CN102380051B - Medicinal steamed bread for treating diabetes - Google Patents
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Abstract
The invention discloses medicinal steamed bread for treating diabetes. Every 100 grams of steamed bread contain 3-10 percent by weight of medicament which is prepared from the following raw materials in parts by weight: 10-6 parts of Chinese yam, 10-5 parts of gorgon euryale seed, 10-3 parts of fragrant solomonseal rhizome, 8-3 parts of common anemarrhena, 8-3 parts of Mongolian snakegourd root, 8-3 parts of sophora flower, 8-2 parts of sealwort, 8-2 parts of corn stigma, 6-2 parts of dwarf lilyturf root, 6-2 parts of asparagus, 6-2 parts of propolis, 6-1 parts of curcumin and 6-1 parts of mulberry leaf. The medicinal steamed bread can be used for relieving, improving, preventing and treating diabetes type I and diabetes type II, so that the aims of relieving, improving, preventing and treating with medicinal foods are achieved.
Description
Technical field
The present invention relates to a kind of medicine and medicinal steamed bread for treating diabetes for the treatment of diabetes.
Background technology
Diabetes are to cause human dead the third-largest disease, and present global patient surpasses 200,000,000 people, and China patient nearly 2,000 ten thousand.In recent years, the sickness rate cumulative year after year of diabetes has a strong impact on people's life even threat to life, has brought heavy financial burden for society and individual, has become a more and more serious public health problem of countries in the world.
The synthetic antidiabetic drug untoward reaction of having gone on the market at present is serious, and price is more expensive.Acting on the chemicals that chronic complicating diseases of diabetes may target spot only has several (such as protein glycosylation inhibitor aminoguanidine, aldose reductase inhibitor fidarestats etc.), still is in during each clinical trial phase carries out, and also can not meet clinical needs far away.Motherland's medical science is having long history and significant curative effect aspect treatment diabetes and the complication thereof, seek effective ingredient or carry out on this basis structure of modification to obtain better medicine from Chinese herbal medicine, and DEVELOPMENT PROSPECT is very wide.
At present a lot of for the clinical report of the drug food of TCM therapy of diabetes, still, many medicated diet staple foods exist metering to be difficult to some factors of instability such as control, collocation are strict, mouthfeel is not good enough.Therefore, seeking a kind of abundant, diversified drug food of TCM method of mouthfeel of can easyly measuring, arrange in pairs or groups, is the key issue that present diabetes dietary therapy of Chinese medicine needs to be resolved hurrily.
Summary of the invention
One of the present invention purpose is to provide a kind of medicine that can alleviate, improve, prevent and treat diabetes.
The present invention's two purposes are to provide a kind of and integrate food, have the medicinal steamed bread for treating diabetes that contains medicine that alleviates, improves, prevents and treat diabetes, and it can be used for alleviating, improve, preventing and treat type i diabetes, type ii diabetes.
The object of the present invention is achieved like this, the medicine of described treatment diabetes, and it is to be made by the raw material of following weight proportioning:
10～6 parts of Rhizomadioscoreae, 10～5 parts of Semen Euryaless, 10～3 parts of Rhizoma Polygonati Odorati, 8～3 parts of the Rhizoma Anemarrhenaes, 8～3 parts of Radix Trichosanthis, 8～3 parts in Flos Sophorae, 8～2 parts of Rhizoma Polygonatis, 8～2 parts of Stigma Maydis, 6～2 parts of Radix Ophiopogonis, 6～2 parts of Radix Asparagis, 6～2 parts of propolis, 6～1 parts of curcumins, 6～1 parts on Folium Mori;
The object of the present invention is achieved like this, the medicinal steamed bread for treating diabetes of described treatment diabetes, it is characterized in that per 100 grams contain the medicine (can make by embodiment 2 or 3 methods) of being made by Rhizomadioscoreae, Semen Euryales, Rhizoma Polygonati Odorati, the Rhizoma Anemarrhenae, Radix Trichosanthis, Flos Sophorae, Rhizoma Polygonati, Stigma Maydis, Radix Ophiopogonis, Radix Asparagi, propolis, curcumin and Folium Mori of 3-10% percentage by weight in the steamed breads, described steamed bread with medicine routinely technique is made into by flour;
Described medicine is to be made by the raw material of following weight proportioning:
10～6 parts of Rhizomadioscoreae, 10～5 parts of Semen Euryaless, 10～3 parts of Rhizoma Polygonati Odorati, 8～3 parts of the Rhizoma Anemarrhenaes, 8～3 parts of Radix Trichosanthis, 8～3 parts in Flos Sophorae, 8～2 parts of Rhizoma Polygonatis, 8～2 parts of Stigma Maydis, 6～2 parts of Radix Ophiopogonis, 6～2 parts of Radix Asparagis, 6～2 parts of propolis, 6～1 parts of curcumins, 6～1 parts on Folium Mori;
The function of each component of the present invention of record is as follows in detail in pharmacopeia:
1) Rhizomadioscoreae: function cures mainly: supplementing QI and nourishing YIN, spleen reinforcing lung kidney, treating spontaneous emission and leukorrhagia.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.2) Semen Euryales has the effects such as convergence controlling nocturnal emission with astringent drugs, is applicable to chronic diarrhea and frequent micturition, emission, and the women is with many soreness of waist etc.3) Rhizoma Polygonati Odorati, effect: nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain.Pharmacological action: these product have the laboratory animal of promotion antibody and generate, improve phagocytic percentage and the phagocytic index of macrophage, promote interferon synthetic, suppress growth of bacillus tubercle, blood sugar lowering, blood fat reducing is alleviated atherosclerotic plaque and is formed, and makes peripheral blood vessel and coronary dilation, prolong hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.Also has the effect of similar adrenocortical hormone sample.4) Rhizoma Anemarrhenae, effect and application: 1. clearing away heat-fire---external treatment fever caused by exogenous pathogenic factors, high hot excessive thirst, the treatment by oral administration of medicines cough due to lung-heat, gastric heat is quenched one's thirst.2. promote the production of body fluid and moisturize---the xeropulmonary cough; The dryness of the intestine constipation; Osteopyrexia and fever.5) Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, is clearing away heat-fire class medicine, and