CN101480473A - Compound recipe for reducing blood sugar as well as preparation method and application - Google Patents
Compound recipe for reducing blood sugar as well as preparation method and application Download PDFInfo
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- CN101480473A CN101480473A CNA2008100193738A CN200810019373A CN101480473A CN 101480473 A CN101480473 A CN 101480473A CN A2008100193738 A CNA2008100193738 A CN A2008100193738A CN 200810019373 A CN200810019373 A CN 200810019373A CN 101480473 A CN101480473 A CN 101480473A
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Abstract
The invention provides a compound for decreasing blood glucose, which is prepared by using polygonatum, corn silk, mulberry leaves, Tuckahoe, Chinese yams and lotus leaves used as raw material. The invention also provides a preparation method for the compound and the application of preparing food, food additive, health-care food and medicaments for preventing and treating diabetes and complications. The compound has the functions for supplementing qi, nourishing yin, promoting the production of body fluid to quench thirst, moistening lung, strengthening the spleen and tonifying liver and kidney, can decrease blood glucose, keep normal weight, relieve the burden of islet B cells, regulate endocrine, enhance immune and has auxiliary efficacy in the processes of preventing and treating diabetes and complications and the like.
Description
Technical field:
The invention belongs to food, health food, pharmaceutical research field, relating to a kind of is the compound recipe and preparation method thereof of primary raw material with the natural Chinese medicines, and has application in the food, food additive, health food, medicine of blood sugar lowering effect in preparation.
Background technology:
Diabetes are a kind of carbohydrate metabolism disturbances with genetic predisposition, and with neural and blood vessel retrograde affection, are feature unusually with hyperglycemia, glycosuria, glucose tolerance attenuating and insulin release test.Be divided into type 1 diabetes, immune-mediated diabetes, the special property sent out diabetes, the diabetes of type 2 diabetes mellitus and other specific types.Type 1 diabetes is that B cell is impaired, and long-term type 2 diabetes mellitus also often makes islet function descend.From theory of Chinese medical science, diabetes show as deficiency of both QI and YIN, phlegm-turbidity and blood stasis blood, venation block.
At present, China's onset diabetes number is lasting ascendant trend, for the type 2 diabetes mellitus patient, improves generation, development that glycemic control can obviously be improved complication, but it is few to reach the crowd of desirable controlled target.The complication of diabetes is that diabetics causes death, major cause of morbidity, especially cardiovascular and cerebrovascular complication have become the topmost cause of death of diabetes (up to 75%).The diabetic complication investigation that domestic one 4000 people participates in shows: merge the lower limb nerve affection person and account for 38%, cataract accounts for 44%, Microalbuminuria accounts for 33%, and severe complication (mainly referring to myocardial infarction, cerebrovascular accident, renal failure, blind and amputation) is 2%～7%.Along with the progress of diabetic duration, the incidence rate of various chronic complicating diseases also progressively increases.The expert advocates and surmounts the blood glucose center mode at present, reduces insulin resistant and blood sugar lowering and develops simultaneously, and the control of blood glucose, blood pressure, blood fat is laid equal stress on.
Hyperglycemia state is the main cause that causes onset diabetes and complication thereof.Hyperglycemia state can produce a large amount of free radicals in vivo, and makes the interior free yl defense mechanism impaired, and both cause oxidative stress to increase the weight of jointly, cause histiocytic peroxide injury.Islets of langerhans is one of sensitive organization of peroxide injury, and islet tissue cellularity, dysfunction, especially B cell function deficiency can cause diabetes and produce.The morbidity of diabetes and the damage of free radical have substantial connection.These viewpoint prompting people adopt the probability of antioxidant therapy diabetes.
Summary of the invention:
Technical problem to be solved by this invention is that a kind of compound recipe with blood sugar lowering effect will be provided, compound recipe that this compound recipe is made up of Rhizoma Polygonati Odorati, Stigma Maydis, Folium Mori, Poria, Rhizoma Dioscoreae, Folium Nelumbinis and preparation method thereof also provides the application of this compound recipe in preparation food, food additive, health food, medicine.
