stomach Net weight.Total small intestinal length (distance of pylorus to ileocecus) is surveyed, the distance that forward position is pasted from pylorus to charcoal end semisolid is charcoal end half The advance distance of solid pastes in the intestine.Y=a-bc × 100%, wherein y is Stomach residue rate, and a is stomach weight, and b is stomach net weight, and c is Gavage amount.Y=ab × 100%, wherein y is small intestine push ratio, and a is charcoal end advance distance (cm) in the intestine, and b is that small intestine is complete Long (cm).
HE is dyed：Clip antrum and jejunum epimere 5mm respectively2Each one piece is organized, normal saline flushing, in 4% poly 24-48h is fixed in formalin, then repair block, dehydration, bath it is transparent after, waxdip, embedding, slice, fishing piece, booth piece, then In 60 DEG C of drying boxes overnight, HE dyeing is carried out.
The detection clip antrum and jejunum epimere 5mm of SP, 5-HT, MTL index2Organize each one piece, normal saline flushing, Brain tissue is detached, is pinched with the elbow of disinfection and removes thalamus, -80 DEG C of refrigerators is placed in and preserves for use.Grinding, centrifuging and taking supernatant, according to ELISA kit specification operating procedure measures the content of SP, 5-HT, MTL in hypothalamus, SP, 5-HT and jejunum in antrum The content of epimere MTL.
1.4 statistical method
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Statistical analysis is carried out using SPSS17.0 softwares.Data indicate that multigroup is compared with mean ± standard deviation (x ± s) Compared with variance analysis, compares between two groups of means and examined with t, it is statistically significant as difference using 0.05 standards of P <.
2. result counts
2.1. stomach invigorating promotees digestion oral solution to rat gastric emptying rate and intestinal propulsion rate
Compared with blank control group, model group Stomach residue rate increases, and intestinal propulsion rate reduces (P < 0.05), Mosapride Group, embodiment 1-5 and comparative example 1-3 the groups Stomach residue rate compared with model group reduce, and intestinal propulsion rate increases, and difference has statistics Meaning (P < 0.05), the results showed that each embodiment and comparative example have facilitation to gastrointestinal motility, and effect is husky better than not It must sharp group.The Stomach residue rate of comparative example 1,2,3 reduces amplitude and the bright already clearly below embodiment 3 of intestinal propulsion rate elevation amplitude, table In bright change formula, the proportion of galangal and chrysanthemum, or change preparation method can influence medicine effect.It the results are shown in Table 1.
1 each group rat gastric emptying rate of table and impelling ratio
Group n Stomach residue rate (%) Intestinal propulsion rate (%)
Embodiment 1 10 56.15±11.83b 84.65±7.22b
Embodiment 2 10 56.08±11.73b 84.81±8.44b
Embodiment 3 10 56.01±10.71b 85.35±6.72b
Embodiment 4 10 56.45±110.63b 84.87±7.32b
Embodiment 5 10 56.65±12.73b 84.25±7.35b
Comparative example 1 10 66.75±13.63b 82.83±6.12b
Comparative example 2 10 67.65±12.81b 82.45±6.32b
Comparative example 3 10 57.37±11.95b 83.29±7.12b
Blank control group 10 55.49±121 81.92±6.03
Model group 10 75.40±6.45a 67.35±7.61a
Mosapride group 10 59.35±8.00b 82.87±4.77b
Note:Compared with blank control group,aP < 0.05；Compared with model group,bP < 0.05
2.2 digestion-promoting stomachics are to the influence to rat SP, 5-HT, MTL
In model group antrum tissue and hypothalamus in SP, 5-HT and small intestine the content of MTL compared with blank control group Apparent minimum (P < 0.01).Compared with model group, Mosapride group, embodiment 1-5 and comparative example 1-3 group antrum tissues and under The content of MTL is significantly raised (P < 0.01) in SP, 5-HT and small intestine in thalamus.And embodiment 1-5 groups are substantially better than not Sha Bili groups.Equally, in the group antrum tissue and hypothalamus of comparative example 1,2,3 in SP, 5-HT and small intestine MTL content Elevation amplitude is already clearly below embodiment 3, shows to change in formula, the proportion of galangal and chrysanthemum, or change preparation method are equal It can influence medicine effect.It the results are shown in Table 2, table 3.
