CN101450166A - Traditional Chinese medicine composition with blood-sugar function and preparation method thereof - Google Patents
Traditional Chinese medicine composition with blood-sugar function and preparation method thereof Download PDFInfo
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- CN101450166A CN101450166A CNA2007101785076A CN200710178507A CN101450166A CN 101450166 A CN101450166 A CN 101450166A CN A2007101785076 A CNA2007101785076 A CN A2007101785076A CN 200710178507 A CN200710178507 A CN 200710178507A CN 101450166 A CN101450166 A CN 101450166A
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- fructus momordicae
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Abstract
The invention discloses a traditional Chinese medicine composition with hypoglycemic function and preparation method thereof. The traditional Chinese medicine is made from balsam pear, mulberry leaf and polyghace seche according to a certain weight proportion; and it can be made into any common oral taken preparation form. The Chinese traditional medicine composition in the invention achieves hypoglycemic function, and can be used to treat diabetes.
Description
Technical field
The wood invention relates to a kind of Chinese medicine composition with function of blood sugar reduction and preparation method thereof, belongs to Chinese medicine and field of health care food.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering Chinese medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of Chinese medicine composition with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Momordicae charantiae 10-30 part, Folium Mori 5-9 part and Rhizoma Polygonati Odorati 6-12 part.
Be preferably:
9 parts of 15 parts in Fructus Momordicae charantiae, 7 parts on Folium Mori and Rhizoma Polygonati Odorati.
The preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Momordicae charantiae with described weight proportion, Folium Mori and Rhizoma Polygonati Odorati add water or ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Momordicae charantiae with described weight proportion, Folium Mori and Rhizoma Polygonati Odorati add twice of the ethanol extraction of 10 times of amounts and 8 times amount 70%, filter, merging filtrate, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The using method of Chinese medicine composition of the present invention (is example with tablet, capsule, granule):
Tablet: oral, every day 2 times, each 3 (every contains crude drug 3.5-8.5g)
Capsule: oral, every day 2 times, each 3 (every contains crude drug 3.5-8.5g)
Granule: oral, every day 2 times, each 1 bag (whenever containing a bag crude drug 10.5-25.5g)
Each drug mechanism is as follows among the present invention:
Fructus Momordicae charantiae: having clears away heart-fire makes eye bright, the effect of QI invigorating antipyretic, and Fructus Momordicae charantiae contains Charantin, Charantin etc., and pharmacological evaluation proves that Fructus Momordicae charantiae has the effect of tangible blood sugar lowering.
Folium Mori: effect with heat-clearing and toxic substances removing, removing heat from blood.Pharmacological research shows that Folium Mori have hypoglycemic activity, and its contained ecdysterone all has blood sugar reducing function to the inductive blood sugar increasing of several different methods, can promote that conversion of glucose is a glycogen, but not change intact animal's blood glucose.
Rhizoma Polygonati Odorati: have yin nourishing, moisturize, relieving restlessness, effect such as quench the thirst, pharmacological research shows that Rhizoma Polygonati Odorati has blood fat reducing and blood glucose effect, and the hyperglycemia that epinephrine is caused has remarkable inhibitory action.
In the present composition, Fructus Momordicae charantiae is less edible in people's diet as the plant of bitterness is arranged, and has wherein contained the trace element of a large amount of diabetes patient's needs; Folium Mori have the effect of clearing away heat and cooling blood, can correct the phenomenon that ubiquitous hyperactivity of fire caused by deficiency of YIN among the diabetes patient or stomach have excess-fire; Rhizoma Polygonati Odorati relieving restlessness, the effect of quenching the thirst can be eliminated the common agitation of diabetes patient, thirsty phenomenon; Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has that clearing away heat and cooling blood, relieving restlessness quench the thirst, hypoglycemic effect.Can be used for treating diabetes.Can be used for preparing the Chinese medicine and the health product of prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
For showing the hypoglycemic effect of the present invention, entrust the specified health food functional check of Ministry of Public Health mechanism the present invention to be carried out the animal experiment of blood sugar regulation to diabetes.Table 1 is the influence of the present invention to alloxan induced hyperglycemia rat blood sugar, and table 2 is the influence of wood invention to alloxan induced hyperglycemia rat post-prandial glycemia, and table 3 is the influence of the present invention to normal rat blood sugar.
