CN105639637A - Health care food with blood sugar reduction function - Google Patents

Health care food with blood sugar reduction function Download PDF

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Publication number
CN105639637A
CN105639637A CN201610070439.0A CN201610070439A CN105639637A CN 105639637 A CN105639637 A CN 105639637A CN 201610070439 A CN201610070439 A CN 201610070439A CN 105639637 A CN105639637 A CN 105639637A
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parts
fructus
health food
add
ethanol
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林爱玉
杨芳
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention relates to health care food with a blood sugar reduction function, and belongs to the technical field of food processing. The health care food is made from rhizoma Polygonati Odorati, clove, hawthorn, balloon flowers, poria cocos, fructus lycii, cape jasmine , chia seeds, jujubes, chrysanthemum flowers, mulberry leaves and galacto-oligosaccharides. The raw materials of the health care food are carefully selected, the health care food is scientific in formula, has a blood sugar reduction health care effect, and has health care effects of maintaining beauty, keeping young, preventing hypertension and hyperlipidemia, resisting oxidation, delaying senescence, improving immunity, and the like.

Description

A kind of health food with function of blood sugar reduction
Technical field
The present invention relates to a kind of health food with function of blood sugar reduction, belong to food processing technology field.
Background technology
Along with economic fast development, living standards of the people increase substantially, and the incident people of being suffer from hyperglycemia, the probability of hyperlipidemia also rises rapidly. In health food, blood sugar lowering, blood fat reducing health food increasingly by the liking of people. Hyperlipidemia, hypercholesterolemia, hypertension, hyperglycemia are all present epidemic diseases, and blood fat reducing blood pressure lowering becomes a hot issue. According to statistics, the whole world there are about 1.5 hundred million diabeticss, and 80% is non-insulin-dependent diabetes mellitus and type ii diabetes, and wherein China has more than 4,000 ten thousand. At present the treatment of diabetes mainly there are chemicals and treatment by Chinese herbs two kinds, although chemicals is main drug application now, but owing to islets of langerhans also can be had good repair hypoglycemic by Chinese medicine simultaneously, treating diabetes has good prospect. Due to diabetes all the life can not the reason such as side effect of healing property and drug resistance, Drug resistance and medicine, this kind of crowd is very big to the demand of blood-sugar lowering type health-care food. Type ii diabetes is also called non-insulin-dependent diabetes mellitus, and hyperglycemia is its cardinal symptom, controls blood glucose and can obviously improve generation and the development of complication. Existing market demand is a kind of can the health food of safe blood sugar lowering of long-term taking.
Summary of the invention
For solving above-mentioned technical problem, present invention aim at providing a kind of health food with function of blood sugar reduction. This health food, by meticulously selecting raw material, scientific composition, not only has hypoglycemic health-care effect, also has the health-care effects such as looks improving and the skin nourishing, prophylaxis of hypertension, hyperlipemia, antioxidation, slow down aging, raising immunity.
Realize the object of the invention technical scheme as follows:
A kind of health food with function of blood sugar reduction, its raw material includes Rhizoma Polygonati Odorati, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose.
Preferably, described health food, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 10-200 part, Flos Caryophylli 1-10 part, Fructus Crataegi 5-50 part, Radix Platycodonis 10-200 part, Poria 5-50 part, Fructus Lycii 10-150 part, Fructus Gardeniae 5-20 part, Salvia Hispanica L. 5-100 part, Fructus Jujubae 5-50 part, Flos Chrysanthemi 10-200 part, Folium Mori 5-100 part, oligomeric galactose 0.1-1 part.
Further preferably, described health food, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 50-150 part, Flos Caryophylli 2-8 part, Fructus Crataegi 10-40 part, Radix Platycodonis 50-150 part, Poria 10-40 part, Fructus Lycii 50-120 part, Fructus Gardeniae 10-15 part, Salvia Hispanica L. 10-80 part, Fructus Jujubae 10-40 part, Flos Chrysanthemi 50-150 part, Folium Mori 10-80 part, oligomeric galactose 0.2-0.8 part.
Preferably, described health food, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 120 parts, Flos Caryophylli 3 parts, Fructus Crataegi 15 parts, Radix Platycodonis 70 parts, 15 parts of Poria, Fructus Lycii 80 parts, Fructus Gardeniae 12 parts, Salvia Hispanica L. 50 parts, 30 parts of Fructus Jujubae, Flos Chrysanthemi 85 parts, 60 parts of Folium Mori, oligomeric galactose 0.6 part.
