CN108379428A - A kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst - Google Patents

A kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst Download PDF

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Publication number
CN108379428A
CN108379428A CN201810444752.5A CN201810444752A CN108379428A CN 108379428 A CN108379428 A CN 108379428A CN 201810444752 A CN201810444752 A CN 201810444752A CN 108379428 A CN108379428 A CN 108379428A
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crushing chamber
powder
capsule
mixed powder
mixed
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易志红
曾杰
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Hunan Kaang'er Pharmaceutical Ltd By Share Ltd
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Hunan Kaang'er Pharmaceutical Ltd By Share Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

This application discloses a kind of preparation method of capsule for lowering blood sugar and preventing thirst and its system, specific steps:The first mixed powder is obtained using cowpea, balsam pear and Chinese yam;Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine are put into infuser device and impregnated;Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine are added in decocting device and decocted, decoction solution is obtained;Obtain the corresponding residue concentrate of decoction solution;After liquid and the merging of residue concentrate will be decocted, passes through purifying plant and carry out thickening filtration, obtain mixed concentrated liquid;Into mixed concentrated liquid after cooling, ethyl alcohol is added in stirring, obtains mixing condensed cream;Mixing condensed cream is put into the second drying device, the second mixed powder of acquisition is dried;First mixed powder and the second mixed powder are put into the second mixing arrangement to carry out that acquisition mixed powder is mixed evenly;Mixed powder is packed into capsule.By being improved to multiple steps in preparation process, the waste of medicinal material is effectively reduced, the pharmacological property of capsule is improved, reduces blood sugar for human body content.

Description

A kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst
Technical field
This application involves a kind of preparation method of Chinese medicinal capsule and its equipment more particularly to a kind of systems of capsule for lowering blood sugar and preventing thirst Preparation Method and its system.
Background technology
The clinical manifestation of diabetic is more foods, more drinks, diuresis and becomes thin, and becomes diabetes.Diabetes patient is due to more Urine, is susceptible to water shortage situation.In especially summer, ambient temperature is higher, and human body is easy to perspire, in addition diabetes patient's diuresis, more It is easy to cause patient's water shortage.Diabetes patient's water shortage be easy to cause pachyemia and blood viscosity increases, and such as supplements water not in time Point, it is easy to aggravate patient's state of an illness.In order to mitigate the diabetes of diabetes patient, generally require to take capsule for lowering blood sugar and preventing thirst.
The preparation method of existing capsule for lowering blood sugar and preventing thirst is directly to add water to decoct medicinal material, and carried out to decoction solution Directly purification obtains capsule for lowering blood sugar and preventing thirst.Due to preparation method incomplete so that the capsule pharmacological property prepared based on the medicinal material not Completely, best in order to make the pharmacological property of medicinal material perform to, it is proposed that a kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst.
Invention content
This application provides a kind of preparation method of capsule for lowering blood sugar and preventing thirst and its systems, are prepared with solving existing preparation method The incomplete technical problem of capsule pharmacological property.
In order to solve the above-mentioned technical problem, this application discloses following scheme:
This application provides a kind of preparation methods of capsule for lowering blood sugar and preventing thirst, include the following steps:
S01:The first mixed powder is obtained using cowpea, balsam pear and Chinese yam;
S02:Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine after cleaning are put into infuser device and impregnated;
S03:Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine are added in decocting device and decocted, decoction solution is obtained;
S04:Obtain the corresponding residue concentrate of decoction solution;
S06:After liquid and the merging of residue concentrate will be decocted, pass through purifying plant and carry out thickening filtration, obtains mixing and concentrate Liquid;
S07:Into mixed concentrated liquid after cooling, uniform stirring is added 3-5 times and measures ethyl alcohol, stands 18-30h, is mixed Condensed cream;
S08:It mixing condensed cream is put into the second drying device is dried and obtain the second mixed powder, and by the first mixed powder With the second mixed powder be mixed and is put into the second mixing arrangement and carries out that acquisition mixed powder is mixed evenly;
S09:Mixed powder is packed into capsule, you can.
