CN115737730B - Traditional Chinese medicine composition for treating plantar fasciitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating plantar fasciitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine formula for treating plantar fasciitis and a preparation method thereof, wherein the traditional Chinese medicine formula comprises the following raw materials in parts by weight: 4-6 parts of angelica sinensis, 2-4 parts of ligusticum wallichii, 2-4 parts of radix salviae miltiorrhizae, 1-2 parts of ginseng and 1-2 parts of saffron. Pulverizing the above five Chinese medicinal materials respectively, sieving with No. six sieve (100 mesh) defined in the general case of Chinese pharmacopoeia (one part) of 2020 edition to obtain fine powder, and mixing the fine powder according to the proportion. The traditional Chinese medicine formula provided by the invention cooperatively plays the functions of replenishing blood and activating blood, activating blood and promoting qi, activating qi-flowing and removing blood stasis, removing blood stasis and relieving pain, cooling blood and detoxifying of the formula medicine under the guidance of the theory of traditional Chinese medicine, and achieves the satisfactory effect of treating plantar fasciitis due to excessive filling of qi and blood of the sole.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating plantar fasciitis and a preparation method thereof.
Background
Plantar fasciitis is also called plantar fasciitis, belongs to one of calcaneodynia, and is caused by aseptic inflammation of plantar tendons or fascia. The most common symptoms are pain and discomfort of the heel, with pressure points often being in the sole near the heel, sometimes pressure pain is severe and persists. The pain feeling is obvious in the morning, the pain feeling is aggravated when the patient walks excessively, and the serious patient has the pain feeling even when standing and resting. The high-heeled shoes, long-running lovers, soldiers and the like are high-incidence people of the disease, and the incidence rate of the high-incidence people in all ages is distributed between 30 and 40 years (22%), between 41 and 50 years (36%), between 51 and 60 years (32%), between 61 and 70 years (2%), more than 70 years (8%), and the majority of the high-incidence people in 40 to 60 years. Plantar fasciitis is common and frequent, often occurs after excessive exercise, about 10% of the general population suffers from plantar fasciitis, and 20% -30% of patients still fail to achieve effective relief through conservative treatment. Investigation of a community population found that the elderly with painful plantar fasciitis reached 6.9% and the disease affected the patient's daily life, walking up and down stairs. For the treatment of the disease, the combination of anti-inflammatory drugs and external physical treatment is mostly selected to relieve pain, and the treatment cycle is longer, the effect is slow, etc., but the eradication is difficult to achieve, and the disease is repeated. Surgical treatments, i.e., fasciotomies, such as percutaneous fasciotomies and endoscopic fascia incisions; the non-operative treatment comprises low intensity laser treatment, direct current ion-induced electric therapy, ultrasonic treatment, physical factor treatment such as divergent external shock wave, physical treatment such as traction, foot orthosis and night splint treatment, and corticosteroid plantar injection. Plantar injection therapy and surgical therapy are accepted, but both of them bring about a number of complications. Therefore, there is a need for a simple, easy, and effective method for alleviating and treating pain in patients with plantar fasciitis.
At present, the physical therapy for improving or treating plantar fasciitis has a relieving effect by a special insole with a modified appearance structure, for example, the plantar pressure of a patient can be relieved and dispersed to a certain extent by using the insole with the arch support, and the tensile force born by plantar fasciitis is reduced when the lower limb is loaded, so that the injury of traction to plantar fasciitis is reduced. However, the lack of effective traditional Chinese medicine formula for synergistic intervention is easy to relapse, and the satisfactory beneficial effect is difficult to obtain.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating plantar fasciitis, which comprises the following raw materials in parts by weight: 4-6 parts of angelica sinensis, 2-4 parts of ligusticum wallichii, 2-4 parts of radix salviae miltiorrhizae, 1-2 parts of ginseng and 1-2 parts of saffron.
As a further improvement of the invention, the traditional Chinese medicine composition consists of the following raw materials in parts by weight: 5 parts of Chinese angelica, 3 parts of szechuan lovage rhizome, 3 parts of red sage root, 1 part of ginseng and 1 part of saffron.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition, which is characterized in that five traditional Chinese medicine raw materials are respectively crushed and sieved by a 100-mesh sieve to obtain fine powder of each traditional Chinese medicine, and the fine powder of each traditional Chinese medicine is taken according to the mass ratio and uniformly mixed.