Described weight portion can be the unit of weights well known in the art such as �� g, mg, g, kg, it is also possible to is its multiple, such as 1/10,1/100,10 times, 100 times etc.
The above-mentioned health food with function of blood sugar reduction, wherein Rhizoma Polygonati Odorati, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose is as active raw materials; Preferably, its raw material of above-mentioned health food or adjuvant also include pharmaceutically or acceptable carrier on food or on health food.
Preferably, described health food is formed into oral formulations; Including: capsule, granule, tablet, packed medicinal tea, powder etc.; It is more preferably granule.
It is further preferred that its raw material of described health food or adjuvant also include microcrystalline Cellulose, magnesium stearate.
The preparation method that the present invention also provides for above-mentioned health food, the method comprises the following steps: weigh each composition according to proportioning, and mixing, conventionally formulation method prepares into preparation.
Preferably, the preparation method of above-mentioned health food comprises the following steps:
1) dispensing; Namely needed raw material (including Rhizoma Polygonati Odorati, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose etc.) is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, add 50%-90% alcohol reflux 1-3 time of 5-10 times of weight, each 0.5-3.0 hour, filter, merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adding ethanol makes alcohol content reach 70%-75%, obtains solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, add soak by water 1-3 time of 5-15 times of weight, each 0.5-2 hour, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adding ethanol makes alcohol content reach 70%-75%, obtains solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10-1.30,30 DEG C); Add oligomeric galactose by formula and appropriate amount of auxiliary materials makes suitable dosage form. Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
Specifically, the preparation method of above-mentioned health food comprises the following steps:
1) dispensing; Namely needed raw material (including Rhizoma Polygonati Odorati, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose etc.) is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, with 70%-75% alcohol reflux 2 times, add 8 times of w ethanol 1st time and extract 3h, add 6 times of w ethanol 2nd time and extract 1h, filter, merging filtrate, (relative density is 1.10-1.30 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 70%-75%, obtain solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol for 2nd time and extract 1h, collecting decoction, filter, (relative density is 1.10-1.30 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 70%-75%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10-1.30,30 DEG C); Add oligomeric galactose by formula and appropriate amount of auxiliary materials makes suitable dosage form; Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
If no special instructions, concentration of alcohol of the present invention refers both to volumetric concentration.
Experiment proves, the present invention adopts above-mentioned technique that traditional Chinese medicinal material raw materials is extracted, and at utmost remains the active ingredient of raw material of Chinese medicine, and the effective ingredient extracted is easiest to be absorbed by the body, strengthen the absorption of medicine, thus the problem avoiding invalid components interference drug effect.
What the raw material Rhizoma Polygonati Odorati of the health food with function of blood sugar reduction of the present invention, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose were that national legal permission uses is food and the article of medicine; All meet the standard-requireds such as pharmacopeia, all can obtain from commercially available.
Wherein, Salvia Hispanica L. (ChiaSeed) has another name called strange refined son, Salvia Hispanica L. seed, formal name used at school salvia hispanica L (SalviaHispanicaL.), pennyroyal, and original producton location is the areas, North America such as Mexico south and Guatemala. Salvia Hispanica L. of the present invention refers to the seed Salvia Hispanica L. seed of this plant. Salvia Hispanica L. it be enriched in the food that omega-3 fatty acid is the abundantest, and containing the Natural antioxidant. Beyond common anti-oxidizing elements (vitamin E, C and lecithin), Salvia Hispanica L. seed is contained within the more rich Natural antioxidant, is the required of anti-ageing diseases prevention anti-cancer: caffeic acid (caffeicacid) can harden by prevention of arterial; Chlorogenic acid (chlorogenicacid) effectively suppresses canceration, and has antiobesity action; Other antioxidant is oak doradexanthin (quercetin) such as, and Kaempferol (kaempferol) etc. is also anti-cancer, aging-resistant active substance.
The present invention is with Chinese Traditional Medicine theory for instructing, in conjunction with modern medicine study, meticulously select raw material, scientific composition from health preserving angle, reach hypoglycemic health-care effect, additionally also there is skin maintenance, keep fit life, the health care of health invigorating, prevention disease, life lengthening. The present invention focuses on the overall conditioning of human body and inherent conditioning, and the health food developed in conjunction with health preserving not only has hypoglycemic health-care effect, additionally it is possible to promote the good health and a long life of human body.