The present invention is by said components is made up according to certain consumption, through pulverizing or the solvent extraction, concentrate a series of modern extraction process flow processs such as drying, extract effective component wherein, the application that is used for preparing food, food additive, health food and medicine.
The amount ranges of the used medical material of extract provided by the present invention is designated as (1000 preparation unit) with weight: Rhizoma Polygonati Odorati 10～100g, Stigma Maydis 200～400g, Folium Mori 100～800g, Poria 1～80g, Rhizoma Dioscoreae 1～80g, Folium Nelumbinis 10～200g; Preferable amount is (1000 preparation unit) Rhizoma Polygonati Odorati 60～90g, Stigma Maydis 200～300g, Folium Mori 300～500g, Poria 10～30g, Rhizoma Dioscoreae 10～30g, Folium Nelumbinis 100～150g.
Effective spice provided by the present invention is to be prepared from by following method: Poria, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Folium Nelumbinis powder are broken into fine powder.Stigma Maydis is cleaned, and is cut into several sections, puts into gauze bag, and tying and Folium Mori together decoct with water, 3h for the first time, 2h for the second time, collecting decoction leaves standstill 12h, supernatant is evaporated to the clear paste of relative density 1.36～1.38, and with above-mentioned powder mixes drying, powder becomes fine powder, mixing promptly.
This product is rich in polysaccharides of Folium Mori, pachyman, fragrant solomonseal rhizome polyoses, corn silk polysaccharide and total saponins, Chinese yam polysaccharide, lotus leaf alkaloid and flavonoid and various trace elements, tens kinds of pure natural substance with very strong pharmacologically active such as vitamin.Have supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, the effect of lung moistening spleen invigorating, the liver and the kidney tonifying, energy blood sugar lowering, keep normal type, alleviate the burden of B cell, endocrine regulation, enhance immunity can play auxiliary effect in processes such as prevention and treatment diabetes and complication thereof.
Below further explain the present invention with embodiment, but the present invention is not limited to this.
Specific embodiment:
Embodiment 1: prescription is formed (1000 preparation unit):
Rhizoma Polygonati Odorati 80g Stigma Maydis 280g
Folium Mori 420g Poria 15g
Rhizoma Dioscoreae 15g Folium Nelumbinis 140g
Embodiment 2, preparation method:
Poria, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Folium Nelumbinis powder are broken into fine powder.Stigma Maydis is cleaned, and is cut into several sections, puts into gauze bag, and tying and Folium Mori together decoct with water, 3h for the first time, 2h for the second time, collecting decoction leaves standstill 12h, supernatant is evaporated to the clear paste of relative density 1.36～1.38, and with above-mentioned powder mixes drying, powder becomes fine powder, mixing promptly.
Embodiment 3, tablet
Poria, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Folium Nelumbinis powder are broken into fine powder.Stigma Maydis is cleaned, and is cut into several sections, puts into gauze bag, tying and Folium Mori together decoct with water, for the first time 3h, 2h for the second time, collecting decoction, leave standstill 12h, supernatant is evaporated to the clear paste of relative density 1.36～1.38, and with above-mentioned powder mixes drying, powder becomes fine powder, mixing according to the tablet conventional method, adds the tablet that edible adjuvant is prepared into different size.
Embodiment 4, capsule
Poria, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Folium Nelumbinis powder are broken into fine powder.Stigma Maydis is cleaned, and is cut into several sections, puts into gauze bag, tying and Folium Mori together decoct with water, for the first time 3h, 2h for the second time, collecting decoction leaves standstill 12h, and supernatant is evaporated to the clear paste of relative density 1.36～1.38, and with above-mentioned powder mixes drying, powder becomes fine powder, and mixing adds edible adjuvant, granulate, be prepared into the capsule of different size according to the capsule conventional method.