Preferably, the first mixed powder is obtained using cowpea, balsam pear and Chinese yam, including:
Segment is placed in the first drying device dry after cowpea, balsam pear and Chinese yam are cleaned;
Dried cowpea, balsam pear and Chinese yam are respectively put into grinding device and carry out multi-stage crushing, obtains cowpea powder, hardship Melon powder and yam flour;
Cowpea powder, balsam pear powder and yam flour are sequentially placed into the first mixing arrangement and are stirred mixing, it is mixed to obtain first Close powder.
Preferably, the acetic acid of 3-5%, soaking time 20-30min are put into infuser device.
Preferably, decoct number at least once more than, and first decoct water be 12-14 times, time 1-3h;Second The water of decoction is 9-12 times, time 1-3h.
Preferably, obtaining the corresponding residue concentrate of decoction solution includes:
The corresponding residue of solution will be decocted to be put into agitating device, and cellulase and pectin are added into agitating device Enzyme;
Residue solution after enzymolysis is heated to 90 DEG C of progress enzyme deactivations;
After residue solution after enzyme deactivation is stirred evenly, the extracting solution for obtaining residue solution is filtered by filter;
The extracting solution of residue solution is obtained into residue concentrate through repeatedly centrifugation purification.
Present invention also provides a kind of preparation system of capsule for lowering blood sugar and preventing thirst, system including the first powder prepare subsystem, Second powder prepares subsystem and the second mixing arrangement, wherein
It includes the first drying device, grinding device and the first mixing arrangement, the first mixing dress that first powder, which prepares subsystem, It sets and is connect with the second mixing arrangement;
It includes infuser device, decocting device, agitating device, purifying plant and the second drying dress that second powder, which prepares subsystem, It sets, the second drying device is connect with the second mixing arrangement, and decocting device is set between infuser device and purifying plant, dress of boiling medicine Connection agitating device is set, agitating device connects purifying plant, and the second drying device is set to purifying plant and the second mixing arrangement Between;
Grinding device is set between the first drying device and the first mixing arrangement, and grinding device is provided with the first crushing chamber With the second crushing chamber, the first crushing chamber is provided with first charging aperture, second charging aperture and discharge port, and the first crushing chamber is provided with One end of one feed inlet is the top of the first crushing chamber, and one end that the first crushing chamber is provided with discharge port is the bottom of the first crushing chamber Portion is both provided with crushed piece in the first crushing chamber, and crushed piece includes connecting rod and shredder head, and one end of connecting rod passes through spring part The top of the first crushing chamber is connected, the other end of connecting rod connects shredder head, and shredder head is solid iron ball, the both sides pair of connecting rod Title is provided with sawtooth;
Each component for being internally provided with the first crushing chamber identical function of second crushing chamber, the bottom setting of the first crushing chamber There are the first filter screen, discharge port to be connect by connecting tube with the first charging aperture of the second crushing chamber, connecting tube includes the first connection Pipe and the second connecting tube, connecting hole is provided on the side wall of the first connecting tube, and connecting hole connects the first connecting tube and connect with second Pipe, the first connecting tube are connect with the first charging aperture of the second crushing chamber, the second charging aperture of the second connecting tube and the first crushing chamber Connection, the second connecting tube is provided with close to one end of the second charging aperture of the first crushing chamber inhales grain machine, and the first connecting tube is close to even It connects and is provided with the second filter screen on the downside of hole, the pore size filter of the first filter screen is more than the pore size filter of the second filter screen.
Preferably, the gap setting of sawtooth has stirring parts, side of the stirring parts far from connecting rod to be provided with stirring-head, stirring The blade of different angle is provided on head;
Preferably, grinding device is additionally provided with third crushing chamber, and the inside of the second crushing chamber and third crushing chamber is respectively provided with There are crushed piece identical with the first crushing chamber function and filter screen, and in third crushing chamber, the second crushing chamber and the first crushing chamber The crushed piece in portion and the size of filter screen are reduced successively.
