CN108815488A - Treat compound essential oil preparation of dysmenorrhea and preparation method thereof and application method - Google Patents
Treat compound essential oil preparation of dysmenorrhea and preparation method thereof and application method Download PDFInfo
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Abstract
The present invention provides a kind of compound essential oil preparation for treating dysmenorrhea and preparation method thereof and application methods, are related to essential oil formulation technical field, and the essential oil composition preparation includes following component according to the mass fraction：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil, 0.25-0.8 parts of P-Cymene, 0.4-1 parts of Lavender, 0.2-0.5 parts of Geranium Essential, 0.2-0.5 parts and ginger essential oil 0.1-0.4 parts of Basil Essential, it alleviates and takes anodyne treatment dysmenorrhea for a long time, though symptom can be alleviated, but it cannot eradicate, and the technical issues of side reaction can be generated, essential oil composition provided by the invention not only has very strong fat-soluble and penetrating power, and there is pungent perfume (or spice) to walk to alter, fragrant qi-regulating and promoting blood circulation and stopping pain effect, it is significant to relieve pain regulating menoxenia, external medication can also be passed through simultaneously, it is simple and efficient.
Description
Technical field
The present invention relates to essential oil formulation technical fields, more particularly, to a kind of compound essential oil preparation for treating dysmenorrhea and its system
Preparation Method and application method.
Background technique
Dysmenorrhea refers to pass through front and back or painful menstrual periods, is in hypogastralgia, falling inflation, the soreness of waist, and other symptoms include having a headache, being weary
Power, dizziness, nausea etc., pelvic cavity, genital tract are without organic disease.Dysmenorrhea is that women is common, high morbidity, mostly occurs in puberty
Women shows that China dysmenorrhea women accounts for 33.19%, and wherein dysmenorrhea accounts for 75% according to investigations.
With China's expanding economy, the realistic problems such as women work and life dual-pressure is big easily cause or aggravate pain
Through.Dysmenorrhea is long-term, recurrent exerbation not only brings great body and mind pain to women, often because pain compared with acutely due to influence patient normal
Life and work.
Currently for the treatment of dysmenorrhea, modern medicine is mainly swashed using oral prostaglandin synthase inhibitor, non-steroidal
The analgesic drug products such as plain class drug, spasmolysis and analgesia class drug and calcium and magnesium preparation are treated, though however anodyne can alleviate symptom,
But it cannot eradicate, and the long-term analgesic drug product that relies on can generate the side reactions such as nausea, the reduction of gastrointestinal mucosa ulcer, abdominal pain, granulocyte,
And curative effect cannot be lasting, is not suitable for being used for a long time.
In view of this, the present invention is specifically proposed.
Summary of the invention
One of the objects of the present invention is to provide a kind of compound essential oil preparations for treating dysmenorrhea, are stopped with alleviating long-term use
Pain medicine treatment dysmenorrhea cannot eradicate though can alleviate symptom, and can generate side reaction, be not suitable for the technical issues of being used for a long time.
The compound essential oil preparation for the treatment of dysmenorrhea provided by the invention, including following component according to the mass fraction：Tanquedate
It is 1-3 parts oily, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil, P-Cymene 0.25-
0.8 part, 0.4-1 parts of Lavender, 0.2-0.5 parts of Geranium Essential, 0.2-0.5 parts of Basil Essential and ginger essential oil 0.1-
0.4 part.
Further, the compound essential oil preparation of the treatment dysmenorrhea, including following component according to the mass fraction：Tanquedate
It is 1.5-2.5 parts oily, 0.7-1.2 parts of Rhizoma Chuanxiong essential oil, 0.4-0.6 parts of root bark of tree peony essential oil, 0.25-0.4 parts of rhizoma cyperi essential oil, P-Cymene
0.2-0.7 parts, 0.45-0.8 parts of Lavender, 0.3-0.4 parts of Geranium Essential, 0.3-0.4 parts of Basil Essential and ginger extract
It is 0.2-0.3 parts oily.
Further, the compound essential oil preparation of the treatment dysmenorrhea, including following component according to the mass fraction：Tanquedate
It is 2-2.5 parts oily, 0.7-1 parts of Rhizoma Chuanxiong essential oil, 0.45-0.55 parts of root bark of tree peony essential oil, 0.25-0.35 parts of rhizoma cyperi essential oil, P-Cymene
0.2-0.5 parts, 0.45-0.7 parts of Lavender, 0.3-0.4 parts of Geranium Essential, 0.3-0.4 parts of Basil Essential and ginger extract
It is 0.2-0.3 parts oily.
