CN101474361B - Chinese medicine for treating cerebropathy - Google Patents

Chinese medicine for treating cerebropathy Download PDF

Info

Publication number
CN101474361B
CN101474361B CN200910064100XA CN200910064100A CN101474361B CN 101474361 B CN101474361 B CN 101474361B CN 200910064100X A CN200910064100X A CN 200910064100XA CN 200910064100 A CN200910064100 A CN 200910064100A CN 101474361 B CN101474361 B CN 101474361B
Authority
CN
China
Prior art keywords
radix
medicine
starch
poria
rehmanniae preparata
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200910064100XA
Other languages
Chinese (zh)
Other versions
CN101474361A (en
Inventor
蔡俊安
郭鑫慧
王粉
张洪涛
张祥俊
何丽果
刘振华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HENAN BAINIAN KANGXIN PHARMA CO Ltd
Original Assignee
HENAN BAINIAN KANGXIN PHARMA CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HENAN BAINIAN KANGXIN PHARMA CO Ltd filed Critical HENAN BAINIAN KANGXIN PHARMA CO Ltd
Priority to CN200910064100XA priority Critical patent/CN101474361B/en
Publication of CN101474361A publication Critical patent/CN101474361A/en
Application granted granted Critical
Publication of CN101474361B publication Critical patent/CN101474361B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The invention relates to a Chinese medicine for the treatment of encephalopathy, which is effective for the treatment of the encephalopathy, the method thereof comprises the steps as follows: taking 65-75g of prepared rhizome of rehmannia, 65-75g of cornus officinalis, 80-100g of cistanche salsa, 80-100g of morinda officinalis, 18-22g of cinnamomum zeylanicum, 45-55g of dwarf lilyturf root, 65-75g of dendrobium nobile, 35-45g of fructus schizandrae, 35-45g of rhizome acori tatarinowii, 35-45g of polygala tenuifolia, 45-55g of poria cocos, 45-55g of rhizoma ligustici wallichii, 65-75g of achyranthes bidentata, 55-65g of root of kudzu vine, starch, dextrine and magnesium stearate as raw materials, baking the cornus officinalis and the root of kudzu vine, drying the cinnamomum zeylanicum, mixing and crushing the three for backup; then adding water to the rest eleven drugs for decoction twice, extraction, filtration, filtrates combination, reduced pressure concentration and mixing with the drug powders made of cornus officinalis, root of kudzu vine and cinnamomum zeylanicum, baking, crushing and adding the starch and dextrine into the mixture for mixing, followed by spraying ethanol while spraying, granulating after the uniform spraying, drying, adding the starch and the magnesium stearate, after the uniform mixing, preparing tablets and sugar-coating to obtain the medicine; the invention is effective for various brain diseases as well as has rapid effective time and up to 96% of effective percentage, bringing great benefits to mankind.

