CN1931300A - Externally applied medicine for treating women's dysmenorrhea - Google Patents
Externally applied medicine for treating women's dysmenorrhea Download PDFInfo
- Publication number
- CN1931300A CN1931300A CNA2006100690110A CN200610069011A CN1931300A CN 1931300 A CN1931300 A CN 1931300A CN A2006100690110 A CNA2006100690110 A CN A2006100690110A CN 200610069011 A CN200610069011 A CN 200610069011A CN 1931300 A CN1931300 A CN 1931300A
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- CN
- China
- Prior art keywords
- externally applied
- applied medicine
- chinese
- medicinal raw
- trumpet creeper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 21
- 206010013935 Dysmenorrhoea Diseases 0.000 title description 8
- 208000005171 Dysmenorrhea Diseases 0.000 title description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 240000007594 Oryza sativa Species 0.000 claims abstract description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 4
- 235000009566 rice Nutrition 0.000 claims abstract description 4
- 235000021419 vinegar Nutrition 0.000 claims abstract description 4
- 239000000052 vinegar Substances 0.000 claims abstract description 4
- 239000003860 topical agent Substances 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 8
- 241001649190 Campsis Species 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 6
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 claims description 3
- 241000218176 Corydalis Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 235000011837 pasties Nutrition 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 239000002689 soil Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 12
- 241001546929 Campsis grandiflora Species 0.000 abstract 4
- 241000402754 Erythranthe moschata Species 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000002791 soaking Methods 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000007605 air drying Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000009552 doppler ultrasonography Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000002266 menstruation inducing agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention is one kind of externally applied medicine administrated via umbilical part to treating women's dysmenorrheal. The externally applied medicine is prepared with 15 kinds of Chinese medicinal materials, including musk, Chinese trumpet creeper, cassia, asarum herb, dahurian angelica root, etc in certain weight proportion. The preparation process includes stoving the Chinese medicinal materials except musk and Chinese trumpet creeper, soaking in alcohol for one week and concentrating the soaked liquid; soaking Chinese trumpet creeper in rice vinegar for 24 hr, air drying and crushing; and mixing musk, the Chinese trumpet creeper powder and the soaked liquid. The externally applied medicine has fast absorption, small dosage, high treating effect and no toxic side effect.
Description
(1) technical field under
The present invention relates to a kind of medicine for the treatment of dysmenorrhes, particularly a kind of topical agent by umbilical region administration, treatment dysmenorrhes.
(2) background technology
Dysmenorrhea is one of commonly encountered diseases of puzzlement adolescence, women's work and study, is having a strong impact on the quality of life of young and middle-aged women.At present commercially available treatment emmenagogue is many based on oral, and its Chinese medicine and western medicine side effect is many; There are deficiencies such as taking dose is big, mouthfeel is poor, administration number of times is many in Chinese medicine decoction and Chinese patent medicine.
(3) summary of the invention
The present invention is in order to overcome the deficiency of above technology, provides that a kind of therapeutic effect is good, easy to use, the topical agent of the treatment dysmenorrhes that has no side effect.
The topical agent of treatment dysmenorrhes of the present invention is characterized in that the topical agent made by the medicinal raw material and the preparation method of following weight portion,
Medicinal raw material: Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g;
Preparation method: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt 50-70% edible ethanol one week of infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;
Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;
Moschus sneak into above-mentioned 14 the flavor medicines in, behind the mix homogeneously promptly.
The effect of liniment of the present invention: promoting QI circulation for relieving depression, regulating menstruation and activating blood, the detumescence of relieving oedema or abdominal distension through diuresis or purgation, understand things pain-stopping.
Cure mainly: primary dysmenorrhea, menoxenia etc.
Medicament of the present invention promotes whole body and local blood circulation by through umbilical region administration, and the menstrual molimen emotion of releiving absorbs soon, and using dosage is little, and number of times is few, the safe ready health.Clinical experiment shows that curative effect of medicine of the present invention is fast, and is effective, has no side effect.
(4) specific embodiment
The present embodiment medicine is a kind of topical agent for the treatment of dysmenorrhes, and its medicinal raw material is:
Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g.
Preparation method is: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt one week of 60% edible ethanol infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;
Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;
Moschus sneak into above-mentioned 14 the flavor medicines in, be mixed into paste after, topical agent of the present invention.
Usage: get this product 2g and be applied on the adhesive plaster, be affixed on umbilical part, changed once in 48 hours, pass through sticked in preceding 3 days, and manifold card applies 3 and passes through the cycle.
Carry out following clinical trial:
According to the dysmenorrhea criterion of therapeutical effect that Ministry of Public Health bureau of drug administration formulates, choose light, in, severe pain is through person's (dysmenorrhea group) 100 examples, age 15-30 year, course of disease 2-10, selecting 30 dysmenorrhea persons else is matched group, age 15-30 year.Fill in questionnaire by the special messenger, detailed medical history-taking, organ diseases such as the comprehensive health check-up of warp all is not in the mood for, brain, kidney, and through abdominal part color doppler ultrasonography instrument detection uterus and the whole no abnormal findings of adnexa.
Therapeutic Method:
1 treatment group: the unguentum 2g that gets this foregoing description is applied on the adhesive plaster, is affixed on umbilical part, changes once in 48 hours, and pass through sticked in preceding 3 days, and manifold card applies 3 and passes through the cycle.
2 matched groups: oral somedon, 1 slice/time, 1-2 time/day, took medicine through preceding 3 days, serve on 5 days, serveing on 3 menstrual cycle is a course of treatment.
Efficacy result
Criterion of therapeutical effect: press the curative effect determinate standard that Ministry of Public Health bureau of drug administration formulates
Recent clinical cure: pain and other transference cure after the drug withdrawal, 3 cycles of drug withdrawal do not recur, and pain degree reverts to " 0 " degree.
