CN113440500A - Plaster for treating dysmenorrhea and preparation method thereof - Google Patents
Plaster for treating dysmenorrhea and preparation method thereof Download PDFInfo
- Publication number
- CN113440500A CN113440500A CN202110955440.2A CN202110955440A CN113440500A CN 113440500 A CN113440500 A CN 113440500A CN 202110955440 A CN202110955440 A CN 202110955440A CN 113440500 A CN113440500 A CN 113440500A
- Authority
- CN
- China
- Prior art keywords
- parts
- plaster
- dysmenorrhea
- rhizoma
- treating dysmenorrhea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of medicines, and particularly relates to a plaster for treating dysmenorrhea and a preparation method thereof. The plaster for treating dysmenorrhea is prepared from the following raw materials in parts by weight: 25-30 parts of turmeric, 25-30 parts of piper longum, 25-30 parts of rhizoma corydalis, 15-20 parts of clove, 25-30 parts of angelica, 10-15 parts of cinnamon, 15-20 parts of asarum, 10-20 parts of frankincense, 10-20 parts of myrrh, 15-20 parts of rhizoma cyperi, 15-20 parts of fructus evodiae and 10-15 parts of dried ginger. The raw material medicaments of the invention have the synergistic enhancement effect, can have good effect of treating dysmenorrhea, and the form of the plaster is more easily accepted by patients.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a plaster for treating dysmenorrhea and a preparation method thereof.
Background
The dysmenorrhea is primary dysmenorrhea and secondary dysmenorrhea in modern medicine. Primary dysmenorrhea refers to dysmenorrhea caused by uterine hypercontractility/vasospasm due to increased content of prostaglandin in endometrium, resulting in uterine ischemia and anoxia. The secondary dysmenorrhea is usually endometriosis, and ectopic focus is affected by periodic ovarian hormone to cause hyperplasia, hemorrhage and pain. The pathogenesis of dysmenorrhea considered in traditional Chinese medicine is as follows: the excess syndrome is the pain caused by the obstruction of uterus by blood stasis due to sudden changes of constitutions such as damp-heat, qi stagnation and blood stasis, cold accumulation in uterus, etc. Deficiency syndrome is the pain caused by malnutrition of uterus due to deficiency of spleen and stomach, deficiency of qi and blood, and deficiency of kidney qi.
With the change of social development and life style and working habits of people, the health of vast women is seriously influenced by popularization of air conditioners, use of refrigerators, diversified frozen beverages, overnight living habits and the like. Clinical data show that the onset population of dysmenorrhea is rapidly increased every year, and dysmenorrhea is frequent in age from the former adolescence but is common in women from the adolescence to the middle-aged.
At present, various treatments are available for dysmenorrhea, the common treatment mode of western medicine is mainly pain-relieving medicines, and some physical treatments, such as hot compress and hot water bag, hot pad, moxibustion, foot bath, etc., are available. Most of them are the treatment of symptoms and root causes, and there is also some side effect. Based on the above, the medicine which has definite curative effect, treats both principal and secondary aspects of diseases, has few side effects and is suitable for long-term recuperation is urgently needed. Therefore, Chinese patent CN103736030A discloses a Chinese herbal compound preparation for treating dysmenorrhea and a preparation method and application thereof, wherein the Chinese herbal compound preparation is prepared from the following raw material medicines in parts by weight: 1-15 parts of safflower, 1-15 parts of frankincense, 1-15 parts of myrrh, 1-15 parts of rhizoma wenyujin concisum, 1-15 parts of cassia twig, 1-15 parts of dalbergia wood, 1-9 parts of dragon's blood, 1-15 parts of radix linderae, 1-18 parts of rhizoma corydalis, 1-9 parts of folium artemisiae argyi, 1-9 parts of asarum and 0.5-9 parts of borneol. Although it can treat dysmenorrhea, dysmenorrhea is classified into primary dysmenorrhea and secondary dysmenorrhea, and primary dysmenorrhea is related to local lesions of reproductive organs and endocrine, nervous and mental factors, and is mainly caused by uterine contractility enhancement, uterine blood flow reduction, pituitary hormone influence and neurotransmitter action. To solve the fundamental problem, continuous exploration is needed.
