CN106552065A - It is a kind of to treat Chinese medicine suppository of hemorrhoid and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine suppository of hemorrhoid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine suppository for treating hemorrhoid, its composition includes：Chinese medicine composition, vegetable oil and substrate, wherein Chinese medicine composition include by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, 0.6～2.0 part of Radix Et Rhizoma Rhei, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.Vegetable oil is Oleum Brassicae campestriss, soybean oil and/or Oleum Sesami；Substrate is cocoa butter, semi-synthetic fatty acid ester and/or mixed fatty glycerides.The invention also discloses the Chinese medicine suppository preparation method of above-mentioned treatment hemorrhoid.Gained Chinese medicine suppository of the invention adopts parts of generic medicinal plants, and low price, infection are strong, and alleviating pain and detumescence speed is fast, and good effect has no toxic side effect, it is adaptable to internal hemorrhoid and the postoperative treatment of internal hemorrhoid.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of treat Chinese medicine suppository of hemorrhoid and preparation method thereof.
Background technology
The traditional Chinese medical science very early, can trace back to business's epoch summer according to literature record to the Cognitive Origin of " hemorrhoid ".Hemorrhoid are a kind of normal
See disease, frequently-occurring disease, all ages and classes can all occur with different sexes crowd, therefore often have saying for " ten people, nine hemorrhoid ".《Danxi's experiential therapy》Cloud：
" hemorrhoid person all because of internal organs deficiency in origin, wound rheumatism, interior intrinsic heat poison, so that falling under QI and blood, ties poly- anus, and dyspepsia does not dissipate, and conflicts for hemorrhoid
",《Yizong Jinjian》Also cloud：" hemorrhoid form and name also many as, the scorching source of not outer rheumatism ", it is indicated that internal organs weakness is the pathogenetic base of hemorrhoid
This factor, it is the pathogenetic major reason of hemorrhoid to experience rheumatism pathogenic dryness-heat.The traditional Chinese medical science thinks, with regard to the origin cause of formation of hemorrhoid, more by sitting, long
Stand, chronic diarrhea, long secret, chronic cough, or do one's utmost to bear a heavy burden, gestation fertility etc. causes QI and blood in length and breadth, foul smell blood stasis, multiple abscess anus, lump formation due to accumulation of pathogens
Into hemorrhoid.Eating and drinking without temperance, surfeit are pungent, production of dryness-heat in the interior, and gas is compeled blood stasis and swollen and ache.Doctor trained in Western medicine thinks, earns, firmly lift during defecation under exerting oneself
Weight or cough, cause anus edge angiorrhexiss, and in subcutaneous formation enclosed mass, the superfluous skin hypertrophy of anus edge forms external hemorrhoid to accumulation of blood.Feces
Retention, stimulates local to cause inflammation, outside internal hemorrhoid abjection anus, is clamped by sphincter, and venous return is obstructed, but arterial blood is still constantly defeated
Enter, the internal hemorrhoid hyperemia of abjection, volume is constantly increased, until the arterial blood of input is pressed to cause blood stasis to be formed.Primary disease it is common go out
The three big symptom such as blood, pain, constipation, easily patient suffering and recurrence.
The traditional Chinese medical science to the method for the treatment of of hemorrhoid based on external treatment, its unique non-operative treatment compared with doctor trained in Western medicine operative therapy have it is bright
Aobvious advantage.Operative therapy technical requirements and costly, and Post operation easily occur pain, bleeding, infection, wound healing it is slow,
The complication such as anus edge edema；And traditional Chinese medical science non-operative treatment can then avoid similar complication from occurring, the method is simple to operate in addition, again may be used
Mitigate patient's pain, be particularly well-suited to the patient of age, body void.Traditional Chinese medical science non-operative treatment be also at present treat operative therapy it is concurrent
The best approach of disease.Certainly, there is dosage inequality in Traditional Chinese Medicine non-operative treatment such as fumigation and wash method method, method of topical application, turunda method etc.