The principles of formulating prescriptions of the present invention: with Rhizoma Polygonati Odorati, Radix Platycodonis for monarch, with Fructus Crataegi, Poria, Fructus Lycii for minister, with Flos Caryophylli, Flos Chrysanthemi, Folium Mori for assistant, with Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, oligomeric galactose for making, to assist raising hypoglycemic effect of product. All medicines share, play altogether relieve heat and thirst, YIN nourishing and the production of body fluid promoting, nourshing Yin and drynsessmoistening prescription and have effect of lung moistening, clearing stomach, nourishing kidney concurrently; And have benefiting QI for activating blood circulation, effect of eliminating toxin and beautifying the skin, can skin smoothing skin moistening, happy pool face. Selected raw material of the present invention conditioning human five internal organs, comprehensive function reaches the health-care effect of lowering blood sugar and preventing thirst. Wherein making the motive vigorous by conditioning heart, painstaking effort fill; Liver storing blood, makes QI and blood gentle by nursing one's health liver; The spleen being the foundation of acquired constitution, source of generating QI and blood; Passing through function of spleen and stomach regulating so that it is the strong fortune of function, QI and blood is vigorous; Lung governing skin and hair, makes qi-blood-body fluid be able to spreading whole body by nursing one's health lung; Kidney controlling essence storage, by nursing one's health kidney, makes kidney essense fill, and when kidney qi is vigorous, function of five internal organs is also by properly functioning, and QI and blood is vigorous, body-building.
Health food of the present invention is a kind of to follow the fashion, take into account traditional product drink mode again, reaches to be of value to person in middle and old age and the purpose of sub-health population health care in satisfied.Health food action temperature of the present invention and, efficacy stability, have no side effect, be suitable for long-term drink. Research finds, long-term taking health food of the present invention also has the health-care effects such as prophylaxis of hypertension, hyperlipemia, antioxidation, slow down aging, raising immunity.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention. Unreceipted concrete technology or condition person in embodiment, technology described by the document in this area or condition, or carry out according to product description. Agents useful for same or the unreceipted production firm person of instrument, be the conventional products can being commercially available by regular distributor.
Embodiment 1
A kind of health food with function of blood sugar reduction, includes Rhizoma Polygonati Odorati 10 parts, Flos Caryophylli 1 part, Fructus Crataegi 5 parts, Radix Platycodonis 10 parts, 5 parts of Poria, Fructus Lycii 10 parts, Fructus Gardeniae 5 parts, Salvia Hispanica L. 5 parts, 5 parts of Fructus Jujubae, Flos Chrysanthemi 10 parts, 5 parts of Folium Mori, oligomeric galactose 0.1 part with its raw material of parts by weight.
Embodiment 2
A kind of health food with function of blood sugar reduction, includes Rhizoma Polygonati Odorati 200 parts, Flos Caryophylli 10 parts, Fructus Crataegi 50 parts, Radix Platycodonis 200 parts, 50 parts of Poria, Fructus Lycii 150 parts, Fructus Gardeniae 20 parts, Salvia Hispanica L. 100 parts, 50 parts of Fructus Jujubae, Flos Chrysanthemi 200 parts, 100 parts of Folium Mori, oligomeric galactose 1 part with its raw material of parts by weight.
Embodiment 3
A kind of health food with function of blood sugar reduction, includes Rhizoma Polygonati Odorati 150 parts, Flos Caryophylli 2 parts, Fructus Crataegi 10 parts, Radix Platycodonis 150 parts, 10 parts of Poria, Fructus Lycii 120 parts, Fructus Gardeniae 10 parts, Salvia Hispanica L. 10 parts, 40 parts of Fructus Jujubae, Flos Chrysanthemi 150 parts, 80 parts of Folium Mori, oligomeric galactose 0.8 part with its raw material of parts by weight.
Embodiment 4
A kind of health food with function of blood sugar reduction, includes Rhizoma Polygonati Odorati 50 parts, Flos Caryophylli 8 parts, Fructus Crataegi 40 parts, Radix Platycodonis 50 parts, 40 parts of Poria, Fructus Lycii 50 parts, Fructus Gardeniae 15 parts, Salvia Hispanica L. 80 parts, 10 parts of Fructus Jujubae, Flos Chrysanthemi 50 parts, 10 parts of Folium Mori, oligomeric galactose 0.2 part with its raw material of parts by weight.