its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For the treatment diabetes, commonly used it and drugs for nourishing yin are used, to reach the effect for the treatment of both the principal and secondary aspects of a disease.6) Flos Sophorae, the traditional Chinese medical science are thought its bitter in the mouth, cold nature, return liver, large intestine channel; Enter blood and hold back and fall, body is slightly loose; Has cooling blood for hemostasis, the effect of purging liver-fire; Cure mainly discharging fresh blood stool, hemorrhoidal bleeding, dysentery, hematuria, stranguria with blood, metrorrhagia is spitted blood, epistaxis, liver-fire headache, conjunctival congestion and swelling pain, sore throat, aphonia, ulcer sores.And from the angle of doctor trained in Western medicine, it (is rutin, Rytub), the material such as Quercetin (Quercetin), tannin, sophoradiol (sophoradiol), vitamin A that Flos Sophorae contains rutin.Rutin can be improved the function of blood capillary, keeps the normal resistance of blood capillary, prevent because of capillary fragility excessive, hemorrhage, the hypertension that permeability is too high to be caused, diabetes, can preventing of clothes is hemorrhage.7) Rhizoma Polygonati, Rhizoma Polygonati is used as medicine with rhizome.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.8) Stigma Maydis, " Zhejiang traditional herbal medicine " controls diabetes: Semen Maydis palpus one or two.Decoction.Modern pharmacological research shows that Stigma Maydis contains a large amount of potassium nitrate, vitamin K, sitoesterol, stigmasterol and a kind of volatile alkaloid.The effects such as diuresis, blood pressure lowering, blood sugar lowering, hemostasis, function of gallbladder promoting are arranged.9) Radix Ophiopogonis, can improve immunologic function; Various bacteria there is inhibitory action; Can strengthen the pituitary adrenal system function, improve the organism adaptation ability; Arrhythmia and the peripheral vascular effect of expansion are arranged; Can improve hypoxia-bearing capability; Hypoglycemic activity is arranged.Purposes: be used for lung-dryness syndrome due to deficiency of YIN, cough with ropy sputum; Thermal burn stomach-Yin or deficiency of stomach-YIN, dry throat and mouth, constipation with dry stool; Deficiency of heart-yin or heart channel have heat, dysphoria and insomnia, red tongue with a little fluid.Contain asparagine, phlegmatic temperament, cupreol, several amino acids.10) Radix Asparagi has antitussive, phlegm-dispelling functions; Various bacteria there is inhibitory action; Anti-tumor activity is arranged.[purposes] is used for deficiency of YIN lung-heat, and dry cough expectorant is sticking, or spitting of blood; Hyperactivity of fire caused by deficiency of YIN, hectic fever night sweat, seminal emission; Interior-heat is quenched one's thirst; The dryness of the intestine constipation.11) propolis, propolis are the real jinxs of diabetes.The diabetics hyperglycemia mainly is because hypoinsulinism causes due to sugar, fat, protein metabolism disorder, the nutrient utilization imbalance, often shows as clinically: polydipsia, polyphagia, polyuria.Insulin is by the pancreatic tissue cell mass: the protein hormone of beta Cell of islet secretion, regulate metabolism utilization and the storage of sugar, fat, protein three major nutrient.Long-term hyperglycemia continues to stimulate to beta Cell of islet, the extracellular fluid osmotic pressure increases, intracellular fluid outwards runs off, and causes its dysfunction even nonfunction, and insulin secretion is fewer and feweri, cause that glucose in urine increases, carbohydrate metabolism disturbance, the fat in the body tissue, protein decompose energy supply, cause patient's emaciated physique, with fatigue and weak, cause the organ-tissues such as eye, kidney, blood vessel, heart to carry out sexually transmitted disease (STD) and become.12) curcumin is mainly used in the painted of the products such as intestinal based article, canned food, beans spiced and stewed food in food production.Medical research shows that curcumin has the effects such as blood fat reducing, antitumor, antiinflammatory, function of gallbladder promoting, antioxidation.13) Folium Mori, function: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving.
(1) nutritional labeling and the edible function that have of each component of the present invention is as follows:
1) Rhizomadioscoreae is the confessed excellent tonic products of people.It contains the compositions such as protein, saccharide, vitamin, fat, choline, amylase, mucus juice.Also contain the indispensable inorganic salt of human body and the trace element such as iodine, calcium, ferrum, phosphorus, and the content of phosphorus is Duoed one times than Radix Ipomoeae, Duos two times than Rhizoma Solani tuber osi.Tuber contains Saponin, phlegmatic temperament, choline, starch (16%), glycoprotein and free amino acid, also contain only wooden fork element (d-Abscisin II), polyphenol oxidase, vitamin C (5 milligrams of %), 3,4-dihydroxy benzenes ethamine contains mannan (Mannan) and phytic acid (Phytic acid) in the mucus.The Japan Rhizoma Dioscoreae contains dioscin (Dioscin), and its glycoside unit is diosgenin, also is the composition that the yam tuber often contains.Rhizome contains dopamine (dopamine), Rhizoma Dioscoreae alkali (batatasine, 0.025%), acerin II (abscisin II), cholesterol (cholesterol), ergosterol (ergosterol), campesterol (camps-terol), cupreol; Other contains free amino acid, and glucoproteid (glycopro-teins), and hydrolysis produces the several amino acids such as lysine, glutamic acid, serine.In addition, still starch-containing 20%-30%, tannin, phlegmatic temperament, glycoprotein, polyphenol oxidase etc.Contain mannan (mannan), phytic acid (phytic acid), 3 in the mucus, 4-dihydroxy benzenes ethamine, allantoin (allantoin).Bulbilus dioscoreae also contains batatasins I (batatasin I).
2) Semen Euryales, food therapy value, the seed of Nymphaeceae aquatic herbaceous plant Gorgon euryale.Claim again Semen Euryales, aquatic Caput Gallus domesticus, the thorn seedpod of the lotus in fact.Gorgon euryale is distributed in the ground such as China is Central-South, southwestern, East China, northeast.Extract mature fruit autumn, remove outer peel, take out seed, the crushing duricrust is got core and is dried usefulness.Semen Euryales has a lot of nutritional labelings such as carbohydrate, fat, protein, crude fibre, calcium, phosphorus, ferrum etc.; Semen Euryales is described as " Radix Ginseng in the water ", and strengthening the spleen and nourishing the stomach is arranged, the effect of supplementing the kidney to control the nocturnal.