Effective spice provided by the present invention is except can being prepared into above-mentioned several preparation, conventional formulation forms such as granule, soft capsule, pill, oral liquid, injection can also be prepared into as required, also special preparations such as slow releasing agent, controlled release agent, dispersant, effervescent can be prepared into.
Below further explain the present invention by functional experiment.
One, to the therapeutical effect of alloxan induced hyperglycemia mice:
Experimental technique:
Get male mice in kunming, tail vein injection alloxan 60mg/kg, 72 hours posterior orbits are got blood and are surveyed blood glucose, the mice of getting the modeling success is divided into 4 groups (this product I group, this product II group, normal saline group, phenformin groups) at random, the administration for three days on end of administration group, matched group give normal saline, 3 hours eye sockets of fasting are got blood and are surveyed blood glucose after the last administration, carry out the t check with contrast between self cross-reference and group.Experimental result is represented with x ± sd.
Experimental result:
This product can significantly reduce the level of alloxan mouse model blood glucose.(annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01)
Table 1:
Two, to the preventive effect of alloxan induced hyperglycemia mice:
Experimental technique:
Get 50 of male Kunming kind white mice, be divided into 4 groups (this product I group, this product II group, normal saline group, gliclazide groups) at random, 10 every group, administration group prevention gastric infusion is 3 days before the experiment, and matched group is given normal saline.After the last administration 2 hours, tail vein injection alloxan 60mg/kg got blood and surveys blood glucose after 72 hours.Contrast between the work group.Experimental result is represented with x ± sd.
Experimental result:
This product prevention administration can prevent the generation of alloxan induced mice hyperglycemia.(annotate: compare with the normal saline group
*P＜0.01)
Table 2:
Claims (8)
1, a kind of compound recipe of blood sugar lowering is characterized in that being made up of Rhizoma Polygonati Odorati, Stigma Maydis, Folium Mori, Poria, Rhizoma Dioscoreae, Folium Nelumbinis.
2, compound recipe according to claim 1 is characterized in that each component amount ranges (1000 preparation unit) is designated as with weight: Rhizoma Polygonati Odorati 10～100g, Stigma Maydis 200～400g, Folium Mori 100～800g, Poria 1～80g, Rhizoma Dioscoreae 1～80g, Folium Nelumbinis 10～200g.
3, compound recipe according to claim 2 is characterized in that each component preferable amount (1000 preparation unit) is designated as with weight: Rhizoma Polygonati Odorati 60～90g, Stigma Maydis 200～300g, Folium Mori 300～500g, Poria 10～30g, Rhizoma Dioscoreae 10～30g, Folium Nelumbinis 100～150g.
4, a kind of preparation method that contains any described compound recipe of claim 1-3, it is characterized in that: Poria, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Folium Nelumbinis powder are broken into fine powder.Stigma Maydis is cleaned, and is cut into several sections, puts into gauze bag, and tying and Folium Mori together decoct with water, 3h for the first time, 2h for the second time, collecting decoction leaves standstill 12h, supernatant is evaporated to the clear paste of relative density 1.36～1.38, and with above-mentioned powder mixes drying, powder becomes fine powder, mixing promptly.
5, a kind ofly contain the application that the described compound recipe of claim 1 is used for preparing food, food additive, health food, medicine.
6, the application of compound recipe according to claim 5 is characterized in that can be used for preparing the application in food with blood sugar lowering effect, food additive, health food, the medicine.
7, a kind of described compound recipe of claim 1 that contains can add proper auxiliary materials and is prepared into any dosage form of acceptable on the pharmaceutics.