As an improvement of the invention, 5-7 g of the powder is taken and put into a proper cloth bag with good air permeability such as cotton cloth, and the cloth bag is sewn into a medicine bag to be lined at the heel of the insole, or the insole with the replaceable medicine bag design is used at the root of the foot, and the medicine bag is replaced for 1 time per week.
In the knowledge of traditional Chinese medicine, as early as "heel pain" in Huangdi's interior meridian, for example, in "cloud" blood qi is abundant "in Ling Pi Jing, yin and Yin Ji Shi fifteen people, the heel is full of the heel and hard, the qi is less and blood is more, the heel is empty, the blood and qi are less, and the tendons are turned well and the heel is painful. Modern medicine considers plantar fasciitis to be caused by degeneration, repeated micro injury and aseptic inflammation of plantar fasciitis calcaneal dead points. On pathological tissues, collagen fiber degeneration and fiber arrangement disorder of plantar fascia can be seen, and vascular fibroblasts with increased mucus matrix and hyperproliferation are accompanied, but inflammatory cells such as leucocytes, lymphocytes or macrophages are rare. Fascia collagen fiber degeneration, calcaneus dead center degeneration, repeated microdamage, fiber arrangement disorder and the like are related to malnutrition of the cell tissue of the sole part, and function degeneration and weakening, so that normal physiological functions are changed. The traditional Chinese medicine formula provided by the invention aims at eliminating pathogenic pathogenesis by taking filling sole qi and blood and nourishing local cell tissues as treatment rules in view of traditional Chinese medicine and modern medical pathogenesis of plantar fasciitis under the guidance of a traditional Chinese medicine theory, and takes strengthening tendons and bones, resisting bacteria, diminishing inflammation and relieving pain as treatment rules instead of using manifestations. According to the characteristics of volatile components contained in the prescription drugs, the traditional external application method of traditional Chinese medicine is mainly used for drug administration (percutaneous or transdermal absorption), the functions of the whole prescription drugs are utilized, the effects of enriching and activating blood, invigorating primordial qi, promoting qi and activating blood, activating blood and removing stasis, promoting qi and removing stasis and relieving pain, cooling blood and detoxifying of the prescription drugs are exerted, and the effect of improving and treating plantar fasciitis is achieved. In short, the therapeutic effect is achieved by replenishing qi and blood in the local cell tissue of heel by tonifying blood and activating blood and removing stasis, tonifying qi and promoting qi circulation and qi and blood, and simultaneously preventing excessive qi and blood, and cooling blood and removing toxic substances. From the modern medical point of view, the local tissue cells of the heel are nourished by filling with blood and qi, and the degeneration of fascia collagen fibers, the degeneration of calcaneus dead points, micro injury and the like are improved and recovered. Specifically, the main efficacy of the Chinese angelica for enriching blood and activating blood is taken as a monarch drug; taking the effects of activating blood circulation, promoting qi circulation and removing blood stasis of the ligusticum wallichii and the red sage root as ministerial drugs; the ginseng has the effects of reinforcing primordial qi, assisting the effects of activating blood and the angelica and the ligusticum wallichii, and taking the effects of cooling blood and detoxifying and activating blood and dissolving stasis of the stigma croci as adjuvant and guiding drugs. The therapeutic principle of replenishing blood and activating blood, promoting blood circulation and activating qi-flowing, promoting qi-flowing and removing blood stasis and relieving pain, cooling blood and removing toxin is achieved through the combination of the medicines, so that the effect of improving and treating plantar fasciitis is achieved due to sufficient qi and blood at the sole.
Advantageous effects
Compared with the prior art, the traditional Chinese medicine formula for improving and treating plantar fasciitis has the following outstanding beneficial effects:
1. the external treatment method of traditional Chinese medicine has a long application history for thousands of years, the prescription medicines are all traditional Chinese medicines containing volatile oil, the medicinal materials are aromatic, especially the volatile oil content of angelica sinensis, ligusticum wallichii, ginseng and stigma croci is larger, and the theory of traditional Chinese medicine considers that aromatic medicinal materials have the effects of pungent channeling, dysmenorrhea and activating blood and the volatile components have the characteristic of percutaneous absorption. The Chinese medicinal composition has the advantages of simple and convenient operation, small dosage, strong pertinence to the affected part, low price, no influence on the daily work and life of the patient and the like while achieving the satisfactory effect.