Description

A kind of Chinese medicine for the treatment of Research of Senile Dementia Treated and cerebral infarction
One, technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine (claiming to return first brain-strengthening sheet again) for the treatment of encephalopathy.
Two, technical background
Over the past thousands of years, encephalopathy is the formidable enemy of human health always, it also is a world medicine difficult problem, according to investigations, encephalopathy and Cranial nerve injury as birth trauma disease account for about 30% of human diseases sum, the investigation statistics of being done in 2004 according to China hygiene department shows: China encephalopathy patient accounts for 6.06% of national population, be about 8,000 ten thousand people at present, according to professional person statistics, the market demand total amount of relevant encephalopathy treatment and rehabilitation is above 20,000,000,000 yuans, what is more important, no matter international or domestic in recent years, the progress of encephalopathy medicine is quite slow, and the morbidity cumulative year after year of encephalopathy, the supply of related drugs can not be met the need of market far away.China is populous nation, the huge population base and the high incidence of encephalopathy directly cause China annual encephalopathy New Development patient in necessarily situation, but about the preventing and controlling of encephalopathy and the level of preventing and treating backward unusually, so far there are not effective treatment means and method, the encephalopathy patient of the overwhelming majority can only stay at home and be taken care of by the special messenger, cause great burden for family and society, develop a kind of medicine of effective treatment encephalopathy so?
Three, summary of the invention
At above-mentioned situation, the present invention's purpose just provides a kind of Chinese medicine for the treatment of encephalopathy, can be effective to treat encephalopathy, the technical scheme of its solution is, Chinese medicine of the present invention adopts by Radix Rehmanniae Preparata 65-75g, Fructus Corni 65-75g, Herba Cistanches 80-100g, Radix Morindae Officinalis 80-100g, Cortex Cinnamomi 18-22g, Radix Ophiopogonis 45-55g, Herba Dendrobii 65-75g, Fructus Schisandrae Chinensis 35-45g, Rhizoma Acori Graminei 35-45g, Radix Polygalae 35-45g, Poria 45-55g, Rhizoma Chuanxiong 45-55g, Radix Achyranthis Bidentatae 65-75g, Radix Puerariae 55-65g makes material medicine and starch, dextrin, magnesium stearate is made as ancillary drug, wherein, in the preparation, earlier with Fructus Corni, Radix Puerariae is cleaned, oven dry, Cortex Cinnamomi is cleaned cold drying, three flavor medicine mix homogeneously then, crushing screening gets medicated powder, and is standby; Again with Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae add its ten simply the medicine bulking value and 10-6 decocting doubly boil twice, extracted 2-1 hour, filter, merging filtrate, be evaporated under 80 ℃~90 ℃, relative density is 1.35~1.40 thick paste, with Fructus Corni, standby medicated powder that Radix Puerariae and Cortex Cinnamomi are made and thick paste mix homogeneously, 70 ℃~80 ℃ oven dry down, be ground into fine powder, add the starch of this fine powder weight 5% and 5% dextrin again and mix, spray mass concentration while stirring and be 75% ethanol, granulate in the even back of spray, 80 ℃ of oven dry get base material, add the starch of this base material weight 5% and 0.5% magnesium stearate again, behind the mixing, make sheet, sugar coating, promptly, bulking value is meant solid (medicine) with g meter, and liquid (water) is with the ml meter, and is as follows.
The present invention is effective to various brain diseasess such as brain atrophy, brain dementia, cerebral palsy, cerebral dysgenesis, mental retardation, retarded, apoplexy sequela (hemiplegia, aphasia), Parkinson's disease, and the treatment of series function obstacle such as the intelligence that causes by encephalopathy, memory, language, motion, responding time is fast, medication turn-head-rate height, effective percentage reaches 96%, be that one on the Chinese medicine and pharmacy innovated greatly, bring benefit to the mankind.
Four, the specific embodiment
Below in conjunction with practical situation the specific embodiment of the present invention is elaborated.
Provide by technique scheme, the present invention in the specific implementation, by Radix Rehmanniae Preparata 65-75g, Fructus Corni 65-75g, Herba Cistanches 80-100g, Radix Morindae Officinalis 80-100g, Cortex Cinnamomi 18-22g, Radix Ophiopogonis 45-55g, Herba Dendrobii 65-75g, Fructus Schisandrae Chinensis 35-45g, Rhizoma Acori Graminei 35-45g, Radix Polygalae 35-45g, Poria 45-55g, Rhizoma Chuanxiong 45-55g, Radix Achyranthis Bidentatae 65-75g, Radix Puerariae 55-65g makes material medicine and starch, dextrin, magnesium stearate is made as adjuvant, wherein, in the preparation, earlier with Fructus Corni, Radix Puerariae is cleaned oven dry, Cortex Cinnamomi is cleaned cold drying, three flavor medicine mix homogeneously then, pulverized sieve No. 5, get medicated powder, standby, again with Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae ten medicine simply decocts with water twice, add for the first time Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water of 10 times of amounts, extracted 2 hours, medicinal residues are added and are stated Radix Rehmanniae Preparata for the second time, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water of 6 times of amounts, extracted 1 hour, filter, merge filtrate twice, be evaporated under 80 ℃~90 ℃, relative density is 1.35~1.40 thick paste, with above Fructus Corni, standby medicated powder that Radix Puerariae and Cortex Cinnamomi are made and thick paste mix homogeneously, 70 ℃~80 ℃ oven dry down, be ground into fine powder, adding the starch of this fine powder weight 5% and 5% dextrin again mixes, spray mass concentration while stirring and be 75% ethanol, granulate in the even back of spray, 80 ℃ of oven dry, get base material, add the starch of base material weight 5% and 0.5% magnesium stearate again, behind the mixing, compacting in flakes, sugar coating, that is every heavy 0.5g.
The present invention in the specific implementation, also can be by Radix Rehmanniae Preparata 70g, Fructus Corni 70g, Herba Cistanches 90g, Radix Morindae Officinalis 90g, Cortex Cinnamomi 20g, Radix Ophiopogonis 50g, Herba Dendrobii 70g, Fructus Schisandrae Chinensis 40g, Rhizoma Acori Graminei 40g, Radix Polygalae 40g, Poria 50g, Rhizoma Chuanxiong 50g, Radix Achyranthis Bidentatae 70g, Radix Puerariae 60g makes material medicine and starch, dextrin, magnesium stearate is made as adjuvant, wherein, in the preparation, earlier with Fructus Corni, Radix Puerariae is cleaned oven dry, Cortex Cinnamomi is cleaned cold drying, three flavor medicine mix homogeneously then, pulverized sieve No. 5, get medicated powder, standby, again with Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae ten medicine simply decocts with water twice, add for the first time above-mentioned Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water 6600ml of 10 times of amounts, extracted 2 hours, filter, get filtrate, in medicinal residues, add for the second time Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water 3960ml of 6 times of amounts, extracted 1 hour, filter, merge filtrate twice, be evaporated under 85 ℃, relative density is 1.40 thick paste, will be by Fructus Corni, Radix Puerariae, standby medicated powder that Cortex Cinnamomi is made and thick paste mix homogeneously, 75 ℃ of oven dry down, be ground into fine powder, adding the starch of this fine powder gross weight 5% and 5% dextrin again mixes, spray mass concentration while stirring and be 75% ethanol, granulate in the even back of spray, 80 ℃ of oven dry, get base material, add the starch of this base material weight 5% and 0.5% magnesium stearate again, behind the mixing, with the pelleter compacting in flakes, sugar coating, that is every heavy 0.5g.
