CN104225238A - Traditional Chinese medicine composition for curing diabetes - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for curing diabetes. The traditional Chinese medicine composition for curing diabetes comprises coptidis rhizoma, rhizoma polygonati, astragalus, atractylodes macrocephala, rhiizoma dioscoreae, radix trichosanthis, rhizoma anemarrhenae, fructus ligustri lucidi, schisandra chinensis, endothelium corneum gigeriae galli, radix cudramiae and wild ginseng and has the function of nourishing yin and producing sperm, reinforcing the vital essence and strengthening the primordial qi. The traditional Chinese medicine composition is used for curing diabetes and has the advantages of being targeted, fast in efficacy, short in medication use time and less in toxic and side effect.

Description

A kind of Chinese medicine composition for the treatment of diabetes

Technical field

The invention belongs to tcm field, relate to a kind of Chinese medicine composition for the treatment of diabetes.

Background technology

Diabetes are a kind of common endocrine metabolism diseases, it is the disease of the third-largest serious threat human health after tumor, vascular lesion, there is the feature of high fatality rate, high disability rate and high health care costs, become our times various countries common faced by public health problem.Though for many years through all multi-expert effort, also fail to capture this difficult problem.

The long term hyperglycemia state of diabetics can cause whole body Multisystem damage, causes various acute and chronic complication.Major chronic complication comprises cardiovascular disease, diabetic nephropathy, diabetic neuropathic pathological changes, diabetic foot and amputation, diabetic renal papillary necrosis etc.

At present, the diabetics of developed country more than 50% all accepts insulinize, and this ratio domestic is 11.1%.The result display of UKPDS research, diabetics can first from single oral antidiabetic drug treatment, then the oral antidiabetic drug merging other type of application is needed gradually, along with going down further and the deficiency of insulin secretion of islet beta cell function, reach the desirable target controlling blood glucose, most of needs of patients starts insulinize.In this regard, the multiple antidiabetic drug of doctor trained in Western medicine remains the of short duration method of curing the symptoms, not the disease, and draws the conclusion that doctor trained in Western medicine " controls for diabetes only, can not effect a radical cure " thus.

Diabetes are called " diabetes " by the traditional Chinese medical science, namely we often say more than three: polydipsia, polyphagia, polyuria." diabetes " this name of disease is just described in China's medical book Plain Questions of Huangdi's Internal Classic the earliest and Miraculous Pivot.It is due to deficiency-weakness of spleen-QI that "Nei Jing" has pointed out the truth diabetes, sinking of QI of middle-JIAO, lets out and form under causing sweet juice.Qing Dynasty Lin Peiqin also cloud in " class disease controls sanction " three disappears: " the not smelly anti-sweet person of urine, under its temper, de-disease is the heaviest." and then, the Republic of China well-known doctor Xie Liheng cloud again in " Chinese medicine voluminous dictionary " quenches one's thirst treatment 17: " the urine person that does sweet gas, de-under this temper, for disease is the heaviest." for the treatment of diabetes; the prescription be handed down ancient times is a lot; such as: dabuyin pill, LIUWEI DIHUANG WAN, Ginseng Baihu Decoction, SHENLING BAISHU SAN, XIAOYAO POWDER, dihuang drink, Taoren Chengqi Tang, BUYANG HUANWU TANG, YUQUAN WAN etc. are numerous; because formulation principle is very unclear; therefore have quality during administering therapeutic result, be difficult to promote.

Technology contents

Order of the present invention is to provide a kind of Chinese medicine composition for the treatment of diabetes, according to clinical, said composition distinguishes that disease is invented, have YIN nourishing spermatogenesis, vital base and primordial QI consolidating effect, for the treatment of diabetes, pointed strong, instant effect, administration time are short, the advantage of few toxic and side effects.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Treat a Chinese medicine composition for diabetes, it is characterized in that being made up of following Chinese medicine: Rhizoma Coptidis, Rhizoma Polygonati, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma dioscoreae, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Endothelium Corneum Gigeriae Galli, Radix Cudraniae, wild ginseng.

The present invention treats the Chinese medicine composition of diabetes, it is characterized in that the weight proportion of each Chinese medicine used is: Rhizoma Coptidis 15 parts, each 12 parts of Rhizoma Polygonati, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae 9 parts, Rhizoma dioscoreae 20 parts, Radix Trichosanthis 5 parts, the Rhizoma Anemarrhenae 9 parts, Fructus Ligustri Lucidi 11 parts, Fructus Schisandrae Chinensis 18 parts, Endothelium Corneum Gigeriae Galli 7 parts, Radix Cudraniae 5 parts, wild ginseng 22 parts.

