CN103989938A - Chitosan composition for preventing and treating diabetes and preparation method of chitosan composition - Google Patents
Chitosan composition for preventing and treating diabetes and preparation method of chitosan composition Download PDFInfo
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Abstract
The invention discloses a chitosan composition for preventing and treating diabetes and a preparation method of the chitosan composition. The preparation method comprises the following steps: extracting puerarin, radix rehmanniae recen, bitter gourd, astragalus membranaceus, polygonatum odoratum and ganoderma lucidum to prepare dry paste powder, mixing the dry paste powder with sieved chitosan and starch, granulating, filling capsules, polishing and packaging to prepare the chitosan composition for preventing and treating diabetes. In the formula of the chitosan composition disclosed by the invention, the chitosan can promote internal secretion by regulating organ functions to regulate the pancreatic function, improve the activity of islet cells, so as to promote increased insulin secretion; such traditional Chinese medicinal materials in the formula as the puerarin, the radix rehmanniae recen, the bitter gourd, the astragalus membranaceus and the ganoderma lucidum are dialectically used to ensure functions of nourishing yin, engendering liquid and allaying thirst, moistening dryness and tonifying qi, and cooperatively condition human body organ functions with the chitosan so as to effectively prevent and treat diabetes and complication.
Description
Technical field
The invention belongs to medicines and health protection field, be specifically related to a kind of chitosan composite of preventing and treating diabetes and preparation method thereof.
Background technology
Diabetes are one of " three large killers " of threatening human life's health.China's diabetes present situation is very severe, and at first 10 years of 21 century, diabetes mellitus in China prevalence was turned over nearly twice.China is existing at present exceedes 9,400 ten thousand diabetics, and onset diabetes rate is up to 9.7%, and prediabetes patient reaches 1.46 hundred million, has become the fastest-rising country of global range diabetes, and surmounting India becomes the first in the world diabetes big country.Along with the continuous increase of China aged, urban population and the change of life style, diabetes prevalence is ascendant trend year by year, the diabetics newly increasing every year exceedes 1,200,000, approximately there are 3000 onset diabeticss every day, indivedual regional diabetes prevalences exceed 5%, wherein the ratio of 20～39 years old age bracket is that more than 3.9%, the 60 years old ratio in aging population is 20.4%, and the average prevalence of adult is 9.7%.And the increase of the raising of the rapid growth of diabetics number and China's quickening, living standards of the people of urbanization process over 10 years, unhealthy life style and city " affluenza " crowd that causes increases inseparable.Data show, China exceedes half diabetics and is attended by the metabolic diseases such as obesity, hypertension and blood fat disorder simultaneously, has greatly increased the risk that cardiovascular complication occurs.
" diabetes " are a kind of endocrine-metabolic diseases taking hyperglycemia as feature, insulin definitely or relative deficiency be the main cause that causes sugar, fat and protein metabolism disorder, polyuria, polydipsia, polyphagia, " three-many-one-little " symptom of becoming thin are its typical diseases.Once the blood glucose of diabetics is controlled the bad complication that just can cause, and causes the exhaustion pathological changes at the positions such as kidney, eye, foot, and cannot cure.On market, there is now the medicine of multiple treatment diabetes, Western medicine is taking blood sugar lowering as main, little to chronic complicating diseases of diabetes therapeutic effect, and owing to containing a lot of chemical analysis strong to human body toxic and side effects in Western medicine, liver, the injury of kidney of long-term taking to human body is serious.Compared with taking blood sugar lowering Western medicine, the damage that diabetics uses insulin can alleviate the organs and tissues such as human liver, kidney, but, not that each diabetes patient can use insulin, and, if insulin improper use easily produces hypoglycemia, what is more important, is used insulin and to take Western medicine the same, only has blood sugar reducing function, there is no therapeutic efficiency, diabetic complication is not had to obvious therapeutic effect.
Summary of the invention
The object of the present invention is to provide a kind of chitosan composite of preventing and treating diabetes and preparation method thereof, taking traditional Chinese medicine theory as basis, selecting Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma is primary raw material, after extracting, granulate with chitosan, starch, shape, make a kind of chitosan composite of preventing and treating diabetes, it can not only reduce blood glucose, and prevention effect that can also be unique to having of complication.
