CN108096402B

CN108096402B - Stype with good anti-inflammatory, analgesic and hemostatic effects and preparation method thereof

Info

Publication number: CN108096402B
Application number: CN201810021813.7A
Authority: CN
Inventors: 薛保玉; 薛卜玮; 薛淼淼; 崔素燕
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-01-02
Filing date: 2018-01-02
Publication date: 2021-01-05
Anticipated expiration: 2038-01-02
Also published as: CN108096402A

Abstract

The invention discloses a stype with good anti-inflammatory, analgesic and hemostatic effects and a preparation method thereof, wherein the stype is prepared from the following components in parts by weight: 2-15 parts of cassia twig, 2-15 parts of rhizoma corydalis, 5-16 parts of sanguisorba officinalis, 2-10 parts of rhizoma acori graminei, 2-10 parts of borneol, 2-10 parts of radix sileris, 1-10 parts of gallnut, 2-12 parts of angelica sinensis, 2-12 parts of pseudo-ginseng and 2-16 parts of indometacin. The invention effectively solves the problems of great toxic and side effects of the western medicine taken alone and poor treatment effect of the traditional Chinese medicine taken alone. The medicine has the effects of relieving spasm and pain, resisting inflammation and removing toxicity, promoting blood circulation to remove blood stasis, stopping bleeding and enriching blood, is administered by selecting anus and rectum, is combined with the walking and penetrating effect of the aromatic resuscitation inducing medicine, transmits the effective components of the medicine to various tissues and organs to regulate and nourish the organism, relieves the harm of western medicines to organs such as stomach, intestine, liver, kidney, heart and brain, is convenient to administer, quick to absorb, quick to take effect, good in pain relieving effect, small in toxic and side effects, free of addiction, dependence and safe and reliable, and is an ideal medicinal suppository with the effects of relieving spasm and pain, promoting blood circulation to remove blood stasis, stopping bleeding and resisting inflammation.

Description

Stype with good anti-inflammatory, analgesic and hemostatic effects and preparation method thereof

Technical Field

The present invention relates to an anti-inflammation pain-relieving hemostatic suppository which is made up by using Chinese medicine and Western medicine as raw material and its preparation method.

Background

The etiology and pathology of pain are different, and the nature and degree of pain are different, so that the pain and the injury of patients are great. Has become a worldwide medical problem. Bringing great challenges to medical workers. Most of the existing analgesic drugs commonly used in the medical field are western medicines. It can be divided into 1 non-steroidal anti-inflammatory drug, 2 central analgesic (belonging to two classes of psychotropic drugs), 3 anesthetic analgesic (morphine, etc.), 4 antispasmodic analgesic (atropine, etc.), 5 anxiolytic drug. The administration routes are as follows: oral, intramuscular, intravenous or pump drip, anorectal suppository and the like. The drugs have not ideal analgesic effect, but also have damage to the stomach, intestine, liver and kidney to different degrees or certain addiction. Additionally, suppositories are now commonly used for analgesia: indomethacin suppository, diclofenac suppository, indozolidon suppository, etc. The components of the medicine are western medicines, and the pain relieving effect and the toxic and side effect are not obviously improved. The analgesic drugs of the Chinese medicinal preparation comprise oral drugs, external drugs, suppositories and the like. The analgesic effect is not obvious, or the side effect and addiction are not small.

Disclosure of Invention

The invention provides a stype with good anti-inflammatory, analgesic and hemostatic effects, which overcomes the defects in the prior art.

In order to realize the purpose of the invention, the stype with good anti-inflammatory, analgesic and hemostatic effects is characterized by being prepared from the following components in parts by weight:

2-15 parts of cassia twig, 2-15 parts of rhizoma corydalis, 5-16 parts of sanguisorba officinalis, 2-10 parts of rhizoma acori graminei, 2-10 parts of borneol, 2-10 parts of radix sileris, 1-10 parts of gallnut, 2-12 parts of angelica sinensis, 2-12 parts of pseudo-ginseng and 2-16 parts of indometacin.

The preferable weight parts of the components are as follows:

3-9 parts of cassia twig, 5-12 parts of rhizoma corydalis, 10-12 parts of garden burnet, 2-6 parts of rhizoma acori graminei, 3-8 parts of borneol, 3-9 parts of divaricate saposhnikovia root, 2-8 parts of gallnut, 3-8 parts of Chinese angelica, 3-9 parts of pseudo-ginseng and 5-10 parts of indometacin.

The optimal weight part ratio of the components is as follows:

5 parts of cassia twig, 9 parts of rhizoma corydalis, 8 parts of garden burnet root, 3 parts of Chinese gall, 3 parts of rhizoma acori graminei, 5 parts of borneol, 5 parts of Chinese angelica, 5 parts of divaricate saposhnikovia root, 6 parts of pseudo-ginseng and 8 parts of indometacin.