Disclosure of Invention
The invention aims to provide a plaster for treating dysmenorrhea and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a plaster for treating dysmenorrhea is prepared from the following raw materials in parts by weight: 25-30 parts of turmeric, 25-30 parts of piper longum, 25-30 parts of rhizoma corydalis, 15-20 parts of clove, 25-30 parts of angelica, 10-15 parts of cinnamon, 15-20 parts of asarum, 10-20 parts of frankincense, 10-20 parts of myrrh, 15-20 parts of rhizoma cyperi, 15-20 parts of fructus evodiae and 10-15 parts of dried ginger.
Preferably, the feed additive is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longum, 30 parts of rhizoma corydalis, 18 parts of clove, 30 parts of angelica, 12 parts of cinnamon, 18 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 18 parts of rhizoma cyperi, 18 parts of fructus evodiae and 15 parts of dried ginger.
The invention also aims to provide a preparation method of the plaster for treating dysmenorrhea, which comprises the following steps:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 meshes and 200 meshes, and mixing well to obtain a mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit to prepare a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on a medicinal plaster of sterilized cotton.
Preferably, the weight ratio of the high-degree white spirit to the raw materials is 4-7: 1.
the raw materials used in the invention have the following effects:
turmeric: nature and taste: pungent, bitter and warm in flavor enter liver and spleen meridians. Comprising: promoting blood circulation, removing blood stasis, dredging channels, relieving pain, warming and dredging channels, activating qi-flowing, and warming middle-jiao.
After drawing: nature and taste: pungent and hot. It enters stomach, spleen and large intestine meridians. Comprising: warming middle energizer to dispel cold, descending qi to alleviate pain.
Rhizoma corydalis: nature and taste: pungent and bitter. It enters heart, spleen, liver and kidney meridians. Comprising: promoting blood circulation, activating qi-flowing, relieving pain, and inducing diuresis.
Clove: nature and taste: pungent and warm. It enters spleen, stomach, lung and kidney meridians. Comprising: has effects in warming middle energizer, lowering adverse flow of qi, invigorating kidney, supporting yang, promoting circulation of qi, and relieving pain.
Chinese angelica: nature and taste: sweet, pungent and bitter. It enters liver and spleen meridians. Comprising: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestines and relaxing bowels.
Cinnamon: nature and taste: pungent and sweet with big heat. It enters kidney, spleen, heart and liver meridians. Comprising: nourishing fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, and dredging channels and collaterals.
Asarum: nature and taste: pungent and warm with slight toxicity. It enters heart, kidney and lung meridians. Comprising: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, warming lung, and eliminating fluid retention.
Frankincense: nature and taste: pungent, bitter and warm. It enters heart, liver and spleen meridians. Comprising: promoting blood circulation, relieving pain, dredging channels, eliminating swelling, and promoting granulation.
Myrrh: nature and taste: pungent, bitter and mild. It enters heart, liver and spleen meridians. Comprising: dissipating blood stasis, relieving pain, promoting the subsidence of swelling, promoting granulation, regulating qi, and promoting blood circulation.
Rhizoma cyperi: nature and taste: pungent, slightly bitter and mild. It enters liver, spleen and triple energizer meridians. Comprising: soothing liver, regulating menstruation, relieving pain, regulating qi and regulating middle warmer.
Evodia fruit: nature and taste: pungent, bitter, warm and toxic. It enters liver and stomach meridians. Comprising: dispelling cold, resolving stagnation, relieving psychroalgia of heart and abdomen, tonifying yang, and relieving diarrhea.
Dried ginger: nature and taste: pungent and warm. It enters spleen, stomach, kidney, heart and lung meridians. Comprising: warming middle energizer to dispel cold, warming lung to resolve retained fluid, restoring yang and dredging collaterals.
