CN101450096A - Medicine composition with blood-sugar reduction function and preparation method thereof - Google Patents
Medicine composition with blood-sugar reduction function and preparation method thereof Download PDFInfo
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- CN101450096A CN101450096A CNA2007101785165A CN200710178516A CN101450096A CN 101450096 A CN101450096 A CN 101450096A CN A2007101785165 A CNA2007101785165 A CN A2007101785165A CN 200710178516 A CN200710178516 A CN 200710178516A CN 101450096 A CN101450096 A CN 101450096A
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- propolis
- chromium picolinate
- fructus momordicae
- tea polyphenols
- momordicae charantiae
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Abstract
The invention discloses a pharmaceutical composition with hypoglycemic function and preparation method thereof. The invention is made from bitter melon, tea polyphenol, Chromium picolinate and propolis according to a certain weight proportion; and it can be made into any common oral taken preparation form. The Chinese traditional medicine composition in the invention achieves hypoglycemic function, and can be used to treat diabetes.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of hypoglycemic drug and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of pharmaceutical composition with function of blood sugar reduction.
Another object of the present invention has provided this preparation of drug combination method.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Momordicae charantiae 5-30 part, tea polyphenols 0.3-0.8 part, chromium picolinate 0.001-0.009 part, propolis 0.1-0.5 part
Be preferably:
20 parts in Fructus Momordicae charantiae, 0.5 part of tea polyphenols, 0.006 part of chromium picolinate, 0.3 part of propolis
Preparation of drug combination method of the present invention is as follows:
The Fructus Momordicae charantiae of described weight proportion is added water or ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add propolis, chromium picolinate, tea polyphenols, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Twice of the ethanol extraction that the Fructus Momordicae charantiae of described weight proportion is added 10 times of amounts and 8 times of amounts 70%, merge extractive liquid,, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into powder, add propolis, chromium picolinate, tea polyphenols, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The using method of Chinese medicine composition of the present invention:
Oral; Day dose is in crude drug: Fructus Momordicae charantiae 5-30g, tea polyphenols 0.3-0.8g, chromium picolinate 0.001-0.009g, propolis 0.1-0.5g, and preferred: Fructus Momordicae charantiae 20g, tea polyphenols 0.5g, chromium picolinate 0.006g, propolis 0.3g; Every day 2-3 time.
Each drug mechanism is as follows among the present invention:
Chromium picolinate: Cr3+ is the trace element of needed by human, and it is the constituent of glucose tolerance factor, has ILA, can promote the utilization of cell, promote the oxidative phosphorylation of glucose, promote glycogen synthetic glucose, improve the stability of insulin, thus blood sugar lowering.Pyridine carboxylic acid is the amino acid metabolites that produces in people and mammalian liver, the kidney, and is present in a large number in the food such as milk, and it combines closely into chromium picolinate with Cr3+, can be absorbed well by human body.Therefore chromium picolinate be a kind of by Ministry of Public Health allowed, can add the functional component in the health food to.Chromium picolinate can directly act on histiocyte by cell membrane smoothly, can strengthen insulin active, improves the human body carbohydrate metabolism.
Propolis: be that Apis is used the resin of gathering from plant plumule and trunk, the secretions in Hubei Province, Cera Flava, a small amount of pollen process on the Apis a kind ofly has an aromatic odor, and tough natural mixture has special fragrance during burning, and mildly bitter flavor is puckery.The main component of propolis has flavone, the rare class of terpene, organic acid, armaticity aldehydes and several amino acids enzyme, vitamin, mineral etc., and the effective ingredient of complexity is the material base of good natural health-care products and medicine in the propolis.Propolis energy activating cell promotes tissue regeneration, repairs sick islet cells and the tissue that decreases, the help blood sugar lowering; Diminish inflammation, treatment is infected, prevention and treatment infection complication; Blood fat reducing, vessel softening, microcirculation improvement, diabetics are taken propolis can prevent visual deterioration and cardiovascular and cerebrovascular complication; Regain one's strength, eliminate " three-many-one-little " symptom; But the diabetes patient adheres to taking propolis reinforced immunological function, and health invigorating is improved the quality of living.
