CN107744549A - A kind of medicine for treating toothache and preparation method thereof - Google Patents

A kind of medicine for treating toothache and preparation method thereof Download PDF

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Publication number
CN107744549A
CN107744549A CN201711091120.7A CN201711091120A CN107744549A CN 107744549 A CN107744549 A CN 107744549A CN 201711091120 A CN201711091120 A CN 201711091120A CN 107744549 A CN107744549 A CN 107744549A
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grams
medicine
asarum
gypsum
rehmanniae recen
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赵红侠
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of medicine for treating toothache and preparation method thereof, it is prepared according to a certain weight ratio by radix rehmanniae recen, radix scrophulariae, gypsum, rough gentian, asarum, medicine of the present invention has clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire, wind-dispelling, the function of nourishing Yin and falling fire, it is quick for treating toothache, good effect, do not recur.

Description

A kind of medicine for treating toothache and preparation method thereof
Technical field
The present invention relates to a kind of medicine for treating toothache and preparation method thereof, belongs to the field of Chinese medicines.
Technical background
Toothache refers to tooth pain caused by a variety of causes, is one of symptom common in oral disease, it is seen that in Carious tooth, pulpitis, periapical inflammation, tooth trauma, hypersensitive dentin, wedge-shaped defect etc..The traditional Chinese medical science then thinks toothache and diseases caused by external factors ailment said due to cold or exposure, stomach Heated is contained, and kidney deficiency hyperactivity of fire is relevant.Because western medicine side effect is big, therefore people exist to the Chinese medicine of effectively treatment toothache Great demand, up to now, it has not been found that the relevant report on the present invention.
The content of the invention
Repeatedly checking of the present inventor according to research and the clinical test of theory of traditional Chinese medical science, effectively treatment toothache is have found finally Medicine, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment toothache.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is to select radix rehmanniae recen, radix scrophulariae, gypsum, rough gentian, asarum to be combined preparation, by these medicine groups Close and cause each efficacy of drugs to produce synergy, so as to effectively treat toothache.It is wherein because its nature and flavor from radix rehmanniae recen It is sweet, tremble with fear, the thoughts of returning home, liver and kidney channel, have clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid, control pyreticosis polydipsia, yin asthenia generating intrinsic heat, hectic fever due to yin labor is hot, interior Heat is quenched one's thirst, and is spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.Be from radix scrophulariae because its is bitter in taste salty, it is cool, enter lung, kidney channel, there is an enriching yin, fall fire, Relieving restlessness, the function of removing toxic substances, pyreticosis polydipsia to be controlled, send out spot, hectic fever due to yin labor heat, night sleeps not rather, spontaneous sweating, Tianjin hinder constipation, hematemesis and epistaxis, Abscess of throat, carbuncle swells, scrofula.It is because its property acrid-sweet flavor from gypsum, trembles with fear, enters lung, stomach, it is raw with having expelling pathogenic factors from muscles for clearing heat, relieving restlessness The function of quenching the thirst, control pyreticosis high fever and do not move back, vexed coma, delirious speech is gone mad, thirsty and dry pharynx, and lung heat asthma is anxious, heatstroke spontaneous perspiration, stomach fire head Bitterly, have a toothache, heat toxin, which is stopped up, contains, and spot dermexanthesis, aphthae, forges deposited myogenic sore, controls ulcer sores outside, bursts and do not withdraw, soup is burning hot Wound.It is because its is bitter in taste from rough gentian, trembles with fear, enter liver, gallbladder channel, there is purging the liver of pathogenic fire excess fire, except the function of damp-heat in lower-JIAO, controls Liver Channel heat It is manic to contain , Jing Epilepsy, encephalitis B, headache, hot eyes, pharyngalgia, jaundice, hot dysentery, carbuncle swells sore, scrotum swelling and pain, private parts is wet to itch.From Asarum is because its nature and flavor is pungent, temperature, enters lung, kidney channel, has wind-dispelling, cold dispelling, water-filling, open function surreptitiously, control air-cooled headache, nasosinusitis, Analgesic, phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism.
Embodiment
The drug dose of instant component is also that inventor show that the dosage of each component is under by largely groping to summarize Stating all has the effect of preferable in weight range:
25-35 grams of radix rehmanniae recen, 25-35 grams of radix scrophulariae, 8-15 grams of gypsum, 8-15 grams of rough gentian, 3-5 grams of asarum.
Preferable amount is:
30 grams of radix rehmanniae recen, 30 grams of radix scrophulariae, 10 grams of gypsum, 10 grams of rough gentian, 3 grams of asarum.
The preparation method of medicine of the present invention is as follows
First, stock up
1st, radix rehmanniae recen:Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip;
2nd, radix scrophulariae:Net impurity is picked, except removing LU, cleans and runs through, cut into slices, dry;
3rd, gypsum:Miscellaneous stone is removed, soil is cleaned, is broken into fritter;
4th, rough gentian:Impurity is picked, removes residual stem, is cleaned, is run through rear segment, dry;
5th, asarum:Cleared impurity, sprayed and moistened with water, timely segment, dried.
2nd, prepare
1st, the radix rehmanniae recen cooked, radix scrophulariae, gypsum, rough gentian, asarum are put into decocting container, add 6 times of amounts of water, soak 100 points Zhong Hou, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, first time decoction liquor is poured into appearance In device;
2nd, the dregs of a decoction of filtering are added into 4 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor;
3rd, it decoction liquor will be mixed evenly twice, and be divided into 2 doses and take.
Radix rehmanniae recen has clearing heat and cooling blood, yin-nourishing in prescription, and the function of promoting the production of body fluid is monarch drug in a prescription;Longdanxiegan excess fire, except damp-heat in lower-JIAO; Asarum has wind-dispelling, cold dispelling, water-filling, opens function surreptitiously, and the two is ministerial drug, and three taste medicines play clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, rushed down jointly Liver excess fire, wind-dispelling, except the effect of damp-heat in lower-JIAO, treatment toothache effect is comprehensive, and with clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire, It can be effected a permanent cure based on wind-dispelling, radix scrophulariae has enriching yin, and fall fire, relieving restlessness, the function of removing toxic substances is adjutant, and gypsum has expelling pathogenic factors from muscles for clearing heat, and relieving restlessness is quenched the thirst Function to make medicine, be to take stopgap measures with remaining all medicines.
Medicine of the present invention has clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, purging the liver of pathogenic fire excess fire, wind-dispelling, the function of nourishing Yin and falling fire, for treating Toothache, short treating period, quick, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention:
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight, is divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, 7 days are even served, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, general information
Accept toothache out-patient totally 23 for medical treatment.
2nd, diagnostic criteria
Classical symptom is gum swelling, bradymassesis, thirsty halitosis, or when pain when stop, Spurs Severe Pain to the cold, buccal swelling Deng.
3rd, treatment method
From above-mentioned medicament, taken to patient, decoction is contained into a moment in entrance, is then swallowed, is taken 1 dose daily, take 2 daily Secondary, 7 days are a course for the treatment of, continuously take 1 course for the treatment of.
4th, efficacy assessment standard
It is effective:Toothache symptom disappears, and constitution recovers normal, recovery from illness;
Take a turn for the better:Patient's gum swelling, bradymassesis, the phenomenon of thirsty halitosis mitigate, and toothache symptom is clearly better, and constitution is progressively extensive It is multiple;
It is invalid:Improvement standard person is not reached.
5th, treatment results(It see the table below)
In above-mentioned treatment, with drug therapy patient with toothache 20 of the present invention, as a result effective 16, obvious effective rate 80% takes a turn for the better 3 Example, improvement rate 15%, invalid 1, total effective rate 95%.