Compared with the prior art, the invention has the following beneficial effects:
(1) the plaster can be directly applied to the lower abdomen and important acupuncture points, various raw medicines play a role in synergistic enhancement, follow the structures of monarch, minister, assistant and guide of the traditional Chinese medicine formula, can exert the drug effect to the maximum extent, and has the effects of warming middle-jiao to dispel cold, promoting blood circulation to remove blood stasis, regulating vital energy to relieve pain, and removing old and promoting tissue regeneration, thereby achieving the purpose of treating dysmenorrhea.
(2) The invention adopts a plaster form, avoids oral administration, is convenient for patients to receive, and avoids treatment delay caused by fear of taking medicine.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
Example 1A plaster for treating dysmenorrhea
The feed is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longum, 30 parts of rhizoma corydalis, 18 parts of clove, 30 parts of angelica, 12 parts of cinnamon, 18 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 18 parts of rhizoma cyperi, 18 parts of fructus evodiae and 15 parts of dried ginger.
The preparation method of the plaster for treating dysmenorrhea comprises the following steps:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 mesh, and mixing to obtain mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit for 3 months to obtain a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on the medicinal plaster of the sterilized cotton to obtain the medicinal liquor bag.
Example 2A plaster for treating dysmenorrhea
The feed is prepared from the following raw materials in parts by weight: 25 parts of turmeric, 25 parts of piper longum, 25 parts of rhizoma corydalis, 15 parts of clove, 25 parts of angelica, 10 parts of cinnamon, 15 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 15 parts of rhizoma cyperi, 15 parts of fructus evodiae and 10 parts of dried ginger.
The preparation method of the plaster for treating dysmenorrhea comprises the following steps:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 mesh, and mixing to obtain mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit for 3 months to obtain a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on the medicinal plaster of the sterilized cotton to obtain the medicinal liquor bag.
Example 3A plaster for treating dysmenorrhea
The feed is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longifolia, 30 parts of rhizoma corydalis, 20 parts of clove, 30 parts of angelica, 15 parts of cinnamon, 20 parts of asarum, 20 parts of frankincense, 20 parts of myrrh, 20 parts of rhizoma cyperi, 20 parts of fructus evodiae and 15 parts of dried ginger.
The preparation method of the plaster for treating dysmenorrhea comprises the following steps:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 1000 mesh, and mixing to obtain mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit for 3 months to obtain a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on the medicinal plaster of the sterilized cotton to obtain the medicinal liquor bag.
Comparative example 1 plaster for treating dysmenorrhea
The feed is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longum, 30 parts of rhizoma corydalis, 18 parts of clove, 30 parts of angelica, 12 parts of cinnamon, 18 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 18 parts of fructus evodiae and 15 parts of dried ginger.
The preparation method of the plaster for treating dysmenorrhea comprises the following steps:
s1), weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 mesh, and mixing to obtain mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit for 3 months to obtain a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on the medicinal plaster of the sterilized cotton to obtain the medicinal liquor bag.
Comparative example 2 plaster for treating dysmenorrhea
The feed is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longifolia, 30 parts of rhizoma corydalis, 30 parts of angelica, 12 parts of cinnamon, 18 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 18 parts of rhizoma cyperi, 18 parts of fructus evodiae and 15 parts of dried ginger.
The preparation method of the plaster for treating dysmenorrhea comprises the following steps:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 mesh, and mixing to obtain mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit for 3 months to obtain a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on the medicinal plaster of the sterilized cotton to obtain the medicinal liquor bag.