Further, the compound essential oil preparation of the treatment dysmenorrhea further includes 90-98 parts of base oil according to the mass fraction,
Preferably 91.4-96.7 parts, be still more preferably 92-96 parts；
Preferably, the base oil in Sweet Almond Oil, He Baba oil, grape seed oil or wheat-germ oil at least one
Kind, preferably SIMMONDSIA CHINENSIS SEED OIL.
Further, angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, India
Certain herbaceous plants with big flowers essential oil, Basil Essential and ginger essential oil respectively by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the root bark of tree peony, rhizoma cyperi, folium artemisiae argyi, lavender, fish pelargonium, sweet basil and
It extracts to obtain by steam distillation in ginger.
Further, the compound essential oil preparation of the treatment dysmenorrhea, further includes pharmaceutically acceptable auxiliary material；
Preferably, the auxiliary material includes excipient, binder, filler, lubricant, antioxidant, preservative or thickening
At least one of agent.
Further, the dosage form of the compound essential oil preparation of the treatment dysmenorrhea is external preparation；
Preferably, the dosage form of the preparation is patch, cream, micro emulsion gels, suspension or microcapsule formulations.
The second object of the present invention is to provide the preparation method of the compound essential oil preparation of above-mentioned treatment dysmenorrhea, including as follows
Step：By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, sieve
It strangles essential oil and ginger essential oil and optional base oil is uniformly mixed to get the compound essential oil preparation for the treatment of dysmenorrhea is arrived.
Further, the preparation method of the compound essential oil preparation of the treatment dysmenorrhea, includes the following steps：By tanquedate
Oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, Basil Essential and ginger extract
Oil sequentially adds in base oil, is uniformly mixed, and obtains the compound essential oil preparation for the treatment of dysmenorrhea.
The third object of the present invention is to provide the application method of the compound essential oil preparation of above-mentioned treatment dysmenorrhea, including as follows
Step：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel Yu the lower three cun of underbellies of navel.
The fifth purpose of the invention is to provide the application method of the compound essential oil preparation of above-mentioned treatment dysmenorrhea, including such as
Lower step：In menalgia or 3-7 days before menstrual period, compound essential oil preparation is applied to the pass member of navel and the lower three cun of underbellies of navel
Cave.
Basil Essential and ginger essential oil coordinated not only have very strong fat-soluble and penetrating power, quick by body
It absorbs, and there is pungent perfume (or spice) to walk to alter, fragrant qi-regulating and promoting blood circulation and stopping pain effect, analgesic regulating menoxenia is significant, while can also pass through
External medication, safe and efficient, simple and efficient, patient acceptance is higher, and compliance is stronger.
The preparation method simple process of the compound essential oil preparation for the treatment of dysmenorrhea provided by the invention, easy to operate, Neng Goushi
For industrialized production, production efficiency is improved.
The compound essential oil preparation for the treatment of dysmenorrhea provided by the invention, with the compound essential oil system for the treatment of dysmenorrhea provided by the invention
Agent is effective component, passes through angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, India
Certain herbaceous plants with big flowers essential oil, Basil Essential and ginger essential oil coordinated not only have very strong fat-soluble and penetrating power, are quickly inhaled by body
It receives, and there is pungent perfume (or spice) to walk to alter, fragrant qi-regulating and promoting blood circulation and stopping pain effect, analgesic regulating menoxenia is significant, while can also pass through body
Externally applied drug, simple and efficient, patient acceptance is higher, and compliance is stronger.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of compound essential oil preparations for treating dysmenorrhea, including press matter
Measure the following component of number meter：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil
0.2-0.4 parts, 0.25-0.8 parts of P-Cymene, 0.4-1 parts of Lavender, 0.2-0.5 parts of Geranium Essential, Basil Essential
0.2-0.5 parts and ginger essential oil 0.1-0.4 parts.
In the present invention, the typical but non-limiting mass fraction for example 1 of angelica essential oil, 1.1,1.2,1.3,1.4,
1.5,1.6,1.71.8,1.9,2,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9 or 3 part.
Angelica essential oil replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels are used for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, warp
Close dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia, ulcer sores.
In the present invention, the typical but non-limiting mass fraction for example 0.6 of Rhizoma Chuanxiong essential oil, 0.65,0.7,0.75,
0.8,0.85,0.9,0.95,1,1.05,1.1,1.15,1.2,1.25,1.3,1.35,1.4,1.45 or 1.5 part.
