CN106581246A - Traditional Chinese medicine paste for treating hemorrhoids and preparation method thereof - Google Patents
Traditional Chinese medicine paste for treating hemorrhoids and preparation method thereof Download PDFInfo
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses traditional Chinese medicine paste for treating hemorrhoids. The traditional Chinese medicine paste comprises a traditional Chinese medicine composition, vegetable oil and a matrix. The traditional Chinese medicine composition comprises, by weight, 0.6 to 2.0 portions of phellodendron, 0.6 to 2.0 portions of coptis root, 0.6 to 2.0 portions of radix scutellariae, 0.6 to 2.0 portions of rhubarb, 0.6 to 2.0 portions of honeysuckle, 0.6 to 2.0 portions of radix sanguisorbae, 0.6 to 2.0 portions of Chinese gall and 0.3 to 1.0 portion of borneol. Vegetable oil is rapeseed oil, soybean oil or sesame oil. The matrix comprises one or more of albolene, beeswax, stearic acid, lanolin, hydrogenated vegetable oil, dimethicone, glycerol, gelatin, polyethylene glycol 4000 and polyethylene glycol 6000. The traditional Chinese medicine paste is prepared from common traditional Chinese medicines, has a cheap price, high infection resistance, a fast rate of eliminating swelling and alleviating pain, good curative effects and no toxic or side effect and is suitable for treatment on external hemorrhoid, internal hemorrhoid and mixed hemorrhoid and cure after a hemorrhoid operation.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of to treat Chinese medicinal ointment of hemorrhoid and preparation method thereof.
Background technology
The traditional Chinese medical science very early, according to literature record business's epoch summer can be traced back to the Cognitive Origin of " hemorrhoid ".Hemorrhoid are a kind of normal
See disease, frequently-occurring disease, all ages and classes all can occur with different sexes crowd, therefore often have saying for " hemorrhoid of ten people nine ".《Danxi's experiential therapy》Cloud：
" hemorrhoid person all because of this void of internal organs, wound rheumatism, interior intrinsic heat poison, so that falling under qi and blood, ties poly- anus, and place is stagnant not to be dissipated, and it is hemorrhoid to conflict
",《Yizong Jinjian》Also cloud：" hemorrhoid form and name also many as, the scorching source of not outer rheumatism ", it is indicated that internal organs weakness is the pathogenetic base of hemorrhoid
This factor, it is the pathogenetic major reason of hemorrhoid to experience rheumatism pathogenic dryness-heat.The traditional Chinese medical science thinks, with regard to the origin cause of formation of hemorrhoid, more by sitting, long
Stand, chronic diarrhea, long secret, chronic cough, or do one's utmost to bear a heavy burden, gestation fertility etc. causes qi and blood in length and breadth, foul smell hemostasis, streamer anus, lump formation due to accumulation of pathogens
Into hemorrhoid.Eating and drinking without temperance, overfeeding is pungent, production of dryness-heat in the interior, and gas is compeled blood stasis and swollen and ache.Doctor trained in Western medicine thinks, earns under exerting oneself during defecation, firmly lifts
Weight or cough, cause anus edge angiorrhoxis, and in subcutaneous formation enclosed mass, the superfluous skin hyperplasia of anus edge forms external piles to accumulation of blood.Excrement
Retention, stimulates local to cause inflammation, outside internal piles abjection anus, is clamped by sphincter, and venous return is obstructed, but arterial blood is still constantly defeated
Enter, the internal piles hyperemia of abjection, volume is constantly increased, until the arterial blood of input is pressed to cause blood stasis to be formed.This disease it is common go out
The big symptom of blood, pain, constipation etc. three, easily patient suffering and recurrence.