Table 1 the present invention is to the influence of alloxan induced hyperglycemia rat blood sugar
* compare p＜0.05 with the hyperglycemia model group
Table 2 the present invention is to the influence of alloxan induced hyperglycemia rat post-prandial glycemia
* p＜0.01 of comparing with the hyperglycemia model group
Table 3 the present invention is to the influence of normal rat blood sugar (X ± SD)
Test initial stage F=0.011, P=0.998; Test F=2.102 in latter stage, P=0.118
Table 1-3 result shows that the present invention does not have influence to normal rat blood sugar.High dose of the present invention has tangible reduction effect to the hyperglycemic rat blood glucose due to the alloxan, and middle and high dosage can improve the carbohydrate tolerance by the caused hyperglycemic rat of alloxan.
The specific embodiment
Embodiment 1:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 10kg, Folium Mori 5kg and Rhizoma Polygonati Odorati 6kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Folium Mori 9kg and Rhizoma Polygonati Odorati 12kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Folium Mori 9kg and Rhizoma Polygonati Odorati 6kg, standby;
B) Fructus Momordicae charantiae, Semen Fagopyri Esculenti and Folium Mori are extracted twice with 10 times of amounts and 8 times of water gagings, merge filtrate twice, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 15kg, Folium Mori 7kg and Rhizoma Polygonati Odorati 9kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 80%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Folium Mori 9kg and Rhizoma Polygonati Odorati 9kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 6:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 12kg, Folium Mori 7kg and Rhizoma Polygonati Odorati 6kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 7:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Folium Mori 7kg and Rhizoma Polygonati Odorati 9kg, standby;
B) with Fructus Momordicae charantiae, Semen Fagopyri Esculenti and the Folium Mori ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of Chinese medicine composition with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: Fructus Momordicae charantiae 10-30 part, Folium Mori 5-9 part and Rhizoma Polygonati Odorati 6-12 part.
According to the Chinese medicine composition of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 9 parts of 15 parts in Fructus Momordicae charantiae, 7 parts on Folium Mori and Rhizoma Polygonati Odorati.
3, the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that, this method is:
Fructus Momordicae charantiae, Folium Mori and the Rhizoma Polygonati Odorati of described weight proportion added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, the preparation method of Chinese medicine composition according to claim 3 is characterized in that, it comprises the following steps:
Fructus Momordicae charantiae, Folium Mori and the Rhizoma Polygonati Odorati of described weight proportion added 70% ethanol extract 2 times, extracting solution is merged, the concentrating under reduced pressure relative density is measured 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract, is ground into powder, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described Chinese medicine compositions are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785076A CN101450166A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
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| CNA2007101785076A CN101450166A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
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| CN101450166A true CN101450166A (en) | 2009-06-10 |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102224931A (en) * | 2011-06-01 | 2011-10-26 | 四川科伦新光健康药业有限公司 | Composition assisting in reduction of blood sugar |
| CN103301310A (en) * | 2013-05-11 | 2013-09-18 | 刘越泽 | Blood glucose-reducing Chinese medicine preparation and preparation method thereof |
| CN103989938A (en) * | 2014-05-28 | 2014-08-20 | 高益槐 | Chitosan composition for preventing and treating diabetes and preparation method of chitosan composition |
| CN104173734A (en) * | 2013-05-28 | 2014-12-03 | 北京中医药大学 | Pharmaceutical composition for treating impaired glucose regulation and preparation method thereof |
