CN106491788A - A kind of treat Chinese medicine gel of hemorrhoid and preparation method thereof - Google Patents
A kind of treat Chinese medicine gel of hemorrhoid and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention discloses a kind of Chinese medicine gel for treating hemorrhoid, its raw material includes：Chinese medicine composition, vegetable oil and substrate, Chinese medicine composition include by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, 0.6～2.0 part of Radix Et Rhizoma Rhei, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.Vegetable oil is Oleum Brassicae campestriss, soybean oil and/or Oleum Sesami；Substrate is Cera Flava, Pluronic F-127, lanoline, gelatin and/or Polyethylene Glycol.The invention also discloses the Chinese medicine gel preparation method of above-mentioned treatment hemorrhoid.Gained Chinese medicine gel of the present invention adopts parts of generic medicinal plants, and low price, infection are strong, and alleviating pain and detumescence speed is fast, and good effect has no toxic side effect, it is adaptable to the treatment of external hemorrhoid, internal hemorrhoid, mixed hemorrhoid and postoperation.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of treat Chinese medicine gel of hemorrhoid and preparation method thereof.
Background technology
The traditional Chinese medical science very early, can trace back to business's epoch summer according to literature record to the Cognitive Origin of " hemorrhoid ".Hemorrhoid are a kind of normal
See that disease, frequently-occurring disease, all ages and classes can all occur with different sexes crowd, therefore often have saying for " ten people, nine hemorrhoid ".《Danxi's experiential therapy》Cloud：
" hemorrhoid person all because of internal organs deficiency in origin, wound rheumatism, interior intrinsic heat poison, so that falling under QI and blood, ties poly- anus, and dyspepsia does not dissipate, and it is hemorrhoid to conflict
",《Yizong Jinjian》Also cloud：" hemorrhoid form and name also many as, the scorching source of not outer rheumatism ", it is indicated that internal organs weakness is the pathogenetic base of hemorrhoid
This factor, it is the pathogenetic major reason of hemorrhoid to experience rheumatism pathogenic dryness-heat.The traditional Chinese medical science thinks, with regard to the origin cause of formation of hemorrhoid, how by sitting, long
Stand, chronic diarrhea, secret long, chronic cough, or do one's utmost bear a heavy burden, gestation fertility etc. cause QI and blood in length and breadth, foul smell blood stasis, multiple abscess anus, lump formation due to accumulation of pathogens
Into hemorrhoid.Eating and drinking without temperance, surfeit are pungent, production of dryness-heat in the interior, and gas is compeled blood stasis and swollen and ache.Doctor trained in Western medicine thinks, earns, firmly lift during defecation under exerting oneself
Weight or cough, cause anus edge angiorrhexiss, and in subcutaneous formation enclosed mass, the superfluous skin hypertrophy of anus edge forms external hemorrhoid to accumulation of blood.Feces
Retention, stimulates local to cause inflammation, outside internal hemorrhoid abjection anus, is clamped by sphincter, and venous return is obstructed, but arterial blood is still constantly defeated
Enter, the internal hemorrhoid hyperemia of abjection, volume is constantly increased, until the arterial blood of input is pressed to cause blood stasis to be formed.Primary disease common go out
The three big symptom such as blood, pain, constipation, easily patient suffering and recurrence.
The traditional Chinese medical science to the method for the treatment of of hemorrhoid based on external treatment, its unique non-operative treatment compared with doctor trained in Western medicine operative therapy have bright
Aobvious advantage.Operative therapy technical requirements and costly, and Post operation easily occur pain, bleeding, infection, wound healing slow,
The complication such as anus edge edema；And traditional Chinese medical science non-operative treatment can then avoid similar complication from occurring, the method is simple to operate in addition, again may be used
Mitigate patient's pain, be particularly well-suited to the patient of age, body void.Traditional Chinese medical science non-operative treatment be also at present treatment operative therapy concurrent
The best approach of disease.Certainly, there is dosage inequality in Traditional Chinese Medicine non-operative treatment such as fumigation and wash method method, method of topical application, turunda method etc.