Rhizoma Chuanxiong essential oil blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, amenorrhea and algomenorrhea, abdominal mass abdominal pain, pricking pain in the chest.
In the present invention, the typical but non-limiting mass fraction for example 0.3 of root bark of tree peony essential oil, 0.35,0.38,0.4,
0.42,0.45,0.48,0.5,0.52,0.55,0.58,0.6,0.62,0.65,0.68 or 0.7 part.
Root bark of tree peony essential oil clearing heat and cooling blood, activating microcirculation and removing stasis medicinal.For febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, warp
Close dysmenorrhea, carbuncle sore tumefacting virus, the pain of injury caused by falling and tumbling.
In the present invention, the typical but non-limiting mass fraction for example 0.2 of rhizoma cyperi essential oil, 0.21,0.22,0.23,
0.24、0.25、0.26、0.27、0.28、0.29、0.3、0.31、0.32、0.33、0.34、0.35、0.36、0.37、0.38、
0.39 or 0.4 part.
Rhizoma cyperi essential oil promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian
It is bored, cold hernia stomachache, swollen breasts, irregular menstruation, amenorrhea and algomenorrhea.
In the present invention, the typical but non-limiting mass fraction for example 0.25 of P-Cymene, 0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75 or 0.8 part.
P-Cymene eliminating cold to stop pain, warming channel for arresting bleeding.
In the present invention, the typical but non-limiting mass fraction for example 0.45 of Lavender, 0.48,0.5,
0.52,0.55,0.58,0.6,0.62,0.65,0.68,0.7,0.72,0.75,0.78 or 0.8 part.
Lavender is releived intense strain, the calm mind, calms down pneumostatic, also has spasmolysis to ileum and uterine smooth muscle
Effect.
In the present invention, the typical but non-limiting mass fraction for example 0.2 of Geranium Essential, 0.22,0.25,
0.28,0.3,0.32,0.35,0.38,0.4,0.42,0.45,0.48 or 0.5 part.
Geranium Essential can promote blood circulation, relieve pain, antibacterial, improve premenstrual syndrome, strengthens circulatory function, makes to follow
Ring is more smooth.
In the present invention, the typical but non-limiting mass fraction for example 0.2 of Basil Essential, 0.22,0.25,0.28,
0.3,0.32,0.35,0.38,0.4,0.42,0.45,0.48 or 0.5 part.
Basil Essential is extracted from sweet basil, and analgesia can be relieved pain, and substantially improves dysmenorrhea, treats gastrointestinal disease,
Simultaneously can also anti-spasm and sterilization, effectively facilitate blood circulation, improve functional disturbance, set the mind at rest, anti-depression.
In the present invention, the typical but non-limiting mass fraction for example 0.1 of ginger essential oil, 0.12,0.15,0.18,
0.2,0.22,0.25,0.28,0.3,0.32,0.35,0.38 or 0.4 part.
Ginger essential oil is the clot that can eliminate accumulation, helps to improve internal moisture and the excessive state of body fluid, moreover it is possible to
Enough anti-inflammatory anti-itch.
In the present invention, the reason of selecting essential oil to prepare treatment dysmenorrhea drug as bulk pharmaceutical chemicals includes the following aspects：
(1) essential oil is attributed to health derived from natural：Plants essential oil is the intracorporal secondary metabolites of plant, opposite by molecular weight
Lesser simple compounds composition, has certain aromatic odor, the oily liquids substance that can be volatilized at normal temperature, have flavouring,
Sterilization, antiviral and anti-oxidant etc. bioactivity.There is the essential oil of " liquid golden " good reputation by green, naturally, safely, effectively
Etc. advantages received by more and more people；
(2) using instruction of Chinese Medicine theory as principle, formula is reasonable：Pass through angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi
Essential oil, P-Cymene and Lavender mutually cooperate with medication, and effect multiplication is more suitable for needed for illness, therapeutic effect is more preferably；
(3) safe and efficient：Essential oil is originated from draft, is the essence of effective ingredients in plant concentration, more efficiently, and essential oil is transdermal
Property it is good, work faster, effect is more preferable.