In said medicine, wherein:
Radix Rehmanniae Preparata: clean, steam and boil in a covered pot over a slow fire, dry, section, property is sweet, tepor, YIN nourishing is enriched blood, and controls deficiency of YIN insufficiency of blood, the waist knee flaccidity, the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.
Fructus Corni: remove discarding stalk and fruit stem, cure, dry or dry, Ye Xianxin, big heat, invigorating the liver and kidney, arresting seminal emission gas, dizzy Gu soreness of waist and knee joint is controlled in collapse, tinnitus, sexual impotence, seminal emission, frequent micturition, the deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.
Herba Cistanches: choose clean impurity, run through, section is dried, and the sweet acid of property is salty, tepor, and the kidney invigorating, benefit is smart, moisturizes, and laxation is controlled impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.
Radix Morindae Officinalis: choose decontamination, cutting is dried, kidney-replenishing, and strengthening bone and muscle, wind-damp dispelling is controlled sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.
Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, with the eliminating cold for resuscitation water infiltration for a moment, acrid in the mouth is dried in section, temperature, complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation is controlled decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Radix Ophiopogonis: choose clean impurity, soak into, clean and dry, sweet in the mouth, flat, nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.
Herba Dendrobii: stewing profit, cutting is dried, and sweet in the mouth is flat, the stomach reinforcing that promotes the production of body fluid, clearing away heat and nourishing YIN is controlled consumption of body fluid caused by febrile disease, and dry mouth is thirsty, deficiency-heat after being ill, it is dark that the moon is hindered order.
Fructus Schisandrae Chinensis: well sifted ash bits, remove impurity, steam thoroughly, dry, sour in the mouth, temperature is astringed the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, and arresting seminal emission is controlled the deficiency of the lung and is breathed heavily, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Rhizoma Acori Graminei: choose decontamination, clean, soak, run through, section is dried, and the acrid in the mouth hardship is had one's ideas straightened out, and eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and the wind that looses dries, and controls syncope due to accumulation of phlegm, and the calentura coma is forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Radix Polygalae: choose decontamination, cutting, sieve dedust bits, bitter in the mouth, temperature, the Fructus Alpiniae Oxyphyllae of calming the nerves is eliminated the phlegm, and resolving depression is controlled palpitation with fear, and is forgetful, nocturnal emission, insomnia, cough ant phlegm, the carbuncle skin ulcer is swollen.
Poria: soak, clean, pull out, vexed, section is dried, and sweet in the mouth is flat, eliminating dampness and diuresis, and the strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming is controlled dysuria, edema distension, the expectorant cough with dyspnea of cooking a meal, the sound of vomiting of vomitting is had loose bowels, and passes out semen, and stranguria with turbid discharge is palpitated with fear, and is forgetful.
Rhizoma Chuanxiong: choose decontamination, soak, solarization is dried in the air, moistening, and section, drying, acrid in the mouth, temperature, activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.
Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried, and bitter in the mouth acid is flat, gives birth to and use dissipating blood stasis blood, and subduing inflammation is controlled gonorrhea, hematuria, and amenorrhea is had difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury.
Radix Puerariae: choose decontamination, clean, soak, pull out, run through, section is dried, and sweet in the mouth is flat, the yang invigorating expelling pathogenic factors from muscles, and rash antidiarrheal, relieving restlessness is quenched the thirst, and it is cold to cure the wound, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, and dysentery, skin eruption are not saturating, hypertension, angina pectoris, deafness.
By above-mentioned all medicine compatibilities as can be known, the present invention has liver and kidney tonifying, nourishing the brain and improving intelligence, be applicable to that deficiency of the liver and kindey disease sees that hypomnesis, mental retardation, dizziness and tinnitus, soreness of the waist and knees, tired lazy think of crouch, look slow-witted blunt, pale tongue with thin fur white, deep,thready and forceless pulse, be effective to the treatment of encephalopathy, and, obtained good result through clinical practice, its interrelated data is as follows:
One, selects the standard of case
Research of Senile Dementia Treated and cerebral infarction belong to disease common in the encephalopathy, Research of Senile Dementia Treated and essence and blood lose empty, deficiency of marrow-reservoir, and the phlegm stagnancy blood stasis is closely related, void is the reason that produces the stasis of blood, the stasis of blood increases the weight of void conversely again, and brain can not get essence and blood and brings up, and simultaneously again can not be in time himself metabolite be excluded, more increase the weight of damage, look slow-witted blunt, mental retardation, and life can't be taken care of oneself.
Cerebral infarction is a kind of systemic disease, and its main diseases gradually causes visceral dysfunctions such as the heart, liver,spleen,kidney because of excessive, the stasis of blood, expectorant, strongly fragrant outward, insufficiency of vital energy and blood, and it is withered that kidney essense declines, and yang deficiency expectorant accumulates, caused by energy stagnation and blood stasis.Its sick position is at brain, and it is its pathologic basis that the brains mistake is filled; And the imbalance of heart kidney, the essence and blood loss, the expectorant stasis of blood is covered and is closed, and refreshing the stagnating of Naokong then is basic pathogenesis.
Two, diagnostic criteria
The diagnostic criteria of Research of Senile Dementia Treated is: memory obviously goes down, and easily lost, it is very difficult to wear the clothes, or trousers is pledged clothes wear; Be not familiar with friend or relatives' looks, forget their name yet, can not talk with others, to murmur to oneself sometimes, aphasia, apraxia, agnosia, personality changes can not be explained by any non-organic mental sickness.