3) Rhizoma Polygonati Odorati, these product again can nourishing stomach-YIN, and clearing away stomach-heat cures mainly the dry the moon that injures one's stomach, dry mouth and tougue, inappetence, normal and the same usefulness of the product such as Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae); Control quenching one's thirst that gastric heat Tianjin hinders, can with the same usefulness of product such as Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Radix Trichosanthis, can receive altogether the effect that clearing stomach is promoted the production of body fluid.Root stock contains Rhizoma Polygonati Odorati mucopolysaccharide (odoratan), by D-Fructose, and D-MANNOSE, D-Glucose and galacturonic acid form, and mol ratio is 6: 3: 1: 1.5; Rhizoma Polygonati Odorati levan (polygonatum-fructan) A, B, C, D, sugar consist of fructose (%): glucose (%) (97.5: 2.6,96.2: 3.8,95.3: 4.8,90.4: 9.6), AzeOH (azetidine-2-carboxylic acid).Also contain Rhizoma Polygonati spiral shell sterol (polyspirostanol) Poa, Rhizoma Polygonati spiral shell sterol glycoside (poly-spirostanoside) Pob, Poc, PO1, PO2, PO3, PO4, PO5, Rhizoma Polygonati furan sterol glycoside (polyfuroside), the steroids such as Rhizoma Polygonati furan sterol glycoside Poc, Pod, PO6, PO7, PO8 and PO9.PO2 and Pob have same structure, are 25-R, S three-dimensional heterogeneous mixture, and just R/S ratio is different; PO3 is the extremely mixture of 25-R of Poc.N-trans-ferulaic acid cheese amide (N-trans-feruloyl tyramine, I), 5 hydroxymethyl furfural (5-hydroxymethy l-2-furfural, II), (-)-syringaresinol [(-)-syringaresinol, III), 3 β, 14 alpha-dihydroxy-s-(25S)-spirostane alcohol-5-alkene [3 β, 14 α-dihydroxy-(25S)-spirost-5-ene, IV) and cupreol (β-sitosterol, V).The conclusion Compound I is to separate first to obtain from Polygonatum, and Compound I I, III separate to obtain first from Rhizoma Polygonati Odorati.The effect of Rhizoma Polygonati Odorati:
1, the steroid glycoside that contains of Rhizoma Polygonati Odorati is similar to effect and the Herba Convallariae preparation of cardiac muscle.The Rhizoma Polygonati Odorati glycocide has cardiotonic to isolated frog heart, and the effect of Rhizoma Polygonati Odorati decoct and Rhizoma Polygonati Odorati glycocide are similar.
2, Rhizoma Polygonati Odorati extractum lumbar injection can strengthen the burned mice Peritoneal macrophages Phagocytosis, improves the Hemolysin level, improves splenocyte to the breeder reaction of ConA.
4) Rhizoma Anemarrhenae separates obtaining 20 chemical compounds from the Asphodeloides Bge Rhizome ethanol extraction, adopt spectrographic method and chemical method to identify the wherein structure of 15 chemical compounds; Be respectively nonacosanol (I), octacosane acid blend (II), cupreol (III), daucosterol (IV), chinaroot greenbrier sapogenin (V), markogenin (VI), zhimusaponin AIII (VII), zhimusaponin BI (VIII), zhimusaponin BIII (IX), 2,6,4 '-trihydroxy-4-methoxyl group benzoyl ketone (X), precious leaves of pulse plants glycoside I (XI), icariine-I (XII), Mengiferin (XIII), 7-O-grape glucityl Mengiferin (XIV), timobiose (X V). wherein compound VIII is new natural product, Compound I, XI, XII, the known compound of XIV for from the Rhizoma Anemarrhenae, getting first.
5) Radix Trichosanthis, dietary function; Also have hitodesterol and glucoside thereof, Δ in the Radix Trichosanthis
7-stigmasterol and glucose leather thereof, Palmic acid, (Z, Z)-9, the acid of 12-18 carbon dienes, (Z, Z, Z)-cis 9,12,15-oc-tadecatrienoic acid and Δ
7The acid of-stigmastene waits composition.Referring to document: external medical plant amedica fascicle the 1st phase of the 18th volume in 2003.From bright root juice, isolate trichosanthin (TCMLIBicho-santhin).Also obtain several amino acids: α methylol serine (α-hydrox-ymethylserine), aspartic acid (aspartic acid), citrulline (thrionine), serine (serine), glutamic acid (glutamic acid), threonine (threonine), glycine (glycine), valine (valine), tyrosine (tyrosine), phenylalanine (pheny-lalanine), histidine (histidine), lysine (lysine), arginine (arginine), ornithine (ornithine) and peptide class (peptide), ribose (ribose), xylose (xylose), arabinose (arabinose), glucose (glucose), galactose (galac-tose) etc.; Contain the polysaccharide with blood sugar lowering effect; Radices trichosanthis polysaccharide (TCMLIBichosan) A, B, C, D, E; Rhizome contains and has anticancer and immunocompetent polysaccharide, is by glucose, galactose, and fructose (fructose), mannose (mannose), xylose and epsilon protein form.Bright root also contains 7-stigmastene-3 β-alcohol (stigmasta-7-stigmastene-3 β-alcohol-3-O-β-D-glucopyanoside (stigmasta-7-en-3 β-3-O-β-D-glucopyranoside), bryonia alcohol acid (bryonolic acid), Cueurbitacin (cucur-bitacin) B and D, 23,24-dihydro Cueurbitacin (23,24-dihydrocucurbitacin) B.
6) Flos Sophorae, edibility; Semen Phaseoli Saponin (azukisaponin) I, II, V, soyasaponins (soyasaponin) I, III, Flos Sophorae Saponin (kaikasaponin) I, II, III.
Also contain flavonoid: Quercetin (quercetin), globulariacitrin (rutin), isorhamnetin (isorhamnetin), isorhamnetin-3-rutinoside (isorhamnetin-3-rutinoside), kaempferol-3-rutinoside (kaempferol-3-rutinoside).Contain again betulin (betulin), sophoradiol (sophoradiol).
Contain lauric acid (lauric acid) in the caul-fat, dodecenoic acid (dodecenoic acid), myristic acid (myristic acid), tetradecenoic acid (tetradecenoic acid) tetracosandienoic acid (teradecadienoic acid), Palmic acid (palmitic acid), hexadecenoic acid (hexadecenoic acid), stearic acid (stearic acid), octadecadienoic acid (octadecadienoic acid), the fatty acids such as ten make carbon trienic acid (octadecatrienoic acid), arachidic acid (arachidic acid) and cupreol (β-sitosterol).Other contains tannin.