Weighing apparatus, Different therapeutical effect are big, the defect such as patient medication inconvenience, poor compliance.Therefore, exploitation facilitate patient using Chinese medicine control hemorrhoid system
Agent is the inevitable choice combined with modern Chinese medicine preparation technique by the traditional non-operative treatment of the traditional Chinese medical science.
Using the Chinese crude drug of famous and precious or resource scarcity the prescriptions of Chinese medicine of existing treatment hemorrhoid, such as more：Moschus, Lignum Aquilariae Resinatum, Fel Ursi,
Sanguis Draxonis, Squama Maniss etc..At present, contain in MAYINGLONG MUSK HEMORRHOID UNGUENTUM, bear's gall ointment and the anus Thailand sold on domestic market
Fel Ursi used by Moschus, Fel Ursi hemorrhoid spirit cream prescription, and JINGWANHONG ZHICHUANG GAO prescription uses Sanguis Draxonis and Squama Maniss；Patents are such as
CN1546084A, CN102697836A, CN103071008A etc. also imitate similar prescription one after another.In addition, using drug effect to improve
Really, convergence putrefaction removing effect, or even the toxic herb material, such as CN1679722A such as Calomelass used in prescription, Hydrargyri Oxydum Rubrum, Vermilion are strengthened.
To sum up, famous and precious or resource scarcity Chinese crude drug consumed in a large number, and can introduce that medical supply is unbalance and its quality is unstable at any time etc. can not
Control factor, causes stern challenge to drug quality and price, and the use of the toxic traditional Chinese medicine material such as Calomelass, Hydrargyri Oxydum Rubrum, Vermilion is even more
Allow patient to hang back, and the use of the strong medical material of blood-activating and qi-promoting power such as Moschus, Sanguis Draxonis, Squama Maniss is not suitable for age of sucking and pregnant yet
Phase patient, has further limited to promotion and application of the Chinese medicine in terms of hemorrhoid are controlled.
Content of the invention
Based on background technology exist limitation and deficiency, the invention provides a kind of Chinese medicine gel for treating hemorrhoid and its
Preparation method.The Chinese medicine gel prescription of the present invention adopts conventional, nontoxic, inexpensive Chinese crude drug, the prescription have infection by force,
Alleviating pain and detumescence is fast, quick-acting safe the characteristics of.It is applied to the treatment of external hemorrhoid, internal hemorrhoid, mixed hemorrhoid and hemorrhoid operation infectious-related complication, more
Specifically it is applied to age of sucking and pregnant patients.
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Chinese medicine composition, vegetable oil and base
Matter, Chinese medicine composition include by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, Radix Et Rhizoma Rhei
0.6～2.0 part, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.
Preferably, vegetable oil be soybean oil, Oleum Brassicae campestriss, one or more compositionss in Oleum Sesami.
Preferably, substrate be Cera Flava, polyethylene glycol oxide, lanoline, gelatin, Macrogol 4000, in polyethylene glycol 6000
One or more compositionss.
Preferably, the weight ratio of Chinese medicine composition and vegetable oil is 1:2～6.
Preferably, the weight ratio of substrate and vegetable oil is 1:1～3.
Preferably, Chinese medicine composition includes by weight：1.0 parts of Cortex Phellodendri, 1.0 parts of Rhizoma Coptidis, 1.0 parts of Radix Scutellariae, Radix Et Rhizoma Rhei 1.0
Part, 1.0 parts of Flos Lonicerae, 1.0 parts of Radix Sanguisorbae, 1.0 parts of Galla Chinensiss, 0.5 part of Borneolum Syntheticum.