The advantageous effect of the application:
This application provides a kind of preparation methods of capsule for lowering blood sugar and preventing thirst, first, the are obtained using cowpea, balsam pear and Chinese yam One mixed powder;Secondly, Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine after cleaning are put into infuser device and are impregnated, and be added It is decocted in decocting device, obtains decoction solution;Again, the residue concentrate of the decoction liquid of acquisition and acquisition is merged concentrated Filter obtains mixed concentrated liquid;Then, mixed concentrated liquid is prepared into condensed cream, and condensed cream is dried and obtains the second mixed powder; Finally, the first mixed powder and the second mixed powder are mixed to get mixed powder, and are packed into capsule.By cowpea, balsam pear and Chinese yam etc. The vegetable drying that blood sugar for human body content can be reduced grinds the first mixed powder of acquisition, can not only retain and be conducive to drop in vegetables The substance of blood glucose can also retain other nutriments in vegetables, effectively improve the consumption and nutritive value of capsule.It is right It puts it into infuser device and is soaked for a period of time first in chinese medicine material, then it is carried out plus is decocted in water for oral dose.Medicinal material directly passes through Add and be decocted in water for oral dose so that being difficult to be dissolved in the water in utility section time in medicinal material so that traditional decoction method cannot be by medicine The utility of material all releases, and influences the pharmacological property of capsule.Also contain in medicinal material residue after adding and being decocted in water for oral dose useful The enzyme dissolving purification of residue is obtained residue concentrate by substance in order to further increase the pharmacological property of single capsule.By the residual of acquisition Slag concentrate and the mixing of decoction solution and thickening filtration acquisition mixed concentrated liquid.The cell wall that residue is destroyed with enzyme, makes in residue Utility all release so that the single capsule pharmacological property of preparation further increases, so mitigate diabetes patient blood Sugared content.Mixed concentrated liquid is prepared into condensed cream again, and condensed cream is dried into the second mixed powder of acquisition and is finally mixed first It closes powder and the second mixed powder is mixed to get mixed powder, and be packed into capsule.The application passes through to multiple steps in preparation process It is improved, effectively reduces the waste of medicinal material, improve the pharmacological property of single capsule, and then the blood glucose for reducing diabetes patient contains Amount.
Description of the drawings
In order to illustrate more clearly of the technical solution of the application, letter will be made to attached drawing needed in the embodiment below Singly introduce, it should be apparent that, for those of ordinary skills, without creative efforts, also It can be obtain other attached drawings according to these attached drawings.
Fig. 1 is a kind of method flow diagram of the preparation method of capsule for lowering blood sugar and preventing thirst provided by the embodiments of the present application;
Fig. 2 is a kind of schematic diagram of the preparation system of capsule for lowering blood sugar and preventing thirst provided by the embodiments of the present application;
Fig. 3 is a kind of schematic diagram of grinding device provided by the embodiments of the present application;
Fig. 4 is a kind of schematic diagram of crushed piece provided by the embodiments of the present application;
Description of the drawings:The first drying devices of 1-, 2- grinding devices, the first mixing arrangements of 3-, 4- infuser devices, 5- boil medicine dress It sets, 6- agitating devices, 7- purifying plants, the second drying devices of 8-, the second mixing arrangements of 9-, the first crushing chambers of 21-, 22- second Crushing chamber, 23- third crushing chambers, 24- connecting tubes, 211- first charging apertures, 212- second charging apertures, 213- discharge ports, 214- Crushed piece, the first filter screens of 215-, the first connecting tubes of 241-, the second connecting tubes of 242-, 2141- connecting rods, 2142- shredder heads, 2143- stirring parts, 2411- connecting holes, the second filter screens of 2412-, 2421- inhale grain machine, 21431- stirring-heads.