The present invention treats the Chinese medicine composition of diabetes, and its preparation method is as follows:

According to both certainty ratios choose concoct after medicine, through pulverizing, sieving, then take Mel by medicated powder and Mel (1: 1), add water, put in pot to boil and endure slowly, by moisture content consumption to when dripping honey one-tenth pearl, cooling, add fine drug powder to stir evenly mediation and knead into honeyed pill, 1 gram, every ball, pack.Each 2, before the morning and evening 9 respectively once, warm water takes.

The Chinese medicine composition that the present invention treats diabetes with reference to plurality of medical pharmacopeia, is aided with the optimization of clinical application for many years simultaneously, overcomes the problem of taboo combination, specifically selects the pharmacological basis of Chinese medicine to be:

Rhizoma Coptidis, bitter in the mouth, cold in nature, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Rhizoma Polygonati, strengthening bone and muscle, beneficial marrow, mends vital essence; Treatment weakness of the spleen and stomach, fatigue and lack of strength.

The Radix Astragali, sweet in the mouth, slightly warm in nature.Return lung, spleen, liver, kidney channel.The Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, interior-heat is quenched one's thirst, chronic nephritis, diabetes etc.For invigorating the spleen and replenishing QI aspect.The disease such as unable as tired in weakness of the spleen and stomach, inappetence, anorexia and loose stool, limb, often uses together with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae; As collapse of QI, visceroptosis, as proctoptosis, gastroptosis etc., be often equal to use with Radix Codonopsis, Rhizoma Cimicifugae, Radix Bupleuri, side is as BUZHONG YIQI TANG.The Radix Astragali and Radix Ginseng all belong to QI invigorating good medicine, but Radix Ginseng biases toward strongly invigorating primordial QI.Radix Astragali tool and mending and oiliness feature, and if Radix Ginseng, the tonic compatibility then better effects if such as Radix Codonopsis.

The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

Rhizoma dioscoreae, sweet in the mouth, property is put down.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, heat-clearing and toxic substances removing.Cure mainly insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst.

Radix Trichosanthis, sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

The Rhizoma Anemarrhenae, bitter in the mouth, cold in nature.Enter lung, stomach, kidney channel.Nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Can be used for the deficiency of YIN to quench one's thirst, disease sees thirsty, drinking water copiously, frequent micturition person.This product has YIN nourishing to moisten bath, promoting the production of body fluid to quench thirst effect.Same Radix Trichosanthis, Fructus Schisandrae Chinensis etc. are with the use of heightening the effect of a treatment." herbal classic ": main quenching one's thirst is hankered, except pathogen limbs edema, lower water, tonifying for the deficiency, QI invigorating.

Fructus Ligustri Lucidi, sweet in the mouth, hardship, property is put down.Return liver, kidney channel; Tonic.Liver and kidney tonifying, clearind deficient heat, strong waist knee joint, improve visual and auditory acuity, black beard and hair.Can be used for controlling kidney by scorching, stranguria with turbid discharge is drowned bitterly, and waist foot is unable, disappears under being for a long time.

Fructus Schisandrae Chinensis, astringes the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.1. " herbal classic ": main QI invigorating, cough with dyspnea, the thin degree of impairment caused by overstrain, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence.2. " not Lu ": support the five internal organs, heat extraction, flesh in raw the moon.3. " Japan hanako materia medica ": improving eyesight, warming the kidney, controls wind, and the therapeutic method to keep the adverse QI flowing downwards helps digestion, cramp caused by acute vomiting and diarrhea, mass beside the umbilicus renal mass cold air, consumer edema, and regurgitation, trusted subordinate's flatulence, quenches the thirst, heat clearing away and restlessness relieving, alcoholic intoxication, strengthening bone and muscle.4. Li Gao: promoting the production of body fluid to quench thirst.Control dysentery, invigorating primordial QI is not enough, receives the gas of dissipation, platycoria.

Endothelium Corneum Gigeriae Galli, sweet in the mouth, property is put down.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach is aid digestion, arresting seminal emission.Can gastric secretion be promoted, improve gastric acidity and eupepsy, stomach motor function is obviously strengthened, rapid gastric emptying.

Radix Cudraniae, lightly seasoned micro-hardship, cool in nature.Expelling wind and removing dampness, promoting blood circulation to restore menstrual flow." east, Fujian book on Chinese herbal medicine ": invigorating spleen and reinforcing stomach, relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, blood stasis removing blood.Control lumbago, arthralgia, asthenia general edema with yellowish skin, diarrhea due to hypofunction of the spleen.

Wild ginseng, sweet in the mouth, micro-hardship, property is put down.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Modern medicine study confirms that wild ginseng is also improved vision and strengthens the scotopic effect of vision, and can improve diabetes patient's ordinary circumstance, senile diabetes patient glucose in urine can be made to reduce, blood glucose reduces 40%-50% milligram, still can maintain more than two weeks after drug withdrawal.After medium diabetes mellitus people takes, although it is not obvious to reduce blood glucose, overall health of patients makes moderate progress as the transference cure such as yearningly felt, weak or alleviate, and can reduce the effect of insulin, share also can treat various diseases with other drug.