The preparation method of the Chinese medicine gel of the above-mentioned treatment hemorrhoid that the present invention is also proposed, comprises the steps：By Cortex Phellodendri,
Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in vegetable oil and are soaked 1～3h, are then heated to 80～110
DEG C, 1～3h to be extracted, then is warming up to 120～150 DEG C, extract 0.2～1h, filtered, filtrate is cooled to 70 DEG C～100 DEG C, adds base
Matter mix homogeneously, is subsequently cooled to 40～80 DEG C, adds the Borneolum Syntheticum mix homogeneously of powder to obtain medical treatment the Traditional Chinese medicine gel of hemorrhoid
Agent.
The present invention adopts Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, eight taste medicinal material composition of Galla Chinensiss and Borneolum Syntheticum,
There is clearing away heat and loosing the bowels, hemostasis, reducing swelling and alleviating pain.Wherein Cortex Phellodendri bitter in the mouth, cold in nature；There is heat clearing and damp drying, eliminating fire and detoxication, removing toxic substances
Treat effect of skin ulcer.Rhizoma Coptidis bitter in the mouth, cold in nature；There is clearing away heat-fire, dampness, removing toxic substances.Radix Scutellariae bitter in the mouth, cold in nature；There is heat clearing away
Pathogenic fire purging, dampness removing toxic substances, hemostasis, antiabortive effect, have antibacterial, antiinflammatory, antioxidation, resistance state concurrently and strengthen immunocompetence effect.
Radix Et Rhizoma Rhei bitter in the mouth, cold in nature；Have and attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, removing toxic substances.Radix Sanguisorbae bitter in the mouth, acid, puckery, cold nature；Tool
There are cooling blood for hemostasis, removing toxic substances sore, have hemostasis, antibacterial, antiviral and antiinflammatory action concurrently.Galla Chinensiss sour in the mouth, puckery, cold in nature；
There is astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore.Flos Lonicerae sweet in the mouth, cold in nature；There is heat-clearing and toxic substances removing,
Effect of dispelling wind and heat pathogens.Borneolum Syntheticum acrid in the mouth, hardship, are slightly cold；There is inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain.
Based on Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, this four medicine is shared the medicinal material composition of the present invention, heat-clearing and toxic substances removing, pathogenic fire purging
The power of dampness is strong, assaults the main target " rheumatism pathogenic dryness-heat ", and eliminating evil is consolidated.In addition, being aided with Galla Chinensiss, Radix Sanguisorbae strengthens convergence, anastalsis,
Strengthen radiating analgesic efficacy with Flos Lonicerae, Borneolum Syntheticum again, this four medicine shares and is to take stopgap measures, for alleviating hemorrhoid symptom, mitigate patient
Pain.
Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Galla Chinensiss, Radix Sanguisorbae and Flos Lonicerae used by of the invention is domestic ecosystem road real estate
Medical material or the prepared slices of Chinese crude drugs, quality meet current edition Chinese Pharmacopoeia requirement.
The Chinese medicine gel of the present invention is studied through hospital clinical, and in July, 2014, in June, 2016, adds up treatment hemorrhoid and suffers from
186 people of person, male 106 people, 80 people of woman, age are minimum 21 years old, and maximum 68 years old, the course of disease is most short 2 weeks, most long 11 years, wherein external hemorrhoid
43 people (2 people of anemia of pregnant woman, 6 people of women breast-feeding their children), 68 people of internal hemorrhoid (6 people of anemia of pregnant woman, 9 people of women breast-feeding their children), (anemia of pregnant woman 3 for 47 people of mixed hemorrhoid
People, 9 people of women breast-feeding their children), 28 people of post-operative complication (3 people of anemia of pregnant woman, 7 people of women breast-feeding their children), medication 1～3 week cure 143,
Effective 23, effective 20, invalid 0, during medication, there is no untoward reaction, patient's compliance is good.Present invention treatment
Effective percentage 100%.