The preparation method of the stype with good anti-inflammatory, analgesic and hemostatic effects is characterized by comprising the following steps:

heating and melting mixed fatty glyceride, sequentially adding corydalis tuber, divaricate saposhnikovia root, cassia twig, garden burnet root, Chinese gall, Chinese angelica, pseudo-ginseng and grassleaf sweelflag rhizome, continuously heating until the components are brown or black brown, filtering to remove residues, cooling to 80 +/-5 ℃, adding borneol, stirring until the borneol is melted, adding indometacin powder, continuously stirring uniformly, pouring into a mold, and cooling to room temperature, wherein the weight part ratio of the mixed fatty glyceride to the components is 3: 1-2: 1.

The invention has the following effects:

cassia twig: pungent, sweet and warm. It enters lung, spleen, heart and bladder meridians. Has effects of warming and dredging channels and collaterals, tonifying yang, regulating qi, warming yang, relieving pain, and warming blood. The oleum Cinnamomi can dilate blood vessel, improve blood circulation and cardiac function, tranquilize, relieve convulsion, resist tumor, inflammation and allergy, and inhibit Staphylococcus aureus, Escherichia coli, Bacillus anthracis, influenza virus, etc.

Wind prevention: pungent, sweet and slightly warm. It enters bladder, liver and spleen meridians. Has effects in expelling pathogenic wind, eliminating dampness, relieving pain, relieving spasm, dredging meridians, promoting blood circulation, and dredging tendons and bones. Has antipyretic, antiinflammatory, tranquilizing, analgesic, anticonvulsive, and antiallergic effects.

Rhizoma corydalis (corydalis tuber): pungent, bitter and warm. Enters liver, spleen and heart channels, and has the effects of promoting blood circulation, removing blood stasis, promoting qi circulation, relieving pain and the like. Rhizoma corydalis is warm and smooth, pungent, moist and dispersing, and can smooth blood vessels, eliminate blood stasis, disperse qi stagnation, dredge vessels and stop pain. Move qi and blood, activate qi and blood, and relieve pain. Can relieve various pains, has obvious effects of dilating blood vessels and lowering blood pressure, and has certain antibacterial, anti-inflammatory and anti-tumor effects. Modern pharmacological studies have confirmed that: 15 alkaloids can be separated from rhizoma corydalis, wherein tetrahydropalmatine, Pharbitidis and decatetrahydropalmatine have analgesic effect, especially tetrahydropalmatine has analgesic and sedative effects. Dehydro-eleutherine A has effects of increasing coronary blood flow and myocardium nutritional blood flow, and preventing myocardial ischemia. The subcutaneous injection of dehydrocorydaline has certain protection effect on experimental gastric ulcer of rat, especially gastric ulcer induced by pylorus ligation or aspirin, and has inhibition effect on gastric secretion and gastric acid.

Chinese angelica: sweet, pungent and slightly bitter, enter heart, liver and spleen meridians. Has the effects of promoting blood circulation, replenishing blood, warming and activating meridian, relieving pain, relieving spasm, etc., can keep the body and enter liver to generate yin, activate yang, nourish blood, promote blood circulation, and move spleen channel to remove qi stagnation and disperse essence to regulate qi and replenish blood. It is the essential herb for tonifying blood. Can be used for treating dizziness, palpitation, short breath, numbness, and pain due to blood vessel deficiency.

Garden burnet root: bitter, sour and slightly cold herbs enter liver, stomach and large intestine meridians, and have the efficacies of cooling blood, stopping bleeding, purging fire, detoxifying and the like, the garden burnet root has the bitter and cold property, moves down to the lower energizer, enters blood system, can clear and lower blood, astringe and stop bleeding, but clear but not discharge, and astringent but not stagnation, and is a good product for clearing heat and stopping bleeding. In vitro test shows that radix Sangusorbae has antibacterial effect on Escherichia coli, Bacillus dysenteriae, Bacillus proteus, Bacillus typhi, Bacillus paratyphi, Pseudomonas aeruginosa, Vibrio cholerae, Bacillus tuberculosis, and Diplococcus meningitidis.

Pseudo-ginseng: sweet, warm and slightly bitter, entering liver and kidney meridians, and has the effects of stopping bleeding, removing blood stasis, relieving swelling and pain and the like. Notoginseng is sweet and slightly bitter in taste, good in regulating ying and stopping bleeding, removing blood stasis and promoting tissue regeneration, activating stagnancy and dredging collaterals, and can stop bleeding, remove blood stasis and blood, regulate collaterals, remove blood stasis and promote tissue regeneration, and is the essential herb for blood syndrome. Has hemostatic effect and is effective for removing blood stasis. Simultaneously has the effects of relieving pain, warming and activating channels and collaterals, dissipating blood stasis, reducing swelling and the like.

Gallnut: sour, astringent and cold, entering large intestine and kidney meridians, has effects of astringing intestine, arresting discharge, stopping bleeding, removing toxic substance, and treating sore, and can be used for treating various blood diseases.

Grassleaf sweelflag rhizome: pungent and warm, entering heart, liver, spleen and kidney meridians, with the following actions: has effects of inducing resuscitation, dredging heart, refreshing mind, and clearing yang, and rhizoma Acori Graminei has effects of tranquilizing mind, refreshing brain, improving hearing and eyesight, eliminating dampness, promoting appetite, and regulating stagnation and Zhongzhou.