The compound essential oil preparation for the treatment of dysmenorrhea provided by the invention is using theory of traditional Chinese medical science as principle, and formula is reasonable, it then follows " palpus
Person, watching class can not be from " principle choose different essential oils, by angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil,
P-Cymene and Lavender coordinated not only have very strong fat-soluble and penetrating power, are quickly absorbed by body, and
And there is pungent perfume (or spice) to walk to alter, fragrant qi-regulating and promoting blood circulation and stopping pain effect, analgesic regulating menoxenia is significant, while can also pass through external use
Medicine, safe and efficient, simple and efficient, patient acceptance is higher, and compliance is stronger.
In the preferred embodiment of the present invention, the compound essential oil preparation for treating dysmenorrhea further includes according to the mass fraction
90-98 parts of base oil.
By the way that base oil is added in the compound essential oil preparation for the treatment of dysmenorrhea, so that the skin-friendly of essential oil composition is more
It is good, it more being capable of rapid osmotic skin.
In the preferred embodiment of the invention, treat in the compound essential oil preparation of dysmenorrhea, base oil it is typical but non-
Restrictive mass fraction for example 90,90.5,91,91.5,92,92.5,93,93.5,94,94.5,95,95.5,96,96.5,
97,97.5 or 98 parts.
In present invention further optimization embodiment, base oil be selected from Sweet Almond Oil, He Baba oil, grape seed oil or
At least one of wheat-germ oil, preferably SIMMONDSIA CHINENSIS SEED OIL.
Due to Sweet Almond Oil neutrality non-greasy, there is good skin-friendly, can moisten and soften skin quality, therefore, selects
Oily better effect based on Sweet Almond Oil.
In the preferred embodiment of the present invention, angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, folium artemisiae argyi
Essential oil, Lavender, Geranium Essential, Basil Essential and ginger essential oil respectively by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the root bark of tree peony, rhizoma cyperi, folium artemisiae argyi,
It extracts to obtain by steam distillation in lavender, fish pelargonium, sweet basil and ginger.
In another preferred implementation of the invention, above-mentioned various essential oils can also be extracted by supercritical extraction
It arrives.
By steam distillation be prepared angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene,
Lavender, Geranium Essential, Basil Essential and ginger essential oil, so that various drug essential oils are safer.
In the preferred embodiment of the present invention, it further includes pharmaceutically acceptable for treating the compound essential oil preparation of dysmenorrhea
Auxiliary material.
By the way that pharmaceutically acceptable auxiliary material is added in the compound essential oil preparation for the treatment of dysmenorrhea, so that preparation can be made
At different dosage forms, meet the use needs of patient.
In present invention further optimization embodiment, auxiliary material includes excipient, binder, filler, lubricant, resists
At least one of oxidant or thickener.
In the preferred embodiment of the present invention, treat the essential oil agent of dysmenorrhea dosage form be external preparation, pass through by
The compound essential oil preparation for treating dysmenorrhea is set as external preparation, safer convenient, avoid Long-term taking medicine and caused by drug resistance
With the side effects such as hepatotoxicity wind agitation.
In the preferred embodiment of the present invention, the compound essential oil preparation for treating dysmenorrhea is essential oil agent, patch, emulsifiable paste
Agent, micro emulsion gels or suspension.
According to the second aspect of the invention, the present invention provides a kind of preparation sides of compound essential oil preparation for treating dysmenorrhea
Method includes the following steps：By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, day
Zhu Kui essential oil, Basil Essential and ginger essential oil and optional base oil are uniformly mixed to arrive the compound essential oil system for the treatment of dysmenorrhea
Agent.
The preparation method simple process of the compound essential oil preparation for the treatment of dysmenorrhea provided by the invention, easy to operate, Neng Goushi
For industrialized production, production efficiency is improved.
In the preferred embodiment of the present invention, in the compound essential oil preparation of preparation treatment dysmenorrhea, by tanquedate
Oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, Basil Essential and ginger extract
Oil sequentially adds in base oil, is uniformly mixed, and obtains the compound essential oil preparation for the treatment of dysmenorrhea.
In present invention further optimization embodiment, base oil is placed in suitable container, sequentially adds Radix Angelicae Sinensis
Essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, Basil Essential and ginger
Essential oil after sufficiently shaking up, obtains the compound essential oil preparation for the treatment of dysmenorrhea, spare after closed preservation.
According to the third aspect of the present invention, the present invention provides the application method of above-mentioned treatment dysmenorrhea essential oil composition,
Include the following steps：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel Yu the lower three cun of underbellies of navel
?.