Relative to prior art, the present invention has advantages below：
1st, medical material of the present invention is conventional cheap medical material or the prepared slices of Chinese crude drugs, and ample supply of commodities on the market, quality are guaranteed；
2nd, Chinese medicine gel therapeutic domain of the invention is wide, it is adaptable to all kinds hemorrhoid such as external hemorrhoid, internal hemorrhoid, mixed hemorrhoid
Treatment, is more suitable for the treatment of hemorrhoid operation infectious-related complication；
3rd, Chinese medicine gel safe without toxic side effect of the invention, good patient compliance are suitable for crowd extensively, are particularly suited for
Age of sucking and pregnant patients；
4th, Chinese medicine gel of the invention is rapid-action, and pain relieving, hemostasis, detumescence effect are good, and medication can be stopped blooding for 3 minutes, and 15
Minute eliminates pain, and 60 minutes start to subside a swelling, and a drug can maintain curative effect 6h, medication lump to be completely eliminated in 1～3 week,
Treatment cycle is short, and treated effect is high.
Specific embodiment
Below, technical scheme is described in detail by specific embodiment.
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 50g, Radix Et Rhizoma Rhei 50g, Flos Lonicerae 50g, Radix Sanguisorbae 50g, Galla Chinensiss 50g, Borneolum Syntheticum 25g, soybean oil 2000g, polyethylene glycol oxide
1000g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in soybean oil and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are risen
Temperature extracts 0.5h to 135～145 DEG C, filters, and filtrate is cooled to 80 DEG C, adds polyethylene glycol oxide mix homogeneously, is subsequently cooled to
50～60 DEG C, the powder Borneolum Syntheticum mix homogeneously of 120 mesh is added to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 2
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 50g, Radix Et Rhizoma Rhei 50g, Flos Lonicerae 50g, Radix Sanguisorbae 50g, Galla Chinensiss 50g, Borneolum Syntheticum 25g, soybean oil 2000g, polyethylene glycol oxide 800g,
Lanoline 400g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in soybean oil and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are risen
Temperature extracts 0.5h to 135～145 DEG C, filters, and filtrate is cooled to 80 DEG C, adds polyethylene glycol oxide, lanoline mix homogeneously, so
After be cooled to 50～60 DEG C, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 3
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 50g, Galla Chinensiss 50g, Borneolum Syntheticum 25g, Oleum Sesami 2000g, lanoline 1000g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in Oleum Sesami and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are heated up
To 135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, added lanoline mix homogeneously, be subsequently cooled to 50～60
DEG C, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 4
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 50g, Galla Chinensiss 50g, Borneolum Syntheticum 25g, Oleum Sesami 2000g, lanoline 800g, honeybee
Wax 80g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in Oleum Sesami and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are heated up
To 135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, added lanoline, Cera Flava mix homogeneously, be subsequently cooled to
50～60 DEG C, the powder Borneolum Syntheticum mix homogeneously of 120 mesh is added to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 5
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Brassicae campestriss 1800g, lanoline
600g, Cera Flava 40g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in Oleum Brassicae campestriss and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are risen
Temperature extracts 0.5h to 135～145 DEG C, filters, and filtrate is cooled to 80 DEG C, adds lanoline, Cera Flava mix homogeneously, then cools down
To 50～60 DEG C, the powder Borneolum Syntheticum mix homogeneously of 120 mesh is added to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 6
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Sesami 2000g, gelatin 400g, poly-
6000 600g of ethylene glycol.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in Oleum Sesami and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are heated up
To 135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add gelatin, polyethylene glycol 6000 mix homogeneously, then
50～60 DEG C are cooled to, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh to obtain medical treatment the Chinese medicine gel of hemorrhoid.
Embodiment 7
A kind of Chinese medicine gel for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Huang
A kind of reed mentioned in ancient books 100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Sesami 2000g, lanoline 600g,
Macrogol 4000 200g, Polyethylene oxide 200g.
