CN107080250A - A kind of composition of auxiliary hyperglycemic, beverage and preparation method thereof - Google Patents
A kind of composition of auxiliary hyperglycemic, beverage and preparation method thereof Download PDFInfo
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- CN107080250A CN107080250A CN201710201484.XA CN201710201484A CN107080250A CN 107080250 A CN107080250 A CN 107080250A CN 201710201484 A CN201710201484 A CN 201710201484A CN 107080250 A CN107080250 A CN 107080250A
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- beverage
- auxiliary hyperglycemic
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The present invention relates to a kind of composition of energy auxiliary hyperglycemic, and the method that said composition is prepared into liquid oral beverage, solid particle beverage or effervescent tablet.Each raw material is as follows in parts by weight in said composition：5 ~ 10 parts of 20 ~ 50 parts of mulberry leaf, 10 ~ 20 parts of eucommia Bark male flower, 10 ~ 20 parts of Qingqian Willow leaf, 5 ~ 10 parts of corn stigma, 5 ~ 10 parts of the Radix Astragali, 5 ~ 10 parts of CHAGA and dendrobium candidum.Each raw material is weighed, is boiled with decocting and obtains extract solution for 2 times, L arabinose flavor adjustments are added, it is filtering, sterilizing, filling, produce liquid beverage；Said extracted liquid is concentrated, appropriate maltodextrin, L arabinoses is added, it is spray-dried to obtain solid particle beverage；The solid particle is divided into 2 parts, acid grain is made in a copy of it, and alkaline grain is made in another, acid grain and alkaline grain then are respectively dried into addition Macrogol 6000 mixes, and being sterilized after tabletting is made effervescent tablet.The present invention has significant auxiliary hyperglycemic effect, is suitable for more than 20 years old diabetes patient for oral use.
Description
Technical field
Liquid beverage, solid are prepared the present invention relates to a kind of composition of auxiliary hyperglycemic, and using said composition
Grain beverage, the preparation method of effervescence tablet beverage, belong to medicine and field of health care food.
Background technology
Health is most important something in life, and the body with a secondary health can just deserve to be called life good fortune
Good fortune, happy premise.Functional disturbance or forfeiture insulin secretion work(of the diabetes mainly due to human pancreas' excreting insulin
Caused by causing pathoglycemia.The diabetes data of the World Health Organization is shown：At least there has been people more than 1.8 hundred million in the current whole world
With diabetes, this numeral to the year two thousand thirty will rise to 3.6 hundred million.2005, nearly there are 1,100,000 people to die from diabetes.
Because the continuous improvement of living standard, the change of dietary structure, more and more nervous rhythm of life and dynamic many less
The factors such as the life style of seat, global diabetes morbidity increases very fast, and diabetes are had become after tumour, the heart
The chronic disease of the third-largest serious threat human health after vascular lesion.Whole world diabetic has exceeded 1.2 at present
Hundred million people, China patients occupy the second in the world, and the diabetes morbidity of China has been up to glycosuria in 9.6%, future 50 years at present
Disease will be a Chinese serious public health problem.The diabetes present situation of China is very severe interior in terms of survey data,
China has turned into the fastest-rising area of global range diabetes and as the big country of world's diabetes first at present.
At present, preventing and treating of the medical field to diabetes is main based on Western medicine, and these medicines need long-term or even taken all the life,
Not only spend big, and have certain side effect.It is early prevention, early intervention preferably to prevent and treat diabetes means, naturally to plant
It is so safe and effective and almost have no side effect based on the synthetic prescription of thing, and with it with good habits and customs.In the market has
The health protection tea of some auxiliary hyperglycemics, health food, but kind is relatively single, and formula action effect is limited, therefore, and exploitation is a kind of
Health food or the extract oral agent of blood glucose can be substantially reduced, is very necessary.
The content of the invention
Hypoglycemic liquid is prepared it is an object of the invention to provide a kind of composition of auxiliary hyperglycemic, and using said composition
The method of body beverage, solid particle beverage and effervescent tablet.