For achieving the above object, the present invention adopts following technical scheme:
Preventing and treating a chitosan composite for diabetes, is to be that primary raw material is prepared from by chitosan, Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma and starch.
In primary raw material, the mass percent of each component is as follows: chitosan 17-19%, and Radix Puerariae 14-16%, Radix Rehmanniae 12-14%, Fructus Momordicae charantiae 12-14%, Radix Astragali 12-14%, Rhizoma Polygonati Odorati 10-12%, Ganoderma 11%-13%, starch 4-6%, the mass percent sum of above-mentioned each component is 100%.
In primary raw material, the mass percent of each component is as follows: chitosan 18%, Radix Puerariae 15%, Radix Rehmanniae 13%, Fructus Momordicae charantiae 13%, the Radix Astragali 13%, Rhizoma Polygonati Odorati 11%, Ganoderma 12, starch 5%.
The preparation method of the described chitosan composite of preventing and treating diabetes, comprises the following steps:
(1) medical material dried cream powder preparation: the premenstrual processing of Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma that quality standard is up to the standards is put into extraction pot after cleaning, extracting in water 2 times, add for the first time the water of 10 times of quality of medicinal materials, first soak 1 hour, in extraction pot, pass into Steam Heating again, to 100 DEG C of beginning timing, decoct 2 hours, obtain extracting solution one time; Add for the second time the water of 8 times of quality of medicinal materials, decoct 1.5 hours, obtain secondary raffinate; Merge extracted twice liquid, extracting solution is filtered with 200 order silks, remove filtering residue, obtain filtrate; Filtrate is placed in to concentration tank, controls temperature at 60～80 DEG C, vacuum-0.04～-0.06MPa, being concentrated into and measuring relative density at 60 DEG C is to stop concentrating for 1.30 o'clock, obtains concentrated solution; Concentrated solution is carried out to vacuum drying, 60 DEG C of baking temperatures, vacuum-0.08MPa, is dried to moisture below 5%, obtains dry extract; With pulverizer, dry extract is pulverized, crossed 80 mesh sieves, the powder that gets dry extract, for subsequent use;
(2) sieving of chitosan, starch: chitosan, starch are crossed respectively 80 mesh sieves, for subsequent use;
(3) mixing granulation: dried cream powder and chitosan, starch are placed in to mixer mixing 30min, spray into mass fraction and be 95% alcoholic solution and prepare soft material, make soft material reach " that holds is agglomerating, gently pinches loose ", then fill 20 eye mesh screens with granulator and granulate; Wet granular is laid in basin, is dried to moisture below 5% at 60 DEG C; Dried granule is crossed to 20 eye mesh screens and carry out granulate, for subsequent use;
(4) capsule-filling: the granule making is delivered to capsule-filling chamber, by Autocapsulefillingmachine filling, capsule specification 450mg/ grain, content uniformity of regular check;
(5) capsule polishing, subpackage: after capsule-filling, with buffing machine, capsule is carried out to polishing, and sort out capsule off quality; Capsule is packed in Medical high-density vinyon bottle, 60/bottle, packaging.
Diabetes belong to " quenching one's thirst " category in the traditional Chinese medical science.The traditional Chinese medical science thinks, quench one's thirst refer to because of eating and drinking without temperance and disorder of emotion cause taking polydipsia, polyphagia, polyuria, emaciated physique or urinate the pleasantly sweet disease as feature, pathological changes internal organs are mainly dirty at lung, spleen (stomach), kidney three, especially attach most importance to stomach, it is scorching and taking the deficiency of YIN as this in the deficiency of YIN that its pathological change is mainly blamed, cloudy body fluid deficiency consumption, scorching monomania, the two is cause and effect mutually, the deficiency of YIN is scorching Sheng, and the scorching the moon of more containing more loses, and finally causes impairment of both QI and YIN, deficiency in both YIN and YANG, thus the deficiency of YIN scorching be main pathogenesis.Chinese medicine taking yin nourishing, moisturize, promote the production of body fluid, QI invigorating is as main, be aided with again activating blood and removing stasis drug, take good care of as main taking taste, the double Liver and kidney of taking good care of, to regulate metabolism of blood glucose function, dialectical treating, play altogether yin nourishing, promote the production of body fluid, quench the thirst, moisturize, effect of QI invigorating, play the effect of taking good care of internal organs function, not only can reach the object of auxiliary hyperglycemic, can also prevent and treat the generation of diabetic complication.
