CN103638395A - Traditional Chinese medicine tablet for regulating blood sugar and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine tablet for regulating blood sugar and a preparation method thereof. The traditional Chinese medicine tablet is prepared from the following raw materials in parts by weight: 15-20 parts of cassia seeds, 10-15 parts of rhizoma polygonati, 8-14 parts of boxthorn leaves, 10-15 parts of hawthorns, 6-12 parts of radix notoginseng, 9-16 parts of radix puerariae, 5-10 parts of folium mori, 8-14 parts of gymnema sylvestre schult, 10-15 parts of rhizoma dioscoreae, 12-16 parts of poria cocos, 15-20 parts of stevia rebaudian leaves, 10-15 parts of radix astragali, 16-22 parts of cape jasmine, 10-15 parts of rhizoma coptidis, 5-10 parts of radix salviae miltiorrhizae, 10-15 parts of Niu Gengcao, 5-10 parts of radix rehmanniae, 14-18 parts of rhizoma anemarrhenae, 10-15 parts of cedrela sinensis, 5-10 parts of radix polygonati officinalis, 10-15 parts of herba agrimoniae, 5-10 parts of fructus hordei germinatus, 10-15 parts of rhizoma alismatis, 12-16 parts of platycodon grandiflorum, 14-18 parts of gynostemma pentaphylla, 10-15 parts of polygonum multiflorum. The drug disclosed by the invention can be used for effectively regulating the blood sugar content, reducing the blood sugar, achieving an outstanding effect on treating diabetes and preventing hyperglycemia, has the advantages of definiteness in drug effect, quick effect taking, short treatment course, no bounce or side effect and wide application prospect and is worthy of being clinically popularized.

Description

A kind of adjusting blood glucose Chinese medicinal tablet and preparation method thereof

Technical field

The present invention relates to a kind of adjusting blood glucose Chinese medicinal tablet and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Hyperglycemia is a kind of commonly encountered diseases, frequently-occurring disease, the serious harm mankind's health.Blood sugar increasing, glucose in urine increases, and can cause osmotic diuresis, thereby causes the symptom of polyuria; Blood sugar increasing, large quantity of moisture are lost, and blood osmotic pressure also can correspondingly raise, and high blood oozes thirst center that can Hypothalamic Stimulation, thereby causes symptom thirsty, polydipsia; Due to the relative or absolute shortage of insulin, cause glucose in body not to be utilized, protein and fat consumption increase, thus cause weak, lose weight; For the sugar of recovering damage, maintain body activity, need many feeds; This has just formed the modal polydipsia of diabetes, polyphagia, polyuria and " three-many-one-little " symptom that loses weight.Along with rhythm of life is accelerated, life stress strengthens, diabetics is more and more, and is rejuvenation trend, becomes the large killer that society threatens human life.At present commercially available adjusting blood glucose medicament categories is various, and effect is different, but most of curative effects are not remarkable, and treatment cycle is long, easily bounce-back.

Summary of the invention

In order to solve the deficiencies in the prior art, the object of the present invention is to provide that a kind of drug effect is definite, evident in efficacy, the adjusting blood glucose Chinese medicinal tablet that do not rebound, have no side effect and preparation method thereof.

For achieving the above object, the present invention adopts following technical scheme:

An adjusting blood glucose Chinese medicinal tablet, is made by the raw material of following weight portion: Semen Cassiae 15-20, Rhizoma Polygonati 10-15, Folium Lycii 8-14, Fructus Crataegi 10-15, Radix Notoginseng 6-12, Radix Puerariae 9-16, Folium Mori 5-10, Largeleaf Gymnema 8-14, Rhizoma Dioscoreae 10-15, Poria 12-16, Folium Chrysanthemi 15-20, Radix Astragali 10-15, Fructus Gardeniae 16-22, Rhizoma Coptidis 10-15, Radix Salviae Miltiorrhizae 5-10, the more careless 10-15 of cattle, Radix Rehmanniae 5-10, Rhizoma Anemarrhenae 14-18, Chinese toona flower 10-15, Rhizoma Polygonati Odorati 5-10, Herba Agrimoniae 10-15, Fructus Hordei Germinatus 5-10, Rhizoma Alismatis 10-15, Radix Platycodonis 12-16, Herb Gynostemmae Pentaphylli 14-18, Radix Polygoni Multiflori 10-15.