To the therapy of hemorrhoid based on external therapy, its unique non-operative treatment has bright the traditional Chinese medical science compared with the operative treatment of doctor trained in Western medicine
Aobvious advantage.Operative treatment technical requirements and costly, and Post operation easily occur pain, bleeding, infection, wound healing it is slow,
The complication such as anus edge oedema；And traditional Chinese medical science non-operative treatment can then avoid similar complication from occurring, in addition the method is simple to operate, again may be used
Mitigate patient's pain, be particularly well-suited to the patient of age, body void.Traditional Chinese medical science non-operative treatment be also at present treat operative treatment it is concurrent
The best approach of disease.Certainly, there is dosage inequality in such as smoked method, method of topical application, the turunda method of washing of Traditional Chinese Medicine non-operative treatment
Weighing apparatus, Different therapeutical effect is big, the defect such as patient medication inconvenience, poor compliance.Therefore, the Chinese medicine that exploitation facilitates patient to use controls hemorrhoid system
Agent is the inevitable choice that the traditional non-operative treatment of the traditional Chinese medical science is combined with modern Chinese herbal medicine preparation technique.
Famous and precious or resource scarcity Chinese medicine being used the prescriptions of traditional Chinese medicine of existing treatment hemorrhoid, such as more：Moschus, agalloch eaglewood, bear gall,
Dragon's blood, pangolin etc..At present, contain in mayinglong shexiang zhichuang ointments, bear's gall ointment and the anus Thailand sold on domestic market
Moschus, bear gall hemorrhoid spirit cream prescription uses bear gall, and jingwanhong soft plaster acne cream prescription uses dragon's blood and pangolin；Patents are such as
CN1546084A, CN102697836A, CN103071008A etc. also imitate one after another similar prescription.In addition, using drug effect to improve
Really, strengthen convergence to dispel rotten effect, or even the toxic herb material, such as CN1679722A such as the calomel mercurous chloride used in prescription, rouge and powder, silver-colored pearl.
To sum up, famous and precious or resource scarcity Chinese medicine is consumed in a large number, can at any time introduce that MED SUP is unbalance and its quality is unstable etc. can not
Control factor, stern challenge is caused to drug quality and price, and the use of the toxic traditional Chinese medicine material such as calomel mercurous chloride, rouge and powder, silver-colored pearl is even more
Patient is allowed to hang back, and the use of the strong medicinal material of blood-activating and qi-promoting power such as Moschus, dragon's blood, pangolin is not suitable for nursing period and pregnant yet
Phase patient, has further limited to promotion and application of the Chinese medicine in terms of hemorrhoid are controlled.
The content of the invention
The limitation existed based on background technology and deficiency, the invention provides a kind of Chinese medicinal ointment and its system for treating hemorrhoid
Preparation Method.The Chinese medicinal ointment prescription of the present invention adopts conventional, nontoxic, inexpensive Chinese medicine, the prescription to have anti-infective strong, pain relieving
The characteristics of detumescence is fast, quick-acting safe.Suitable for the treatment of external piles, internal piles, mixed hemorrhoid and hemorrhoid operation infectious-related complication, particularly
Apply to nursing period and pregnant patients.
A kind of Chinese medicinal ointment for treating hemorrhoid that the present invention is provided, its raw material includes：Chinese medicine composition, vegetable oil and base
Matter, Chinese medicine composition includes by weight：0.6～2.0 part of golden cypress, 0.6～2.0 part of the coptis, 0.6～2.0 part of the root of large-flowered skullcap, rheum officinale
0.6～2.0 part, 0.6～2.0 part of honeysuckle, 0.6～2.0 part of garden burnet, 0.6～2.0 part of Chinese gall, 0.3～1.0 part of borneol.
Preferably, vegetable oil is one or more compositions in soybean oil, rapeseed oil, sesame oil.
Preferably, matrix is albolene, beeswax, stearic acid, lanolin, hydrogenated vegetable oil, dimeticone, glycerine, bright
One or more compositions in glue, Macrogol 4000, Macrogol 6000.
Preferably, the weight ratio of Chinese medicine composition and vegetable oil is 1:2～6.
Preferably, the weight ratio of matrix and vegetable oil is 1:1～3.
