CN115737730A - Traditional Chinese medicine composition for treating plantar fasciitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating plantar fasciitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine formula for treating plantar fasciitis and a preparation method thereof, wherein the traditional Chinese medicine formula comprises the following raw materials in parts by weight: 4-6 parts of angelica, 2-4 parts of ligusticum wallichii, 2-4 parts of salvia miltiorrhiza, 1-2 parts of ginseng and 1-2 parts of saffron. The five traditional Chinese medicines are respectively crushed and sieved by a No. six sieve (100 meshes) specified in every case of the 'Chinese pharmacopoeia' (one part) of 2020 year edition to obtain fine powder, and the fine powder is uniformly mixed according to the proportion. The traditional Chinese medicine formula provided by the invention is guided by the theory of traditional Chinese medicine, and the effects of enriching blood and activating blood, activating blood and promoting qi circulation, promoting qi circulation and removing blood stasis, removing blood stasis and relieving pain, and cooling blood and removing toxicity of the formula medicine are cooperatively exerted, so that the satisfactory effect of treating plantar fasciitis due to abundant qi and blood of soles is achieved.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating plantar fasciitis and a preparation method thereof.
Background
Plantar fasciitis, also known as plantar fasciitis, belongs to one of calcaneodynia and is caused by aseptic inflammation of tendons or fascia of the sole. The most common symptoms are pain and discomfort at the heel, with the tender point often near the heel of the foot, sometimes with more intense and persistent tenderness. The pain feeling is obvious in morning, the pain feeling is aggravated when the patient is over walking, and the pain feeling is also felt when the patient is seriously suffered from even standing for rest. The people wearing high-heeled shoes for a long time, long-distance running fans, soldiers and the like are high-incidence people of the disease, and the incidence rates of the adults in all age groups are 30-40 years (22%), 41-50 years (36%), 51-60 years (32%), 61-70 years (2%) and more than 70 years (8%), and the number of the adults in all age groups is 40-60. Plantar fasciitis is common and frequent, often occurring after excessive exercise, with about 10% of the general population suffering from plantar fasciitis, and still 20-30% failing to achieve effective relief by conservative treatment. Investigation of a community population finds that the number of elderly with painful plantar fasciitis reaches 6.9%, and the disease affects daily life, walking, going upstairs and downstairs of patients. For the treatment of the disease, anti-inflammatory drugs and external physical therapy are mostly selected to be combined to relieve pain, the treatment period is long, the effect is slow and the like, but the disease is difficult to eradicate, so that the disease condition is repeated. Surgical treatment, i.e., fasciotomy, such as percutaneous fasciotomy and endoscopic fasciotomy; the non-operative treatment comprises physical factor treatment such as low-intensity laser treatment, direct current iontophoresis electrotherapy, ultrasonic treatment, divergent external shock wave treatment and the like, physical treatment such as traction, foot orthotics, night splint treatment and the like, corticosteroid plantar injection and the like. Both plantar injection therapy and surgical treatment are well recognized, but both of these approaches have many complications. Therefore, a simple, convenient and effective method for relieving and treating pain is urgently needed for patients with plantar fasciitis.
At present, the physical therapy for improving or treating plantar fasciitis is realized by a purpose-made insole with a modified appearance structure to play a role in relieving, for example, when the insole with arch support is used, the pressure of the sole of a patient can be relieved and dispersed to a certain extent, and when the lower limb bears the weight, the pulling force applied to the plantar fasciae is effectively reduced, so that the injury of the traction to the plantar fasciae is reduced. But the traditional Chinese medicine composition is lack of effective synergistic intervention, is easy to relapse, and is difficult to obtain satisfactory beneficial effects.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating plantar fasciitis, which comprises the following raw materials in parts by weight: 4 to 6 portions of angelica, 2 to 4 portions of Szechuan lovage rhizome, 2 to 4 portions of salvia miltiorrhiza, 1 to 2 portions of ginseng and 1 to 2 portions of saffron.
As a further improvement of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 parts of angelica, 3 parts of ligusticum wallichii, 3 parts of salvia miltiorrhiza, 1 part of ginseng and 1 part of saffron.
