CN108096402A - A kind of stype with good anti-inflammatory analgetic hemostasia effect and preparation method thereof - Google Patents
A kind of stype with good anti-inflammatory analgetic hemostasia effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of stypes and preparation method with good anti-inflammatory analgetic hemostasia effect, it is formulated by each component of following ratio of weight and number：Cassia twig 2~15, corydalis tuber 2~15, garden burnet 5~16, grass-leaved sweetflag 2~10, borneol 2~10, windproof 2~10, Chinese gall 1~10, Radix Angelicae Sinensis 2~12, Radix Notoginseng 2~12, Indomethacin 2~16.The present invention solve thes problems, such as single use of western medicine toxic side effect greatly and is applied alone Chinese medicine therapeutic effect poor.It highlights relieving spasm and pain, anti inflammatory detoxication, activate blood circulation and disperse blood clots, the effect of enriching blood etc. of stopping blooding, select rectal, the effect of wearing is walked in combination with drugs of causing resuscitation by administering aromatic drugs, the active ingredient of drug is transmitted to each histoorgan adjusting by channels and collaterals and moistens foster body, alleviate injury of the Western medicine to organs such as stomach and intestine, liver kidney, heart and brain, convenient drug administration, absorb fast, rapid-action, good analgesic effect, toxic side effect it is small, without additive, no dependence, safe and reliable, be a kind of preferable relieving spasm and pain, activate blood circulation and disperse blood clots, stop blooding anti-inflammatory stype.
Description
Technical field
The present invention relates to using Integrated TCM as anti-inflammatory analgetic hemostasis stype of raw material and preparation method thereof.
Background technology
The etiology and pathology of pain is not quite similar, and property and degree are different, and the injury and pain brought to patient is very big.
Become international difficult medical problem.Huge challenge is brought to numerous medical personnels.The common analgesic drug product of present medical circles
Majority is Western medicine.It can be divided into 1, non-steroidal anti-inflammatory drugs, 2, central anodyne (belonging to two class psychotropic substances), 3, narcoticness analgesic
Medicine (morphine etc.), 4, relieving spasm and pain medicine (atropine etc.), 5, antianxiety class medicine.Administration route has more：It is oral, intramuscular injection, quiet
Arteries and veins instils or pumps drop, anal orifice and rectal intestine bolt etc..These drugs have not stomach and intestine and liver kidney etc. in addition to analgesic effect is not ideal
With degree damage or have certain additive etc..In addition the existing frequently-used suppository in analgesic has：Indomethacin Suppository, Diclofenac
Bolt, indoles oxazolone bolt etc..These drug ingredients are Western medicine, analgesic effect and toxic side effect not yet be improved significantly.Chinese medicine
The analgesic drug product of preparation includes oral, externally applied drug and suppository etc..The more unobvious of analgesic effect or have no small toxic side effect and
It is additive.
The content of the invention
The present invention provides a kind of stype with good anti-inflammatory analgetic hemostasia effect, to overcome disadvantage existing in the prior art
End.
Purpose to realize the present invention, this stype with good anti-inflammatory analgetic hemostasia effect, it is characterized in that it is by following
The each component of ratio of weight and number is formulated：
Cassia twig 2~15, corydalis tuber 2~15, garden burnet 5~16, grass-leaved sweetflag 2~10, borneol 2~10, windproof 2~10, Chinese gall 1
~10, Radix Angelicae Sinensis 2~12, Radix Notoginseng 2~12, Indomethacin 2~16.
The each component preferred weight portion rate is：
Cassia twig 3~9, corydalis tuber 5~12, garden burnet 10~12, grass-leaved sweetflag 2~6, borneol 3~8, windproof 3~9, Chinese gall 2~
8, Radix Angelicae Sinensis 3~8, Radix Notoginseng 3~9, Indomethacin 5~10.
The each component optimum weight portion rate is：
Cassia twig 5, corydalis tuber 9, garden burnet 8, Chinese gall 3, grass-leaved sweetflag 3, borneol 5, Radix Angelicae Sinensis 5, windproof 5, Radix Notoginseng 6, Indomethacin 8.
The preparation method of this stype with good anti-inflammatory analgetic hemostasia effect, it is characterised in that comprise the steps of：
By mixed fatty glycerides heating dissolve after, sequentially add corydalis tuber, windproof, cassia twig, garden burnet, Chinese gall, when
Return, Radix Notoginseng and grass-leaved sweetflag, be further continued for being heated to above-mentioned each component in residue is filtered out after coke yellow or dark brown, then cool to 80
Borneol is added at ± 5 DEG C, addition Indomethacin powder after dissolving is stirred to borneol, is further continued for pouring into mold after stirring evenly, then
It is cooled to room temperature, the ratio of weight and number of the mixed fatty glycerides and foregoing each component is 3: 1~2: 1.
Each component effect of the present invention：
Cassia twig：It is pungent, sweet, warm.Return lung, spleen, the heart, bladder warp.With warming meridian, helps yang transforming qi, the analgesic of temperature sun, heating blood
Logical heart arteries and veins and other effects.Contained cassia oil can expand blood vessel, improve blood circulation and heart function, have it is calm, anticonvulsion, antitumor,
The effects that anti-inflammatory, antiallergy, there is inhibitory action to staphylococcus aureus, Escherichia coli, bacillus anthracis, influenza virus etc..
