CN101491580A - Combination with blood sugar reducing function and preparation method thereof - Google Patents
Combination with blood sugar reducing function and preparation method thereof Download PDFInfo
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- CN101491580A CN101491580A CNA2008100566983A CN200810056698A CN101491580A CN 101491580 A CN101491580 A CN 101491580A CN A2008100566983 A CNA2008100566983 A CN A2008100566983A CN 200810056698 A CN200810056698 A CN 200810056698A CN 101491580 A CN101491580 A CN 101491580A
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Abstract
The invention discloses a composition with the function of reducing blood sugar and a preparation method thereof. The composition is prepared from rice bran crude polyoses, cactus extract and guava leaf extract according to certain weight proportion. The composition can be prepared into any common preparation formulation. The composition of the invention has the efficacy of reducing blood sugar, and can be used for treating diabetes.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, belong to medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of compositions with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Rice-bran crude polysaccharide 0.5-5 part, Radix et Caulis Opuntiae Dillenii extract 0.1-10 part, Folium Psidii Guajavae extract 0.1-10 part.
Be preferably:
2 parts of rice-bran crude polysaccharide, 1 part of Radix et Caulis Opuntiae Dillenii extract, 1 part of Folium Psidii Guajavae extract.
The preparation method of the present composition is as follows:
Testa oryzae is pushed in defat, the hot water lixiviate, centrifugal, get supernatant, enzymolysis, centrifugal, get supernatant, adjust pH, centrifugal, get supernatant, add the ethanol standing over night, centrifugal, get precipitation, will precipitate lyophilization or spray drying, pulverize, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process, filter, get filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; Folium Psidii Guajavae water or different concentration ethanol are extracted, get Folium Psidii Guajavae extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
The preferred for preparation method of the present composition is as follows:
Testa oryzae (crossing 120 mesh sieves) is pushed in defat, the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
Wherein, described rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract can also outsourcings.
Drug mechanism of the present invention is as follows:
Rice-bran crude polysaccharide: rice bran polysaccharide (RBP) (Rice Bran Polysacchride, RBP) be present in the caryopsis cortex of Oryza glutinosa, mainly be meant the class non-starch polysaccharides(nsp) that molecular weight does not wait, its chemical constitution is with all polysaccharide is different, be baroque heteroglycan, mainly contain lipopolysaccharide, araboxylan and glucosan etc.The Testa oryzae active polysaccharide not only has the physiological function of general active polysaccharide, but also has the function of control old cardiovascular diseases such as stronger raising blood serum tumor necrosin level, enhancing human body immunity function and blood sugar lowering, blood pressure lowering, cholesterol reducing.Adopt streptozotocin (STZ) to bring out experimental diabetic animal scale-model investigation rice bran polysaccharide (RBP) to the hypoglycemic effect of diabetic mice and to the influence of its hepatic antioxidative function, result of the test shows: compare with diabetic model group, the rice bran polysaccharide (RBP) of middle and high dosage can significantly reduce the blood sugar level (P＜0.05) of diabetic mice, obviously improve its glucose tolerance (P＜0.05), significantly improve liver SOD, GSH-Px activity (P＜0.05), and can obviously reduce MDA content in the liver (P＜0.05).
The Radix et Caulis Opuntiae Dillenii extract: Radix et Caulis Opuntiae Dillenii bitter in the mouth cold in nature has the effect of detoxifcation analgesia, detumescence and apocenosis, promoting flow of QI and blood.Pharmacological research shows that Radix et Caulis Opuntiae Dillenii has the obvious functions of blood sugar effect, can improve type ii diabetes patient's carbohydrate metabolism effectively.On Mexico, the U.S. and other places, Radix et Caulis Opuntiae Dillenii is used to treat diseases such as diabetes, ulcer, has been made into various tablets and soft gelatin capsule.In China, the Radix et Caulis Opuntiae Dillenii compound preparation also is used for treating diabetes.In the test that the alloxan diabetes model that with Wistar is animal pattern foundation carries out, find; The extract of Radix et Caulis Opuntiae Dillenii does not have obvious influence to normal rat blood sugar, but can significantly reduce the blood glucose of model induced by alloxan diabetes rat, and its blood sugar reducing function is relevant with dosage.Its high dose can also significantly reduce diabetes rat 24h urine amount.Simultaneously, induce at streptozotocin (STZ) on the rat diabetes model basis of foundation, Radix et Caulis Opuntiae Dillenii juice is used for the treatment of the disease Mus.The result shows that it is normal that its glucose amount of the diabetic mice of administration group and serum insulin levels are recovered, and matched group is still unusual, shows that the Radix et Caulis Opuntiae Dillenii extract has the effect for the treatment of diabetes, improving insulin resistant.