The other purpose of the invention is to provide a preparation method of the traditional Chinese medicine composition, which comprises the steps of respectively crushing the five traditional Chinese medicine raw materials, sieving the crushed raw materials with a 100-mesh sieve to obtain traditional Chinese medicine fine powder, taking the traditional Chinese medicine fine powder according to the mass ratio, and uniformly mixing the traditional Chinese medicine fine powder.
As an improvement of the invention, 5-7 g of the powder is taken and put into a proper cloth bag with good air permeability such as cotton cloth, and the medicine bag is sewed to be lined at the heel of the insole, or the insole with the design of the replaceable medicine bag at the foot root is used, and the medicine bag is replaced 1 time per week.
On the basis of the understanding of traditional Chinese medicine, the name of heel pain is existed as early as Huangdi's classic on medicine, for example, if the blood and qi are abundant, the heel is full and firm, the qi is less and the blood is much, the heel is empty, the blood and qi are all less, and the pain is caused by the transformation of the tendon and the heel. Modern medicine considers that plantar fasciitis is caused by degeneration, repeated micro-damage and aseptic inflammation of plantar fascia calcaneus dead center. Pathological tissues show degeneration of collagen fibers and disorganization of fibers of plantar fascia, vascular fibroblasts with increased mucus matrix and hyperproliferation, and inflammatory cells such as leukocytes, lymphocytes or macrophages are rare. Fascial collagen fiber degeneration, calcaneus stop degeneration, repeated micro-injury, fiber arrangement disorder and the like are related to malnutrition and functional degeneration of local cell tissues of the sole of the foot, so that the normal physiological function is changed. Under the guidance of the theory of traditional Chinese medicine and pharmacology, in view of the pathogenesis of traditional Chinese medicine and modern medicine of plantar fasciitis, the traditional Chinese medicine formula provided by the invention takes the effects of eliminating the pathogenesis by mainly filling plantar qi and blood and nourishing local cell tissues as a treatment principle, rather than taking the manifestation of strengthening bones and muscles, resisting bacteria, diminishing inflammation and relieving pain as the treatment principle. According to the characteristics of volatile components contained in the prescription drugs, the traditional external application method (percutaneous or transdermal absorption) of the traditional Chinese medicine is emphasized, and the effects of enriching and activating blood, greatly reinforcing primordial qi, promoting qi and blood circulation, activating blood circulation to remove blood stasis, promoting qi circulation to remove blood stasis and relieving pain, and cooling blood and removing toxicity of the component drugs are exerted by the integral effect of the prescription drugs, so that the effect of improving and treating the plantar fasciitis is achieved. In short, the treatment purpose is achieved by replenishing blood, activating blood, removing stasis, invigorating qi, promoting qi circulation, and replenishing qi and blood in local cell tissues of the heel, and preventing excess qi and blood, and by using blood-cooling and detoxifying herbs together. From the modern medicine perspective, the blood and qi are filled to nourish the local tissue cells of the heel, and the degeneration of fascia collagen fibers, the degeneration of calcaneus stop, micro-injury and the like are improved and recovered. In particular, the formula takes the main effects of blood enriching and activating of angelica as monarch drug; the effects of the ligusticum wallichii and the salvia miltiorrhiza for promoting blood circulation, promoting qi circulation and removing blood stasis are taken as ministerial drugs; the ginseng is taken as an adjuvant drug with the functions of tonifying primordial qi, assisting the effects of promoting blood circulation of angelica and ligusticum wallichii, and the saffron has the functions of cooling blood, removing toxicity, promoting blood circulation and removing blood stasis. Through the combination of the medicines, the effects of enriching and activating blood, promoting blood circulation and activating qi, promoting qi circulation and removing blood stasis to relieve pain, cooling blood and removing toxicity and the like are achieved, and the effects of improving and treating plantar fasciitis are achieved.
Advantageous effects
Compared with the prior art, the traditional Chinese medicine formula for improving and treating plantar fasciitis provided by the invention has the following outstanding beneficial effects:
1. the traditional Chinese medicine external treatment method has a long application history for thousands of years, the medicines in the formula are all traditional Chinese medicines containing volatile oil, the medicinal materials are aromatic, especially the volatile oil content of the angelica, the ligusticum wallichii, the ginseng and the saffron is higher, the traditional Chinese medicine theory considers that the aromatic medicinal materials have the effects of pungent channeling, dysmenorrhea and activating blood, and the volatile components have the characteristic of percutaneous absorption. The traditional Chinese medicine preparation has the advantages of simple and convenient use, small dosage, strong effect on the affected part, low price, no influence on the daily work and life of a patient and the like while achieving a satisfactory effect.
