CN104288501A - Blood glucose reducing particle and preparation method thereof - Google Patents
Blood glucose reducing particle and preparation method thereof Download PDFInfo
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- CN104288501A CN104288501A CN201410593663.9A CN201410593663A CN104288501A CN 104288501 A CN104288501 A CN 104288501A CN 201410593663 A CN201410593663 A CN 201410593663A CN 104288501 A CN104288501 A CN 104288501A
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Abstract
The invention discloses a blood glucose reducing particle and a preparation method thereof. The blood glucose reducing particle is prepared from the following raw material medicines in parts by weight: 200-300 parts of hippophae thamnoides L., 200-300 parts of pueraria lobata, 180-220 parts of polygonatum sibiricum, 130-170 parts of equus asinus L., 130-170 parts of platycodon grandiflorum, 80-120 parts of gardenia jasminoides ellis, 180-220 parts of dioscorea opposita Thunb., 80-120 parts of lycium barbarum L., 180-220 parts of siraitia grosvenorii, 130-170 parts of dry slice of momordica charantia L., 130-170 parts of dry slice of psidium guajava L. and 80-120 parts of leaf of morus alba L.. The blood glucose reducing particle has the efficacy of reducing blood glucose, reducing lipid, promoting the secretion of saliva or body fluid, quenching thirst, enriching yin, nourishing kidney and the like, can obviously improve symptoms of hyperlipemia, polydipsia, diuresis, polyphagia, emaciation, fatigue and lack of strength, deficiency of spleen and stomach and the like together with high blood glucose for patients, and repairs the pancreas islet function. The raw material medicines are all taken from varieties and food with homology of medicine and food, and the blood glucose reducing particle is safe to use.
Description
Technical field
The invention belongs to field of health care food, relate to a kind of hypoglycemic granule and preparation method thereof.
Background technology
Diabetes are a kind of whole body chronic progressive diseases, because beta Cell of islet can not normal secretions insulin, insulin is relatively or definitely not enough, and target cell is to the reduction of insulin sensitivity, and cause sugar, albumen, fat and water and electrolyte metabolism disorderly, hepatic glycogen and muscle glycogen can not be synthesized.Clinical manifestation is that blood glucose raises, glucose in urine is positive and carbohydrate tolerance reduces, and classical symptom is " three-many-one-little ", i.e. polydipsia, polyuria, polyphagia and lose weight.Along with the course of disease extends, easy concurrent whole body nerve, trunk, microangiopathies, and the chronic progressive external pathological changes of the histoorgans such as the heart, brain, kidney, nerve and eye can be caused, many complication increase increasingly, degree increases the weight of, and is the endocrine metabolism disease of serious harm patient health and life.Diabetes are one of universally acknowledged four large pertinacious diseases, and heal with refractory, relapse rate is high, take medicine all the life, complication is many, case fatality rate high and annoying extensive patients.Modern medicine is to the treatment of diabetes mainly glucose-lowering treatment, and namely drug application moves on to liver, muscle sugar from blood vessel, becomes hepatic glycogen or change fat into be in store.The medicine for the treatment of diabetes has (1) insulin; (2) orally-taken blood sugar reducing medicine-sulphanylureas and biguanide derivative; (3) Chinese herbal medicine etc.Chinese medicine and active ingredient of Chinese herbs have stable curative effect, toxicity is little, untoward reaction is few and can the feature of life-time service, day by day cause the attention of people in the preventing and treating of diabetes and complication thereof.
The present invention is especially for diabetics, work out one hypoglycemic granule safely and effectively, be made up of 12 taste Chinese herbal medicine, wherein Fructus Hippophae, Radix Puerariae, Rhizoma Polygonati, Colla Corii Asini, Radix Platycodonis, Fructus Gardeniae, Rhizoma Dioscoreae, Fructus Lycii, Fructus Momordicae, Folium Mori are be food and drug list in " notice about further specification healthy food material management " of Ministry of Public Health announcement in 2002, Fructus Momordicae charantiae is normal edible vegetable, Fructus psidii guajavae immaturus is normal edible fruits, said preparation has the two-way function of nutrition and treatment concurrently, at present, there is not yet relevant report.
