CN105168632A - Traditional Chinese medicinal plastics for promoting healing of wound of cesarean section and preparation method thereof - Google Patents
Traditional Chinese medicinal plastics for promoting healing of wound of cesarean section and preparation method thereof Download PDFInfo
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- CN105168632A CN105168632A CN201510698704.5A CN201510698704A CN105168632A CN 105168632 A CN105168632 A CN 105168632A CN 201510698704 A CN201510698704 A CN 201510698704A CN 105168632 A CN105168632 A CN 105168632A
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Abstract
The invention belongs to the field of traditional Chinese medicines, and discloses traditional Chinese medicinal plastics for promoting healing of a wound of the cesarean section and a preparation method thereof. The plastics are prepared from a film forming material, a penetration enhancer, a plasticizer, a pH regulator, a preservative, water and a traditional Chinese medicinal extract which is prepared from the following raw materials: agrimonia pilosa ledeb, caulis sargentodoxae, dandelion, fructus cnidii, folium artemisiae argyi, cortex albiziae, pseudo-ginseng and Japanese violet herb or roots. The plastics have the effects of promoting blood circulation to remove stasis, clearing heat, removing toxicity, diminishing swelling and relieving pains, can be used for cleaning necrotic tissues, sterilizing, diminishing inflammation, quickly improving microcirculation of tissues around a wound, accelerating local blood circulation and promoting quick growth of residual epithelial cells and tissues, has a remarkable treatment effect on skin wounds after the cesarean section, and has a 7d Class-A healing rate of 97.8 percent. Furthermore, scar is hardly reserved on the skin wound treated by the traditional Chinese medicinal plastics.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to department of obstetrics and gynecology medication, particularly relate to a kind of Chinese medicine liniment promoting Cesarean esction wound healing and preparation method thereof.
Background technology
Cesarean esction is one of mode of parturient childbirth, refers to the process of being taken out fetus by the stomach wall of surgical incision puerpera and uterus.Compared with natural labor, Cesarean esction is that one has traumatic operation, is intended to solve serious complication, difficult labour, complication etc. to reducing the M & M of mother and baby.In recent years, along with the continuous increase of pregnancy period obesity, lying-in woman advanced in years's number, make cesarean delivery rate more and more higher, but Cesarean esction is abdominal after all, there is wound infection and healing problems, Cesarean esction wound healing problem is the emphasis of postoperative care, wound healing is bad, has a strong impact on the postoperative rehabilitation of puerpera, not only increases the misery of puerpera, and ask when extending in hospital, increase the weight of financial burden.
The wound surface of operative incision is stress inflammatory reaction by otch local, Collagen, blood capillary and fibroblast proliferation, and granulation tissue grows, connective tissue reparation and re-epithelilization and reach healing.Wound healing is bad is the more common complication of cesarean postoperate, occur reason may with following factor about: the stomach fat of (1) puerpera is often more plump, in cesarean section, otch open-assembly time is longer, may oxidative decomposition be there is in the impact being subject to mechanism, make blood own transport poor plump Adipose tissue Blood supply and further obstacle occurs, there is the phenomenon of liquefaction of fat, affect wound healing; (2) immunity of puerpera decline, tissue edema and anemia etc., have impact on the blood fortune of the tissue of fat, be delayed the healing of otch; (3) part puerpera is associated with gestational diabetes, and hyperglycemia is not only beneficial to bacterial growth, and easily induce tissue edema is unfavorable for the healing of otch.The bad generation of wound healing, not only bad for the postpartum recovery of puerpera, is also the major reason that nurse-patient conflict occurs.Therefore, strengthen the process of Cesarean esction puerpera otch in puerperal very important.
