CN107260821A - For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft - Google Patents
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The method that the present invention utilizes three water extractions, effective ingredient in selfheal is concentrated and dried, obtain Prunella vulgaris extract powder, the Prunella vulgaris extract powder pharmaceutical active composition that the extracting method of the backflow extraction for the selfheal that the present invention is provided is obtained is up to more than 95%, due to containing effective ingredients most in selfheal in Prunella vulgaris extract powder, using its being used for of preparing treat hypertension insomnia, Yin Yang balancing Chinese medicine foot soaking agent, drug effect increases substantially.The present invention utilizes microwave drying sterilization, it is 2400 2500MHz that cream drug, which will be concentrated into, in microwave frequency, the 35min of drying sterilizing time 25, this process is not due to using high-temperature heating, and sterilizing and drying process is carried out together, at utmost remain the activity of medicine, it is to avoid pharmaceutical activity is destroyed.
Description
Technical field
The invention belongs to Chinese medicine preparation field, and in particular to be had a sleepless night for treating hypertension, the Chinese medicine of Yin Yang balancing steeps enough
The manufacture craft of agent.
Background technology
Chinese medicine is middle medical drugs, is the peculiar medicine of the Chinese tradition traditional Chinese medical science.Chinese medicine refers to all kinds of medicine materical crude slice by processing.Process
Effect, except removing impurity, be easy to preparation and take outer, it is often more important that eliminate or lower the Side effect of medicine,
Change the performance of medicine, strengthen curative effect.Processing total score is water system, fire system, extreme misery conjunction system etc..Water be formed with wash, float, steeping, stain, fine grinding
Deng；Fire, which is formed with, to be forged, big gun, stewing, stir-fry, baking, roasts, processs；Extreme misery closes and is formed with steaming, boils, quench, and carefully containing some in each method
Specific method is planted, its intension is extremely abundant.
Being currently used for regulation blood pressure, the preparation method for the Chinese medicine foot soaking agent for improving sleep quality such as includes：Will as Semen Leonuri,
Spina date seed, selfheal, etc. raw material be ground into 100-300 mesh fine powders, mix, sterilizing, packing.However, preparing in this way
Be used for adjust blood pressure, improve the Chinese medicine foot soaking agent of sleep quality in contain substantial amounts of impurity, pharmaceutical activity is low, and drug effect can not be obtained
To giving full play to, and the time is long in sterilization process, and speed is slow, and effect is poor, energy consumption greatly, and products obtained therefrom active ingredient by
A certain degree of destruction.
The content of the invention
In order to improve utilization ratio of drug, the concentration of medicine is improved, the present invention extracts the active ingredient in selfheal, profit first
Sterilizing is dried with microwave, rate of drying is fast, sterilizing efficiency is high, two techniques are carried out simultaneously, effectively reduction pharmaceutical activity into
That divides is destroyed, is then crushed residual drug, mixes.
It is an object of the invention to provide it is a kind of be used for treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing making work
Skill.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, the technique comprises the following steps：
(1) water of 7.5-8.5 times of parts by weight is added into selfheal, in 85-95 DEG C of backflow extraction 2.5-3.5h, is filtered,
Filtrate is obtained, the water of 5.5-6.5 times of parts by weight is added into filter residue, in 85-95 DEG C of backflow extraction 1.5-2.5h, filtering obtains filtrate,
The water of 3.5-4.5 times of parts by weight is added into filter residue, in 85-95 DEG C of backflow extraction 0.5-1.5h, filtering obtains filtrate, merges three
Secondary gained filtrate, is concentrated into paste, and microwave sterilization dry, pulverize, sieving, obtains Prunella vulgaris extract powder；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 20-25%, spina date seed 15-20%, magnetite 17- processed
22%, Ligusticum wallichii 18-23% and Dryobala nopsaromatica Gaertn. F 0.7-1.2%, are crushed, and then add the step of percentage by weight is 15-20% (1)
Gained Prunella vulgaris extract powder, is granulated, sieving, microwave sterilization drying, obtains described for treating hypertension insomnia, balance the moon
The Chinese medicine foot soaking agent of sun.