Embodiment 5
A kind of health food with function of blood sugar reduction, includes Rhizoma Polygonati Odorati 120 parts, Flos Caryophylli 3 parts, Fructus Crataegi 15 parts, Radix Platycodonis 70 parts, 15 parts of Poria, Fructus Lycii 80 parts, Fructus Gardeniae 12 parts, Salvia Hispanica L. 50 parts, 30 parts of Fructus Jujubae, Flos Chrysanthemi 85 parts, 60 parts of Folium Mori, oligomeric galactose 0.6 part with its raw material of parts by weight.
Embodiment 6
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 1, and the preparation method of this health food comprises the following steps:
1) dispensing; Namely needed raw material is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, add 90% alcohol reflux 3 times of 5 times of weight, each 0.5 hour, filter, merging filtrate, concentrates the filtrate to clear paste (relative density is 1.30,30 DEG C), adding ethanol makes alcohol content reach 75%, obtains solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, the soak by water 3 times of 5 times of weight is added, each 0.5 hour, collecting decoction, filters, and (relative density is 1.30 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 75%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.30,30 DEG C); Add oligomeric galactose by formula, prepare active mixture; Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag; Suggestion eating method and amount: every day 2 times, each 1 bag, warm boiled water; 24 months shelf-lifves; Storage practice room temperature, ventilation, dry place.
Embodiment 7
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 2, and the preparation method of this health food comprises the following steps:
1) dispensing; Namely needed raw material is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, add 50% alcohol reflux 1 time of 10 times of weight, each 3.0 hours, filter, merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10,30 DEG C), adding ethanol makes alcohol content reach 70%, obtains solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, the soak by water 1 time of 15 times of weight is added, each 2 hours, collecting decoction, filters, and (relative density is 1.10 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 70%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10,30 DEG C); Add oligomeric galactose by formula, prepare active mixture; Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag; Suggestion eating method and amount: every day 2 times, each 1 bag, warm boiled water; 24 months shelf-lifves; Storage practice room temperature, ventilation, dry place.
Embodiment 8
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 3, and the preparation method of this health food comprises the following steps:
1) dispensing; Namely needed raw material is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, with 70% alcohol reflux 2 times, add 8 times of w ethanol 1st time and extract 3h, add 6 times of w ethanol 2nd time and extract 1h, filter, merging filtrate, (relative density is 1.10 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 70%, obtain solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol for 2nd time and extract 1h, collecting decoction, filter, (relative density is 1.10 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 70%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10,30 DEG C); Add oligomeric galactose by formula, prepare active mixture; Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag; Suggestion eating method and amount: every day 2 times, each 1 bag, warm boiled water; 24 months shelf-lifves; Storage practice room temperature, ventilation, dry place.
Embodiment 9
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 5, and the preparation method of this health food comprises the following steps:
1) dispensing; Namely needed raw material is weighed by proportioning;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, with 75% alcohol reflux 2 times, add 8 times of w ethanol 1st time and extract 3h, add 6 times of w ethanol 2nd time and extract 1h, filter, merging filtrate, (relative density is 1.30 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 75%, obtain solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol for 2nd time and extract 1h, collecting decoction, filter, (relative density is 1.30 to concentrate the filtrate to clear paste, 30 DEG C), add ethanol and make alcohol content reach 75%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.30,30 DEG C); Add oligomeric galactose by formula, prepare active mixture; Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag; Suggestion eating method and amount: every day 2 times, each 1 bag, warm boiled water; 24 months shelf-lifves; Storage practice room temperature, ventilation, dry place.
Embodiment 10
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 4, and the preparation method of this health food is with embodiment 9.
Product specification 20g/ bag; Suggestion eating method and amount: every day 2 times, each 1 bag, warm boiled water; 24 months shelf-lifves; Storage practice room temperature, ventilation, dry place.
Embodiment 11
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 1, for the packed medicinal tea made according to a conventional method.
Embodiment 12
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 2, for the capsule made according to a conventional method.
Embodiment 13
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 3, and its preparation method includes first making prepared active mixture by the method for embodiment 8; Conventional method makes tablet again.
Embodiment 14
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 4, and its preparation method includes first making prepared active mixture by the method for embodiment 9; Conventional method makes capsule again.
Embodiment 15
A kind of health food with function of blood sugar reduction, its formula is identical with embodiment 5, and its preparation method includes first making prepared active mixture by the method for embodiment 8; Conventional method makes tablet again.