For vast Cesarean esction patient, shortening wound healing time and reducing post-operative complication is the problem that they are concerned about most.But the antibiotic medical procedure of consistent use can not reach this purpose clinically at present.Cesarean postoperate application antibiotic has certain effect for prevention and therapy wound infection tool, but for promotion wound healing, reduces postoperative wound fat liquor and scleroma, reduce or eliminate cicatrix, etc. operation cause in the recent period and long term complication, not effect.The repair in trauma content of homeland pharmacy is very abundant, has the theoretical system shown unique characteristics, and have accumulated valuable clinical experience.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation promoting Cesarean esction wound healing, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
For achieving the above object, the present invention adopts following technical scheme:
Promote a Chinese medicine liniment for Cesarean esction wound healing, it is characterized in that the Chinese medicine clear paste comprising filmogen, penetration enhancer, plasticizer, pH adjusting agent, antiseptic, water and be made up of following raw material: Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae.
Because the composition of Chinese medicine clear paste is comparatively complicated, may have an effect with filmogen, or because Chinese medicine clear paste is that height oozes system, irreversible destruction is produced to the structure of liniment, therefore preferably, filmogen described above be selected from hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose, gelatin, arabic gum, sodium carboxymethyl cellulose, polyvinyl alcohol, PVP K30, sodium alginate and zein one or more, further preferably, filmogen described above is selected from sodium carboxymethyl cellulose and PVP K30.
Preferably, penetration enhancer described above is azone; Described plasticizer is glycerol, and described pH adjusting agent is triethanolamine; Described antiseptic is methyl hydroxybenzoate.
Preferably, a kind of Chinese medicine liniment promoting Cesarean esction wound healing, it is characterized in that, by weight percentage, comprise filmogen 1-15%, penetration enhancer 0.5-5%, plasticizer 1-15%, pH adjusting agent 0-4%, antiseptic 0.1-1.0%, Chinese medicine clear paste 5-50%, surplus be water.
Further preferably, a kind of Chinese medicine liniment promoting Cesarean esction wound healing, it is characterized in that, by weight percentage, comprise sodium carboxymethyl cellulose 2.0-6.0%, PVP K30 3.5-6.5%, azone 0.8-1.5%, glycerol 4-9%, methyl hydroxybenzoate 0.1-0.5%, Chinese medicine clear paste 10-20%, surplus be water, regulate pH to be 6.5-7.3 with triethanolamine.
In order to increase the synergism of effective active composition in clear paste, inventor is in conjunction with modern Chinese medicine theory of development, from raising curative effect of medication, the angle reducing side effect is set out, carry out screening to composition in Chinese medicine clear paste to extract and prescription test, optimize following technical scheme further: a kind of Chinese medicine liniment promoting Cesarean esction wound healing, it is characterized in that described Chinese medicine clear paste is made up of the raw material of following preferred weight part: Herba Agrimoniae 8-18 part, Caulis Sargentodoxae 10-30 part, Herba Taraxaci 10-30 part, Fructus Cnidii 5-15 part, Folium Artemisiae Argyi 8-18 part, Cortex Albiziae 5-15 part, Radix Notoginseng 11-21 part, Herba Violae japonicae 8-18 part.
Further preferably, promote a Chinese medicine liniment for Cesarean esction wound healing, it is characterized in that being made up of the raw material of following preferred weight part: Herba Agrimoniae 12-15 part, Caulis Sargentodoxae 15-20 part, Herba Taraxaci 18-23 part, Fructus Cnidii 10-15 part, Folium Artemisiae Argyi 13-18 part, Cortex Albiziae 8-13 part, Radix Notoginseng 13-18 part, Herba Violae japonicae 8-13 part.
Further preferably, promote a Chinese medicine liniment for Cesarean esction wound healing, it is characterized in that being made up of the raw material of following preferred weight part: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts.
Fang Zhong: Radix Notoginseng is apt to dissipating blood stasis hemostasis, and subduing swelling and relieving pain is monarch drug, has very strong blood circulation promoting and blood stasis dispelling function outward, to improve the microcirculation of wound surface surrounding tissue.Herba Taraxaci energy heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Caulis Sargentodoxae has heat-clearing and toxic substances removing, invigorates blood circulation, effect of dispelling wind for relieving itching, two medicine 5 use, heat-clearing and toxic substances removing, and mass dissipating and swelling eliminating power is strong, is ministerial drug.Fructus Cnidii has effect of dampness removing to stop itchin, Folium Artemisiae Argyi energy removing dampness to relieve itching, warm promoting blood circulation; Cortex Albiziae is kind and blood is subsided a swelling, pain relieving; Herba Violae japonicae blood stasis dispelling evacuation of pus, removing pathogenic heat from blood and toxic substance from the body; Herba Agrimoniae astringing to arrest bleeding, detumescence of healing the wounds, tool is adjuvant drug, and full side has effect of promoting blood circulation to remove blood stasis, subduing swelling and relieving pain, heat-clearing and toxic substances removing, convergence granulation promoting combined into it.