Folium Psidii Guajavae: sweet, puckery, flat.Function: astringing to arrest diarrhea, anti-inflammation hemostasia.Leaf, really: acute and chronic enteritis, dysentery, infantile dyspepsia; Bright leaf: traumatic injury is controlled in external, traumatic hemorrhage, ecthyma disunion of a specified duration.Recent study finds that Fructus psidii guajavae immaturus has good blood sugar lowering, effect for reducing fat, and Folium Psidii Guajavae is to have the sensitivity that improves Insulin receptor INSR, thereby has the effect of blood sugar lowering.It (is the B cell of alloxan damage pancreas islets of langerhans that this experiment is made diabetes model with the tail vein injection alloxan, cause insulin secretion to reduce, blood sugar increasing), different extract for treating with Folium Psidii Guajavae, the result shows that the treatment group has the obvious functions of blood sugar effect than model control group, and ethanol extract treatment group acts on the most obvious in three groups of treatment groups, thereby verified that not only Folium Psidii Guajavae has hypoglycemic activity very doughtily, and the foundation of science is provided for the exploitation of its effective ingredient.
In the present composition, rice-bran crude polysaccharide contains the beneficial element of the usual fewer contact of diabetes patient as the material that extracts from coarse grain; Radix et Caulis Opuntiae Dillenii has the effect of detoxifcation analgesia, detumescence and apocenosis, can effectively discharge the intravital toxin of diabetes patient; Folium Psidii Guajavae has the effect of antiinflammatory, can prevent and treat diabetic complication; Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has the effect of detoxifcation analgesia, detumescence and apocenosis, antiinflammatory, additional multiple beneficial element.Can be used for prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of compositions of the present invention by following experiment.
1 materials and methods
1.1 experiment material:
Experimental subject: 40 of Wistar rats, male and female half and half, body weight 160 ± 20g.
Experimental drug: present composition extract, alloxan, glucose oxidase enzyme reagent kit.
Experiment equipment: 4 of spectrophotometer standard cuvettes, the rat oral gavage pin props up, corresponding No. 4, No. 5 syringe needles of 5mi syringe, test tube, dropper, pipet, scalpel.
1.2 experimental technique:
Modelling: with getting 30 rats (male and female half and half), by 250mg/kg lumbar injection alloxan (being dissolved in aseptic injection water).2 survey blood glucose before and after modeling are defined as whole modelings successes.
The experiment grouping: modeling success rat is divided into three groups (male and female half and half) at random, and remaining rat is one group:
First group: normal blank group; Every day normal diet.
Second group: not administration of Cheng Mo group; Every day, normal saline was irritated stomach, normal diet.
The 3rd group: become mould low dosage administration group; Every 100mg/kg body weight of pressing is greatly irritated stomach, normal diet with present composition extract.
The 4th group: become mould high dose administration group; Press the 200mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
1.3 experimental index: laboratory animal tail point is got blood, surveys concentration of glucose in the blood.
1.4 date processing: (x ± s) expression, relatively check with t in the group by data with means standard deviation for each index.
2 results: see Table 1
The statistical value of each experimental group of table 1
Compare * P＜0.05 with matched group, * * P＜0.01
The result shows, low dose therapy group of the present invention compares with matched group that there were significant differences (* P＜0.05), high-dose therapy group of the present invention is compared the difference (* * P＜0.01) that highly significant is arranged with matched group, illustrate that the present composition has clear and definite hypoglycemic effect.