Preferably, Chinese medicine composition includes by weight：1.0 parts of golden cypress, 1.0 parts of the coptis, 1.0 parts of the root of large-flowered skullcap, rheum officinale 1.0
Part, 1.0 parts of honeysuckle, 1.0 parts of garden burnet, 1.0 parts of Chinese gall, 0.5 part of borneol.
The preparation method of the Chinese medicinal ointment of the above-mentioned treatment hemorrhoid that the present invention is also proposed, comprises the steps：By golden cypress, Huang
Company, the root of large-flowered skullcap, rheum officinale, honeysuckle, garden burnet, Chinese gall are crushed, and are added and soak in vegetable oil 1～3h, are then heated to 80～110
DEG C, 1～3h is extracted, then it is warming up to 120～150 DEG C, 0.2～1h is extracted, to filter, filtrate is cooled to 70 DEG C～100 DEG C, adds base
Matter is well mixed, and is subsequently cooled to 40～80 DEG C, and the borneol of addition powder is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Wherein Chinese medicinal ointment can be ointment, paint.
The present invention adopts golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale, honeysuckle, garden burnet, Chinese gall and the taste medicinal material composition of borneol eight,
There is clearing away heat and loosing the bowels, hemostasis, swelling and pain relieving.Wherein golden cypress bitter, cold in nature；With heat-clearing and damp-drying drug, purging intense heat and detonicating, removing toxic substances
Treat effect of sore.Coptis bitter, it is cold in nature；There is clearing heat-fire, eliminating dampness, removing toxic substances.Root of large-flowered skullcap bitter, it is cold in nature；With heat-clearing
Purging intense heat, eliminating dampness removing toxic substances, hemostasis, antiabortive effect, have antibacterial, anti-inflammatory, anti-oxidant, resistance state concurrently and strengthen immunocompetence effect.
Rheum officinale bitter, it is cold in nature；Have functions that to attack stagnant, clearing away damp-heat, purging intense heat, cool blood, removing toxic substances.Garden burnet bitter, acid, puckery, cold nature；Tool
There are cooling blood and hemostasis, removing toxic substances sore, have hemostasis, antibacterial, antiviral and antiinflammatory action concurrently.Chinese gall taste is sour, puckery, cold in nature；
There is astringe the lung fall fire, relieving diarrhea with astringents, arrest sweating, hemostasis, hygroscopic sore.Honeysuckle is sweet, cold in nature；With clearing heat and detoxicating,
Effect of dispelling wind and heat from the body.Borneol taste is pungent, hardship, are slightly cold；There is inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.
Based on golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale, this four medicine is shared the medicinal material composition of the present invention, clearing heat and detoxicating, purging intense heat
The power of eliminating dampness is strong, assaults the main target " rheumatism pathogenic dryness-heat ", and eliminating evil is consolidated.In addition, being aided with Chinese gall, garden burnet strengthens convergence, anastalsis,
Strengthen radiating analgesic efficacy with honeysuckle, borneol again, it is to take stopgap measures that this four medicine is shared, for alleviating hemorrhoid symptom, mitigate patient
Pain.
Golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale, Chinese gall, garden burnet and honeysuckle used of the invention are domestic ecosystem road real estate
Medicinal material or the prepared slices of Chinese crude drugs, quality meets current edition Chinese Pharmacopoeia requirement.
The Chinese medicinal ointment Jing hospital clinicals research of the present invention, in March, 2014, in March, 2016, adds up treatment hemorrhoid patients
263 people, male 145 people, the people of female 118, the age is minimum 16 years old, and maximum 85 years old, the course of disease is most short 2 weeks, most long 15 years, wherein the people of external piles 83
(people of pregnant woman 8, the people of women breast-feeding their children 11), the people of internal piles 72 (people of pregnant woman 13, the people of women breast-feeding their children 7), the people of mixed hemorrhoid 57 (people of pregnant woman 6,
The people of women breast-feeding their children 6), the people of postoperative complications 51 (people of pregnant woman 3, the people of women breast-feeding their children 7), medication 1～3 week cures 205, shows
, effective 20, invalid 0, there is no bad reaction in effect 38, patient's compliance is good during medication.Present invention treatment has
Efficiency 100%.