To achieve the above object, the technical solution adopted by the present invention is：A kind of composition of auxiliary hyperglycemic, by following heavy
Measure the raw material composition of part, 20 ~ 50 parts of mulberry leaf, 10 ~ 20 parts of eucommia Bark male flower, 10 ~ 20 parts of Qingqian Willow leaf, corn stigma 5 ~ 10
5 ~ 10 parts of part, 5 ~ 10 parts of the Radix Astragali, 5 ~ 10 parts of CHAGA and dendrobium candidum.
A kind of composition of auxiliary hyperglycemic as described above, is made up of the raw material of following parts by weight：30 parts of mulberry leaf, the bark of eucommia
6 parts of 15 parts of male flower, 15 parts of Qingqian Willow leaf, 6 parts of corn stigma, 8 parts of the Radix Astragali, 6 parts of CHAGA and dendrobium candidum.
A kind of beverage of auxiliary hyperglycemic as described above, including by a kind of composition of auxiliary hyperglycemic recited above
Middle mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum and appropriate food additives are mixed
Liquid beverage or solid particle or effervescence tablet beverage.
A kind of preparation method of auxiliary hyperglycemic liquid beverage, comprises the following steps：
Step（1）, weighed respectively respectively according to the weight ratio of each raw material in a kind of auxiliary hyperglycemic composition as described above
Raw material；
Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 50 ~ 200 times of water of the mixture material total weight parts, extraction 2 times is decocted under 100 °C, every time
Decoct and extract 15 ~ 90 minutes, obtain filtrate, aqueous extract A is made through filtering in merging filtrate；
Step（3）, to step（2）Appropriate L-arabinose is added in gained aqueous extract A, is well mixed, sterilized, packing is
Obtain liquid beverage.
A kind of preparation method of auxiliary hyperglycemic solid particle beverage, comprises the following steps：
Step（1）, the weight ratio of each raw material is weighed respectively respectively in a kind of auxiliary hyperglycemic composition as described above
Raw material；Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 10 ~ 50 times of water of the mixture material total weight parts, decocts and extracts 2 times under 100 °C, decocts every time
Boil extraction 30 ~ 120 minutes, obtain filtrate, aqueous extract B is made through filtering in merging filtrate；
Step（3）, by step（2）The aqueous extract B of gained, through being concentrated under reduced pressure, be concentrated into concentrate relative density for 1.20 ~
1.30, concentrate is obtained, appropriate maltodextrin is then added and L-arabinose is well mixed, be spray-dried, sterilize, divide
Dress obtains solid particle beverage.
A kind of preparation method of auxiliary hyperglycemic effervescent tablet, comprises the following steps：
Step（1）, weighed respectively respectively according to the weight ratio of each raw material in a kind of auxiliary hyperglycemic composition as described above
Raw material；
Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 10 ~ 50 times of water of the mixture material total weight parts, decocts and extracts 2 times under 100 °C, decocts every time
Boil extraction 30 ~ 120 minutes, obtain filtrate, aqueous extract C is made through filtering in merging filtrate；
Step（3）, by step（2）The aqueous extract C of gained, through being concentrated under reduced pressure, be concentrated into concentrate relative density for 1.20 ~
1.30, concentrate is obtained, appropriate maltodextrin is then added and L-arabinose is well mixed, be spray-dried, consolidate
Body particle A；
Step（4）, the step of taking 2 parts of identical weights（3）Gained solid particle A, a copy of it adds citric acid and mixed, and sprays quality
Concentration is 10% polyvinylpyrrolidone（PVP）Acid grain is made in ethanol solution, and another adds sodium acid carbonate and mixed, and sprays quality
Concentration is 10% polyvinylpyrrolidone（PVP）Alkaline grain is made in ethanol solution；
Step（5）, respectively by step（4）The acid grain of gained and alkaline grain are dried under 60 °C, are then stirred them and are mixed
Uniformly, add appropriate Macrogol 6000 to stir and evenly mix, through tabletting, sterilizing, thus obtaining the product effervescent tablet.