The raw materials used pharmacological property of the present invention is as follows:
Herba Agrimoniae: [nature and flavor] bitter in the mouth, puckery, property is put down.[return through] lung; Liver; Spleen channel.[function cures mainly] astringing to arrest bleeding, dysentery relieving, parasite killing.Main spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Bleeding not during menses; Impairment caused by overstrain takes off power; Carbuncle; Traumatic injury; Wound hemorrhage.
Caulis Sargentodoxae: [nature and flavor] are bitter, flat.[return through] returns large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, invigorates blood circulation, dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
Herba Taraxaci: [nature and flavor] are bitter, sweet, cold.[return through] returns liver, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Fructus Cnidii: [nature and flavor] are pungent, bitter, temperature; Slightly poisonous.[return through] returns kidney channel.[function cures mainly] warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.
Folium Artemisiae Argyi: [nature and flavor] are pungent, bitter, temperature; Slightly poisonous.[return through] returns liver,spleen,kidney warp.[function cures mainly] dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Cortex Albiziae: [nature and flavor] are sweet, flat.[return through] GUIXIN, liver, lung meridian.[function cures mainly] resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.
Radix Notoginseng: [nature and flavor] sweet, micro-hardship, temperature.[return through] returns liver, stomach warp.[function cures mainly] dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Herba Violae japonicae: [nature and flavor] bitter in the mouth; Micro-pungent; Cold in nature.[return through] liver; Spleen channel.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis dispelling evacuation of pus; Removing heat from blood liver heat removing.Main swollen ulcer drug; Acute mastitis; Acute appendicitis hematochezia; Suppurative osteomyelitis; Jaundice; Conjunctival congestion and swelling pain; Scrofula; Traumatic hemorrhage; Snakebite.
Described above a kind ofly promote that the Chinese medicine liniment of Cesarean esction wound healing is that Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae are extracted effective ingredient with proper method and make Chinese medicine clear paste, then add filmogen, penetration enhancer, plasticizer, pH adjusting agent, antiseptic etc. and make.
Preferably, a kind of Chinese medicine liniment promoting Cesarean esction wound healing, its preparation method comprises the following steps:
Get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.10 ~ 1.15, let cool, adding ethanol makes alcohol content reach 60-65% (preferably 65%), leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.10-1.15, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
The present invention is further illustrated below by way of testing.These tests comprise the safety evaluation, clinical observation on the therapeutic effect test etc. of liniment of the present invention.
One, the safety evaluation test of Chinese medicine liniment of the present invention
1. skin sensibiligen experiment
Select healthy new zealand white rabbit 12, body weight 2.5-3.0kg, male and female half and half, spinal column lateral symmetry region, back 8% sodium sulfide unhairing, unhairing district is body surface area 10% (about 150cm
2), sub-cage rearing, observes 24h, is divided into 3 groups at random, often organizes 4.1. blank group: excipient 1g/ is only coated in spinal column epilating area; 2. liniment intact skin group: be only coated in epilating area, spinal column both sides with liniment 1g/ prepared by the embodiment of the present invention 1; 3. liniment damaged skin group: be only coated in epilating area, spinal column both sides with liniment 1g/ prepared by the embodiment of the present invention 1, the making of damaged skin adopt sterilization syringe needle unhairing is sterilized skin draw " # " word with oozing of blood degree of being.Give by after reagent 24h.Wash away residue.And in 1,24,48,72h to 7d, the change of each rabbit body weight of observed and recorded every day, skin and hair, eye and mucosa and breathing, central nervous system are unified the situation of the systems such as quadruped locomotion.