In 2 each group Antrum tissue of table in SP, 5-HT and small intestine MTL content
Group n SP 5-HT MTL
Embodiment 1 10 364.21±68.03b 38.14±2.16b 318.21±26.15b
Embodiment 2 10 364.34±68.11b 37.86±2.28b 317.31±25.17b
Embodiment 3 10 365.14±68.07b 38.42±2.24b 318.51±26.17b
Embodiment 4 10 364.21±68.21b 37.34±2.14b 318.43±26.13b
Embodiment 5 10 364.04±68.12b 38.44±2.44b 317.47±26.22b
Comparative example 1 10 334.26±68.05b 34.62±2.12b 308.64±26.19b
Comparative example 2 10 332.27±66.22b 34.74±2.26b 308.21±24.11b
Comparative example 3 10 356.04±67.32b 36.54±2.34b 311.45±26.26b
Blank control group 10 366.08±65.54 39.86±2.46 333.20±24.56
Model group 10 207.58±48.81a 22.40±4.42a 144.60±36.76a
Mosapride group 10 341.87±76.79b 36.23±3.68b 312.64±40.26b
Note:Compared with blank control group,aP < 0.01；Compared with model group,bP < 0.01.
The content of SP, 5-HT, MTL in 3 each group rat hypothalamus of table
Group n SP 5-HT MTL
Embodiment 1 10 480.61±10.30b 47.96±1.61b 363.72±11.31b
Embodiment 2 10 480.82±11.36b 47.88±1.72b 364.78±11.16b
Embodiment 3 10 481.42±11.32b 48.11±1.42b 365.70±11.40b
Embodiment 4 10 480.71±11.30b 47.89±1.32b 364.66±11.33b
Embodiment 5 10 480.42±11.40b 47.85±1.52b 364.66±11.33b
Comparative example 1 10 450.50±11.20b 45.77±1.65b 332.56±11.23b
Comparative example 2 10 451.40±11.30b 45.27±1.72b 333.86±11.32b
Comparative example 3 10 465.70±11.40b 46.30±1.32b 350.76±11.36b
Blank control group 10 467.01±12.49 46.22±1.21 317.38±8.01
Model group 10 264.07±31.31a 23.35±1.42a 197.48±7.47a
Mosapride group 10 457.20±31.61b 46.66±1.63b 341.71±42.43b
Note:Compared with blank control group,aP < 0.01；Compared with model group,bP < 0.01.
Clinical drug effect：
By certain hospital's indigestion, having indigestion, abdominal pain, stomach hypofunction, defecate dry and astringent patient, screens 100, random point For treatment group and control group.Treatment group 50, wherein man 25, female 25；Age 186-70 Sui；- 18 years October of the course of disease.It takes Gained digestion-promoting stomachic of the invention, 3 times a day, each 3-5mg/ (3-5).Control group 50, wherein man 25, female 25, Age 16-70 Sui；- 16 years June of the course of disease.Certain commercially available brand digestion-promoting stomachic is taken, 3 times a day, dosage is followed the doctor's advice.Two groups have Comparativity.The 3-5 course for the treatment of counts curative effect later.Curative effect is relatively shown in Table 4.
The comparison (n) of 4. two groups of clinical efficacies of table
Group n Complete incidence graph Effectively In vain Total effective rate
Medication group 50 35 11 4 92%
Control group 50 15 25 10 80%
Finally illustrate, the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, this field is common Other modifications or equivalent replacement that technical staff makes technical scheme of the present invention, without departing from technical solution of the present invention Spirit and scope, be intended to be within the scope of the claims of the invention.

Claims (6)

1. a kind of digestion-promoting stomachic, which is characterized in that composition is as follows：Chinese medicine material 30-60%, excipient 40-70%, sweetener： 0.2-0.3%；
The Chinese medicine material is composed of the following raw materials in parts by weight：70-80 parts of radish seed, 60-70 parts of hawthorn, 45-55 parts of rhizoma cyperi, 45-55 parts of Rhizoma Chuanxiong, 60-70 parts of galangal, 45-55 parts of Fermented Soybean, 45-55 parts of Divine Comedy；35-45 parts of water chestnut, 30-40 parts of jujube, 30-40 parts of matrimony vine, 30-40 parts of walnut, 30-40 parts of ganoderma lucidum, 25-35 parts of pumpkin, 20-30 parts of mushroom；20-22 parts of chrysanthemum, Radix Salviae Miltiorrhizae 15-20 parts, 10-20 parts of Centipeda minima, 10-20 parts of the root of Dahurain angelica；8-15 parts of sweet potato, black grape 8-15 parts, 5-7 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae 5- 10 parts；
The excipient is composed of the following raw materials in parts by weight：30-40 parts of starch, 15-20 parts of sodium carboxymethylcellulose, fish glue 10-15 parts, 3-5 parts of lecithin；
The sweetener is：Mannitol, honey or white granulated sugar.
