CN105477015A - External-use traditional Chinese medicine lotion for postoperative anal fistula and preparation method thereof - Google Patents
External-use traditional Chinese medicine lotion for postoperative anal fistula and preparation method thereof Download PDFInfo
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- CN105477015A CN105477015A CN201610017323.0A CN201610017323A CN105477015A CN 105477015 A CN105477015 A CN 105477015A CN 201610017323 A CN201610017323 A CN 201610017323A CN 105477015 A CN105477015 A CN 105477015A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The invention provides an external-use traditional Chinese medicine lotion for the postoperative anal fistula. The traditional Chinese medicine lotion is prepared from, by weight, 25-35 parts of mirabilite, 15-25 parts of borax, 5-15 parts of alumen, 25-35 parts of roasted calamine and 5-15 parts of borneol. The prepared lotion is dissolved in water for fuming and washing and a hip bath, and has the effects of eliminating or relieving wound surface pain, edema, seepage, healing delaying and other symptoms of the postoperative anal fistula, resolving toxin with clearing coolness, relieving itch and diminishing swelling and achieving astringing and promoting granulation.
Description
Technical field
The present invention relates to technical field of Chinese medicine, being specifically related to a kind of for eliminating or the Chinese medicine preparation alleviating the symptoms such as anal fistula after operation wound pain, edema, sepage, healing delay and preparation method thereof.
Background technology
Chinese medicine anal fistula refers to that anal abscess becomes pus from bursting or cutting the rear tube chamber left over.Have inside and outside two mouthfuls, collar extension often has pus or excrement juice to flow out, and has streak thing under it, and internal orifice is positioned at the sick class disease of fistula that anus tooth trace portion is main manifestations; Anal fistula is common clinical, surgical operation is the method for unique healing at present, but due to the particularity of diseased region, general wound surface is comparatively large and structure is more complicated, the process of postoperative wound surface reparative regeneration is longer, and wound is easily infected, common wound pain, edema, sepage, delayed union etc., operation and complication often affect anorectal function, bring larger misery to patient.The generation of primary disease, bursts for carbuncle around anal orifice and rectal intestine and does not close up for a long time afterwards, and damp and hot residual poison end is most, hematogenous blockage; Or because of the dirty loss of spleen lung kidney three, or damage because of anal fissure and infect, cause fistulization; The primary symptom of anal fistula for suppurating, pain, pruritus, heating in various degree can be had time serious or with becoming thin, anemia, body be empty etc., and long-term chronic consumes symptom.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine for outer use for anal fistula after operation having elimination or alleviate the symptoms such as anal fistula after operation wound pain, edema, sepage, healing delay.
Another object of the present invention is to the preparation method that a kind of above-mentioned Chinese medicine preparation is provided.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is: a kind of external application Chinese medicine lotion for anal fistula after operation, described Chinese medicine preparation is prepared from by the powder raw material of following weight portion: 25 ~ 35 parts, Natrii Sulfas, Borax 15 ~ 25 parts, Alumen 5 ~ 15 parts, process Calamina 25 ~ 35 parts, Borneolum Syntheticum 5 ~ 15 parts.
Preferably, described Chinese medicine preparation is prepared from by the powder raw material of following weight portion: 25 ~ 30 parts, Natrii Sulfas, Borax 15 ~ 20 parts, and Alumen 5 ~ 10 parts processs Calamina 25 ~ 30 parts, Borneolum Syntheticum 5 ~ 10 parts.
Optimum proportioning is: in described Chinese medicine lotion, the weight portion of each component is 30 parts, Natrii Sulfas, Borax 20 parts, and Alumen 10 parts processs Calamina 30 parts, Borneolum Syntheticum 10 parts.