The preparation method of the Chinese medicine gel of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, big
Huang, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and are added in Oleum Sesami and are soaked 2h, are then heated to 90～100 DEG C, are extracted 2h, then are heated up
To 135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add lanoline, Macrogol 4000, Polyethylene oxide to mix
Close uniform, be subsequently cooled to 50～60 DEG C, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh to obtain medical treatment the Traditional Chinese medicine gel of hemorrhoid
Agent.
The Chinese medicine gel that hemorrhoid are treated for gained of the present invention carries out pharmacodynamic study：
I, zoopery：
1st, rat foot claw swelling test：SD rats 60 are taken, body weight 180-200g, male are randomly divided into model group, blank
Matched group, positive controls (MAYINGLONG MUSK HEMORRHOID UNGUENTUM), high dose group of the present invention (concentration is 0.60g crude drugs/g gels), sheet
Invention middle dose group (0.40g crude drugs/g gels), low dose group of the present invention (concentration is 0.20g crude drugs/g gels), 10 per group.
Corresponding medicine, 0.4g gels/(foot plantar uniform application is defined) are given respectively at every Rat Right foot plantar local；Model group
Distilled water is given, once a day, successive administration 5 days, administration in the 5th day measure rat foot volume conduct with glass container method in first 1 hour
Rat foot volume before administration, after administration 0.5 hour respectively in each Mus right hind foot plantar subcutaneous injection 1% carrageenin 0.1ml/ only
Cause scorching, subsequently per determining once sufficient plantar volume, METHOD FOR CONTINUOUS DETERMINATION 6 times every other hour.Subtract the result that each time period determines after inflammation is caused
The measured value i.e. sufficient pawl swelling degree gone before being administered, its result are as follows：
Table 1-1 impacts of the present invention to rat foot claw swelling (N=10)
Table 1-2 impacts of the present invention to rat foot claw swelling (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The paw swelling that the present invention can substantially mitigate rat in 1 hour upon administration, is continued until
6h, and compare with model group, blank control group, with significant difference.
2nd, the ear swelling test of mice：
60 mices are taken, body weight 18-22g, male and female half and half are randomly divided into 6 groups：Model group, blank control group (substrate), sun
Property matched group (MAYINGLONG MUSK HEMORRHOID UNGUENTUM), high dose group of the present invention (concentration be 0.60g crude drugs/g gels), middle dosage of the present invention
Group (0.40g crude drugs/g gels), low dose group of the present invention (concentration is 0.20g crude drugs/g gels), 10 per group.In mouse right ear
Apply corresponding each group medicine, 0.2g gels/only, once a day, continuous 5 days, 30min after last dose, before and after mouse right ear
Two sides only applies 100% caused by dimethylbenzene xylene inflammation liquid 0.02ml/, and left ear does not make any process, puts to death animal after 4 hours, cuts immediately double
Ear, takes same area auricle with 8mm card punch, weighs on analytical balance, and it is swollen to deduct left auricle weight with auris dextra sheet weight
Expansibility, with (auris dextra weight-left ear weight), as swelling rate, its result is as follows for/left ear weight：
Impact of 2 present invention of table to mice ear (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention can substantially suppress ear swelling degree and the ear swelling rate of mice, and with model group, blank
Matched group compares, with significant difference.
3rd, hot plate method in mice test：
Hot plate is preheated 10min in (55 ± 0.5) DEG C by the temperature of regulating thermostatic water-bath.18-22g female mices are taken, every time
1 is merely placed on hot plate, and mice is placed on the pain threshold of (s) as the Mus the time required to hot plate up to occurs licking metapedes certainly.All lick after
The sufficient time, less than 5s or more than 30s or leaper, gives it up.60 qualified mices are divided equally 6 groups at random：Model group, sky
(concentration is 0.60g crude drugs/g for white matched group (substrate), positive controls (MAYINGLONG MUSK HEMORRHOID UNGUENTUM), high dose group of the present invention
Gel), middle dose group of the present invention (concentration be 0.40g crude drugs/g gels), (concentration is 0.20g crude drugs/g to low dose group of the present invention
Gel), 10 per group.Relative medicines are applied respectively at four sufficient plantars, 0.2g gels/only, once a day, successive administration 5 days, last
60 after administration, 90,120min determine mice pain threshold respectively, such as 60s is still reactionless, and mice is taken out, so as not to scald, its threshold of pain
Value presses 60s calculating, as a result as follows：
Impact that 3 present invention of table is tested to mouse hot-plate (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：1～1.5h upon administration of the invention can significantly improve the pain threshold of mice, and to mice pain after 2h
Threshold value changes unobvious.