Experiment I, animal drug effect experiment
1.1 Experimental procedures
Healthy non-pregnant female SD rats with a weight of 250 + -20 g were randomly divided into 4 groups of 5 animals, namely, a control group and an administration group (experimental group, comparative example 1 group and comparative example 2 group). Each group was fed diethylstilbestrol at a concentration of 0.5mg/ml per day for 2 days. During the experiment, the rat is sacrificed by cervical dislocation, one side uterus is taken rapidly and connective tissues and fat on the wall of the uterus are peeled off, the two ends of the uterus are tied by medical real silk braided wires, wherein, one end of the rope is tied to the tail end of the uterine horn side, and the length is about 2 +/-0.1 cm. The cervical end was fixed to a bath containing a constant temperature Locke's solution saturated with air, the ovarian end was connected to a sensor, and the specimen was preloaded with 2 g. The bath temperature was maintained at 37.5. + -. 0.5 ℃. And starting a physiological signal acquisition system, and balancing for 30 min. Then adding the administration group into the bath lotion, controlling the bath lotion concentration to be 0.09g/L, and adding distilled water to the control group. After spontaneous contraction of the uterine smooth muscle is stable and spontaneous rhythm is recovered, oxytocin (final concentration of 5U/L) is added for observation and recording for 9min, and each group is observed and recorded for 9min after administration.
1.2 results of the experiment
TABLE 1 Effect of different medicinal liquids on the contractile tension of isolated uterine smooth muscle of rat
As can be seen from Table 1, compared with the model group, the comparative example 1 group and the comparative example 2 group, the average inhibition rate of the experimental group is high, and the contraction tension of the isolated uterine smooth muscle of the rat can be remarkably reduced.
Experiment two, clinical experiment
2.1 clinical data
150 dysmenorrhea patients are selected from 1 month to 2021 month to 7 months in 2019, women are aged from 13 to 42 years, and the disease period is 1 to 35 years. The cases were randomized into 2 groups, 75 in the treatment group and 75 in the control group. The sex composition, age and course of disease of the two groups of patients are approximately similar and have no significant difference.
2.2 methods of treatment
The medicinal plaster of the invention is applied to the specified position according to the requirements. The plaster is applied once a day for 4-6 hours each time for 1-5 treatment courses. Control group: taking analgesic, once daily ibuprofen, one granule each time, and adding warm baby product for external application, and treating the serious disease according to the medical advice.
2.3 diagnostic criteria for therapeutic efficacy
And (3) curing: the original symptoms and physical signs disappear, the physiological period is continuously monitored for half a year without painful menstruation, and the menstruation is smooth.
The method has the following advantages: the original symptoms are reduced, the physiological symptoms are obviously improved after half-year monitoring, and the menstruation is smoother than before.
And (4) invalidation: symptoms before and after treatment, no improvement or aggravation of body weight.
2.4 therapeutic results
TABLE 2 comparison of results after treatment
| Group of | Number of examples | Recovery method | Show effect | Is effective | Invalidation | Total effective rate |
| Treatment group | 75 | 59 | 7 | 6 | 3 | 96％ |
| Control group | 75 | 24 | 18 | 25 | 8 | 89.3％ |
The two groups of curative effects have significant difference (p is less than 0.001)
2.5 side effects and contraindications
No toxic or side effect is found through clinical application of 75 patients. It is forbidden for pregnant women and people with menorrhagia.
2.6 detailed cases
Zhou Zhi, female, age 29, white collar, with dysmenorrhea for 8 years, lower abdominal pain before each menstruation, accompanied by tenesmus and tenesmus of the waist, weakness of the lower limbs, and dark and bloody menses. The plaster prepared by the invention has the advantages that the symptoms are obviously improved after 1 course of treatment, and the symptoms are all cured after 3 courses of continuous use. No relapse is found in the follow-up one year.
Zhangqi, female, 14 years old, students, in adolescence, first menstruation, stabbing pain in lower abdomen, inability to lie flat, scanty menstruation volume, cold hands and feet. When the plaster prepared by the invention is used for 1 time, the pain is immediately and obviously relieved, and the patient can lie on the bed. After the plaster prepared by the invention is used for 3 courses of treatment, the symptoms are all cured, and no recurrence is seen after one year and a half of follow-up visit.