Relative to prior art, the present invention has advantages below：
1st, medicinal material of the present invention is conventional cheap medicinal material or the prepared slices of Chinese crude drugs, and ample supply of commodities on the market, quality is guaranteed；
2nd, Chinese medicinal ointment therapeutic domain of the invention is wide, it is adaptable to which all kinds hemorrhoid such as external piles, internal piles, mixed hemorrhoid are controlled
Treat, be more suitable for the treatment of hemorrhoid operation infectious-related complication；
3rd, Chinese medicinal ointment safe without toxic side effect of the invention, good patient compliance is adapted to crowd extensively, is particularly suited for feeding
Newborn phase and pregnant patients；
4th, Chinese medicinal ointment of the invention is rapid-action, and pain relieving, hemostasis, detumescence effect are good, and medication can stop blooding for 3 minutes, 15 points
Clock eliminates pain, starts within 60 minutes detumescence, and a drug can maintain curative effect 6h, medication lump to be completely eliminated within 1～3 week, control
Cycle is short is treated, treated effect is high.
Specific embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment 1
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
50g, rheum officinale 50g, honeysuckle 50g, garden burnet 50g, Chinese gall 50g, borneol 25g, soybean oil 2000g, albolene 1000g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in soybean oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add albolene to be well mixed, be subsequently cooled to 50～60
DEG C, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Embodiment 2
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
50g, rheum officinale 50g, honeysuckle 50g, garden burnet 50g, Chinese gall 50g, borneol 25g, soybean oil 2000g, albolene 600g, beeswax
80g, stearic acid 100g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in soybean oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add albolene to be well mixed, be subsequently cooled to 50～60
DEG C, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Embodiment 3
A kind of Chinese medicinal pigmentum for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
50g, rheum officinale 50g, honeysuckle 50g, garden burnet 50g, Chinese gall 50g, borneol 25g, soybean oil 2000g.
The preparation method of the Chinese medicinal pigmentum of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in soybean oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate cools down 70～80 DEG C, add the powder borneol of 120 mesh using dissolving, obtained
The Chinese medicinal pigmentum for the treatment of hemorrhoid.
Embodiment 4
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
100g, rheum officinale 100g, honeysuckle 100g, garden burnet 50g, Chinese gall 50g, borneol 25g, sesame oil 2000g, Macrogol 4000
200g, Macrogol 6000 800g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in sesame oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add Macrogol 4000, Macrogol 6000 mixing equal
It is even, 50～60 DEG C are subsequently cooled to, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Embodiment 5
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
100g, rheum officinale 100g, honeysuckle 100g, garden burnet 50g, Chinese gall 50g, borneol 25g, sesame oil 2000g, albolene 800g, honeybee
Wax 60g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in sesame oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add albolene, beeswax to be well mixed, be subsequently cooled to
50～60 DEG C, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Embodiment 6
A kind of Chinese medicinal pigmentum for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
100g, rheum officinale 100g, honeysuckle 100g, garden burnet 50g, Chinese gall 50g, borneol 25g, sesame oil 2000g.
The preparation method of the Chinese medicinal pigmentum of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in sesame oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, adding the powder borneol of 120 mesh is well mixed dissolving
To the Chinese medicinal pigmentum for the treatment of hemorrhoid.
Embodiment 7
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
100g, rheum officinale 100g, honeysuckle 100g, garden burnet 100g, Chinese gall 100g, borneol 50g, rapeseed oil 1500g, albolene
500g, beeswax 80g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in rapeseed oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add albolene, beeswax to be well mixed, be subsequently cooled to
50～60 DEG C, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Embodiment 8
A kind of Chinese medicinal ointment for treating hemorrhoid proposed by the present invention, its raw material includes：Golden cypress 100g, coptis 100g, the root of large-flowered skullcap
100g, rheum officinale 100g, honeysuckle 100g, garden burnet 100g, Chinese gall 100g, borneol 50g, sesame oil 2000g, albolene 600g,
Stearic acid 100g.