Specific implementation mode
In order to make those skilled in the art better understand the technical solutions in the application, below in conjunction with the application reality The attached drawing in example is applied, technical solutions in the embodiments of the present application is clearly and completely described, it is clear that described implementation Example is only some embodiments of the present application, rather than whole embodiments.Based on the embodiment in the application, the common skill in this field The every other embodiment that art personnel are obtained without making creative work should all belong to the application protection Range.
It is a kind of method flow diagram of the preparation method of capsule for lowering blood sugar and preventing thirst provided by the embodiments of the present application referring to Fig. 1.This Application provides a kind of preparation method of capsule for lowering blood sugar and preventing thirst, includes the following steps:
S01:The first mixed powder is obtained using cowpea, balsam pear and Chinese yam;
Segment is placed in the first drying device dry after cowpea, balsam pear and Chinese yam are cleaned;By dried cowpea, balsam pear It is respectively put into grinding device with Chinese yam and carries out multi-stage crushing, obtain cowpea powder, balsam pear powder and yam flour;By cowpea powder, balsam pear Powder and yam flour, which are sequentially placed into the first mixing arrangement, is stirred mixing, obtains the first mixed powder.
Vegetables after segment can not only efficiently reduce drying time, can also be effectively reduced when carrying out multi-stage crushing Grinding time, and then improve the crush efficiency of vegetables.Grinding device is provided with multi-stage crushing chamber, when can efficiently reduce crushing Between so that the material mixing after crushing is also more uniformly distributed.
S02:Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine after cleaning are put into infuser device and impregnated;
It is put into the acetic acid of 3-5% in infuser device, the acetic acid immersion of soaking time 20-30min, 3-5% can make kind The useful component of the substances such as pomegranate leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine quickly can comprehensively be dissolved in the water, and be effectively improved The utilization rate and working efficiency of medicinal material.
S03:Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine are added in decocting device and decocted, decoction solution is obtained;
Decoct number at least once more than, and first decoct water be 12-14 times, time 1-3h;Second decoction Water is 9-12 times, time 1-3h.Decocting twice can make the utility of medicinal material more fully be dissolved in the water, into one Step reduces the waste of medicinal material, improves the pharmacological property of single capsule.
S04:Obtain the corresponding residue concentrate of decoction solution;
The corresponding residue of solution will be decocted to be put into agitating device, and cellulase and pectin are added into agitating device Enzyme;
Residue solution after enzymolysis is heated to 90 DEG C of progress enzyme deactivations;
After residue solution after enzyme deactivation is stirred evenly, the extracting solution for obtaining residue solution is filtered by filter;
The extracting solution of residue solution is obtained into residue concentrate through repeatedly centrifugation purification.
By being simply decocted in water for oral dose, the utility in medicinal material cannot completely dissolve in water.In order to make the drug effect of medicinal material Reach best, the corresponding residue of the second decoction solution is digested, the utility in residue is molten by the cell wall of destruction In solution, solution is subjected to purification, residue concentrate is obtained by filtration.The substances such as the Quercetin contained in residue concentrate can be with It is effectively reduced blood sugar for human body content, and then mitigates the diabetes of diabetes patient.
S05:After liquid and the merging of residue concentrate will be decocted, pass through purifying plant and carry out thickening filtration, obtains mixing and concentrate Liquid;
S06:Into mixed concentrated liquid after cooling, uniform stirring is added 3-5 times and measures ethyl alcohol, stands 18-30h, is mixed Condensed cream;
S07:Mixing condensed cream is put into the second drying device, the second mixed powder of acquisition is dried;
S08:First mixed powder and the second mixed powder, which be mixed, to be put into the second mixing arrangement and be mixed Even acquisition mixed powder;
First mixed powder and the second mixed powder carry out heating stirring, rotating speed 1500r/min, temperature in the second mixing arrangement Degree is 50 degree.50 degree of temperature is not easy that the first mixed powder and the second mixed powder activity is made to inactivate, and can reduce in mixed powder Moisture, effectively improve the shelf-life of medicament.
