CN100462085C - Bee product tablets for diabetes and their making method - Google Patents
Bee product tablets for diabetes and their making method Download PDFInfo
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- CN100462085C CN100462085C CNB2005100457126A CN200510045712A CN100462085C CN 100462085 C CN100462085 C CN 100462085C CN B2005100457126 A CNB2005100457126 A CN B2005100457126A CN 200510045712 A CN200510045712 A CN 200510045712A CN 100462085 C CN100462085 C CN 100462085C
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Abstract
A health-care food in the form of tablet for regulating blood pressure, blood sugar and blood fat and preventing and treating diabetes and its complecations is proportionally prepared from balsam pear, bee gelatin, red sage root, mulberry leaf and seabuckthorn leaf through extracting and mixing.
Description
Technical field the invention belongs to medicine or health food, relates to the medicine of a kind of blood sugar regulation, blood pressure and blood fat or health food tablet and preparation method thereof.
The background technology diabetes are one of height morbidities of modern society, and in recent years, the sickness rate of world's diabetes is ascendant trend year by year, and its mortality rate has become the third-largest disease after diseases of cardiovascular and cerebrovascular systems, cancer.According to WHO statistics, the whole world has diabetics about 1.8 hundred million, about more than 5,000 ten thousand people of China, about more than 2,000 ten thousand people of the U.S..The WHO prediction, the diabetes patient in Asia will be present 3 times very soon, the whole world will have 300,000,000 diabeticss, not only population risk has rising trend, and sickness rate is tending towards rejuvenation, teenage adolescent just finds to suffer from diabetes, the harm that visible diabetes relate to the extensive of crowd and bring to the mankind.The direct symptom of diabetes is hyperglycemia and glucose in urine.The later stage of diabetes can bring a lot of complication, for example, and concurrent cardio cerebrovascular affection: arteriosclerosis, hypertension, apoplexy, myocardial infarction etc.; Nephridial tissue pathological changes: kiney edema, urine protein, renal failure etc.; Ocular tissue's pathological changes: glaucoma, cataract, retinopathy etc.; Nervous tissue pathological change: neural paralysis, sexual dysfunction, extremity are insensitive etc.; Gastrointestinal disease: abdominal distention, diarrhoea, constipation etc.; The foot pathological changes: foot is ice-cold, the difficult healing of intermittent claudication, wound, muscular tissue necrosis etc.In addition, ND hyperglycemic patients is state occurred frequently especially, only just there is people more than 100,000,000 in China, it is exactly diabetes that the state of an illness of hyperglycemic patients continues development, so the medicine and the health food of development blood sugar regulation, blood pressure and blood fat are regulated hyperglycemia, hypertension, hyperlipidemia, prevent diabetes to the mankind and prevented that diabetic complication has certain realistic meaning.
The medicine of present domestic blood sugar regulation or health food have kind more than 30, are divided into eight big classes: 1, insulin; 2, biguanides; 3, sulfonylurea drugs; 4, alpha-glucosidase inhibitor; 5, with the Fructus Momordicae charantiae extract be the health food of main regulation blood glucose.As sharp prestige board Kang Li relieving capsule, Charantin capsule, with spring hall balsam pear lozenge, bitterness and happiness health, Yi Yin board Tang Li buccal tablet etc., the staple market of this series products at home; 6, with the trivalent chromium compound be the health food of main regulation blood glucose.As pyridine acid chromium salt, chromium yeast, Tang An board Tang An milk powder, green as blue Tang Yiganning capsule, the neat good milk powder of prunus mume (sieb.) sieb.et zucc. pancreas power, imperial red board sugar reducing milk powder, rich and honour happy capsule, sugar reducing milk powder, sugared happy recovery oral liquid, day your board of chin or cheek fall together Tang's soft capsule, glycolipid recovery oral liquid etc.This series products is more popular abroad; 7, with the animals and plants polysaccharide be the health food of main regulation blood glucose.But as the safe JIDE rubber of pul capsule, high department board blood sugar lowering noodles, golden melon cream, Shan Laite oral liquid for decreasing blood sugar, the refreshing oral liquid of bean king, neat power blood-sugar reducing tea etc.; 8, with the Chinese herbal medicine be the health food of main regulation blood glucose, but decide the health sheet, prolong the easypro capsule of board in age, the fragrant blood-sugar reducing tea of product, magnificent xylosic alcohol powder, refreshing leaf board blood-sugar reducing tea, hypoglycemic powder treasure etc. as bright power board hundred sugared plain films, Tang An board Jin Tangan sheet, middle section board honeybee curing capsule, holy eagle Chinese Kang Fen, level land board Condar Antang capsule, the sugared power Yiganning capsule of the U.S. board of wound, the thin beautiful tea of thin beautiful board, day name of tune sugar.