Fructus Momordicae charantiae: having clears away heart-fire makes eye bright, the effect of QI invigorating antipyretic, and Fructus Momordicae charantiae contains Charantin, Charantin etc., and pharmacological evaluation proves that Fructus Momordicae charantiae has the effect of tangible blood sugar lowering.
Tea polyphenols: be the general name of polyphenols in the Folium Camelliae sinensis, tangible removing free radical and hypoglycemic effect are arranged.
In the present composition, Fructus Momordicae charantiae is as principal agent, wherein Fructus Momordicae charantiae is less edible in people's diet as the plant of bitterness is arranged, the trace element that has wherein contained a large amount of diabetes patient's needs, and the obvious functions of blood sugar effect is arranged, being aided with propolis diminishes inflammation, treatment is infected, microcirculation improvement, add again and can strengthen insulin active, improve the glycometabolic chromium picolinate of human body, remove the tea polyphenols of free radical, the four Chinese medicine compatibility is fundamentally regulated diabetes patient's body comprehensively, improves diabetes patient's physical condition, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has the QI invigorating nourishing YIN, the relieving restlessness that clears away heart-fire, diminishes inflammation, microcirculation improvement, blood sugar lowering, prevents and treats the extremely effect of infection complication of diabetes.Can be used for treating diabetes.Can be used for preparing the Chinese medicine and the health product of prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
According to Ministry of Public Health " provisions for new drugs approval " requirement, experiment moulding animal is selected healthy Wistar rat and Kunming kind white mice for use, with the alloxan animal glycosuria pathology moulding that experimentizes, adopt the known Western medicine phenbutamide of treatment diabetes sheet as this research control drug of dividing into groups.
The pharmacological research of this group system is total: medicine of the present invention is to the blood sugar influence of first section moulding animal, influence to serum insulin content, influence to blood glucagon content, to blood superoxide dismutase content (SOD) and active influence thereof, influence to liver tissue lipid peroxide content, to the metabolic influence of serum lipid, to the body fatigue resistance effect, influence to the organism adaptation ability, influence to the peritoneal macrophage phagocytic function, be model promptly, the relevant index of the group effect of this medicine blood sugar reducing function mechanism and medicine has been done mensuration than system with big (little) Mus of model induced by alloxan diabetes.
This experimental system pharmacological research confirms: (1) large and small dosage has very significantly repeatably hypoglycemic activity to different experiments moulding animal (large and small Mus).To studies show that of moulding mice, hypoglycemic effect is better than the Western medicine phenbutamide.And, show stronger after effect.(2) big low dose all can obviously improve insulin content in the moulding animal blood.Improve with drug level, the rising insulin content is more obvious.Simultaneously, reduce glucagon content in the blood.One of its hypoglycemic mechanism may be to reduce glucagon content, improves insulin content, and then, suppress liver glycogen and decompose and blood sugar lowering content.This blood sugar reducing function and effect are better than Western medicine phenbutamide group.(3) obviously improve with the same moulding animal blood superoxide dismutase (SOD) content that can make of phenbutamide, and can make the active raising of SOD in the blood, simultaneously, can obviously reduce Lpo in the hepatic tissue, harmful free radical effect in the tangible elimination body has been described.Be the treatment diabetes, improving the body vitality provides foundation.(4) general diabetics has more existing hyperlipemia, and the plasma concentration of T-CHOL (TC) and triglyceride (TG) is all apparently higher than the normal person.Plasma TC, the TG level is relevant with the control of the diabetes state of an illness.Hypercholesterolemia is the main cause of diabetes complicated macroangiopathic, medicine of the present invention can obviously reduce moulding animal TC and cholesterol acid (TCE) content, it is more obvious to increase dosage, can reduce serum high-density LP cholesterol (HDL-C), above-mentioned effect is better than the phenbutamide sheet, this effect is consistent with its obvious blood sugar reducing function, points out this medicine that the treatment diabetes are caused that the concurrent angiopathy of hyperlipemia is particularly suitable.
(5) general pharmacology studies show that, medicine of the present invention can obviously improve the mice swimming with a load attached to the body time, improve body resisting fatigue ability, can obviously improve mice to low temperature, pyritous adaptive capacity, enhancing body is to the adaptive capacity of environment, can obviously improve the mouse peritoneal emigrated cell and engulf the erythrocytic ability of chicken, thereby increase immunity of organisms.