Preferably, an adjusting blood glucose Chinese medicinal tablet, is made by the raw material of following weight portion: Semen Cassiae 20, Rhizoma Polygonati 15, Folium Lycii 12, Fructus Crataegi 10, Radix Notoginseng 8, Radix Puerariae 13, Folium Mori 8, Largeleaf Gymnema 12, Rhizoma Dioscoreae 10, Poria 14, Folium Chrysanthemi 18, the Radix Astragali 15, Fructus Gardeniae 18, Rhizoma Coptidis 10, Radix Salviae Miltiorrhizae 7, cattle are more careless 10, Radix Rehmanniae 8, the Rhizoma Anemarrhenae 16, Chinese toona flower 10, Rhizoma Polygonati Odorati 8, Herba Agrimoniae 10, Fructus Hordei Germinatus 8, Rhizoma Alismatis 10, Radix Platycodonis 12, Herb Gynostemmae Pentaphylli 16, Radix Polygoni Multiflori 15.

A preparation method that regulates blood glucose Chinese medicinal tablet, comprises the following steps:

(1) depend on pine torch, Folium Lycii, Rhizoma Dioscoreae, Poria, the Radix Astragali, Rhizoma Polygonati Odorati, Herba Agrimoniae, Fructus Hordei Germinatus, Radix Platycodonis, Herb Gynostemmae Pentaphylli mix homogeneously, add 4-6 times of water gaging, decoct and extract 1-2h, filter, filtering residue adds 3-5 times of water gaging again, decocts and extracts 0.5-1h, filter, merging filtrate, standby;

(2) Chinese crude drug mix homogeneously under remainder, adds 5-8 doubly to measure 95% ethanol, reflux, extract, 2-3h, and standing over night, filters, and filtering residue adds 4-6 and doubly measures 80% ethanol, reflux, extract, 1-2h, standing over night, filters, and merging filtrate is standby;

(3) merge the above-mentioned reserve liquid making, standing 12-24h, filters, and filtrate recycling ethanol is also evaporated to the thick paste that relative density is 1.38-1.42, adds appropriate adjuvant, granulates, dry, tabletting, and coating, gets product.

Usage and consumption: oral, a 3-5 sheet, 2-3 time on the one.

Beneficial effect of the present invention:

The all medicines of the present invention share and can help to repair pancreas damaged cell, improve the secretory volume of insulin, promote pancreaticβ-cell regeneration, effectively suppress intestinal absorption to glycan molecule in digestion process, thereby effectively reduce sugared absorption, regulate blood sugar content, reduce blood glucose, remove free radical anti peroxidation of lipid, improve immunity of organisms, for treatment diabetes and prevention hyperglycemia, have significant effect, drug effect is definite, instant effect, short treating period, do not rebound, have no side effect, be with a wide range of applications, clinic is promoted.

The specific embodiment

An adjusting blood glucose Chinese medicinal tablet, is made by the raw material of following weight (g): Semen Cassiae 20, Rhizoma Polygonati 15, Folium Lycii 12, Fructus Crataegi 10, Radix Notoginseng 8, Radix Puerariae 13, Folium Mori 8, Largeleaf Gymnema 12, Rhizoma Dioscoreae 10, Poria 14, Folium Chrysanthemi 18, the Radix Astragali 15, Fructus Gardeniae 18, Rhizoma Coptidis 10, Radix Salviae Miltiorrhizae 7, cattle are more careless 10, Radix Rehmanniae 8, the Rhizoma Anemarrhenae 16, Chinese toona flower 10, Rhizoma Polygonati Odorati 8, Herba Agrimoniae 10, Fructus Hordei Germinatus 8, Rhizoma Alismatis 10, Radix Platycodonis 12, Herb Gynostemmae Pentaphylli 16, Radix Polygoni Multiflori 15.