As described above, present invention employs mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, iron sheet stone
Dry measure used in former times etc. is raw material, and wherein mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma is new raw-food material, and the Radix Astragali and dendrobium candidum are health cares
Chinese medicine material.Containing a variety of hypoglycemic compositions such as polysaccharide, alkaloid, flavones, triterpene compound, with a variety of hypoglycemic effects
Mechanism, composition of the invention has good blood sugar decreasing effect.
Mulberry leaf, it is preferable with the mulberry leaf effect after the Frost's Descent.It is potent sugar containing alkaloids such as DNJs in mulberry leaf
Metabolic enzyme inhibitor, can effectively improve insulin resistance, with significant effect of lowering blood sugar.Mulberry leaf are approved as new food by China
Product raw material.
Eucommia Bark male flower is approved as in new raw-food material, eucommia Bark male flower containing chlorogenic acid, Quercetin isoreactivity by the Ministry of Public Health
Composition.Research finds that chlorogenic acid can effectively suppress the activity of 6- phosphoric acid grape enzyme in liver cell and reduce the decomposition generation of liver glycogen
Thank, so as to reduce blood sugar concentration, a kind of diabetes remedy of non-dependence insulin is provided for people.And in eucommia Bark male flower
The reduction hypoglycemic effect of Quercetin is also very good, to the inhibiting rate of alpha-glucosidase up to 57%.Eucommia Bark male flower has significant
Reduce hypoglycemic effect.
Qingqian Willow leaf tea have promote the production of body fluid to quench thirst, clearing away heat and removing summer-heat, decompression cardiac stimulant and the effect promoted longevity, be effectively used for
The diseases such as diabetes, hypertension, coronary heart disease, neurasthenia are prevented and treated, someone among the people is referred to as " hypoglycemic god tea ".It contains abundant
Natural medicinal component, such as polysaccharide, flavones, saponin(e chemical composition and some the essential trace elements of the human bodys, wherein polysaccharide into
Part has substantially reduction hypoglycemic effect, particularly has obvious curative effects to type II diabetes, therefore be increasingly subject to people's attention.Blue or green money willow
Leaf is approved as new raw-food material by China.
Corn stigma contains polysaccharide, flavones and saponins active ingredient, and someone is studied with corn silk water extract to alloxan
The diabetic mice of induction is treated, and the blood glucose and glycosylated hemoglobin of diabetic mice are significantly reduced, amount of insulin secretion
Significantly rise, can reduce blood glucose value by improving insulin level and repairing impaired beta cell.
Radix Astragali hypoglycemic effect is not by increasing the secretion or release of insulin, but by increasing tissue to glucose
Uptake and utilization mediate.The Radix Astragali can be by increasing glycogen synthase activity, IRS activity, protein kinase
B and protein kinase C activity, make the glucose transporter level increase of Skeletal Muscle Cell cardiac muscular tissue, make glycogen synthase activity
Increase and increase the sensitiveness of insulin, so as to play hypoglycemic effect.Meanwhile, the Radix Astragali can also strengthen body immunity.
CHAGA, alias Inonotus obliquus is a kind of medicinal fungi being grown on silver birch.CHAGA contains polysaccharide, terpene
A variety of effective ingredients such as class.The water-soluble polysaccharide extracted using CHAGA has significant hypoglycemic effect, is widely used and 2
The scientific research of patients with type Ⅰ DM and clinic.
Dendrobium candidum, contains polysaccharide and alkaloid isoreactivity composition.Dendrobium candidum can promote internal pancreaticβ-cell number
Amount increases to secrete more insulin, suppresses pancreas islet A cells secretion glucagons, and serum insulin level rise may also suppress
Hepatic glycogenolytic and promotion hepatic glycogen synthesis, therefore with good hypoglycemic ability.
In a word, liquid beverage, solid particle beverage or the effervescence tablet beverage prepared by the composition of the present invention has bright
Aobvious blood sugar decreasing effect.