Result of the test: each treated animal is all survived, coating treated animal is searched for food, body weight, depilation district skin, eyes conjunctiva and oral mucosa, and breathing, circulation, central nervous system and extremity activity are showed no obvious abnormalities.Therefore, the present composition is very little to new zealand white rabbit dermal toxicity, points out its clinical drug safety.
2. Skin Irritation Test
New zealand white rabbit 20, before administration, 24h is by rabbit spinal column both sides 8% sodium sulfide unhairing, and unhairing district is body surface area 10% (about 150cm
2), after unhairing, 24h checks that whether skin of unhairing is injured because of unhairing.Be divided into 4 groups, i.e. intact skin matched group, intact skin administration group, damaged skin matched group and damaged skin administration group, the making of damaged skin adopts sterilization syringe needle unhairing to be sterilized on skin and draws " # " word, and with skin oozing of blood for degree, the damaged degree of left and right sides skin is basically identical.1. intact skin matched group: be only coated in spinal column epilating area with liniment substrate 1g/ prepared by the embodiment of the present invention 1; 2. intact skin administration group: be only coated in spinal column epilating area with liniment 1g/ prepared by the embodiment of the present invention 1; 3. damaged skin matched group: be only coated in spinal column epilating area with liniment substrate 1g/ prepared by the embodiment of the present invention 1; 4. damaged skin administration group: be only coated in spinal column epilating area with liniment 1g/ prepared by the embodiment of the present invention 1.With except tested material observing after 24h, then smear identical tested material, continuous 3d, and after last coating l, 24,48,72h observes depilation district dermoreaction.There is erythema and edema score value in record, goes forward side by side to assassinate and swash intensity evaluation.
Result of the test: in experiment, single-dose and multiple dosing damaged skin group have 1 rabbit skin to occur slight erythema respectively, but can disappear voluntarily in 48h, other has no erythema and edema reaction.Result is by skin irritation intensity evaluation, and display said preparation contacts nonirritant to guinea pig skin.
3. skin allergy test
Cavia porcellus 30, male and female half and half, body weight 280-300g.Remove both sides, back by hair, area 3cm × 3cm with depilatory before experiment, observe after 24h and determine not damaged.Cavia porcellus after process is divided into three groups at random, often organizes 10.First group to tested material (the Chinese medicine liniment 0.2g/ of the embodiment of the present invention 1 preparation only), second group of blank (the substrate 0.2g/ of drug containing is not only), 3rd group of positive controls (1% 2,4-dinitro-chloro-benzene solution, positive excimer is 0.1%2,4-dinitrochlorobenzene), then observe evaluating skin allergic conditions respectively at 0h, 24h, 48h, 72h.
Result shows: erythema and edema do not appear in tested group and each 10 guinea pig skins of blank group, occur erythema after positive controls animal skin tested district self-excitation administration 1h, 6h is the most obvious, and 24h disappears gradually, after 72h, erythema is still visible reluctantly, and sensitization rate reaches 100%.Do not occur in 72h after tested group of guinea pig skin tested district self-excitation administration that erythema and edema are formed, compare indifference with blank group, illustrate that Chinese medicine liniment of the present invention can not cause skin allergy.
Two, the stability experiment of Chinese medicine liniment of the present invention
1. accelerated test
Get each 3 batches of Chinese medicine liniment test sample prepared by embodiment of the present invention 1-6, be placed in cillin bottle, sealing, in temperature (25 ± 2) DEG C, relative humidity (60 ± 5)) % condition under place 3 months, monthly sample 1 time, detect, compared with the result of 0 day by liniment stability high spot reviews project.
Result shows, under acceleration conditions, embodiment of the present invention 1-6 prepares Chinese medicine liniment appearance character and significant change does not occur, and stretchability is also better, other every stability inspection items do not have significant change yet, and these all show that Chinese medicine compound liniment has good stability.