The compound essential oil preparation for the treatment of dysmenorrhea provided by the invention is safer convenient by smearing administration in vitro, avoids
The side effects such as drug resistance and hepatotoxicity wind agitation caused by long-term endo-medicine.
Technical solution provided by the invention is further described below with reference to embodiment and comparative example.
Embodiment 1
A kind of compound essential oil preparation for treating dysmenorrhea is present embodiments provided, including following component according to the mass fraction：
1 part of angelica essential oil, 1.5 parts of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.7 part of P-Cymene, lavender essence
0.8 part of oil, 0.2 part of Geranium Essential, 0.5 part of Basil Essential, 0.3 part and 94 parts of SIMMONDSIA CHINENSIS SEED OIL of ginger essential oil, above-mentioned each component
The sum of be 100 parts.
Embodiment 2
A kind of compound essential oil preparation for treating dysmenorrhea is present embodiments provided, including following component according to the mass fraction：
3 parts of angelica essential oil, 0.6 part of Rhizoma Chuanxiong essential oil, 0.4 part of root bark of tree peony essential oil, 0.25 part of rhizoma cyperi essential oil, 0.3 part of P-Cymene, lavender essence
0.45 part of oil, 0.4 part of Geranium Essential, 0.4 part of Basil Essential, 0.2 part and 94 parts of SIMMONDSIA CHINENSIS SEED OIL of ginger essential oil, above-mentioned each component
The sum of be 100 parts.
Embodiment 3
A kind of compound essential oil preparation for treating dysmenorrhea is present embodiments provided, including following component according to the mass fraction：
1.5 parts of angelica essential oil, 1.2 parts of Rhizoma Chuanxiong essential oil, 0.4 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.2 part of P-Cymene, lavender
It is 0.8 part of essential oil, 0.4 part of Geranium Essential, 0.3 part of Basil Essential, 0.3 part and 94.5 parts of SIMMONDSIA CHINENSIS SEED OIL of ginger essential oil, above-mentioned each
The sum of component is 100 parts.
Embodiment 4
A kind of compound essential oil preparation for treating dysmenorrhea is present embodiments provided, including following component according to the mass fraction：
2 parts of angelica essential oil, 1 part of Rhizoma Chuanxiong essential oil, 0.45 part of root bark of tree peony essential oil, 0.35 part of rhizoma cyperi essential oil, 0.3 part of P-Cymene, lavender essence
0.5 part of oil, 0.3 part of Geranium Essential, 0.3 part of Basil Essential, 0.4 part and 94.5 parts of SIMMONDSIA CHINENSIS SEED OIL of ginger essential oil, above-mentioned each group
/ and be 100 parts.
Embodiment 5
A kind of compound essential oil preparation for treating dysmenorrhea is present embodiments provided, including following component according to the mass fraction：
2.5 parts of angelica essential oil, 0.7 part of Rhizoma Chuanxiong essential oil, 0.5 part of root bark of tree peony essential oil, 0.3 part of rhizoma cyperi essential oil, 0.4 part of P-Cymene, lavender
0.6 part of essential oil, 0.35 part of Geranium Essential, 0.35 part of Basil Essential and 0.3 part and 94 parts of SIMMONDSIA CHINENSIS SEED OIL of ginger essential oil are above-mentioned each
The sum of component is 100 parts.
Embodiment 6
The preparation method for present embodiments providing a kind of compound essential oil preparation for treating dysmenorrhea, includes the following steps：By lotus
Lotus bar oil is placed in suitable container, sequentially add angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and
Lavender sufficiently shakes up, closed preservation, obtains the compound essential oil preparation for the treatment of dysmenorrhea.
Comparative example 1
This comparative example provides a kind of ibuprofen capsule.
Comparative example 2
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Geranium Essential, Basil Essential and ginger essential oil is not added, and base oil is 95 parts.
Comparative example 3
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Geranium Essential is not added, and base oil is 94.35 parts.
Comparative example 4
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Basil Essential is not added, and base oil is 94.35 parts.
Comparative example 5
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, ginger essential oil is not added, and base oil is 94.3 parts.
Comparative example 6
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Geranium Essential and Basil Essential are not added, and base oil is 94.7 parts.
Comparative example 7
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Geranium Essential and ginger essential oil are not added, and base oil is 94.65 parts.
Comparative example 8
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, the difference of this comparative example and embodiment 5
It is, Basil Essential and ginger essential oil are not added, and base oil is 94.65 parts.