The diagnostic criteria of cerebral infarction is: show as neurasthenia's phase in early days 1.: the patient often tells that dizziness, headache, attention and memory, computing power, orientation force are gradual and go down, insomnia, drowsiness, brothers are numb etc.; 2. mid-term: based on dysmnesia and affective disorder, show as memory difficulty when near, particularly to name, numeral can not be remembered, even the same day, institute's dietetic variety was not all remembered clearly, because recent memory power descends, the thing of process seems specious at ordinary times, remember inentirely,, upbraided as " lying " sometimes by the household because of often fabricating unconsciously, and personality, memory or judgement, reasoning, function and insight such as calculating still can remain intact in considerable time, patient's emotional instability, emotional, susceptible to get angry is easily cried, and spirit depressing or delirium are often with anxiety, gloom or animosity etc.; 3. late period: disturbance of intelligence occurs.Because the outbreak repeatedly of apoplexy, intelligence obviously goes down, forced weeping and laughing, or apathy, orientation force, faculty of understanding, computing power serious hindrance go down to thing far away and short term memory ability gradually, even can not remember oneself age, year of birth, trot out, later then fail to see the door.
Three, therapeutic scheme
The oral the present invention of patient, one time 5,3 times on the one, every heavy 0.5g, be a course of treatment January, 3 courses of treatment of every clothes, the statistics effect, period in a medicine is stopped using, and other expands blood vessel, improves the blood circulation medicine.
Four, efficacy assessment standard
Cure: cardinal symptom is recovered normally substantially, and is directed sound, and it is correct to answer a question, and takes care of oneself, and can recover general Du can be movable;
Produce effects: cardinal symptom is most of recovers normal, and orientation is sound substantially, and answering a question is in the main true, and reaction is general, and life can be taken care of oneself;
Effectively: main mental symptom alleviates to some extent or part is lost slightly, and life is taken care of oneself substantially, and answering a question is in the main true, but bradykinesia, intelligence and personality still have obstacle;
Invalid: cardinal symptom does not have change even continues development.
Five, statistical disposition
Take Drug therapy Research of Senile Dementia Treated 100 routine observation of curative effect of the present invention:
1, clinical data
100 examples are organized in treatment, male's 73 examples wherein, and women's 27 examples, the oldest 78 years old, minimum 50 years old, 64 ± 5 years old mean age, the course of disease is the longest 11 years, and was the shortest 6 months, average 2 years.
Matched group 30 examples, male's 20 examples wherein, women's 10 examples, the oldest 77 years old, minimum 50 years old, the mean age was 64 ± 5 years old, the course of disease is the longest 10 years, and is the shortest 6 months, average 2 years.
2, case is selected
2.1 tcm diagnosis standard and Chinese medical discrimination belong to deficiency of marrow-reservoir card (developing the standard that can formulate with reference to whole nation association of traditional Chinese medicine gerontology meeting in May nineteen ninety senile dementia special topic science).
2,2 Western medicine diagnose standards (with reference to the nineteen eighty-three DSM-IV of American Psychiatric Association standard)
3, test method
The treatment group is taken medicine of the present invention, and oral every day 3 times, each 5, matched group is taken anti senile (Longshan Pharmaceutical Factory produce, 0.3g * 60), and every day 3 times, each 5, two medicines were 1 course of treatment with 1 month all, evaluates curative effect after observing 1 course of treatment.
4, curative effect determinate standard (before week)
Clinic control: cardinal symptom is recovered normally substantially, and is directed sound, and it is correct to answer a question, and takes care of oneself, and can recover the mass society activity; Produce effects: cardinal symptom is most of recovers normal, and orientation is sound substantially, and answering a question is in the main true, and reaction is general, and life can be taken care of oneself; Effectively: main mental symptom alleviates to some extent or part disappears, and life is taken care of oneself substantially, and answering a question is in the main true, but bradykinesia, intelligence and personality still have obstacle; Invalid: cardinal symptom does not have change even continues development.
5, result
5.1 treatment group clinic control 8 examples, produce effects 27 examples, effective 61 examples, invalid 4 examples, total effective rate 96.00%, matched group are respectively clinic control 2 examples, produce effects 7 examples, effective 15 examples, invalid 6 examples, total effective rate 80%; The treatment group is better than matched group.
5.2 the present invention can improve the SOD enzymatic activity, and blood plasma LPO content is reduced, treatment group treatment back SOD, LPO improve obviously significant difference (P<0.05, P<0.01) (seeing the following form)
LPO changes of contents in erythrocyte sod enzymatic activity and the blood plasma before and after the medication
*P<0.05 **P<0.01
5.3T-ch there were significant differences (P<0.05) before and after the treatment of treatment group; Make moderate progress after HDL-ch, the treatment of LDL-ch treatment group.
5,4 the present invention can improve patient's hemorheology level; The hemorheology level has obvious change (P<0.01) before and after the medication of treatment group, and treatment back treatment group is compared the variation of hemorheology, and there were significant differences (P<0.05) with matched group, illustrates that treatment group curative effect is better than matched group.
5.5 the present invention also can make most clinical symptoms be improved or alleviate, symptom integral has highly significant difference (P<0.01) before and after the treatment of treatment group.
6 conclusions
6.1 Research of Senile Dementia Treated and essence and blood lose empty, deficiency of marrow-reservoir, the phlegm stagnancy blood stasis is closely related, and void is the reason that produces the stasis of blood, and the stasis of blood increases the weight of void conversely again, brain can not get essence and blood and brings up, simultaneously again can not be in time himself metabolite be excluded, more increase the weight of to damage, reinforce insufficiency and reduce excessiveness must start at the same time, medicine of the present invention has the merit of nourishing kidney-yin, kidney-replenishing, inducing resuscitation and resolving phlegm, confirms that by clinical observation medicine of the present invention is significantly improved to motion, consciousness sensory disturbance and subjective symptoms.Symptom integral obviously reduces before and after the treatment of treatment group, and total effective rate is 96%.
6.2 the present invention can obviously reduce serum T-ch, LDL-ch, improves HDL-ch and SOD enzymatic activity, and blood plasma LPO content is reduced, and improves the hemorheology level.Point out this medicine can remove free radical, suppress that lipofuscin forms and accumulation, atherosclerosis, this with take medicine that the back blood stasis goes, expectorant is turbid clearly, mechanism that healthy energy is multiple is consistent.