Embodiment
Embodiment 1 to 6：The formula of hypoglycemic liquid beverage and solid beverage is shown in Table 1, and wherein embodiment 1 ~ 3 is liquid
Beverage, 4 ~ 6 be solid beverage.Beverage is prepared from using raw material in being formulated described in table 1.
Table 1：The each component composition of embodiment 1 ~ 6（Unit：Gram）
Embodiment 7 to 9：The formula of hypoglycemic effervescent tablet is shown in Table 2, and effervescent tablet is prepared from using raw material in being formulated described in table 2.
Table 2：The each component composition of embodiment 7 ~ 9（Unit：Gram）
For a further understanding of the present invention, the present invention is described in further detail with reference to embodiment, but should be managed
Solution, these descriptions are simply to further illustrate the features and advantages of the present invention, rather than limiting to the claimed invention.
Embodiment 1
The liquid beverage of auxiliary hyperglycemic is prepared, including the aqueous extract and L-arabinose that are prepared by the following raw material are mixed with
Form.The weight of each component is respectively：30 grams of mulberry leaf, 15 grams of eucommia Bark male flower, 15 grams of Qingqian Willow leaf, 6 grams of corn stigma, 8 grams of the Radix Astragali,
6 grams of CHAGA, 6 grams of dendrobium candidum, 10 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic liquid beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 4300 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
10 grams of L-arabinoses are added into above-mentioned aqueous extract, are well mixed, sterilized, packing produces liquid beverage.
Embodiment 2
The liquid beverage of auxiliary hyperglycemic is prepared, including the aqueous extract and L-arabinose that are prepared by the following raw material are mixed with
Form.The weight of each component is respectively：50 grams of mulberry leaf, 10 grams of eucommia Bark male flower, 20 grams of Qingqian Willow leaf, 10 grams of corn stigma, the Radix Astragali 5
Gram, 5 grams of CHAGA, 10 grams of dendrobium candidum, 8 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic liquid beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 6600 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
8 grams of L-arabinoses are added into above-mentioned aqueous extract, are well mixed, sterilized, packing produces liquid beverage.
Embodiment 3
The liquid beverage of auxiliary hyperglycemic is prepared, including the aqueous extract and L-arabinose that are prepared by the following raw material are mixed with
Form.The weight of each component is respectively：20 grams of mulberry leaf, 20 grams of eucommia Bark male flower, 10 grams of Qingqian Willow leaf, 5 grams of corn stigma, the Radix Astragali 10
Gram, 10 grams of CHAGA, 5 grams of dendrobium candidum, 12 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic liquid beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 8000 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
12 grams of L-arabinoses are added into above-mentioned aqueous extract, are well mixed, sterilized, packing produces liquid beverage.
Embodiment 4
Prepare the solid particle beverage of auxiliary hyperglycemic, including aqueous extract and the L-arabinose mixing prepared by the following raw material
It is prepared from.The weight of each component is respectively：35 grams of mulberry leaf, 15 grams of eucommia Bark male flower, 15 grams of Qingqian Willow leaf, 6 grams of corn stigma, the Radix Astragali
8 grams, 6 grams of CHAGA, 5 grams of dendrobium candidum, 10 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic solid particle beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 1720 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.20 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
10 grams of 12 grams of dextrin and L-arabinose are well mixed, and are spray-dried, and sterilizing, packing obtain solid particle beverage, specification
For 2.0 grams/bag.
Embodiment 5
Prepare the solid particle beverage of auxiliary hyperglycemic, including aqueous extract and the L-arabinose mixing prepared by the following raw material
It is prepared from.The weight of each component is respectively：50 grams of mulberry leaf, 10 grams of eucommia Bark male flower, 20 grams of Qingqian Willow leaf, 8 grams of corn stigma, the Radix Astragali
5 grams, 8 grams of CHAGA, 10 grams of dendrobium candidum, 8 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic solid particle beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 1100 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 50 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.30 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
8 grams of 15 grams of dextrin and L-arabinose are well mixed, and are spray-dried, and sterilizing, packing obtain solid particle beverage, and specification is
2.0 gram/bag.