(1) Fructus Hippophae is the dry mature fruit of Elaeangnaceae plant Fructus Hippophae Hippophae thamnoides L.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] acid, puckery, and temperature, returns spleen, stomach, lung, heart channel; [function with cure mainly] strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, promoting blood circulation to remove blood stasis.For insufficiency of the spleen lack of appetite, abdominal pain due to retention of food, cough with copious phlegm, obstruction of qi in the chest and cardialgia, blood stasis amenorrhea, falls and flutters stasis of blood arsine.
(2) Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) ohwi." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, pungent, cool, return spleen, stomach, lung meridian; [function with cure mainly] expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
(3) Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum coll.et Hemsl., Rhizoma Polygonati Polygonatum sibirifum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, flat, return spleen, lung, kidney channel; [function with cure mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat is quenched one's thirst.
(4) Colla Corii Asini, for the dry skin of equine species donkey Equus asinus L. or Cortex Dictamni through decocting, the concentrated solid gum made." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, flat, return lung, liver, kidney channel; [function with cure mainly] YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
(5) Radix Platycodonis is the dry root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.Dc.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are bitter, pungent, flat, return lung meridian; [function with cure mainly] lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
(6) Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are bitter, cold, GUIXIN, lung, tri-jiao channel; [function with cure mainly] pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Externally used detumescence pain relieving.Vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
(7) Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, flat, return spleen, lung, kidney channel; [function with cure mainly] spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
(8) Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, flat, return liver, kidney channel; [function with cure mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Fructus Lycii is be food in Ministry of Public Health 2002 " notice about further specification healthy food material management " announced and one of drug list.
(9) Fructus Momordicae is the dry fruit of cucurbitaceous plant Fructus Momordicae Siraiti grosvenorii (Swin gle) C.Jeffrey ex A.M.Lu et Z.Y.Zhang." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, cool.Return lung, large intestine channel; [function with cure mainly] clearing heat and moistening lung, relieving sore throat to recover voice, laxation relieving constipation.For lung-heat type cough, pharyngalgia aphonia, dryness of the intestine constipation.
(10) Fructus Momordicae charantiae dry tablet, be the fruit of cucurbitaceous plant Fructus Momordicae charantiae Momordica charantia L., section is dried." China book on Chinese herbal medicine " records: [nature and flavor with return through] bitter in the mouth, cold in nature, GUIXIN, spleen, lung meridian; [function with cure mainly] clearing away summer-heat washs heat; Improving eyesight; Removing toxic substances.Main summer-heat excessive thirst; Quench one's thirst; Acute conjunctivitis pain; Dysentery; Sore and toxic.
(11) Fructus psidii guajavae immaturus dry tablet, be the fruit of Myrtaceae Psidium plant Fructus psidii guajavae immaturus Psidium guajava L., section is dried." national Chinese herbal medicine compilation " is recorded: [nature and flavor] are sweet, puckery, flat; [function with cure mainly] astringing to arrest diarrhea, anti-inflammation hemostasia.
(12) Folium Mori are the dried leaves of moraceae plants Mulberry Morus alba L.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, bitter, cold, return lung, Liver Channel; [function with cure mainly] dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Summary of the invention
The object of the invention is, for hyperglycemia and complication patient, to provide a kind of hypoglycemic granule and preparation method thereof.
The present inventor selects suitable raw material from " integration of edible and medicinal herbs " class Chinese medicine and food, pass through reasonable preparation, make a kind of hypoglycemic granule, contain the nutrient substance and disease therapy that enrich and the effective ingredient improving health, mouthfeel is good, there is the effects such as hypoglycemic, promoting the production of body fluid to quench thirst, enriching yin and nourishing kidney, can obviously improve hyperglycemia with hyperlipidemia, polydipsia, polyuria, polyphagia, become thin, fatigue and lack of strength, the symptom such as weakness of the spleen and stomach patient, repair islet function, the nutrition of needed by human body can also be supplemented simultaneously.