Weighing apparatus, Different therapeutical effect are big, the defect such as patient medication inconvenience, poor compliance.Therefore, exploitation facilitate patient using Chinese medicine control hemorrhoid system
Agent is the inevitable choice combined with modern Chinese medicine preparation technique by the traditional non-operative treatment of the traditional Chinese medical science.
The Chinese crude drug of famous and precious or resource scarcity being used the prescriptions of Chinese medicine of existing treatment hemorrhoid, such as more：Moschus, Lignum Aquilariae Resinatum, Fel Ursi,
Sanguis Draxonis, Squama Maniss etc..At present, contain in MAYINGLONG MUSK HEMORRHOID UNGUENTUM, bear's gall ointment and the anus Thailand sold on domestic market
Moschus, Fel Ursi hemorrhoid spirit cream prescription use Fel Ursi, and JINGWANHONG ZHICHUANG GAO prescription uses Sanguis Draxonis and Squama Maniss；Patents are such as
CN1546084A, CN102697836A, CN103071008A etc. also imitate similar prescription one after another.In addition, using drug effect to improve
Really, convergence putrefaction removing effect, or even the toxic herb material, such as CN1679722A such as the Calomelass used in prescription, Hydrargyri Oxydum Rubrum, Vermilion are strengthened.
To sum up, consume famous and precious or resource scarcity Chinese crude drug in a large number, can introduce that medical supply is unbalance and its quality is unstable at any time etc. can not
Control factor, causes stern challenge to drug quality and price, and the use of the toxic traditional Chinese medicine material such as Calomelass, Hydrargyri Oxydum Rubrum, Vermilion is even more
Allow patient to hang back, and the use of the strong medical material of blood-activating and qi-promoting power such as Moschus, Sanguis Draxonis, Squama Maniss is not suitable for age of sucking and pregnant yet
Phase patient, has further limited to promotion and application of the Chinese medicine in terms of hemorrhoid are controlled.
The content of the invention
The limitation existed based on background technology and deficiency, the invention provides a kind of Chinese medicine suppository and its system for treating hemorrhoid
Preparation Method.The Chinese medicine suppository prescription of the present invention adopts conventional, nontoxic, inexpensive Chinese crude drug, the prescription have infection by force, pain relieving
The characteristics of detumescence is fast, quick-acting safe.Suitable for the treatment of internal hemorrhoid and internal hemorrhoid postoperative complication, suckling is more particularly applied to
Phase and pregnant patients.
A kind of Chinese medicine suppository for treating hemorrhoid that the present invention is provided, its raw material include：Chinese medicine composition, vegetable oil and base
Matter, Chinese medicine composition include by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, Radix Et Rhizoma Rhei
0.6～2.0 part, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.
Preferably, vegetable oil be soybean oil, Oleum Brassicae campestriss, one or more compositionss in Oleum Sesami.
Preferably, substrate be cocoa butter, semi-synthetic fatty acid ester, in mixed fatty glycerides one or two with
Upper compositionss.
Preferably, the weight ratio of Chinese medicine composition and vegetable oil is 1:2～6.
Preferably, the weight ratio of substrate and vegetable oil is 3～5:1.
Preferably, Chinese medicine composition includes by weight：1.0 parts of Cortex Phellodendri, 1.0 parts of Rhizoma Coptidis, 1.0 parts of Radix Scutellariae, Radix Et Rhizoma Rhei 1.0
Part, 1.0 parts of Flos Lonicerae, 1.0 parts of Radix Sanguisorbae, 1.0 parts of Galla Chinensiss, 0.5 part of Borneolum Syntheticum.
