CN107744549A - A kind of medicine for treating toothache and preparation method thereof - Google Patents
A kind of medicine for treating toothache and preparation method thereof Download PDFInfo
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- CN107744549A CN107744549A CN201711091120.7A CN201711091120A CN107744549A CN 107744549 A CN107744549 A CN 107744549A CN 201711091120 A CN201711091120 A CN 201711091120A CN 107744549 A CN107744549 A CN 107744549A
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- asarum
- gypsum
- rehmanniae recen
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- 239000003814 drug Substances 0.000 title claims abstract description 35
- 208000004371 toothache Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 241000758794 Asarum Species 0.000 claims abstract description 12
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 12
- 239000010440 gypsum Substances 0.000 claims abstract description 12
- 241000246500 Gentianella aspera Species 0.000 claims abstract description 11
- 229940079593 drug Drugs 0.000 claims description 14
- 239000012535 impurity Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 210000001124 body fluid Anatomy 0.000 abstract description 6
- 239000010839 body fluid Substances 0.000 abstract description 6
- 238000001816 cooling Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 230000001717 pathogenic effect Effects 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 238000010926 purge Methods 0.000 abstract description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000001431 Psychomotor Agitation Diseases 0.000 description 4
- 206010038743 Restlessness Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010044565 Tremor Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 206010039759 Scrotal swelling Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
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- 206010014599 encephalitis Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000008629 longdanxiegan Substances 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
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- 235000014347 soups Nutrition 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of medicine for treating toothache and preparation method thereof, it is prepared according to a certain weight ratio by radix rehmanniae recen, radix scrophulariae, gypsum, rough gentian, asarum, medicine of the present invention has clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire, wind-dispelling, the function of nourishing Yin and falling fire, it is quick for treating toothache, good effect, do not recur.
Description
Technical field
The present invention relates to a kind of medicine for treating toothache and preparation method thereof, belongs to the field of Chinese medicines.
Technical background
Toothache refers to tooth pain caused by a variety of causes, is one of symptom common in oral disease, it is seen that in
Carious tooth, pulpitis, periapical inflammation, tooth trauma, hypersensitive dentin, wedge-shaped defect etc..The traditional Chinese medical science then thinks toothache and diseases caused by external factors ailment said due to cold or exposure, stomach
Heated is contained, and kidney deficiency hyperactivity of fire is relevant.Because western medicine side effect is big, therefore people exist to the Chinese medicine of effectively treatment toothache
Great demand, up to now, it has not been found that the relevant report on the present invention.
The content of the invention
Repeatedly checking of the present inventor according to research and the clinical test of theory of traditional Chinese medical science, effectively treatment toothache is have found finally
Medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment toothache.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is to select radix rehmanniae recen, radix scrophulariae, gypsum, rough gentian, asarum to be combined preparation, by these medicine groups
Close and cause each efficacy of drugs to produce synergy, so as to effectively treat toothache.It is wherein because its nature and flavor from radix rehmanniae recen
It is sweet, tremble with fear, the thoughts of returning home, liver and kidney channel, have clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid, control pyreticosis polydipsia, yin asthenia generating intrinsic heat, hectic fever due to yin labor is hot, interior
Heat is quenched one's thirst, and is spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.Be from radix scrophulariae because its is bitter in taste salty, it is cool, enter lung, kidney channel, there is an enriching yin, fall fire,
Relieving restlessness, the function of removing toxic substances, pyreticosis polydipsia to be controlled, send out spot, hectic fever due to yin labor heat, night sleeps not rather, spontaneous sweating, Tianjin hinder constipation, hematemesis and epistaxis,
Abscess of throat, carbuncle swells, scrofula.It is because its property acrid-sweet flavor from gypsum, trembles with fear, enters lung, stomach, it is raw with having expelling pathogenic factors from muscles for clearing heat, relieving restlessness
The function of quenching the thirst, control pyreticosis high fever and do not move back, vexed coma, delirious speech is gone mad, thirsty and dry pharynx, and lung heat asthma is anxious, heatstroke spontaneous perspiration, stomach fire head
Bitterly, have a toothache, heat toxin, which is stopped up, contains, and spot dermexanthesis, aphthae, forges deposited myogenic sore, controls ulcer sores outside, bursts and do not withdraw, soup is burning hot
Wound.It is because its is bitter in taste from rough gentian, trembles with fear, enter liver, gallbladder channel, there is purging the liver of pathogenic fire excess fire, except the function of damp-heat in lower-JIAO, controls Liver Channel heat
It is manic to contain , Jing Epilepsy, encephalitis B, headache, hot eyes, pharyngalgia, jaundice, hot dysentery, carbuncle swells sore, scrotum swelling and pain, private parts is wet to itch.From
Asarum is because its nature and flavor is pungent, temperature, enters lung, kidney channel, has wind-dispelling, cold dispelling, water-filling, open function surreptitiously, control air-cooled headache, nasosinusitis,
Analgesic, phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism.
Embodiment
The drug dose of instant component is also that inventor show that the dosage of each component is under by largely groping to summarize
Stating all has the effect of preferable in weight range:
25-35 grams of radix rehmanniae recen, 25-35 grams of radix scrophulariae, 8-15 grams of gypsum, 8-15 grams of rough gentian, 3-5 grams of asarum.
Preferable amount is:
30 grams of radix rehmanniae recen, 30 grams of radix scrophulariae, 10 grams of gypsum, 10 grams of rough gentian, 3 grams of asarum.