S09:Mixed powder is packed into capsule, you can.
The vegetable drying that cowpea, balsam pear and Chinese yam etc. can be reduced to blood sugar for human body content grinds the first mixed powder of acquisition, It can not only retain in vegetables and be conducive to hypoglycemic substance, other nutriments in vegetables can also be retained, effectively Improve the consumption and nutritive value of capsule.Chinese medicine material is put it into infuser device first and is soaked for a period of time, then It is carried out plus is decocted in water for oral dose.Medicinal material is directly decocted in water for oral dose by adding so that being difficult to be dissolved in water in utility section time in medicinal material In so that traditional decoction method cannot all release the utility of medicinal material, influence the pharmacological property of capsule.By adding water Also contain utility in medicinal material residue after decoction, in order to further increase the pharmacological property of single capsule, by the enzyme dissolving of residue Purification obtains residue concentrate.The residue concentrate of acquisition and decoction solution are mixed and thickening filtration obtains mixed concentrated liquid. With enzyme destroy residue cell wall, so that the utility in residue is all released so that the single capsule pharmacological property of preparation into One step improves, and then mitigates the blood-sugar content of diabetes patient.Mixed concentrated liquid is prepared into condensed cream again, and condensed cream is dried The second mixed powder is obtained, finally, the first mixed powder and the second mixed powder are mixed to get mixed powder, and be packed into capsule.This Shen Please by being improved to multiple steps in preparation process, the waste of medicinal material is effectively reduced, the medicine of single capsule is improved Property, and then mitigate the blood-sugar content of diabetes patient.
It is provided by the embodiments of the present application that present invention also provides a kind of preparation systems of capsule for lowering blood sugar and preventing thirst referring to Fig. 2 A kind of schematic diagram of the preparation system of capsule for lowering blood sugar and preventing thirst.The preparation system prepares subsystem, the second powder including the first powder Prepare subsystem and the second mixing arrangement 9, wherein it includes the first drying device 1, grinding device 2 that the first powder, which prepares subsystem, With the first mixing arrangement 3, grinding device 2 is set between the first drying device 1 and the first mixing arrangement 3, the first mixing arrangement 3 It is connect with the second mixing arrangement 9;It includes infuser device 4, decocting device 5, agitating device 6, purification that second powder, which prepares subsystem, Device 7 and the second drying device 8, the second drying device 8 are connect with the second mixing arrangement 9, and decocting device 5 is set to infuser device Between 4 and purifying plant 7, decocting device 5 connects agitating device 6, and agitating device 6 connects purifying plant 7, the second drying device 8 It is set between purifying plant 7 and the second mixing arrangement 9.
In order to improve working efficiency, in the preparation process of capsule, the preparation of the first mixed powder and the second mixed powder simultaneously into Row.Preparation for the first mixed powder is put into drying device 1 after first cleaning cowpea, balsam pear and Chinese yam and is dried, then Dried cowpea, balsam pear and Chinese yam are added sequentially to crush in grinding device 2, then by cowpea powder, the balsam pear powder after crushing It is added sequentially to carry out being mixed in the first mixing arrangement 3 with yam flour to obtain the first mixed powder.For the second mixed powder It prepares, Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine after cleaning is put into infuser device 4 and are soaked for a period of time, will be impregnated Substance be put into decocting device and decocted, then the decoction solution after decocting takes out, and is placed in purifying plant 7, and after decocting The merging 6 enzyme stirring of agitating device of medicinal material residue after take supernatant to be placed in purifying plant 7 to mix and purify, after purification Medicinal material adds ethyl alcohol to carry out livering to it, and the medicinal material after livering is placed in the second drying device 8 and is dried to obtain the second mixed powder, The second mixed powder after drying is placed in be mixed in the second mixing arrangement 9 and obtains mixed powder.