2. long term test
Get each 3 batches of Chinese medicine liniment test sample prepared by embodiment of the present invention 1-9, be placed in cillin bottle, airtight, place 6 months under 4 ± 2 DEG C of conditions, respectively at the 1st, 3, sampling in June, check, compared with the result of 0 day by investigation project demand.
Long-term test results shows, embodiment of the present invention 1-9 prepares Chinese medicine liniment lucifuge under 4 ± 2 DEG C of conditions and places 6 months, and outward appearance is good, and stretchability is good, with 0 month epidemic situation comparison without significant difference.Chinese medicine liniment every high spot reviews index under long term test condition is substantially unchanged, illustrates that this reagent stability is good.
Three, clinical observation experiment
1 data and method
1.1 physical data: select my institute's 1 ~ December Cesarean esction patient 358 example in 2014,20 ~ 41 years old age, first Cesarean esction 272 example, again Cesarean esction 76 example, three Cesarean esction 10 examples.Be divided into observation group, each 179 examples of matched group at random.Observation group's first Cesarean esction 136 example (wherein: pregnancy complication person 25 example, abnormal fetal position 13 example, social factor 28 example, because of fetal distress Cesarean esction person 27 example, first stage of labor protracted active phase person 21 example, prolonged second stage of labor person 18 example in Labor Observation), Cesarean esction 38 example again, three Cesarean esction 5 examples; Matched group first Cesarean esction 136 example (wherein: pregnancy complication person 26 example, abnormal fetal position 14 example, social factor 27 example, because of fetal distress Cesarean esction person 26 example, first stage of labor protracted active phase person 23 example, prolonged second stage of labor person 19 example in Labor Observation), secondary Cesarean esction 38 example, three Cesarean esction 5 examples.Two groups of patients are at physical data comparing difference not statistically significant (P > 0.05).
1.2 Therapeutic Method: after stitching, after all operation in patients, Conventional antibiotic intravenous drip 3d is with prevention infection, matched group: conventional gauze is changed dressings; Treatment group: Chinese medicine liniment prepared by the invention process 1, is evenly coated on postoperative wound surface, covers with gauze.
1.3 observation index
1.3.1 wound healing situation: in 7d evaluation in puerperal, evaluation criterion: Wound healing by first intention, wound is without infection, hematoma and slough, and healing is good; Second class heals; Wound has the infection conditions such as redness, scleroma, pain, but does not suppurate; Third class heals, and pyogenic infection or cracking appear in Episiomy Wounds.
1.3.2 VAS point system is adopted to compare two groups of puerpera's postoperative 6h, 12h, 24h otch tranquillization pain.
1.3.3 wound check situation after puerpera full-moon, patient's number of cases of record scar, calculates cicatrix rate, patient's number of cases/case total number of persons × 100% of cicatrix rate=scar.
1.4 statistical procedures: application SPSS16.0 statistical software.Measurement data with
represent, and adopt t inspection to data, enumeration data adopts X 2 test, and P < 0.05 has statistical significance for difference.
2 results
2.1 liang of group maternal wound heal situations compare: treatment group otch Wound healing by first intention 175 example, healing rate is 97.8%, matched group Wound healing by first intention 153 example, and healing rate is 85.5%, two groups of comparing differences have statistical significance (P < 0.05), in table 1.
A table 1 liang group maternal wound heal situation compares (n)
| Group | Wound healing by first intention | Second class heals | Third class heals |
| Treatment group (n=179) | 175* | 4* | 0* |
| Matched group (n=179) | 153 | 23 | 3 |
Note: with matched group, * P < 0.05
2.2 liang of group puerpera postoperative wound rest pain VAS scoring is compared: postoperative 6h, postoperative 12h, postoperative 24h, treatment group puerpera rest pain VAS scoring all comparatively matched group reduces, and difference has statistical significance (P < 0.05), in table 2.
A table 2 liang group puerpera postoperative wound rest pain VAS scoring is compared
point
Note: with matched group, * P < 0.05.
2.3 liang of group maternal wound cicatrix rates compare: treatment group has cicatrix patient 8 example, and cicatrix rate is 4.5%, and matched group has cicatrix patient 74 example, and cicatrix rate is that 41.3%, two groups of comparing differences have statistical significance, in table 3.
