CN107595947A - A kind of plant essential oil composition and preparation method, application for being used to treat dysmenorrhoea - Google Patents
A kind of plant essential oil composition and preparation method, application for being used to treat dysmenorrhoea Download PDFInfo
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- CN107595947A CN107595947A CN201710085718.9A CN201710085718A CN107595947A CN 107595947 A CN107595947 A CN 107595947A CN 201710085718 A CN201710085718 A CN 201710085718A CN 107595947 A CN107595947 A CN 107595947A
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Abstract
The invention discloses a kind of plants essential oil and preparation method for being used to treat dysmenorrhoea.Its technical field belongs to the applied technical field of plant extracts.A kind of plant essential oil composition for being used to treat dysmenorrhoea, it is characterised in that：Described plants essential oil is made up of the component of following masses part：Chinese herbaceous peony flower essential oil, Lavender, P-Cymene, the wooden fruit essential oil of breast, fully mix, obtain that mixed liquor A is mutually standby, and configuration Chinese medicine compound prescription ethanol solution be B phases, and A is added in B phases, finished product is obtained after abundant mixing；The Chinese medicine compound prescription ethanol solution is prepared by cassia twig, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and small radix bupleuri.The beneficial effect of invention is to reach the purpose for the treatment of dysmenorrhoea using the high volatile and high osmosis of essential oil and the synergy of a variety of essential oils.
Description
Technical field
The present invention relates to a kind of plants essential oil for dysmenorrhoea, belong to the applied technical field of plant extracts.
Background technology
Dysmenorrhoea is one of most common gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with
The soreness of waist or other uncomfortable, serious symptom influence quality of life persons.Dysmenorrhoea is divided into primary dysmenorrhea and the class of Secondary cases two, primary pain
Through referring to dysmenorrhoea of the reproductive organs without organic disease, dysmenorrhoea more than 90% is accounted for；Acquired dysmenorrhea refers to is drawn by pelvic cavity organic disease
The dysmenorrhoea risen.Clinical manifestation is：1. primary dysmenorrhea is common in puberty, often fallen ill after first menses in 1~2 year；2. pain is more
Since after menstrual onset, premenstrual 12 hours are appeared in earliest, and to pass through, pain on the 1st is most violent, alleviates after continuing 2~3.
Pain is often in spastic, on lower abdomen pubis, can be radiated to lumbosacral region and femoribus internus；3. can be with Nausea and vomiting, abdomen
The symptom such as rush down, be dizzy, be weak, complexion is turned white, is in a cold sweat when serious.
The reason for dysmenorrhoea, mainly has：(1) generation of primary dysmenorrhea mainly with endometrium Prostaglandin during menstruation
Increase relevant.The main reason for PGF2 alpha contents cause dysmenorrhoea when raising.PGF2 alpha contents height can cause the too strong receipts of uterine smooth muscle
Contracting, vasopasm, cause uterus ischemic, anoxia state and there is dysmenorrhoea.(2) vasopressing, endogenous oxytocin and β-
The increase of the materials such as endorphin.(3) spirit, neural factors.
At present, in addition to psychotherapy, main drug treatment is：(1) prostaglandin synthase inhibitor is commonly used
Medicine have brufen, Ketoprofen, Meclofenamic Acid, Diclofenac etc..(2) oral contraceptive is applied to require the dysmenorrhoea of contraception
Women, it is efficient up to more than 90%.These above-mentioned treatment methods are single, for the women of child-bearing age, can only use analgesia therapy more
Method.However, long-term use of analgestic, can cause drug resistance, it can only be eased pain by escalated dose, drug therapy dysmenorrhoea is simply weighed
Suitable meter.Therefore, it is necessary to find the more efficient method for the treatment of dysmenorrhoea.
Essential oil can say be plant hormone, it possesses and mankind's identical forms material and life energy.Different essences
Oil can be combined with each other, and mix the fragrance oneself liked, and will not destroy the speciality of essential oil, make the with better function of essential oil on the contrary.
Essential oil selected by the present invention, which has, adjusts endocrine organ, promotion hormone secretion, promotion cell metabolism and cytothesis,
Anti-inflammation, anti-oxidant, anti-aging, antiviral, pre anti-communicable diseases, the function such as anti-inflammation, anti-spasm.And some essential oil energy, allow
The physiology and psychological activity of human body, obtain good development.
Essential oil molecule is superfine, and penetration is high, so the extremely effective disengaging body of energy, and will not leave behind any toxin.Root
Show according to the study, essential oil will not as chemicals, remain in vivo, it be by just urinate, perspire, exhale and be discharged,
For the people of normal health, the time of discharge needs three to six hours, even if for unsound people, also only needs 14
Hour.For broad sense, the manufacturing works of plant inherently chemical substance.When essential oil is entered in human body, we, which are equal to, takes
The elite of plant.Therefore it is that can make tissue is strongr to have more vigor using essential oil that we are predicable.