A preparation method for above-mentioned Chinese medicine preparation, specifically comprises the following steps:
A. each component in described Chinese medicine is ground respectively,
B. the raw material mix homogeneously of each weight portion of pulverizing is taken by proportioning.
The purposes of above-mentioned Chinese medicine preparation: medicament dissolution is washed demibain in water smoking, first smokes and washes afterwards, 2 times/day, each 15-20min, temperature 40-45 DEG C.
In Chinese medicine preparation of the present invention, each component pharmacology is as follows:
Natrii Sulfas: salty in the mouth is bitter, cold in nature, enters stomach, large intestine channel, under rushing down, softening the hard mass, heat clearing away., constipation due to dry stool, sore, carbuncle and painful swelling stagnant for excess-heat.In addition, the main contains sodium sulfate of Natrii Sulfas, still assorted have Sal, calcium sulfate, magnesium sulfate etc.Modern study thinks that Natrii Sulfas has obvious stimulation to reticuloendothelial system, its hypertrophy phenomenon and phagocytic activity being strengthened to some extent, strengthens the antiinflammatory action of body, by stimulating the neural reflex of body, regional flow's blood supply being enriched, accelerate lymphocyte to generate, have anti-inflammatory analgetic effect.Can make local vascular dilation after Natrii Sulfas external, blood flow is accelerated, and improves microcirculation, thus transfer the resistance against diseases of body, make phagocytic activity of monocyte strengthen simultaneously, accelerate absorption and the dissipation of inflammation, and it has height and oozes effect, also accelerate dissipation and the absorption of swollen tissue.
Borax: nature and flavor are sweet, salty, cool in nature.Tool heat clearing away expectorant, anticorrosion effect of detoxifying.Modern medicine surface, Borax is a weak base, and it is the same with boric acid weak bacteriostasis. all have inhibitory action to escherichia coli, bacillus pyocyaneus, anthrax bacillus, staphylococcus, Candida albicans etc., the sterilization that can be used for skin mucosa is anticorrosion.
Alumen: sour, puckery, cold, enters lung, spleen, liver, large intestine channel.External removing toxic substances parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration, dispels wind-phlegm.Dried Alumen removing dampness sore, hemostasisization is rotten.For eczema eczema, Ting discharging ear, pudendal pruritus leukorrhagia.In addition, Alumen water can make serum precipitate immediately in vitro, has the effect of strong coagulated protein, and it is hemorrhage to treat anal fistula after operation.
Process Calamina: sweet in the mouth, property are flat, enter liver, stomach warp, removing toxic substances improving acuity of vision and removing nebula, removing dampness promoting tissue regeneration and ulcer healing.For cataract, marginal blepharitis eye, ulcer being unable to heal, skin eczema.Pharmacological research shows that it has good inhibitory action to staphylococcus aureus, staphylococcus epidermidis and Streptococcus hemolyticus, can absorb the secretions of wound surface simultaneously, has anticorrosion, antiinflammatory, antipruritic and protection wound surface effect.
Borneolum Syntheticum: acrid in the mouth is bitter, cold nature, enters the heart, spleen, lung meridian, refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Can antipyretic analgesic, promote granulation tissue growth, there is the effect of bacteria growing inhibiting simultaneously.
Beneficial effect of the present invention: the normal indolence of anal fistula otch, easy recurrence, Natrii Sulfas, Alumen mass dissipating and swelling eliminating in Chinese medicine preparation provided by the invention (five disappear in vain fistula fall apart), to restrain antipruritic be monarch drug altogether, Borax refreshing and detoxicating, antiinflammatory sore are minister, assistant is with the antipruritic sore of Calamina removing dampness, with Borneolum Syntheticum heat-clearing and toxic substances removing, convergence granulation promoting.Thus medicament prepared by the present invention is conducive to promoting wound healing, prevents recurrence, prevention local scar is formed, and improves local blood circulation.Fang Zhong, with Natrii Sulfas, Borax, Alumen, process Calamina, Borneolum Syntheticum medicine carries out rational proportion, the hemorrhoid complicated by anal fistula lotion made, for the clinical symptoms of anal fistula after operation, there is effect of refreshing and detoxicating, relieving itching and eliminating swelling, convergence granulation promoting, can eliminate or alleviate the symptoms such as anal fistula after operation wound pain, edema, sepage, healing delay.