2. The traditional Chinese medicine formula provided by the invention is a common clinical traditional Chinese medicine collected in the 'Chinese pharmacopoeia' (one part) of 2020 edition, is nontoxic and externally used, and is safe and relieved for patients to use.
3. Based on the symptoms of a patient with plantar fasciitis, the pain and discomfort of heels are mainly caused, the pressure pain points are usually near the heels of the soles, sometimes the pressure pain is severe and exists continuously, and the caused pain is characterized by pulsation, burning and stabbing pain. The traditional Chinese medicine with reliable curative effects of promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain, cooling blood and detoxifying and the like is selected, and the traditional Chinese medicine with the characteristics of feasibility for external use is subjected to formula scheme design, so that the beneficial effect of satisfactory curative effect is finally achieved.
Detailed Description
The traditional Chinese medicine formula provided by the invention comprises five medicinal materials: angelica, rhizoma ligustici wallichii, salvia miltiorrhiza, ginseng and saffron, and the five medicines are all collected and carried by 'Chinese pharmacopoeia' (one part) of 2020 edition.
According to the 'Chinese pharmacopoeia' (one part) of 2020 edition, the five traditional Chinese medicines have the following main indications of property, flavor, channel tropism and function:
angelica SINENSIS (Angelica SINENSIS RADIX): sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation.
RHIZOMA Chuanxiong (Chuanxiong rhizome): pungent and warm. It enters liver, gallbladder and pericardium meridians. Activate blood and move qi, dispel wind and alleviate pain. Can be used for treating thoracic obstruction, cardialgia, pricking pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, headache, and rheumatalgia.
Salvia miltiorrhiza (Salvia MILTIORRHIZAE RADIX ET RHIZOMA): bitter and slightly cold. It enters heart and liver meridians. Promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. Can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Ginseng (Ginseng RADIX ET RHIZOMA): sweet, slightly bitter and warm. It enters spleen, lung, heart and kidney meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote the production of body fluid and nourish blood, induce tranquilization and promote intelligence. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of both qi and blood, asthenia, palpitation, insomnia, sexual impotence, and cold womb.
Saffron (CROCI STIGMA): sweet and neutral. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, cooling blood, removing toxic substance, resolving stagnation, and tranquilizing mind. Can be used for treating amenorrhea, abdominal mass, puerperal blood stasis, toxic heat, speckle, melancholy, stuffiness, palpitation, and mania.
Example 1
The medicine of the embodiment is composed of the following raw materials in parts by weight: 5g of angelica, 3g of ligusticum wallichii, 3g of salvia miltiorrhiza, 1g of ginseng and 1g of saffron, sufficient five traditional Chinese medicines are respectively crushed and sieved by a No. six sieve (100 meshes) specified in every case in the 'Chinese pharmacopoeia' (one part) of 2020 year edition to obtain fine powder of each traditional Chinese medicine, and the fine powder is uniformly mixed.
Example 2
The medicine of the embodiment is composed of the following raw materials in parts by weight: 5g of angelica, 4g of ligusticum wallichii, 2g of salvia miltiorrhiza, 2g of ginseng and 2g of saffron, sufficient five traditional Chinese medicines are respectively crushed and sieved by a No. six sieve (100 meshes) specified in the every case of the 'Chinese pharmacopoeia' (one part) of 2020 edition to obtain fine powder of each traditional Chinese medicine, and the fine powder is uniformly mixed.
Example 3 clinical observation experiment of the present invention for treating plantar fasciitis
(1) General data
Patients meeting the standard of plantar keratitis inclusion are selected to be distributed to a treatment group and a control group from 3 months to 2022 months of 2020 to 3 months of the Nanjing Chinese medicine university subsidiary hospital (the traditional Chinese medicine hospital in Jiangsu province) and the Nanjing Chinese medicine and Western medicine combination hospital (the traditional Chinese medicine and Western medicine combination hospital in Jiangsu province) of the Nanjing Chinese medicine university subsidiary hospital meeting the standard of plantar keratitis inclusion, 55 patients in each group have 110 patients with the age of 30-60 years, and the general data comparison difference of 2 groups of patients has no statistical significance (P is more than 0.05), so that the diagnosis method has comparability. The mean age of the treatment group was 51.42 years, and the mean course of disease was 5.56 ± 1.96 months; the mean age of the control group was 52.61 years, and the mean course of disease was 5.35 ± 2.10 months.