The experiment of we's pharmaceutical composition non-clinical pharmacological animal, experimental program and result as follows:

1, experiment material

Wstar rat, male, body constitution 190 ~ 250g.Reference agent is alloxan, is SIGMA Products, and lot number B-12154, concentration is 50mg/ml.

2, experimental technique

After 20 Wistar Rat Fast 16h, lumbar injection alloxan 200mg/kg, 48h ophthalmic corner of the eyes venous plexus is taken a blood sample, serum blood glucose is surveyed with 7020 automatic biochemistry analyzers, except 2 death, 18 blood glucose values of Yuing are 22.7 ~ 46.5mmol/L, are into mould animal (blood glucose value >=16.05mmol/L).By blood glucose value height, divide equally in matched group and treatment group.Treatment group every day 2 times, the morning 7:30, afternoon, 1:30 gastric infusion, weighed weekly 1 time.Matched group is every only each to distilled water 10ml, and treatment group is often only each gives 2.44g crude drug/kg.Successive administration is fasting feedwater 16h after 2 weeks, and ophthalmic corner of the eyes venous plexus is taken a blood sample, and surveys serum blood glucose with 7020 automatic biochemistry analyzers.Result of the test adopts corresponding statistical method process, mortality rate x between two groups ²inspection, between two groups, mean significance compares and checks with t.

3, experimental result

Administration the 1st week, contrast and treatment group have no significant difference (table 1), all have animal dead (each 2) 1 weekend.Within 2nd week, control animals occurs that diet reduces, unable few dynamic, develops into stupor gradually, 4 death.The situation for the treatment of group animal is better. and amount of drinking water increases by 1 times, only has 1 animal to occur unable symptom, and within the 3rd week, matched group is all dead, and treatment group has 2 death in 3 weeks, through x ²inspection, P < 0.05.Alloxan diabetes rats, after this medicament composing prescription treats 2 weeks, compares with before self administration, and elevated blood glucose levels has remarkable reduction, and P < 0.01 compares P < 0.01 with matched group.In table 2.

Table 1 alloxan Oral Administration in Rats Chinese medicine composition curative effect of the present invention

Group	Number of animals	Body weight	48h blood glucose
				Matched group	9	165±13.3	43.1±6.7
Treatment group	9	174±14.2	41.3±6.2

Table 2 alloxan Oral Administration in Rats Chinese medicine composition of the present invention 2 weeks curative effects

Leading reference: [1] Song great Song, Kong Shunxian. diabetes treatment through spleen knows from experience [J]. Chinese Medicine journal, 2003,18 (10): 611; [2] Zhao Cuifang, Guan Song, Liu's copper bloom. from the importance and functions [J] of recur common cold tcm diagnosis and treatment diabetes. Beijing University of Chinese Medicine's journal, 2009,16 (3): 38; [3] Zhong Juan, Wei Lianbo, Longhai City's ripple. the Radix Astragali and active ingredient treatment diabetic nephropathy Recent Advances in Mechanism [J] thereof. packet header medical college journal, 2011,27 (5): 101; [4] Gao Meifeng, Huang Rong, Chen Yunfang. the extraction of astragalus polysaccharides and treatment diabetes pharmacological action progress [J] thereof. Liaoning University of TCM's journal, 2008,10 (6): 38; [5] Zhu Jiaying, Cen Xiaofeng etc. Rhizoma Coptidis alkaloid hypoglycemic activity synergism research [J]. time precious traditional Chinese medical science traditional Chinese medicines, 2010,21 (9): 2282; [6] Zuo Yaoming, Ye Shiling, Wan little Lan, etc. the extraction of. squash polyoses, analysis and blood sugar lowering experimentation [J]. Food Science, 2001,22 (12): 56; [7] Lu Shenghua, Sun Hongwei, Wang Juying, etc. Rhizoma anemarrhenae polysaccharide blood sugar reducing function and study mechanism [J] thereof. Chinese biochemical drug magazine, 2003,24 (2): 81; [8] Huang Fang, Xu Lihua, Guo Jianming, Chen Ting, etc. the blood sugar reducing function [J] of Rhizoma Anemarrhenae extract. Chinese biochemical drug magazine, 2005,26 (6): 332; [9] Liang Lei, limit Po Lam, Wang Hongjie. Chinese medicine blood-sugar decreasing active Recent Research [J]. Chinese experimental pharmacology of Chinese medical formulae magazine, 2010,17 (7): 227.

Clinical efficacy

1. sample information

Sample is clinical diabetes patient, effective 37 examples.Man 25 example wherein, female 12 example, age reckling 42 years old, the oldest person 65 years old.