A table 3 liang group maternal wound cicatrix rate compares (n)
| Group | n | Cicatrix rate/% |
| Treatment group | 179 | 4.5 |
| Matched group | 179 | 41.3％ |
Note: with matched group, * P < 0.05.
Clinical study results shows: compared with matched group, and puerpera's wound healing situation for the treatment of group is good, can effectively alleviate postoperative wound pain, and improve the aesthetic property of postoperative wound, patient satisfaction is high.
In a word, the present invention compared with prior art has following advantage: Chinese medicine liniment of the present invention has effect of blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, subduing swelling and relieving pain; Slough can be removed, bactericidal antiphlogistic, the rapid microcirculation improving wound surface surrounding tissue, speed regional flow, promote that remaining epithelial cell tissues grows fast, very remarkable for cesarian section postoperative skin trauma care effect, 7d Wound healing by first intention rate Gao Keda 97.8%, and traditional Chinese medicine composition for treating skin trauma of the present invention almost preventing from scar.In addition cesarian section postoperative skin wound is treated, without any side effects, both can not affect puerpera, also can not affect baby nursing, drastically increase the compliance for the treatment of patients, improve the quality of life of pregnant baby.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Gel prescription (weight portion): sodium carboxymethyl cellulose 2.6%, PVP K30 4.5%, azone 1.2%, glycerol 6.5%, methyl hydroxybenzoate 0.2%, Chinese medicine clear paste 13%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.12, let cool, adding ethanol makes alcohol content reach 65%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.12, obtain Chinese medicine clear paste, flowing steam sterilization 30 minutes, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.8 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 2
Gel prescription (weight portion): sodium carboxymethyl cellulose 4.5%, PVP K30 4.0%, azone 0.9%, glycerol 8%, methyl hydroxybenzoate 0.2%, Chinese medicine clear paste 15%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.14, let cool, adding ethanol makes alcohol content reach 65%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.10, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 7.0 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 3
Gel prescription (weight portion): sodium carboxymethyl cellulose 5.0%, PVP K30 3.5%, azone 1.3%, glycerol 7.5%, methyl hydroxybenzoate 0.1%, Chinese medicine clear paste 17%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.15, let cool, add ethanol make alcohol content reach 65% (, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.12, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.8 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 4
Gel prescription (weight portion): sodium carboxymethyl cellulose 5.0%, PVP K30 4.5%, azone 0.8%, glycerol 7.5%, methyl hydroxybenzoate 0.15%, Chinese medicine clear paste 15%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 15 parts, Caulis Sargentodoxae 15 parts, Herba Taraxaci 23 parts, Fructus Cnidii 15 parts, Folium Artemisiae Argyi 13 parts, Cortex Albiziae 12 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 10 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.10, let cool, adding ethanol makes alcohol content reach 63%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.13, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 5
Gel prescription (weight portion): sodium carboxymethyl cellulose 2.5%, PVP K30 3.8%, azone 1.0%, glycerol 5%, methyl hydroxybenzoate 0.1%, Chinese medicine clear paste 12%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 13 parts, Caulis Sargentodoxae 20 parts, Herba Taraxaci 25 parts, Fructus Cnidii 10 parts, Folium Artemisiae Argyi 18 parts, Cortex Albiziae 12 parts, Radix Notoginseng 18 parts, Herba Violae japonicae 8 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.12, let cool, adding ethanol makes alcohol content reach 60%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.12, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.6 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 6
Gel prescription (weight portion): sodium carboxymethyl cellulose 5.5%, PVP K30 3.5%, azone 1.2%, glycerol 5.0%, methyl hydroxybenzoate 0.1%, Chinese medicine clear paste 18%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 18 parts, Caulis Sargentodoxae 30 parts, Herba Taraxaci 20 parts, Fructus Cnidii 15 parts, Folium Artemisiae Argyi 8 parts, Cortex Albiziae 5 parts, Radix Notoginseng 20 parts, Herba Violae japonicae 10 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.15, let cool, adding ethanol makes alcohol content reach 65%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.10, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 7
Gel prescription (weight portion): hydroxypropyl methylcellulose 2.5%, gelatin 6.5%, azone 1.0%, glycerol 7.0%, methyl hydroxybenzoate 0.4%, Chinese medicine clear paste 15%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.10 ~ 1.15, let cool, adding ethanol makes alcohol content reach 60-65% (preferably 65%), leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.10-1.15, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of gelatin distilled water, putting heated and stirred in 55-70 DEG C of water-bath is a homogeneous transparent thick liquid, adds hydroxypropyl methylcellulose; When being cooled to 40-45 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
Embodiment 8
Gel prescription (weight portion): sodium carboxymethyl cellulose 2.5%, hydroxypropyl cellulose 3.5%, sodium alginate 4.0%, azone 1.2%, glycerol 5.0%, methyl hydroxybenzoate 0.2%, Chinese medicine clear paste 15%, surplus are water, regulates pH to be 6.5-7.3 with triethanolamine.