In the medicine or health food of above-mentioned blood sugar regulation, insulin has type i diabetes to be alleviated and blood sugar reducing function; Biguanides and sulfonylurea drugs have type ii diabetes to be alleviated and blood sugar reducing function; Alpha-glucosidase inhibitor is the new antidiabetic drug of releasing, and the main carbohydrate inversion that presses down becomes monosaccharide, reduces the absorption of human body to sugar.More than four class antidiabetic drug systems marks do not make this.So medically often say: " in case suffer from diabetes, must take medicine all the life " illustrates that the medicine of commercially available treatment diabetes can only play the purpose of relief of symptoms, can not effect a radical cure, particularly the complication that diabetes are caused is powerless especially, and therefore, the disability rate of diabetes and mortality rate are very high.In addition, the normal phase is taken said medicine, all can produce toxic and side effects to liver and kidney.With the Fructus Momordicae charantiae is the health food of feedstock production, has the effect of blood sugar regulation, but does not have the effect of blood pressure regulation, blood fat, and most of hyperglycemia patient also suffers from hypertension and hyperlipidemia disease except that suffering from the hyperglycemia disease; In addition, its complication of can not prevent diabetes causing.With the trivalent chromium compound is the health food of main regulation blood glucose, the quantity of Insulin receptor INSR increases the combination rate of insulin and receptor, but pancreatic beta cell is not had repair in the somatic cell of energy promote people, be only applicable to the type ii diabetes people and take, can not prevent and treat diabetic complication.With the animals and plants polysaccharide is the health food negligible amounts of main regulation blood glucose, they only can reduce the absorption of human body to sugar, hyperglycemia is had certain regulating action, but clinical test results shows, its blood sugar regulation effect than with Fructus Momordicae charantiae be advocate peace poor based on the health food of trivalent chromium compound.Chinese herbal medicine Radix Puerariae, Radix Polygoni Multiflori, Cortex Cinnamomi, Rhizoma Dioscoreae, Poria, Herba Lophatheri, Semen Coicis, Bulbus Lilii, Fructus Schisandrae Chinensis, Radix Glycyrrhizae, Radix Panacis Quinquefolii etc. blood glucose is had certain regulating action, but treatment cycle are longer, the generation of restive complication and development.Middle section board honeybee curing capsule adopts propolis and Ganoderma preparation, though propolis has blood sugar regulation and the effect of preventing and treating complication, yet there are no the report that Ganoderma has the blood sugar regulation effect clinically.Existing blood-sugar lowering type health-care food has certain regulating action to blood glucose, but does not have the comprehensive function of blood pressure regulation and blood fat, and most of products decrease to organize to disease does not all have repair, can not prevent diabetes and diabetic complication, and can not treating both the principal and secondary aspects of a disease.Therefore, also not having at present can blood sugar regulation, blood pressure and blood fat, again can prevent diabetes and the medicine and the health food of complication.
Summary of the invention the objective of the invention is to overcome the deficiency of above technology, and the medicine or the health food tablet of a kind of blood sugar regulation, blood pressure, blood fat and energy prevent diabetes and complication thereof is provided.
Propolis mainly contains flavonoid, terpenes, organic acid, phenol, aldehyde, ketone, ester, ether, enzyme, vitamins, trace element and other material such as several amino acids, polysaccharide, steroid etc.The main component Flavonoid substances of propolis can increase the elasticity of blood vessel wall, reduce vascular fragility and unusual permeability, blood sugar lowering, blood fat and blood pressure, but terpene compound two-ways regulation blood glucose, blood pressure lowering etc., and disease is decreased tissue have repair and regeneration.
The Fructus Momordicae charantiae nature and flavor are cold, have heat-clearing and toxic substances removing, nourish strong, effects such as blood sugar lowering.The composition that extracts from Fructus Momordicae charantiae has glucokinin, Charantin, Charantin (F, G, T), uracil, cupreol, daucosterol, multivitamin, phytoprotein etc.; The composition that extracts from seed has Charantin (A, B, C, D), momordica lectin element, momordica charantia inhibitor, ribosome, vicine, trehalose, aminoacid, MAP30, P albumen etc.Glucokinin in Charantin and the Fructus Momordicae charantiae is the effective ingredient of balsam pear hypoglycemic.Test shows that the bioactive ingredients in the Fructus Momordicae charantiae can prevent that blood glucose is too high, activate β emiocytosis insulin, and glucokinin has the effect of para-insulin sample.Exist non-single multiple hypoglycemic activity composition in the Fructus Momordicae charantiae, and have collaborative blood sugar reducing function between the various sugar-lowering components, be worth so Fructus Momordicae charantiae, has higher medicinal and health care as the blood sugar lowering plant of integration of edible and medicinal herbs.