2. Therapeutic Method

Each 2, the morning and evening 9 each 1 time before, warm water takes.30 days course for the treatment of, take 2 ~ 3 the course for the treatment of effect better.

3. therapeutic outcome

Use the various diabetes of this medicine composite for curing over several years, result shows this pharmaceutical composition for diabetics, evident in efficacy, clinical symptoms can be eliminated fast, take medicine 1 ~ 2 course for the treatment of, Western medicine and dependence product can be removed completely, do not need dietary restriction amount completely from start to finish.Take medicine 2 ~ 3 courses for the treatment of, clinical symptoms can be eliminated substantially, gets well.

4. model case

1, patient king so-and-so, man, 65 years old.Diabetes medical history 5 years, found xerostomia before 5 years, skin pruritus, and health check-up finds that fasting glucose is elevated to 9.7mmol/L, glycolated hemoglobin 7.7%, and post-prandial glycemia 9.8mmol/L, BMI:25, make a definite diagnosis diabetes.With Chinese medicine composition prescription of the present invention treatment, adhere to every day 2 times, each 2 honeyed pill.Such treatment is had a blood test after one month sugar again, on an empty stomach: 6.9mmol/L, after the meal: 7.9mmol/L.Again look into saccharifying and blood glucose after two months, on an empty stomach: 6.9mmol/L, after the meal: 7.7mmol/L, saccharifying: 6.6%.Glycemic control is good.After adhering to taking two first quarter moons, inspection in hospital, blood sugar level is normal, has recovered completely.Follow up a case by regular visits to so far, do not recur.

2, patient Lee, man, 54 years old.In April, 2008, Mr. Wang occurs that build is become thin, and normal sense is tired; Frequent micturition, excessive thirst, amount of drinking water increases, and appetite increases, and within 2 ~ 3 hours after the meal, namely feel hungry, sexual function sharply declines.Remove examination in hospital, blood pressure: 148/93mmHg, two pulmonary respiration sound is clear, does not hear and dry, moist rales, and border of cardiac dullness is without expansion, and heart rate 88 beats/min, hear sounds is low blunt, and the rhythm of the heart is neat, does not hear and noise.Touch too late under liver, spleen rib, two lower limb are without edema.Fasting glucose: 22.6mmol/L (normal value 3.9-6.1mmol/L), after the meal 2 hours blood glucoses: 26.5mmol/L (normal value 3.9-7.8mmol/L).Glucose in urine (+++) (normal glucose in urine is negative).Be diagnosed as diabetes.Hospitalization 3 months, effect is not desirable, seeks medical advice to here.Use our medicine 15, more than three, symptom is all eliminated, and treat after 2 months, health is got well substantially, vision, and libido function also recovers normal substantially, therapeutic process without insulin, also without Western medicine.

Specific embodiment

Get Rhizoma Coptidis 15 grams after concocting, each 12 grams of Rhizoma Polygonati, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae 9 grams, Rhizoma dioscoreae 20 grams, Radix Trichosanthis 5 grams, the Rhizoma Anemarrhenae 9 grams, Fructus Ligustri Lucidi 11 grams, Fructus Schisandrae Chinensis 18 grams, Endothelium Corneum Gigeriae Galli 7 grams, Radix Cudraniae 5 grams, wild ginseng 22 grams, pulverize, cross 100 mesh sieves.Take Mel 145 grams, add water 60 grams, put in pot to boil and endure slowly, by moisture content consumption to drip honey become pearl time, be cooled to 85 DEG C, add 145 grams of fine drug powders and stir evenly mediation and knead into honeyed pill, 1 gram, every ball, pack.

Take: each 2, the morning and evening 9 each 1 time before, warm water takes.30 days course for the treatment of, take 2 ~ 3 the course for the treatment of effect better.

Claims (2)

1. treat a Chinese medicine composition for diabetes, it is characterized in that being made up of following Chinese medicine: Rhizoma Coptidis, Rhizoma Polygonati, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma dioscoreae, Radix Trichosanthis, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Endothelium Corneum Gigeriae Galli, Radix Cudraniae, wild ginseng.

2. treat the Chinese medicine composition of diabetes as claimed in claim 1, it is characterized in that the weight proportion of selected each Chinese medicine is: Rhizoma Coptidis 15 parts, each 12 parts of Rhizoma Polygonati, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae 9 parts, Rhizoma dioscoreae 20 parts, Radix Trichosanthis 5 parts, the Rhizoma Anemarrhenae 9 parts, Fructus Ligustri Lucidi 11 parts, Fructus Schisandrae Chinensis 18 parts, Endothelium Corneum Gigeriae Galli 7 parts, Radix Cudraniae 5 parts, wild ginseng 22 parts.