Embodiment 6
Prepare the solid particle beverage of auxiliary hyperglycemic, including aqueous extract and the L-arabinose mixing prepared by the following raw material
It is prepared from.The weight of each component is respectively：25 grams of mulberry leaf, 20 grams of eucommia Bark male flower, 10 grams of Qingqian Willow leaf, 5 grams of corn stigma, the Radix Astragali
10 grams, 10 grams of CHAGA, 7 grams of dendrobium candidum, 12 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic solid particle beverage, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 4350 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.30 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
12 grams of 18 grams of dextrin and L-arabinose are well mixed, and are spray-dried, and sterilizing, packing obtain solid particle beverage, specification
For 2.0 grams/bag.
Embodiment 7
Prepare the effervescent tablet of auxiliary hyperglycemic, including the aqueous extract and L-arabinose prepared by the following raw material be mixed with and
Into.The weight of each component is respectively：It is 40 grams of mulberry leaf, 15 grams of eucommia Bark male flower, 15 grams of Qingqian Willow leaf, 6 grams of corn stigma, 7 grams of the Radix Astragali, white
Birch is fine and soft 6 grams, 6 grams of dendrobium candidum, 10 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic effervescent tablet, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 1720 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.20 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
10 grams of 12 grams of dextrin and L-arabinose are well mixed, and progress, which is spray-dried, obtains solid particle；
The solid particle of 2 parts of identical weights is taken, a copy of it adds 13.65 grams of mixings of citric acid, and spray mass concentration is 10% poly- second
Alkene pyrrolidone（PVP）Acid grain is made in ethanol solution, and another adds 20.80 grams of mixings of sodium acid carbonate, and spray mass concentration is
10% polyvinylpyrrolidone（PVP）Alkaline grain is made in ethanol solution；
Above-mentioned acid grain and alkaline grain are dried under 60 °C respectively, then they are uniformly mixed, poly- second two is added
2.60 grams of alcohol is stirred and evenly mixed, through tabletting, sterilizing, thus obtaining the product effervescent tablet, and specification is 1.2 grams/piece.
Embodiment 8
Prepare the effervescent tablet of auxiliary hyperglycemic, including the aqueous extract and L-arabinose prepared by the following raw material be mixed with and
Into.The weight of each component is respectively：45 grams of mulberry leaf, 10 grams of eucommia Bark male flower, 20 grams of Qingqian Willow leaf, 10 grams of corn stigma, 8 grams of the Radix Astragali,
5 grams of CHAGA, 10 grams of dendrobium candidum, 8 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic effervescent tablet, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 1100 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 50 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.30 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
8 grams of 15 grams of dextrin and L-arabinose are well mixed, and progress, which is spray-dried, obtains solid particle；
The solid particle of 2 parts of identical weights is taken, a copy of it adds 14.07 grams of mixings of citric acid, and spray mass concentration is 10% poly- second
Alkene pyrrolidone（PVP）Acid grain is made in ethanol solution, and another adds 21.44 grams of mixings of sodium acid carbonate, and spray mass concentration is
10% polyvinylpyrrolidone（PVP）Alkaline grain is made in ethanol solution；
Above-mentioned acid grain and alkaline grain are dried under 60 °C respectively, then they are uniformly mixed, poly- second two is added
2.68 grams of alcohol is stirred and evenly mixed, through tabletting, sterilizing, thus obtaining the product effervescent tablet, and specification is 1.2 grams/piece.
Embodiment 9
Prepare the effervescent tablet of auxiliary hyperglycemic, including the aqueous extract and L-arabinose prepared by the following raw material be mixed with and
Into.The weight of each component is respectively：38 grams of mulberry leaf, 20 grams of eucommia Bark male flower, 10 grams of Qingqian Willow leaf, 5 grams of corn stigma, 10 grams of the Radix Astragali,
8 grams of CHAGA, 5 grams of dendrobium candidum, 12 grams of L-arabinose.