The preparation method of the Chinese medicinal ointment of above-mentioned treatment hemorrhoid that the present invention is also proposed, by golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale,
Honeysuckle, garden burnet, Chinese gall are crushed, and are added in sesame oil and are soaked 2h, are then heated to 90～100 DEG C, extract 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add stearic acid to be well mixed, be subsequently cooled to 50～60
DEG C, the powder borneol of 120 mesh of addition is well mixed the Chinese medicinal ointment of the hemorrhoid that obtain medical treatment.
Pharmacodynamic study is carried out for the Chinese medicinal ointment of present invention gained treatment hemorrhoid：
I, zoopery：
1st, rat foot claw swelling test：SD rats 60 are taken, body weight 180-200g, male is randomly divided into model group, blank
Control group, positive controls (mayinglong shexiang zhichuang ointments), high dose group of the present invention (concentration is 0.57g crude drugs/g ointment), sheet
Invention middle dose group (0.33g crude drugs/g ointment), low dose group of the present invention (concentration is 0.16g crude drugs/g ointment), 10 per group.
Corresponding medicine, 0.4g ointment/(foot plantar uniform application is defined) are given respectively at every Rat Right foot plantar local；Model group
To distilled water, once a day, successive administration 5 days, administration in the 5th day measures rat foot volume conduct in first 1 hour with glass container method
Rat foot volume before administration, after administration 0.5 hour respectively in each mouse right hind foot plantar subcutaneous injection 1% carrageenan 0.1ml/ only
Inflammation is caused, it is subsequently every to determine once sufficient plantar volume, METHOD FOR CONTINUOUS DETERMINATION 6 times every other hour.Subtract the result that each time period determines after inflammation is caused
The measured value i.e. sufficient pawl swelling degree gone before being administered, its result is as follows：
Impact of the table 1-1 present invention to rat foot claw swelling
Impact of the table 1-2 present invention to rat foot claw swelling
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The paw swelling that the present invention can substantially mitigate rat in 1 hour upon administration, is continued until
6h, and compare with model group, blank control group, with significant difference.
2nd, the ear swelling test of mouse：
60 mouse are taken, body weight 18-22g, male and female half and half are randomly divided into 6 groups：Model group, blank control group, positive control
Group (mayinglong shexiang zhichuang ointments), high dose group of the present invention (concentration is 0.57g crude drugs/g ointment), middle dose group of the present invention
(0.33g crude drugs/g ointment), low dose group of the present invention (concentration is 0.16g crude drugs/g ointment), 10 per group.Apply in mouse right ear
Corresponding each group medicine, 0.2g ointment/only, once a day, continuous 5 days, 30min after last dose, two before and after mouse right ear
Face applies 100% caused by dimethylbenzene xylene inflammation liquid 0.02ml/ only, and left ear does not make any process, and animal is put to death after 4 hours, and ears are cut immediately,
Same area auricle is taken with 8mm card punch, is weighed on assay balance, left auricle weight is deducted as swelling with auris dextra sheet weight
Degree, with (auris dextra weight-left ear weight) ,/left ear weight is as swelling rate, and its result is as follows：
Impact of the present invention of table 2 to mice ear
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention can substantially suppress the ear swelling degree and ear swelling rate of mouse, and with model group, blank
Control group compares, with significant difference.