2. digestion-promoting stomachic according to claim 1, which is characterized in that the Chinese medicine material by following parts by weight raw material Composition：70 parts of radish seed, 60 parts of hawthorn, 45 parts of rhizoma cyperi, 45 parts of Rhizoma Chuanxiong, 60 parts of galangal, 45 parts of Fermented Soybean, 45 parts of Divine Comedy；Water chestnut 35 parts of angle, 30 parts of jujube, 30 parts of matrimony vine, 30 parts of walnut, 30 parts of ganoderma lucidum, 25 parts of pumpkin, 20 parts of mushroom；20 parts of chrysanthemum, Radix Salviae Miltiorrhizae 15 Part, 10 parts of Centipeda minima, 10 parts of the root of Dahurain angelica；5 parts of 8 parts of sweet potato, 8 parts of black grape, 5 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
3. digestion-promoting stomachic according to claim 1, which is characterized in that the Chinese medicine material by following parts by weight raw material Composition：80 parts of radish seed, 70 parts of hawthorn, 55 parts of rhizoma cyperi, 55 parts of Rhizoma Chuanxiong, 70 parts of galangal, 55 parts of Fermented Soybean, 55 parts of Divine Comedy；Water chestnut 45 parts of angle, 40 parts of jujube, 40 parts of matrimony vine, 40 parts of walnut, 40 parts of ganoderma lucidum, 35 parts of pumpkin, 30 parts of mushroom；22 parts of chrysanthemum, Radix Salviae Miltiorrhizae 20 Part, 20 parts of Centipeda minima, 20 parts of the root of Dahurain angelica；10 parts of 15 parts of sweet potato, 15 parts of black grape, 7 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
4. digestion-promoting stomachic according to claim 1, which is characterized in that the Chinese medicine material by following parts by weight raw material Composition：75 parts of radish seed, 65 parts of hawthorn, 50 parts of rhizoma cyperi, 50 parts of Rhizoma Chuanxiong, 65 parts of galangal, 50 parts of Fermented Soybean, 50 parts of Divine Comedy；Water chestnut 40 parts of angle, 35 parts of jujube, 35 parts of matrimony vine, 35 parts of walnut, 35 parts of ganoderma lucidum, 30 parts of pumpkin, 25 parts of mushroom；21 parts of chrysanthemum, Radix Salviae Miltiorrhizae 17 Part, 15 parts of Centipeda minima, 15 parts of the root of Dahurain angelica；8 parts of 11 parts of sweet potato, 12 parts of black grape, 6 parts of tendril-leaved fritillary bulb and Radix Glycyrrhizae.
5. a kind of preparation method according to any one of the claim 1-4 digestion-promoting stomachics, which is characterized in that including walking as follows Suddenly：
One, the extraction of effective ingredient：Hawthorn is taken, walnut, pumpkin, sweet potato, black grape, 2-3 is added in peeled and cored, crushing Times weight is squeezed the juice in the water of raw material；
Two, the extraction of effective ingredient：Radish seed, rhizoma cyperi, Rhizoma Chuanxiong, galangal, Fermented Soybean, Divine Comedy；Water chestnut, jujube, matrimony vine, Ganoderma lucidum, mushroom；Chrysanthemum, Radix Salviae Miltiorrhizae, Centipeda minima, the root of Dahurain angelica, tendril-leaved fritillary bulb and Radix Glycyrrhizae cleaning crush the 80-90% that 2-3 times of parts by weight are added （v/v）Ethyl alcohol, refluxing extraction 30-50 minutes；Phegma and filter residue are detached, the water ultrasound that 1-2 times of parts by weight are added in filter residue carries It takes 30-50 minutes；It collects supernatant with phegma to merge, is condensed into saturated solution, be placed in freeze dryer dry；It is standby to obtain dry powder With；
Three, pellet processed：Dry powder obtained by step 2 is added in step 1 gained juice, excipient and flavoring agent is then added, is mixed It closes uniform；It is 15-35% to be condensed into water content mass fraction, and pellet is made；
Four, compression molding：Pellet obtained by step 3 is tabletted, it is dry；
Five, it is coated：Tablet after step 4 is dried is wrapped up with coating agent, and coated tablet is made；The coating agent is stomach dissolution type Coating agent, coating agent account for the 2-3% of drug gross weight.
6. preparation method according to claim 5, which is characterized in that added with the salt of 1mol/l in ethyl alcohol described in step 2 Acid, the hydrochloric acid account for the 1-1.5% of ethyl alcohol mass fraction.
CN201810942332.XA 2018-08-17 2018-08-17 A kind of digestion-promoting stomachic and preparation method thereof Pending CN108714197A (en)

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CN103623296A (en) * 2013-12-03 2014-03-12 天津中新药业集团股份有限公司达仁堂制药厂 Preparation method of extract of traditional Chinese medicine with functions of regulating qi, relieving pain, invigorating stomach and promoting digestion
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