The preparation method of the Chinese medicine suppository of the above-mentioned treatment hemorrhoid that the present invention is also proposed, comprises the steps：By Cortex Phellodendri, Huang
Company, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 1～3h, be then heated to 80～110 in adding vegetable oil
DEG C, 1～3h to be extracted, then is warming up to 120～150 DEG C, extract 0.2～1h, filtered, filtrate is cooled to 70 DEG C～100 DEG C, adds base
Matter mix homogeneously, is subsequently cooled to 40～80 DEG C, adds injection molding, cooling after the Borneolum Syntheticum mix homogeneously of powder, and obtain medical treatment hemorrhoid
The Chinese medicine suppository of skin ulcer.
The present invention adopts Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, eight taste medicinal material composition of Galla Chinensiss and Borneolum Syntheticum,
There is clearing away heat and loosing the bowels, hemostasis, reducing swelling and alleviating pain.Wherein Cortex Phellodendri bitter in the mouth, cold in nature；With heat clearing and damp drying, eliminating fire and detoxication, removing toxic substances
Treat effect of skin ulcer.Rhizoma Coptidis bitter in the mouth, it is cold in nature；There is clearing away heat-fire, dampness, removing toxic substances.Radix Scutellariae bitter in the mouth, it is cold in nature；With heat clearing away
Pathogenic fire purging, dampness removing toxic substances, hemostasis, antiabortive effect, have antibacterial, antiinflammatory, antioxidation, resistance state concurrently and strengthen immunocompetence effect.
Radix Et Rhizoma Rhei bitter in the mouth, it is cold in nature；Have functions that to attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, removing toxic substances.Radix Sanguisorbae bitter in the mouth, acid, puckery, cold nature；Tool
There are cooling blood for hemostasis, removing toxic substances sore, have hemostasis, antibacterial, antiviral and antiinflammatory action concurrently.It is Galla Chinensiss sour in the mouth, puckery, it is cold in nature；
There is astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore.Flos Lonicerae sweet in the mouth, it is cold in nature；With heat-clearing and toxic substances removing,
Effect of dispelling wind and heat pathogens.Borneolum Syntheticum acrid in the mouth, hardship, are slightly cold；There is inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain.
Based on Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, this four medicine is shared the medicinal material composition of the present invention, heat-clearing and toxic substances removing, pathogenic fire purging
The power of dampness is strong, assaults the main target " rheumatism pathogenic dryness-heat ", and eliminating evil is consolidated.In addition, being aided with Galla Chinensiss, Radix Sanguisorbae strengthens convergence, anastalsis,
Strengthen radiating analgesic efficacy with Flos Lonicerae, Borneolum Syntheticum again, it is to take stopgap measures that this four medicine is shared, for alleviating hemorrhoid symptom, mitigate patient
Pain.
Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Galla Chinensiss, Radix Sanguisorbae and Flos Lonicerae used by of the invention is domestic ecosystem road real estate
Medical material or the prepared slices of Chinese crude drugs, quality meet current edition Chinese Pharmacopoeia requirement.
The Chinese medicine suppository Jing hospital clinical research of the present invention, in August, 2013 add up treatment hemorrhoid patients in May, 2016
114 people, male 62 people, 52 people of female, age are minimum 17 years old, and maximum 73 years old, the course of disease is most short 3 weeks, most long 13 years, and (anemia of pregnant woman 5 for 68 people of internal hemorrhoid
People, 11 people of women breast-feeding their children), 46 people of internal hemorrhoid post-operative complication (12 people of women breast-feeding their children), medication 1～4 week, cure 100, show
, effective 6, invalid 0, there is no untoward reaction in effect 8, patient's compliance is good during medication.Present invention treatment is effective
Rate 100%.
The present invention stresses heat-clearing and toxic substances removing, purging intense heat eliminating dampness based on Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei；And Galla Chinensiss, Radix Sanguisorbae side
Again convergence, hemostasis and pain-relieving；And Flos Lonicerae, Borneolum Syntheticum then main scattered stasis pain, detumescence, granulation promoting.
" Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Galla Chinensiss, Radix Sanguisorbae, Flos Lonicerae " used by the present invention is domestic ecosystem road
Ground Chinese crude drug or the prepared slices of Chinese crude drugs, meet《Chinese Pharmacopoeia》One requirement of version in 2015.