Radix Salviae Miltiorrhizae bitter in the mouth cold nature has promoting blood circulation to restore menstrual flow, the silt pain relieving of dispelling, the relieving restlessness that clears away heart-fire, removing heat from blood disappear effects such as pain.Effective ingredient mainly contains fat-soluble tanshinone and soluble salvianolic acid constituents in the red sage root.In addition, also contain compositions such as flavonoid, triterpenes and sterol.Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, and blood pressure lowering, blood sugar lowering, the effect of microcirculation improvement all has certain curative effect to cardiovascular system, blood system, central nervous system, digestive system disease.
The Folium Mori nature and flavor are sweet, flat, cold, Folium Mori contain flavonoid, aminoacid, 25-45% crude protein, 20-25% carbohydrate, 5% crude fat and abundant potassium, calcium and vitamin C, B
1, B
2, the material wanted of needed by human body such as trace copper, zinc, boron, manganese etc., plumage dolineone and globulariacitrin, Cortex Mori glycoside, chlorogenic acid, folic acid, Fumaric acid, meso creatine, phytoestrogen.The test of pesticide effectiveness proves that Folium Mori energy blood sugar lowering, blood pressure lowering, defying age, the accumulation of inhibition fat, inhibition thrombosis generate, and inhibition intestinal toxic bacterial reproduction suppresses oxygen-derived free radicals and generates, and the most outstanding function is to prevent and treat diabetes.
Folium Hippophae is a kind of contain multivitamin, trace element, aminoacid and biological active substances, as contain phospholipid, 13%-19% protein, 2.70%-5.26% fat, 16.50%-25.52% sugar, every 100g Folium Hippophae about 0.5% and contain flavone compound and be 976mg, also contain and suppress tumor promotion material serotonine in addition, as a kind of neurotransmitter the interior environment of the blood pressure of human body, body temperature, body and hormone etc. all there are important regulatory role.It contains coumarin substances and has the blood capillary of enhancing and hemostasis anticoagulation, is the triterpene substance of main representative with the maloic acid, has expanding cardiovascular, cerebrovascular effect, promotes blood microcirculation, brings high blood pressure down and blood glucose.
The medicine of a kind of blood sugar regulation, blood pressure and blood fat that this patent is narrated or health food tablet, form by raw materials such as Fructus Momordicae charantiae, propolis, Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae, the content of each composition wherein: Fructus Momordicae charantiae extract dry powder is 350-500 part, refining propolis is 250-300 part, and Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae mixed extract dry powder are 200-400 part.
The preparation method characteristic of the medicine of a kind of blood sugar regulation, blood pressure and blood fat or health food tablet is:
A, Fructus Momordicae charantiae after washing, dry surface moisture, after the pulverizing, put into extraction pot, the water that adds 2～3 times extracts 1h at 50 ℃～60 ℃, filters, filtering residue is repeated to extract once according to last method, merges filtrate twice, at 60 ℃ of concentrating under reduced pressure to 8 ° of Be～12 ° Be of Baume degrees.When inlet temperature is 150 ℃, concentrated solution is sprayed into dry powder;
B, pick up remove former propolis impurity after, deleading adds 3～5 times 95% ethanol, extracts 2h at 50 ℃～60 ℃, filters, and filtering residue is repeated extraction once according to last method, merges filtrate twice, removes ethanol at 50 ℃ of concentrating under reduced pressure, must make with extra care propolis;
C, pick up except that behind the impurity in Radix Salviae Miltiorrhizae, Folium Mori and the Folium Hippophae, the washing, the oven dry.Take by weighing Radix Salviae Miltiorrhizae respectively, Folium Mori, Folium Hippophae, mix 95% ethanol that the back adds 3～5 times, extract 2h at 50 ℃～60 ℃, filter, filtering residue is repeated to extract once by last method, merge filtrate twice, to 10 ° of Be～15 ° Be of Baume degrees, when inlet temperature is 150 ℃, concentrated solution is sprayed into dry powder at 60 ℃ of concentrating under reduced pressure then;
D, take by weighing the above-mentioned Fructus Momordicae charantiae extract dry powder for preparing and Radix Salviae Miltiorrhizae, Folium Mori, Folium Hippophae three flavor Chinese medicine extract dry powder and refining propolis by formula proportion; add the ethanol mix homogeneously; granulate with 40 eye mesh screens; 50 ℃ of baking temperatures; on pelletizing machine, use 40 orders-80 eye mesh screen granulate; after adding the moderate lubrication agent, tabletting promptly gets product.