(2) Diagnostic criteria
The diagnosis standard of plantar fasciitis is implemented according to the diagnosis curative effect standard of traditional Chinese medicine symptoms issued by the national traditional Chinese medicine administration in 1994: (1) the disease is slow in onset, can have a medical history of several days or even years, is mostly generated in people with fat constitution above middle-aged, and has a certain relation with the senile degenerative change; (2) complaints about plantar pain, which is aggravated when walking or standing, especially when walking on uneven roads; (3) the affected part is generally not red and swollen, localized tenderness exists at the tubercles on the inner edge of the sole, and thickening and edema of the plantar aponeurosis can be seen in B ultrasonic and Magnetic Resonance Imaging (MRI) examination.
(3) Inclusion criteria
Meets the above diagnostic criteria; agreeing to participate in the test, having good compliance and signing an informed consent; the age is 30-60 years old, and male and female are not limited.
(4) Exclusion criteria
(1) Women with gestational period, blood system diseases, serious internal diseases and diabetes with poor blood sugar control; (2) fracture, foot contusion, lower limb neuropathy, and lumbar vertebra disease; (3) continuously taking analgesic for more than 1 week; foot skin ulceration, inflammatory exudation; (4) incomplete clinical data due to incompatibilities among the trials, withdrawal or lost follow-up visits.
(5) Method of treatment
Treatment groups: the preparation method of the mixed powder comprises the following steps of preparing the mixed powder according to the method of the embodiment 1, putting 6 g of the mixed powder into a self-made cotton bag (the size is close to that of the heel part of an insole commonly used by a patient), sewing the prepared medicine bag to line the heel part of the insole, sewing and fixing the medicine bag at the heel part of the insole, putting the insole in a worn shoe, wearing the insole with the medicine bag for a normal life, or using the insole with the design of the replaceable medicine bag at the heel part, and replacing the medicine bag for 1 time every week.
Control group: aceclofenac tablet is taken orally, 0.1g each time, 2 times/day; the glucosamine hydrochloride capsule is orally taken 0.48mg each time and 3 times a day half an hour after meals.
The course of treatment is as follows: 7 days are 1 course of treatment, and 2 groups are treated for 4 courses of treatment continuously, and then the effect is observed.
(6) Observation of indexes
Pain scoring: subjective pain perception of subjects was measured using the international general pain Numerical Rating Scale (NRS). The pain is classified into 1 to 10 grades, the larger the number is, the more severe the pain is, 0 is no pain, 10 is severe pain, the corresponding pain degree is selected by the patient according to the self feeling, and the pain is classified as follows: mild pain is rated at 1-3, moderate pain is rated at 4-6, and severe pain is rated at 8-10. The observation time point is the pain level before treatment and after each treatment, when the patient starts walking 30 minutes after sitting.
The evaluation standard of curative effect is as follows: (1) and (3) clinical recovery: the symptoms of local swelling, pain and the like of the patient disappear, pain points on the soles disappear, and the normal function is recovered; (2) the effect is shown: the local swelling and pain are obviously relieved, the pain points on the soles are improved, and the walking is not difficult; (3) the method has the following advantages: the local swelling and pain are relieved, the pain points on the soles are improved to a certain extent, the pain is slightly relieved, and the walking is still difficult; (4) and (4) invalidation: there was no improvement before and after treatment. Total effective rate = (clinical recovery + significant effect + effective)) cases/total cases × 100%.
(7) Statistical method
The analysis is carried out by SPSS 24.0 statistical software, and the measurement data adopts the mean value plus or minus standard deviation
Showing that before and after treatment in groups, the matching t test is adopted, the independent sample t test is adopted for comparison among groups, and the counting data is X 2 Inspection of P<A difference of 0.05 is statistically significant.
(8) As a result, the
Pain scoring: subjects were scored according to the international universal pain numerical rating scale, with no statistical significance for differences in NRS scores in 2 groups of patients prior to treatment (P > 0.05); after treatment, patients in the treatment group and the control group had significant differences in pain scores, both significantly lower than before treatment (P < 0.01), and the NRS score after treatment was lower than that of the control group (P < 0.05). The detailed results are shown in Table 1.