It is windproof：Pungent, sweet, tepor.Return bladder, liver, the spleen channel.With expelling wind and eliminating dampness analgesic, only convulsion dredging collateral, it is apt to loosing the interspaces of skin and muscles, leads to
Blood vessels, saturating muscles and bones and other effects.There is the effects that antipyretic, anti-inflammatory, calm, analgesia, anticonvulsion, antiallergy.
Corydalis tuber (corydalis tuber)：Acrid, bitter, warm.Return liver, spleen, the heart channel of Hang-Shaoyin have promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain and other effects.Corydalis tuber temperature
And with freely, Xin Run wanders away, the smooth blood vessels of energy, and dispersing blood stasis blood, air-dispersing is stagnant, and row, which is stopped up, to be tied, and network of promoting blood circulation relieves the pain bitterly.Not only promoting the circulation of qi but also promoting blood circulation, gas row
Blood leads to, and stops bitterly.Various pains can be stopped, play the role of significantly expanding blood vessel, reduce blood pressure, there is certain antibacterial, anti-inflammatory, anti-swollen
The effect of knurl.Modern pharmacological research confirms：May separate out 15 kinds of alkaloids in corydalis tuber, wherein Corydaline, B prime, Chou prime,
Kui prime has analgesic activity, especially the most notable with the analgesia of tetrahydropalmatine, sedation.Dehydrogenation yanhusu A prime, can increase
Coronary blood flow and Nutritional myocardium blood flow, prevent myocardial ischemia.Dehydrogenation Corydaline is subcutaneously injected, to the experimental of rat
The gastric ulcer that gastric ulcer, particularly pylorus ligation or aspirin induce has certain protective role, equal to gastric secretion and hydrochloric acid in gastric juice
There is inhibitory action.
Radix Angelicae Sinensis：Sweet, pungent, slight bitter, the thoughts of returning home, liver, the spleen channel.With blood circulation promoting and enriching, warming and activating meridian, analgesia spasmolysis and other effects, energy
It walks to keep, enter liver and can give birth to the moonization sun, nourshing blood and promoting blood circulation, walk the spleen channel energy and manage it stagnant gas and dissipate and precise and tiny enriched blood with changing gas.For key medicine of enriching blood.It can
It has a dizzy spell caused by for treating blood vessels inanition, palpitation and short breath, many illnesss such as numb pain.
Garden burnet：Bitter, acid is slightly cold, and Return liver, stomach, large intestine channel have cooling blood and hemostasis, purging intense heat and detonicating and other effects, garden burnet bitter cold
Drop, goes down coke, enters blood system, can drop cool blood, controlling of bleeding with astringents clearly, but clearly without rushing down, it is puckery without stagnant, it is the good merchantable brand of clearing away heat to stop bleeding.Body
It is outer experiments have shown that garden burnet to Escherichia coli, bacterium sonnei, proteus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa,
Comma bacillus, tubercle bacillus, diplococcus meningitidis etc. have antibacterial action.
Radix Notoginseng：Sweet, warm, slight bitter, returns liver and kidney channel, has hemostasia and dissipation blood stasis, detumescence ding-tong and other effects.Radix Notoginseng sweet and slightly bitter taste, is walked
Blood system, kind and battalion's hemostasis, blood stasis dispersing and fresh blood promoting, row is stagnant promotes blood circulation, and can stop blooding absurd, Removing Blood Stasis and train of thought lead to stasis, the new blood of life, for blood trouble
Key medicine.There is hemostasis without staying the stasis of blood.Hardship lets out the effects that stagnant row, blood-activating analgetic, temperature three-way meridian, eliminating stasis to subdue swelling simultaneously.
Chinese gall：It is sour, puckery, cold, return large intestine, kidney channel, have and restrain puckery intestines, astringent method hemostasis, detoxification sore treatment and other effects, be used for
Various mass formed by blood stasis.
Grass-leaved sweetflag：It is pungent, warm, the thoughts of returning home, liver,spleen,kidney warp, effect：Dirty, happy key, the logical mind, the clear sun of profit etc. are warded off with having one's ideas straightened out
Effect, grass-leaved sweetflag tranquilization and refreshment, smooth heart acute hearing ear, improving eyesight, dampness elimination appetizing are adjusted and stop up stagnant and Central Region.
Borneol：It is pungent, bitter, be slightly cold, the thoughts of returning home, spleen, lung channel, effect：Inducing resuscitation of having one's ideas straightened out, Xin Xiang walk to alter, and thorough thorough lower nothing is past not to be reached,
The logical happy key that is jammed.Clearing away heat to and alleviating pain, can radiate knot fiery poison, and the pain that disappears swells, goes to dislike life newly.For the good merchantable brand for analgesic of clearly having one's ideas straightened out.
Indomethacin is non-steroid anti-inflammatory drug, has anti-inflammatory, antipyretic and analgesic activity, and wherein analgesic effect is apparent.Yin
Pungent diindyl U.S. is to be got excited by the inhibition to epoxidase to reduce the synthesis of prostaglandin and prevent inflammatory tissue pain nerve
It is formed, inhibits inflammatory reaction, including inhibiting the chemotaxis from cell and the release of lysosomal enzyme etc..Indomethacin also acts on
Hypothalamus heat-regulating centers causes peripheral blood vessel to expand and perspire, increases heat dissipation, and generates antipyretic effect.
Prescription mechanism of the present invention：
1st, because Indomethacin can be by reducing the synthesis of prostaglandin and preventing inflammatory tissue during the inhibition of epoxidase
The formation of pain nerve impulsion, inhibits inflammatory reaction, including inhibiting the chemotaxis of leucocyte and release etc. of lysosomal enzyme
With good analgesic effect.So main component as this preparation.