Comparative example 9
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, including following component according to the mass fraction,
4 parts of angelica essential oil, 0.3 part of Rhizoma Chuanxiong essential oil, 0.2 part of root bark of tree peony essential oil, 0.2 part of rhizoma cyperi essential oil, 0.1 part of P-Cymene, lavender essence
0.2 part of oil, 0.8 part of Geranium Essential, 0.1 part of Basil Essential, 0.1 part of ginger essential oil and 94 parts of SIMMONDSIA CHINENSIS SEED OIL.
The difference of this comparative example and embodiment 5 is that the content of each essential oil component is different.
Comparative example 10
This comparative example provides a kind of compound essential oil preparation for treating dysmenorrhea, including following component according to the mass fraction,
0.5 part of angelica essential oil, 2 parts of Rhizoma Chuanxiong essential oil, 0.8 part of root bark of tree peony essential oil, 0.5 part of rhizoma cyperi essential oil, 0.1 part of P-Cymene, lavender essence
1.1 parts of oil, 0.1 part of Geranium Essential, 0.1 part of Basil Essential, 0.8 part of ginger essential oil and 94 parts of SIMMONDSIA CHINENSIS SEED OIL.
The difference of this comparative example and embodiment 5 is that the content of each essential oil component is different.
Test example 1
Mice clinical test is carried out to each embodiment and comparative example, to measure different groups for the therapeutic effect of dysmenorrhea.
1.1 material
1.1.1 animal
Healthy adult female Wistar rats, cleaning grade, weight 180-200g.
1.1.2 reagent and material
Ibuprofen granule；Rat blood serum IFN- kit；IL-4ELISA kit；The examination of P of Rats GF2 enzyme linked immunosorbent detection
Agent box；L-arginine methyl esters (L-NAME) and Rockwell liquid (Locke's solu-tion)；
1.1.3 instrument
MacLab/4e channel polygraph；
1.2 mouse analgesic tests
1.2.1 pain model in mice is established using 55 DEG C of thermostimulations
Magnetic mouse is placed on the constant temperature hot-plate instrument for being preheating to 55 DEG C, to lick metapedes as pain reaction, is to lick metapedes
Pain reaction, to there is licking incubation period of metapedes as the mean of pain threshold 2 threshold of pains using before medicine as the basic threshold of pain.
1.2.2 influence of the measurement essential oil composition to mouse pain threshold
The mouse for choosing Basic Pain Threshold value before being administered qualified (threshold of pain is greater than 5s, is less than 30s), is randomly divided into 16 groups, every group
10, after patch is respectively prepared in the drug of embodiment 1-5 and comparative example 1-10 the treatment dysmenorrhea provided, 1-15 group is given,
Middle 1-5 group gives the compound essential oil (3.2g/kg) of embodiment 1-5 group offer, and 6-15 group gives ibuprofen granule (0.06g/kg)
The treatment dysmenorrhea drug that comparative example 1-10 group provides, the 16th group is blank control group, gives same dosage distilled water, records 16 respectively
Group mouse reaction, sees that the results are shown in Table 1：
The pain threshold of 22 groups of mouse after table 1 is administered
1-5 group and 16 groups of comparison can be seen that the compound essential oil system for the treatment dysmenorrhea that embodiment 1-5 is provided from table 1
Agent can significantly improve the threshold value of mouse, this illustrates that the compound essential oil preparation for the treatment of dysmenorrhea provided by the invention has apparent stop
Pain effect.
The 6th group and the 16th group of comparison can be seen that the brufen group threshold of pain and blank control group and anticipate without statistics from table 1
Justice.
From table 15 groups and 7-15 group comparison as can be seen that the treatment dysmenorrhea that embodiment 5 provides compound essential oil system
Agent by the angelica essential oil of extra fine quality number, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender,
Geranium Essential, Basil Essential and ginger essential oil coordinated, more preferably to the analgesic effect of mouse.