Clinical experiment
1, patient data
Choose anal fistula seton art postoperative patient 150 example of being in hospital in my section year January in January, 2013 to 2015; All cases all meet the diagnostic criteria of anal fistula in " the anal fistula clinical diagnosis and treatment guide " of Society of Surgery of China's anorectal surgical group formulation in 2004, are divided into treatment group and matched group according to random digits table, matched group 72 example, treatment group 78 example.In matched group 72 example, man 38 example, female 34 example; 21 ~ 68 years old age, average (31 ± 2) year; The course of disease 1 month to 6 years, average (2 ± 1) year.In treatment group 78 example, man 43 example, female 35 example; 16 ~ 58 years old age, average (30 ± 2) year; The course of disease 2 months to 5.5 years, average (2 ± 0.5) year.The physical data such as two groups of Genders, age, courses of disease compare, and no significant difference (P > 0.05), has comparability.
2, case inclusive criteria
Case inclusive criteria: (1) meets the diagnostic criteria of anal fistula; (2) age was at 16 ~ 68 years old; (3) all patients did not adopt fumigation-washing medicine to treat in 1 week; (4) without following situations: 1. with tuberculosis infection anal fistula, Crohn disease, carcinous anal fistula, anal eczema person; 2. anal canal, the rectum person that has occupying lesion; 3. patient is associated with other system major disease person; 4. trimester of pregnancy or age of sucking patient; (5) row operative treatment person is first; (6) voluntary participation clinical observation.
3, treatment and observational technique
Treatment group: select medicament dissolution of the present invention to wash demibain in water smoking, first smoke and wash afterwards, 2 times/day, each 15-20min, temperature 40-45 DEG C;
Matched group: use 1:5000 potassium permanganate solution, first smokes and washes afterwards, 2 times/day, each 15-20min, temperature 40-45 DEG C.
4, efficacy result
It is fixed that criterion of therapeutical effect is drawn up certainly with reference to " traditional Chinese medical science anorectum department disease Standardization of diagnosis and curative effect ", and take healing time as evaluation criterion, namely wound surface epithelium covers completely, cicatrix is solid, without false healing, observes wound surface do not fester again through 1 week, local edema pain symptom disappears, without hemorrhage for curing.
Two groups for the treatment of times compare, and the results are shown in Table 1
As shown in table 1,2 groups of patients all cure, and adopting Chinese medicine of the present invention relative to potassium permanganate, treatment time obviously shortens, thus proves that it is more better than potassium permanganate in the symptoms such as elimination or alleviation anal fistula after operation wound pain, edema, sepage, healing delay.
Analyze through Ridit, adopt Chinese medicine of the present invention elimination or alleviate in the symptoms such as anal fistula after operation wound pain, edema, sepage, healing delay with potassium permanganate matched group ratio, curative effect is significantly good.
Detailed description of the invention
Embodiment 1
1. the preparation method for the external application Chinese medicine lotion of anal fistula after operation: specifically comprise the following steps:
A. by raw material Natrii Sulfas, Borax, Alumen, process Calamina, Borneolum Syntheticum is pulverized respectively;
B. the powder raw material taking following weight portion is mixed with and forms: 25 parts, Natrii Sulfas, Borax 15 parts, and Alumen 5 parts processs Calamina 25 parts, Borneolum Syntheticum 5 parts.
Embodiment 2
1. the preparation method for the external application Chinese medicine lotion of anal fistula after operation: specifically comprise the following steps:
A. by raw material Natrii Sulfas, Borax, Alumen, process Calamina, Borneolum Syntheticum is pulverized respectively;
B. the powder raw material taking following weight portion is mixed with and forms: 35 parts, Natrii Sulfas, Borax 25 parts, and Alumen 15 parts processs Calamina 35 parts, Borneolum Syntheticum 15 parts.