7) Rhizoma Polygonati, food therapy value; The root stock of Rhizoma Polygonati contains steroid saponin, has isolated 2 furan steroid enol form Saponins and 2 spirostene alcohol type Saponins.What belong to the former is: 26-O-β-D-glucopyranosyl-22-O-methyl-(25) S-furan steroid-5-alkene-3 β, 26-glycol 3-O-β-lycotetraose glycoside [26-O-β-D-glucopyranosyl-22-O-methyl-25 (S)-furost-5-ene-3 β, 26-diol3-O-β-lycotetraoside] be Herba Polygoni sibirici glycoside A (sibiricoside-A) and 26-O-β-D-glucopyranosyl-22-O-methyl-25 (S)-furan steroid-5-alkene-3 β, 14 α, 26-triol 3-O-β-lycotetraose glycoside [26-O-β-D-glucopyranosyl-22-O-methyl-25 (S)-fruost-5-ene-3 β, 14 α, 26-triol3-O-β-lycotetraoside] i.e. 14 Alpha-hydroxy Herba Polygoni sibirici glycoside A (14 α-hydroxysibiricosideA); What belong to the latter is: [(23S, 25R) spiral shell steroid-5-alkene-3 β, 14 α, 23-triol 3-O-β-lycotetraoside] be that Herba Polygoni sibirici glycoside B (sibiricosideB) and new bus draw time diosgenin-A3-O-β-lycotetraose glycoside (neoprazerigeninA 3-O-β-lycotetraoside).Other contains polygonatum polysaccharide A, B, C, and three's relative molecular mass forms according to mol ratio condensation in 6: 26: 1 by glucose (glucose), mannose (mannose) and galacturonic acid (galacturonicacid) all greater than 200,000; Contain again polygonatum rhizome oligosaccharide A, B, C, relative molecular mass is respectively 1630,862 and 472, is to be formed by fructose (fructose) and glucose 8: 1 in molar ratio, 4: 1 and condensation in 2: 1.
Rhizoma Polygonati contains multiple chemical constituent to the human body beneficial, such as polysaccharide, steroidal saponin, Anthraquinones, alkaloid, cardiac glycoside, lignanoid, vitamin and aminoacid etc.Fatty acid in the Rhizoma Polygonati mainly is linoleic acid, palmitoleic acid, stearic acid, linolenic acid, arachidic acid.The composition of Rhizoma Polygonati volatile ingredient is complicated, the multi-class chemical compounds such as carboxylic acids, aldehydes, alcohols, aromatics, alkanes, anhydride are arranged, wherein mainly contain hexanal, hexenoic acid, hexanol, the relative mass mark is respectively: 29.13%, 14.7%, 4.89%.The aminoacid A wide selection of colours and designs that Rhizoma Polygonati is contained, essential amino acids total content are 1.075g/100g.
8) Stigma Maydis, food therapy value; Fatty oily 2.5%, volatile oil 0.12%, gummy sample material 3.8%, resin 2.7%, bitterness glucoside 1.15%, Saponin 3.18%, alkaloid 0.05%.Also contain cryptoxanthine, vitamin C, pantothenic acid, inositol, vitamin K, sitosterol, stigmasterol, malic acid, citric acid, tartaric acid, oxalic acid etc.In addition, also contain a large amount of potassium nitrate, a-gives birth to quinone.
9) Radix Ophiopogonis, food therapy value; Cupreol (I), 6-aldehyde radical-7-methoxyl group-different flavanone B Radix Ophiopogonis (II), cupreol-β-D-Glucose glycoside (III) and Borneolum Syntheticum glycoside (IV)." quench one's thirst " category of card of the positive diabetes spp traditional Chinese medical science, its pathogenesis, lung-stomach yin deficiency be this, scorching in table very, treat take replenishing YIN and removing heat as rule for the treatment of.According to the Chinese medicine compound for the treatment of type 2 diabetes mellitus and the composition analysis of Chinese patent medicine in the past, accounting for more than 1/2 of Radix Ophiopogonis wherein arranged, and Radix Ophiopogonis as the key medicine for the treatment of " quenching one's thirst ", extensively on the books in the Chinese medicine ancient books and records.This research is extracted Radix Ophiopogonis polysaccharide from Radix Ophiopogonis the single medicinal material, is used for the treatment of the speed property the sent out diabetes model rat that streptozotocin (STZ) brings out, to observe it to the effect of blood glucose in diabetic rats and insulin.Radix Ophiopogonis polysaccharide can obviously suppress the mice hyperglycemia due to glucose, alloxan and the epinephrine, and its mechanism of action may be for reducing alloxan (ALX) to the beta Cell of islet damage or improving the β cell function that damages; Radix Ophiopogonis polysaccharide is the main extract of tuber Radix Ophiopogonis, the property of medicine with Radix Ophiopogonis, very high medical value is arranged, the deferrable blood sugar increasing time, can reduce spontaneous hyperglycemia and rising serum insulin: can reduce blood glucose and glycolated hemoglobin that streptozotocin brings out hyperglycemic rat;
10) Radix Asparagi, food therapy value; Contain Sitosterolum (1); Daucosterol (2); Positive three lauric acids (3), Palmic acid (4), 9 cerotenes (5), Sarsasapogenin (6), diosgenin (7), Sarsasapogenin 30[α L Fructus rhamni (Rhamnus davurica Pall.) pyrans glycosyl (14)] β D glucopyranoside (8), except Sitosterolum, be first and from this plant, get.The external activity experiment shows that chemical compound (8) has antifungal activity and anti-tumor activity.
11) propolis, dietary function; Wherein flavone compound is 7, is accredited as pinostrobin (I), Tectona grandis L. F. Yang Su (II), chrysin (III), galangin (IV), 3-O-acetoxyl group pinobanksin (V), apigenin (VIII), alpinin (IX); Two of caffeic acid ester compounds are accredited as coffee acid benzyl ester (VI) and CAPE (VII); 3 of caffeic acid derivants are accredited as 3,4-dimethoxy-cinnamic acid (X), ferulic acid (XI) and caffeic acid (XII).
12) curcumin, food therapy value; Curcumin is one of a few antioxidant that has simultaneously in a molecule phenolic hydroxyl group and two kinds of antioxidant groups of beta-diketon, and unique conjugated system of the enol-type structure of two phenolic hydroxyl groups and a beta-diketon makes its ability with significant Trapped free radical and ends the antioxidant activity of chain reaction.Studies have shown that in the external body that curcumin can remove ultra-oxygen anion free radical and hydroxyl radical free radical, suppress lipid peroxidation, increase the activity of polyphenoils such as SOD, GSH, GST, GPx etc.Hepatic cholagogic, curcumin energy antagonism CCL, the damaging action that D-galactosamine, peroxide and ionophore are cultivated Rat Primary Hepatocytes, the protection hepatocyte, and the millet straw of rising, glutamate pyruvate transaminase value are reduced respectively, and dose-effect relationship is arranged.Curcumin can also increase growth and the secretion of bile, and can promote gallbladder contraction, and acts on fairly obvious.