Various essential oils are combined and coordinate Chinese medical extract by the present invention, are prepared into the plants essential oil for treating dysmenorrhoea and are combined
Thing, so as to overcome existing the defects for the treatment of dysmenorrhoea method.Pure plant essential oil compound formulation prepared by the present invention, does not add artificial system
Agent, for treating dysmenorrhoea.
The content of the invention
To solve the problems, such as that prior art treats dysmenorrhoea, the present invention provides a kind of pure plant essential oil compound formulation, had
Regulation regulation endocrine and analgesic effect, so as to play a part for the treatment of dysmenorrhoea.
The present invention is realized by following technical proposal：
A kind of plant essential oil composition for being used to treat dysmenorrhoea, it is characterised in that：Described plants essential oil is by following masses
The component composition of part：Chinese herbaceous peony flower essential oil, Lavender, P-Cymene, the wooden fruit essential oil of breast, fully mix, obtain mixed liquor A phase
Standby, configuration Chinese medicine compound prescription ethanol solution is B phases, and A is added in B phases, and finished product is obtained after fully mixing；The Chinese medicine compound prescription
Ethanol solution is prepared by cassia twig, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and small radix bupleuri.The preparation side of the plant essential oil composition
Method, it is characterised in that：Step includes：
By volume parts, 6~8 parts of Chinese herbaceous peony flower essential oil, 8~10 parts of Lavender, 3~5 parts of P-Cymene, breast wood are weighed
5~7 parts of fruit essential oil, and 50 parts of 65% Chinese medicine compound prescription ethanol solution are added separately to seal in mixing tank, and normal temperature stirs below
Side is added, and stirring 5 minutes is further continued for after adding；The Chinese medicine compound prescription ethanol solution is prepared by following steps：By weight
Number meter, by cassia twig, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and each 15 parts of small radix bupleuri, 65% ethanol soaked overnight of 10 times of volumes, filtering
Obtained filtrate；High-speed stirred 5 minutes, is well mixed laggard after the big mixing tank of essential oil mixed liquor addition that will be sealed in mixing tank
Row is filling, filling while stirring when filling, and product is can obtain after packaged.
The composition is preparing the application in treating dysmenorrhoea medicine.
The composition, it is characterised in that：The plants essential oil treatment dysmenorrhoea is by adjusting regulation endocrine and analgesia
What effect was realized.
The composition, it is characterised in that：Dysmenorrhoea, including liniment, spray, lotion can be treated by multiple pathways.
Beneficial effect：
The present invention is reached using the high volatile and high osmosis and the synergy of a variety of essential oils and Chinese medicine of essential oil, is overcome
Long-term use of analgestic can cause drug resistance, realize the effect for the treatment of dysmenorrhoea.
The effect of the present invention is that (1) has and adjusts endocrine effect；(2) there is analgesic effect；(3) it is long-term use of
Do not change vagina Inner acid-base balance, no resistance to the action of a drug, have no toxic side effect, only have extremely slight stimulation to vagina mucosa；(4)
So far non-Fa Now have taboo crowd, and allergy effect is also found no to allergic constitution crowd；(5) while there is treatment and health care
Effect, there is certain adjustment effect to female reproductive system and body and mind.
Embodiment：
Essential oil of the present invention is purchased from AFU A Fu essential oils.
Embodiment 1
Preparation method of the present invention：By volume parts, 6 parts of Chinese herbaceous peony flower essential oil, 8 parts of Lavender, P-Cymene 3 are weighed
Part, wooden 5 parts of the fruit essential oil of breast, and 50 parts of 65% Chinese medicine compound prescription ethanol solution are added separately to seal in mixing tank, and normal temperature is following
Stir side to add, stirring 5 minutes is further continued for after adding；The Chinese medicine compound prescription ethanol solution is prepared by following steps：By weight
Number meter is measured, by cassia twig, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and each 15 parts of small radix bupleuri, 65% ethanol soaked overnight of 10 times of volumes,
The filtrate being filtrated to get；High-speed stirred 5 minutes, is well mixed after the big mixing tank of essential oil mixed liquor addition that will be sealed in mixing tank
After carry out it is filling, it is filling while stirring when filling, it is packaged after i.e. can obtain product.
Embodiment 2
The present embodiment presses mass fraction by Chinese herbaceous peony flower essential oil for the natural plant essential oils of dysmenorrhoea as different from Example 1
8 parts, 10 parts of Lavender, 5 parts of P-Cymene, 7 parts and 70 parts Chinese medicine compound prescription ethanol solution compositions of the wooden fruit essential oil of breast, other systems
Preparation Method is same as Example 1.