Chitosan in formula is a kind of macromolecule aminopolysaccharide, nonpoisonous and tasteless, has good biocompatibility, biodegradable, the advantage such as does not accumulate in vivo.There is research to think, because the bioadhesive of chitosan, alkalescence, positive charge etc. make it have good short Absorption to insulin, to improving the bioavailability important role of insulin.Fructus Momordicae charantiae is daily fruit and vegerable, summertime delicacies, has no side effect, and edible safety.Chinese medicine and pharmacy, Fructus Momordicae charantiae nature and flavor bitter cold, GUIXIN, stomach, spleen, Liver Channel, have cool, the hypoglycemic effect of heat clearing away solution.Radix Puerariae, Radix Rehmanniae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma are the conventional Chinese medicine of Chinese traditional treatment " diabetes ".Radix Puerariae is sweet, pungent, cool, returns spleen, stomach, lung meridian, has effect of promoting the production of body fluid to quench thirst.Radix Rehmanniae is sweet, cold, and GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, and effect of YIN nourishing and the production of body fluid promoting cures mainly interior-heat and quenches one's thirst.The Radix Astragali is sweet, tepor, returns lung, spleen channel, the effect of have tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting the production of body fluid and nourishing blood,, the disease such as gas drop, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat quench one's thirst weak for the deficiency of vital energy.Rhizoma Polygonati Odorati property is sweet, is slightly cold, and attaches to the lung and stomach meridians, and has effect of nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, for lung stomach-Yin wound, and the interior-heat disease such as quench one's thirst.Ganoderma property is sweet, flat, GUIXIN, lung, liver, kidney channel, have effect of invigorating QI and tranquilization, can be used for malaise, asthenia is losed heart.Above raw material is blood sugar lowering medicinal herbs most in use, and aboundresources is quality controllable, makes of fine qualities, the stable curative effect of chitosan composite of the present invention.
In addition, preparation method of the present invention is not only through groping to have adopted the most brief processing step, to reduce production costs, the aspects such as the operability, stability, quality controllability of production technology are also considered, the final concrete technology route of determining its preparation method is: extract → concentrated → vacuum drying → pulverize → sieve → mix → granulate → dry → granulate → total mixed → fillings → polishing → bottling → packaging, this technique simply, maturation, stablize controlled, automaticity is high.
Detailed description of the invention
Embodiment mono-
Preventing and treating a chitosan composite for diabetes, is to be that primary raw material is prepared from by chitosan, Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma and starch.
In primary raw material, the mass percent of each component is as follows: chitosan 18%, Radix Puerariae 15%, Radix Rehmanniae 13%, Fructus Momordicae charantiae 13%, the Radix Astragali 13%, Rhizoma Polygonati Odorati 11%, Ganoderma 12, starch 5%.