13) Folium Mori, Folium Mori contain the functional materials such as 17 seed amino acids, multiple teleorganic trace element, vitamin and dietary fiber, are a kind of raw materials of natural, cheap and good-quality new type functional food.Contain inokosterone (inokosterone), ecdysterone (ecdysterone), β-Bao sterol, globulariacitrin, Mulberry glycoside (morocetin), Isoquercitrin, umbelliferone (umbelliferone), scopolin (scopolin), α-, β-hexenoic aldehyde (α-, β-hexenal), trigonelline (trigonelline), choline, adenine, aspartic acid, chlorogenic acid.Exploitation Novel antidiabetic Folium Mori contain the blood-sugar decreasing actives such as N-Me-DNJ, GAL-DNJ, fagomine, have significant hypoglycemic activity, and toxicity are little, take safety, have bright prospects as the Novel antidiabetic Application and Development.Folium Mori contain alkaloids, this compounds also is one of main active ingredient of Folium Mori, mainly comprises the Mulberry Aglycone, DNJ (the wild mycin of 1-deoxidation), GAL-DNJ, N-Me-DNJ etc., wherein the content of DNJ is about 0.11%, is the plant leaf of unique DNJ of containing of finding up to now.In the plant that contains DNJ of finding at present, the content of DNJ is the highest in the Mulberry.
As from the foregoing, ingredient Rhizomadioscoreae of the present invention, Semen Euryales, Radix Trichosanthis, Flos Sophorae, Rhizoma Polygonati, Stigma Maydis, Radix Ophiopogonis, Radix Asparagi, propolis, curcumin all are the medical materials that can directly eat, and taste is fine, can be treated as oven dry be milled to fine powder rear directly being added in of sieving and cook steamed bread in the flour, improve people's appetite, and has a stomach-nourishing function, and Folium Mori, Rhizoma Polygonati Odorati, the Rhizoma Anemarrhenae also can be milled to be placed on after fine powder sieves and do together steamed bread in the flour, perhaps be boiled into to be mixed in behind the decoction and cook steamed bread in the flour, the program of cooking steamed bread is the technology that prior art adopts.
Folium Mori in the medicine of the present invention contain unique alkaloid such as l one deoxynojirimycin (DNJ), GAL-DNJ, N-Me-DNJ etc., and can suppress blood glucose value and raise and cholesterol absorption, be the jinx of diabetes.Sitosterol, stigmasterol, triterpenoid compound, Y one aminobutyric acid (GABA) contained in the medicine of the present invention are the bases of the necessary cholesterol of synthesized human, can alleviate even eliminate hepatocellular degeneration and necrosis, promote hepatocellular regeneration, and have neurotransmitter and hypotensive effect.Radix Ophiopogonis polysaccharide all has obvious inhibitory action to the mice hyperglycemia due to glucose, alloxan and the epinephrine, and mechanism may be for reducing alloxan to the beta Cell of islet damage or improving the β cell function that damages.Polygonatum polysaccharide can reduce blood glucose in diabetic mice [12]; Reduce the HbAlc level; RAGEmRNA expresses in center downward regulating, the nephridial tissue.Polygonatum polysaccharide can raise plasma insulin and C peptide level can also suppress immunologic injury and the radical damage of pancreas due to the streptozotocin, thereby improve the secretory function of islets of langerhans.The curcumin of flavones ingredient can significantly reduce blood plasma and liver tg, T-CHOL and the low density lipoprotein, LDL that high lipid food adds the diabetic mice that streptozotocin induces, reduce model mice fasting glucose and glycolated hemoglobin, raising carbohydrate tolerance, obviously improve sugar, the lipid metabolism of diabetic mice, the steatosis of liver and aortic arch and Atherosclerosis pathological changes are obviously alleviated.The Rhizoma Anemarrhenae anti-diabetic activity composition of saponins is chimonin and chimonin-7-O-β-glucosides.And by the suitable nutrition product that adds a little medicine Rhizomadioscoreae etc., provide human body opposing function, accomplish the treating both the exterior and interior purpose.
Above-mentioned these natural drug effective active compositions comprise alkaloid, terpenoid, flavone, saponin, polysaccharide, steroidal, insulin, sulfide linkage chemical compound, unsaturated fatty acid etc.; The comprehensive coordination effect, blood pressure lowering, blood sugar lowering approach are various, act on many target spots, can effectively control the state of an illness, reduce and complication such as hypertension that diabetes-alleviating causes.
(2) medicine of the present invention is on the impact of hyperlipemia diabetic mice glycolipid metabolism
1.1 the preparation of drug agents of the present invention and pastille thing flour paste
Take by weighing in proportion the Chinese medicine formula dosage of Rhizomadioscoreae, Semen Euryales, Rhizoma Polygonati Odorati, the Rhizoma Anemarrhenae, Radix Trichosanthis, Flos Sophorae, Rhizoma Polygonati, Stigma Maydis, Radix Ophiopogonis, Radix Asparagi, propolis, curcumin and the Folium Mori of above-mentioned formula ratio, pouring above-mentioned Chinese medicine into medicinal cupping uses cold water soak after 15～30 minutes, changed the slow fire constantly boiling into 20～30 minutes after medicine elder generation intense fire is fried boiling, then medicine juice is leached, changed the slow fire constantly boiling into 20～30 minutes after medicinal residues add hot water again first intense fire is fried boiling in the same old way, and then medicine juice is leached; Twice medicine juice merged 50%～150% by weight percentage the medicine juice that is concentrated into original crude drug amount; Concentrating under reduced pressure is concentrated into ointment.1) the ointment water is mixed with the diluent of 0.8g (crude drug)/ml, and is for subsequent use.2) ointment water and flour are mixed with the flour paste liquid of 0.8g (crude drug)/ml;
1.2 preparation diabetes rat model
50 of rats weigh 195.5 ± 6.5g, and male and female are not limit, and after all rat adaptabilities fed for 1 week, are divided at random 5 groups: the A. Normal group, and B. diabetes model matched group, the medicine group of the present invention of D, E different dosing level, C is medicine flour paste liquid group.10 of every group of laboratory animals, single cage is raised, and freely drinks water and ingests.
1.3 observation hypoglycemic activity
Above-mentioned 5 groups of rats are gastric infusion respectively.A group: normal saline group: B group: diabetes model matched group; C, D, the E group:
The medicine ointment diluent of the present invention of various dose continues to feed, and the rat blood sugar situation of change respectively organized in record simultaneously, carries out carbohydrate tolerance test after 0 week, 4 weeks, 8 weeks.Overnight fasting is cut tail blood sampling, and the rapid blood sugar instrument is surveyed fasting glucose, and with the dosage gavage glucose solution of 2g/kg body weight, cuts the tail blood sampling in 30,60,120 minutes after the gavage to survey carbohydrate tolerance, calculates area under the glucose tolerance curve.