2nd, corydalis tuber and Radix Notoginseng be in addition to having good analgesic effect, also has the stagnant works such as promote blood circulation of apparent promoting blood circulation and removing blood stasis, row
With can effectively increase coronary artery and renal blood flow amount, reduce myocardial oxygen consumption and the damage to urinary system.Corydalis tuber also has simultaneously
Anti- gastric acid secretion reduces the effect that gastric ulcer occurs.Indomethacin can not only so be reduced to cardiovascular system, urinary system
With the damage of gastrointestinal mucosa, moreover it is possible to expand the analgesic effect of the present invention.
3rd, nauseous pantothenic acid, the abdominal distension that Indomethacin triggers are mitigated to assist using the removing dampness to restore normal functioning of the stomach of grass-leaved sweetflag, stopping nausea and vomiting by lowering the adverse flow of QI
The gastrointestinal reactions such as abdominal pain, diarrhea.
4th, hematological system is easily made respectively to resist Indomethacin with garden burnet, the hemostasis of gallic astringent method and removing toxic substances and other effects
Histoorgan occur ulcer bleeding side effect, while garden burnet, gallic anti inflammatory detoxication effect intestinal mucosa can be played again it is good
Good protective effect.
5th, act on filling sering with the blood circulation promoting and enriching of Radix Angelicae Sinensis, with dredging collateral and other effects of having one's ideas straightened out of borneol realize promoting blood circulation jointly and
Arteries and veins is not empty, dredging collateral and arteries and veins is not stagnant, it is logical without pain so as to achieve the effect that.
6th, with cassia twig, grass-leaved sweetflag, Radix Angelicae Sinensis liter is clear, logical heart-yang, blood circulation promoting and enriching effect mitigate Indomethacin to heart and brain etc.
Have a dizzy spell caused by the damage of nervous system, palpitation and short breath, tinnitus insomnia etc. side effects.
7th, cassia twig and windproof except wind, calmness, anti-allergic effects etc., can alleviate influence of the Indomethacin to nervous system and
The generation of the symptoms such as the dizzy, restless of generation, orthocolosis.The cassia twig and windproof ceases wind having is promoted blood circulation, spasmolysis is deep etc. simultaneously
Effect also enhances the analgesic effect of the present invention.
8th, the effect of altering is walked with the pungent perfume (or spice) of borneol, the active ingredient of various drugs is quickly transmitted to whole body by train of thought nerve
Each histoorgan, to play due maximum efficiency.
9th, with the heat dissipation knot of borneol, detumescence pain goes to dislike raw new and garden burnet, gallic removing toxic substances hemostasis, antidiarrheal, antiulcer etc.
Effect prevents damage of the Indomethacin to intestinal mucosa.And it can effectively solve the bleeding pain of anorectal disease, extravasated blood water
Swollen and inflammation elimination.There is important role for the recovery for promoting anorectal disease.
10th, on the one hand the suppository formulation of rectal of the present invention can reduce damage of the oral drugs to gastric mucosa, separately
On the one hand the influence to medicine components effect such as hydrochloric acid in gastric juice can be avoided, it is often more important that hepato-enteric circulation can be avoided, reduce indoles U.S.
The pungent damage to liver.And mucous membrane of rectum rich blood vessel, it is fast and thorough to the absorption of drug, therefore dosage is small, toxic side effect is few,
Safely and effectively.
It is quality-high and inexpensive and public without additive in medical circles' pain field nonsteroidal analgesic drug product because of its good analgesic effect
It is considered one of optimal selection.But greatly reduce its utilization rate when more than its side effect.To improve this situation, this hair
It is bright in prescription and administration route etc. from entirety, be conceived to each histoorgan of whole body, rationally using Integrated TCM, make
Analgesic effect is more preferable, toxic side effect smaller.According to the traditional Chinese medical science " general rule pain, pain be not then obstructed " and doctor trained in Western medicine " prostatitis is plain
Lure pain " theory etc., and nonsteroidal anodyne " Indomethacin " is selected to stop for main component with reference to activating blood circulation and dispersing blood clots, subsiding a swelling
The Chinese medicinal component of pain and other effects, can not only significantly increase analgesic effect, it is often more important that can prevent or mitigate the poison of Indomethacin
Side effect is influenced caused by human body.
The present invention is to treat systemic disease as target, with " organic conception of the traditional Chinese medical science " and " general rule pain, pain be not then obstructed "
Etc. based on basic theories, and it is special in the distribution of wide model and the transmission of channels and collaterals of human body, the effect that adjusts, moisten foster body to combine channels and collaterals
Point, select have the effects that clearing and activating the channels and collaterals, it is promoting blood circulation and removing blood stasis, stop blooding enrich blood, harmonizing stomach and lowering adverse Qi, resuscitation with aromatics Chinese medicinal component and have
The present invention is made for raw material in good anti-inflammatory and analgesic effect Indomethacin.Using Integrated TCM, not only good analgesic effect, secondary
Effect is less (effect superposition side effect mutually subtracts), and there are abundant blood vessel and important channels and collaterals to be administered by anorectum position for selection,
The effect of wearing is walked in combination with drugs of causing resuscitation by administering aromatic drugs, the active ingredient of drug is transmitted to each histoorgan in the whole body to adjust by channels and collaterals
Section moistens foster body, avoids damage of the drug to stomach and intestine and liver, has convenient drug administration, absorbs fast, good analgesic effect, drug use
Measure small, toxic side effect is small, is suitble to crowd wide, it is applied widely the advantages that, be a kind of comparatively ideal there is relieving spasm and pain, promoting blood circulationization
It becomes silted up, the suppository for the effects that anti-inflammatory of stopping blooding.