Relative to prior art, the present invention has advantages below：
1st, medical material of the present invention is conventional cheap medical material or the prepared slices of Chinese crude drugs, and ample supply of commodities on the market, quality are guaranteed；
2nd, Chinese medicinal ointment therapeutic domain of the invention is wide, it is adaptable to the treatment of internal hemorrhoid and internal hemorrhoid postoperative complication；
3rd, Chinese medicinal ointment safe without toxic side effect of the invention, good patient compliance are adapted to crowd extensively, are particularly suited for feeding
Newborn phase and pregnant patients；
4th, Chinese medicine suppository of the invention is rapid-action, and pain relieving, hemostasis, detumescence effect are good, and medication can be stopped blooding for 3 minutes, 15 points
Clock eliminates pain, starts within 60 minutes detumescence, and a drug can maintain curative effect 6h, medication lump to be completely eliminated within 1～3 week, control
Cycle is short is treated, treated effect is high.
Specific embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment 1
Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae 50g, Radix Et Rhizoma Rhei 50g, Flos Lonicerae 50g, Radix Sanguisorbae 50g, Galla Chinensiss 75g, Borneolum Syntheticum
25g, soybean oil 2000g, cocoa butter 10000g.
Preparation method：Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, is soaked in adding soybean oil
Bubble 2h, is then heated to 90～100 DEG C, extracts 2h, then is warming up to 135～145 DEG C, extracts 0.5h, filters, and filtrate is cooled to 80
DEG C, cocoa butter mix homogeneously is added, 50～60 DEG C are subsequently cooled to, the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding is added
Cooling, obtains final product.
Embodiment 2
Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae 50g, Radix Et Rhizoma Rhei 50g, Flos Lonicerae 50g, Radix Sanguisorbae 50g, Galla Chinensiss 75g, Borneolum Syntheticum
25g, soybean oil 2000g, cocoa butter 5000g, mixed fatty glycerides 2000g.
Preparation method：Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, is soaked in adding soybean oil
Bubble 2h, is then heated to 90～100 DEG C, extracts 2h, then is warming up to 135～145 DEG C, extracts 0.5h, filters, and filtrate is cooled to 80
DEG C, add cocoa butter to mix homogeneously with mixed fatty glycerides, be subsequently cooled to 50～60 DEG C, add the powder of 120 mesh
Shape Borneolum Syntheticum mix homogeneously, injection molding cooling, obtains final product.
Embodiment 3
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 75g, Borneolum Syntheticum 25g, Oleum Sesami 1500g, mixing-in fat acid glycerol
Ester 5000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Sesami, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, added mixed fatty glycerides mix homogeneously, then cool down
The powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling to 50～60 DEG C, is added to obtain final product.
Embodiment 4
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 75g, Borneolum Syntheticum 25g, Oleum Sesami 1500g, mixing-in fat acid glycerol
Ester 4000g, cocoa butter 1000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Sesami, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add mixed fatty glycerides to mix with cocoa butter
It is even, 50～60 DEG C are subsequently cooled to, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling to obtain final product.
Embodiment 5
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 50g, Borneolum Syntheticum 50g, Oleum Brassicae campestriss 2400g, semi-synthetic fatty acid
Ester 9000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Brassicae campestriss, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, added semi-synthetic fatty acid ester mix homogeneously, be subsequently cooled to
50～60 DEG C, the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling is added to obtain final product.
Embodiment 6
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 50g, Borneolum Syntheticum 50g, Oleum Brassicae campestriss 2400g, semi-synthetic fatty acid
Ester 6000g, cocoa butter 2000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Brassicae campestriss, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, is filtered, filtrate is cooled to 80 DEG C, add semi-synthetic fatty acid ester to mix homogeneously with cocoa butter,
50～60 DEG C are subsequently cooled to, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling to obtain final product.