1.4 result
Result of the test shows (table 1), medicine ointment diluent of the present invention and medicine flour paste liquid are to the administration of diabetes model rat oral gavage, rat blood sugar reduces than Normal group after 8 weeks, C group rat fasting blood-glucose on average is down to 9.27mmol/l by the 16.93mmol/l before the administration, the average 7.66mmol/l that reduces, D group rat fasting blood-glucose on average is down to 5.73mmol/l by the 16.35mmol/l before the administration, the average 10.60mmol/l that reduces, E group rat fasting blood-glucose on average is down to 4.25mmol/l by the 16.72mmol/l before the administration, the average 12.47mmol/l that reduces is all extremely remarkable with model control group difference.
Table 1 drug extract diluent of the present invention and medicine flour paste liquid gastric infusion are on the impact of rat fasting blood-glucose
Above-mentioned 5 groups of rats are gastric infusion respectively.A group: normal saline: B group: diabetes model matched group; C, D, E group: begin gastric infusion after the grouping, once a day.Normal saline group, diabetes model matched group and C, D, the E group is given the excipient aqueous solution of equivalent every day.The normal saline group is with normal feedstuff, the diabetes model matched group is with high lipid food, all the other C, D, E respectively organize in grouping and begin to raise after the administration take high lipid food (by weight percentage prescription as: 10% Adeps Sus domestica, 2% cholesterol, 0.5% sodium cholate, 10% milk powder, 7.5% sucrose and 70% normal feedstuff powder).The experimental session animal freely drinks water, and quantitatively raises food by body weight.Monitoring body weight next day of mice.After 4 weeks of administration, survey blood glucose with glucose oxidase method, enzymic colorimetric is surveyed serum total cholesterol and serum triglycerides.
Table 24 weeks for the treatment of are on the impact of diabetic mice fasting glucose, carbohydrate tolerance and glycolated hemoglobin
After 4 weeks of administration, area and glycolated hemoglobin all are significantly higher than the normal saline group under diabetes model control group mice fasting glucose, the glucose tolerance curve, show that carbohydrate tolerance descends; With the diabetes model matched group relatively, C, D, E group mice fasting glucose all has decline, D wherein, the E group significantly reduces; C group mice glycolated hemoglobin descends to some extent; This is because the C group is medicine flour paste liquid group, flour is arranged here, thereby decrease speed can be slow, at this also provable flour that contains medicine, can reduce area and glycolated hemoglobin under fasting glucose, the glucose tolerance curve, it can be used as and alleviates, improves prevention and treatment type i diabetes, type ii diabetes or comprise hyperglycemia, impaired glucose tolerance, the complication that lipid metabolism is unusual and above-mentioned illness causes because of what diabetes caused.
(3) toxicity test of medicine of the present invention
Give 10 rat oral gavage drug agents of the present invention, dosage is equivalent to 50g/Kg, and the rat spontaneous activity reduces after the administration, recover normal behind 5～6h, Continuous Observation 10d, none death, this product avirulence is described, this is because the medical material that the present invention adopts all is edible.
(4) beneficial effect of the present invention: the present invention has proved that by zoopery said medicine can alleviate, improve prevention and treatment type i diabetes, type ii diabetes or comprise hyperglycemia, impaired glucose tolerance, the complication that lipid metabolism is unusual and above-mentioned illness causes because of what diabetes caused, can be used for preparing prevention or improve or medicine, the health product for the treatment of hyperglycemia, abnormal carbohydrate metabolism, diabetes or the various clinical complications that cause because of diabetes, and can be made as the steamed bread food consumption; Can significantly reduce blood plasma and liver tg, T-CHOL and low density lipoprotein, LDL that high lipid food adds the diabetic mice that streptozotocin induces, reduce model mice fasting glucose and glycolated hemoglobin, raising carbohydrate tolerance, obviously improve sugar, the lipid metabolism of diabetic mice, the steatosis of liver and aortic arch and Atherosclerosis pathological changes are obviously alleviated.And has preferably Expected Results.
The characteristics of medicine of the present invention:
(1) this preparation select the medicated diet homology plant tissue as raw material, utilize comprehensive function prevention, the treatment diabetes of the contained special effective ingredient of plant tissue and prescription, nontoxic to human body without chemical sweeting agent, suitable long-term taking.
(2) this preparation and flour are mixed and made into steamed bread, can easyly measure, arrange in pairs or groups abundant, mouthfeel is diversified; As staple food, nutritious without bitterness sense, instant is accomplished everyday diet, alleviates until treat and cure purpose everyday, meets the state food health law.
(3) the light disease person of this preparation can use separately.Can use with other antidiabetic drugs and insulin combination than serious symptom person, but can gradually reduce the use amount of antidiabetic drug and insulin, successful increases, and can significantly alleviate or eliminate other complication, increases immunity of organisms, improves the patient body situation.
(5) the medical effect statistical result of medicine of the present invention is as follows:
(1) diabetics 100 examples: male 20 examples wherein, women 80 examples; (2) hyperpietic's 20 examples: male 15 examples wherein, women 5 examples; (3) other patient's 5 examples: male 4 examples wherein, women 1 example.
Diabetes and complication patient adopt preparation or 1 course for the treatment of of tablet (30 days) of health medicine preparation of the present invention, every day 3 times, each 6 effect observation, the blurred vision effective percentage reaches 90%, the skin pruritus effective percentage reaches 80%, firmly just, the constipation effective percentage reaches 100%, the oral ulcer effective percentage reaches 90%, uncomfortable as gastrointestinal function, sleep state etc. almost effective percentage near 100%.
(5) model case
1) model case one: Wu XX, and the woman, 70 years old, certain worker of factory suffered from diabetes 17 years.(tablet that adopts the embodiment of the invention 1 prescription to make)
Main disease: 1. sleep is bad; 2. legs and feet edema, unable, the general fatigue of both legs; 3. the long-term taking Western medicine causes gastrointestinal upset; 4. blurred vision etc.
Began to take the tablet that the present invention makes in 2003, every day 3 times, each 4, onset in 7 days, 1 the course for the treatment of health improve comprehensively, health is salubrious, sleep is steady and sure, legs and feet edema sx↓ is walked energetically, gastrointestinal function takes a turn for the better, and is clearer depending on thing.