Claims (3)

  1. A kind of 1. medicine for treating toothache, it is characterised in that:It is made up of the bulk drug in following weight range:
    25-35 grams of radix rehmanniae recen, 25-35 grams of radix scrophulariae, 8-15 grams of gypsum, 8-15 grams of rough gentian, 3-5 grams of asarum.
  2. 2. medicine according to claim 1, wherein the dosage of each bulk drug is:
    30 grams of radix rehmanniae recen, 30 grams of radix scrophulariae, 10 grams of gypsum, 10 grams of rough gentian, 3 grams of asarum.
  3. 3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps:
    (One)Stock
    (1)Radix rehmanniae recen:Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip;
    (2)Radix scrophulariae:Net impurity is picked, except removing LU, cleans and runs through, cut into slices, dry;
    (3)Gypsum:Miscellaneous stone is removed, soil is cleaned, is broken into fritter;
    (4)Rough gentian:Impurity is picked, removes residual stem, is cleaned, is run through rear segment, dry;
    (5)Asarum:Cleared impurity, sprayed and moistened with water, timely segment, dried;
    (Two)Prepare
    (1)Radix rehmanniae recen after processing, radix scrophulariae, gypsum, rough gentian, asarum are put into decocting container, adds 6 times of amounts of water, soaks 100 points Zhong Hou, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, first time decoction liquor is poured into appearance In device;
    (2)The dregs of a decoction of filtering are added into 4 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor;
    (3)It decoction liquor will be mixed evenly twice, and be divided into 2 doses and take.
CN201711091120.7A 2017-11-08 2017-11-08 A kind of medicine for treating toothache and preparation method thereof Pending CN107744549A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711091120.7A CN107744549A (en) 2017-11-08 2017-11-08 A kind of medicine for treating toothache and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201711091120.7A CN107744549A (en) 2017-11-08 2017-11-08 A kind of medicine for treating toothache and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984134A (en) * 2022-06-09 2022-09-02 白鑫东 Traditional Chinese medicine composition and preparation for treating diseases of tooth pain, gingival hyperplasia and gingival atrophy, preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984134A (en) * 2022-06-09 2022-09-02 白鑫东 Traditional Chinese medicine composition and preparation for treating diseases of tooth pain, gingival hyperplasia and gingival atrophy, preparation method and application thereof

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Application publication date: 20180302

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