The effect of stype preparation of the present invention：
1st, relieving spasm and pain, anti-inflammatory, promotion wound healing of stopping blooding.
For the wound of head, thoracic cavity, abdominal cavity and trunk four limbs, inflammation, calculus and occupying lesion expectant treatment and
Postoperative analgesia.To postoperative patient, suppository can be filled in after operation in anus, general clear-headed rear basic without pain process.
Especially to the patient of crissum operation on rectum, because of the drug containing removing toxic substances anastalsis, infection hemorrhage and oedema etc. seldom occurs no
Good reaction.
2nd, relieving spasm and pain, hemostasis promoting blood circulation, detoxify anti-inflammatory, detumescence and promoting granulation the effects that.
For the conservative of hemorrhoid, fistula sore, anal fissure, rectal prolapse, intestinal mucosa prolapsus, encysted rectum and anorectal region occupying lesion
Treatment and post-operative treatment.It ligatures or injects to alleviating internal piles simultaneously, mixed hemorrhoid shells Inner and pricks, accounted in intestinal mucosa reparation and rectum outside
Position venereal disease become resection and suture operation after and off-line phase falling inflation play the role of it is substantially reduced.It especially relieves pain, stop blooding, antiphlogistic effects are dashed forward
Go out.
3rd, relieving spasm and pain, promoting blood circulation and removing blood stasis, dehumidifying ceases wind etc..
The treatments such as nerve and rheumatic disease for four limbs and trunk, and effect protrudes.
The present invention be experienced five generation people concentrate on studies exploration and through continuously improving to be formed have comparatively ideal solution
Fully recover from an illness analgesic, activate blood circulation and disperse blood clots, the suppository for the effects that anti-inflammatory of stopping blooding.The present invention hereinafter referred to as Xue Shi traditional Chinese medical science analgesic suppository, Xue Shi of the present invention
Traditional Chinese medical science analgesic suppository has following features：
Drug used employs combined Chinese ＆ western medicine, efficiently solves single use of western medicine toxic side effect greatly and Chinese medicine is applied alone
The problem of therapeutic effect is poor.The relieving spasm and pain for being exaggerated drug, anti inflammatory detoxication are highlighted, activates blood circulation and disperses blood clots, stop blooding what is enriched blood etc.
Effect alleviates injury of the Western medicine to vitals such as stomach and intestine, liver kidney, heart and brain.With toxic side effect it is small, without it is additive, without according to
Lai Xing, safe and reliable, long action time, it is low-cost the features such as.Select rectal, have it is convenient and practical, rapid-action,
It can work within about 10 minutes or so to the analgesic of rectum and abdomen.Particularly for the patient that children and medication are inconvenient, advantage is more
It is aobvious to protrude.
Xue Shi traditional Chinese medical science analgesic suppository clinical observation on the therapeutic effect of the present invention：There is acute, chronic ache in ten hundreds of patients, in
Pivot, neuropathic pain, dig wound property, and inflammatory, each field such as cancerous swelling is curative for effect.2 months~October in 2017 respectively at certain
Orthopaedics, anorectum department, obstetrics and the rheumatism section of being immunized in Grade A hospital pain sensitivity area carry out paired observation.Stop by using different
Pain method has done comparative analysis.As a result it is as follows：
1st, Orthopedic Clinical observation of curative effect：Selected case is bone fracture postoperative patients, totally 115.Select case mark
It is accurate：Be a cup too low the disturbance of consciousness, no physiologic immunity defect, is the postoperative patient for voluntarily using Xue Shi traditional Chinese medical science analgesic suppositories.Age
At 10~75 years old, wherein male 86 accounted for 74.8%, women 29 accounts for 25.2%.To eliminate individual difference, same disease is selected
Different analgesic drug products are used alternatingly in people daily.The anodyne that treatment group selects stops for the product that present pain field generally uses
Pain pumps, and observation group selects Xue Shi traditional Chinese medical science analgesic suppositories.
Pain is divided into following 5 kinds of degree by the World Health Organization：
0 degree：Not bitterly；I degree：Mild pain, can nonuser intermittent pain；II degree：Moderate pain influences the Continuous Pain of rest, needs
Use anodyne：III degree：Severe pain, the Continuous Pain that non-medication cannot be alleviated；IV degree：Serious pain, lasting pain is with blood pressure, pulse
Deng variation.
Above-mentioned 115 cases are divided into four classes：Wherein limbs fracture 34 accounts for 29.6%, wherein male 21, accounts for
18.3%, women 13 accounts for 11.3%；Lower limb merge 52 of pelvic fracture, account for 45.2%, wherein male 42, account for
36.5%, women 10 accounts for 8.7%；Upper limb amputation patient 18 accounts for 15.7%, wherein male 16, accounts for 13.9%, women 2
Example, accounts for 1.7%；Lower limb amputation patient 11 accounts for 9.6%, wherein male 9, accounts for 7.8%, and women 2 accounts for 1.7%.