2) model case two: an XX, and the woman, 38 years old, unemployed, suffered from diabetes 7 years.Take 1 course for the treatment of of tablet that the present invention makes, every order 3 times, each 4, the intestines and stomach takes a turn for the better, and becomes clear depending on thing, and health is salubrious.(tablet that adopts the embodiment of the invention 1 prescription to make)
3) model case three: Lee XX, woman, 53 years old, certain worker of factory.Suffered from diabetes 21 years, insulin injection 17 years.The long-term pruritus of skin, ulcer all occurs every month in the oral cavity, needs three days ability of transfusion to take a turn for the better, and it is bad to sleep, and it is very dry to defecate, and hypoglycemia often occurs, puffiness of face, malaise.
On July 16th, 2008 began to come the here diagnosis and treatment, it is said that its culinary art is pretty good, mobilize her to carry out the food auxiliary treatment, we provide the flour by the medicament preparation of the embodiment of the invention 2, it is edible to allow it go home to make steamed bread, and eat every days 3, each 1-2 piece, 1 the course for the treatment of skin pruritus alleviate, oral ulcer is clearly better, and is edible after 2 months, according to informing that face eliminates edema gradually, whole body is no longer weak, rare hypoglycemia after 100 days just stops injection of insulin, does until now the medicated diet steamed bread everyday, or else use infusion treatment, health is obviously improved.Skin recovers normally do not have aphtha fully now, and stool is normal, can also go out amusement every afternoon.
The specific embodiment
The present invention further understands the present invention by specific embodiment given below, but following embodiment is not limitation of the present invention.
Embodiment one:
(1) takes by weighing in proportion the Chinese medicine formula dosage of Rhizomadioscoreae 7 gram, Semen Euryales 6 grams, Rhizoma Polygonati Odorati 5 grams, the Rhizoma Anemarrhenae 5 grams, Radix Trichosanthis 6 grams, Flos Sophorae 7 grams, Rhizoma Polygonati 7 grams, Stigma Maydis 6 grams, Radix Ophiopogonis 4 gram, Radix Asparagi 5 grams, propolis 5 grams, curcumin 4 grams and Folium Mori 6 grams of formula ratio, pouring above-mentioned Chinese medicine into medicinal cupping uses cold water soak after 20 minutes, changed the slow fire constantly boiling into 20 minutes after medicine elder generation intense fire is fried boiling, then medicine juice is leached, changed the slow fire constantly boiling into 25 minutes after medicinal residues add hot water again first intense fire is fried boiling in the same old way, and then medicine juice is leached; Twice medicine juice merged the medicine juice that is concentrated into 100 grams; Medicine juice can directly be drunk, or makes tablet by following 2-6 step.Also can be made into general preparation on the materia medicas such as capsule;
(2) above-mentioned medicine juice decompression (decompression is to 0.1MPa pressure) is condensed into extractum; Pour extractum into evaporating dish, heat 70 ℃ and continuous the stirring 2 hours, make into the thick paste shape;
(3) add 100 gram calcium sulfate, 20 gram pharmagels, continue 80 ℃ of heating and stirred 2 hours, make mixture become thick paste;
(4) thick paste in the step (3) is spread out in stainless steel disc, put in the baking oven in 80 ℃ of dryings 24 hours, get dry extract;
(5) dried cream powder in the step (4) is broken into fine powder;
(6) with the fine powder mix homogeneously of step (5), add again 80 gram calcium sulfate and be mixed, granulation after 70 ℃ of lower dried, adds the magnesium of 5 grams, becomes the tablet of conventional specification with the tablet machine tabletting.
Above-mentioned calcium sulfate, magnesium stearate and gelatin all are medicinal.
Embodiment two:
(1) Rhizomadioscoreae 70 gram, Semen Euryales 60 grams, Radix Trichosanthis 60 grams, Flos Sophorae 70 grams, Rhizoma Polygonati 70 grams, Stigma Maydis 60 grams, Radix Ophiopogonis 40 gram, Radix Asparagi 50 grams, propolis 50 grams and curcumin 40 grams that take by weighing in proportion formula ratio mix, dry, grind to form 570 grams, cross 100 mesh sieves obtains thin medicated powder 500 grams stand-by (cross 100 mesh sieves, sieve remove slag remaining); Pouring Rhizoma Polygonati Odorati 50 grams, the Rhizoma Anemarrhenae 50 grams, Folium Mori 60 grams into medicinal cupping uses cold water soak after 20 minutes, changed the slow fire constantly boiling into 20 minutes after medicine elder generation intense fire is fried boiling, then medicine juice is leached, changed the slow fire constantly boiling into 25 minutes after medicinal residues add hot water again first intense fire is fried boiling in the same old way, and then medicine juice is leached; Twice medicine juice merged the medicine juice that is concentrated into 100 grams; (2) the thin medicated powder of above-mentioned 500 grams, the medicine juice of 100 grams and the flour of 7000 grams are added the water mix homogeneously, add fresh yeast 10 grams, until with become dough, knead in the rearmounted basin, the raggle block cloth that wets is placed on warm place 2 hours, and question handler is swollen can make steamed bread when being dealt into 2 times of original volume, and steaming and decocting becomes edible steamed bread, is the medicated diet steamed bread.
Embodiment three:
(1) takes by weighing in proportion Rhizomadioscoreae 70 gram, Semen Euryales 60 grams, Radix Trichosanthis 60 grams, Flos Sophorae 70 grams, Rhizoma Polygonati 70 grams, Stigma Maydis 60 grams, Radix Ophiopogonis 40 gram, Radix Asparagi 50 grams, propolis 50 grams, curcumin 40 grams, Rhizoma Polygonati Odorati 50 grams, the Rhizoma Anemarrhenae 50 grams, Folium Mori 60 grams of formula ratio and mixes, dry, grind to form 730 grams, cross 100 mesh sieves and obtain thin medicated powder 700 grams stand-by (remove slag then be left); (2) flour with the thin medicated powder of 700 grams and 7500 grams add the water mix homogeneously, add fresh yeast 15 and restrain, and become dough, knead in the rearmounted basin, the raggle block cloth that wets is placed on warm place 2 hours, question handler is swollen can make steamed bread when being dealt into 2 times of original volume, and steaming and decocting becomes edible steamed bread, is the medicated diet steamed bread.
Claims (5)
1. medicine for the treatment of diabetes, it is to be made by the raw material of following weight proportioning:
10～6 parts of Rhizomadioscoreae, 10～5 parts of Semen Euryaless, 10～3 parts of Rhizoma Polygonati Odorati, 8～3 parts of the Rhizoma Anemarrhenaes, 8～3 parts of Radix Trichosanthis, 8～3 parts in Flos Sophorae, 8～2 parts of Rhizoma Polygonatis, 8～2 parts of Stigma Maydis, 6～2 parts of Radix Ophiopogonis, 6～2 parts of Radix Asparagis, 6～2 parts of propolis, 6～1 parts of curcumins, 6～1 parts on Folium Mori.