A preparation method that regulates blood glucose Chinese medicinal tablet, comprises the following steps:

(1) depend on pine torch, Folium Lycii, Rhizoma Dioscoreae, Poria, the Radix Astragali, Rhizoma Polygonati Odorati, Herba Agrimoniae, Fructus Hordei Germinatus, Radix Platycodonis, Herb Gynostemmae Pentaphylli mix homogeneously, add 5 times of water gagings, decoct and extract 1h, filter, filtering residue adds 3 times of water gagings again, decocts and extracts 0.5h, filter, and merging filtrate, standby;

(2) Chinese crude drug mix homogeneously under remainder, adds 6 times of amount 95% ethanol, reflux, extract, 2h, and standing over night, filters, and filtering residue adds 4 times of amount 80% ethanol, reflux, extract, 1h, standing over night, filters, and merging filtrate is standby;

(3) merge the above-mentioned reserve liquid making, standing 24h, filters, and filtrate recycling ethanol to be evaporated to relative density be 1.40 thick paste adds appropriate adjuvant, granulates, dry, tabletting, and coating, gets product.

Usage and consumption: oral, a 3-5 sheet, 2-3 time on the one.

Model case:

Case 1: Lee, female, 58 years old.Diabetes medical history 6 years, does not tolerate metformin, acarbose, control blood glucose at ordinary times, but poor blood glucose control is repeatedly checked glycolated hemoglobin in 8% left and right from taking novolin.The present seeks medical advice because of the bad here then of glycemic control, haves a medical check-up and sees that patient's body is partially thin, remaining Non Apparent Abnormality.Fasting glucose 9mmol/L, glycolated hemoglobin 8%, insulin c peptide level is lower slightly, and routine urinalysis etc. are normal.Taken tablet of the present invention, taken after 12 days, check fasting glucose 7.2mmol/L, glycolated hemoglobin 6.8%, continued to take medicine after 15 days, and blood sugar recovery is normal, check fasting glucose 5.4mmol/L, glycolated hemoglobin 6.2%.Follow up a case by regular visits to so far, blood glucose is normal, not bounce-back.

Case 2: Zhao, man, 28 years old.Because of xerostomia, polydipsia, polyuria, become thin, over weak 5 days, examine.Before 5 days there is xerostomia, polydipsia, polyuria, malaise, conscious heating without obvious inducement in patient.Companion is nervous, and invalid through certain hospitalize, the state of an illness increases the weight of gradually, and there is dysphoria, and weight loss approximately 10 kg, here is medical then, look into FPG 86.2mmol/L, HbA1c 9.4%, glucose in urine +++, bradykinesia, dysphoria, flushed face, xerosis cutis poor flexibility, dicoria is sensitive to luminous reflectance, and neck is soft, two lungs are without rale, and the rhythm of the heart is neat, and hear sounds is low.Does not hear and noise each auscultatory valve areas.Abdominal part is bulge slightly, and abdomen is soft without tenderness and rebound tenderness, liver spleen end lay one's hand on and. two lower limb pneumonedema, acra is warm.Be diagnosed as hyperglycemia hyperosmolality syndrome.Taken tablet of the present invention, take medicine after 10 days, FPG is reduced to 12.8mmol/L, and HbA1c is reduced to 8.1%, continues to take medicine after 15 days, and blood sugar recovery is normal, and check FPG is 5.98mmol/L, and HbA1c is 6.4%.Follow up a case by regular visits to so far glucostasis, not bounce-back.