The preparation method of medicine of the present invention is as follows
First, stock up
1st, radix rehmanniae recen:Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip;
2nd, radix scrophulariae:Net impurity is picked, except removing LU, cleans and runs through, cut into slices, dry;
3rd, gypsum:Miscellaneous stone is removed, soil is cleaned, is broken into fritter;
4th, rough gentian:Impurity is picked, removes residual stem, is cleaned, is run through rear segment, dry;
5th, asarum:Cleared impurity, sprayed and moistened with water, timely segment, dried.
2nd, prepare
1st, the radix rehmanniae recen cooked, radix scrophulariae, gypsum, rough gentian, asarum are put into decocting container, add 6 times of amounts of water, soak 100 points
Zhong Hou, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, first time decoction liquor is poured into appearance
In device;
2nd, the dregs of a decoction of filtering are added into 4 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor;
3rd, it decoction liquor will be mixed evenly twice, and be divided into 2 doses and take.
Radix rehmanniae recen has clearing heat and cooling blood, yin-nourishing in prescription, and the function of promoting the production of body fluid is monarch drug in a prescription;Longdanxiegan excess fire, except damp-heat in lower-JIAO;
Asarum has wind-dispelling, cold dispelling, water-filling, opens function surreptitiously, and the two is ministerial drug, and three taste medicines play clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, rushed down jointly
Liver excess fire, wind-dispelling, except the effect of damp-heat in lower-JIAO, treatment toothache effect is comprehensive, and with clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire,
It can be effected a permanent cure based on wind-dispelling, radix scrophulariae has enriching yin, and fall fire, relieving restlessness, the function of removing toxic substances is adjutant, and gypsum has expelling pathogenic factors from muscles for clearing heat, and relieving restlessness is quenched the thirst
Function to make medicine, be to take stopgap measures with remaining all medicines.
Medicine of the present invention has clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire, wind-dispelling, the function of nourishing Yin and falling fire, for treating
Toothache, short treating period, quick, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention:
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight, is divided to two groups, every group 15, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode is given for administration by gavage
Medicine, twice daily, 7 days are even served, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and medicine is without bad
Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, general information
Accept toothache out-patient totally 23 for medical treatment.
2nd, diagnostic criteria
Classical symptom is gum swelling, bradymassesis, thirsty halitosis, or when pain when stop, Spurs Severe Pain to the cold, buccal swelling
Deng.
3rd, treatment method
From above-mentioned medicament, taken to patient, decoction is contained into a moment in entrance, is then swallowed, is taken 1 dose daily, take 2 daily
Secondary, 7 days are a course for the treatment of, continuously take 1 course for the treatment of.
4th, efficacy assessment standard
It is effective:Toothache symptom disappears, and constitution recovers normal, recovery from illness;
Take a turn for the better:Patient's gum swelling, bradymassesis, the phenomenon of thirsty halitosis mitigate, and toothache symptom is clearly better, and constitution is progressively extensive
It is multiple;
It is invalid:Improvement standard person is not reached.
5th, treatment results(It see the table below)
In above-mentioned treatment, with drug therapy patient with toothache 20 of the present invention, as a result effective 16, obvious effective rate 80% takes a turn for the better 3
Example, improvement rate 15%, invalid 1, total effective rate 95%.
Claims (3)
- A kind of 1. medicine for treating toothache, it is characterised in that:It is made up of the bulk drug in following weight range:25-35 grams of radix rehmanniae recen, 25-35 grams of radix scrophulariae, 8-15 grams of gypsum, 8-15 grams of rough gentian, 3-5 grams of asarum.
- 2. medicine according to claim 1, wherein the dosage of each bulk drug is:30 grams of radix rehmanniae recen, 30 grams of radix scrophulariae, 10 grams of gypsum, 10 grams of rough gentian, 3 grams of asarum.
- 3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps:(One)Stock(1)Radix rehmanniae recen:Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip;(2)Radix scrophulariae:Net impurity is picked, except removing LU, cleans and runs through, cut into slices, dry;(3)Gypsum:Miscellaneous stone is removed, soil is cleaned, is broken into fritter;(4)Rough gentian:Impurity is picked, removes residual stem, is cleaned, is run through rear segment, dry;(5)Asarum:Cleared impurity, sprayed and moistened with water, timely segment, dried;(Two)Prepare(1)Radix rehmanniae recen after processing, radix scrophulariae, gypsum, rough gentian, asarum are put into decocting container, adds 6 times of amounts of water, soaks 100 points Zhong Hou, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, first time decoction liquor is poured into appearance In device;(2)The dregs of a decoction of filtering are added into 4 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor;(3)It decoction liquor will be mixed evenly twice, and be divided into 2 doses and take.
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CN201711091120.7A CN107744549A (en) | 2017-11-08 | 2017-11-08 | A kind of medicine for treating toothache and preparation method thereof |
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CN201711091120.7A CN107744549A (en) | 2017-11-08 | 2017-11-08 | A kind of medicine for treating toothache and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114984134A (en) * | 2022-06-09 | 2022-09-02 | 白鑫东 | Traditional Chinese medicine composition and preparation for treating diseases of tooth pain, gingival hyperplasia and gingival atrophy, preparation method and application thereof |
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2017
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114984134A (en) * | 2022-06-09 | 2022-09-02 | 白鑫东 | Traditional Chinese medicine composition and preparation for treating diseases of tooth pain, gingival hyperplasia and gingival atrophy, preparation method and application thereof |
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