Chinese medicine clear paste forms: Herba Agrimoniae 15 parts, Caulis Sargentodoxae 20 parts, Herba Taraxaci 30 parts, Fructus Cnidii 10 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 18 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.12, let cool, adding ethanol makes alcohol content reach 65%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.14, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
After getting sodium carboxymethyl cellulose, hydroxypropyl cellulose, the abundant moistening of sodium alginate distilled water, stirring is a homogeneous transparent thick liquid, add Chinese medicine clear paste, add glycerol, methyl hydroxybenzoate, azone again, moisturizing, to recipe quantity, regulates pH to be 6.8 with triethanolamine, stir evenly, a brown maroon thickness homogenate, after low temperature sterilization, subpackage and get final product.
Embodiment 9
Gel prescription (weight portion): methylcellulose 2.0%, polyvinyl alcohol 1243.5%, azone 2.5%, glycerol 8.0%, methyl hydroxybenzoate 0.2%, Chinese medicine clear paste 15%, surplus are water,
Chinese medicine clear paste forms: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts;
Preparation method: get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-1 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.12, let cool, adding ethanol makes alcohol content reach 60%, leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.15, flowing steam sterilization 30 minutes, obtain Chinese medicine clear paste, for subsequent use,
Get methylcellulose and polyvinyl alcohol 124 adds suitable quantity of water, putting heated and stirred in 70-80 DEG C of water-bath is a homogeneous transparent thick liquid, add Chinese medicine clear paste, add glycerol, methyl hydroxybenzoate, azone again, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stir evenly, a brown maroon thickness homogenate, after low temperature sterilization, subpackage and get final product.
Claims (10)
1. promote a Chinese medicine liniment for Cesarean esction wound healing, it is characterized in that the Chinese medicine clear paste comprising filmogen, penetration enhancer, plasticizer, pH adjusting agent, antiseptic, water and be made up of following raw material: Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae.
2. Chinese medicine liniment as claimed in claim 1, it is characterized in that by weight percentage, comprise filmogen 1-15%, penetration enhancer 0.5-5%, plasticizer 1-15%, pH adjusting agent 0-4%, antiseptic 0.1-1.0%, Chinese medicine clear paste 5-50%, surplus be water.
3. Chinese medicine liniment as claimed in claim 1 or 2, is characterized in that described Chinese medicine clear paste is made up of the raw material of following preferred weight part: Herba Agrimoniae 8-18 part, Caulis Sargentodoxae 10-30 part, Herba Taraxaci 10-30 part, Fructus Cnidii 5-15 part, Folium Artemisiae Argyi 8-18 part, Cortex Albiziae 5-15 part, Radix Notoginseng 11-21 part, Herba Violae japonicae 8-18 part.
4. Chinese medicine liniment as claimed in claim 3, is characterized in that described Chinese medicine clear paste is made up of the raw material of following preferred weight part: Herba Agrimoniae 12-15 part, Caulis Sargentodoxae 15-20 part, Herba Taraxaci 18-23 part, Fructus Cnidii 10-15 part, Folium Artemisiae Argyi 13-18 part, Cortex Albiziae 8-13 part, Radix Notoginseng 13-18 part, Herba Violae japonicae 8-13 part.