Embodiment 3
The present embodiment presses mass fraction by Chinese herbaceous peony flower essential oil for the natural plant essential oils of dysmenorrhoea as different from Example 1
7 parts, 9 parts of Lavender, 4 parts of P-Cymene, 6 parts and 74 parts Chinese medicine compound prescription ethanol solution compositions of the wooden fruit essential oil of breast, other systems
Preparation Method is same as Example 1.
Embodiment 4
Plant essential oil composition application test prepared by the present invention：
To begin from November, 2013, stop in by the end of December, 2014 to, public affairs department divides Do in the area such as Shaanxi, Shanxi, Yunnan, Shanghai,
To being tested by the precious disconnected patient present invention for women for determining dysmenorrhoea to clinical effectiveness, participate in total number of persons on probation is Fen Do
216, age 18-25.Application method is：The application method of liniment：Wiping navel Oculocutaneous during morbidity, 3 times/
Day, 4-6 times/day of severe patient.The application method of spray：During morbidity, the spray of patient's navel surrounding skin is directly directed at
Penetrate, 3 times/day, 4-6 times/day of severe patient.The method of lotion is：Put into this product 10ml in 1000ml warm water, soak foot, disease
2 times/day of the lighter, 3-4 times/day of severe one.
As a result show：Investigation is on probation and statistical result see the table below 1：
The clinical effectiveness test result of the present invention of table 1
The product of the investigation result display present invention has the effect of preferable to dysmenorrhoea, and average cure rate is 95.4%.It is one
The health products of the potential treatment dysmenorrhoea of kind.
Embodiment 5
The analgesic activity of plant essential oil composition prepared by embodiment 1：Pre-selection 50 has in 30 seconds the female of pain reaction big
Mouse.Rat is placed in whipping pain threshold detector, whipping test produces the light beam of some strength with baby spot, passes through lens focus
The tail of irradiation in rats carrys out induced pain, determine and record since irradiation to whipping reaction be pain threshold, survey 2 times, every 5min survey
Amount 1 time, observation index is used as using Rat Tall Flick.50 rats are randomly divided into 5 groups：High dose group, middle dose group, low dosage
Group, positive controls, model group, every group of l0 is only.Model group wipes injured afterbody according to 20 μ l/Kg dosage；Positive controls
Wipe the injured μ l/Kg morphine solutions of afterbody 5；High, normal, basic dosage group gives the plant essential oil composition 5 of the preparation of embodiment 1 respectively,
10,20 μ l/Kg wipe injured afterbody, and 20min determines tolerance time again after administration, if being taken immediately without pain reaction in rat 60s
Go out, calculated by 60s.Threshold of pain increase rate (%)=
As a result：Such as table 2.Compared with model group rats, the basic, normal, high dosage energy of plant essential oil composition of the preparation of embodiment 1
Conspicuousness improves the threshold of pain (P of rat<0.05).
The influence of plant essential oil composition prepared by the embodiment 1 of table 2 to Rat Tall Flick method analgesic test
*p<0.05, * * p<0.01 compared with model group
Embodiment 6
Evaluate influence of the plant essential oil composition of the preparation of embodiment 2 to estrogen secretion.Female ICR mice, random point
Into 3 groups：Blank group, positive group, plant essential oil composition group prepared by embodiment 1.Every group 10.Vagina administration 1 time daily, agent
Measure as physiological saline of the blank group according to 20 μ l/ only；The estrogen of the μ l/ of positive controls 5 only；Plant essence prepared by embodiment 1
10 μ of fluid composition group l/, continuous 10d.Respectively after last time is administered, eyeball takes blood, is detected using radioimmunology small
The content of estrogen in mouse blood plasma.
As a result show：Such as table 3.Plant essential oil composition energy conspicuousness prepared by embodiment 2 promotes in mice plasma, with sky
White group is compared, and has significant difference (p ＜ 0.01), effect is better than positive estrogen group.
The shadow of plant essential oil composition prepared by the embodiment 1 of table 3 to plasma estrogens content
Ring
| Estradiol content (pmol/L) | |
| Blank group | 245.5±34.8 |
| Estrogen | 478.1±89.6* |
| The plants essential oil of embodiment 1 | 689.0±108.5** |
Embodiment 7
Skin irritation test includes acute skin irritation experiment and multiple skin irritation test.
Foundation《Cosmetics health specification (2007 editions)》, acute skin is carried out to plant essential oil composition prepared by embodiment 1
Skin irritation test and multiple skin irritation test.