The preparation method of the described chitosan composite of preventing and treating diabetes, comprises the following steps:
(1) medical material dried cream powder preparation: the premenstrual processing of Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma that quality standard is up to the standards is put into extraction pot after cleaning, extracting in water 2 times, add for the first time the water of 10 times of quality of medicinal materials, first soak 1 hour, in extraction pot, pass into Steam Heating again, to 100 DEG C of beginning timing, decoct 2 hours, obtain extracting solution one time; Add for the second time the water of 8 times of quality of medicinal materials, decoct 1.5 hours, obtain secondary raffinate; Merge extracted twice liquid, extracting solution is filtered with 200 order silks, remove filtering residue, obtain filtrate; Filtrate is placed in to concentration tank, controls temperature at 70 DEG C, vacuum-0.05MPa, being concentrated into and measuring relative density at 60 DEG C is to stop concentrating for 1.30 o'clock, obtains concentrated solution; Concentrated solution is carried out to vacuum drying, 60 DEG C of baking temperatures, vacuum-0.08MPa, is dried to moisture below 5%, obtains dry extract; With pulverizer, dry extract is pulverized, crossed 80 mesh sieves, the powder that gets dry extract, for subsequent use;
(2) sieving of chitosan, starch: chitosan, starch are crossed respectively 80 mesh sieves, for subsequent use;
(3) mixing granulation: dried cream powder and chitosan, starch are placed in to mixer mixing 30min, spray into mass fraction and be 95% alcoholic solution and prepare soft material, make soft material reach " that holds is agglomerating, gently pinches loose ", then fill 20 eye mesh screens with granulator and granulate; Wet granular is laid in basin, is dried to moisture below 5% at 60 DEG C; Dried granule is crossed to 20 eye mesh screens and carry out granulate, for subsequent use;
(4) capsule-filling: the granule making is delivered to capsule-filling chamber, by Autocapsulefillingmachine filling, capsule specification 450mg/ grain, content uniformity of regular check;
(5) capsule polishing, subpackage: after capsule-filling, with buffing machine, capsule is carried out to polishing, and sort out capsule off quality; Capsule is packed in Medical high-density vinyon bottle, 60/bottle, packaging.
Embodiment bis-
Preventing and treating a chitosan composite for diabetes, is to be that primary raw material is prepared from by chitosan, Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma and starch.
In primary raw material, the mass percent of each component is as follows: chitosan 17%, and Radix Puerariae 14%, Radix Rehmanniae 12%, Fructus Momordicae charantiae 12%, the Radix Astragali 14%, Rhizoma Polygonati Odorati 12%, Ganoderma 13%, starch 6%, the mass percent sum of above-mentioned each component is 100%.
The preparation method of the described chitosan composite of preventing and treating diabetes, comprises the following steps:
(1) medical material dried cream powder preparation: the premenstrual processing of Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma that quality standard is up to the standards is put into extraction pot after cleaning, extracting in water 2 times, add for the first time the water of 10 times of quality of medicinal materials, first soak 1 hour, in extraction pot, pass into Steam Heating again, to 100 DEG C of beginning timing, decoct 2 hours, obtain extracting solution one time; Add for the second time the water of 8 times of quality of medicinal materials, decoct 1.5 hours, obtain secondary raffinate; Merge extracted twice liquid, extracting solution is filtered with 200 order silks, remove filtering residue, obtain filtrate; Filtrate is placed in to concentration tank, controls temperature at 60 DEG C, vacuum-0.04MPa, being concentrated into and measuring relative density at 60 DEG C is to stop concentrating for 1.30 o'clock, obtains concentrated solution; Concentrated solution is carried out to vacuum drying, 60 DEG C of baking temperatures, vacuum-0.08MPa, is dried to moisture below 5%, obtains dry extract; With pulverizer, dry extract is pulverized, crossed 80 mesh sieves, the powder that gets dry extract, for subsequent use;
(2) sieving of chitosan, starch: chitosan, starch are crossed respectively 80 mesh sieves, for subsequent use;
(3) mixing granulation: dried cream powder and chitosan, starch are placed in to mixer mixing 30min, spray into mass fraction and be 95% alcoholic solution and prepare soft material, make soft material reach " that holds is agglomerating, gently pinches loose ", then fill 20 eye mesh screens with granulator and granulate; Wet granular is laid in basin, is dried to moisture below 5% at 60 DEG C; Dried granule is crossed to 20 eye mesh screens and carry out granulate, for subsequent use;
(4) capsule-filling: the granule making is delivered to capsule-filling chamber, by Autocapsulefillingmachine filling, capsule specification 450mg/ grain, content uniformity of regular check;
(5) capsule polishing, subpackage: after capsule-filling, with buffing machine, capsule is carried out to polishing, and sort out capsule off quality; Capsule is packed in Medical high-density vinyon bottle, 60/bottle, packaging.
Embodiment tri-
Preventing and treating a chitosan composite for diabetes, is to be that primary raw material is prepared from by chitosan, Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma and starch.