Embodiment 7
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Sesami 1500g, cocoa butter 6000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Sesami, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, added cocoa butter mix homogeneously, be subsequently cooled to 50～60
DEG C, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling to obtain final product.
Embodiment 8
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Sesami 1500g, cocoa butter 3000g,
Semi-synthetic fatty acid ester 1500g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Sesami, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, is filtered, filtrate is cooled to 80 DEG C, add cocoa butter, semi-synthetic fatty acid ester mix homogeneously,
50～60 DEG C are subsequently cooled to, add the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding cooling to obtain final product.
Embodiment 9
A kind of Chinese medicine suppository for treating hemorrhoid proposed by the present invention, its raw material include：Cortex Phellodendri 100g, Rhizoma Coptidis 100g, Radix Scutellariae
100g, Radix Et Rhizoma Rhei 100g, Flos Lonicerae 100g, Radix Sanguisorbae 100g, Galla Chinensiss 100g, Borneolum Syntheticum 50g, Oleum Sesami 1500g, cocoa butter 2000g,
Semi-synthetic fatty acid ester 1500g, mixed fatty glycerides 2000g.
The preparation method of the Chinese medicine suppository of above-mentioned treatment hemorrhoid that the present invention is also proposed, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei,
Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, and soak 2h, be then heated to 90～100 DEG C in adding Oleum Sesami, are extracted 2h, then are warming up to
135～145 DEG C, 0.5h is extracted, filtered, filtrate is cooled to 80 DEG C, add cocoa butter, semi-synthetic fatty acid ester, mixing-in fat
Acid glyceride mix homogeneously, is subsequently cooled to 50～60 DEG C, adds the powder Borneolum Syntheticum mix homogeneously of 120 mesh, injection molding to cool down, i.e.,
.
Chinese medicine suppository for treating hemorrhoid obtained by the present invention carries out pharmacodynamic study：
I, zoopery：
1st, rat foot claw swelling test：SD rats 60 are taken, body weight 180-200g, male are randomly divided into model group, blank
Matched group, positive controls (GANGTAISHUAN), high dose group of the present invention (concentration is 0.14g crude drugs/g ointment), middle dosage of the present invention
Group (0.07g crude drugs/g ointment), low dose group of the present invention (concentration is 0.04g crude drugs/g ointment), 10 per group.Respectively at per only
Corresponding medicine, 0.4g ointment/(foot plantar uniform application is defined) are given in Rat Right foot plantar local；Model group to distilled water,
Once a day, rat foot volume is measured as rat before administration with glass container method in first 1 hour in successive administration 5 days, administration in the 5th day
Sufficient volume, only causes inflammation in each Mus right hind foot 1% carrageenin 0.1ml/ of plantar subcutaneous injection in 0.5 hour after administration, subsequently respectively
It is every to determine once sufficient plantar volume, METHOD FOR CONTINUOUS DETERMINATION 6 times every other hour.Deduct before administration the result that each time period determines after inflammation is caused
Measured value is sufficient pawl swelling degree, and its result is as follows：
Table 1-1 impacts of the present invention to rat foot claw swelling (N=10)
Table 1-2 impacts of the present invention to rat foot claw swelling (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：The paw swelling that the present invention can substantially mitigate rat in 1 hour upon administration, is continued until
6h, and compare with model group, blank control group, with significant difference.
2nd, the ear swelling test of mice：
60 mices are taken, body weight 18-22g, male and female half and half are randomly divided into 6 groups：Model group, blank control group (substrate), sun
Property matched group (GANGTAISHUAN), high dose group of the present invention (concentration be 0.14g crude drugs/g ointment), middle dose group of the present invention (0.07g lifes
Medicine/g ointment), low dose group of the present invention (concentration be 0.04g crude drugs/g ointment), 10 per group.Corresponding each group is applied in mouse right ear
Medicine, 0.2g ointment/only, once a day, continuous 5 days, 30min after last dose, before and after mouse right ear, two sides applies 100%
Only, left ear does not make any process to caused by dimethylbenzene xylene inflammation liquid 0.02ml/, and animal is put to death after 4 hours, cuts ears immediately, is punched with 8mm
Device takes same area auricle, weighs on analytical balance, deducts left auricle weight as swelling with auris dextra sheet weight, with (auris dextra
Weight-left ear weight)/left ear weight is swelling rate, its result is as follows：
Impact of 2 present invention of table to mice ear (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：The present invention can substantially suppress the ear swelling degree and ear swelling rate of mice, and with model group, blank
Matched group compares, with significant difference.