Case 3: high certain, man, 47 years old.Patient before 10 years health check-up find on an empty stomach and post-prandial glycemia raises, be interrupted and have the symptoms such as xerostomia, polydipsia, polyuria, do not keep on a diet, rule Monitoring Blood Glucose and regular treatment, it is even that to survey blood glucose many between 10-20mmol/L.Nearly 1 month because dizziness increases the weight of, accompany weak, feel sick, vomiting, abdominal distention.Then here is medical, looks into FPG 12.4mmol/L, and HbA1c 8.2%.Taken tablet of the present invention, taken medicine after 15 days, check FPG 8.2mmol/L, HbA1c 7.1%, continues to take medicine after 15 days, check FPG 5.6mmol/L, HbA1c 6.3%, and blood sugar recovery is normal.Follow up a case by regular visits to so far, blood glucose is normal, not bounce-back.

Claims (3)

1. one kind regulates blood glucose Chinese medicinal tablet, it is characterized in that, raw material by following weight portion is made: Semen Cassiae 15-20, Rhizoma Polygonati 10-15, Folium Lycii 8-14, Fructus Crataegi 10-15, Radix Notoginseng 6-12, Radix Puerariae 9-16, Folium Mori 5-10, Largeleaf Gymnema 8-14, Rhizoma Dioscoreae 10-15, Poria 12-16, Folium Chrysanthemi 15-20, Radix Astragali 10-15, Fructus Gardeniae 16-22, Rhizoma Coptidis 10-15, Radix Salviae Miltiorrhizae 5-10, the more careless 10-15 of cattle, Radix Rehmanniae 5-10, Rhizoma Anemarrhenae 14-18, Chinese toona flower 10-15, Rhizoma Polygonati Odorati 5-10, Herba Agrimoniae 10-15, Fructus Hordei Germinatus 5-10, Rhizoma Alismatis 10-15, Radix Platycodonis 12-16, Herb Gynostemmae Pentaphylli 14-18, Radix Polygoni Multiflori 10-15.

2. a kind of adjusting blood glucose Chinese medicinal tablet according to claim 1, it is characterized in that, by the raw material of following weight portion, made: Semen Cassiae 20, Rhizoma Polygonati 15, Folium Lycii 12, Fructus Crataegi 10, Radix Notoginseng 8, Radix Puerariae 13, Folium Mori 8, Largeleaf Gymnema 12, Rhizoma Dioscoreae 10, Poria 14, Folium Chrysanthemi 18, the Radix Astragali 15, Fructus Gardeniae 18, Rhizoma Coptidis 10, Radix Salviae Miltiorrhizae 7, cattle are more careless 10, Radix Rehmanniae 8, the Rhizoma Anemarrhenae 16, Chinese toona flower 10, Rhizoma Polygonati Odorati 8, Herba Agrimoniae 10, Fructus Hordei Germinatus 8, Rhizoma Alismatis 10, Radix Platycodonis 12, Herb Gynostemmae Pentaphylli 16, Radix Polygoni Multiflori 15.

3. a preparation method for adjusting blood glucose Chinese medicinal tablet as claimed in claim 1 or 2, is characterized in that comprising the following steps:

(1) depend on pine torch, Folium Lycii, Rhizoma Dioscoreae, Poria, the Radix Astragali, Rhizoma Polygonati Odorati, Herba Agrimoniae, Fructus Hordei Germinatus, Radix Platycodonis, Herb Gynostemmae Pentaphylli mix homogeneously, add 4-6 times of water gaging, decoct and extract 1-2h, filter, filtering residue adds 3-5 times of water gaging again, decocts and extracts 0.5-1h, filter, merging filtrate, standby;

(2) Chinese crude drug mix homogeneously under remainder, adds 5-8 doubly to measure 95% ethanol, reflux, extract, 2-3h, and standing over night, filters, and filtering residue adds 4-6 and doubly measures 80% ethanol, reflux, extract, 1-2h, standing over night, filters, and merging filtrate is standby;

(3) merge the above-mentioned reserve liquid making, standing 12-24h, filters, and filtrate recycling ethanol is also evaporated to the thick paste that relative density is 1.38-1.42, dries, and adds appropriate adjuvant, granulates, dry, and tabletting, coating, gets product.