Borneol: pungent, bitter and slightly cold, entering heart, spleen and lung meridians, with the following effects: inducing resuscitation and refreshing mind, and pungent and fragrant smell moving, all the way up and down without reaching, and dredging and unblocking the heart orifice. Clearing heat and relieving pain, clearing heat and removing fire toxin, relieving pain and swelling, and removing nausea and promoting tissue regeneration. Is a good herb for refreshing, inducing resuscitation and alleviating pain.

The indometacin is a non-steroidal anti-inflammatory drug and has the effects of resisting inflammation, relieving fever and easing pain, wherein the effect of alleviating pain is obvious. Indomethacin is used for reducing synthesis of prostaglandin, inhibiting formation of pain nerve impulse of inflammatory tissues and inhibiting inflammatory reaction, including chemotaxis of cells, release of lysosomal enzyme and the like through inhibition of cyclooxygenase. Indomethacin also acts on hypothalamic thermoregulatory center, causing peripheral vasodilation and sweating, increasing heat dissipation and producing an antipyretic effect.

The formula mechanism of the invention is as follows:

1. the indomethacin can reduce the synthesis of prostaglandin through inhibiting cyclooxygenase, inhibit the formation of pain nerve impulse of inflammatory tissues, inhibit inflammatory reaction, inhibit chemotaxis of leucocytes and release of lysosomal enzyme and has good analgesic effect. Therefore, it is a main ingredient of the present preparation.

2. The rhizoma corydalis and the pseudo-ginseng have good analgesic effects, also have obvious effects of promoting blood circulation to remove blood stasis, activating stagnancy and dredging collaterals and the like, and can effectively increase blood flow of coronary artery and kidney, reduce myocardial oxygen consumption and damage to urinary system. At the same time, rhizoma corydalis has the functions of resisting gastric acid secretion and reducing gastric ulcer. Thus, the indometacin not only can reduce the damage to the cardiovascular system, the urinary system and the gastrointestinal mucosa, but also can expand the analgesic effect of the indometacin.

3. The grassleaf sweelflag rhizome is used for eliminating dampness, regulating stomach, lowering adverse qi and stopping vomiting as an assistant to relieve gastrointestinal reactions such as nausea and pantothenic acid, abdominal distension and pain, diarrhea and the like caused by indomethacin.

4. The effects of inducing astringency, stopping bleeding, detoxifying and the like of the garden burnet and the Chinese gall are used for resisting the side effect of indometacin on ulcer bleeding of various tissues and organs of a blood system, and meanwhile, the anti-inflammatory and detoxifying effects of the garden burnet and the Chinese gall can also play a good role in protecting intestinal mucosa.

5. The angelica has the effects of invigorating the blood circulation and enriching the blood to fill the vessels, and realizes the effects of invigorating the blood circulation without empty vessels and dredging the channels without stagnation together with the effects of inducing resuscitation and dredging the channels and the like of the borneol, thereby achieving the effect of dredging the channels without pain.

6. The functions of cassia twig, grassleaf sweelflag rhizome and Chinese angelica, such as ascending lucidity, heart yang activation, blood circulation activation and blood enriching are used for relieving the side effects of indometacin, such as dizziness, palpitation, short breath, tinnitus, insomnia and the like caused by the damage of nervous systems, such as heart, brain and the like.

7. The cassia twig and the divaricate saposhnikovia root have the effects of dispelling wind, calming, resisting allergy and the like, and can relieve the symptoms of dizziness, restlessness, limb rigidity and the like caused by the influence of indomethacin on a nervous system. Meanwhile, the cassia twig and the divaricate saposhnikovia root have the effects of calming endogenous wind, dredging collaterals, relieving spasm, penetrating bones and the like, so that the pain relieving effect of the traditional Chinese medicine is enhanced.

8. The pungent and fragrant smell of borneol is used to conduct the effective components of various medicines to the tissues and organs of the whole body quickly through the venation nerve to exert the maximum effect.

9. The borneol has the effects of dissipating heat, removing swelling and pain, removing malignant tissue, promoting tissue regeneration, detoxifying and stopping bleeding, stopping diarrhea, resisting ulcer and the like to prevent the indomethacin from damaging intestinal mucosa. And can effectively eliminate the bleeding pain, extravasated blood edema and inflammation of anorectal diseases. Has important function for promoting the recovery of anorectal diseases.

10. The suppository for anorectal administration can reduce the damage of oral medicaments to gastric mucosa, avoid the influence of gastric acid and the like on the efficacy of medicament components, and more importantly, avoid the circulation of liver and intestine and reduce the damage of indometacin to liver. And the blood vessels of the rectal mucosa are rich, and the medicament is quickly and thoroughly absorbed, so the dosage is small, the toxic and side effects are few, and the medicament is safe and effective.