Comparative example
A kind of granule, includes Flos Caryophylli 3 parts, Fructus Crataegi 15 parts, 15 parts of Poria, Fructus Lycii 80 parts, Fructus Gardeniae 80 parts, Flos Chrysanthemi 85 parts, 60 parts of Folium Mori with its raw material of parts by weight; Its preparation method and embodiment 9 identical (but raw material does not include above-mentioned Chinese crude drug and oligomeric galactose).
Experimental example function of blood sugar reduction is tested
1, test crowd: select 100 adult type ��diabetes mellitus people, age 18-65 year, men and women half and half. Experimenter's inclusive criteria is, select age 18-65 year, diet control or stable disease after oral antidiabetic drug treatment, it is not necessary to change types of drugs and dosage, only take the adult type ��diabetes mellitus people of maintenance dose, fasting glucose >=7.8mmol/L or 2h-plasma glucose >=11.1mmol/L.
2, EXPERIMENTAL DESIGN and packet: by experimenter's blood sugar level, sex, age, the course of disease, kind of taking medicine is balanced is randomly divided into experimental group and matched group, often organizes 50 people.
3, test method: experimental group takes sample prepared by the embodiment of the present invention 9 every day, dosage is every day 2 times, and each 1 bag (20g/ bag), boiled water is drunk after brewing. Matched group takes granule prepared by comparative example, and matched group taking dose and method are identical with experimental group. 30 days test periods.To each experimenter by sex, age, different labor intensity, ideal body weight before test, specifying corresponding diet with reference to original living habit, adhere to diet control for each group during test, former medicament categories mediating recipe amount is constant.
4, functional observation: observe clinical symptoms during experimenter tests, and measure fasting glucose, post-prandial glycemia and glucose in urine.
5, result of the test
5.1 clinicing symptom observations
Table 1 clinical symptoms integration statistics (x �� s)
Group Number of cases Before test-meal After test-meal
Matched group 50 5.58��3.27 5.47��3.10
Experimental group 50 5.63��3.41 3.55��2.51*#
Note: * compares P < 0.05 with experimental group; # compares P < 0.05 with matched group.
Table 2 clinical symptoms improves situation
From table 1,2, experimental group clinical symptoms has clear improvement, and compares with matched group, significant difference (P < 0.05).
5.2 fasting glucose
Fasting glucose change (unit: mmol/L, x �� s) before and after table 3 test-meal
Note: * compares P < 0.05 with experimental group; # compares P < 0.05 with matched group.
5.3 post-prandial glycemia
Post-prandial glycemia change (unit: mmol/L, x �� s) before and after table 4 test-meal
Group number of cases (n) Before test-meal After test-meal Blood glucose fall Decline percentage rate %
Matched group 50 12.23��2.11 12.17��2.02 0.06��0.21 0.50
Experimental group 50 12.25��2.21 11.09��2.25*# 1.16��0.60*# 9.47
Note: * compares P < 0.05 with experimental group; # compares P < 0.05 with matched group
6, conclusion
Experimental group is taken the embodiment of the present invention 9 sample and is significantly improved for the main clinic symptoms of hyperglycemia; Experimental group fasting glucose, post-prandial glycemia and glucose in urine, self compare before and after test-meal and experimental group compare with matched group, and difference all has significance (P < 0.05). Result of the test shows, product of the present invention has hypoglycemic health-care effect.
This experimental example is taked the dosage form of granule, make drug administration simple and easy, effectively raise absorption and the utilization of medicine, additionally, what the present invention taked is pure natural medical, without any poisonous additive and addictive drug, will not appetite-suppressing, it is not result in diarrhoea, has no side effect, not addiction. Also finding during experiment, the body weight of major part experimental group experimenter alleviates to some extent, and blood fat, blood pressure have and reduce in various degree, and digestion all has improvement, and mental attitude significantly improves, and the prompting present invention also has the health-care effects such as blood fat reducing, blood pressure lowering and fat-reducing.
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.

Claims (9)

1. a health food with function of blood sugar reduction, it is characterised in that its raw material includes Rhizoma Polygonati Odorati, Flos Caryophylli, Fructus Crataegi, Radix Platycodonis, Poria, Fructus Lycii, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae, Flos Chrysanthemi, Folium Mori, oligomeric galactose.