With Fructus Momordicae charantiae, propolis, Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae is the medicine or the health food tablet of raw material development, the prescription science, compatibility is reasonable, technology is easy, the extraction ratio height, integrated various materials of effective ingredients have kept the activity of various compositions, have synergism, comprehensive function and booster action between each composition.Blood sugar regulation, blood pressure and blood fat effectively; Be applicable to that I, type ii diabetes patient take, and have tangible effect preventing and treating diabetes and diabetic complication, and without any side effects.
The specific embodiment prepares the batching of above-mentioned tablet 1kg: Fructus Momordicae charantiae extract dry powder 350g-500g, refining propolis 250g-300g, Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae mixed extract dry powder 200g-400g part.
Its concrete method for making is as follows:
(1), Fructus Momordicae charantiae is cleaned the clay contaminated thing with clean demineralized water, dry surface moisture, take by weighing 100kg, after the pulverizing, put into extraction pot, the water that adds 2～3 times, extract 1h at 50 ℃～60 ℃, filter, filtering residue is repeated to extract once according to last method again, merging extracted twice liquid, is 8 ° of Be～12 ° Be at 60 ℃ of concentrating under reduced pressure to Baume degrees.When inlet temperature is 150 ℃, concentrated solution is dusted, make dry powder 5.2kg;
(2), remove silt impurity in Radix Salviae Miltiorrhizae, Folium Mori and the Folium Hippophae respectively, clean up with clean demineralized water, after 80 ℃～90 ℃ oven dry, take by weighing respectively and put into extraction pot after Radix Salviae Miltiorrhizae 20kg, Folium Mori 30kg and Folium Hippophae 30kg mix, the water that adds 5～10 times of total amounts, extract 2h at 50 ℃～60 ℃, filter, filtering residue is repeated to extract once according to last method again, merge extracted twice liquid, is 10 ° of Be～15 ° Be at 60 ℃ of concentrating under reduced pressure to Baume degrees, when inlet temperature is 150 ℃ concentrated solution is dusted, and makes dry powder 50kg;
(3), take by weighing the former propolis of 100kg, put into extraction vessel after picking up the removal of impurity, deleading adds 95% ethanol of 3～5 times of total amounts, extracts 2h at 50 ℃～60 ℃, filters, and filtering residue is repeated to extract once according to last method again.Merge extracted twice liquid, remove ethanol, make refining propolis 34kg at 50 ℃ of concentrating under reduced pressure;
Take by weighing Fructus Momordicae charantiae extract dry powder 350g, Radix Salviae Miltiorrhizae, Folium Mori, the Folium Hippophae three flavor Chinese herbal medicine extract dry powder 400g and the refining propolis 250g of above-mentioned preparation; add 95% ethanol 80ml mix homogeneously; granulate with 40 eye mesh screens; then 50 ℃ of dryings; on pelletizing machine with 40 orders～80 mesh sieve granulate; preparation 1kg granule adds the moderate lubrication agent, suppresses 2000 (0.5g/ sheets), bottling, packing, warehouse-in after checking.
Take by weighing Fructus Momordicae charantiae extract dry powder 500g, Radix Salviae Miltiorrhizae, Folium Mori, the Folium Hippophae three flavor Chinese herbal medicine extract dry powder 200g and the refining propolis 300g of above-mentioned preparation; add 95% ethanol 80ml mix homogeneously; granulate with 40 eye mesh screens; then 50 ℃ of dryings; on pelletizing machine with 40 orders～80 eye mesh screen granulate; preparation 1kg granule adds the moderate lubrication agent, is pressed into 2000 (0.5g/ sheets), bottling, packing, warehouse-in after checking.
The medicine of above-mentioned this blood sugar regulation, blood pressure and blood fat or health food tablet are through patient's probationary certificate, blood sugar regulation, blood pressure and blood fat effect are obvious, be suitable for I type, type ii diabetes patient and hyperglycemic patients, have no side effect, and the complication that can prevent diabetes causes, total effective rate is more than 98%, and cure rate is more than 80%.