The method that the present invention uses three water extractions, extracts the effective ingredient in selfheal.For the first time into selfheal
The water of 7.5-8.5 times of parts by weight is added, selfheal can fully contact with water, then be endured slowly with small fire, in 85-95 DEG C of backflow leaching
Carrying most effective ingredient in 2.5-3.5h, selfheal can be dissolved in water, but now also contain one in filter residue
Quantitative effective ingredient, therefore extracting twice, the immersion infusion previous due to have passed through, contain some in the dregs of a decoction
Moisture, therefore the weight ratio reduction added water, can save the time of infusion and concentration, be also beneficial to effective ingredient fully molten
In Xie Shui.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (1), the water of 7.5-8.5 times of parts by weight is added into selfheal, with 2-3 DEG C/min heating
Speed, is heated to 85-95 DEG C, insulation backflow extraction 2.5-3.5h, filtering obtains filtrate, 5.5-6.5 times of weight is added into filter residue
The water of part, with 2-3 DEG C/min heating rate, is heated to 85-95 DEG C, in 85-95 DEG C of insulation backflow extraction 1.5-2.5h, mistake
Filter, obtains filtrate, and the water of 3.5-4.5 times of parts by weight is added into filter residue, with 2-3 DEG C/min heating rate, 85-95 is heated to
DEG C, in 85-95 DEG C of insulation backflow extraction 0.5-1.5h, filtering obtains filtrate, merges three gained filtrates, be concentrated into paste, microwave
Sterilizing-drying, is crushed, and sieving obtains Prunella vulgaris extract powder.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (1), merges the filtrate of three gained, is then concentrated at 115-125 DEG C.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (1), is concentrated into paste, the relative density of the paste is 1.25-1.3.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (1), crosses 80-120 mesh sieves after crushing.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (1), the humidity of the Prunella vulgaris extract powder is below 7%.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (2), by Semen Leonuri 20-25%, spina date seed 15-20%, magnetite 17-22% processed, Ligusticum wallichii 18-
23% and Dryobala nopsaromatica Gaertn. F 0.7-1.2%, is ground into 80-120 mesh fine powders.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (2), using non-slurry pelletizing.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (2), crosses 50-70 mesh sieves after granulation.
Being used for according to the specific embodiment of the invention treats hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing
Manufacture craft, it is preferable that in step (2), the microwave frequency that microwave sterilization is dried is 2400-2500MHz, and the drying sterilizing time is
25-35min。
Beneficial effect：
1. the method that the present invention utilizes three water extractions, the effective ingredient in selfheal is concentrated and dried, the summer is obtained withered
Careless extract powder, the obtained Prunella vulgaris extract powder Chinese medicine of extracting method of the backflow extraction for the selfheal that the present invention is provided
Thing active component is up to more than 95%, effective due to containing medicines most in selfheal in Prunella vulgaris extract powder
Composition, using its being used for of preparing treat hypertension insomnia, Yin Yang balancing Chinese medicine foot soaking agent, drug effect increases substantially,
Effect to regulation blood pressure, Yin Yang balancing, improvement sleep is increased substantially.
2. the present invention is using microwave drying sterilization, will be concentrated into cream drug in microwave frequency is 2400-2500MHz, is done
Dry sterilizing time 25-35min, this process is not due to using high-temperature heating, and sterilizing and drying process is carried out together, at utmost
Remain the activity of medicine, it is to avoid pharmaceutical activity is destroyed.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below
Detailed description.Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are resulting on the premise of creative work is not made to be owned
Other embodiment, belongs to the scope that the present invention is protected.