Take Drug therapy cerebral infarction 30 routine clinical observations of the present invention:
1, physical data
This organizes 30 examples, male 17 examples, women 13 examples; The oldest 71 years old, minimum 45 years old, average 55.5 years old, the course of disease was the longest 3 years, and was the shortest 3 months, average 1.8 years.Blocking part: basal ganglia region 14 examples, temporal lobe 5 examples, frontal lobe 2 examples, other 1 example of the ventricles of the brain, multiple cerebral infarction 5 examples; Merge disease: hypertension 15 examples, coronary heart disease 5 examples, cerebral arteriosclerosis 8 examples, diabetes 2 examples, this group case all is diagnosed as Cerebral Infarction Patients through computed tomography brain scan.
2, Therapeutic Method
The oral medicine of the present invention of patient, each 5, every day 3 times, be a course of treatment January, 3 courses of treatment of every clothes, the statistics effect, period in a medicine is stopped using, and other expand blood vessels, improve the blood circulation medicine.
3, observation item
1. clinical symptoms: headache, dizziness, limb function, language function, comprehensive function adopts the score of classification scoring method respectively.
2. experimental index: hemorheological indexes: comprise whole blood contrast viscosity, plasma viscosity, erythrocyte electrophoresis, packed cell volume, fibrinuria, erythrocyte sedimentation rate etc.
4, criterion of therapeutical effect
" apoplexy " disease criterion of therapeutical effect according to State Administration of Traditional Chinese Medicine's issue in 1994 is worked out.Cure: symptom and sign disappear, and can live on one's own life substantially; Take a turn for the better: symptom and sign take a turn for the better, can the cane action or take care of oneself substantially; Do not heal: symptom and sign no change.
5, result
This group patient 30 examples are cured 11 examples, account for 36.7%, and 16 examples that take a turn for the better account for 53.7%, and 3 examples that do not heal account for 10%, total effective rate 90%.
Cerebral infarction is a kind of systemic disease, and its main diseases gradually causes visceral dysfunctions such as the heart, liver,spleen,kidney because of outer " excessive, the stasis of blood, expectorant, strongly fragrant ", insufficiency of vital energy and blood, and it is withered that kidney essense declines, and yang deficiency expectorant accumulates, caused by energy stagnation and blood stasis.Its sick position is at brain, and it is its pathologic basis that the brains mistake is filled; And the imbalance of heart kidney, the essence and blood loss, the expectorant stasis of blood is covered and is closed, and refreshing the stagnating of Naokong then is basic pathogenesis.The present invention treats the merit that cerebral infarction has replenishing essence the kidney invigorating, eliminate stagnation and dissolve phlegm, nourishing the brain and improving intelligence.To tinnitus, dizziness, dull expression due to senile disease deficiency of kidney-essence, the deficiency of marrow-reservoir, hypomnesis etc. all have curative effect preferably, and have no side effect.
Curative effect of medication height of the present invention about 90%, reaches 95% to the improvement rate of headache to the improvement rate of cardinal symptom, sign, and aphasia improvement rate is reached 100%.The variation of hemorheology index and curative effect: the whole blood viscosity height was cut before this organized 30 routine patient treatments, low cutting, plasma viscosity, erythrocyte electrophoretic time, erythrocyte sedimentation rate, Fibrinogen all is significantly higher than normal group, and significantly the increasing of viscosity, aggregation and coagulability that this shows visible component in the blood is the hematodinamics and the pathophysiology basis of cerebral infarction morbidity.After taking medicine of the present invention, the hemorheology index of all observations all be improved significantly, this is that the effect of blood circulation promoting and blood stasis dispelling of the present invention embodies, and has preferably viscosity reduction, goes effects such as fibre, anticoagulant, depolymerization, be the active drug of cerebral infarction therapy, utilization is worthy to be popularized.
And through animal experiment, increase the intelligence effect and study of the present invention, data is as follows:
1, the animal mice is the Kunming kind, and effluent south medical university animal center provides.
2, experimental technique and result
The scopolamine induced mice is remembered the influence (diving tower method) of acquired obstacle:
Get 50 of two mices of forelimb sole skin resistance between 150~200K Ω, male and female half and half, evenly be divided into 5 groups at random, wherein make dysmnesia model for 4 groups, the modeling type gavages the first brain-strengthening suspendible of returning of large and small dosage respectively for 4 groups and crosses, the piracetam suspendible crosses and with the normal saline of volume, 1 group of not administration is as the blank group in addition.Each organizes administration every day 1 time, successive administration 7 days, after irritating stomach in the 6th day 1 hour, 4 groups on modeling type, the scopolamine of every Mus lumbar injection 5mg/Kg, blank group lumbar injection after 10 minutes are put into mice the capsule of diving tower instrument and are trained with the normal saline of volume, allow mice diving tower instrument capsule endoadaptation 3 minutes during training earlier, connect the 36V electric current again.Animal is shocked by electricity, normal reaction is to hide electric shock on the rebound diving tower, the mice biped contacts the copper grid simultaneously for getting an electric shock, be considered as wrong reaction, trained 5 minutes, the 7th day (after 24 hours) are irritated behind the stomach and mice to be put into the diving tower instrument in 1 hour and test again, observe the mouse memory situation, the record mice is errors number in the incubation period and 5 minutes that diving tower jumps off first, the results are shown in Table 1.
Table 1 returns first brain-strengthening sheet to the influence of the acquired obstacle of mouse memory (X ± SD)
Figure G200910064100XD00091
Figure G200910064100XD00101
* represent with model group than P>0.05, * * represent with model group than P<0.05, * * * represent with model group than P<0.01 (following table with)
Can find out and blank group ratio that from last table model group can obviously reduce hide (P<0.01) that mice jumps off first, significantly increases errors number in 5 minutes (P<0.05), illustrate and make the dysmnesia model success.With the model group ratio, heavy dose return first brain-strengthening sheet group can obviously prolong the incubation period (P<0.01) that mice jumps off first and obviously reduce 5 minutes in errors number (P<0.01), but low dose is returned incubation period (P<0.05) that first brain-strengthening group and piracetam group significant prolongation mice jump off and remarkable errors number (P<0.05) in the minimizing 5 minutes.
2.2 influence (diving tower method) to sodium nitrite induced mice memory steadiness obstacle:
Get 50 of two mices of forelimb sole skin resistance between 150~300K Ω, male and female half and half, grouping and administration are all the same.After irritating stomach in the 6th day 1 hour, mice is put respectively to the little basin of diving tower instrument, adapts to 3 minutes, logical 36V electric current was trained 5 minutes, and mice is taken out lumbar injection sodium nitrite 120mg/Kg immediately, and its empty group is injected the normal saline with volume.Again tested the mouse memory situation in 1 hour behind the 7th day (24 hours) filling stomach, errors number in incubation period and 5 minutes that observation and record mice jump off first the results are shown in Table 2.
Table 2 returns first brain-strengthening sheet mouse memory to be consolidated the influence (X ± SD) of obstacle
Figure G200910064100XD00102
Can find out and blank group ratio that from table 2 model group can obviously reduce the incubation period (P<0.01) that mice jumps off first, significantly increases errors number in 5 minutes (P<0.01), illustrate and make the dysmnesia model success.With the model group ratio, heavy dose returns first brain-strengthening group and piracetam group that sodium nitrite induced mice memory is consolidated obviously to prolong incubation period that the obstacle model mice jumps off first (P<0.01), make that errors number obviously reduces in 5 minutes (P<0.01), but low dose return the incubation period (P<0.05) that first brain-strengthening group significant prolongation mice jumps off first and significantly reduce 5 minutes in errors number.
2.3 the scopolamine induced mice is remembered the influence (darkness avoidance test) of acquired obstacle
Get two mices of forelimb sole resistance between 150~300K Ω, earlier mice is put into darkness avoidance test during experiment and measure box, no power selects 50 of mices that enter the darkroom in 40 seconds, and male and female half and half evenly are divided into 5 groups at random, and it is the same that each organizes perfusion.Irritated stomach on the 6th day after 1 hour, 4 groups on modeling type, every Mus lumbar injection scopolamine 5mg/kg, blank group lumbar injection gives scopolamine after 10 minutes with the normal saline of volume, mouse tail is put into facing to the osculum that enters the darkroom measured box, connect the 36V power supply. trained 5 minutes, the 7th day (after 24 hours) are irritated stomach and are redeterminated mouse memory power after 1 hour, observe and the record mice enters first in incubation period and 5 minutes in darkroom and enters the number of times that is shocked by electricity in the darkroom, the results are shown in Table 3.
Table 3 is returned the influence of first brain-strengthening sheet to the acquired obstacle of mouse memory: (X ± SD)
Figure G200910064100XD00111
Can find out and blank group ratio that from table 3 model group can obviously reduce the incubation period (P<0.01) that mice jumps off first, obviously increases errors number in 5 minutes (P<0.01), illustrate and make the dysmnesia model success.With the model group ratio, heavy dose return first brain-strengthening group and piracetam group all can obviously prolong the incubation period (P<0.01) that mice enters the darkroom first and obviously reduce 5 minutes in errors number (P<0.01), low dose returns first brain-strengthening group can obviously reduce errors number in 5 minutes (P<0.01), has certain prolongation mice to enter the preclinical effect in darkroom.
2.4 the influence (darkness avoidance test) that obstacle is consolidated in memory to the sodium nitrite induced mice
Get the mice between two forelimb sole resistance, 150~300K Ω, during experiment mice is put into the darkness avoidance test analyzer, no power selects 50 of mices that entered the darkroom in 40 seconds, and male and female half and half evenly are divided into 5 groups at random, and perfusion is the same.After irritating stomach in the 6th day 1 hour, mouse tail is put into the mensuration box facing to the osculum that enters the darkroom, connect the 36V power supply, trained 5 minutes, training back model is injected sodium nitrite 120mg/Kg to mouse peritoneal for 4 groups immediately, and blank group lumbar injection is with the normal saline of volume, irritated behind the stomach 1 hour the 7th day (after 24 hours), again test the mouse memory situation, observe and the record mice enters errors number in incubation period and 5 minutes in darkroom first, the results are shown in Table 4.
Table 4 is returned the influence of first brain-strengthening sheet to mouse memory steadiness obstacle
Can find out and blank group ratio that from last table errors number (P<0.01) in model group can obviously reduce the incubation period (P<0.01) that mice enters the darkroom first and obviously increase by 5 minutes illustrate and makes mouse memory obstacle model successfully.With the model group ratio. obviously prolong (P<0.01) incubation period that heavy dose returns first brain-strengthening group and piracetam group all can make memory steadiness obstacle model mice due to the sodium nitrite enter the darkroom first and make that errors number obviously reduces in 5 minutes (P<0.01), low dose returns first brain-strengthening group to the incubation period that the memory steadiness obstacle mice due to the sodium nitrite enters the darkroom first prolongation trend being arranged, and makes that errors number has minimizing trend in 5 minutes.
3, discuss
One of main clinical manifestation of Research of Senile Dementia Treated is hypophrenia, past attempts thinks that Research of Senile Dementia Treated is irreversible, think that now medicable dementia accounts for 20~30% of diagnosed SARS case, and can be clearly better after 20~40% patient's behavior and the nervous symptoms treatment, especially vascular dementia.The traditional Chinese medical science thinks that the pathogenesis of Research of Senile Dementia Treated is a deficiency of kidney-essence, deficiency of marrow-reservoir, and the mind usefulness of giving up, the rule of treatment are mended essence and are filled marrow.The present invention is by the replenishing essence the kidney invigorating, eliminate stagnation and dissolve phlegm and reach the merit of nourishing the brain and improving intelligence.Modern study thinks that memory and brain aging, brain protein synthesis, cerebral circulation, cholinergic nerve of centrum etc. are closely related.
Six, conclusion
In sum, experimental results show that in the prescription of the present invention that Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Corni, Herba Cistanches, Fructus Schisandrae Chinensis have inhibitory action to rat cerebral even slurry lipid peroxide (LPO) more than the warp; Herba Cistanches, Radix Rehmanniae Preparata, Radix Ophiopogonis can promote protein, nucleic acid metabolism, and Rhizoma Acori Graminei, Radix Polygalae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the useful painstaking effort of Radix Achyranthis Bidentatae and sharp blood vessels effect can cardiac function enhancings, strengthen corticocerebral ability to work; Rhizoma Chuanxiong, Radix Puerariae have tangible promotion and protective effect to the learning and memory of little mouse process, and the preventive and therapeutic effect that the present invention obtains memory and the obstacle model is consolidated in memory promptly is that the comprehensive function by above all medicines realizes.The present invention improves the effect of ability of learning and memory, and also it can treat one of mechanism of Research of Senile Dementia Treated just.