The technical solution adopted in the present invention is as follows:
A kind of hypoglycemic granule, be made up of the crude drug of following weight part ratio: Fructus Hippophae 200-300 part, Radix Puerariae 200-300 part, Rhizoma Polygonati 180-220 part, Colla Corii Asini 130-170 part, Radix Platycodonis 130-170 part, Fructus Gardeniae 80-120 part, Rhizoma Dioscoreae 180-220 part, Fructus Lycii 80-120 part, Fructus Momordicae 180-220 part, Fructus Momordicae charantiae dry tablet 130-170 part, Fructus psidii guajavae immaturus dry tablet 130-170 part, Folium Mori 80-120 part, the granule adjuvant adding permission in production is prepared from.
Above-described hypoglycemic granule, is preferably made up of the crude drug of following weight part ratio: Fructus Hippophae 250 parts, Radix Puerariae 250 parts, Rhizoma Polygonati 200 parts, 150 parts, Colla Corii Asini, Radix Platycodonis 150 parts, Fructus Gardeniae 100 parts, Rhizoma Dioscoreae 200 parts, Fructus Lycii 100 parts, Fructus Momordicae 200 parts, Fructus Momordicae charantiae dry tablet 150 parts, Fructus psidii guajavae immaturus dry tablet 150 parts, 100 parts, Folium Mori.
The preparation method of the above hypoglycemic granule, comprises the following steps:
1. take Fructus Hippophae, Radix Puerariae, Rhizoma Polygonati, Colla Corii Asini, Radix Platycodonis, Fructus Gardeniae, Rhizoma Dioscoreae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori by weight respectively;
2. Colla Corii Asini is ground into 80-100 object fine powder, for subsequent use;
3. get Rhizoma Dioscoreae, be crushed to 80-100 order, add 6-8 times of water gaging, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, are ground into 80-100 object fine powder, for subsequent use;
4. get Radix Puerariae, be ground into coarse powder, add the ethanol 6-8 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, reclaim ethanol, obtain Radix Puerariae extracting solution;
5. get Fructus Hippophae, Rhizoma Polygonati, Radix Platycodonis, Fructus Gardeniae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori, add water 8-10 times amount, heating extraction 3 times, 2 hours first times, all the other 1 hour/time, filter, merging filtrate, add the Radix Puerariae extracting solution that step 4 obtains, being concentrated into 60 DEG C of relative densities is the clear paste of 1.10-1.30, adds maltodextrin, soluble starch, mixing, granulate, dry, obtain compound particles;
6. in compound particles, add the Rhizoma Dioscoreae powder obtained in the Colla Corii Asini powder and step 3 obtained in step 2, mixing, subpackage, to obtain final product.
Preparation method of the present invention is through that screening and optimizing obtains, and screening and optimizing process is mainly divided into extraction process and preparation process, and main screening situation is as follows:
The extraction process of Radix Puerariae: puerarin is the principle active component of Radix Puerariae, there is blood sugar lowering, improve insulin, blood fat reducing, the effect such as expansion blood vessel.In test with puerarin and preparation melting for inspection target, pulverizing medicinal materials granularity, Extraction solvent (water, 30% ethanol, 50% ethanol, 75% ethanol), quantity of solvent, extraction time, extraction time are screened, result of the test shows: get Radix Puerariae coarse powder, add the ethanol 6-8 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, the puerarin content obtained was higher, and granule melting is good.