Embodiment 1
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 7.5 times of parts by weight is added into selfheal, in 85 DEG C of backflow extraction 3.5h, filtering obtains filtrate, to filter
The water of 5.5 times of parts by weight is added in slag, in 85 DEG C of backflow extraction 2.5h, filtering obtains filtrate, 3.5 times of weight are added into filter residue
Part water, in 85 DEG C of backflow extraction 1.5h, filtering obtains filtrate, merges three gained filtrates, is concentrated into paste, microwave sterilization is done
It is dry, crush, sieving obtains Prunella vulgaris extract powder；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 20%, spina date seed 20%, magnetite 17% processed, Ligusticum wallichii 23%
With Dryobala nopsaromatica Gaertn. F 0.7%, crush, then add Prunella vulgaris extract powder obtained by the step of percentage by weight is 19.3% (1),
Granulation, sieving, microwave sterilization is dried, and obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 2
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 8.5 times of parts by weight is added into selfheal, in 95 DEG C of backflow extraction 2.5h, filtering obtains filtrate, to filter
The water of 6.5 times of parts by weight is added in slag, in 95 DEG C of backflow extraction 1.5h, filtering obtains filtrate, 4.5 times of weight are added into filter residue
Part water, in 95 DEG C of backflow extraction 0.5h, filtering obtains filtrate, merges three gained filtrates, is concentrated into paste, microwave sterilization is done
It is dry, crush, sieving obtains Prunella vulgaris extract powder；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 25%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii 18%
With Dryobala nopsaromatica Gaertn. F 1.2%, crush, then add Prunella vulgaris extract powder obtained by the step of percentage by weight is 18.8% (1),
Granulation, sieving, microwave sterilization is dried, and obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 3
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 8 times of parts by weight is added into selfheal, with 3 DEG C/min heating rate, 90 DEG C is heated to, is incubated back
Stream extraction 3h, filtering obtains filtrate, the water of 6 times of parts by weight is added into filter residue, with 3 DEG C/min heating rate, 90 are heated to
DEG C, in 90 DEG C of insulation backflow extraction 2h, filtering obtains filtrate, the water of 4 times of parts by weight is added into filter residue, with 3 DEG C/min heating
Speed, is heated to 90 DEG C, in 90 DEG C of insulation backflow extraction 1h, and filtering obtains filtrate, merges three gained filtrates, dense at 125 DEG C
Paste is reduced to, the relative density of the paste is 1.3, and microwave sterilization dry, pulverize, and crosses 120 mesh sieves, obtains Prunella vulgaris extract
Powder, the humidity of the Prunella vulgaris extract powder is 6.3%；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18% and Dryobala nopsaromatica Gaertn. F 1.2%, crush as 120 mesh fine powders, then add summer obtained by the step of percentage by weight is 20% (1) withered
Careless extract powder, is granulated using dry granulating machine, crosses 70 mesh sieves, is 2500MHz, drying sterilizing time in microwave frequency
25min, obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 4
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 8.5 times of parts by weight is added into selfheal, with 2 DEG C/min heating rate, 85 DEG C, insulation are heated to
Backflow extraction 3.5h, filtering obtains filtrate, the water of 6.5 times of parts by weight is added into filter residue, with 2 DEG C/min heating rate, heating
To 85 DEG C, 85 DEG C insulation backflow extraction 2.5h, filtering, obtain filtrate, into filter residue add 4.5 times of parts by weight water, with 2 DEG C/
Min heating rate, is heated to 85 DEG C, in 85 DEG C of insulation backflow extraction 1.5h, and filtering obtains filtrate, merges three gained filtrates,
Paste is concentrated at 115 DEG C, the relative density of the paste is 1.25, and microwave sterilization dry, pulverize, and crosses 80 mesh sieves, obtains
Prunella vulgaris extract powder, the humidity of the Prunella vulgaris extract powder is 6.1%；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18% and Dryobala nopsaromatica Gaertn. F 1.2%, crush as 80 mesh fine powders, then add summer obtained by the step of percentage by weight is 20% (1) withered
Careless extract powder, is granulated using dry granulating machine, crosses 50 mesh sieves, is 2400MHz, drying sterilizing time in microwave frequency
35min, obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 5
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 7.5 times of parts by weight is added into selfheal, with 2 DEG C/min heating rate, 85 DEG C, insulation are heated to
Backflow extraction 3.5h, filtering obtains filtrate, the water of 5.5 times of parts by weight is added into filter residue, with 2 DEG C/min heating rate, heating
To 85 DEG C, 85 DEG C insulation backflow extraction 2.5h, filtering, obtain filtrate, into filter residue add 3.5 times of parts by weight water, with 2 DEG C/
Min heating rate, is heated to 85 DEG C, in 85 DEG C of insulation backflow extraction 1.5h, and filtering obtains filtrate, merges three gained filtrates,
Paste is concentrated at 115 DEG C, the relative density of the paste is 1.25, and microwave sterilization dry, pulverize, and crosses 80 mesh sieves, obtains
Prunella vulgaris extract powder, the humidity of the Prunella vulgaris extract powder is 7%；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18% and Dryobala nopsaromatica Gaertn. F 1.2%, crush as 80 mesh fine powders, then add summer obtained by the step of percentage by weight is 20% (1) withered