In primary raw material, the mass percent of each component is as follows: chitosan 19%, and Radix Puerariae 16%, Radix Rehmanniae 14%, Fructus Momordicae charantiae 14%, the Radix Astragali 12%, Rhizoma Polygonati Odorati 10%, Ganoderma 11%%, starch 4%, the mass percent sum of above-mentioned each component is 100%.
The preparation method of the described chitosan composite of preventing and treating diabetes, comprises the following steps:
(1) medical material dried cream powder preparation: the premenstrual processing of Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma that quality standard is up to the standards is put into extraction pot after cleaning, extracting in water 2 times, add for the first time the water of 10 times of quality of medicinal materials, first soak 1 hour, in extraction pot, pass into Steam Heating again, to 100 DEG C of beginning timing, decoct 2 hours, obtain extracting solution one time; Add for the second time the water of 8 times of quality of medicinal materials, decoct 1.5 hours, obtain secondary raffinate; Merge extracted twice liquid, extracting solution is filtered with 200 order silks, remove filtering residue, obtain filtrate; Filtrate is placed in to concentration tank, controls temperature at 80 DEG C, vacuum-0.06MPa, being concentrated into and measuring relative density at 60 DEG C is to stop concentrating for 1.30 o'clock, obtains concentrated solution; Concentrated solution is carried out to vacuum drying, 60 DEG C of baking temperatures, vacuum-0.08MPa, is dried to moisture below 5%, obtains dry extract; With pulverizer, dry extract is pulverized, crossed 80 mesh sieves, the powder that gets dry extract, for subsequent use;
(2) sieving of chitosan, starch: chitosan, starch are crossed respectively 80 mesh sieves, for subsequent use;
(3) mixing granulation: dried cream powder and chitosan, starch are placed in to mixer mixing 30min, spray into mass fraction and be 95% alcoholic solution and prepare soft material, make soft material reach " that holds is agglomerating, gently pinches loose ", then fill 20 eye mesh screens with granulator and granulate; Wet granular is laid in basin, is dried to moisture below 5% at 60 DEG C; Dried granule is crossed to 20 eye mesh screens and carry out granulate, for subsequent use;
(4) capsule-filling: the granule making is delivered to capsule-filling chamber, by Autocapsulefillingmachine filling, capsule specification 450mg/ grain, content uniformity of regular check;
(5) capsule polishing, subpackage: after capsule-filling, with buffing machine, capsule is carried out to polishing, and sort out capsule off quality; Capsule is packed in Medical high-density vinyon bottle, 60/bottle, packaging.
Enforcement one capsule making is got to content and carry out safety evaluatio zoopery, every experiment and experimental result are as follows:
(1) acute oral toxicity test: chitosan composite of the present invention is all nontoxic under maximum tolerated dose to female, the male mice of Kunming kind;
(2) three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test): result is all negative;
(3) 30 days feeding trials: successively taking 1.125g/kg.bw, 2.250g/kg.bw, 4.500g/kg.bw dosage as basic, normal, high dosage group, taking normal saline as matched group, give respectively rat oral gavage 30 days.Experimental session, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ weights and internal organs/body weight ratio and matched group comparison, difference that there are no significant (P>0.05); Rat is dissected with tissue pathology checking and has no the obviously abnormal change relevant with sample.Prompting is fed and rat was had no to obvious toxic-side effects in 30 days with chitosan composite of the present invention.
More than experimental results show that chitosan composite of the present invention is safe, can relievedly take.
Separately, through animal function and bodily fuctions's test-meal test, prove that chitosan composite of the present invention has good function of blood sugar reduction to diabetes.
The foregoing is only preferred embodiment of the present invention, all equalizations of doing according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (5)
1. a chitosan composite of preventing and treating diabetes, is characterized in that: described chitosan composite is that primary raw material is prepared from by chitosan, Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma and starch.
2. prevent and treat according to claim 1 the chitosan composite of diabetes, it is characterized in that: in primary raw material, the mass percent of each component is as follows: chitosan 17-19%, Radix Puerariae 14-16%, Radix Rehmanniae 12-14%, Fructus Momordicae charantiae 12-14%, Radix Astragali 12-14%, Rhizoma Polygonati Odorati 10-12%, Ganoderma 11%-13%, starch 4-6%, the mass percent sum of above-mentioned each component is 100%.