4th, mouse writhing test：
Take 60 mices and divide equally 6 groups at random：Model group, blank control group (substrate), positive controls (Ma Yinglong Moschus hemorrhoid
Skin ulcer cream), high dose group of the present invention (concentration be 0.60g crude drugs/g gels), (concentration is 0.40g crude drugs/g to middle dose group of the present invention
Gel), low dose group of the present invention (concentration be 0.20g crude drugs/g gels), 10 per group.Rectally, administered volume 0.2g coagulate
Glue/only, once a day, continuous 5 days, 1 hour after last dose started to test.Test mice lumbar injection 1mol/L glacial acetic acid
10ml/kg causes writhing, and each group mouse writhing number of times in record 15min, its result are as follows：
Impact of 4 present invention of table to mouse writhing number of times (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：After present invention administration, mouse writhing number of times has certain minimizing, with model group, blank control group
Relatively, with significant difference.
5th, mice docking test：
Mice 60 is taken, male and female half and half are randomly divided into 6 groups：Model group (distilled water), blank control group (substrate), the positive
Matched group (MAYINGLONG MUSK HEMORRHOID UNGUENTUM), high dose group of the present invention (concentration is 0.60g crude drugs/g gels), middle dose group of the present invention
(concentration is 0.40g crude drugs/g gels), low dose group of the present invention (concentration is 0.20g crude drugs/g gels), 10 per group.By mice
It is placed in special holder and cuts tail 0.5cm and clock immediately, smears corresponding medicine 0.2g gels/only after docking immediately, be used in combination
Manual time-keeping, sucks drop of blood every 30S filter paper, to no longer bleeding, records the bleeding time.
Compare with model group and blank control group, the bleeding time of high, medium and low dosage group mice significantly shortens, difference
There is significance (P<0.01).Its result is as follows：
5 present invention of table to mice dock the bleeding time impact (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：After mice docking, three groups of bleeding times significantly shorten.
6th, rat Perianal ulceration model test：
60 rats are taken, male and female half and half, all animals first stick anus, filter paper with the filter paper for being soaked with 99% acetum
Piece need to be in close contact anal skin and mucosa, and every Mus paste 1min with 2 filter papers.That afternoon observes ulcer level, by body
60 rats are randomly divided into 6 groups by weight and ulcer level：Model control group (distilled water), blank control group (substrate), the positive are right
According to group (MAYINGLONG MUSK HEMORRHOID UNGUENTUM), high, medium and low dosage group of the invention, crissum smears medicine 0.4g gels/only, once a day,
Successive administration 5d, observation the 3rd, 5,7,9 days rat ulcer healing situations of administration, evaluates ulcer level.
Rat Perianal ulceration standards of grading：There is 1 point of ulcer sepage；2 points of a little ulcer sepage；There is eschar to heal substantially 3 points；
Heal 4 points completely.
Its result is as follows：
Impact of 6 present invention of table to rat Perianal ulceration (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention can obviously reduce rat Perianal ulceration score value, and and model after administration 5 days
Group, blank control group compare, with significant difference.
7th, rat experimental hemorrhoid model test：
Compare with model group and blank control group, the present invention is high, middle dose group 24h after to l% carrageenin starts, can
Substantially reduce the swelling of rat crissum, low dose group 96h after to l% carrageenin can obviously reduce the swollen of rat crissum
Expansibility.