3rd, hot plate method in mice test：
Hot plate is preheated 10min in (55 ± 0.5) DEG C by the temperature of regulating thermostatic water-bath.18-22g female mices are taken, every time
1 is merely placed on hot plate, and mice is placed on the pain threshold of (s) as the Mus the time required to hot plate up to occurs licking metapedes certainly.It is all lick after
The sufficient time is less than 5s or is more than 30s or leaper, gives it up.60 qualified mices are divided equally into 6 groups at random：Model group, sky
White matched group (substrate), positive controls (GANGTAISHUAN), high dose group of the present invention (concentration is 0.14g crude drugs/g ointment), this
Bright middle dose group (concentration is 0.07g crude drugs/g ointment), low dose group of the present invention (concentration is 0.04g crude drugs/g ointment), per group
10.Relative medicines are applied respectively at four sufficient plantars, 0.2g ointment/only, once a day, successive administration 5 days, 60 after last dose,
90th, 120min determines mice pain threshold respectively, and such as 60s is still reactionless, and mice is taken out, in order to avoid scalding, its pain threshold is based on 60s
Calculate, it is as a result as follows：
Impact that 3 present invention of table is tested to mouse hot-plate (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：1～1.5h upon administration of the invention can significantly improve the pain threshold of mice, and to mice pain after 2h
Threshold value changes unobvious.
4th, mouse writhing test：
Take 60 mices and divide equally 6 groups at random：Model group, blank control group (substrate), positive controls (GANGTAISHUAN), this
Bright high dose group (concentration is 0.14g crude drugs/g ointment), middle dose group of the present invention (concentration is 0.07g crude drugs/g ointment), this
Bright low dose group (concentration is 0.04g crude drugs/g ointment), 10 per group.Rectally, administered volume 0.2g ointment/only, daily
Once, continuous 5 days, start within 1 hour after last dose test.Test mice lumbar injection 1mol/L glacial acetic acid 10ml/kg causes to turn round
Body, each group mouse writhing number of times in record 15min, its result are as follows：
Impact of 4 present invention of table to mouse writhing number of times (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：After present invention administration, mouse writhing number of times has certain reduction, with model group, blank control group
Relatively, with significant difference.
5th, mice docking test：
Mice 60 is taken, male and female half and half are randomly divided into 6 groups：Model group (distilled water), blank control group (substrate), the positive
(concentration is for matched group (GANGTAISHUAN), high dose group of the present invention (concentration be 0.14g crude drugs/g ointment), middle dose group of the present invention
0.07g crude drugs/g ointment), low dose group of the present invention (concentration be 0.04g crude drugs/g ointment), 10 per group.Mice is placed in into spy
Cut tail 0.5cm to clock in the holder of system immediately, smear corresponding medicine 0.2g ointment/only after docking immediately, and use stopwatch meter
When, drop of blood is sucked every 30S filter paper, to no longer bleeding, record the bleeding time.
Compare with model group and blank control group, the bleeding time of high, medium and low dosage group mice significantly shortens, difference
There is significance (P<0.01).Its result is as follows：
5 present invention of table to mice dock the bleeding time impact (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：After mice docking, three groups of bleeding times significantly shorten.