The preparation method of above-mentioned auxiliary hyperglycemic effervescent tablet, step is as follows：
By mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum, impurity is removed in first pretreatment, point
Do not weighed according to above-mentioned weight, each component is then mixed to get mixture material, 4700 grams of drinking water is added, under 100 °C
Decoct and extract 2 times, decoct extract 60 minutes every time, obtain filtrate, aqueous extract is made through filtering in merging filtrate；
Above-mentioned aqueous extract is concentrated under reduced pressure, it is 1.25 to be concentrated into concentrate relative density, obtains concentrate, then adds malt
12 grams of 18 grams of dextrin and L-arabinose are well mixed, and progress, which is spray-dried, obtains solid particle；
The solid particle of 2 parts of identical weights is taken, a copy of it adds 18.90 grams of mixings of citric acid, and spray mass concentration is 10% poly- second
Alkene pyrrolidone（PVP）Acid grain is made in ethanol solution, and another adds 28.80 grams of mixings of sodium acid carbonate, and spray mass concentration is
10% polyvinylpyrrolidone（PVP）Alkaline grain is made in ethanol solution；
Above-mentioned acid grain and alkaline grain are dried under 60 °C respectively, then they are uniformly mixed, poly- second two is added
3.60 grams of alcohol is stirred and evenly mixed, through tabletting, sterilizing, thus obtaining the product effervescent tablet, and specification is 1.2 grams/piece.
Embodiment 10：Effect example, hypoglycemic effect（Human experimentation）
1st, experiment purpose
Drink alleviation and improvement result of the beverage of the present invention to diabetic;
2nd, experimental subjects
Selection suffer from the patient of diabetes, age between 40 years old~65 years old, totally 180, wherein man 36, female 24.It is divided into 3
Group, every group 60.Patient meets the World Health Organization（WHO）The diabetes diagnostic criterion of formulation;
3rd, laboratory sample and method
Experimental group is divided into 1,2,3 groups, embodiment 1 is taken respectively（Liquid beverage）, embodiment 4（Solid beverage）With embodiment 7（Bubble
Rise piece）Sample.Instructions of taking is that liquid beverage directly drinks 100 ml, daily oral 3 times；Solid particle beverage is left with 200 ml
Right boiling water, which is brewed, to be drunk, 1 bag every time, daily oral 3 times；Effervescent tablet is brewed with 200 ml or so boiling water and drunk, and 2 tablets once, often
Oral 3 times of day.While above-mentioned hypoglycemic beverage is taken, be careful in one's diet control;
It 2 weeks is 1 course for the treatment of that every kind of laboratory sample, which is taken, tries out 2 courses for the treatment of.Before taking and take evacuation abdomen vein after 2 courses for the treatment of
Hematometry blood glucose, while carrying out between liver function, hemorheology and routine urianlysis, each group patient blood before age, sex, treatment
Sugar level is average, and there was no significant difference, the medicine of unused influence blood glucose;
4th, efficacy assessment standard
With reference to Ministry of Health of the People's Republic of China《New Chinese medicine guideline of clinical investigations》Middle curative effect judging standard, it is effective：It is empty
Abdomen blood glucose is down to 7.2 mmol/L or reduction by 30%, substantially clinical symptom disappearance or mitigation；Effectively：8.25 mmol/L or reduction
10% ~ 29%, clinical symptoms are obviously improved；It is invalid：Fasting blood-glucose is unchanged or reduction by less than 10%, and clinical symptoms improve not clear
Show or without improvement;
5th, blood sugar decreasing effect
Statistical method：Examined using t
Embodiment 11：Effect example, the effect of auxiliary hyperglycemic（Zoopery）
1st, data and method
Using mouse as subjects, positive controls, beverage group of the present invention are processed into（The liquid drink that embodiment 1 is obtained
Material）, normal blank control group（First two groups are all injected 1 % alloxans, and the 3rd group is not injected）, continuous 30 days (d) is determined
Fasting blood sugar, compares each group animal blood glucose value and blood glucose rate of descent;