3. the chitosan composite of preventing and treating according to claim 1 diabetes, is characterized in that: in primary raw material, the mass percent of each component is as follows: chitosan 18%, Radix Puerariae 15%, Radix Rehmanniae 13%, Fructus Momordicae charantiae 13%, the Radix Astragali 13%, Rhizoma Polygonati Odorati 11%, Ganoderma 12, starch 5%.
4. a preparation method of preventing and treating as claimed in claim 1 the chitosan composite of diabetes, is characterized in that: described preparation method comprises the following steps:
(1) medical material dried cream powder preparation: the premenstrual processing of Radix Puerariae, Radix Rehmanniae, Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati Odorati, Ganoderma that quality standard is up to the standards is put into extraction pot after cleaning, extracting in water 2 times, merges extracted twice liquid, and extracting solution is filtered with 200 order silks, remove filtering residue, obtain filtrate; Filtrate is placed in to concentration tank, controls temperature at 60～80 DEG C, vacuum-0.04～-0.06MPa, being concentrated into and measuring relative density at 60 DEG C is to stop concentrating for 1.30 o'clock, obtains concentrated solution; Concentrated solution is carried out to vacuum drying, 60 DEG C of baking temperatures, vacuum-0.08MPa, is dried to moisture below 5%, obtains dry extract; With pulverizer, dry extract is pulverized, crossed 80 mesh sieves, the powder that gets dry extract, for subsequent use;
(2) sieving of chitosan, starch: chitosan, starch are crossed respectively 80 mesh sieves, for subsequent use;
(3) mixing granulation: dried cream powder and chitosan, starch are placed in to mixer mixing 30min, spray into mass fraction and be 95% alcoholic solution and prepare soft material, make soft material reach " that holds is agglomerating, gently pinches loose ", then fill 20 eye mesh screens with granulator and granulate; Wet granular is laid in basin, is dried to moisture below 5% at 60 DEG C; Dried granule is crossed to 20 eye mesh screens and carry out granulate, for subsequent use;
(4) capsule-filling: the granule making is delivered to capsule-filling chamber, by Autocapsulefillingmachine filling, capsule specification 450mg/ grain, content uniformity of regular check;
(5) capsule polishing, subpackage: after capsule-filling, with buffing machine, capsule is carried out to polishing, and sort out capsule off quality; Capsule is packed in Medical high-density vinyon bottle, 60/bottle, packaging.
5. prevent and treat according to claim 4 the preparation method of the chitosan composite of diabetes, it is characterized in that: in step (1), the method for 2 water extraction is: the water that adds for the first time 10 times of quality of medicinal materials, first soak 1 hour, in extraction pot, pass into Steam Heating again, to 100 DEG C of beginning timing, decoct 2 hours, obtain extracting solution one time; Add for the second time the water of 8 times of quality of medicinal materials, decoct 1.5 hours, obtain secondary raffinate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905111A (en) * | 2015-06-16 | 2015-09-16 | 青岛浩大海洋保健食品有限公司 | Health-care chitosan capsule with blood glucose reducing effect |
| CN106943497A (en) * | 2017-03-02 | 2017-07-14 | 陕西二生物科技有限公司 | A kind of composition with ease constipation effect and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223135A (en) * | 1998-01-16 | 1999-07-21 | 彭湃 | Capsule for rehabilitation and health care of patient of diabetes |
| CN101450166A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
-
2014
- 2014-05-28 CN CN201410229760.XA patent/CN103989938A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223135A (en) * | 1998-01-16 | 1999-07-21 | 彭湃 | Capsule for rehabilitation and health care of patient of diabetes |
| CN101450166A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905111A (en) * | 2015-06-16 | 2015-09-16 | 青岛浩大海洋保健食品有限公司 | Health-care chitosan capsule with blood glucose reducing effect |
| CN106943497A (en) * | 2017-03-02 | 2017-07-14 | 陕西二生物科技有限公司 | A kind of composition with ease constipation effect and preparation method thereof |
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Application publication date: 20140820 |
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