The extraction process of Rhizoma Dioscoreae: the polysaccharide such as Rhizoma Dioscoreae is starch-containing, mucus protein, mucus protein has hypoglycemic activity.Be inspection target with mucus protein in test, pulverizing medicinal materials granularity, quantity of solvent, Extracting temperature, extraction time, extraction time are screened, result of the test shows: Rhizoma Dioscoreae powder is broken to 80-100 order, adds 6-8 times of water gaging, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, the mucus protein content obtained is the highest.
All the other constituents extraction techniques: all the other flavour of a drug of the present invention adopt water extraction, to amount of water in test, extraction time, time etc. screen, result shows, and " add water 8-10 times amount, heating extraction 3 times, 2 hours first times; all the other 1 hour/time " is best, be below the investigation to amount of water of the present invention, with n-butyl alcohol extractum for performance assessment criteria, refer to table 1:
Table 1
Extracting solution is concentrated, granulating process: with puerarin recovery rate and melting for performance assessment criteria, determine medical material aqueous extract method for concentration, clear paste relative density, add the composition of adjuvant (compared for starch, soluble starch, dextrin, maltodextrin, lactose), result of the test shows: " being concentrated into 60 DEG C of relative densities is the clear paste of 1.10-1.30; add maltodextrin, soluble starch; mixing; granulate; dry ", and Colla Corii Asini, Rhizoma Dioscoreae extract not add wet granulation effect best; The adjuvant used in production process is less, and granule is many containing crude drug amount, and dose reduces, and grain graininess is even, and in water, melting is better, and can dissolve completely in 3 minutes, the transparent clarification of solution, does not have breeze and deposited phenomenon.
The invention has the beneficial effects as follows:
(1) crude drug all takes from " integration of edible and medicinal herbs " kind and edible vegetable fruit, and use safety can long-term taking.
(2) scientific formulation of the present invention, there is the effects such as hypoglycemic, promoting the production of body fluid to quench thirst, enriching yin and nourishing kidney, can obviously improve hyperglycemia with hyperlipidemia, polydipsia, polyuria, polyphagia, become thin, fatigue and lack of strength, weakness of the spleen and stomach patient symptom, repair islet function, the nutrition of needed by human body can also be supplemented simultaneously.
(3) containing abundant nutrient substance and improve health and disease therapy effective ingredient, have Fructus Momordicae in side, mouthfeel is good, and not containing sucrose, also do not need to add sweeting agent, applicable diabetics is taken, and can also supplement the nutrition of needed by human body.
(4) granule of the present invention, according to each raw material the effective elements of the medicine, adopt modern advanced technologies to be prepared from, method for extraction and purification science, good stability, adjuvant is few, and dose is few, absorbs fast; Not easily moisture absorption is made moist, and boiled water is taken after mixing it with water, and granule is soluble, and the transparent clarification of solution, does not have breeze and deposited phenomenon.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
One, the preparation of hypoglycemic granule
Embodiment 1
The preparation method of hypoglycemic granule, comprises the following steps:
1. take Fructus Hippophae 25kg, Radix Puerariae 25kg, Rhizoma Polygonati 20kg, Colla Corii Asini 15kg, Radix Platycodonis 15kg, Fructus Gardeniae 10kg, Rhizoma Dioscoreae 20kg, Fructus Lycii 10kg, Fructus Momordicae 20kg, Fructus Momordicae charantiae dry tablet 15kg, Fructus psidii guajavae immaturus dry tablet 15kg, Folium Mori 10kg respectively;
2. Colla Corii Asini is ground into 80 object fine powders, for subsequent use;
3. get Rhizoma Dioscoreae, be crushed to 100 orders, add 7 times of water gagings, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, are ground into 100 object fine powders, for subsequent use;
4. get Radix Puerariae, be ground into coarse powder, add ethanol 8 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, reclaim ethanol, obtain Radix Puerariae extracting solution;
5. get Fructus Hippophae, Rhizoma Polygonati, Radix Platycodonis, Fructus Gardeniae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori, add water 8 times amount, heating extraction 3 times, 2 hours first times, all the other 1 hour/time, filter, merging filtrate, add the Radix Puerariae extracting solution that step 4 obtains, being concentrated into 60 DEG C of relative densities is the clear paste of 1.26, adds maltodextrin, soluble starch, mixing, granulate, dry, obtain compound particles;
6. in compound particles, add the Rhizoma Dioscoreae powder obtained in the Colla Corii Asini powder and step 3 obtained in step 2, mixing, subpackage, to obtain final product.