2. health food according to claim 1, it is characterized in that, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 10-200 part, Flos Caryophylli 1-10 part, Fructus Crataegi 5-50 part, Radix Platycodonis 10-200 part, Poria 5-50 part, Fructus Lycii 10-150 part, Fructus Gardeniae 5-20 part, Salvia Hispanica L. 5-100 part, Fructus Jujubae 5-50 part, Flos Chrysanthemi 10-200 part, Folium Mori 5-100 part, oligomeric galactose 0.1-1 part.
3. health food according to claim 2, it is characterized in that, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 50-150 part, Flos Caryophylli 2-8 part, Fructus Crataegi 10-40 part, Radix Platycodonis 50-150 part, Poria 10-40 part, Fructus Lycii 50-120 part, Fructus Gardeniae 10-15 part, Salvia Hispanica L. 10-80 part, Fructus Jujubae 10-40 part, Flos Chrysanthemi 50-150 part, Folium Mori 10-80 part, oligomeric galactose 0.2-0.8 part.
4. health food according to claim 3, it is characterized in that, with parts by weight, its raw material includes Rhizoma Polygonati Odorati 120 parts, Flos Caryophylli 3 parts, Fructus Crataegi 15 parts, Radix Platycodonis 70 parts, 15 parts of Poria, Fructus Lycii 80 parts, Fructus Gardeniae 12 parts, Salvia Hispanica L. 50 parts, 30 parts of Fructus Jujubae, Flos Chrysanthemi 85 parts, 60 parts of Folium Mori, oligomeric galactose 0.6 part.
5. the health food according to any one of claim 1-4, it is characterised in that its raw material or adjuvant also include pharmaceutically or acceptable carrier on food or on health food.
6. the health food according to any one of claim 1-4, it is characterised in that described health food is formed into oral formulations; Including: capsule, granule, tablet, packed medicinal tea, powder.
7. the health food according to any one of claim 1-6, it is characterised in that its raw material of described health food or adjuvant also include microcrystalline Cellulose, magnesium stearate.
8. the preparation method of health food described in any one of claim 1-7, it is characterised in that comprise the following steps:
1) dispensing;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, 50%-90% alcohol reflux 1-3 time of 5-10 times of weight is added, each 0.5-3.0 hour, filter, merging filtrate, concentrate the filtrate to clear paste, adding ethanol makes alcohol content reach 70%-75%, obtains solution I;
3) by after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing, soak by water 1-3 time of 5-15 times of weight is added, each 0.5-2 hour, collecting decoction, filtration, concentrate the filtrate to clear paste, add ethanol and make alcohol content reach 70%-75%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste; Add oligomeric galactose by formula and appropriate amount of auxiliary materials makes suitable dosage form; Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
9. the preparation method of health food according to claim 8, it is characterised in that comprise the following steps:
1) dispensing;
2) by after Flos Caryophylli, Fructus Crataegi, Poria, Fructus Gardeniae, Salvia Hispanica L., Fructus Jujubae mixing, with 70%-75% alcohol reflux 2 times, add 8 times of w ethanol 1st time and extract 3h, add 6 times of w ethanol 2nd time and extract 1h, filter, merging filtrate, concentrate the filtrate to clear paste, adding ethanol makes alcohol content reach 70%-75%, obtains solution I;
3) after Rhizoma Polygonati Odorati, Radix Platycodonis, Fructus Lycii, Flos Chrysanthemi, Folium Mori being mixed, boiling 2 times, add 10 times of weight water the 1st time and decoct 2h, add 8 times of w ethanol for 2nd time and extract 1h, collecting decoction, filter, concentrate the filtrate to clear paste, add ethanol and make alcohol content reach 70%-75%, obtain solution II;
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste; Add oligomeric galactose by formula and appropriate amount of auxiliary materials makes suitable dosage form; Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
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CN101480473A (en) * 2008-01-07 2009-07-15 南京万舜源生物科技有限公司 Compound recipe for reducing blood sugar as well as preparation method and application
CN103638395A (en) * 2013-12-19 2014-03-19 青岛友铭辰生物技术有限公司 Traditional Chinese medicine tablet for regulating blood sugar and preparation method thereof
CN104288501A (en) * 2014-06-30 2015-01-21 广西健丰药业有限公司 Blood glucose reducing particle and preparation method thereof
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KR20090055103A (en) * 2007-11-28 2009-06-02 건국대학교 산학협력단 Salad composition for improving diabetes comprising garden products
CN101480473A (en) * 2008-01-07 2009-07-15 南京万舜源生物科技有限公司 Compound recipe for reducing blood sugar as well as preparation method and application
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* Cited by examiner, † Cited by third party
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