Non-steroidal analgesic drugs are known to be one of the best choices in the field of medical pain because of their good analgesic effect, no addiction, good quality and low price. But greatly reduces the utilization rate of the medicine due to more side effects. In order to improve the condition, the invention starts from the whole aspect of the prescription, the administration route and the like, focuses on all tissues and organs of the whole body, reasonably utilizes the combination of Chinese and western medicines, and ensures that the analgesic effect is better and the toxic and side effects are less. According to the theories of 'obstruction causing pain and pain causing obstruction' of the traditional Chinese medicine and 'prostatitis inducing pain' of western medicine, and the like, a non-steroidal analgesic drug 'indomethacin' is selected as a main component, and is combined with traditional Chinese medicine components with the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain and the like, so that the pain relieving effect can be obviously enhanced, and more importantly, the influence of the toxic and side effects of the indomethacin on a human body can be prevented or relieved.

The invention aims to treat systemic diseases, is based on the basic theories of holism concept of traditional Chinese medicine and obstruction of pain, combines the characteristics of wide distribution of meridians in human bodies and the transmission, regulation and nourishing of meridians, and selects traditional Chinese medicine components with the effects of clearing and activating the channels and collaterals, promoting blood circulation to remove blood stasis, stopping bleeding and enriching blood, harmonizing stomach and lowering adverse qi, inducing resuscitation with aromatics and indomethacin with good anti-inflammatory and analgesic effects as raw materials to prepare the traditional Chinese medicine composition. The suppository has the advantages of convenient administration, quick absorption, good pain relieving effect, small dosage of the medicine, small toxic and side effect, wide application range and the like, and is an ideal suppository with the effects of relieving spasm and pain, activating blood circulation to dissipate blood stasis, stopping bleeding and resisting inflammation.

The suppository preparation of the invention has the following functions:

1. relieving spasm and pain, stopping bleeding, relieving inflammation, and promoting wound healing.

Can be used for conservative treatment of wound, inflammation, calculus and space occupying lesion of skull, thoracic cavity, abdominal cavity and trunk extremity, and postoperative pain relieving. For postoperative patients, the suppository can be plugged into the anus after the operation is finished, and generally has no pain process after waking. Especially for patients in perianal rectal operation, because of the medicine with the functions of detoxification and hemostasis, adverse reactions such as infection bleeding and edema are seldom generated.

2. Relieving spasm and pain, stopping bleeding, promoting blood circulation, removing toxic substance, relieving inflammation, eliminating swelling, and promoting granulation.

Can be used for the conservative treatment and postoperative treatment of hemorrhoid, fistula, anal fissure, proctoptosis, intestinal mucosa prolapse, and anorectal space occupying lesion. Meanwhile, the external hemorrhoid injection has the obvious effect of relieving internal hemorrhoid ligation or injection, external hemorrhoid stripping and internal hemorrhoid, intestinal mucosa repair and falling and swelling after the intrarectal space-occupying lesion excision suture and in the thread-off period. Especially has outstanding effects of relieving pain, stopping bleeding and resisting inflammation.

3. Relieving spasm and pain, promoting blood circulation for removing blood stasis, removing dampness and calming endogenous wind, etc.

Can be used for treating nervous and rheumatic diseases of limbs and trunk with good therapeutic effect.

The suppository is a suppository which is formed by the intensive research and exploration of five generations of people and is continuously improved and has the ideal effects of relieving recovery and pain, promoting blood circulation to remove blood stasis, stopping bleeding and resisting inflammation. The invention is called Xue's traditional Chinese medicine analgesic suppository for short, which has the following characteristics:

the medicine adopts the combined application of Chinese and western medicines, and effectively solves the problems of great toxic and side effects of the single western medicine and poor treatment effect of the single traditional Chinese medicine. The medicine has the effects of relieving spasm and pain, resisting inflammation, removing toxic substances, promoting blood circulation, removing blood stasis, stopping bleeding, replenishing blood, etc., and can be used for relieving the damage of western medicines to gastrointestinal, liver and kidney, heart and brain, etc. Has the characteristics of small toxic and side effect, no addiction, no dependence, safety, reliability, long action time, low cost and the like. The drug is administered by selecting anus and rectum, has the advantages of convenience, practicability and quick effect, and can take effect after about 10 minutes of relieving pain of rectum and abdomen. Especially for children and patients who take medicine inconveniently, the advantages are more prominent.

The invention discloses a Xue's traditional Chinese medicine analgesic suppository clinical effect observation: the traditional Chinese medicine composition has definite curative effect in various fields of acute and chronic pain, central and neuropathic pain, plane injury, inflammation, cancer and the like of tens of thousands of patients. In 2017, 2-10 months, respectively carrying out comparative observation in orthopedics department, anorectal department, obstetrical department and rheumatism and immunization department in a pain sensitive area of a certain hospital. Comparative analyses were performed by using different analgesic methods. The results are as follows:

1. and (3) observation of clinical curative effect of orthopedics: the selected cases were all patients after bone injury surgery, and total 115 cases were selected. The case criteria were selected: the patients without mental disturbance and physiological immunodeficiency are postoperative patients who voluntarily use the Xue's Chinese medicine analgesic suppository. The age is 10-75 years old, wherein 86 men account for 74.8 percent, and 29 women account for 25.2 percent. To eliminate individual differences, the same patient was selected to use different analgesic drugs alternately every day. The analgesic drug selected by the treatment group is an analgesic pump commonly used in the field of pain at present, and the Xue's Chinese traditional medicine analgesic suppository is selected by the observation group.