It is a kind of schematic diagram of grinding device provided by the embodiments of the present application referring to Fig. 3.In order to make cowpea, balsam pear and mountain Powder after the grates vegetables such as medicine is more tiny, and grinding device 2 is provided with the first crushing chamber 21 and the second crushing chamber 22.First Crushing chamber 21 is provided with first charging aperture 211, second charging aperture 212 and discharge port 213, the first crushing chamber 21 be provided with first into One end of material mouth 211 is the top of the first crushing chamber 21, and one end that the first crushing chamber 21 is provided with discharge port 213 is the first crushing The bottom of chamber 21.It is crushed due to difficult after the vegetable dryings such as cowpea, crushing is forced to be easily destroyed the first crushing chamber 21.In order to reduce powder Damage, crushed piece 214, powder are both provided in the first crushing chamber 21 caused by the first crushing chamber of the hard materials pair such as broken cowpea 21 Aster 214 includes connecting rod 2141 and shredder head 2142, and one end of connecting rod 2141 connects the first crushing chamber 21 by spring part Top, the other end of connecting rod 2141 connects shredder head 2142, and shredder head 2142 is solid metal ball, the two of connecting rod 2141 Side is symmetrically arranged with sawtooth.During use, solid metal ball under gravity, as spring part is up and down.It is solid The up and down of metal ball can scrap the hard vegetables such as cowpea in advance as the milling of larger particles.Due to the work of spring part With crushed piece 214 not only can be up and down, may also function as activity, and under the effect of spring part elastic force, solid metal ball is into one Walk comminuted powder.Since the both sides of connecting rod 2141 are symmetrically arranged with sawtooth, under the rotation of connecting rod 2141, powder can lead to It is smaller size of powder to cross sawtooth and further crush.
In order to make the smaller of powder, the second crushing chamber 22 be internally provided with each of 21 identical function of the first crushing chamber The bottom of component, the first crushing chamber 21 is provided with the first filter screen 215.By 21 powder pulverized powder of the first filter chamber, first Under the action of filter screen 215, filtered powder is exported by discharge port 213.Due to discharge port 213 and the second crushing chamber 22 first charging aperture is connected by connecting tube 24, connecting tube 24 include the first connecting tube 241 and the second connecting tube 242, first Connecting hole 2411 is provided on the side wall of connecting tube 241, connecting hole 2411 connects the first connecting tube 241 and the second connecting tube 242, Second connecting tube 242 is connect with the second charging aperture 212 of the first crushing chamber 21.Due to solid metal ball be with spring can more than Lower bounce so that be slightly larger than the pore size filter of the first filter screen 215, powder by the size of certain powder of the first filter screen 215 The size at end not only be easy to cause greatly the blocking of connecting tube 24, also causes difficulty to the crushing of next step.In order to make powder even The circulation of take over 24 is more smoothly, and the first connecting tube 241 is connect with the first charging aperture of the second crushing chamber 22, the second connecting tube 242 are provided with suction grain machine 2421 close to one end of the second charging aperture 212 of the first crushing chamber 21.First connecting tube 241 is close to even The downside for connecing hole 2411 is provided with the second filter screen 2412, and the pore size filter of the first filter screen 215 is greater than or equal to the second filtering The pore size filter of net 2412.During use, when particle size is less than the pore size filter of the second filter screen 2412, particle is direct It is filtered, and is transferred in the second crushing chamber 22 by the second filter screen 2412 of the first connecting tube 241.When the size of certain particles More than the second filter screen 2412 pore size filter when, can be by these large scales by the suction grain machine 2421 in the second connecting tube 242 Particle is absorbed and is input in the first crushing chamber 21 again through second charging aperture 212 to be crushed again so that is entered second and is crushed The particle size of chamber 22 is small and uniform.Under the collective effect of the first crushing chamber 21 and the second crushing chamber 22, the powder after crushing Also more careful.