TABLE 1 comparison of pain scores for plantar fasciitis in the treated and control groups: (
Minute)
Note: compared with the control group before the treatment, ★ is represented by P>0.05; compared with the treatment before the treatment, ▲ is represented by P<0.01; after the treatment, compared with the control group, ● represents P<0.05。
The clinical curative effect is as follows: after treatment, the total effective rate of a treatment group is 100.00 percent (55/55), the total effective rate of a control group is 74.55 percent (41/55), and the difference of 2 groups has statistical significance (P is less than 0.01); the clinical cure rate of the treatment group is obviously higher than that of the control group, and the results are detailed in table 2.
TABLE 2 comparison of therapeutic effects of plantar fasciitis in the treatment group and the control group [ cases (%) ]
Note: compared with the control group, the compound of the formula, ★ represents P<0.01。
EXAMPLE 4 typical cases
(1) Liu Zhi, female, age 46, pain in heel of left side for 6 months, aggravated for 1 month. The pain feeling of the left heel in the morning is obvious without obvious inducement before half a year, the pain is intermittently attacked, the pressure pain point is usually near the heel of the foot, the pressure pain point is aggravated after activity, and the rest can be relieved. Pain worsens before one month and attacks are frequent. The pain is obviously relieved after the heel of the insole is sewn by the medicine bag of the formula of the embodiment 1, the medicine bag is replaced for 1 time every 7 days and is continuously used for 4 weeks, the pain symptom disappears, the insole is normal, and the heel of the insole is not relapsed after half a year follow-up visit.
(2) Li Shi, male 54 years old, right heel pain for 4 months, aggravated for half a month. In the area without obvious inducement before 4 months, the right heel has obvious stabbing pain feeling in the morning and intermittent pain, the pressure pain point is usually near the heel of the sole, the stabbing pain frequency is increased after activities, and the pain can be relieved after rest. The tenderness is more severe before half a month and persists, the pulsive and stabbing body feelings are obvious, and even the people have pain when standing for rest. The pain is obviously relieved after the heel of the insole is sewn by the medicine bag of the formula of the embodiment 1, the medicine bag is replaced for 1 time every 7 days and is continuously used for 4 weeks, the pain symptom disappears, the insole is normal, and the heel of the insole is not relapsed after half a year follow-up visit.
(3) Zhangiao, female, age 48, right heel pain for 3 months, aggravated for 1 week. Due to the working reason, when the high-heeled shoes are worn for a long time, the right heel part feels stabbing pain once when the high-heeled shoes stand for rest before 3 months, then the right heel part feels stabbing pain after morning rising and long-time walking, the frequency is increased, and the high-heeled shoes are improved after rest. The pain is aggravated and the frequency is increased before 1 week, and the tenderness is more severe, which affects the normal work. The pain is obviously relieved after the medicine bag is sewn at the heel part of the insole by using the medicine bag of the formula of the embodiment 1 for 1 week, the medicine bag is replaced for 1 time every 7 days and is continuously used for 4 weeks, the pain symptom disappears and is recovered to be normal, the patient is instructed to pay attention to shorten the walking time when wearing the high-heeled shoes at ordinary times after being healed, and the follow-up visit is not repeated after half a year.
Claims (4)
1. A traditional Chinese medicine composition for treating plantar fasciitis is characterized by being prepared from the following raw medicines in parts by weight: 4-6 parts of angelica, 2-4 parts of ligusticum wallichii, 2-4 parts of salvia miltiorrhiza, 1-2 parts of ginseng and 1-2 parts of saffron.
2. The traditional Chinese medicine composition for treating plantar fasciitis according to claim 1, which is prepared from the following raw medicines in parts by weight: 5 parts of angelica, 3 parts of ligusticum wallichii, 3 parts of salvia miltiorrhiza, 1 part of ginseng and 1 part of saffron.
3. The traditional Chinese medicine composition for treating plantar fasciitis according to claim 1 or 2, which is prepared by respectively crushing five raw material medicines into fine powder and uniformly mixing the fine powder according to a ratio.
4. The traditional Chinese medicine composition for treating plantar fasciitis as claimed in claim 3, wherein the fine powder conforms to a No. six sieve (100 meshes) specified in all cases of the "Chinese pharmacopoeia" (one) of 2020 edition.
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