Pain was divided by the world health organization into the following 5 levels:

0 degree: no pain; i degree: mild pain, intermittent pain without using medicine; II degree: moderate pain, persistent pain affecting rest, requiring analgesics: and III degree: severe pain, persistent pain that cannot be alleviated without medication; IV degree: severe pain, persistent pain with changes in blood pressure, pulse, etc.

The 115 cases mentioned above were divided into four categories: wherein, the fracture of limbs accounts for 29.6 percent in 34 cases, 18.3 percent in 21 cases of males and 11.3 percent in 13 cases of females; 45.2% of 52 cases of lower limb complicated with pelvic fracture, wherein 42 cases of men account for 36.5% and 10 cases of women account for 8.7%; 18 patients with upper limb amputation account for 15.7 percent, wherein 16 patients in males account for 13.9 percent, and 2 patients in females account for 1.7 percent; 11 patients with lower limb amputation account for 9.6 percent, wherein 9 patients in males account for 7.8 percent, and 2 patients in females account for 1.7 percent.

The operation of all subjects adopts conventional anesthesia, and the operation adopts quiescent point broad spectrum antibiotics, hemostats and the like; orally taking the traditional Chinese medicine with the efficacies of replenishing qi and blood, strengthening spleen and tonifying kidney, setting fracture and stopping bleeding and the like; one half of the patients were randomly selected to ensure that each group had patients of different disease species. Two different methods of pain relief are used after the surgery is finished. The second day after surgery a different pain relief approach was used than the previous day. Among them, amputation is one type, and fracture is one type.

The summary case is: in the first category, patients with pain pumps had 5% of IV, 82% of III, and 13% of II pain; the Xue's Chinese medicine pain-relieving suppository has 1% of pain in III degree, 5% of pain in II degree, 57% of pain in I degree and 37% of pain in 0 degree. In all cases, pain gradually decreased with the duration of treatment. Patients who use the pain-relieving pump have the problem that the Xue's Chinese traditional medicine pain-relieving suppository is added when the pain is difficult to endure. The second category, the pain pump is used for treating 12% of IV-degree pain, about 78% of III-degree pain and 10% of II-degree pain; the Xue's Chinese medicine pain plug accounts for 2% of III degree pain, 8% of II degree pain, 67% of I degree pain and 23% of 0 degree pain. The medicament is used for amputation patients 2-3 times per day, and 2 capsules can be used for patients with obvious pain and heavy weight. All patients who have analgesic pumps use Xue's Chinese traditional medicine suppository for relieving pain when the pain is serious. Generally, the pain is gradually relieved after about 20 minutes. With the prolonged treatment time, the dosage can be reduced to 2 times per day, 1 granule each time. After the Xue's traditional Chinese medicine pain-relieving suppository is used, the mild dizziness and the upper abdominal discomfort are felt to be about 7 percent, and are mostly light patients or weak patients, and the mild dizziness and the upper abdominal discomfort disappear in about 1 hour without other discomfort symptoms.

2. Anorectal clinical efficacy observation: perianal diseases are mostly pain-sensitive areas of the spine nerve. Obvious pain and great pain-relieving difficulty. The selected cases are patients after perianal disease operation, and the total number of the cases is 128. The case criteria were selected: no mental disturbance, no physiological immunodeficiency, no serious heart, brain and kidney diseases. All are postoperative patients who voluntarily use the Xue's Chinese medicine analgesic suppository. The patients are 15-70 years old, wherein 58 cases of men account for 45.3%, and 70 cases of women account for 54.6%. To eliminate individual differences, the same patient was selected to use different drugs alternately every day. The analgesic selected by the treatment group is a product commonly used in the field of anorectal at present. The method comprises the following steps: mayinglong pile suppository, anal suppository and indomethacin azolone suppository; the Xue's analgesic suppository is selected as the observation group.

All cases were divided into four categories: wherein 24 cases of mixed hemorrhoids account for 18.8 percent, 15 cases of males account for 62.5 percent, and 9 cases of females account for 37.5 percent; the mixed hemorrhoids are combined with 56 cases of internal hemorrhoids, anal fissure, intestinal mucosa prolapse and proctoptosis, accounting for 43.8 percent, wherein 18 cases of men account for 32 percent, and 38 cases of women account for 67.9 percent; 13 complicated thrombotic external hemorrhoids account for 10 percent, wherein 10 male accounts for 76.9 percent, and 3 female accounts for 23 percent; 35 cases of high-level complex anal fistula account for 27.3 percent, wherein 31 cases of men account for 88.6 percent, and 4 cases of women account for 11.4 percent.