3rd, hot plate method in mice test：
Hot plate is preheated 10min by the temperature of regulating thermostatic water-bath in (55 ± 0.5) DEG C.18-22g female mices are taken, every time
1 is merely placed on hot plate, and mouse up to occurs licking metapedes required time (s) as the pain threshold of the mouse from hot plate is placed on.It is all lick after
The sufficient time, less than 5s or more than 30s or leaper, gives it up.60 qualified mouse are divided equally at random 6 groups：Model group, sky
White control group, positive controls (mayinglong shexiang zhichuang ointments), high dose group of the present invention (concentration is 0.57g crude drugs/g ointment),
Middle dose group (concentration is 0.33g crude drugs/g ointment) of the present invention, low dose group of the present invention (concentration is 0.16g crude drugs/g ointment),
10 per group.Relative medicines are applied respectively at four sufficient plantars, 0.2g ointment/only, once a day, successive administration 5 days, after last dose
60th, 90,120min determines respectively mouse pain threshold, and such as 60s is still reactionless, and mouse is taken out, in order to avoid scalding, its pain threshold is pressed
60s is calculated, as a result as follows：
The impact that the present invention of table 3 is tested mouse hot-plate
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：1～1.5h upon administration of the invention can significantly improve the pain threshold of mouse, and to mouse pain after 2h
Threshold value changes unobvious.
4th, mouse writhing test：
Take 60 mouse and divide equally 6 groups at random：Model group, blank control group, positive controls (mayinglong shexiang zhichuang ointments),
High dose group of the present invention (concentration is 0.57g crude drugs/g ointment), middle dose group of the present invention (concentration is 0.33g crude drugs/g ointment),
Low dose group (concentration is 0.16g crude drugs/g ointment) of the present invention, 10 per group.Rectally, administered volume 0.2g ointment/only,
Once a day, continuous 5 days, test is started within 1 hour after last dose.Test mice lumbar injection 1mol/L glacial acetic acid 10ml/kg
Writhing is caused, each group mouse writhing number of times in record 15min, its result is as follows：
Impact of the present invention of table 4 to mouse writhing number of times
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：After present invention administration, mouse writhing number of times has certain reduction, with model group, blank control group
Relatively, with significant difference.
5th, mouse docking test：
Mouse 60 is taken, male and female half and half are randomly divided into 6 groups：Model group (distilled water), blank control group, positive controls
(mayinglong shexiang zhichuang ointments), high dose group of the present invention (concentration is 0.57g crude drugs/g ointment), middle dose group (concentration of the present invention
For 0.33g crude drugs/g ointment), low dose group of the present invention (concentration be 0.16g crude drugs/g ointment), 10 per group.Mouse is placed in
Tail 0.5cm is cut in special fixator to clock immediately, corresponding medicine 0.2g ointment/only is smeared after docking immediately, and uses stopwatch
Timing, every 30s filter paper drop of blood is sucked, and to no longer bleeding, records the bleeding time.
Compare with model group and blank control group, the bleeding time of high, medium and low dosage group mouse significantly shortens, difference
There is conspicuousness (P<0.01).Its result is as follows：
Impact of the present invention of table 5 to the mouse docking bleeding time
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：After mouse docking, three groups of bleeding times significantly shorten.
6th, rat Perianal ulceration model test：
60 rats are taken, male and female half and half, all animals first stick anus, filter paper with the filter paper for being soaked with 99% acetum
Piece need to be in close contact anal skin and mucous membrane, and every mouse pastes 1min with 2 filter papers.That afternoon observes ulcer level, by body
60 rats are randomly divided into 6 groups by weight and ulcer level：Model control group (distilled water), blank control group, positive controls (horse
Should imperial Moschus acne cream), high, medium and low dosage group of the invention, crissum smears medicine 0.4g ointment/only, once a day, successive administration
5d, observation the 3rd, 5,7,9 days rat ulcer healing situations of administration, evaluates ulcer level.
Rat Perianal ulceration standards of grading：There is 1 point of ulcer sepage；2 points of a little ulcer sepage；There is eschar to heal substantially 3 points；
Heal 4 points completely.
Its result is as follows：
Impact of the present invention of table 6 to rat Perianal ulceration
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention can obviously reduce rat Perianal ulceration score value, and and model after administration 5 days
Group, blank control group compare, with significant difference.
7th, rat experimental hemorrhoid model test：
Compare with model group and blank control group, the present invention is high, middle dose group 24h after to l% carrageenans starts, can
The swelling of rat crissum is substantially reduced, low dose group 96h after to l% carrageenans can obviously reduce the swollen of rat crissum
Expansibility.