| CN104857088A (en) * | 2015-06-14 | 2015-08-26 | 威海紫光金奥力生物技术有限公司 | Preparation method of mulberry leaf compound capsule for lowering blood glucose in assistant manner |
| CN105194307A (en) * | 2015-09-17 | 2015-12-30 | 上海秋橙新材料科技有限公司 | Blood-sugar-decreasing tea |
| CN105267755A (en) * | 2015-11-19 | 2016-01-27 | 刘庆华 | Blood-glucose-reducing oral liquid |
| CN106605822A (en) * | 2016-12-19 | 2017-05-03 | 西安源森生物科技有限公司 | Composition facilitating reducing of blood sugar and preparation method of composition |
| CN106606529A (en) * | 2016-12-27 | 2017-05-03 | 南京圣诺生物科技实业有限公司 | Composition with auxiliary blood sugar reduction efficacy, and preparation method and application thereof |
| CN106975012A (en) * | 2017-05-18 | 2017-07-25 | 成都中医药大学 | A kind of traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof |
| CN107625129A (en) * | 2017-09-06 | 2018-01-26 | 如皋市滋生堂生物科技有限公司 | A kind of hypoglycemic and the health food and its production method of reducing blood lipid |
| CN108771717A (en) * | 2018-09-11 | 2018-11-09 | 山西中医药大学 | A kind of hypoglycemic health drink, preparation method and application |
| CN109394970A (en) * | 2019-01-14 | 2019-03-01 | 楚雄州百草岭药业发展有限公司 | A kind of mulberry leaf composition and preparation method thereof, preparation and application |
| CN110251655A (en) * | 2019-07-31 | 2019-09-20 | 张先奇 | A kind of pharmaceutical composition and preparation method thereof for treating diabetes |
| CN111821380A (en) * | 2020-07-31 | 2020-10-27 | 深圳市清生元生物技术股份有限公司 | Hypoglycemic composition and preparation method and application thereof |
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2007
- 2007-11-30 CN CNA2007101785076A patent/CN101450166A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102224931B (en) * | 2011-06-01 | 2013-03-06 | 四川科伦新光健康药业有限公司 | Composition assisting in reduction of blood sugar |
| CN102224931A (en) * | 2011-06-01 | 2011-10-26 | 四川科伦新光健康药业有限公司 | Composition assisting in reduction of blood sugar |
| CN103301310A (en) * | 2013-05-11 | 2013-09-18 | 刘越泽 | Blood glucose-reducing Chinese medicine preparation and preparation method thereof |
| CN104173734B (en) * | 2013-05-28 | 2017-11-10 | 北京中医药大学 | A kind of pharmaceutical composition for treating IGR and preparation method thereof |
| CN104173734A (en) * | 2013-05-28 | 2014-12-03 | 北京中医药大学 | Pharmaceutical composition for treating impaired glucose regulation and preparation method thereof |
| CN103989938A (en) * | 2014-05-28 | 2014-08-20 | 高益槐 | Chitosan composition for preventing and treating diabetes and preparation method of chitosan composition |
| CN104857088A (en) * | 2015-06-14 | 2015-08-26 | 威海紫光金奥力生物技术有限公司 | Preparation method of mulberry leaf compound capsule for lowering blood glucose in assistant manner |
| CN105194307A (en) * | 2015-09-17 | 2015-12-30 | 上海秋橙新材料科技有限公司 | Blood-sugar-decreasing tea |
| CN105267755A (en) * | 2015-11-19 | 2016-01-27 | 刘庆华 | Blood-glucose-reducing oral liquid |
| CN106605822A (en) * | 2016-12-19 | 2017-05-03 | 西安源森生物科技有限公司 | Composition facilitating reducing of blood sugar and preparation method of composition |
| CN106606529A (en) * | 2016-12-27 | 2017-05-03 | 南京圣诺生物科技实业有限公司 | Composition with auxiliary blood sugar reduction efficacy, and preparation method and application thereof |
| CN106975012A (en) * | 2017-05-18 | 2017-07-25 | 成都中医药大学 | A kind of traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof |
| CN107625129A (en) * | 2017-09-06 | 2018-01-26 | 如皋市滋生堂生物科技有限公司 | A kind of hypoglycemic and the health food and its production method of reducing blood lipid |
| CN108771717A (en) * | 2018-09-11 | 2018-11-09 | 山西中医药大学 | A kind of hypoglycemic health drink, preparation method and application |
| CN109394970A (en) * | 2019-01-14 | 2019-03-01 | 楚雄州百草岭药业发展有限公司 | A kind of mulberry leaf composition and preparation method thereof, preparation and application |
| CN110251655A (en) * | 2019-07-31 | 2019-09-20 | 张先奇 | A kind of pharmaceutical composition and preparation method thereof for treating diabetes |
| CN111821380A (en) * | 2020-07-31 | 2020-10-27 | 深圳市清生元生物技术股份有限公司 | Hypoglycemic composition and preparation method and application thereof |
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Open date: 20090610 |