Impact of 7 present invention of table to rat experimental hemorrhoid (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,△P<0.05,△△P<0.01
As seen from the above table：The present invention upon administration 24h start the swelling that can obviously reduce rat crissum, with model group,
Blank control group compares, with significant difference.
II, human clinical trial：
1st, external hemorrhoid curative effect is treated：
Choose 86 and make a definite diagnosis external hemorrhoid patient, maximum 62 years old, minimum 23 years old, 2 people of anemia of pregnant woman, 6 people of women breast-feeding their children are divided into two
Group, in experimental group, other are grouped at random for per group of 43 people, wherein anemia of pregnant woman, women breast-feeding their children, confirm two groups of ages, diseases through statistics
There was no significant difference for journey.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using gained Traditional Chinese medicine gel of the present invention
Agent, once a day；Matched group uses MAYINGLONGZHICHUANGGAO, once a day.As a result as follows：
| n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate | |
| Experimental group | 43 | 33 | 4 | 6 | 0 | 100% |
| Matched group | 43 | 26 | 5 | 5 | 6 | 83.7% |
Wherein curative effect determinate standard：
(1) recovery from illness symptom, sign disappear or basic disappearance, and integrated value reduces more than >=95%, and related physical and chemical index should be just
Normal or normal.
(2) effective symptom, sign are obviously improved, and integrated value reduces >=70%, and related physical and chemical index is obviously improved.
(3) effectively symptom, sign take a favorable turn, and integrated value reduces >=30%, and related physical and chemical index accordingly takes a turn for the better.
(4) invalid symptom, sign do not improve, and integrated value reduces ＜ 30%, and related physical and chemical index is without improvement.
As seen from the above table：The present invention is better than prior art to the total effective rate of external hemorrhoid.
2nd, internal hemorrhoid curative effect is treated：
Choose 136 and make a definite diagnosis internal hemorrhoid patient, maximum 64 years old, minimum 25 years old, 6 people of anemia of pregnant woman, 9 people of women breast-feeding their children are divided into two
Group, in experimental group, other are grouped at random for per group of 68 people, wherein anemia of pregnant woman, women breast-feeding their children, confirm two groups of ages, diseases through statistics
There was no significant difference for journey.Two groups of diet, daily life systems are consistent, and wherein experimental group is daily using gained Traditional Chinese medicine gel of the present invention
Agent, once a day；Matched group uses MAYINGLONGZHICHUANGGAO, once a day.As a result as follows：
| n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate | |
| Experimental group | 68 | 52 | 9 | 7 | 0 | 100% |
| Matched group | 68 | 43 | 6 | 6 | 13 | 80.9% |
As seen from the above table：The present invention is better than prior art to the total effective rate of internal hemorrhoid.
3rd, mixed hemorrhoid curative effect is treated：
Choose 94 and make a definite diagnosis mixed hemorrhoid patient, maximum 68 years old, minimum 27 years old, 3 people of anemia of pregnant woman, 9 people of women breast-feeding their children are divided into two
Group, in experimental group, other are grouped at random for per group of 47 people, wherein anemia of pregnant woman, women breast-feeding their children, confirm two groups of ages, property through statistics
, there was no significant difference for the course of disease, and two groups of diet, daily life systems are consistent, wherein experimental group daily using gained of the present invention in
Ointment agent, once a day；Matched group uses MAYINGLONGZHICHUANGGAO, once a day.As a result as follows：
| n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate | |
| Experimental group | 47 | 39 | 5 | 3 | 0 | 100% |
| Matched group | 47 | 28 | 6 | 7 | 6 | 87.2% |
As seen from the above table：The present invention is better than prior art to the total effective rate of mixed hemorrhoid.