6th, rat Perianal ulceration model test：
60 rats are taken, male and female half and half, all animals first stick anus, filter paper with the filter paper for being soaked with 99% acetum
Piece need to be in close contact anal skin and mucosa, and every Mus paste 1min with 2 filter papers.That afternoon observes ulcer level, by body
60 rats are randomly divided into 6 groups by weight and ulcer level：Model control group (distilled water), blank control group (substrate), the positive are right
According to group (GANGTAISHUAN), high, medium and low dosage group of the invention, crissum smears medicine 0.4g ointment/only, once a day, successive administration 5d,
Observation the 3rd, 5,7,9 days rat ulcer healing situations of administration, evaluate ulcer level.
Rat Perianal ulceration standards of grading：There is 1 point of ulcer sepage；2 points of a little ulcer sepage；There is eschar to heal substantially 3 points；
Heal 4 points completely.
Its result is as follows：
Impact of 6 present invention of table to rat Perianal ulceration (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：The present invention can obviously reduce rat Perianal ulceration score value, and and model after administration 5 days
Group, blank control group compare, with significant difference.
7th, rat experimental hemorrhoid model test：
Compare with model group and blank control group, the present invention is high, middle dose group 24h after to l% carrageenin starts, can
The swelling of rat crissum is reduced substantially, low dose group 96h after to l% carrageenin can obviously reduce the swollen of rat crissum
Expansibility.
Impact of 7 present invention of table to rat experimental hemorrhoid (N=10)
Compare with model group, * P<0.05, * * P<0.01；Compare with blank control group,ΔP<0.05,ΔΔP<0.01
As seen from the above table：The present invention upon administration 24h start the swelling that can obviously reduce rat crissum, with model group,
Blank control group compares, with significant difference.
II, human clinical trial：
1st, treat internal hemorrhoid curative effect：
Choose 136 and make a definite diagnosis internal hemorrhoid patient, maximum 73 years old, minimum 19 years old, 5 people of anemia of pregnant woman, 11 people of women breast-feeding their children are divided into two
Group, in experimental group, other random packets, Jing statistics confirm two groups of ages, diseases for per group of 68 people, wherein anemia of pregnant woman, women breast-feeding their children
There was no significant difference for journey, and two groups of diet, daily life systems are consistent, and wherein experimental group is daily using stype in present invention gained
Agent, once a day；Matched group uses GANGTAISHUAN, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 68 | 66 | 2 | 0 | 0 | 100% |
| Matched group | 68 | 56 | 4 | 2 | 6 | 91.2% |
Wherein curative effect determinate standard：
(1) symptom, the sign of fully recovering disappears or basic disappearance, and integrated value reduces more than >=95%, and related physical and chemical index should be just
It is normal or normal.
(2) effective symptom, sign are obviously improved, and integrated value reduces >=70%, and related physical and chemical index is obviously improved.
(3) effectively symptom, sign take a favorable turn, and integrated value reduces >=30%, and related physical and chemical index accordingly takes a turn for the better.
(4) invalid symptom, sign do not improve, and integrated value reduces ＜ 30%, and related physical and chemical index is without improvement.
As seen from the above table：The present invention is better than prior art to the total effective rate of external hemorrhoid.
2nd, internal hemorrhoid post-operative treatment curative effect：
Choose 92 and make a definite diagnosis postoperation patient, maximum 64 years old, minimum 17 years old, 12 people of women breast-feeding their children is random to be grouped,
Per group of 46 people, in experimental group, other random packets, Jing statistics confirm two groups of ages, courses of disease without notable to wherein women breast-feeding their children
Sex differernce.Two groups of diet, daily life systems are consistent, wherein experimental group daily using the present invention gained Chinese medicine suppository, daily one
It is secondary；Matched group uses GANGTAISHUAN, once a day.As a result it is as follows：
| n | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Experimental group | 46 | 34 | 6 | 6 | 0 | 100% |
| Matched group | 46 | 29 | 3 | 3 | 10 | 78.3% |
As seen from the above table：The present invention is better than prior art to the total effective rate of postoperation.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept equivalent or change in addition, should all be included within the scope of the present invention.