2. medicinal steamed bread for treating diabetes for the treatment of diabetes, per 100 grams contain the medicine of being made by Rhizomadioscoreae, Semen Euryales, Rhizoma Polygonati Odorati, the Rhizoma Anemarrhenae, Radix Trichosanthis, Flos Sophorae, Rhizoma Polygonati, Stigma Maydis, Radix Ophiopogonis, Radix Asparagi, propolis, curcumin and Folium Mori of 3-10% percentage by weight in the steamed breads, and the weight proportion of described medicine is as follows:
10～6 parts of Rhizomadioscoreae, 10～5 parts of Semen Euryaless, 10～3 parts of Rhizoma Polygonati Odorati, 8～3 parts of the Rhizoma Anemarrhenaes, 8～3 parts of Radix Trichosanthis, 8～3 parts in Flos Sophorae, 8～2 parts of Rhizoma Polygonatis, 8～2 parts of Stigma Maydis, 6～2 parts of Radix Ophiopogonis, 6～2 parts of Radix Asparagis, 6～2 parts of propolis, 6～1 parts of curcumins, 6～1 parts on Folium Mori.
3. preparation method for the treatment of the medicine of diabetes, comprise the steps: that (1) takes by weighing Rhizomadioscoreae 7 grams of formula ratio in proportion, Semen Euryales 6 grams, Rhizoma Polygonati Odorati 5 grams, the Rhizoma Anemarrhenae 5 grams, Radix Trichosanthis 6 grams, Flos Sophorae 7 grams, Rhizoma Polygonati 7 grams, Stigma Maydis 6 grams, restrain Radix Ophiopogonis 4, Radix Asparagi 5 grams, propolis 5 grams, the Chinese medicine formula dosage of curcumin 4 grams and Folium Mori 6 grams, pouring above-mentioned Chinese medicine into medicinal cupping uses cold water soak after 20 minutes, changed the slow fire constantly boiling into 20 minutes after medicine elder generation intense fire is fried boiling, then medicine juice is leached, changed the slow fire constantly boiling into 25 minutes after medicinal residues add hot water again first intense fire is fried boiling in the same old way, and then medicine juice is leached; Twice medicine juice merged the medicine juice that is concentrated into 100 grams;
(2) above-mentioned medicine juice concentrating under reduced pressure is become extractum; Pour extractum into evaporating dish, heat 70 ℃ and continuous the stirring 2 hours, make into the thick paste shape;
(3) add 100 gram calcium sulfate, 20 gram pharmagels, continue 80 ℃ of heating and stirred 2 hours, make mixture become thick paste;
(4) thick paste in the step (3) is spread out in stainless steel disc, put in the baking oven in 80 ℃ of dryings 24 hours, get dry extract;
(5) dried cream powder in the step (4) is broken into fine powder;
(6) with the fine powder mix homogeneously of step (5), add again 80 gram calcium sulfate and be mixed, granulation after 70 ℃ of lower dried, adds the magnesium of 5 grams, becomes tablet with the tablet machine tabletting.
4. preparation method for the treatment of the medicinal steamed bread for treating diabetes of diabetes comprises the steps: that (1) takes by weighing in proportion Rhizomadioscoreae 70 grams of formula ratio, Semen Euryales 60 grams, Radix Trichosanthis 60 grams, Flos Sophorae 70 grams, Rhizoma Polygonati 70 grams, Stigma Maydis 60 grams, Radix Ophiopogonis 40 gram, Radix Asparagi 50 grams, propolis 50 grams and curcumin 40 grams and mixes, dries, grinds to form 570 grams, crosses 100 mesh sieves and obtain thin medicated powder 500 and restrain; Pouring Rhizoma Polygonati Odorati 50 grams, the Rhizoma Anemarrhenae 50 grams, Folium Mori 60 grams into medicinal cupping uses cold water soak after 20 minutes, changed the slow fire constantly boiling into 20 minutes after medicine elder generation intense fire is fried boiling, then medicine juice is leached, changed the slow fire constantly boiling into 25 minutes after medicinal residues add hot water again first intense fire is fried boiling in the same old way, and then medicine juice is leached; Twice medicine juice merged the medicine juice that is concentrated into 100 grams; (2) the thin medicated powder of above-mentioned 500 grams, the medicine juice of 100 grams and the flour of 7000 grams are added the water mix homogeneously, add fresh yeast 10 grams, with become dough, knead in the rearmounted basin, the raggle block cloth that wets is placed on warm place 2 hours, and question handler is swollen can make steamed bread when being dealt into 2 times of original volume, and steaming and decocting becomes edible steamed bread, is the medicated diet steamed bread.
5. preparation method for the treatment of the medicinal steamed bread for treating diabetes of diabetes comprises the steps: that (1) takes by weighing in proportion Rhizomadioscoreae 70 grams of formula ratio, Semen Euryales 60 grams, Radix Trichosanthis 60 grams, Flos Sophorae 70 grams, Rhizoma Polygonati 70 grams, Stigma Maydis 60 grams, Radix Ophiopogonis 40 gram, Radix Asparagi 50 grams, propolis 50 grams, curcumin 40 grams, Rhizoma Polygonati Odorati 50 grams, the Rhizoma Anemarrhenae 50 grams, Folium Mori 60 grams and mixes, dries, grinds to form 730 grams, crosses 100 mesh sieves and obtain thin medicated powder 700 and restrain; (2) flour with the above-mentioned 700 thin medicated powder of gram and 7500 grams adds the water mix homogeneously, add fresh yeast 15 grams, with become dough, knead in the rearmounted basin, the raggle block cloth that wets is placed on warm place 2 hours, and question handler is swollen can make steamed bread when being dealt into 2 times of original volume, and steaming and decocting becomes edible steamed bread, is the medicated diet steamed bread.
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| CN103431405B (en) * | 2013-07-19 | 2016-01-27 | 宫中林 | A kind of cactus steamed bun and preparation method thereof |
| CN103494074A (en) * | 2013-08-27 | 2014-01-08 | 郭腾霖 | Purple sweet potato-flavor stomach-strengthening steamed bread and preparation method thereof |
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| CN112385841A (en) * | 2020-07-28 | 2021-02-23 | 深圳市老年医学研究所 | Medicated diet composition for type 2 diabetes and preparation method thereof |
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