Embodiment 2
The preparation method of hypoglycemic granule, comprises the following steps:
1. take Fructus Hippophae 20kg, Radix Puerariae 20kg, Rhizoma Polygonati 18kg, Colla Corii Asini 13kg, Radix Platycodonis 13kg, Fructus Gardeniae 8kg, Rhizoma Dioscoreae 18kg, Fructus Lycii 8kg, Fructus Momordicae 18kg, Fructus Momordicae charantiae dry tablet 13kg, Fructus psidii guajavae immaturus dry tablet 13kg, Folium Mori 8kg respectively;
2. Colla Corii Asini is ground into 100 object fine powders, for subsequent use;
3. get Rhizoma Dioscoreae, be crushed to 80 orders, add 6 times of water gagings, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, are ground into 80 object fine powders, for subsequent use;
4. get Radix Puerariae, be ground into coarse powder, add ethanol 6 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, reclaim ethanol, obtain Radix Puerariae extracting solution;
5. get Fructus Hippophae, Rhizoma Polygonati, Radix Platycodonis, Fructus Gardeniae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori, add water 9 times amount, heating extraction 3 times, 2 hours first times, all the other 1 hour/time, filter, merging filtrate, add the Radix Puerariae extracting solution that step 4 obtains, being concentrated into 60 DEG C of relative densities is the clear paste of 1.12, adds maltodextrin, soluble starch, mixing, granulate, dry, obtain compound particles;
6. in compound particles, add the Rhizoma Dioscoreae powder obtained in the Colla Corii Asini powder and step 3 obtained in step 2, mixing, subpackage, to obtain final product.
Embodiment 3
The preparation method of hypoglycemic granule, comprises the following steps:
1. take Fructus Hippophae 30kg, Radix Puerariae 30kg, Rhizoma Polygonati 22kg, Colla Corii Asini 17kg, Radix Platycodonis 17kg, Fructus Gardeniae 12kg, Rhizoma Dioscoreae 22kg, Fructus Lycii 12kg, Fructus Momordicae 22kg, Fructus Momordicae charantiae dry tablet 17kg, Fructus psidii guajavae immaturus dry tablet 17kg, Folium Mori 12kg respectively;
2. Colla Corii Asini is ground into 100 object fine powders, for subsequent use;
3. get Rhizoma Dioscoreae, be crushed to 100 orders, add 8 times of water gagings, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, are ground into 80 object fine powders, for subsequent use;
4. get Radix Puerariae, be ground into coarse powder, add ethanol 7 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, reclaim ethanol, obtain Radix Puerariae extracting solution;
5. get Fructus Hippophae, Rhizoma Polygonati, Radix Platycodonis, Fructus Gardeniae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori, add water 10 times amount, heating extraction 3 times, 2 hours first times, all the other 1 hour/time, filter, merging filtrate, add the Radix Puerariae extracting solution that step 4 obtains, being concentrated into 60 DEG C of relative densities is the clear paste of 1.30, adds maltodextrin, soluble starch, mixing, granulate, dry, obtain compound particles;
6. in compound particles, add the Rhizoma Dioscoreae powder obtained in the Colla Corii Asini powder and step 3 obtained in step 2, mixing, subpackage, to obtain final product.
Two, embodiment product beta test
The present invention is once for observing 92 routine hyperglycemic patients.By the above-mentioned 3 kinds of embodiment samples prepared, be respectively used to hyperglycemia with hyperlipidemia, polydipsia, polyuria, polyphagia, become thin, fatigue and lack of strength or weakness of the spleen and stomach patient (man 48 example, female 44 example, 53 years old mean age).The results detailed in Table 2.
Table 2 clinical application effect table
| Embodiment | Recovery from illness (%) | Improve (%) | Invalid (%) |
| Embodiment 1 | 82 | 11 | 7 |
| Embodiment 2 | 85 | 10 | 5 |
| Embodiment 3 | 78 | 15 | 7 |
Result shows: adopt hypoglycemic granule of the present invention, use safety, effectively, there is the effects such as hypoglycemic, promoting the production of body fluid to quench thirst, enriching yin and nourishing kidney, can obviously improve hyperglycemia with hyperlipidemia, polydipsia, polyuria, polyphagia, become thin, fatigue and lack of strength, weakness of the spleen and stomach patient symptom, repair islet function, the nutrition of needed by human body can also be supplemented simultaneously.Be below several model case:
Case 1: high ××, female, 55 years old, hyperglycemia companion hyperlipidemia, polydipsia, polyuria, polyphagia, symptom of becoming thin, fasting glucose 15.6mmol/l, after the meal 2 hours blood glucose 28.5mmol/l.Take the embodiment of the present invention 1, each 1 bag (5g/ bag), every day 3 times, serve on 30, blood glucose drops to normal level (5.8mmol/l on an empty stomach, 6.5mmol/l after the meal), blood fat also returns to normal level, and polydipsia, polyuria, polyphagia symptom are eliminated, and diet recovers normal, body weight increases, recovery from illness.
Case 2: Jiang's ××, man, 60 years old, hyperglycemia companion polydipsia, polyuria, polyphagia, become thin, fatigue and lack of strength, fasting glucose 14.3mmol/l, after the meal 2 hours blood glucose 26.2mmol/l.Take the embodiment of the present invention 2, each 1 bag (5g/ bag), every day 3 times, serve on 60, and blood glucose drops to normal level (on an empty stomach 5.8mmol/l, after the meal 6.1mmol/l), and body weight increases, energetic, recovery from illness.
Case 3 a: ××, female, 48 years old, hyperglycemia companion became thin, fatigue and lack of strength, weakness of the spleen and stomach, fasting glucose 12.5mmol/l, after the meal 2 hours blood glucose 23.7mmol/l.Take the embodiment of the present invention 3, each 1 bag (5g/ bag), every day 3 times, serve on 50, and blood glucose drops to normal level (on an empty stomach 5.5mmol/l, after the meal 6.0mmol/l), and appetite increases, and body weight increases, of pink and healthy-looking, energetic, recovery from illness.
Claims (3)
1. a hypoglycemic granule, it is characterized in that, be made up of the crude drug of following weight part ratio: Fructus Hippophae 200-300 part, Radix Puerariae 200-300 part, Rhizoma Polygonati 180-220 part, Colla Corii Asini 130-170 part, Radix Platycodonis 130-170 part, Fructus Gardeniae 80-120 part, Rhizoma Dioscoreae 180-220 part, Fructus Lycii 80-120 part, Fructus Momordicae 180-220 part, Fructus Momordicae charantiae dry tablet 130-170 part, Fructus psidii guajavae immaturus dry tablet 130-170 part, Folium Mori 80-120 part.
2. hypoglycemic granule according to claim 1, it is characterized in that, be made up of the crude drug of following weight part ratio: Fructus Hippophae 250 parts, Radix Puerariae 250 parts, Rhizoma Polygonati 200 parts, 150 parts, Colla Corii Asini, Radix Platycodonis 150 parts, Fructus Gardeniae 100 parts, Rhizoma Dioscoreae 200 parts, Fructus Lycii 100 parts, Fructus Momordicae 200 parts, Fructus Momordicae charantiae dry tablet 150 parts, Fructus psidii guajavae immaturus dry tablet 150 parts, 100 parts, Folium Mori.
3. a preparation method for hypoglycemic granule as claimed in claim 1 or 2, is characterized in that, comprise the following steps:
(1) Fructus Hippophae, Radix Puerariae, Rhizoma Polygonati, Colla Corii Asini, Radix Platycodonis, Fructus Gardeniae, Rhizoma Dioscoreae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori are taken by weight respectively;
(2) Colla Corii Asini is ground into 80-100 object fine powder, for subsequent use;
(3) get Rhizoma Dioscoreae, be crushed to 80-100 order, add 6-8 times of water gaging, 60 DEG C of warm macerating 3 times, each 2 hours, filter, merging filtrate, in 60 DEG C of concentrating under reduced pressure, 60 DEG C of drying under reduced pressure, are ground into 80-100 object fine powder, for subsequent use;
(4) get Radix Puerariae, be ground into coarse powder, add the ethanol 6-8 times amount of 50%, heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, reclaim ethanol, obtain Radix Puerariae extracting solution;
(5) get Fructus Hippophae, Radix Puerariae, Rhizoma Polygonati, Radix Platycodonis, Fructus Gardeniae, Fructus Lycii, Fructus Momordicae, Fructus Momordicae charantiae dry tablet, Fructus psidii guajavae immaturus dry tablet, Folium Mori, add water 8-10 times amount, heating extraction 3 times, 2 hours first times, all the other 1 hour/time, filter, merging filtrate, add the Radix Puerariae extracting solution that step (4) obtains, being concentrated into 60 DEG C of relative densities is the clear paste of 1.10-1.30, adds maltodextrin, soluble starch, mixing, granulate, dry, obtain compound particles;
(6) in compound particles, add the Rhizoma Dioscoreae powder obtained in the Colla Corii Asini powder and step (3) obtained in step (2), mixing, subpackage, to obtain final product.
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105639637A (en) * | 2016-02-01 | 2016-06-08 | 林爱玉 | Health care food with blood sugar reduction function |
| CN105639636A (en) * | 2016-02-01 | 2016-06-08 | 林爱玉 | Health care food with liver protection and blood sugar reduction functions and making method thereof |
| CN105724699A (en) * | 2016-03-31 | 2016-07-06 | 仲恺农业工程学院 | Bitter melon teabag and making method thereof |
| CN105957977A (en) * | 2016-05-13 | 2016-09-21 | 京东方科技集团股份有限公司 | Packaging material, packaging cover plate, sintering device, sintering method and display device |
| CN106035878A (en) * | 2016-07-12 | 2016-10-26 | 张明科 | Medicine and food homology functional tea and preparing method thereof |
| CN106420862A (en) * | 2016-08-03 | 2017-02-22 | 黄海娟 | Tea with effects of clearing heat and removing dampness and preparation method thereof |
| CN106620247A (en) * | 2016-11-25 | 2017-05-10 | 安徽邵氏华艾生物医疗电子科技有限公司 | Traditional Chinese medicine granule for nourishing liver and brightening eye and preparation method of traditional Chinese medicine granule |
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| CN108379428A (en) * | 2018-05-10 | 2018-08-10 | 湖南康尔佳制药股份有限公司 | A kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst |
| CN108743769A (en) * | 2018-05-10 | 2018-11-06 | 湖南康尔佳制药股份有限公司 | A kind of capsule for lowering blood sugar and preventing thirst and preparation method thereof |
| CN109315574A (en) * | 2018-10-12 | 2019-02-12 | 肖文中 | A kind of mulberry leaf balsam pear pressed candy |
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-
2014
- 2014-10-29 CN CN201410593663.9A patent/CN104288501A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| WYGJ2001: "本草糖方", 《甜蜜家园糖尿病论坛》 * |
| 杜红霞等: "辅助降糖保健食品研究现状", 《中国食物与营养》 * |
| 牟洪林: "《中医治疗糖尿病眼病》", 31 October 2013, 天津科技翻译出版有限公司 * |
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