Liu Yi, female, age 26, teacher with dysmenorrhea for 7 years, beginning discomfort three days before each menstruation, lower abdomen distention, chest and costalgia, dark and gloomy color of menstruation, blood clots, and small amount. The symptoms are basically cured after 2 courses of treatment of the plaster prepared by the invention. The patients are followed up for half a year without relapse.
Linger certain, female, age 35, housewife, suffering from dysmenorrhea for 19 years, premenstrual lower abdominal pain, anorexia, nausea, vomiting, chills in the loins and knees, scanty menstruation and blood clots. After 1 treatment course, the pain of the plaster prepared by the invention disappears, the waist and the knees are relieved from cold, and blood clots occasionally occur. After the patient insists on three courses of treatment, the symptoms are cured. After half a year of follow-up, no recurrence is observed.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (5)
1. The plaster for treating dysmenorrhea is characterized by being prepared from the following raw materials in parts by weight: 25-30 parts of turmeric, 25-30 parts of piper longum, 25-30 parts of rhizoma corydalis, 15-20 parts of clove, 25-30 parts of angelica, 10-15 parts of cinnamon, 15-20 parts of asarum, 10-20 parts of frankincense, 10-20 parts of myrrh, 15-20 parts of rhizoma cyperi, 15-20 parts of fructus evodiae and 10-15 parts of dried ginger.
2. The plaster for treating dysmenorrhea according to claim 1, which is prepared from the following raw materials in parts by weight: 30 parts of turmeric, 30 parts of piper longum, 30 parts of rhizoma corydalis, 18 parts of clove, 30 parts of angelica, 12 parts of cinnamon, 18 parts of asarum, 10 parts of frankincense, 10 parts of myrrh, 18 parts of rhizoma cyperi, 18 parts of fructus evodiae and 15 parts of dried ginger.
3. The method for preparing the plaster for treating dysmenorrhea according to claim 1 or 2, comprising the steps of:
s1) weighing Curcuma rhizome, fructus Piperis Longi, rhizoma corydalis, flos Caryophylli, radix Angelicae sinensis, cortex Cinnamomi, herba asari, Olibanum, Myrrha, rhizoma Cyperi, fructus evodiae and Zingiberis rhizoma respectively, pulverizing to 100 meshes and 200 meshes, and mixing well to obtain a mixture;
s2) wrapping the mixture obtained in the step S1 with sterilized cotton to obtain a plaster;
s3) soaking the plaster obtained in the step S2 in high-alcohol-content white spirit to prepare a medicinal liquor bag, and uniformly pouring the medicinal liquor bag on a medicinal plaster of sterilized cotton.
4. The preparation method of the plaster for treating dysmenorrhea according to claim 3, wherein the weight ratio of the high-alcohol-content white spirit to the raw materials is 4-7: 1.
5. use of a patch according to any one of claims 1-2 or a patch prepared by a process according to any one of claims 3-4 for the manufacture of a medicament for the treatment of dysmenorrhea.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114984164A (en) * | 2022-06-08 | 2022-09-02 | 台州市第二人民医院 | Plaster for treating pelvic pain and dysmenorrhea |
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| CN102178922A (en) * | 2011-05-04 | 2011-09-14 | 张爱霞 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
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2021
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| CN1686296A (en) * | 2005-03-30 | 2005-10-26 | 何周荣 | Medicinal composition for treating soreness, its preparation method and application |
| CN1931300A (en) * | 2006-09-20 | 2007-03-21 | 冯德义 | Externally applied medicine for treating women's dysmenorrhea |
| CN101342355A (en) * | 2008-08-21 | 2009-01-14 | 李翠静 | Compound evodia rutaecarpa mixed medicament for treating dysmenorrhea |
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| CN114984164A (en) * | 2022-06-08 | 2022-09-02 | 台州市第二人民医院 | Plaster for treating pelvic pain and dysmenorrhea |
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Application publication date: 20210928 |