All subject's operations are all using general anaesthesia, postoperative all dead points broad-spectrum antibiotic and hemostat etc.；It is oral to have
The Chinese medicine of blood-enrich, strengthening spleen, tonifying kidney, synthetism hemostasis and other effects；Extract the patient of half respectively at random, it is ensured that each
There is the patient of different diseases in group.Operation terminates i.e. respectively using two kinds of different methods that relieve the pain.Second day after operation starts to make
With the relieve the pain method different from the day before yesterday.Wherein amputation divides one kind into, and fracture is one kind.
Gathering information is：The first kind, with analgesic pump patient's IV degree pain account for 5%, III degree pain account for 82%, II degree
Pain accounts for 13%；With Xue Shi traditional Chinese medical science analgesic suppository III degree pain account for 1%, II degree pain account for accounting for for 5%, I degree pain
57%, 0 degree of pain accounts for 37%.Above all of case is all with the extension for the treatment of time and pain gradually mitigates.With analgesic
The patient of pump exists and adds with Xue Shi traditional Chinese medical science analgesic suppositories when in great pain.Second class, with accounting for for analgesic pump IV degree pain
12%, III degree pain account for 78% or so, II degree pain account for 10%；2% is accounted for Xue Shi traditional Chinese medical science analgesic suppository III degree pain,
II degree pain accounts for 8%, and others account for 67% for I degree pain, and 0 degree of pain accounts for 23%.To patients with amputation per daily 2~3
Secondary, the big patient of the apparent weight of pain can be every time with 2.The patient of useful anodyne pump all add when pain is serious and use Xue
Family name's traditional Chinese medical science analgesic suppository.20 minutes or so pain is gradually alleviated after general use.With the extension for the treatment of time, dosage may decrease to often
Day 2 times, 1 tablet each time.With feel to have after Xue Shi traditional Chinese medical science analgesic suppositories it is slight it is dizzy, epigastric discomfort account for 7% or so, be mostly weight
Relatively light or weaker constitution patient, about 1 it is small when or so above-mentioned slight dizzy, epigastric discomfort symptom disappear, find no it
Its malaise symptoms.
2nd, anorectum department clinical observation on the therapeutic effect：Perianal is mostly the more sensitive spinal nerve area of pain.Pain is apparent, and analgesic is difficult
Degree is big.Selected case is perianal postoperative patients, totally 128.Select case standard：The consciousness that is a cup too low barrier
Hinder, no physiologic immunity defect, without important organs diseases such as serious heart and brain kidneys.It is the art for voluntarily using Xue Shi traditional Chinese medical science analgesic suppositories
Patient afterwards.Patient age 15~70 years old, wherein male 58, account for 45.3%, and women 70 accounts for 54.6%.To eliminate individual difference
It is different, select same patient that different drugs is used alternatingly daily.The anodyne that treatment group selects generally makes for present anal intestine field
Product.It is respectively：Mayinglong musk hemorrhoids suppository, Anal Thai tether and Indomethacin oxazolone bolt；Observation group selects the Xue Shi traditional Chinese medical science to stop
Pain bolt.
All cases are divided into four classes：Wherein mixed hemorrhoid 24 accounts for 18.8%, wherein male 15, accounts for 62.5%, women
9, account for 37.5%；Mixed hemorrhoid merges internal piles, anal fissure, intestinal mucosa prolapsus, encysted rectum 56, accounts for 43.8%, wherein male 18
Example, accounts for 32%, women 38 accounts for 67.9%；Complexity thrombosed external hemorrhoid 13 accounts for 10%, wherein male 10, accounts for
76.9%, women 3 accounts for 23%；High complex anal fistula 35 accounts for 27.3%, wherein male 31, accounts for 88.6%, women 4
Example, accounts for 11.4%.
All subject's operations all use sacral block.Postoperative all dead points broad-spectrum antibiotic and hemostat etc.；It is oral to have
The Chinese medicine of removing toxic substances hemostasis, blood-enrich, strengthening the spleen and stomach and other effects；It selects with removing toxicity for detumescence, the work(such as activate blood circulation and disperse blood clots, remove necrosis and promote granulation
The Chinese herbal fumigation and washing hot compress surface of a wound of effect.It extracts the patient of a quarter respectively at random, ensures there is the trouble of different diseases in each group
Person.Operation terminates to place four kinds of different suppositorys respectively in 5cm or so on tooth trace in anus.Second day after operation dressing place with
The day before yesterday different suppository, ensures that everyone has the opportunity to use four kinds of different suppositorys.Wherein mixed hemorrhoid, mixed hemorrhoid merge anus
It splits with prolapse of rectal mucosa, this three classes case of complexity thrombosed external hemorrhoid in pain, falling inflation, oedema and generation hemostasis etc. nothing
Apparent difference.So divide one kind into.High complex anal fistula is one kind.