Impact of the present invention of table 7 to rat experimental hemorrhoid
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention upon administration 24h start the swelling that can obviously reduce rat crissum, with model group,
Blank control group compares, with significant difference.
II, human clinical trial：
1st, external piles curative effect is treated：
Choose 166 and make a definite diagnosis external piles patient, maximum 85 years old, minimum 19 years old, the people of pregnant woman 8, the people of women breast-feeding their children 11 are divided into two
Group, in experimental group, other random packets, Jing statistics confirms two groups of ages, diseases for per group of 83 people, wherein pregnant woman, women breast-feeding their children
There was no significant difference for journey.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using present invention gained traditional Chinese medicinal ointment
Agent, once a day；Contrast groups use MAYINGLONGZHICHUANGGAO, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 83 | 66 | 11 | 6 | 0 | 100% |
| Contrast groups | 83 | 56 | 9 | 10 | 8 | 90.4% |
Wherein curative effect determinate standard：
(1) symptom, the sign of fully recovering disappears or basic disappearance, and integrated value reduces more than >=95%, and related physical and chemical index should be just
It is normal or normal.
(2) effective symptom, sign are obviously improved, and integrated value reduces >=70%, and related physical and chemical index is obviously improved.
(3) effectively symptom, sign take a favorable turn, and integrated value reduces >=30%, and related physical and chemical index accordingly takes a turn for the better.
(4) invalid symptom, sign do not improve, and integrated value reduces ＜ 30%, and related physical and chemical index is without improvement.
As seen from the above table：The present invention is better than prior art to the total effective rate of external piles.
2nd, internal piles curative effect is treated：
Choose 144 and make a definite diagnosis internal piles patient, maximum 73 years old, minimum 16 years old, the people of pregnant woman 13, the people of women breast-feeding their children 7 are divided into two
Group, in experimental group, other random packets, Jing statistics confirms two groups of ages, diseases for per group of 72 people, wherein pregnant woman, women breast-feeding their children
There was no significant difference for journey.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using present invention gained traditional Chinese medicinal ointment
Agent, once a day；Contrast groups use MAYINGLONGZHICHUANGGAO, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 72 | 58 | 10 | 4 | 0 | 100% |
| Contrast groups | 72 | 54 | 7 | 6 | 5 | 93.1% |
As seen from the above table：The present invention is better than prior art to the total effective rate of internal piles.
3rd, mixed hemorrhoid curative effect is treated：
Choose 114 and make a definite diagnosis mixed hemorrhoid patient, maximum 69 years old, minimum 18 years old, the people of pregnant woman 6, the people of women breast-feeding their children 6 are divided into
Two groups, per group of 57 people, wherein pregnant woman, women breast-feeding their children in experimental group, other random packets, Jing statistics confirm two groups of ages,
There was no significant difference for sex, the course of disease.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using present invention gained
Chinese medicinal ointment, once a day；Contrast groups use MAYINGLONGZHICHUANGGAO, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 57 | 42 | 9 | 6 | 0 | 100% |
| Contrast groups | 57 | 38 | 7 | 5 | 7 | 87.7% |
As seen from the above table：The present invention is better than prior art to the total effective rate of mixed hemorrhoid.
4th, postoperation treatment curative effect：
Choose 102 and make a definite diagnosis postoperation patient, maximum 64 years old, minimum 17 years old, the people of pregnant woman 3, the people of women breast-feeding their children 7,
Random packet, in experimental group, other random packets, Jing statistics confirms two groups of years for per group of 51 people, wherein pregnant woman, women breast-feeding their children
There was no significant difference for age, the course of disease.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using in present invention gained
Ointment agent, once a day；Contrast groups use MAYINGLONGZHICHUANGGAO, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 51 | 39 | 8 | 4 | 0 | 100% |
| Contrast groups | 51 | 35 | 5 | 4 | 7 | 86.3% |
As seen from the above table：The present invention is better than prior art to the total effective rate of postoperation.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept equivalent or change in addition, all should be included within the scope of the present invention.