Produce effects: reduce to below 1/2 of original branch
Effectively: reduce to below 1/3 of original branch
Invalid: as not have change.
After all case observation is finished three menstrual cycle,, the results are shown in Table 1 according to above standard determination curative effect.
Table 1: two groups of patients clinical curative effects of medicament of the present invention and somedon relatively
| Group | Example number (example) | Cure (example) | Produce effects (example) | Effectively (example) | Invalid (example) | Total effective rate |
| Medicament of the present invention | 100 | 40 | 35 | 20 | 5 | 95％ |
| Somedon | 30 | 1 | 12 | 13 | 4 | 86.7％ |
Respectively the patient's (40 example) before and after the treatment is measured with healthy people's (20 example) hemorheology index, the results are shown in Table 2.In the table 2, one group is the hemorheology index before the dysmenorrhoea disease human therapy, and two groups is one group of hemorheology index behind the dysmenorrhoea disease human therapy, and three groups is healthy people's hemorheology index.
Table 2: two groups of hemorheology indexs of medicament of the present invention and somedon relatively
| Group | The example number | Whole blood viscosity | Plasma viscosity (mps) | The whole blood reduced viscosity | Erythrocyte sedimentation rate | Packed cell volume (%) | |
| Height is cut | Low cutting | ||||||
| One group | 40 | 5.62±0.57 △ | 17.51±1.27 △ | 2.56±0.47 △ | 10.63±1.19 △ | 6.89±4.97 △△ | 42.69±2.80 △△ |
| Two groups | 40 | 5.18±0.08 # | 15.78±0.09 ## | 1.94±0.02 # | 9.75±0.23 # | 9.64±0.49 # | 36.55±1.05 # |
| Three groups | 20 | 4.99±0.47 | 15.64±0.75 | 1.79±0.24 | 9.56±1.26 | 10.19±2.65 | 37.09±4.24 |
Annotate: control preceding comparison with this group,
#P＜0.05,
##P＜0.01;
Organize comparison with healthy people,
△P＜0.05,
△ △P＜0.01
Conclusion:
Experiment shows that significant difference is arranged between two groups, illustrates that medicament of the present invention is greatly improved on curative effect, has better therapeutic effect clinically.
Use the patient of medicament of the present invention, do not have any untoward reaction, illustrate without any side effects.
Claims (1)
1. topical agent for the treatment of dysmenorrhes is characterized in that the topical agent made by the medicinal raw material and the preparation method of following weight portion,
Medicinal raw material: Cortex Cinnamomi 6g, Herba Asari 6g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 6g, Rhizoma Atractylodis 6g, Fructus Sinopodophylli 5g, Semen Sinapis 6g, Rhizoma Cyperi 6g, Caulis Spatholobi 9g, Semen Euphorbiae 12g, Herba Centellae 7g, Rhizoma Corydalis 9g, Herba Lycopi 6g, Flos Campsis 9g, Moschus 0.25g;
Preparation method: claim above-mentioned preceding 13 flavor medicinal raw materials to golden yellow, after the cooling, are put into wt 50-70% edible ethanol one week of infusion with the Yellow River sandy soil heating, drying, filter, the filtrate vacuum concentration becomes pasty state;
Flos Campsis is taken out after 24 hours with the rice vinegar infusion, and airing is crushed to the 120-150 order;
Moschus sneak into above-mentioned 14 the flavor medicines in, behind the mix homogeneously promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100690110A CN100540030C (en) | 2006-09-20 | 2006-09-20 | A kind of topical agent for the treatment of dysmenorrhes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100690110A CN100540030C (en) | 2006-09-20 | 2006-09-20 | A kind of topical agent for the treatment of dysmenorrhes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931300A true CN1931300A (en) | 2007-03-21 |
| CN100540030C CN100540030C (en) | 2009-09-16 |
Family
ID=37877425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100690110A Expired - Fee Related CN100540030C (en) | 2006-09-20 | 2006-09-20 | A kind of topical agent for the treatment of dysmenorrhes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100540030C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250617A (en) * | 2015-11-28 | 2016-01-20 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating congealing cold blood stasis type primary dysmenorrhea |
| CN106266409A (en) * | 2016-11-10 | 2017-01-04 | 钟新菊 | A kind of promoting the flow of QI in the collateral by warming the meridian Chinese medicine external patch and preparation method thereof |
| CN113440500A (en) * | 2021-08-19 | 2021-09-28 | 广州市一善堂医疗保健顾问有限公司 | Plaster for treating dysmenorrhea and preparation method thereof |
-
2006
- 2006-09-20 CN CNB2006100690110A patent/CN100540030C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250617A (en) * | 2015-11-28 | 2016-01-20 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating congealing cold blood stasis type primary dysmenorrhea |
| CN106266409A (en) * | 2016-11-10 | 2017-01-04 | 钟新菊 | A kind of promoting the flow of QI in the collateral by warming the meridian Chinese medicine external patch and preparation method thereof |
| CN113440500A (en) * | 2021-08-19 | 2021-09-28 | 广州市一善堂医疗保健顾问有限公司 | Plaster for treating dysmenorrhea and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100540030C (en) | 2009-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: LI YUNXIANG; APPLICANT Free format text: FORMER OWNER: FENG DEYI Effective date: 20071214 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20071214 Address after: Postal code of Zoucheng people's Hospital, Jining City, Shandong Province, China: 273500 Applicant after: Li Yun Xiang Co-applicant after: He Jinghua Co-applicant after: He Shumin Co-applicant after: Li Xiangxia Address before: Postcode 4, No. ten, Lixia District, Ji'nan City, Shandong Province, China: 250014 Applicant before: Feng Deyi |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090916 Termination date: 20100920 |