It is a kind of schematic diagram of crushed piece provided by the embodiments of the present application referring to Fig. 4.In order to keep the size of powder more thin It is small, in the present embodiment, there are stirring parts 2143, side setting of the stirring parts 2143 far from connecting rod 2141 in the gap setting of sawtooth There is stirring-head 21431, the blade of different angle is provided on stirring-head 21431.Stirring-head 21431 is provided with the knife of different angle The powder of rotation can be further cut into smaller size of particle, further crush powder, reduced multiple crushing by piece Time, improve work efficiency.
Crushing in order to make powder more fully, is additionally provided with third crushing chamber 23, the second crushing chamber in grinding device 2 22 and the inside of third crushing chamber 23 be both provided with crushed piece identical with 21 function of the first crushing chamber and filter screen, and third powder The size of crushed piece and filter screen inside broken chamber 23, the second crushing chamber 22 and the first crushing chamber 21 is reduced successively.By successively The crushed piece of reduction and the size of filter screen, can be such that powder crushes more conveniently so that obtain cowpea powder, balsam pear powder and Chinese yam The mixing of powder is more uniformly distributed, and the drug effect of cowpea powder, balsam pear powder and yam flour can also performed to best.
Those skilled in the art will readily occur to its of the application after considering the embodiment of specification and practice here Its embodiment.This application is intended to cover any variations, uses, or adaptations of the application, these modifications, purposes or Person's adaptive change follows the general principle of the application and includes the not used common knowledge in the art of the application Or conventional techniques.The description and examples are only to be considered as illustrative, and the true scope and spirit of the application are by following Claim is pointed out.
It should be understood that the application is not limited to the precision architecture for being described above and being shown in the accompanying drawings, and And various modifications and changes may be made without departing from the scope thereof.Scope of the present application is only limited by the accompanying claims.

Claims (8)

1. a kind of preparation method of capsule for lowering blood sugar and preventing thirst, which is characterized in that include the following steps:
S01:The first mixed powder is obtained using cowpea, balsam pear and Chinese yam;
S02:Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine after cleaning are put into infuser device and impregnated;
S03:The Guava Leaf, STEVIA REBAUDIANA, mulberry leaf and matrimony vine are added in decocting device and decocted, decoction solution is obtained;
S04:Obtain the corresponding residue concentrate of the decoction solution;
S05:After the decoction liquid and the residue concentrate are merged, thickening filtration is carried out by purifying plant, is mixed Concentrate;
S06:Into the mixed concentrated liquid after cooling, uniform stirring is added 3-5 times and measures ethyl alcohol, stands 18-30h, is mixed Condensed cream;
S07:The mixing condensed cream is put into the second drying device, the second mixed powder of acquisition is dried;
S08:First mixed powder and second mixed powder are put into the second mixing arrangement to carry out that acquisition is mixed evenly Mixed powder;
S09:The mixed powder is packed into capsule, you can.
2. the preparation method of capsule for lowering blood sugar and preventing thirst according to claim 1, which is characterized in that described to utilize cowpea, balsam pear The first mixed powder is obtained with Chinese yam, including:
Segment is placed in the first drying device dry after cowpea, balsam pear and Chinese yam are cleaned;
The dried cowpea, the balsam pear and the Chinese yam are respectively put into grinding device and carry out multi-stage crushing, is obtained Cowpea powder, balsam pear powder and yam flour;
The cowpea powder, the balsam pear powder and the yam flour are sequentially placed into the first mixing arrangement and are stirred mixing, is obtained Obtain the first mixed powder.
3. the preparation method of capsule for lowering blood sugar and preventing thirst according to claim 1, which is characterized in that be put into the infuser device The acetic acid of 3-5%, soaking time 20-30min.
4. the preparation method of capsule for lowering blood sugar and preventing thirst according to claim 1, which is characterized in that the decoction number at least one More than secondary, and the first water decocted is 12-14 times, time 1-3h;Second water decocted is 9-12 times, time 1- 3h。
5. the preparation method of capsule for lowering blood sugar and preventing thirst according to claim 1, which is characterized in that the acquisition decocts solution pair The residue concentrate answered includes:
The corresponding residue of the decoction solution is put into agitating device, and cellulase and pectin are added into agitating device Enzyme;
Residue solution after enzymolysis is heated to 90 DEG C of progress enzyme deactivations;
After residue solution after enzyme deactivation is stirred evenly, the extracting solution for obtaining residue solution is filtered by filter;
The extracting solution of residue solution is obtained into residue concentrate through repeatedly centrifugation purification.