Careless extract powder, is granulated using dry granulating machine, crosses 50 mesh sieves, is 2400MHz, drying sterilizing time in microwave frequency
35min, obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 6
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 8.5 times of parts by weight is added into selfheal, with 3 DEG C/min heating rate, 95 DEG C, insulation are heated to
Backflow extraction 2.5h, filtering obtains filtrate, the water of 6.5 times of parts by weight is added into filter residue, with 3 DEG C/min heating rate, heating
To 95 DEG C, 95 DEG C insulation backflow extraction 1.5h, filtering, obtain filtrate, into filter residue add 4.5 times of parts by weight water, with 3 DEG C/
Min heating rate, is heated to 95 DEG C, in 95 DEG C of insulation backflow extraction 0.5h, and filtering obtains filtrate, merges three gained filtrates,
Paste is concentrated at 125 DEG C, the relative density of the paste is 1.3, and microwave sterilization dry, pulverize, and crosses 120 mesh sieves, obtains
Prunella vulgaris extract powder, the humidity of the Prunella vulgaris extract powder is 6.2%；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18% and Dryobala nopsaromatica Gaertn. F 1.2%, crush as 120 mesh fine powders, then add summer obtained by the step of percentage by weight is 20% (1) withered
Careless extract powder, is granulated using dry granulating machine, crosses 50 mesh sieves, is 2400MHz, drying sterilizing time in microwave frequency
35min, obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Embodiment 7
For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft, comprise the following steps：
(1) water of 8 times of parts by weight is added into selfheal, with 2.5 DEG C/min heating rate, 90 DEG C, insulation are heated to
Backflow extraction 3h, filtering obtains filtrate, the water of 6 times of parts by weight is added into filter residue, with 2.5 DEG C/min heating rate, is heated to
90 DEG C, in 90 DEG C of insulation backflow extraction 2h, filtering obtains filtrate, the water of 4 times of parts by weight is added into filter residue, with 2.5 DEG C/min's
Heating rate, is heated to 90 DEG C, and in 90 DEG C of insulation backflow extraction 1h, filtering obtains filtrate, merges three gained filtrates, at 115 DEG C
Under be concentrated into paste, the relative density of the paste is 1.26, and microwave sterilization dry, pulverize, and crosses 100 mesh sieves, obtains selfheal
Extract powder, the humidity of the Prunella vulgaris extract powder is 7%；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18% and Dryobala nopsaromatica Gaertn. F 1.2%, crush as 100 mesh fine powders, then add summer obtained by the step of percentage by weight is 20% (1) withered
Careless extract powder, is granulated using dry granulating machine, crosses 60 mesh sieves, is 2500MHz, drying sterilizing time in microwave frequency
30min, obtains described for treating hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
Experimental example
Using prior art by percentage by weight be Semen Leonuri 23.8%, spina date seed 15%, magnetite 22% processed, Ligusticum wallichii
18%, the selfheal of Dryobala nopsaromatica Gaertn. F 1.2% and 20% is ground into 300 mesh fine powders, mixes, and is sterilized 24 hours, is used using Co 60
In the Chinese medicine foot soaking agent for adjusting blood pressure, improvement sleep quality.
Impurity content is 18.9% in the foot-bath agent obtained using prior art, and what embodiment 7 was obtained is used to treat high blood
Impurity content is 2.1% in pressure insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing, prepared by the method that this explanation is provided using the present invention
Had a sleepless night for treating hypertension, the Chinese medicine foot soaking agent impurity content of Yin Yang balancing is substantially reduced.What prior art was obtained is used to adjust
The Chinese medicine foot soaking agent for saving blood pressure, improvement sleep quality is 18% to the minimum inhibitory concentration of Escherichia coli and staphylococcus aureus
With 24%, what embodiment 7 was obtained is used to treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing to Escherichia coli and golden yellow
Staphylococcic minimum inhibitory concentration is 12% and 16%, and what the method that this explanation is provided using the present invention was obtained is used to treat height
The active component of medicine is significantly improved in blood pressure insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. for treating hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, it is characterised in that the technique bag
Include following steps：
(1) water of 7.5-8.5 times of parts by weight is added into selfheal, in 85-95 DEG C of backflow backflow extraction 2.5-3.5h, is filtered,
Filtrate is obtained, the water of 5.5-6.5 times of parts by weight is added into filter residue, in 85-95 DEG C of backflow extraction 1.5-2.5h, filtering obtains filtrate,
The water of 3.5-4.5 times of parts by weight is added into filter residue, in 85-95 DEG C of backflow extraction 0.5-1.5h, filtering obtains filtrate, merges three
Secondary gained filtrate, is concentrated into paste, and microwave sterilization dry, pulverize, sieving, obtains Prunella vulgaris extract powder；
(2) bulk drug of following percentage by weight is taken：Semen Leonuri 20-25%, spina date seed 15-20%, magnetite 17-22% processed, river
Rhizome of chuanxiong 18-23% and Dryobala nopsaromatica Gaertn. F 0.7-1.2%, is crushed, and then adds the summer obtained by the step of percentage by weight is 15-20% (1)
Withered grass extract powder, is granulated, and sieving, microwave sterilization is dried, and obtains described for treating in hypertension insomnia, Yin Yang balancing
Medicine foot soaking agent.
2. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (1), the water of 7.5-8.5 times of parts by weight is added into selfheal, with 2-3 DEG C/min heating rate, plus
Heat is to 85-95 DEG C, and insulation backflow extraction 2.5-3.5h, filtering obtains filtrate, the water of 5.5-6.5 times of parts by weight is added into filter residue,
With 2-3 DEG C/min heating rate, 85-95 DEG C is heated to, in 85-95 DEG C of insulation backflow extraction 1.5-2.5h, filtering must be filtered
Liquid, the water of 3.5-4.5 times of parts by weight is added into filter residue, with 2-3 DEG C/min heating rate, 85-95 DEG C is heated to, in 85-
95 DEG C of insulation backflow extraction 0.5-1.5h, filtering obtains filtrate, merges three gained filtrates, be concentrated into paste, microwave sterilization is done
It is dry, crush, sieving obtains Prunella vulgaris extract powder.
3. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (1), merges the filtrate of three gained, then concentrated at 115-125 DEG C.
4. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (1), is concentrated into paste, the relative density of the paste is 1.25-1.3.
5. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (1), 80-120 mesh sieves is crossed after crushing.
6. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (1), the humidity of the Prunella vulgaris extract powder is below 7%.
7. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
Be characterised by, in step (2), by Semen Leonuri 20-25%, spina date seed 15-20%, magnetite 17-22% processed, Ligusticum wallichii 18-23% and
Dryobala nopsaromatica Gaertn. F 0.7-1.2%, is crushed as 80-120 mesh fine powders.
8. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (2), using non-slurry pelletizing.
9. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing, its
It is characterised by, in step (2), 50-70 mesh sieves is crossed after granulation.
10. according to claim 1 be used to treat hypertension insomnia, the manufacture craft of the Chinese medicine foot soaking agent of Yin Yang balancing,
Characterized in that, in step (2), the microwave frequency that microwave sterilization is dried is 2400-2500MHz, the drying sterilizing time is 25-
35min。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710531406.6A CN107260821A (en) | 2017-06-30 | 2017-06-30 | For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft |
| KR1020170106674A KR20190003281A (en) | 2017-06-30 | 2017-08-23 | Process for preparing Chinese medicine foot soaking agent for treating hypertension, insomnia and balancing yin and Yang |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710531406.6A CN107260821A (en) | 2017-06-30 | 2017-06-30 | For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107260821A true CN107260821A (en) | 2017-10-20 |
Family
ID=60071251
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710531406.6A Pending CN107260821A (en) | 2017-06-30 | 2017-06-30 | For treat hypertension insomnia, the Chinese medicine foot soaking agent of Yin Yang balancing manufacture craft |
Country Status (2)
| Country | Link |
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| KR (1) | KR20190003281A (en) |
| CN (1) | CN107260821A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108013455A (en) * | 2017-12-14 | 2018-05-11 | 德施普科技发展温州有限公司 | A kind of health-preserving food and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737730B (en) * | 2022-11-17 | 2023-08-22 | 南京中医药大学 | Traditional Chinese medicine composition for treating plantar fasciitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259174A (en) * | 2008-04-23 | 2008-09-10 | 赵广钧 | Chinese medicine foot soaking agent for regulating blood pressure and improving sleeping quality |
-
2017
- 2017-06-30 CN CN201710531406.6A patent/CN107260821A/en active Pending
- 2017-08-23 KR KR1020170106674A patent/KR20190003281A/en not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259174A (en) * | 2008-04-23 | 2008-09-10 | 赵广钧 | Chinese medicine foot soaking agent for regulating blood pressure and improving sleeping quality |
Non-Patent Citations (2)
| Title |
|---|
| YUBING BAI: "Phytochemistry and pharmacological activities of the genus Prunella", 《FOOD CHEMISTRY》 * |
| 王泽等: "《制剂设备》", 31 January 2013, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108013455A (en) * | 2017-12-14 | 2018-05-11 | 德施普科技发展温州有限公司 | A kind of health-preserving food and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| KR20190003281A (en) | 2019-01-09 |
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Application publication date: 20171020 |