Case:
Old * *, the address: the Yang Ling of Shaanxi Province, the male, 46 years old, suffered from diabetes 11 years, take above-mentioned tablet after 20 days, blood sugar recovery is normal, and health is rehabilitation now.
Open * *, the address: the Baoji, Shaanxi province, the male, 72 years old, suffered from diabetes 16 years, take above-mentioned tablet after 50 days, eliminate polyuria and thirsty disease.
Pay * *, the address: the Shenzhen City, Guangdong Province, the male, 76 years old, suffer from hyperglycemia, take above-mentioned tablet after 50 days, blood sugar recovery is normal.
Claims (2)
1. the medicine of a blood sugar regulation, blood pressure and blood fat or health food tablet, it is characterized in that making by Fructus Momordicae charantiae, propolis, Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae raw material, during it is formed, Fructus Momordicae charantiae extract dry powder is 350-500 part, refining propolis is 250-300 part, and Radix Salviae Miltiorrhizae, Folium Mori and Folium Hippophae mixed extract dry powder are 200-400 part.
2. the preparation method of medicine according to claim 1 or health food tablet is characterized in that;
A, Fructus Momordicae charantiae dry surface moisture after washing, pulverize, and put into extraction pot, add 2～3 times water, extract 1h at 50 ℃～60 ℃.Filter.Filtering residue is repeated to extract once according to last method.Merge filtrate twice, at 60 ℃ filtrate decompression being concentrated to Baume degrees is 8 ° of B é～12 ° B é, when inlet temperature is 150 ℃ concentrated solution is sprayed into dry powder;
B, pick up remove former propolis impurity after, deleading adds 3～5 times 95% ethanol, extracts 2h at 50 ℃～60 ℃, filters, and filtering residue is repeated extraction once according to last method, merges filtrate twice, removes ethanol at 50 ℃ of concentrating under reduced pressure, must make with extra care propolis;
C, pick up except that behind the impurity in Radix Salviae Miltiorrhizae, Folium Mori and the Folium Hippophae, the washing, the oven dry, take by weighing Radix Salviae Miltiorrhizae, Folium Mori, Folium Hippophae respectively, mix 95% ethanol that the back adds 3～5 times, extract 2h at 50 ℃～60 ℃, filter, filtering residue is repeated to extract once by last method, merge filtrate twice, at 60 ℃ filtrate decompression being concentrated to Baume degrees is 10 ° of B é～15 ° B é, when inlet temperature is 150 ℃ concentrated solution is sprayed into dry powder then;
D, the Fructus Momordicae charantiae extract dry powder Radix Salviae Miltiorrhizae that takes by weighing above-mentioned preparation, Folium Mori, Folium Hippophae three flavor Chinese medicine extract dry powder and refining propolis; add the ethanol mix homogeneously; granulate with 40 eye mesh screens; 50 ℃ of baking temperatures; on pelletizing machine, use 40 orders-80 eye mesh screen granulate; add the moderate lubrication agent, tabletting is a finished product.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315291B (en) * | 2013-05-20 | 2015-04-15 | 蚌埠市楠慧川味食品厂 | Dried balsam pear for reducing blood sugar |
| CN104523829B (en) * | 2014-12-18 | 2018-06-01 | 威海百合生物技术股份有限公司 | A kind of propolis Radix Salviae Miltiorrhizae health food |
| CN105533596A (en) * | 2015-12-14 | 2016-05-04 | 山东天地健生物工程有限公司 | Propolis, radix salviae miltiorrhizae and ginkgo leaf capsules and preparation method thereof |
| CN108157960A (en) * | 2018-02-09 | 2018-06-15 | 山西省林业科学研究院 | A kind of preparation method of sea-buckthorn hypoglycemic lozenge |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1224614A (en) * | 1998-01-24 | 1999-08-04 | 倪德贵 | Medicine for preventing and curing cardiac and cerebral vascular diseases and its preparation |
| CN1296830A (en) * | 2000-11-24 | 2001-05-30 | 徐忠廷 | Chinese-medicinal capsule for treating diabetes |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1224614A (en) * | 1998-01-24 | 1999-08-04 | 倪德贵 | Medicine for preventing and curing cardiac and cerebral vascular diseases and its preparation |
| CN1296830A (en) * | 2000-11-24 | 2001-05-30 | 徐忠廷 | Chinese-medicinal capsule for treating diabetes |
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