ICR is sheerly male white mouse（20±5）g（6 week old）, in order to reduce individual difference, selected same batch health
ICR mouse without other any influence result of the test diseases are used as subjects.Shadow is not taken to any one subjects
Ring the sugar and other drugs of blood sugar level.From the birth of ICR mouse to on-test, fed always in barrier environment with basal feed
Support.Mouse feeder environment：5/cage of mouse, is raised in standardization Animal House, the adaptation d of environment 4, free water acquisition, feeding,
Room ventilation condition is good, normal day-night change, relative humidity 50%~70%, 18~25 DEG C of room temperature;
Weigh the liquid beverage prepared in embodiment 1, gavage, the mL/d of gavage amount 0.40.Take normal ICR mouse, fasting
（Normal water）After 24 h, 1% alloxan is injected intraperitoneally（200 mg/kg）Normal saline solution, recovers normal drink after injection
Food.The h of fasting 8 after 3 d, determines animal fasting plasma glucose concentration, it is experiment patients with type Ⅰ DM that blood glucose value, which is more than 11.1 mmol/L persons,
Model;
Blood is taken because mouse blood amount is less, therefore using eyeball, is collected in centrifuge tube, is centrifuged in half an hour（5000 r/
Min, 10 min）After take and determine its absorbance under serum supernatant, 505 nm;
Select hyperglycemia model animal and be grouped by the h of fasting 8 blood sugar level, 1 model control group and 1 agent are selected at random
Amount group（Difference is not more than 1.1 mmol/L between group）, while choosing a normal blank group.Positive controls and beverage of the present invention
Group all injects 1% alloxan, and blank control group is not injected.Continuous 30 d, surveys fasting blood sugar（Before fasting is with experiment）,
Compare each group animal blood glucose value and blood glucose declines percentage;
Blood glucose declines percentage=(model group blood glucose-treatment group blood glucose)/model group blood glucose × 100%;
2nd, experimental result
Blood sugar effects are shown in Table 5. by the hypoglycemic beverage of the present invention
The above results show, are compared with model control group, and diabetes caused by beverage of the invention can substantially suppress alloxan are small
The blood glucose rise of mouse, with preferable blood sugar decreasing effect.
Claims (6)
1. a kind of composition of auxiliary hyperglycemic, it is characterised in that be made up of the raw material of following parts by weight：20 ~ 50 parts of mulberry leaf,
10 ~ 20 parts of eucommia Bark male flower, 10 ~ 20 parts of Qingqian Willow leaf, 5 ~ 10 parts of corn stigma, 5 ~ 10 parts of the Radix Astragali, CHAGA 5 ~ 10
5 ~ 10 parts of part and dendrobium candidum.
2. the composition of a kind of auxiliary hyperglycemic according to claim 1, it is characterised in that by the raw material of following parts by weight
Composition：30 parts of mulberry leaf, 15 parts of eucommia Bark male flower, 15 parts of Qingqian Willow leaf, 6 parts of corn stigma, 8 parts of the Radix Astragali, 6 parts of CHAGA and dendrobium candidum
6 parts.
3. a kind of beverage of auxiliary hyperglycemic, it is characterised in that including as a kind of auxiliary hyperglycemic described in claim 1 and 2
Composition in mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum and appropriate food additives
The liquid beverage or solid particle or effervescent tablet being mixed.
4. a kind of preparation method of auxiliary hyperglycemic liquid beverage, it is characterised in that comprise the following steps：
Step（1）, according to the weight ratio point of each raw material in a kind of auxiliary hyperglycemic composition described in claim 1 or 2
Also known as take each raw material；
Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 50 ~ 200 times of water of the mixture material total weight parts, extraction 2 times is decocted under 100 °C, every time
Decoct and extract 15 ~ 90 minutes, obtain filtrate, aqueous extract A is made through filtering in merging filtrate；
Step（3）, to step（2）Appropriate L-arabinose is added in gained aqueous extract A, is well mixed, sterilized, packing is
Obtain liquid beverage.