All subjects underwent surgery with sacral anesthesia. Postoperative intravenous administration of broad-spectrum antibiotics and hemostats; orally taking the traditional Chinese medicine with the efficacies of detoxifying and stopping bleeding, tonifying qi and enriching blood, strengthening spleen and stomach and the like; chinese medicines with the effects of detoxifying, detumescence, promoting blood circulation, removing blood stasis, removing necrotic tissue, promoting granulation and the like are selected for fumigation and washing for hot compress on the wound surface. One fourth of the patients were drawn at random to ensure that each group had patients of different disease species. After the operation is finished, four different suppositories are respectively placed on the internal anal tooth line by about 5 cm. The suppository which is different from the suppository in the previous day is placed after the next day after the operation, so that each person is guaranteed to have an opportunity to use four different suppositories. The three cases of mixed hemorrhoids, mixed hemorrhoids with anal fissure, rectal mucosa prolapse and complicated thrombotic external hemorrhoids have no obvious difference in the aspects of pain, bulge, edema, generation of blood stasis and the like. So they are classified into one category. High-level complex anal fistulas are one type.

The summary case is: the first category, the hemorrhoid suppository with Mucor, contains 87% of pain at III degree, 10% of pain at II degree and 3% of pain at I degree; the pain of the anal suppository accounts for 79% in III degree, 17% in II degree and 4% in I degree; the indomethacin azolidone suppository accounts for 18% of pain at the III degree, 46% of pain at the II degree, 31% of pain at the I degree and 5% of pain at the 0 degree; the Xue's Chinese medicine pain-relieving suppository has 0% of pain in III degree, 1% of pain in II degree, 65% of pain in I degree and 34% of pain in 0 degree. In all cases, pain gradually decreased with the duration of treatment. Patients who use Mayinglong hemorrhoid suppository and patients who use Xue's traditional Chinese medicine pain-relieving suppository exist when the pain is difficult to endure. In the second category, the pain of the Mayilong hemorrhoid suppository and the anal-Thai suppository at the III degree accounts for about 95 percent in the first stage, and the pain at the II degree accounts for the others; 34% of pain with indomethacin azolone suppository at the III level, 52% of pain at the II level and 14% of pain at the I level; the Xue's Chinese medicine pain plug accounts for 0% of III degree pain, 7% of II degree pain, and others are I degree pain or 0 degree pain. The medicament is used for 2-3 times per day for complex fistula patients, and 2 capsules can be used for patients with obvious pain and large weight each time. All patients who use Mayinglong hemorrhoid suppository and anal suppository or some patients who use indometacin azolone suppository use Xue's Chinese traditional medicine analgesic suppository when the pain is serious. Pain relief is typically about 20 minutes after use. With the prolonged treatment time, the dosage can be reduced to 2 times per day, 1 granule each time. Although the indomethacin azolidone suppository has a good analgesic effect, symptoms such as dizziness, incision edema and the like occur in many cases. The Xue's Chinese medicine analgesic suppository has good analgesic effect and has few cases of blood stasis and edema. After the suppository is used, the mild dizziness and the epigastric discomfort which account for about 7 percent of patients with light weight or weak constitution are mostly felt, and the mild dizziness and the epigastric discomfort disappear in about 1 hour without discovering other discomfort symptoms.

3. Observation of clinical curative effect of obstetrics: the selected cases were all patients undergoing caesarean section surgery, and the total number of cases was 105. The case criteria were selected: the patients have no mental consciousness disorder and physiological immunodeficiency, and are postoperative patients who voluntarily use Xue's Chinese medicinal analgesic suppository, and the patients are 22-36 years old. The proportion of 52 cases of the first tire accounts for 49.5 percent, 48 cases of the second tire accounts for 45.7 percent, and 5 cases of the third tire accounts for 4.8 percent.

Grading of pain according to the standards established by the world health organization. All cases were randomly divided into two groups, treatment and observation. The analgesic drug selected by the treatment group is an analgesic pump commonly used in the field (the drug is a conventional combined drug), and the traditional Chinese medicine Xue's analgesic suppository is used by the observation group.

The observations were as follows: treatment groups: 78% of pain at level III, 19% of pain at level II, and 3% of pain at level I; observation group: 0% of pain at level III, 56% of pain at level II, 35% of pain at level I and 9% of pain at level 0. The time of taking medicine for cesarean section operation is generally 3-5 days due to pain, and more than 95% of treatment groups use Schruck traditional Chinese medicine pain-relieving suppository due to pain. The onset time after the medicine is taken is about 10-20 minutes. The preparation is taken 2-3 times a day, and 1-2 granules are taken each time. After the medicine is taken, the mild dizziness feeling accounts for about 8 percent, and is mostly a parturient with light weight and poor constitution, and the mild dizziness symptom disappears about 1 to 2 hours without other uncomfortable symptoms.

4. Clinical curative effect observation of the rheumatism immunity department: the pain of the disease is hard to endure and lingering and difficult to cure. Oral analgesic drugs have severe gastrointestinal damage. 104 patients were randomly selected among this group of diseases. The selected cases are all diseases of the neuroimmune system such as rheumatism, rheumatoid diseases, ankylosing spondylitis and the like. The case criteria were selected: the medicine has no mental disturbance, no serious visceral diseases such as heart, brain, liver and kidney, and no physiological defect, and is a pain attack stage patient who voluntarily uses the Xue's Chinese medicine analgesic suppository. The age is 18-76 years, wherein 46 men account for 45% and 58 women account for 55.8%.