1.3 rat analgesic experiments
1.3.1 rat dysmenorrhea model is established using oxytocin method
Using dysmenorrhea model Isolated Rat Uterus smooth muscle contraction amplitude, frequency as index, embodiment 1-5 and comparative example are evaluated
Influence of the drug that 1-16 is provided to the smooth musculation of rat uterus
1.3.2 experimental method
The female sd inbred rats that oxytocin induces dysmenorrhea model are randomly divided into 16 groups, every group 10, respectively 1-16 group,
In the 16th group be blank control group, in addition to the 16th group, other rats daily be subcutaneously injected diethylstilbestrol 2mg/kg, continuous 10
It.Since subcutaneous injection diethylstilbestrol the 6th day, 1-5 group gave the embodiment 1-5 compound essential oil preparation patch of offer respectively,
6-15 group gives patch made of the drug of comparative example 1-10 offer respectively.16 groups of injection same volume distilled water, continuous 5 days.End
Oxytocin 20U/kg is injected intraperitoneally in 1h after secondary administration.Immediate record rat occur pain reaction (writhing response) incubation period,
Writhing number in 30min calculates the inhibiting rate of writhing number.Writhing number inhibiting rate=(model group writhing number-administration group
Writhing number)/model group writhing number × 100%.PGF2 in rat blood serumαThe above-mentioned rat of assay, after injecting oxytocin
30min, etherization, abdominal vein takes blood, after processing, measures PGF2 in each group rat blood serumαContent.Above-mentioned model simultaneously
After animal takes blood, rat uterus is taken out rapidly, is placed in cold Rockwell liquid and cleans, and is taken every side cornua uteri middle section 2cm, is fixed on and fills
In the thermostatic bath of 10mL Rockwell liquid, on the tonotransducer that is connected with MecLab/4e.Solution temperature is 37.5- in bath
38 DEG C, constant is passed through 95%O2+ 5%CO2Mixed gas.It adjusts micro actuator and adds preload 1g, balance 40min, restore certainly to uterus
The rhythm and pace of moving things is sent out, after contraction frequency and amplitude stabilization, records the contraction frequency and amplitude in groups of animals uterus.
Influence of 2 drug of table to rat model
Note:Compared with blank control group:* P < 0.05；* P < 0.01
The compound essential oil preparation that 1-5 group can be seen that embodiment 1-5 offer with the 16th group of blank from table 2 can be shown
The incubation period for extending rat pain is write, the writhing number of rat is reduced, this illustrates that the compound essential oil preparation that embodiment 1-5 is provided has
Significant analgesic activity.
From 1-5 group and 6 groups of comparison as can be seen that the analgesic effect and cloth of the compound essential oil preparation that embodiment 1-5 is provided
Ibuprofen particle is suitable.
From the comparison of 1-5 group and 7-15 group as can be seen that the compound essential oil preparation for the treatment dysmenorrhea that embodiment 1-5 is provided is logical
Cross angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, the Lavender, India of extra fine quality number
Certain herbaceous plants with big flowers essence, Basil Essential and ginger essential oil coordinated, more preferably to the analgesic effect of rat.
3 drug of table is to PEG2 in Isolated Rat Uterus contraction frequency and amplitude and serumαInfluence
From table 3 it is observed that the uterine myometrium frequency of 1-5 group rat is substantially less than 16 groups, PGF2αIt is significant low
In 16 groups, this illustrates that the compound essential oil preparation that embodiment 1-5 is provided can significantly reduce oxytocin and receive to rat uterus smooth muscle
The influence of contracting inhibits PEG2 in rat bodyαSynthesis or release, reduce pain.
By 1-5 group with 6 groups comparison as can be seen that embodiment 1-5 provide essential oil composition to smooth muscle contraction
Inhibitory effect is a little higher than and ibuprofen capsule.
From the comparison of 1-5 group and 7-15 group as can be seen that the compound essential oil preparation for the treatment dysmenorrhea that embodiment 1-5 is provided is logical
Cross angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, the Lavender, India of extra fine quality number
Certain herbaceous plants with big flowers essential oil, Basil Essential and ginger essential oil coordinated more can significantly reduce oxytocin to the shadow of rat uterus smooth muscle contraction
It rings, inhibits PEG2 in rat bodyαSynthesis or release, reduce pain.
Test example 2
Choosing has female patient 82 of dysmenorrhea history, and the age 17-38 years old, experimental group 45, control group 37, experimental group
With control group patient on age, the course of disease and pain degree no significant difference (P>0.05) it, is comparable, wherein testing component
The essential oil composition of the offer of embodiment 5 is not given, and control group gives equal amount of distilled water, and measures record observation reaction and refer to
Mark, as a result as shown in Table 4-6.
The pretherapy and post-treatment menses prostaglandin (PGF2 of table 4α) horizontal comparison (x ± s, pg/mL)
| Number of cases (people) | Before treatment | After treatment | |
| Experimental group (embodiment 5) | 45 | 465.4±51.76 | 351.2±53.42 |
| Control group (distilled water) | 37 | 472.7±51.4 | 430.81±35.24 |
The comparison of experimental group and control group can be seen that experimental group from table 4 can significantly reduce PGF2 after the treatmentα,
This illustrates that the essential oil composition that experimental group provides has therapeutic effect to human body dysmenorrhea.