5. a kind of preparation method of auxiliary hyperglycemic solid particle beverage, it is characterised in that comprise the following steps：
Step（1）, according to the weight ratio point of each raw material in a kind of auxiliary hyperglycemic composition described in claim 1 or 2
Also known as take each raw material；
Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 10 ~ 50 times of water of the mixture material total weight parts, decocts and extracts 2 times under 100 °C, decocts every time
Boil extraction 30 ~ 120 minutes, obtain filtrate, aqueous extract B is made through filtering in merging filtrate；
Step（3）, by step（2）The aqueous extract B of gained, through being concentrated under reduced pressure, be concentrated into concentrate relative density for 1.20 ~
1.30, concentrate is obtained, appropriate maltodextrin is then added and L-arabinose is well mixed, be spray-dried, sterilize, divide
Dress obtains solid particle beverage.
6. a kind of preparation method of auxiliary hyperglycemic effervescent tablet, it is characterised in that comprise the following steps：
Step（1）, according to the weight ratio point of each raw material in a kind of auxiliary hyperglycemic composition described in claim 1 or 2
Also known as take each raw material；
Step（2）, mulberry leaf, eucommia Bark male flower, Qingqian Willow leaf, corn stigma, the Radix Astragali, CHAGA, dendrobium candidum are mixed to get mixing
Raw material, then adds 10 ~ 50 times of water of the mixture material total weight parts, decocts and extracts 2 times under 100 °C, decocts every time
Boil extraction 30 ~ 120 minutes, obtain filtrate, aqueous extract C is made through filtering in merging filtrate；
Step（3）, by step（2）The aqueous extract C of gained, through being concentrated under reduced pressure, be concentrated into concentrate relative density for 1.20 ~
1.30, concentrate is obtained, appropriate maltodextrin is then added and L-arabinose is well mixed, be spray-dried, consolidate
Body particle A；
Step（4）, the step of taking 2 parts of identical weights（3）Gained solid particle A, a copy of it adds citric acid and mixed, and sprays quality
Concentration is 10% polyvinylpyrrolidone（PVP）Acid grain is made in ethanol solution, and another adds sodium acid carbonate and mixed, and sprays matter
Measure the polyvinylpyrrolidone that concentration is 10%（PVP）Alkaline grain is made in ethanol solution；
Step（5）, respectively by step（4）The acid grain of gained and alkaline grain are dried under 60 °C, are then stirred them and are mixed
Uniformly, add appropriate Macrogol 6000 to stir and evenly mix, through tabletting, sterilizing, thus obtaining the product effervescent tablet.
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| CN107853506A (en) * | 2017-09-26 | 2018-03-30 | 伊春林业科学院 | Fine and soft hypoglycemic drink formula and processing technology |
| CN107898932A (en) * | 2017-11-15 | 2018-04-13 | 上海扬坊生物科技有限公司 | A kind of stem of noble dendrobium multidimensional composite nutrient and preparation method thereof |
| CN108576346A (en) * | 2018-03-30 | 2018-09-28 | 李乃彬 | A kind of Inonotus obliquus pressed candy of energy anticancer reducing pressure and sugar reducing blood lipid |
| CN110604244A (en) * | 2019-09-22 | 2019-12-24 | 吉林市誉翔商贸有限公司 | Hypoglycemic solid beverage and preparation method thereof |
| CN112205559A (en) * | 2020-10-20 | 2021-01-12 | 山东贝隆杜仲生物工程有限公司 | Composition containing eucommia ulmoides and mulberry leaves and application |
| CN112315972A (en) * | 2020-09-11 | 2021-02-05 | 唐传生物科技（厦门）有限公司 | Composition for preparing intestinal tract |
| CN112515078A (en) * | 2020-11-13 | 2021-03-19 | 安康汉阴华晔植物药业有限公司 | Organic selenium radix puerariae and folium mori solid beverage and preparation method thereof |
| CN113455563A (en) * | 2021-06-17 | 2021-10-01 | 湖北瑞邦生物科技有限公司 | Mulberry leaf peptide composite solid beverage and preparation method and application thereof |
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