Gathering information is：The first kind accounts for accounting for for 87%, II degree pain with Mayinglong musk hemorrhoids suppository III degree pain
10%, I degree pain account for 3%；With Anal Thai tether III degree pain account for 79%, II degree pain account for accounting for for 17%, I degree pain
4%；Indomethacin oxazolone bolt III degree pain account for 18%, II degree pain account for 46%, I degree pain account for 31%, 0 degree of pain
Account for 5%；With Xue Shi traditional Chinese medical science analgesic suppository III degree pain account for 0%, II degree pain account for 1%, I degree pain account for 65%, 0 degree
Pain accounts for 34%.Above all of case is all with the extension for the treatment of time and pain gradually mitigates.With Ma Yinglong Suppository for treatment of pile
Patient and the patient with Anal Thai tether, all exist and add with Xue Shi traditional Chinese medical science analgesic suppositories when in great pain.Second class, first stage are used
Ma Yinglong Suppository for treatment of pile and account for 95% or so with Anal Thai tether III degree pain, others are II degree pain；With Indomethacin oxazolone
The III degree pain of bolt account for 34%, II degree pain account for 52%, I degree pain account for 14%；With Xue Shi traditional Chinese medical science analgesic suppository III degree
Pain account for 0%, II degree pain account for 7%, others are I degree pain or 0 degree of pain.To complex fistula patient per daily 2~3
Secondary, the big patient of the apparent weight of pain can be every time with 2.Useful Ma Yinglong Suppository for treatment of pile and Anal Thai tether patient or part use
The patient of Indomethacin oxazolone bolt adds when pain is serious with Xue Shi traditional Chinese medical science analgesic suppositories.20 minutes or so pain is delayed after general use
Solution.With the extension for the treatment of time, dosage may decrease to 2 times a day, 1 tablet each time.Although Indomethacin oxazolone bolt analgesic effect
Preferably, but majority has the symptoms such as different degrees of dizziness and notch oedema.And Xue Shi traditional Chinese medical science analgesic suppository not only relieves pain effect
Fruit it is good and also it is few occur hemostasis oedema case.With feeling to have slight dizzy, epigastric discomfort account for after stype of the present invention
7% or so, be mostly the patient that weight is relatively light or constitution is weaker, about 1 it is small when or so above-mentioned slight dizzy, epigastric discomfort symptom
It disappears, finds no other malaise symptoms.
3rd, clinical obstetrics observation of curative effect：Selected case is the patient of Cesarean operation, totally 105.Select case
Standard：Be a cup too low the disturbance of consciousness, no physiologic immunity defect, is the postoperative patient for voluntarily using Xue Shi traditional Chinese medical science analgesic suppositories, suffers from
22~36 years old person's age.Wherein 52, the first tire accounts for 49.5%, and second fetus 48 accounts for 45.7%, and triplet 5 accounts for 4.8%.
The division of pain level, the standard formulated by the World Health Organization.All cases are divided into treatment group and sight at random
Examine two groups of group.Treatment group select anodyne be this field generally use analgesic pump (drug used be routine combination use
Medicine), observation group uses Xue Shi traditional Chinese medical science analgesic suppositories.
It is as follows to observe result：Treatment group：III degree pain account for 78%, II degree pain account for accounting for for 19%, I degree pain
3%；Observation group：III degree pain account for 0%, II degree pain account for 56%, I degree pain account for 35%, 0 degree of pain accounts for 9%.
Because the pain medication time is generally 3~5 days, adding all due to pain for treatment group more than 95% is stopped caesarean operation with the Xue Shi traditional Chinese medical science
Pain bolt.Onset time is 10~20 minutes or so after medication.Per daily 2~3 times, every time 1~2.Slight head is felt after medication
Dizzy accounts for 8% or so, is mostly the weight puerpera poor compared with light, constitution, about 1~2 it is small when or so above-mentioned slight dizziness disappear
It loses, finds no other malaise symptoms.
4th, section's clinical observation on the therapeutic effect is immunized in rheumatism：Such ache from Disease is unbearably, touching refractory.The drug of oral pain alleviating is to intestines
Stomach has more serious damage.104 patients have been randomly choosed in this kind of disease.Selected case is rheumatism, class wind
The nerve immunities systemic disease such as wet, ankylosing spondylitis.Select case standard：Be a cup too low the disturbance of consciousness, without serious heart and brain
The important organs disease such as liver kidney, no physiological defect are the panic attacks phase patient for voluntarily using Xue Shi traditional Chinese medical science analgesic suppositories.Age
18~76 years old, wherein male 46, account for 45%, women 58 accounts for 55.8%.
The division of pain level, the standard formulated by the World Health Organization.All cases are divided into treatment group and sight at random
Examine two groups of group.The anodyne that treatment group selects be this present field generally use with Xue Shi traditional Chinese medical science analgesic suppositories similar in suppository
Have：Indomethacin Suppository and Diclofenac bolt and oral nonsteroidal and glucocorticosteroidsin in combination application etc..Observation group uses Xue
Family name's traditional Chinese medical science analgesic suppository.To eliminate individual difference, select same patient that different drugs is used alternatingly daily, seen to eliminate the effects of the act
It examines experimental stage and stops using other medicines.
As a result it is as follows：The situation of observation is when medication 1 is small or so：Indomethacin Suppository III degree pain accounts for 37%, II degree pain
54%, the I degree pain that accounts for of pain is 9%：65%, the I degree that accounts for for accounting for 31%, II degree pain of Diclofenac bolt III degree pain aches
Pain accounts for 4%, the III degree pain of oral drugs account for 38%, II degree pain account for 45%, I degree pain account for 17%.And all
It is different degrees of have a dizzy spell, the malaise symptoms such as abdominal distension pantothenic acid.6%, II degree is accounted for Xue Shi traditional Chinese medical science analgesic suppository III degree pain
Pain account for 15%, I degree pain account for 47%, 0 degree of pain accounts for 32%.Due to the dosage of Xue Shi traditional Chinese medical science analgesic suppository Indomethacins
It is small, while the effective and reasonable Chinese medicinal component of compatibility, so not only good analgesic effect, and the malaise symptoms hair such as above dizzy abdominal distension
Raw is also seldom, it is often more important that long-term effect is significantly better than the treatment group, and about more than 60% patient can reach intermittent use
Or be discontinued, and certain or normal activity can be engaged in.