Grading of pain according to the standards established by the world health organization. All cases were randomly divided into two groups, treatment and observation. The analgesic selected by the treatment group is a suppository which is commonly used in the field and is similar to the Schroer Chinese medicine analgesic suppository, and comprises the following components: the indomethacin suppository, the diclofenac suppository and the oral non-steroid and glucocorticoid are combined for application. Schlemm's analgesic suppository was used in the observation group. To eliminate individual differences, the same patient was selected to use different drugs alternately every day, and other drugs were stopped during the observation period to eliminate the effect.

The results are as follows: the observation for about 1 hour after the application was: indomethacin suppository accounts for 37% of pain at level III, 54% of pain at level II and 9% of pain at level I: the diclofenac suppository accounts for 31% of III degree pain, 65% of II degree pain, 4% of I degree pain, 38% of III degree pain, 45% of II degree pain and 17% of I degree pain. And the symptoms of light-headedness, abdominal distension and pantothenic acid are different. The Xue's Chinese medicine pain-relieving suppository has 6% of pain in III degree, 15% of pain in II degree, 47% of pain in I degree and 32% of pain in 0 degree. Because the dosage of the Xue's traditional Chinese medicine analgesic suppository indometacin is small, and the effective and reasonable traditional Chinese medicine components are combined, the analgesic effect is good, the uncomfortable symptoms such as dizziness and abdominal distension are few, more importantly, the long-term effect is obviously better than that of the treatment group, more than 60 percent of patients can achieve the intermittent medication or stop the medication, and can engage in certain or normal activities.

The clinical treatment of the invention for special cases is as follows:

1. wei Yi (male) with the age of 70 years and the weight of 60kg suffers from late metastasis of lung and stomach cancer, which causes many intolerable pains in the body. During hospitalization in a certain three hospitals in province, various analgesics are used, so that the analgesic effect is increasingly poor, and the appetite and the digestion function are obviously reduced. After the Xue's traditional Chinese medicine analgesic suppository is used, the curative effect is obvious, the spirit and the appetite are obviously improved, and after the Xue's traditional Chinese medicine analgesic suppository is continuously used for more than 2 months, no special discomfort is found at present.

2. Senior one, male, 54 years old, and 75kg in weight, was treated in one of three hospitals in province due to fracture of both lower limbs. Postoperative pain-relieving pumps are used, and various pain-relieving medicines are added, so that the curative effect is poor and the pain is hard to endure. The Xue's Chinese medicine pain-relieving suppository is changed into 2 granules, and after 10 min, the pain is gradually relieved, and after 30 min, the pain is disappeared. After multiple doses since 5 pm, no pain appeared overnight. After the medicine is continuously used for 5 days, the condition of the patient is improved to 2 times a day, 1 granule is used for each time, and the patient is discharged after the patient is healed, so that discomfort such as dizziness, nausea and the like are not found.

3. Li Shi, female, 50 years old, weighing 52kg, had suffered from cervical cancer at a later stage, had transferred to the rectum, and showed bloody stool with red brown purulent stool with obvious swelling and pain. Various analgesics are used during the treatment period in a certain specialized hospital in province, and the analgesic effect is increasingly poor. After consultation, the hospital recommends transfer or returning home for nursing. Then placing Schopper's traditional Chinese medicine analgesic suppository in anus, 3 times daily, 1 granule per time, and orally taking traditional Chinese medicine with effects of invigorating spleen, promoting appetite, nourishing liver and kidney, invigorating qi, replenishing blood, softening and resolving hard mass etc. The pain basically disappears after 50 minutes of medication, and the tenesmus and the bleeding obviously improve after 2 days. All symptoms are obviously improved after more than 1 year of treatment.

4. Chen is male, 35 years old, and 100kg of body weight, and the patient will be diagnosed 2 hours after acute onset of renal calculus. It is taken into emergency department because of serious illness. After admission, the venous channel is opened, antibiotics are infused and conventional analgesics are infused through the analgesic pump. After 1 hour, the symptoms of lumbago, backache and anal pendulous distension are still not improved, and nausea, vomiting, blood pressure rise, palpitation, short breath and the like appear. 2 Xue's Chinese medicine pain-relieving suppository are placed in the anus immediately, after 10 min, the symptoms are slowly relieved, and the pain-relieving pump is removed, so that various symptoms are obviously improved or disappeared in about 30 min. The treatment of breaking the stone the next day, continue to use Xue's Chinese medicine analgesic suppository 2 times a day, 1 granule each time until the cure.