Embodiment 3
1. the preparation method for the external application Chinese medicine lotion of anal fistula after operation: specifically comprise the following steps:
A. by raw material Natrii Sulfas, Borax, Alumen, process Calamina, Borneolum Syntheticum is pulverized respectively;
B. the powder raw material taking following weight portion is mixed with and forms: 30 parts, Natrii Sulfas, Borax 20 parts, and Alumen 10 parts processs Calamina 30 parts, Borneolum Syntheticum 10 parts.
Claims (4)
1. for an external application Chinese medicine lotion for anal fistula after operation, it is characterized in that: described Chinese medicine preparation is prepared from by the powder raw material of following weight portion: 25 ~ 35 parts, Natrii Sulfas, Borax 15 ~ 25 parts, Alumen 5 ~ 15 parts, process Calamina 25 ~ 35 parts, Borneolum Syntheticum 5 ~ 15 parts.
2. a kind of external application Chinese medicine lotion for anal fistula after operation as claimed in claim 1, it is characterized in that: described Chinese medicine preparation is prepared from by the powder raw material of following weight portion: 25 ~ 30 parts, Natrii Sulfas, Borax 15 ~ 20 parts, Alumen 5 ~ 10 parts, process Calamina 25 ~ 30 parts, Borneolum Syntheticum 5 ~ 10 parts.
3. a kind of external application Chinese medicine lotion for anal fistula after operation as claimed in claim 1, it is characterized in that: in described Chinese medicine lotion, the weight portion of each component is 30 parts, Natrii Sulfas, Borax 20 parts, Alumen 10 parts processs Calamina 30 parts, Borneolum Syntheticum 10 parts.
4. a preparation method for Chinese medicine lotion as claimed in claim 1, is characterized in that: specifically comprise the following steps:
Each component in described Chinese medicine is ground respectively,
The raw material mix homogeneously of each weight portion of pulverizing is taken by proportioning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610017323.0A CN105477015A (en) | 2016-01-12 | 2016-01-12 | External-use traditional Chinese medicine lotion for postoperative anal fistula and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610017323.0A CN105477015A (en) | 2016-01-12 | 2016-01-12 | External-use traditional Chinese medicine lotion for postoperative anal fistula and preparation method thereof |
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| CN105477015A true CN105477015A (en) | 2016-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610017323.0A Pending CN105477015A (en) | 2016-01-12 | 2016-01-12 | External-use traditional Chinese medicine lotion for postoperative anal fistula and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653356A (en) * | 2018-05-30 | 2018-10-16 | 安徽德睿轩科技服务有限公司 | A kind of pharmaceutical composition and its application for treating anorectal disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089498A (en) * | 1993-01-11 | 1994-07-20 | 绵竹县中医医院 | Fumigant for curing anal and intestinal disease |
| CN1493350A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese medicine compound preparation for treating piles and preparing process thereof |
-
2016
- 2016-01-12 CN CN201610017323.0A patent/CN105477015A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089498A (en) * | 1993-01-11 | 1994-07-20 | 绵竹县中医医院 | Fumigant for curing anal and intestinal disease |
| CN1493350A (en) * | 2003-09-18 | 2004-05-05 | 江苏扬子江药业集团有限公司 | Chinese medicine compound preparation for treating piles and preparing process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 崔世超、王荣: "一效膏配合痔疮散促进肛周脓肿术后创面愈合32例", 《中医外治杂志》 * |
| 颜永惠: "中药熏洗治疗肛瘘术后54例疗效观察", 《航空航天医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653356A (en) * | 2018-05-30 | 2018-10-16 | 安徽德睿轩科技服务有限公司 | A kind of pharmaceutical composition and its application for treating anorectal disease |
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Application publication date: 20160413 |
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