The present invention is as follows through clinical treatment special case：
1st, Wei, man 70 years old, weight 60kg, suffer from the transfer of lung advanced gastric cancer and cause body many places unbearably pain.Inside the province
During certain Grade A hospital hospitalization, once used a variety of anodyne, not only analgesic effect worse and worse, also result in appetite and digestion
Function is decreased obviously.After use Xue Shi traditional Chinese medical science analgesic suppositories instead after, it is evident in efficacy, spirit and appetite be obviously improved, be used continuously more than 2
After month, special discomfort is not found so far.
2nd, it is high certain, man 54 years old, weight 75kg, once fractured because of double lower limb and was treated in certain Grade A hospital inside the province.Suffered from postoperative is with stopping
Pain pumps, wherein adding a variety of analgesic drug products, curative effect is not good enough, in great pain.Use Xue Shi traditional Chinese medical science analgesic suppository 2 instead, after ten minutes
Pain gradually mitigates, and pain disappears after 30 minutes.From after being mostly used medicine at 5 points in afternoon, one night of that night does not occur pain.It is changed to afterwards every
Days 3 times, 1 tablet each time, sb.'s illness took a favorable turn after 5 days is changed to 2 times a day for continuous use, 1 tablet each time to recovery from illness discharge, do not find it is dizzy,
The discomforts such as nausea.
3rd, Lee, female, 50 years old, weight 52kg once suffered from cervical carcinoma late period, and had been transferred to rectum, shows as stool band blood and is in
Bronzing pus and blood stool, falling inflation pain are apparent.Once used a variety of anodyne during certain front three section hospital inside the province treats, analgesic effect
Fruit is worse and worse.Suggest transferring from one hospital to another or go home to raise after school's consultation of doctors.The placement Xue Shi traditional Chinese medical science analgesic suppositories in its anus afterwards, daily 3
It is secondary, 1 tablet each time, while the oral Chinese medicine with spleen benefiting and stimulating the appetite, nourishing liver and kidney, blood-enrich, softening and resolving hard mass and other effects.Medication 50
Minute after pain disappear substantially, after 2 days falling inflation bleeding be clearly better.Treatment rear each side symptom more than 1 year all has clear improvement.
4th, Chen, man, 35 years old, weight 100kg, because suffer from kidney stone acute attack 2 it is small when after go to a doctor.Because of the income that is in a bad way
Emergency department.It is admitted to hospital after making a definite diagnosis and opens venous access, input antibiotic and pass through analgesic pump and input Conventional pain medications.1 it is small when after
There are nausea and vomiting still without improvement in lumbago and rectal tenesmus, blood pressure rise, the symptoms such as palpitation and short breath.At once in its anus
Xue Shi traditional Chinese medical science analgesic suppository 2 is placed, symptom is slowly alleviated after ten minutes, removes analgesic pump, various symptoms are bright within about 30 minutes or so
It is aobvious to improve or disappear.Next day row lithotripsy in treatment continues with Xue Shi traditional Chinese medical science analgesic suppository 2 times a day, 1 tablet each time to recovery from illness.
5th, field, female, 62 years old, weight 65kg, once because being admitted to hospital after suffering from the exacerbation of more than 40 years of ankylosing spondylitis 5 days.Because for many years
Diseased once used a variety of anodyne, it is oral and external application to wait multi-medicaments including Chinese medicine and Western medicine, cause stomach and intestine and hepatic and renal function
It is badly damaged, and main pain symptom is not felt any better.It is engraved in Xue Shi traditional Chinese medical science analgesic suppository 1 built in its anus after seeing and treating patients, daily 2
~3 times, 1 tablet each time, and it is oral with strengthening spleen, tonifying kidney, except the Chinese medicine that wind-dryness is wet, activates blood circulation and disperses blood clots and other effects.Patient aches after 50 minutes
Pain gradually improve, 1 it is small when after it is inactive when felt no pain.Therapeutic scheme more than continuation, by Xue Shi traditional Chinese medical science analgesic suppositories after 5 days
It is changed to 2 times a day, 1 tablet each time.Various symptoms are obviously improved after 20 days in hospital, can be engaged in slight daily routines.
6th, Lee, man, 26 years old, weight 60kg, once because swell object congestion and swelling pain 3 days of crissum is medical.It is perianal abscess after diagnosing.
Plug Xue Shi traditional Chinese medical science analgesic suppository 1 in anus is taken after expectant treatment, 2 times a day, and notices that fasting is pungent and waits irritable foods, in
Red and swollen after 5 days to disappear, pain disappears.
7th, field, female, 24 years old, weight 65kg, postpartum crissum swell object pain and with blood 5 days.It is after diagnosing thrombosed external hemorrhoid, mixed
Close hemorrhoid, anal fissure.Holding is taken when being unable to surgical radical treatment in postpartum to treat.In filling in Xue Shi traditional Chinese medical science analgesic suppositories in anus, 2 times a day, often
Secondary 1.Medication pain relief in 30 minutes or so, band blood of defecating two days later significantly reduce, and recover normal after 5 days.