Claims (2)

1. Chinese medicine for the treatment of Research of Senile Dementia Treated and cerebral infarction, it is characterized in that, by Radix Rehmanniae Preparata 65-75g, Fructus Corni 65-75g, Herba Cistanches 80-100g, Radix Morindae Officinalis 80-100g, Cortex Cinnamomi 18-22g, Radix Ophiopogonis 45-55g, Herba Dendrobii 65-75g, Fructus Schisandrae Chinensis 35-45g, Rhizoma Acori Graminei 35-45g, Radix Polygalae 35-45g, Poria 45-55g, Rhizoma Chuanxiong 45-55g, Radix Achyranthis Bidentatae 65-75g, Radix Puerariae 55-65g makes material medicine and starch, dextrin, magnesium stearate is made as ancillary drug, wherein, in the preparation, earlier with Fructus Corni, Radix Puerariae is cleaned, oven dry, Cortex Cinnamomi is cleaned cold drying, three flavor medicine mix homogeneously then, crushing screening gets medicated powder, and is standby; Again with Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae add its ten simply the medicine bulking value and 10-6 decocting doubly boil twice, extracted 2-1 hour, filter, merging filtrate, be evaporated under 80 ℃~90 ℃, relative density is 1.35~1.40 thick paste, with Fructus Corni, standby medicated powder that Radix Puerariae and Cortex Cinnamomi are made and thick paste mix homogeneously 70 ℃~80 ℃ oven dry down, are ground into fine powder, adding the starch of this fine powder weight 5% and 5% dextrin again mixes, spray mass concentration while stirring and be 75% ethanol, 80 ℃ of oven dry are granulated in the even back of spray, get base material, add the starch of this base material weight 5% and magnesium stearate O.5% again, behind the mixing, film-making, sugar coating, promptly.
2. the Chinese medicine of treatment Research of Senile Dementia Treated according to claim 1 and cerebral infarction, it is characterized in that, by said Radix Rehmanniae Preparata 70g, Fructus Corni 70g, Herba Cistanches 90g, Radix Morindae Officinalis 90g, Cortex Cinnamomi 20g, Radix Ophiopogonis 50g, Herba Dendrobii 70g, Fructus Schisandrae Chinensis 40g, Rhizoma Acori Graminei 40g, Radix Polygalae 40g, Poria 50g, Rhizoma Chuanxiong 50g, Radix Achyranthis Bidentatae 70g, Radix Puerariae 60g makes material medicine and starch, dextrin, magnesium stearate is made as adjuvant, wherein, in the preparation, earlier with Fructus Corni, Radix Puerariae is cleaned oven dry, Cortex Cinnamomi is cleaned cold drying, three flavor medicine mix homogeneously then, pulverized sieve No. 5, get medicated powder, standby, again with Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae ten medicine simply decocts with water twice, add for the first time above-mentioned Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water 6600ml of 10 times of amounts, extracted 2 hours, filter, get filtrate, in medicinal residues, add for the second time Radix Rehmanniae Preparata, Herba Cistanches, Radix Morindae Officinalis, Radix Ophiopogonis, Herba Dendrobii, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Radix Polygalae, Poria, Rhizoma Chuanxiong and Radix Achyranthis Bidentatae ten simply the medicine bulking value and the water 3960ml of 6 times of amounts, extracted 1 hour, filter, merge filtrate twice, be evaporated under 85 ℃, relative density is 1.40 thick paste, will be by Fructus Corni, Radix Puerariae, standby medicated powder that Cortex Cinnamomi is made and thick paste mix homogeneously, 75 ℃ of oven dry down, be ground into fine powder, adding the starch of this fine powder gross weight 5% and 5% dextrin again mixes, spray mass concentration while stirring and be 75% ethanol, granulate in the even back of spray, 80 ℃ of oven dry, get base material, add the starch of this base material weight 5% and 0.5% magnesium stearate again, behind the mixing, with the pelleter compacting in flakes, sugar coating, that is every heavy 0.5g.
CN200910064100XA 2009-01-19 2009-01-19 Chinese medicine for treating cerebropathy Active CN101474361B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN200910064100XA CN101474361B (en) 2009-01-19 2009-01-19 Chinese medicine for treating cerebropathy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200910064100XA CN101474361B (en) 2009-01-19 2009-01-19 Chinese medicine for treating cerebropathy