2. The traditional Chinese medicine provided by the invention is a clinical common traditional Chinese medicine which is received in the Chinese pharmacopoeia (one part) of 2020 edition, is nontoxic, is externally used, and is safe and safe for patients to take.
3. Based on the symptoms of patients with plantar fasciitis, mainly pain and discomfort of heels, tenderness points are often near the heels of the soles, sometimes severe tenderness exists continuously, and the resulting pain is characterized by pulsatility, burning and stinging. The prescription scheme design is carried out by selecting traditional Chinese medicines with the effects of promoting blood circulation by removing blood stasis, promoting qi circulation by relieving pain, cooling blood and removing toxin and the like, and the characteristic traditional Chinese medicines with the feasibility of external use, so that the beneficial effect of satisfactory curative effect is finally achieved.
Detailed Description
The traditional Chinese medicine formula provided by the invention comprises five medicinal materials: chinese angelica, szechuan lovage rhizome, red sage root, ginseng and saffron, and the five medicaments are all varieties collected in the Chinese pharmacopoeia (one part) of 2020 edition.
According to the edition 2020 "Chinese pharmacopoeia" (section), the five traditional Chinese medicines have the following main indications:
angelica (ANGELICAE SINENSIS RADIX): sweet, pungent and warm. It enters liver, heart and spleen meridians. Replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, skin ulcer, and constipation due to intestinal dryness.
Ligusticum wallichii (CHUANXIONG RHIZOMA): pungent and warm. Enter liver, gallbladder and pericardium meridians. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for treating chest pain, hypochondrium pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal pain, headache, and rheumatalgia.
Root of red-rooted salvia (SALVIAE MILTIORRHIZAE RADIX ET RHIZOMA): bitter and slightly cold. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle. Can be used for treating chest pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.
Ginseng (GINSENG RADIX ET RHIZOMA): sweet, slightly bitter and slightly warm. It enters spleen, lung, heart and kidney meridians. The medicine has the functions of invigorating primordial qi, restoring pulse, strengthening spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind and improving intelligence. Can be used for treating asthenia, listlessness, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, asthma and cough, body fluid consumption, thirst, internal heat, thirst, deficiency of qi and blood, deficiency of both long-term illness, palpitation, insomnia, sexual impotence, and cold womb.
STIGMA CROCI (CROCI STIGMA): sweet and flat. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, cooling blood, removing toxic substance, resolving depression and tranquillizing. Can be used for treating amenorrhea, abdominal mass, puerperal stagnation, toxic heat, speckle, melancholy, chest distress, palpitation, and mania.
Example 1
The medicine of the embodiment comprises the following raw materials in parts by weight: 5g of Chinese angelica, 3g of szechuan lovage rhizome, 3g of red sage root, 1g of ginseng and 1g of saffron are respectively crushed into a sufficient amount of five traditional Chinese medicines, and the five traditional Chinese medicines are sieved by a No. six sieve (100 meshes) specified by the general provisions of Chinese pharmacopoeia (one part) of 2020 edition to obtain fine powder of each traditional Chinese medicine, and the fine powder is uniformly mixed.
Example 2
The medicine of the embodiment comprises the following raw materials in parts by weight: 5g of Chinese angelica, 4g of szechuan lovage rhizome, 2g of red sage root, 2g of ginseng and 2g of saffron, respectively crushing a sufficient amount of five traditional Chinese medicines, sieving with a No. six sieve (100 meshes) specified by the general rules of Chinese pharmacopoeia (one part) of 2020 edition, and uniformly mixing.
Example 3 clinical observation experiment of the treatment of plantar fasciitis of the present invention
(1) General data
The patients with standard plantar keratitis are selected to be treated in the auxiliary hospitals of the traditional Chinese medicine university of Nanjing (the middle hospitals of Jiangsu province) and the auxiliary combined hospitals of the traditional Chinese medicine university of Nanjing (the combined hospitals of the traditional Chinese and Western medicine of Nanjing province) from 3 months in 2020 to 3 months in 2022, and are distributed to a treatment group and a control group according to the standard patients with plantar keratitis, 55 cases of each group are 110 patients, the ages of the patients are 30-60 years, and the common data comparison difference of the patients in 2 groups has no statistical significance (P is more than 0.05), so that the patients are comparable. The average age of the treatment group is 51.42 years, and the average course of disease is 5.56+/-1.96 months; the average age of the control group was 52.61 years, and the average course of disease was 5.35.+ -. 2.10 months.
(2) Diagnostic criteria
According to the diagnosis and treatment standard of plantar fasciitis among the traditional Chinese medicine disease diagnosis and treatment standards promulgated by the national medical administration in 1994: (1) slow onset, can have a history of days or even years, and mostly occurs in people with fatter constitution above middle-aged people, and has a certain relation with senile degenerative changes; (2) the pain of the sole of the foot is aggravated when walking or standing, and is more obvious when walking on uneven roads; (3) the affected part is generally free from red swelling, and has localized tenderness at the inner edge of the sole, and the thickened edema of plantar aponeurosis can be seen by B ultrasonic and Magnetic Resonance Imaging (MRI) examination.
(3) Inclusion criteria
Meets the diagnostic criteria; agreeing to participate in the test, having good compliance, and signing an informed consent; age 30-60 years, and is not limited for men and women.
(4) Exclusion criteria
(1) Gestation period, blood system diseases, serious internal diseases and diabetes with poor blood sugar control; (2) fracture, foot contusion, lower limb neuropathy and lumbar vertebra lesion; (3) continuously taking analgesic drugs for more than 1 week; foot skin crumple and inflammatory exudation; (4) the test is not matched in the middle, the withdrawal or follow-up is lost, and the clinical data is incomplete.
(5) Therapeutic method
Treatment group: the powder mixture was prepared as in example 1, 6 g was placed in a self-made cotton bag (similar in size to the heel portion of a typical insole for a patient), sewn into a bag lining at the heel of the insole, the bag was sewn into the heel of the insole, placed in a shoe, and worn with a conventional life of the insole containing the bag, or used with an insole containing a replaceable bag design at the heel of the foot, and the bag was replaced 1 time per week.
Control group: aceclofenac tablets are orally taken, 0.1g each time, 2 times per day; the glucosamine hydrochloride capsule is orally taken at 0.48mg each time, 3 times per day, and half an hour after meal.
Treatment course: 7 days is 1 course of treatment, and 2 groups are all treated for 4 courses of treatment, and the effect is observed.
(6) Index observation
Pain score: subjective pain sensation in subjects was measured using the international pain digital rating scale (NRS). Namely, pain is classified into 1-10 grades, the greater the number, the more serious the pain, 0 is painless, 10 is severe pain, the corresponding pain degree is selected by the patient according to self feeling, and the pain is classified as follows: 1 to 3 are classified as mild pain, 4 to 6 are classified as moderate pain, and 8 to 10 are classified as severe pain. The observation time point is the pain degree when the patient starts walking after keeping sitting for 30 minutes before the treatment and after the end of each treatment.
Efficacy assessment criteria: (1) clinical recovery: the symptoms of local swelling, pain and the like of the patient disappear, the plantar pain point disappears, and the normal function is recovered; (2) the effect is shown: the local swelling and pain are obviously reduced, the plantar pain point is improved, and walking is not difficult; (3) the method is effective: partial swelling and pain are reduced, the pain points on the sole of the foot are improved, the pain is reduced slightly, and walking is still difficult; (4) invalidation: no improvement before and after treatment. Total effective rate= (clinical cure + onset + efficacy)) number of cases/total number of cases x 100%.
(7) Statistical method
Analysis was performed using SPSS 24.0 statistical software, and the measured data were mean.+ -. Standard deviationThe method shows that the comparison before and after the treatment in the group adopts paired t test, the comparison between the groups adopts independent sample t test, and the counting data adopts X 2 Checking, P<A difference of 0.05 is statistically significant.
(8) Results
Pain score: subjects were scored on an internationally universal pain digital rating scale, with no statistical significance (P > 0.05) for NRS score differences for 2 groups of patients prior to treatment; after treatment, the pain scores of the patients in the treatment group and the control group were significantly different, and were significantly reduced (P < 0.01) compared to the patients before treatment, and NRS scores after treatment were lower (P < 0.05) compared to the control group. The detailed results are shown in Table 1.
Table 1 comparison of plantar fasciitis pain scores for the treated and control groupsDividing into two parts
Note that: the pre-treatment was compared to the control group, ★ representing P>0.05; in comparison with the pre-treatment period, ▲ representing P<0.01; after the treatment, compared with the control group, ● representing P<0.05。
Clinical effects: the total effective rate of the treatment group is 100.00% (55/55), the total effective rate of the control group is 74.55% (41/55), and the difference of the 2 groups is statistically significant (P < 0.01); the clinical cure rate of the treatment group is obviously higher than that of the control group, and the results are shown in Table 2 in detail.
Table 2 comparison of plantar fasciitis efficacy in the treated group with the control group [ number of cases (%)
Note that: in comparison with the control group, ★ representing P<0.01。
EXAMPLE 4 typical case
(1) Liu Mou female, age 46, left heel pain 6 months, aggravated for 1 month. The pain feeling is obvious when the left heel is started in the morning without obvious cause before half a year, the pain is intermittently started, the pain pressing point is usually near the heel of the sole, the pain is aggravated after the activity, and the rest can be relieved. Pain aggravated before one month and attacks frequently. The pain is obviously relieved after the insole heel is sewn by the medicine bag of the formula 1 of the example, the medicine bag is replaced 1 time every 7 days, the medicine bag is continuously used for 4 weeks, the pain symptoms disappear, the normal state is recovered, and the pain does not recur after half a year of follow-up visit.
(2) Li Mou the male was 54 years old and had pain in the right heel for 4 months, with half a month aggravated. The pain feeling is obvious when the right heel is started in the morning without obvious cause before 4 months, the pain is intermittently started, the pain pressing point is usually near the heel of the sole, the pain frequency is increased after the activity, and the rest can be relieved. The pain is severe before half a month, and the pain persists, the pulsatility and the stinging somatic sense are obvious, and even the pain is felt when standing for rest. The pain is obviously relieved after the insole heel is sewn by the medicine bag of the formula 1 of the example, the medicine bag is replaced 1 time every 7 days, the medicine bag is continuously used for 4 weeks, the pain symptoms disappear, the normal state is recovered, and the pain does not recur after half a year of follow-up visit.
(3) Zhang Mou, female, age 48, right heel pain 3 months, aggravated for 1 week. For working reasons, when the high-heeled shoes are worn for a long time, the right heel is pricked once when the user stands for rest for 3 months, then the right heel is pricked after the user walks for a long time, the frequency is increased, and the user has improvement after the user has rest. Pain is aggravated and frequency is increased before 1 week, and the tenderness is severe, which has affected normal work. The medicine bag of the formula 1 of the embodiment is used for sewing the heel part of the insole, pain is obviously relieved after the medicine bag is used for 1 week, the medicine bag is replaced for 1 time every 7 days, the medicine bag is continuously used for 4 weeks, pain symptoms disappear, the normal state is recovered, the patient is ordered to pay attention to shortening the walking time of wearing high-heeled shoes at ordinary times after the recovery, and no recurrence occurs after half a year of follow-up.
Claims (4)
1. The external traditional Chinese medicine composition for treating plantar fasciitis is characterized by being prepared from the following raw materials in parts by weight: 4-6 parts of angelica sinensis, 2-4 parts of ligusticum wallichii, 2-4 parts of radix salviae miltiorrhizae, 1-2 parts of ginseng and 1-2 parts of saffron.
2. The external traditional Chinese medicine composition for treating plantar fasciitis according to claim 1, wherein the external traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 parts of Chinese angelica, 3 parts of szechuan lovage rhizome, 3 parts of red sage root, 1 part of ginseng and 1 part of saffron.
3. The external traditional Chinese medicine composition for treating plantar fasciitis according to claim 1 or 2, wherein the preparation method of the external traditional Chinese medicine composition comprises the steps of respectively crushing five raw materials to obtain fine powder, and uniformly mixing the fine powder according to a proportion.
4. The external use Chinese medicinal composition for treating plantar fasciitis according to claim 3, wherein the fine powder is in accordance with a sieve No. six (100 mesh) prescribed by the chinese pharmacopoeia (part) of the year 2020.
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