5. Chinese medicine liniment as claimed in claim 4, is characterized in that described Chinese medicine clear paste is made up of the raw material of following preferred weight part: Herba Agrimoniae 12 parts, Caulis Sargentodoxae 18 parts, Herba Taraxaci 20 parts, Fructus Cnidii 12 parts, Folium Artemisiae Argyi 15 parts, Cortex Albiziae 10 parts, Radix Notoginseng 15 parts, Herba Violae japonicae 12 parts.
6. Chinese medicine liniment as claimed in claim 1 or 2, it is characterized in that described filmogen is selected from hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose, gelatin, arabic gum, sodium carboxymethyl cellulose, polyvinyl alcohol, PVP K30, sodium alginate and zein one or more.
7. Chinese medicine liniment as claimed in claim 1 or 2, is characterized in that described filmogen is selected from sodium carboxymethyl cellulose and PVP K30.
8. Chinese medicine liniment as claimed in claim 1 or 2, is characterized in that described penetration enhancer is azone; Described plasticizer is glycerol; Described antiseptic is methyl hydroxybenzoate; Described pH adjusting agent is triethanolamine.
9. Chinese medicine liniment as claimed in claim 1 or 2, it is characterized in that by weight percentage, comprise sodium carboxymethyl cellulose 2.0-6.0%, PVP K30 3.5-6.5%, azone 0.8-1.5%, glycerol 4-9%, methyl hydroxybenzoate 0.1-0.5%, Chinese medicine clear paste 10-20%, surplus be water, regulate pH to be 6.5-7.3 with triethanolamine.
10. the Chinese medicine liniment as described in claim 1-9, is characterized in that preparation method comprises the following steps:
Get Herba Agrimoniae, Caulis Sargentodoxae, Herba Taraxaci, Fructus Cnidii, Folium Artemisiae Argyi, Cortex Albiziae, Radix Notoginseng, Herba Violae japonicae, add 8 ~ 12 times amount water retting 4 ~ 6 hours, decoct 2 hours, second time adds 6-10 times amount soak by water 1.5 hours, third time adds 8 ~ 10 times amount soak by water 1 hour, gradation filters, merging filtrate to be evaporated to 60 DEG C of relative densities be the clear paste of 1.10 ~ 1.15, let cool, adding ethanol makes alcohol content reach 60-65% (preferably 65%), leave standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is 1.10-1.15, obtain Chinese medicine clear paste, for subsequent use,
After getting the abundant moistening of sodium carboxymethyl cellulose distilled water, putting heated and stirred in 85-90 DEG C of water-bath is a homogeneous transparent thick liquid, adds PVP K30; When being cooled to 50-60 DEG C, add Chinese medicine clear paste, then add glycerol, methyl hydroxybenzoate, azone, moisturizing, to recipe quantity, regulates pH to be 6.5-7.3 with triethanolamine, stirs evenly, obtain a brown maroon thickness homogenate, after low temperature sterilization, and subpackage and get final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943704A (en) * | 2016-04-29 | 2016-09-21 | 青岛市中心医院 | Sterilization disinfectant capable of promoting wound healing after abdominal operation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569696A (en) * | 2009-06-01 | 2009-11-04 | 孙爱莲 | Chinese medicament for traumatic wound |
| CN104306358A (en) * | 2014-11-06 | 2015-01-28 | 哈尔滨乾佰纳生物药业有限公司 | Itching-relieving scar-removing coating agent |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569696A (en) * | 2009-06-01 | 2009-11-04 | 孙爱莲 | Chinese medicament for traumatic wound |
| CN104306358A (en) * | 2014-11-06 | 2015-01-28 | 哈尔滨乾佰纳生物药业有限公司 | Itching-relieving scar-removing coating agent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943704A (en) * | 2016-04-29 | 2016-09-21 | 青岛市中心医院 | Sterilization disinfectant capable of promoting wound healing after abdominal operation |
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