The specific embodiment
Embodiment 1:
The preparation of the capsule of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, tea polyphenols 0.5kg, chromium picolinate 0.006kg, propolis 0.3kg, standby;
B) with the ethanol extraction twice of Fructus Momordicae charantiae with 10 times of amounts and 8 times of amounts 70%, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, adds propolis, tea polyphenols, chromium picolinate, appropriate amount of auxiliary materials, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 5kg, tea polyphenols 0.3kg, chromium picolinate 0.001kg, propolis 0.1kg, standby;
B) with the ethanol extraction twice of Fructus Momordicae charantiae with 10 times of amounts and 8 times of amounts 70%, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added propolis, tea polyphenols, chromium picolinate, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, tea polyphenols 0.8kg, chromium picolinate 0.009kg, propolis 0.5kg, standby;
B) Fructus Momordicae charantiae is extracted twice with 10 times of amounts and 8 times of water gagings, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added propolis, tea polyphenols, chromium picolinate, add ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, tea polyphenols 0.5kg, chromium picolinate 0.006kg, propolis 0.3kg, standby;
B) with the ethanol extraction twice of Fructus Momordicae charantiae with 10 times of amounts and 8 times of amounts 80%, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added propolis, tea polyphenols, chromium picolinate, add adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the effervescent tablet of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 25kg, tea polyphenols 0.5kg, chromium picolinate 0.006kg, propolis 0.3kg, standby;
B) with the ethanol extraction twice of Fructus Momordicae charantiae with 10 times of amounts and 8 times of amounts 70%, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added propolis, tea polyphenols, chromium picolinate, add tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 6:
The preparation of the dispersible tablet of pharmaceutical composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, tea polyphenols 0.5kg, chromium picolinate 0.006kg, propolis 0.3kg, standby;
B) with the ethanol extraction twice of Fructus Momordicae charantiae with 10 times of amounts and 8 times of amounts 70%, merge extractive liquid, filters, and reclaims ethanol, is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added propolis, tea polyphenols, chromium picolinate, add disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of pharmaceutical composition with hypoglycemic activity is characterized in that, said composition is to be made by following bulk drugs: Fructus Momordicae charantiae 5-30 part, tea polyphenols 0.3-0.8 part, chromium picolinate 0.001-0.009 part, propolis 0.1-0.5 part.
2, pharmaceutical composition according to claim 1 is characterized in that, said composition is to be made by following bulk drugs: 20 parts in Fructus Momordicae charantiae, 0.5 part of tea polyphenols, 0.006 part of chromium picolinate, 0.3 part of propolis.
3, claim 1 or 2 described preparation of drug combination methods is characterized in that this method is:
The Fructus Momordicae charantiae of described weight proportion is added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, adds propolis, tea polyphenols, chromium picolinate, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Twice of the ethanol extraction that the Fructus Momordicae charantiae of described weight proportion is added 10 times of amounts and 8 times of amounts 70%, merge extractive liquid,, filter, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30, drying under reduced pressure down for 60 ℃, make dry extract, be ground into powder, add propolis, tea polyphenols, chromium picolinate, be prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described pharmaceutical compositions are used to prepare prevention and the medicine of treatment diabetes or the application of health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785165A CN101450096A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785165A CN101450096A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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| CN101450096A true CN101450096A (en) | 2009-06-10 |
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| CNA2007101785165A Pending CN101450096A (en) | 2007-11-30 | 2007-11-30 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116849A (en) * | 2014-07-31 | 2014-10-29 | 射阳县庆缘康蜂产品厂 | Hypoglycaemic hard capsule and preparation method thereof |
| US9514341B2 (en) | 2014-03-31 | 2016-12-06 | Covidien Lp | Method, apparatus and article for detection of transponder tagged objects, for example during surgery |
-
2007
- 2007-11-30 CN CNA2007101785165A patent/CN101450096A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9514341B2 (en) | 2014-03-31 | 2016-12-06 | Covidien Lp | Method, apparatus and article for detection of transponder tagged objects, for example during surgery |
| CN104116849A (en) * | 2014-07-31 | 2014-10-29 | 射阳县庆缘康蜂产品厂 | Hypoglycaemic hard capsule and preparation method thereof |
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Open date: 20090610 |