The specific embodiment
Embodiment 1:
The preparation of the capsule of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 2kg, Radix et Caulis Opuntiae Dillenii extract 1kg, Folium Psidii Guajavae extract 1kg, mix homogeneously, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 0.5kg, Radix et Caulis Opuntiae Dillenii extract 0.1kg, Folium Psidii Guajavae extract 0.1kg, be ground into powder, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 3:
The preparation of the granule of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 5kg, Radix et Caulis Opuntiae Dillenii extract 10kg, Folium Psidii Guajavae extract 10kg, be ground into powder, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 4:
The preparation of the tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 3kg, Radix et Caulis Opuntiae Dillenii extract 3kg, Folium Psidii Guajavae extract 1kg, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 5:
The preparation of the tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; Folium Psidii Guajavae is extracted with 10 times of amounts and 8 times of water gagings, and each 1 hour, merge extractive liquid, filtered, concentrating under reduced pressure, and drying is pulverized, and gets Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 5kg, Radix et Caulis Opuntiae Dillenii extract 3kg, Folium Psidii Guajavae extract 3kg, be ground into powder, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 6:
The preparation of the effervescent tablet of the present composition
A) defat is pushed Testa oryzae (crossing 120 mesh sieves), the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, (pH6.0 1h), adds saccharifying enzyme (pH4.0 to add alpha amylase, it is 1h), centrifugal that (3000r/min 20min), gets supernatant, add TCA (pH4.5), centrifugal (1200r/min 10min), gets supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
B) take by weighing rice-bran crude polysaccharide 4kg, Radix et Caulis Opuntiae Dillenii extract 2kg, Folium Psidii Guajavae extract 2kg, be ground into powder, mix homogeneously, add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate drying with dehydrated alcohol, add the lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of compositions with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: rice-bran crude polysaccharide 0.5-5 part, Radix et Caulis Opuntiae Dillenii extract 0.1-10 part, Folium Psidii Guajavae extract 0.1-10 part.
According to the compositions of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 2 parts of rice-bran crude polysaccharide, 1 part of Radix et Caulis Opuntiae Dillenii extract, 1 part of Folium Psidii Guajavae extract.
3, claim 1 or 2 described preparation of compositions methods is characterized in that this method is: Testa oryzae is pushed in defat, the hot water lixiviate, centrifugal, get supernatant, enzymolysis, centrifugal, get supernatant, adjust pH, centrifugal, get supernatant, add the ethanol standing over night, centrifugal, get precipitation, to precipitate lyophilization or spray drying, pulverize, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process, filter, get filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; Folium Psidii Guajavae water or different concentration ethanol are extracted, get Folium Psidii Guajavae extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, preparation of compositions method according to claim 3 is characterized in that, it comprises the following steps: Testa oryzae (crossing 120 mesh sieves) is pushed in defat, the hot water lixiviate, centrifugal (3000r/min, 20min), get supernatant, add alpha amylase (pH6.0,1h), add saccharifying enzyme (pH4.0,1h), centrifugal (3000r/min, 20min), get supernatant, add TCA (pH4.5), centrifugal (1200r/min, 10min), get supernatant, 75% ethanol standing over night, centrifugal (1200r/min, 10min), get precipitation, will precipitate lyophilization or spray drying, obtain rice-bran crude polysaccharide; With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With rice-bran crude polysaccharide, Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described compositionss are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100566983A CN101491580A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN102217686A (en) * | 2011-06-02 | 2011-10-19 | 王乃利 | Hypoglycemic tea and preparation method thereof |
-
2008
- 2008-01-23 CN CNA2008100566983A patent/CN101491580A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN101999668B (en) * | 2010-10-11 | 2012-05-23 | 孙羽蒙 | Composition for treating diabetes mellitus |
| CN102217686A (en) * | 2011-06-02 | 2011-10-19 | 王乃利 | Hypoglycemic tea and preparation method thereof |
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