8th, Zhang, man, 5 years old, swell object pain 7 days of crissum was medical.It is perianal abscess after diagnosing.Because it is young mismatch treatment due to
Temporary expectant treatment.Therapy：Anus plug Xue Shi traditional Chinese medical science analgesic suppositories, 1/3 every time, 2 times a day.Next day swelling and pain are clearly better, and 5
Object pain that swells after it disappears.
9th, Zhao, man, 65 years old, stool band blood had swollen object abjection recurrent exerbation more than 10 years in spurting, after aggravating 5 days
It is medical.It is after diagnosing mixed hemorrhoid, internal piles.Expectant treatment is taken due to patient blood glucose is higher and anaemia is more serious.Therapy：Anus
Xue Shi traditional Chinese medical science analgesic suppositories are filled in, 2 times a day, 1 tablet each time.Stool band blood gradually decreases two days later, bleeding disappearance after 7 days.
Specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1：150 gram of 36 type mixed fatty glycerides is heated to mixed fatty glycerides in stainless-steel pan
After dissolving, corydalis tuber 9g, windproof 5g, cassia twig 5g, garden burnet 8g, Chinese gall 3g, Radix Angelicae Sinensis 5g, Radix Notoginseng 6g and grass-leaved sweetflag are sequentially added
3g is further continued for filtering out the dregs of a decoction when being heated to above-mentioned each taste medicine in coke yellow or dark brown, when the mixing dissolved with above-mentioned each component
Fatty glyceride solution temperature adds in 5g borneols when dropping to 80 ± 5 DEG C, stirring adds 8g Indomethacin powder to after dissolving, so
After be further continued for pouring into mold after stirring evenly, be then cooled to room temperature solidification after obtain Xue Shi traditional Chinese medical science analgesic suppository of the present invention.
Other embodiments difference from Example 1 see the table below：
Unit：Gram
Character specification：Xue Shi traditional Chinese medical science analgesic suppository of the present invention is in dark yellow, pyramid type, bullet-shaped, every 0.75g.
Usage and dosage：2~more than 5cm depth in anus will be filled in after Xue Shi traditional Chinese medical science analgesic suppository of the present invention removal packaging, into
People 60kg weight more than persons are with 1, daily 1~3 time, and the poor patient of constitution or children's dosage are cut down according to the circumstance, and patient with severe symptoms for the first time may be used
With 2.
Claims (4)
1. a kind of stype with good anti-inflammatory analgetic hemostasia effect, it is characterized in that it is matched somebody with somebody by each component of following ratio of weight and number
It makes：
Cassia twig 2~15, corydalis tuber 2~15, garden burnet 5~16, grass-leaved sweetflag 2~10, borneol 2~10, windproof 2~10, Chinese gall 1~
10, Radix Angelicae Sinensis 2~12, Radix Notoginseng 2~12, Indomethacin 2~16.
2. the stype according to claim 1 with good anti-inflammatory analgetic hemostasia effect, it is characterized in that each component weight
Measuring portion rate is：
Cassia twig 3~9, corydalis tuber 5~12, garden burnet 10~12, grass-leaved sweetflag 2~6, borneol 3~8, windproof 3~9, Chinese gall 2~8, when
Return 3~8, Radix Notoginseng 3~9, Indomethacin 5~10.
3. the stype according to claim 1 with good anti-inflammatory analgetic hemostasia effect, it is characterized in that each component weight
Measuring portion rate is：
Cassia twig 5, corydalis tuber 9, garden burnet 8, Chinese gall 3, grass-leaved sweetflag 3, borneol 5, Radix Angelicae Sinensis 5, windproof 5, Radix Notoginseng 6, Indomethacin 8.
4. a kind of preparation method of stype with good anti-inflammatory analgetic hemostasia effect as described in claim 1,2 or 3,
It is characterized in that comprising the steps of：
After mixed fatty glycerides heating is dissolved, corydalis tuber, windproof, cassia twig, garden burnet, Chinese gall, Radix Angelicae Sinensis, three are sequentially added
Seven and grass-leaved sweetflag, it is further continued for filtering out residue when being heated to above-mentioned each component in coke yellow or dark brown, then cools to 80 ± 5 DEG C
When add in borneol, stir to borneol after dissolving addition Indomethacin powder, be further continued for pouring into mold after stirring evenly, then be cooled to
The ratio of weight and number of room temperature, the mixed fatty glycerides and each component in claim 1 is 3: 1~2: 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115429885A (en) * | 2022-10-26 | 2022-12-06 | 江苏集萃新型药物制剂技术研究所有限公司 | Pharmaceutical composition for treating rheumatism, oral dosage form and preparation method thereof |
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| CN1403142A (en) * | 2002-10-18 | 2003-03-19 | 武汉马应龙药业集团股份有限公司 | Suppository for treating piles and other anorectal diseases and its prepn |
| CN1615986A (en) * | 2004-09-17 | 2005-05-18 | 雷志成 | Chinese-western medicine compound suppository for treating prostatic diseases |
| CN106552065A (en) * | 2016-11-17 | 2017-04-05 | 合肥久诺医药科技有限公司 | It is a kind of to treat Chinese medicine suppository of hemorrhoid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115429885A (en) * | 2022-10-26 | 2022-12-06 | 江苏集萃新型药物制剂技术研究所有限公司 | Pharmaceutical composition for treating rheumatism, oral dosage form and preparation method thereof |
| CN115429885B (en) * | 2022-10-26 | 2024-07-02 | 江苏集萃新型药物制剂技术研究所有限公司 | Pharmaceutical composition for treating rheumatism, oral dosage form and preparation method thereof |
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