(1) acute skin irritation test method：Take SD rats 10, about 24h before experiment, by rat back backbone both sides
Hair is cut, and can not damage epidermis, the left and right each about 3cm × 3cm of unhairing scope.Plant essential oil composition prepared by Example 1 is about
0.5mL is coated directly on the skin of side, then with two layers of gauze (2.5cm × 2.5cm) and one layer of glassine paper or the like covering,
Fixed again with nonirritant adhesive plaster and bandage.Opposite side skin is as control.Using blocking test, the application time is 4h.
The plant essential oil composition of the residual preparation of embodiment 1 is removed after off-test with warm water.Removing the plant of the preparation of embodiment 1 respectively
1,24,48 and 72h observation rats after thing essential oil composition smear the erythema and oedema response situation of area skin.
As a result show, remove embodiment 1 prepare plant essential oil composition after 1,24,48 and 72h rat skins do not go out
Existing erythema and oedema phenomenon.As can be seen here, the plant essential oil composition that prepared by embodiment 1 is to no skin irritation.
(2) multiple skin irritation test method：Take SD rats 10, about 24h before experiment, by rat back backbone both sides
Hair is cut, and unhairing scope is respectively 3cm × 3cm, application area 2.5cm × 2.5cm.Plants essential oil group prepared by Example 1
Compound about 0.5mL is coated directly on the skin of side, and opposite side applies solvent as control, smears 1 time daily, continuously smears 14d.From
Start within second day, cropping is answered before smearing every time, the plant essential oil composition of the residual preparation of embodiment 1 is removed with water.After one hour
Observe erythema and oedema response situation that rat smears area skin.
As a result show, after plant essential oil composition prepared by embodiment 1 is coated on rat side skin in continuous 14 days,
Do not occur erythema and oedema phenomenon.As can be seen here, the plant essential oil composition that prepared by embodiment 1 is to no skin irritation.
Claims (5)
- A kind of 1. plant essential oil composition for being used to treat dysmenorrhoea, it is characterised in that：Described plants essential oil is by following masses part Component composition：Chinese herbaceous peony flower essential oil, Lavender, P-Cymene, the wooden fruit essential oil of breast, fully mix, it is mutually standby to obtain mixed liquor A With configuration Chinese medicine compound prescription ethanol solution is B phases, and A is added in B phases, and finished product is obtained after fully mixing；The Chinese medicine compound prescription second Alcoholic solution is prepared by cassia twig, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and small radix bupleuri.
- 2. the preparation method of the plant essential oil composition, it is characterised in that：Step includes：By volume parts, 6 ~ 8 parts of Chinese herbaceous peony flower essential oil, 8 ~ 10 parts of Lavender, 3 ~ 5 parts of P-Cymene, the wooden fruit essential oil 5 of breast are weighed ~ 7 parts, and 50 parts of 65% Chinese medicine compound prescription ethanol solution is added separately to seal in mixing tank, adds, adds while stirring under normal temperature Stirring 5 minutes is further continued for after complete；The Chinese medicine compound prescription ethanol solution is prepared by following steps：Count in parts by weight, by osmanthus Branch, purple perilla, mulberry leaf, the root of herbaceous peony, corydalis tuber and each 15 parts of small radix bupleuri, 65% ethanol soaked overnight of 10 times of volumes, the filter being filtrated to get Liquid；The essential oil mixed liquor in mixing tank will be sealed and add high-speed stirred 5 minutes after big mixing tank, carried out after well mixed it is filling, It is filling while stirring when filling, it can obtain product after packaged.
- 3. the composition is preparing the application in treating dysmenorrhoea medicine.
- 4. the composition, it is characterised in that：The plants essential oil treatment dysmenorrhoea is made by adjusting regulation endocrine and analgesia With realization.
- 5. the composition, it is characterised in that：Dysmenorrhoea, including liniment, spray, lotion can be treated by multiple pathways.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815488A (en) * | 2018-08-10 | 2018-11-16 | 江西中医药大学 | Treat compound essential oil preparation of dysmenorrhea and preparation method thereof and application method |
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| CN105193951A (en) * | 2015-10-27 | 2015-12-30 | 张涛 | Chinese herbal medicine lavipeditum bag capable of relieving dysmenorrheal symptoms |
| CN106924657A (en) * | 2017-02-17 | 2017-07-07 | 云南同方科技有限公司 | A kind of plant essential oil composition and preparation method, application for treating senile vahinitis |
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Patent Citations (4)
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| CN101869610A (en) * | 2009-06-15 | 2010-10-27 | 嵇莓芳 | Wound medicament of acer truncatum essential oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108815488A (en) * | 2018-08-10 | 2018-11-16 | 江西中医药大学 | Treat compound essential oil preparation of dysmenorrhea and preparation method thereof and application method |
| CN108815488B (en) * | 2018-08-10 | 2021-06-08 | 江西中医药大学 | Compound essential oil preparation for treating dysmenorrhea and preparation method and using method thereof |
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