Claims (7)
1. a kind of Chinese medicine suppository for treating hemorrhoid, it is characterised in that its composition includes：Chinese medicine composition, vegetable oil and substrate.Its
Middle Chinese medicine composition includes by weight：0.6～2.0 part of Cortex Phellodendri, 0.6～2.0 part of Rhizoma Coptidis, 0.6～2.0 part of Radix Scutellariae, Radix Et Rhizoma Rhei 0.6
～2.0 parts, 0.6～2.0 part of Flos Lonicerae, 0.6～2.0 part of Radix Sanguisorbae, 0.6～2.0 part of Galla Chinensiss, 0.3～1.0 part of Borneolum Syntheticum.
2. the Chinese medicine suppository of hemorrhoid is treated according to claim 1, it is characterised in that vegetable oil is soybean oil, Oleum Brassicae campestriss, fiber crops
One or more compositionss in oil.
3. according to any one of claim 1-2 treat hemorrhoid Chinese medicine suppository, it is characterised in that substrate be cocoa butter,
One or more compositionss in semi-synthetic fatty acid ester, mixed fatty glycerides.
4. the Chinese medicine suppository of hemorrhoid is treated according to any one of claim 1-3, it is characterised in that Chinese medicine composition and plant
The weight ratio of oil is 1:2～6.
5. the Chinese medicine suppository of hemorrhoid is treated according to any one of claim 1-4, it is characterised in that the weight of substrate and vegetable oil
Amount is than being 3～5:1.
6. the Chinese medicine suppository of hemorrhoid is treated according to any one of claim 1-5, it is characterised in that Chinese medicine composition is by weight
Part includes：1.0 parts of Cortex Phellodendri, 1.0 parts of Rhizoma Coptidis, 1.0 parts of Radix Scutellariae, 1.0 parts of Radix Et Rhizoma Rhei, 1.0 parts of Flos Lonicerae, 1.0 parts of Radix Sanguisorbae, Galla Chinensiss
1.0 parts, 0.5 part of Borneolum Syntheticum.
7. it is a kind of as described in any one of claim 1-6 treat hemorrhoid Chinese medicine suppository preparation method, it is characterised in that include
Following steps：Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Flos Lonicerae, Radix Sanguisorbae, Galla Chinensiss are crushed, in adding vegetable oil, 1～3h is soaked,
80～110 DEG C are then heated to, 1～3h are extracted, then is warming up to 120～150 DEG C, extract 0.2～1h, filtered, filtrate is cooled to
70 DEG C～100 DEG C, substrate mix homogeneously is added, 40～80 DEG C are subsequently cooled to, noted after adding the Borneolum Syntheticum mix homogeneously of powder
Mould is cooled down.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611024346.0A CN106552065A (en) | 2016-11-17 | 2016-11-17 | It is a kind of to treat Chinese medicine suppository of hemorrhoid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096402A (en) * | 2018-01-02 | 2018-06-01 | 薛保玉 | A kind of stype with good anti-inflammatory analgetic hemostasia effect and preparation method thereof |
| CN108721461A (en) * | 2017-04-21 | 2018-11-02 | 上海市金山区中西医结合医院 | It is a kind of to hold back the scattered preparation method of hemorrhoid |
-
2016
- 2016-11-17 CN CN201611024346.0A patent/CN106552065A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 江顺奎等: "四黄痔疮膏的制备及临床应用", 《中医外治杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721461A (en) * | 2017-04-21 | 2018-11-02 | 上海市金山区中西医结合医院 | It is a kind of to hold back the scattered preparation method of hemorrhoid |
| CN108096402A (en) * | 2018-01-02 | 2018-06-01 | 薛保玉 | A kind of stype with good anti-inflammatory analgetic hemostasia effect and preparation method thereof |
| CN108096402B (en) * | 2018-01-02 | 2021-01-05 | 薛保玉 | Stype with good anti-inflammatory, analgesic and hemostatic effects and preparation method thereof |
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Application publication date: 20170405 |