The pretherapy and post-treatment erythrocyte sedimentation rate numerical value of table 5 compares (mm/h)
| Number of cases (people) | Before treatment | After treatment | |
| Experimental group (embodiment 5) | 45 | 24.57±5.12 | 11.32±6.24 |
| Control group (distilled water) | 37 | 23.91±5.22 | 19.12±6.35 |
As can be seen from Table 5, the essential oil composition that embodiment 5 provides can increase blood perfusion amount, improve microcirculation,
Coordinate uterine function activity, alleviates dysmenorrhea.
6 patient clinical efficacy data table (example %) of table
As can be seen from Table 6, the essential oil composition that embodiment 5 provides total effective rate in using crowd reaches 95.6%,
This illustrates that the essential oil composition can adjust prostate levels in blood to alleviate smooth muscle tone state, and can dredge through adjusting blood to make
Uterus microcirculating state is effectively improved.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, those skilled in the art should understand that：Its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1, which is characterized in that including according to the mass fraction
Following component：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil,
0.25-0.8 parts of P-Cymene, 0.4-1 parts of Lavender, 0.2-0.5 parts of Geranium Essential, 0.2-0.5 parts of Basil Essential and
0.1-0.4 parts of ginger essential oil.
2. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1, which is characterized in that including according to the mass fraction
Following component：1.5-2.5 parts of angelica essential oil, 0.7-1.2 parts of Rhizoma Chuanxiong essential oil, 0.4-0.6 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil 0.25-
0.4 part, 0.2-0.7 parts of P-Cymene, 0.45-0.8 parts of Lavender, 0.3-0.4 parts of Geranium Essential, Basil Essential 0.3-
0.4 part and ginger essential oil 0.2-0.3 parts.
3. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1, which is characterized in that including according to the mass fraction
Following component：2-2.5 parts of angelica essential oil, 0.7-1 parts of Rhizoma Chuanxiong essential oil, 0.45-0.55 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil 0.25-
0.35 part, 0.2-0.5 parts of P-Cymene, 0.45-0.7 parts of Lavender, 0.3-0.4 parts of Geranium Essential, Basil Essential
0.3-0.4 parts and ginger essential oil 0.2-0.3 parts.
4. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-3, which is characterized in that further include by matter
90-98 parts of base oil for measuring number meter, preferably 91.4-96.7 parts, be still more preferably 92-96 parts；
Preferably, the base oil is selected from least one of Sweet Almond Oil, He Baba oil, grape seed oil or wheat-germ oil,
Preferably SIMMONDSIA CHINENSIS SEED OIL.
5. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-3, which is characterized in that angelica essential oil,
Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, Basil Essential and ginger essential oil
Respectively by being extracted in Radix Angelicae Sinensis, Rhizoma Chuanxiong, the root bark of tree peony, rhizoma cyperi, folium artemisiae argyi, lavender, fish pelargonium, sweet basil and ginger by steam distillation
It obtains.
6. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-3, which is characterized in that further include pharmacy
Upper acceptable auxiliary material；
Preferably, the auxiliary material includes in excipient, binder, filler, lubricant, antioxidant, preservative or thickener
At least one.
7. the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-3, which is characterized in that the preparation
Dosage form is external preparation；
Preferably, the dosage form of the preparation is essential oil agent, patch, cream, micro emulsion gels or suspension.
8. the preparation method of the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-7, which is characterized in that
Include the following steps：By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, fish pelargonium
Essential oil, Basil Essential, ginger essential oil and optional base oil are uniformly mixed to arrive the compound essential oil preparation for the treatment of dysmenorrhea.
9. the preparation method of the compound essential oil preparation for the treatment of dysmenorrhea according to claim 8, which is characterized in that including as follows
Step：
By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender, Geranium Essential, sweet basil
Essential oil, ginger essential oil sequentially add in base oil, are uniformly mixed, and obtain the compound essential oil preparation for the treatment of dysmenorrhea.
10. the application method of the compound essential oil preparation for the treatment of dysmenorrhea according to claim 1-7, feature exist
In including the following steps：In menalgia or 3-7 days before menstrual period, compound essential oil preparation is applied to navel and lower three cun of navel
The Guanyuan point of underbelly.
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