5. Tian Yi, female, 62 years old, 65kg in weight, was admitted after 5 days of 40 years of exacerbation due to ankylosing spondylitis. Because various analgesics including traditional Chinese medicines and western medicines, oral medicines and external medicines are used for many years, gastrointestinal and liver kidney functions are seriously damaged, and main pain symptoms are not good. After the treatment, Schlemm's traditional Chinese medicine pain-relieving suppository is placed in the anus for 1 granule, 2-3 times a day and 1 granule for each time, and the traditional Chinese medicine with the effects of strengthening spleen and tonifying kidney, dispelling wind and eliminating dampness, promoting blood circulation and removing blood stasis and the like is orally taken. The patient had a gradual improvement in pain after 50 minutes, and was not conscious of pain after 1 hour of inactivity. Continuing the above treatment scheme, the Xue's Chinese medicine analgesic suppository is changed into 2 times a day after 5 days, 1 granule each time. After 20 days of hospitalization, various symptoms are obviously improved, and mild daily activities can be carried out.

6. Li Shi, male, 26 years old, 60kg body weight, was treated for 3 days with swelling and pain due to perianal swelling. Perianal abscess is diagnosed. After conservative treatment, 1 XUECHE Chinese medicinal suppository is administered 2 times per day, and after 5 days, the red swelling subsides and the pain disappears.

7. Tian Yi, female, 24 years old, body weight 65kg, post partum perianal swelling pain with blood for 5 days. It is diagnosed as thrombotic external hemorrhoid, mixed hemorrhoid, anal fissure. The maintenance treatment is adopted because the postpartum can not be cured by the operation. Xue's Chinese medicine pain-relieving suppository is applied to anus 2 times a day, 1 granule each time. The pain is relieved after about 30 minutes of medication, the bloody stool is obviously reduced after two days, and the normal stool is recovered after 5 days.

8. Zhangzhi, male, 5 years old, 7 days painful perianal swelling. Perianal abscess is diagnosed. Transient conservative treatment due to young non-cooperative treatment. The treatment method comprises the following steps: xue's analgesic suppository for anal plug is 1/3 granules each time, 2 times a day. The swelling and pain of the next day is obviously improved, and the swelling and pain disappear after 5 days.

9. Zhao, male, 65 years old, stool with blood in spray form, with swollen mass coming out and recurrent attacks for more than ten years, and the physician can see the disease after 5 days of aggravation. It is diagnosed as mixed hemorrhoid and internal hemorrhoid. Conservative treatment was taken because patients had higher blood glucose and more severe anemia. The treatment method comprises the following steps: the Xue's analgesic suppository for anal plug is taken 2 times a day, 1 granule each time. After two days, the bloody stool gradually decreases, and after 7 days, the hemorrhage disappears.

Detailed Description

The present invention will be further described with reference to the following examples.

Example 1: heating 150 g of 36-type mixed fatty glyceride in a stainless steel pot until the mixed fatty glyceride is dissolved, sequentially adding 9g of corydalis tuber, 5g of divaricate saposhnikovia root, 5g of cassia twig, 8g of garden burnet root, 3g of gallnut, 5g of Chinese angelica, 6g of pseudo-ginseng and 3g of grassleaf sweelflag rhizome, continuously heating until the medicines are scorched or blackish brown, filtering out dregs of a decoction, adding 5g of borneol when the temperature of the mixed fatty glyceride solution in which the components are dissolved is reduced to 80 +/-5 ℃, stirring until the mixed fatty glyceride is dissolved, then adding 8g of indometacin powder, continuously stirring uniformly, pouring into a mold, and cooling to room temperature for solidification to obtain the Xuehi analgesic suppository.

Other examples differ from example 1 in the following table:

unit: keke (Chinese character of 'Keke')

The property specification is as follows: the Xue's analgesic suppository of the present invention is dark yellow, conical and bullet shaped, and each granule is 0.75 g.

The usage and dosage are as follows: the Xue's Chinese medicine pain-relieving suppository is removed from package and then inserted into anus to a depth of more than 2-5 cm, 1 granule is used for adult with a weight of more than 60kg, 1-3 times a day, the dosage of patients with poor constitution or children is reduced, and 2 granules can be used for severe patients for the first time.

Claims

1. The stype with the functions of diminishing inflammation, relieving pain and stopping bleeding is characterized by being prepared from the following components in parts by weight:

2. The stype with the efficacies of diminishing inflammation, relieving pain and stopping bleeding according to claim 1, which is characterized by comprising the following components in parts by weight:

3. The stype with the efficacies of diminishing inflammation, relieving pain and stopping bleeding according to claim 1, which is characterized by comprising the following components in parts by weight:

4. A method of preparing a suppository as claimed in claim 1, 2 or 3 having anti-inflammatory, analgesic and hemostatic effects, comprising the steps of:

heating and melting mixed fatty glyceride, sequentially adding rhizoma corydalis, radix Saposhnikoviae, ramulus Cinnamomi, radix Sangusorbae, Galla chinensis, radix Angelicae sinensis, Notoginseng radix and rhizoma Acori Graminei, further heating until the above components are brown or black brown, filtering to remove residue, cooling to 80 + -5 deg.C, adding Borneolum, stirring until Borneolum is melted, adding Indomethacin powder, further stirring, pouring into a mold, and cooling to room temperature.