6. a kind of preparation system of capsule for lowering blood sugar and preventing thirst, which is characterized in that the system comprises the first powder to prepare subsystem, Two powder prepare subsystem and the second mixing arrangement (9), wherein
It includes the first drying device (1), grinding device (2) and the first mixing arrangement (3), institute that first powder, which prepares subsystem, The first mixing arrangement (3) is stated to connect with second mixing arrangement (9);
It includes infuser device (4), decocting device (5), agitating device (6), purifying plant (7) that second powder, which prepares subsystem, With the second drying device (8), second drying device (8) connect with second mixing arrangement (9), the decocting device (5) it is set between the infuser device (4) and the purifying plant (7), the decocting device (5) connects the agitating device (6), the agitating device (6) connects the purifying plant (7), and second drying device (8) is set to the purifying plant (7) between second mixing arrangement (9);
The grinding device (2) is set between first drying device (1) and first mixing arrangement (3), the powder Crushing device (2) is provided with the first crushing chamber (21) and the second crushing chamber (22), first crushing chamber (21) be provided with first into Material mouth (211), second charging aperture (212) and discharge port (213), first crushing chamber (21) are provided with first charging aperture (211) one end is the top of first crushing chamber (21), and first crushing chamber (21) is provided with the one of discharge port (213) End is the bottom of first crushing chamber (21), and crushed piece (214), the crushing are both provided in first crushing chamber (21) Part (214) includes connecting rod (2141) and shredder head (2142), and one end of the connecting rod (2141) connects institute by spring part The top of the first crushing chamber (21) is stated, the other end of the connecting rod (2141) connects the shredder head (2142), the crushing Head (2142) is solid metal ball, and the both sides of the connecting rod (2141) are symmetrically arranged with sawtooth;
Each component of second crushing chamber (22) being internally provided with the first crushing chamber (21) identical function, described The bottom of one crushing chamber (21) is provided with the first filter screen (215), the discharge port (213) and second crushing chamber (22) First charging aperture is connected by connecting tube (24), and the connecting tube (24) includes the first connecting tube (241) and the second connecting tube (242), connecting hole (2411) is provided on the side wall of first connecting tube (241), described in connecting hole (2411) connection First connecting tube (241) and second connecting tube (242), the of first connecting tube (241) and the second crushing chamber (22) One feed inlet connects, and the second charging aperture (212) of second connecting tube (242) and first crushing chamber (21) connects It connects, second connecting tube (242) is provided with close to one end of the second charging aperture (212) of first crushing chamber (21) Grain machine (2421) is inhaled, first connecting tube (241) is provided with the second filter screen on the downside of the connecting hole (2411) (2412), the pore size filter of first filter screen (215) is more than the pore size filter of second filter screen (2412).
7. preparation system according to claim 6, which is characterized in that the interstitial site of the sawtooth is provided with stirring parts (2143), side of the stirring parts (2143) far from the connecting rod (2141) is provided with stirring-head (21431), the stirring The blade of different angle is provided on head (21431).
8. preparation system according to claim 6, which is characterized in that the grinding device (2) is additionally provided with third crushing The inside of chamber (23), second crushing chamber (22) and the third crushing chamber (23) is additionally provided with and first crushing chamber (21) the identical crushed piece of function and filter screen, and the third crushing chamber (23), second crushing chamber (22) and described The internal crushed piece of one crushing chamber (21) and the size of filter screen are reduced successively.
CN201810444752.5A 2018-05-10 2018-05-10 A kind of preparation method and its system of capsule for lowering blood sugar and preventing thirst Pending CN108379428A (en)

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Application publication date: 20180810