4th, postoperation treatment curative effect：
Choose 56 and make a definite diagnosis postoperation patient, maximum 62 years old, minimum 21 years old, 3 people of anemia of pregnant woman, 9 people of women breast-feeding their children, point
Into two groups, in experimental group, other are grouped at random for per group of 28 people, wherein anemia of pregnant woman, women breast-feeding their children, confirm two groups of years through statistics
There was no significant difference for age, sex, the course of disease, wherein experimental group daily using gained Chinese medicine gel of the present invention, once a day；Control
Group uses MAYINGLONGZHICHUANGGAO, once a day.As a result as follows：
| n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate | |
| Experimental group | 28 | 19 | 5 | 4 | 0 | 100% |
| Matched group | 28 | 13 | 4 | 4 | 7 | 75.0% |
As seen from the above table：The present invention is better than prior art to the total effective rate of postoperation.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept equivalent or change in addition, should all be included within the scope of the present invention.
Claims (7)
1. a kind of Chinese medicine gel for treating hemorrhoid, it is characterised in that its raw material includes：Chinese medicine composition, vegetable oil and substrate,
Wherein Chinese medicine composition includes by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, Radix Et Rhizoma Rhei
0.6～2.0 part, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.
2. according to claim 1 treat hemorrhoid Chinese medicine gel, it is characterised in that vegetable oil be soybean oil, Oleum Brassicae campestriss,
One or more compositionss in Oleum Sesami.
3. the Chinese medicine gel of hemorrhoid is treated according to any one of claim 1-2, it is characterised in that substrate is Cera Flava, gathers
One or more compositionss in oxygen ethylene, lanoline, gelatin, Macrogol 4000, polyethylene glycol 6000.
4. the Chinese medicine gel of hemorrhoid is treated according to any one of claim 1-3, it is characterised in that Chinese medicine composition and plant
The weight ratio of thing oil is 1:2～6.
5. the Chinese medicine gel of hemorrhoid is treated according to any one of claim 1-4, it is characterised in that substrate and vegetable oil
Weight ratio is 1:1～3.
6. the Chinese medicine gel of hemorrhoid is treated according to any one of claim 1-5, it is characterised in that Chinese medicine composition is by weight
Amount part includes：1.0 parts of Cortex Phellodendri, 1.0 parts of Rhizoma Coptidis, 1.0 parts of Radix Scutellariae, 1.0 parts of Radix Et Rhizoma Rhei, 1.0 parts of Flos Lonicerae, 1.0 parts of Radix Sanguisorbae, Galla Chinensiss
1.0 parts, 0.5 part of Borneolum Syntheticum.
7. a kind of as described in any one of claim 1-6 treat hemorrhoid Chinese medicine gel preparation method, it is characterised in that bag
Include following steps：By Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss crush, add vegetable oil in immersion 1～
3h, is then heated to 80～110 DEG C, extracts 1～3h, then is warming up to 120～150 DEG C, extracts 0.2～1h, filters, and filtrate cools down
To 70 DEG C～100 DEG C, substrate mix homogeneously is added, 40～80 DEG C are subsequently cooled to, add the Borneolum Syntheticum mix homogeneously of powder to obtain
Chinese medicine gel to treatment hemorrhoid.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721461A (en) * | 2017-04-21 | 2018-11-02 | 上海市金山区中西医结合医院 | It is a kind of to hold back the scattered preparation method of hemorrhoid |
| CN114869812A (en) * | 2021-04-19 | 2022-08-09 | 苏州宝丽洁日化有限公司 | Antibacterial composition and wet toilet paper containing same |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721461A (en) * | 2017-04-21 | 2018-11-02 | 上海市金山区中西医结合医院 | It is a kind of to hold back the scattered preparation method of hemorrhoid |
| CN114869812A (en) * | 2021-04-19 | 2022-08-09 | 苏州宝丽洁日化有限公司 | Antibacterial composition and wet toilet paper containing same |
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Application publication date: 20170315 |