8, the dosage form of compound recipe according to claim 7 is characterized in that it can being all acceptable preparations such as tablet, hard capsule, granule, soft capsule, pill, oral liquid, buccal tablet, drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100193738A CN101480473A (en) | 2008-01-07 | 2008-01-07 | Compound recipe for reducing blood sugar as well as preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100193738A CN101480473A (en) | 2008-01-07 | 2008-01-07 | Compound recipe for reducing blood sugar as well as preparation method and application |
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| CN101480473A true CN101480473A (en) | 2009-07-15 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380051A (en) * | 2010-09-06 | 2012-03-21 | 柯依坤 | Medicinal steamed bread for treating diabetes |
| CN102512591A (en) * | 2011-12-16 | 2012-06-27 | 五寨县金达实业有限责任公司 | Composition with functions of losing weight and reducing blood glucose and lipid |
| CN103599422A (en) * | 2013-12-03 | 2014-02-26 | 蚌埠市宫氏太极医疗用品科技有限公司 | Mulberry lotus polygonatum-odoratum tea and preparation method thereof |
| CN104904949A (en) * | 2015-06-25 | 2015-09-16 | 西安交通大学 | Blood-glucose-reducing Mulgedium tataricum tea and preparation method thereof |
| CN105054079A (en) * | 2015-07-15 | 2015-11-18 | 西南大学 | Processing and utilizing method of sweet potatoes |
| CN105639637A (en) * | 2016-02-01 | 2016-06-08 | 林爱玉 | Health care food with blood sugar reduction function |
| CN108524766A (en) * | 2018-04-11 | 2018-09-14 | 天津国际生物医药联合研究院 | A kind of Chinese medicine composition and its application |
| CN112274610A (en) * | 2020-12-14 | 2021-01-29 | 姚忠泽 | A Chinese medicinal granule with medicinal and edible effects for lowering blood sugar, and its preparation method |
-
2008
- 2008-01-07 CN CNA2008100193738A patent/CN101480473A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380051B (en) * | 2010-09-06 | 2013-10-30 | 柯依坤 | Medicinal steamed bread for treating diabetes |
| CN102380051A (en) * | 2010-09-06 | 2012-03-21 | 柯依坤 | Medicinal steamed bread for treating diabetes |
| CN102512591A (en) * | 2011-12-16 | 2012-06-27 | 五寨县金达实业有限责任公司 | Composition with functions of losing weight and reducing blood glucose and lipid |
| CN102512591B (en) * | 2011-12-16 | 2013-10-30 | 五寨县金达实业有限责任公司 | Composition with functions of losing weight and reducing blood glucose and lipid |
| CN103599422A (en) * | 2013-12-03 | 2014-02-26 | 蚌埠市宫氏太极医疗用品科技有限公司 | Mulberry lotus polygonatum-odoratum tea and preparation method thereof |
| CN103599422B (en) * | 2013-12-03 | 2016-01-13 | 蚌埠市宫氏太极医疗用品科技有限公司 | A kind of Sang He fragrant solomonseal rhizome tea and preparation method thereof |
| CN104904949B (en) * | 2015-06-25 | 2018-08-10 | 西安交通大学 | A kind of breast lettuce blood-sugar reducing tea and preparation method thereof |
| CN104904949A (en) * | 2015-06-25 | 2015-09-16 | 西安交通大学 | Blood-glucose-reducing Mulgedium tataricum tea and preparation method thereof |
| CN105054079A (en) * | 2015-07-15 | 2015-11-18 | 西南大学 | Processing and utilizing method of sweet potatoes |
| CN105054079B (en) * | 2015-07-15 | 2017-05-03 | 西南大学 | Processing and utilizing method of sweet potatoes |
| CN105639637A (en) * | 2016-02-01 | 2016-06-08 | 林爱玉 | Health care food with blood sugar reduction function |
| CN108524766A (en) * | 2018-04-11 | 2018-09-14 | 天津国际生物医药联合研究院 | A kind of Chinese medicine composition and its application |
| CN112274610A (en) * | 2020-12-14 | 2021-01-29 | 姚忠泽 | A Chinese medicinal granule with medicinal and edible effects for lowering blood sugar, and its preparation method |
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Open date: 20090715 |