Claims (7)
1. a kind of Chinese medicinal ointment for treating hemorrhoid, it is characterised in that its raw material includes：Chinese medicine composition, vegetable oil and matrix.Its
Middle Chinese medicine composition includes by weight：0.6～2.0 part of golden cypress, 0.6～2.0 part of the coptis, 0.6～2.0 part of the root of large-flowered skullcap, rheum officinale 0.6
～2.0 parts, 0.6～2.0 part of honeysuckle, 0.6～2.0 part of garden burnet, 0.6～2.0 part of Chinese gall, 0.3～1.0 part of borneol.
2. the Chinese medicinal ointment of hemorrhoid is treated according to claim 1, it is characterised in that vegetable oil is soybean oil, rapeseed oil, fiber crops
One or more compositions in oil.
3. according to any one of claim 1 or 2 treat hemorrhoid Chinese medicinal ointment, it is characterised in that matrix be albolene,
In beeswax, stearic acid, lanolin, hydrogenated vegetable oil, dimeticone, glycerine, gelatin, Macrogol 4000, Macrogol 6000
One or more compositions.
4. the Chinese medicinal ointment of hemorrhoid is treated according to any one of claim 1-3, it is characterised in that Chinese medicine composition and plant
The weight ratio of oil is 1:2～6.
5. the Chinese medicinal ointment of hemorrhoid is treated according to any one of claim 1-4, it is characterised in that the weight of matrix and vegetable oil
Amount is than being 1:1～3.
6. the Chinese medicinal ointment of hemorrhoid is treated according to any one of claim 1-5, it is characterised in that Chinese medicine composition is by weight
Part includes：1.0 parts of golden cypress, 1.0 parts of the coptis, 1.0 parts of the root of large-flowered skullcap, 1.0 parts of rheum officinale, 1.0 parts of honeysuckle, 1.0 parts of garden burnet, Chinese gall
1.0 parts, 0.5 part of borneol.
7. it is a kind of as described in any one of claim 1-6 treat hemorrhoid Chinese medicinal ointment preparation method, it is characterised in that include
Following steps：Golden cypress, the coptis, the root of large-flowered skullcap, rheum officinale, honeysuckle, garden burnet, Chinese gall are crushed, are added and soak in vegetable oil 1～3h,
It is then heated to 80～110 DEG C, extracts 1～3h, then be warming up to 120～150 DEG C, extract 0.2～1h, filter, filtrate is cooled to
70 DEG C～100 DEG C, add matrix to be well mixed, be subsequently cooled to 40～80 DEG C, the borneol of addition powder is well mixed and obtains
The Chinese medicinal ointment for the treatment of hemorrhoid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611030882.1A CN106581246A (en) | 2016-11-17 | 2016-11-17 | Traditional Chinese medicine paste for treating hemorrhoids and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611030882.1A CN106581246A (en) | 2016-11-17 | 2016-11-17 | Traditional Chinese medicine paste for treating hemorrhoids and preparation method thereof |
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ID=58592543
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108014183A (en) * | 2017-12-22 | 2018-05-11 | 廖俞森 | A kind of medicine for treating burns, scald, trauma |
| CN112516275A (en) * | 2019-09-18 | 2021-03-19 | 谢文淦 | Preparation method of Yishengtang dermatitis ointment |
| CN112587576A (en) * | 2020-11-25 | 2021-04-02 | 浙江中医药大学 | Traditional Chinese medicine composition for treating haemorrhoids and preparation method and application thereof |
-
2016
- 2016-11-17 CN CN201611030882.1A patent/CN106581246A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108014183A (en) * | 2017-12-22 | 2018-05-11 | 廖俞森 | A kind of medicine for treating burns, scald, trauma |
| CN112516275A (en) * | 2019-09-18 | 2021-03-19 | 谢文淦 | Preparation method of Yishengtang dermatitis ointment |
| CN112587576A (en) * | 2020-11-25 | 2021-04-02 | 浙江中医药大学 | Traditional Chinese medicine composition for treating haemorrhoids and preparation method and application thereof |
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