Publications (2)

Publication Number Publication Date
CN101474361A CN101474361A (en) 2009-07-08
CN101474361B true CN101474361B (en) 2011-03-16

Family

ID=40835189

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200910064100XA Active CN101474361B (en) 2009-01-19 2009-01-19 Chinese medicine for treating cerebropathy

Country Status (1)

Country Link
CN (1) CN101474361B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810814B (en) * 2010-04-28 2011-08-10 史建钢 Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof
CN106692453B (en) * 2017-02-17 2020-02-18 复旦大学附属中山医院 Chinese herbal medicine composition for treating Parkinson's disease and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352817A (en) * 2014-11-21 2015-02-18 郝建国 Traditional Chinese medicine preparation for treating cerebral agenesis and preparation method thereof
CN104524503A (en) * 2014-12-20 2015-04-22 丁立 Traditional Chinese medicine for treatment of stroke
CN104800606A (en) * 2015-04-29 2015-07-29 赵汝君 Traditional Chinese medicine composition for treating Parkinson's syndrome
CN106139025A (en) * 2016-08-11 2016-11-23 河南中医学院 A kind of Chinese medicine treating Cerebral Palsy in Children companion's mental retardation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279943C (en) * 2004-12-16 2006-10-18 贺国政 Chinese medicine for treating brain disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279943C (en) * 2004-12-16 2006-10-18 贺国政 Chinese medicine for treating brain disease

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810814B (en) * 2010-04-28 2011-08-10 史建钢 Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof
CN106692453B (en) * 2017-02-17 2020-02-18 复旦大学附属中山医院 Chinese herbal medicine composition for treating Parkinson's disease and preparation method thereof

Also Published As

Publication number Publication date
CN101474361A (en) 2009-07-08

Similar Documents

Publication Publication Date Title
CN102078520B (en) Chinese medicinal preparation for treating nervous headache and preparation method thereof
CN102078482B (en) Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of the same
CN101810685B (en) Chinese medicinal composition for treating gonitis and preparation method thereof
CN101474361B (en) Chinese medicine for treating cerebropathy
CN101444611A (en) Traditional Chinese medicine composition for treating lumbocrural pain and lumbar intervertebral disc protrusion and preparation method thereof
CN102342992A (en) Chinese medicinal composition for treating insomnia and preparation method of preparation thereof
CN102526474A (en) Chinese medicine composition for treating neurasthenia
CN102058715B (en) Chinese medicine preparation for treating chronic prostatitis and preparation method thereof
CN104922543A (en) Medicine composite for treating amenorrhea and preparation method thereof
CN101698020B (en) Traditional Chinese medicine preparation for treating femoral head necrosis and preparation method thereof
CN105663607A (en) Traditional Chinese medicine composition as well as preparation method and application thereof
CN104958607A (en) Traditional Chinese medicine composition for treating burning mouth syndromes of climacteric women and preparation method thereof
CN102166278A (en) Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
CN101507776B (en) Traditional Chinese medicine preparation for treating kidney deficiency, waist and knees soreness and preparation method thereof
CN101700336B (en) Chinese herba preparation for curing craniocerebra trauma residual headache and preparation method
CN103463354B (en) Traditional Chinese medicine composition for treating insomnia
CN102048913B (en) Traditional Chinese medicine preparation for treating climacteric syndrome and preparation method thereof
CN104474461A (en) Traditional Chinese medicine preparation for treatment of idiopathic trigeminal neuralgia and preparation method thereof
CN101195003B (en) Proprietary Chinese medicine for treating apoplexy and sequela
CN102885953A (en) Traditional Chinese medicine preparation for tonifying kidney and spleen and preparation process thereof
CN105343675A (en) Traditional Chinese medicine preparation for treating adiposis and preparation method thereof
CN100509019C (en) Application of Baji capsule in preparing immune enhancement medicament
CN1075727C (en) Shentong capsule and preparing method thereof
CN102697955A (en) Medicine for treating gynecological diseases
CN106491990B (en) A kind of Chinese medicine composition for treating diabetes B

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant