CN104906416B - A kind of Chinese medicine composition for treating type of hyperactivity of fire caused by deficiency of YIN purpura - Google Patents
A kind of Chinese medicine composition for treating type of hyperactivity of fire caused by deficiency of YIN purpura Download PDFInfo
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Abstract
Description
技术领域technical field
本发明属于中药领域，具体涉及一种用于治疗阴虚火旺型紫癜的中药组合物。The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating purpura of yin deficiency and hyperactivity of fire.
背景技术Background technique
紫癜(purpura)是皮肤和粘膜出血后颜色改变的总称。在西医中分为过敏性紫癜(allergic purpura)和血小板减少性紫癜(thrombocytopenic purpura)。西医认为，过敏性紫癜是由于机体对某些过敏物质发生变态反应而引起毛细血管的通透性和脆性增高，导致皮下组织、粘膜及内脏器官出血及水肿，过敏原可由药物、食物、花粉、虫咬等多种因素引起；血小板减少性紫癜是由于血小板减少引起的皮肤黏膜出现瘀点、瘀斑或内脏出血。Purpura is a general term for color changes of the skin and mucous membranes after bleeding. In western medicine, it is divided into allergic purpura (allergic purpura) and thrombocytopenic purpura (thrombocytopenic purpura). Western medicine believes that allergic purpura is due to the body's allergic reaction to certain allergic substances, which causes the permeability and fragility of capillaries to increase, resulting in bleeding and edema in subcutaneous tissue, mucous membranes, and internal organs. Allergens can be caused by drugs, food, pollen, Insect bites and other factors; Thrombocytopenic purpura is petechiae, ecchymosis or internal bleeding on the skin and mucous membranes caused by thrombocytopenia.
西医认为本病与免疫有关，治疗以抗组胺药物、皮质类固醇激素、免疫抑制剂和抗生素为主，对发病急暴的患者有较好的缓解作用，近期疗效肯定。但对于慢性反复发作患者疗效不能令人满意。尤其是激素和抗生素，长期大量地使用有一定的副作用。Western medicine believes that the disease is related to immunity, and the treatment is mainly based on antihistamines, corticosteroids, immunosuppressants and antibiotics, which have a good alleviation effect on patients with acute onset, and the short-term curative effect is positive. However, the curative effect is not satisfactory for patients with chronic recurrent attacks. Especially hormones and antibiotics, long-term use in large quantities have certain side effects.
中医把此病归入“血症”范畴。根据《中华人民共和国中医药行业标准——中医病证诊断疗效标准》（ZY／T001.1～001.9-94）本病分为风热伤络型、血热伤络型、阴虚火旺型、气不摄血型四类。阴虚火旺型紫癜的临床表现为：皮肤有青紫点或斑块，时发时止。手足烦热，颧红咽干，或午后潮红，盗汗，月经过多，伴有齿衄、鼻衄。舌红，少苔，脉细数。Traditional Chinese medicine classifies this disease into the category of "blood disease". According to the "Traditional Chinese Medicine Industry Standards of the People's Republic of China - Criteria for Diagnosis and Curative Effects of TCM Syndromes" (ZY/T001.1~001.9-94), the disease is divided into wind-heat injury collateral type, blood heat injury collateral type, yin deficiency fire hyperactivity type, Qi does not absorb four types of blood. The clinical manifestations of purpura due to yin deficiency and hyperactivity of fire are: bruised and purple spots or plaques on the skin, which appear and stop from time to time. Hot hands and feet, red cheekbones, dry throat, or afternoon flushing, night sweats, menorrhagia, accompanied by teeth bleeding and epistaxis. Red tongue, less moss, thready pulse.
发明内容Contents of the invention
本发明的目的在于提供一种用于治疗阴虚火旺型紫癜的中药组合物，具有见效快、花费低、毒副作用小、不易复发等优点。The object of the present invention is to provide a traditional Chinese medicine composition for treating yin-deficiency and fire-excessive purpura, which has the advantages of quick effect, low cost, less toxic and side effects, and less recurrence.
一种用于治疗阴虚火旺型紫癜的中药组合物，其特征在于，其主要有效成分组成为：菟丝子、玉竹、枸杞子、大黄、槐角、知母、黄柏、牡丹皮、腊里叶、紫草、仙鹤草、白芍、猪哥刺头、藕节、白茅根、煅牡蛎、合欢花、甘草。A traditional Chinese medicine composition for treating yin-deficiency and fire-excessive purpura, characterized in that its main active ingredients are: Cuscuta, Polygonatum Polygonatum, Lycium barbarum, Rhubarb, Huaijiao, Anemarrhena, Phellodendron, Cortex Moutan, Lali Ye , comfrey, agrimony, white peony root, pig brother thorn head, lotus root, imperina root, calcined oyster, acacia flower, licorice.
所述的，一种用于治疗阴虚火旺型紫癜的中药组合物，由以下重量份数的原料药制成：菟丝子18-35、玉竹18-35、枸杞子12-30、大黄10-18、槐角10-18、知母10-18、黄柏10-18、牡丹皮10-15、腊里叶10-18、紫草10-18、仙鹤草10-18、白芍10-18、猪哥刺头10-15、藕节10-15、白茅根10-15、煅牡蛎10-15、合欢花10-15、甘草8-12。Said, a traditional Chinese medicine composition for treating yin deficiency and hyperactivity of fire type purpura, made of the following raw materials in parts by weight: Cuscuta 18-35, Polygonatum 18-35, Lycium barbarum 12-30, Rhubarb 10- 18. Huaijiao 10-18, Anemarrhena 10-18, Phellodendron 10-18, Moutan bark 10-15, Lali leaves 10-18, Comfrey 10-18, Agrimony 10-18, Paeoniae Alba 10-18, 10-15 pig thorns, 10-15 lotus root joints, 10-15 Imperata rhizome, 10-15 calcined oysters, 10-15 albizia julibrissin, 8-12 licorice.
优选的，一种用于治疗阴虚火旺型紫癜的中药组合物，由以下重量份数的原料药制成：菟丝子25、玉竹25、枸杞子25、大黄15、槐角15、知母15、黄柏15、牡丹皮12、腊里叶15、紫草15、仙鹤草15、白芍15、猪哥刺头12、藕节12、白茅根12、煅牡蛎12、合欢花12、甘草10。Preferably, a traditional Chinese medicine composition for treating yin-deficiency and fire-excessive purpura is made of the following raw materials in parts by weight: Cuscuta 25, Polygonatum Polygonatum 25, Lycium barbarum 25, Rhubarb 15, Huaijiao 15, Anemarrhena 15 , Phellodendron 15, Cortex Moutan 12, Leaf 15, Comfrey 15, Agrimony 15, Paeoniae Alba 15, Zhu Ge thorn head 12, lotus root 12, Imperata 12, calcined oyster 12, Albizia julibrissin 12, licorice 10.
本发明中药组合物各组分的药理药性如下。The pharmacological properties of each component of the Chinese medicine composition of the present invention are as follows.
菟丝子：味微辛，平，为养阴通络上品。《名医别录》谓其有“养肌强阴、坚筋骨”的作用。祖国医学认为，菟丝子味辛甘，性平，入肝、肾二经。具有补肾益精、养肝明目、安胎的功效。可用于腰膝酸痛、阳痿、早泄、遗精、遗尿、尿频余沥、耳鸣、头眩眼花、视力减退、先兆流产、带下等症。本发明选用双子叶植物药旋花科植物菟丝子的种子，洗净，干燥，生用。Cuscutae: slightly pungent in taste, flat, top grade for nourishing yin and dredging collaterals. "Bielu of Famous Doctors" claims that it has the effect of "nourishing muscles, strengthening yin, strengthening muscles and bones". Traditional Chinese medicine believes that Cuscuta is pungent and sweet in taste, flat in nature, and enters the liver and kidney meridians. It has the effects of invigorating the kidney and essence, nourishing the liver and improving eyesight, and preventing miscarriage. It can be used for waist and knee pain, impotence, premature ejaculation, spermatorrhea, enuresis, frequent urination, tinnitus, dizziness, vision loss, threatened abortion, leukorrhea and other diseases. The present invention selects the seeds of the dicotyledonous plant medicine Convolvulaceae Cuscuta, washes them, dries them and uses them raw.
玉竹：为百合科植物玉竹的根茎。味甘，性平。归肺、胃经。功效主治：滋阴润肺；养胃生津。燥咳；劳嗽；热病阴液耗伤之咽干口渴；内热消渴；阴虚外感；头昏眩晕；筋脉挛痛。《广西中药志》记载：“养阴清肺润燥。治阴虚，多汗，燥咳，肺痿。”本发明选用百合科植物玉竹的根茎，生用。Polygonatum: the rhizome of Polygonatum Polygonatum. Sweet in the mouth, flat in nature. Return lung, stomach warp. Efficacy and Indications: nourishing yin and nourishing the lungs; nourishing the stomach and promoting body fluid. Dry cough; fatigue cough; febrile disease, dry throat and thirst caused by yin fluid consumption; internal heat and thirst; yin deficiency and external sensation; dizziness and dizziness; "Guangxi Traditional Chinese Medicine Records" records: "Nourishing yin, clearing the lungs and moistening dryness. Treat yin deficiency, hyperhidrosis, dry cough, and lung impotence." The present invention selects the rhizome of Polygonatum Polygonatum of Liliaceae for raw use.
枸杞子：味甘；性平。归肝、肾、肺经。可养肝、滋肾、润肺。主治：肝肾亏虚；头晕目眩；目视不清；腰膝酸软；阳痿遗精；虚劳咳嗽；消渴引饮。为滋阴补血、养精明目上品。本发明选用茄科植物枸杞的成熟果实。晒干，除去果梗。生用。Lycium barbarum: sweet in taste; flat in nature. Return liver, kidney, lung meridian. It can nourish the liver, nourish the kidney and moisten the lungs. Indications: Deficiency of the liver and kidney; dizziness; blurred vision; soreness of the waist and knees; It is the top grade for nourishing yin and blood, nourishing essence and improving eyesight. The present invention selects the mature fruit of Lycium barbarum of Solanaceae plant. Dry in the sun and remove the fruit stems. raw use.
大黄：性寒，味苦。归胃、大肠、肝、脾经。有泻下攻积、泻火解毒、活血祛瘀、清泄湿热的功效。主治：实热便秘；热结胸痞；湿热泻痢；黄疸；淋病；水肿腹满；小便不利；目赤；咽喉肿痛；口舌生疮；胃热呕吐；吐血；咯血；衄血；便血；尿血；蓄血；经闭；产后瘀滞腹痛；症瘕积聚；跌打损伤；热毒痈疡；丹毒；烫伤。本发明中选用生大黄。Rhubarb: cold in nature, bitter in taste. Return stomach, large intestine, liver, spleen channel. It has the effects of purging and attacking accumulation, purging fire and detoxification, promoting blood circulation and removing blood stasis, and clearing damp and heat. Indications: Excessive heat and constipation; hot knot in the chest; damp-heat diarrhea; jaundice; gonorrhea; edema and abdominal fullness; difficulty urinating; red eyes; sore throat; sore mouth and tongue; vomiting due to stomach heat; vomiting blood; Hematuria; blood accumulation; amenorrhea; postpartum stasis and abdominal pain; abdominal mass accumulation; bruises; pyretic carbuncle and ulcer; erysipelas; scald. Raw rhubarb is selected for use in the present invention.
槐角：寒；苦；归肝、大肠经。可清热泻火，凉血止血。用于肠热便血，痔肿出血，肝热头痛，眩晕目赤。本发明选用豆科植物槐的干燥成熟果实，洗净，干燥入药。Huaijiao: cold; bitter; return to liver, large intestine channel. Can clear away heat and purging fire, cool blood to stop bleeding. For intestinal heat with blood in the stool, hemorrhoids and hemorrhage, headache due to liver heat, dizziness and red eyes. The present invention selects the dried mature fruits of the leguminous plant Sophora japonica, washes them, and dries them for medicine.
知母：性苦、甘，寒。归肺、胃、肾经。可清热泻火，生津润燥。常用于外感热病，高热烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘。本发明选用单子叶植物百合科知母的干燥根茎，切片入药，生用。Anemarrhena: bitter, sweet, cold in nature. Return lung, stomach, kidney channel. It can clear away heat and purging fire, promote body fluid and moisten dryness. It is often used for febrile disease due to exogenous pathogenic factors, high fever and polydipsia, dry cough due to lung heat, hot flashes due to bone steaming, internal heat quenching thirst, intestinal dryness and constipation. The invention selects dry rhizomes of the monocotyledonous plant Anemarrhena liliaceae, slices them into medicine, and uses them raw.
黄柏：性味：苦；寒。归肾、膀胱、大肠经。有清热燥湿，泻火除蒸，解毒疗疮之功效。主治：湿热痢疾、泄泻、黄疸；梦遗、淋浊、带下；骨蒸劳热，盗汗；以及口舌生疮；目赤肿痛；痈疽疮毒；皮肤湿疹。常作为清热解毒药；清热燥湿药。本发明选用芸香科植物黄皮树的干燥树皮。剥取树皮后，除去粗皮，晒干。生用。Cortex Phellodendri: Nature and flavor: bitter; Cold. Return kidney, bladder, large intestine channel. It has the effects of clearing away heat and dampness, purging fire and removing steam, detoxifying and treating sores. Indications: Damp-heat dysentery, diarrhea, jaundice; nocturnal emission, stranguria, leukorrhea; bone steam, labor-heat, night sweats; and sores of the mouth and tongue; red eyes and swelling pain; carbuncle sores; skin eczema. Often used as a heat-clearing and detoxifying medicine; a heat-clearing and damp-drying medicine. The present invention selects the dry bark of Rutaceae plant Pseudomonas for use. After peeling off the bark, remove the rough bark and dry it in the sun. raw use.
牡丹皮：性寒，味苦，凉，微寒。归心、肝、肾、肺经。有清热凉血、活血散瘀的功效。主治：温热病热入血分；发斑；吐衄；热病后期热伏阴分发热；阴虚骨蒸潮热；血滞经闭；痛经；痈肿疮毒；跌扑伤痛；风湿热痹。常作为凉血药、利水药、去湿药。本发明选用毛茛科植物牡丹的干燥根皮，晒干入药。Cortex Moutan: cold in nature, bitter in taste, cool, slightly cold. GUIXIN, liver, kidney, lung meridian. It has the effects of clearing away heat and cooling blood, promoting blood circulation and removing blood stasis. Indications: febrile disease heat enters the blood system; spotting; vomiting of nosebleeds; late stage of febrile disease with heat and yin distributing fever; yin deficiency bone steam and hot flashes; blood stagnation amenorrhea; dysmenorrhea; carbuncle sores; tumbling pain; rheumatism heat paralysis. It is often used as a cooling blood medicine, diuretic medicine, and dehumidification medicine. The present invention selects the dry root bark of Ranunculaceae plant peony, and dries it as medicine.
腊里叶：性味甘、微涩、凉。有疏风、清热、凉血的功效。本发明选用大戟科欣苋菜属金边桑的叶，生用。Lali Ye: sweet in nature and flavor, slightly astringent, cool. It has the effects of dispelling wind, clearing away heat and cooling blood. The present invention selects the leaf of Phnom Penh mulberry of Euphorbiaceae Amaranthus genus for raw use.
紫草：性寒，味甘、咸。归经：归心、肝经。功能 主治凉血，活血，解毒透疹。用于血热毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤。清热凉血，用于麻疹，热病癍疹，湿疹，尿血，血淋，血痢，疮疡，丹毒，烧伤，热结便秘。常作为止血药、凉血药、清热解毒药。本发明选用硬紫草。Comfrey: cold in nature, sweet and salty in taste. Guixin, Liver Channel. Function Indications for cooling blood, promoting blood circulation, detoxification and rash. It is used for blood-heat toxin, macule purple and black, impermeable measles, sores, eczema, water and fire burns. Clearing away heat and cooling blood, used for measles, febrile rash, eczema, hematuria, bloody stranguria, bloody dysentery, sores, erysipelas, burns, heat knots and constipation. It is often used as a hemostatic drug, a cooling blood drug, and a heat-clearing and detoxifying drug. The present invention selects hard comfrey for use.
仙鹤草：苦，凉，味辛、涩，性偏温，入肺、肝、脾三经，可清热凉血止血，能生真阴之虚。此草止血和血，又能补益收敛止血，其性能平不偏，故寒性、热性出血均可应用，有补脾益气的功效，为强壮性收敛止血剂。仙鹤草含仙鹤草素，它能使凝血时间缩短，血小板增加，兼有强心作用。本发明选用仙鹤草全草洗净，晒干，切段，生用。Agrimony: bitter, cool, pungent, astringent, warm in nature, enters the lung, liver, and spleen meridians, can clear away heat, cool blood and stop bleeding, and can produce deficiency of true yin. This herb can stop bleeding and hemorrhage, and can also benefit and astringe to stop bleeding. Its performance is flat and unbiased, so it can be used for both cold and hot bleeding. Agrimony contains agrimonin, which can shorten the coagulation time, increase platelets, and have a cardiotonic effect. The present invention selects Agrimony whole herb to wash, dry in the sun, cut into sections, and use raw.
白芍：性凉，味苦酸，微寒，具有补血柔肝、平肝止痛、敛阴收汗等功效。适用于阴虚发热、月经不调、胸腹胁肋疼痛、四肢挛急，泻痢腹痛、自汗盗汗、崩漏、带下等症。白芍中含有芍药甙有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。白芍煎剂能抑制痢疾杆菌、肺炎链球菌、大肠杆菌、伤寒杆菌、溶血性链球菌、绿脓杆菌等，在本发明中采用生白芍。Radix Paeoniae Alba: Cool in nature, bitter and sour in taste, slightly cold, has the effects of nourishing blood and softening the liver, calming the liver and relieving pain, astringing yin and sweating. It is suitable for yin deficiency and fever, irregular menstruation, pain in the chest, abdomen and hypochondriac, urgency in the limbs, diarrhea and abdominal pain, spontaneous sweating, metrorrhagia, and leukorrhea. Paeoniflorin contained in white peony has antibacterial, antipyretic, anti-inflammatory, increased coronary artery flow, improved myocardial nutritional blood flow, dilated blood vessels, against acute myocardial ischemia, inhibited platelet aggregation, sedative, analgesic, antispasmodic, anti-ulcer, Regulates blood sugar. Paeoniae Alba decoction can inhibit Shigella, Streptococcus pneumoniae, Escherichia coli, Bacillus typhoid, hemolytic streptococcus, Pseudomonas aeruginosa, etc. Raw Paeoniae Alba is used in the present invention.
猪哥刺头：性凉、味甘苦。有凉血止血、行瘀消肿的功用。主治：衄血、咯血、吐血、尿血、功能性子宫出血、产后出血、肝炎、肾炎、乳腺炎、跌打损伤；外用治外伤出血及痈疖等。本发明选用猪哥刺头地上全草入药。Brother Zhu thorn head: cool in nature, sweet and bitter in taste. It has the functions of cooling blood to stop bleeding, promoting blood stasis and reducing swelling. Indications: epistaxis, hemoptysis, hematemesis, hematuria, dysfunctional uterine bleeding, postpartum hemorrhage, hepatitis, nephritis, mastitis, bruises; external use to treat traumatic bleeding and carbuncle furuncle, etc. The present invention selects the whole herb on the ground of Zhuge thorn for use as medicine.
藕节：为藕连接部分，性平、味甘涩。含天门冬素、鞣质等，具有较高的药用价值，药用可以缩短出血时间，有止血散淤之效，治咳血、吐血、尿血、便血、子宫出血等。本发明选用睡莲科植物莲的肥大根茎。除去须根，晒干，生用。Lotus root joint: It is the connecting part of lotus root, with flat nature and sweet and astringent taste. Contains asparagine, tannins, etc., and has high medicinal value. Medicinal use can shorten the bleeding time, have the effect of stopping bleeding and dispersing stasis, and can cure hemoptysis, vomiting, hematuria, hematochezia, uterine bleeding, etc. The present invention selects the hypertrophic rhizome of Nymphaeaceae plant lotus for use. Remove fibrous roots, dry in the sun, and use raw.
白茅根：性寒、味甘；归心、肺、胃、膀胱经；性缓入血，降而有升，具有凉血止血，清热生津，利尿通淋的功效。主治血热吐血，衄血咯血，尿血，崩漏，紫癜，热病烦渴，胃热呕逆，肺热喘咳，小便淋沥涩痛，水肿，黄疸。本发明选用禾本科植物白茅的根茎，洗净，晒干。Rhizoma Imperatae: cold in nature, sweet in taste; Guixin, lung, stomach, and bladder meridians; in nature, it enters the blood slowly, descends and rises, has the effects of cooling blood to stop bleeding, clearing away heat and promoting body fluid, diuresis and relieving stranguria. Indications for hematemesis due to blood heat, epistaxis hemoptysis, hematuria, metrorrhagia, purpura, pyretic disease with polydipsia, stomach heat and vomiting, lung heat and wheezing and coughing, urination, phlegm and pain, edema, jaundice. The present invention selects the rhizome of Gramineae Imperatae, washes it, and dries it in the sun.
煅牡蛎：有收敛固涩，制酸止痛，重镇安神，软坚散结的功效。本发明按照《中国药典》1995年版对牡蛎的炮制规定：“取净牡蛎，照明煅法煅至酥脆”。Calcined oyster: It has the effects of astringent and astringent, antacid and pain relief, calming the nerves, softening firmness and resolving stagnation. The present invention is according to the 1995 edition of "Chinese Pharmacopoeia" to the processing regulation of oyster: "Take clean oysters, calcining them until they are crisp".
合欢花：性味甘，平，有舒郁、理气、安神、活络、养血、滋阴肾、清心明目的功效。本发明选用南蛇藤科合欢的花入药。Albizia Julibrissin: Sweet in nature and flavor, flat, has the effects of soothing depression, regulating qi, calming the nerves, activating collaterals, nourishing blood, nourishing yin and kidney, clearing heart and improving eyesight. The present invention selects the flower of Albizia juliensis of S. chinensis for use as medicine.
甘草：味甘甜，性平和，入心、脾、肺、胃四经。生用偏凉，可泻火解毒、缓急止痛。甘草还善于调和药性，解百药之毒。本发明中用生甘草。Licorice: sweet in taste, mild in nature, enters the four meridians of the heart, spleen, lung and stomach. Raw and cold, it can relieve fire and detoxify, relieve spasm and relieve pain. Licorice is also good at reconciling the properties of medicines and resolving the poison of hundreds of medicines. Raw licorice is used in the present invention.
中医认为，阴虚火旺型紫癜的基本病因病机为：本型病位在肝和肾，肝藏血，血养肝，肾藏精，精血互生，肝肾阴虚，可生内热，血随火动而溢出于脉络外，可见各种出血表现，月经过多、齿衄、鼻衄等，均为火旺之象。手足心热、盗汗、口干、便干，舌红绛少苔或光苔，脉细数或弦细数，均为阴虚内热之象。Traditional Chinese medicine believes that the basic etiology and pathogenesis of yin-deficiency and fire-excessive purpura are as follows: this type of disease is located in the liver and kidney, the liver stores blood, the blood nourishes the liver, the kidney stores essence, and the essence and blood alternate. With the fire, it overflows outside the veins, and various bleeding manifestations can be seen, such as menorrhagia, teeth bleeding, epistaxis, etc., are all signs of excessive fire. Hot palms, feet, and palms, night sweats, dry mouth, dry stool, red tongue with little or light coating, thready or thready pulse are signs of yin deficiency and internal heat.
本发明中药组合物以“滋阴清热、凉血止血”为技术方案。其中菟丝子、玉竹、枸杞子滋阴润肺补肾养肝，共为君药；大黄、槐角清热泻火，知母、黄柏、牡丹皮等以降火坚阴，共为臣药；腊里叶、紫草清热凉血，仙鹤草收敛止血，白芍酸敛收涩亦可敛阴补血、平肝柔肝，猪哥刺头、藕节止血、散瘀、消肿，白茅根清热利尿，煅牡蛎收敛固涩，合欢花理气、安神、活络，共为佐药；甘草调和药性，解百药之毒，共为使药。The traditional Chinese medicine composition of the present invention takes "nourishing yin and clearing away heat, cooling blood to stop bleeding" as the technical scheme. Among them, Cuscuta, Polygonatum Polygonatum, and Lycium barbarum nourish yin, nourish the lungs, nourish the kidneys and nourish the liver, and they are the monarch drugs; rhubarb and Huaijiao clear away heat and relieve fire, Anemarrhena, Cortex Phellodendri, Cortex Moutan, etc. are used to reduce fire and strengthen yin, and they are ministerial drugs; , Zicao clears heat and cools blood, Agrimony astringent and hemostasis, Paeoniae Alba can also astringe yin and nourish blood, calm liver and soften liver, Zhuge thorn head, lotus root joints stop bleeding, dissipate blood stasis, detumescence, Imperata coronata root clears heat and diuresis, calcined Oysters are astringent and astringent, Albizia Julibrissin is used as an adjuvant medicine to regulate qi, soothe the nerves, and activate collaterals; licorice harmonizes the properties of medicines, and it is used as an adjuvant medicine.
以上诸药合用，各药性相互配合、环环相扣，共奏滋阴清热、凉血止血之功。共同达到治愈阴虚火旺型紫癜的目的。The above-mentioned medicines are used in combination, and the properties of each medicine cooperate with each other and interlock with each other to play the merits of nourishing yin and clearing heat, cooling blood and stopping bleeding. Together to achieve the purpose of curing purpura due to yin deficiency and hyperactivity of fire.
制备、服用方法及用量：Preparation, administration method and dosage:
取本发明方，粉碎过80-200目筛，用8-10倍凉水浸泡30-60分钟。第一遍武火煎沸，改文火煎沸30分钟，滤出滤液。第二遍，向药渣中加4-5倍水，武火煎沸，改文火煎沸40分钟，滤出滤液。两遍滤液混合，即得本发明中药组合物。分两次早晚饭后30分钟温服，每次150ml。服药期间忌食腥辣。Get the prescription of the present invention, pulverize through 80-200 mesh sieve, soak with 8-10 times cold water for 30-60 minutes. The first time is boiling with strong fire, then change to simmer for 30 minutes, and filter out the filtrate. For the second time, add 4-5 times of water to the medicinal residues, decoct with strong fire, change to simmer for 40 minutes, and filter out the filtrate. Two filtrates are mixed to obtain the Chinese medicine composition of the present invention. Take it warmly 30 minutes after breakfast and dinner twice, 150ml each time. Do not eat fishy or spicy food while taking the medicine.
下面，结合实施例对本发明的制备方法做详细阐述。Below, the preparation method of the present invention is described in detail in conjunction with examples.
实施例1:Example 1:
（1）称取菟丝子35克、玉竹35克、枸杞子30克、大黄18克、槐角18克、知母18克、黄柏18克、牡丹皮15克、腊里叶18克、紫草18克、仙鹤草18克、白芍18克、猪哥刺头15克、藕节15克、白茅根15克、煅牡蛎15克、合欢花15克、甘草12克；(1) Weigh 35 grams of dodder, 35 grams of Polygonatum odoratum, 30 grams of medlar, 18 grams of rhubarb, 18 grams of Huaijiao, 18 grams of Anemarrhena, 18 grams of Cortex Phellodendri, 15 grams of Moutan bark, 18 grams of Lali leaves, comfrey 18 grams, 18 grams of agrimony, 18 grams of white peony root, 15 grams of Zhuge thorn head, 15 grams of lotus root, 15 grams of Imperata prawn, 15 grams of calcined oyster, 15 grams of albizia julibrissin, 12 grams of licorice;
（2）将上述重量的中药组合物粉碎过120目筛，用8倍凉水浸泡60分钟。第一遍武火煎沸，改文火煎沸30分钟，滤出滤液。第二遍，向药渣中加4倍水，武火煎沸，改文火煎沸40分钟，滤出滤液。两遍滤液混合，即得本发明中药组合物。(2) Pulverize the above-mentioned traditional Chinese medicine composition through a 120-mesh sieve, and soak in 8 times cold water for 60 minutes. The first time is boiling with strong fire, then change to simmer for 30 minutes, and filter out the filtrate. For the second time, add 4 times the water to the medicinal residues, boil with strong fire, change to slow fire for 40 minutes, and filter out the filtrate. Two filtrates are mixed to obtain the Chinese medicine composition of the present invention.
实施例2:Example 2:
（1）称取菟丝子18克、玉竹18克、枸杞子12克、大黄10克、槐角10克、知母10克、黄柏10克、牡丹皮10克、腊里叶10克、紫草10克、仙鹤草10克、白芍10克、猪哥刺头10克、藕节10克、白茅根10克、煅牡蛎10克、合欢花10克、甘草8克；(1) Weigh 18 grams of dodder, 18 grams of Polygonatum odoratum, 12 grams of medlar, 10 grams of rhubarb, 10 grams of Huaijiao, 10 grams of Anemarrhena, 10 grams of Phellodendron cortex, 10 grams of Moutan bark, 10 grams of Lali leaves, comfrey 10 grams, 10 grams of agrimony, 10 grams of white peony root, 10 grams of Zhuge thorn head, 10 grams of lotus root, 10 grams of Imperata chinensis root, 10 grams of calcined oyster, 10 grams of albizia julibrissin, 8 grams of licorice;
（2）将上述重量的中药组合物粉碎过80目筛，用10倍凉水浸泡45分钟。第一遍武火煎沸，改文火煎沸30分钟，滤出滤液。第二遍，向药渣中加5倍水，武火煎沸，改文火煎沸40分钟，滤出滤液。两遍滤液混合，即得本发明中药组合物。(2) The traditional Chinese medicine composition of the above weight is crushed through an 80-mesh sieve, and soaked in 10 times cold water for 45 minutes. The first time is boiling with strong fire, then change to simmer for 30 minutes, and filter out the filtrate. For the second time, add 5 times of water to the medicinal residues, boil with strong fire, change to simmer for 40 minutes, and filter out the filtrate. Two filtrates are mixed to obtain the Chinese medicine composition of the present invention.
实施例3:Embodiment 3:
（1）称取菟丝子25克、玉竹25克、枸杞子25克、大黄15克、槐角15克、知母15克、黄柏15克、牡丹皮12克、腊里叶15克、紫草15克、仙鹤草15克、白芍15克、猪哥刺头12克、藕节12克、白茅根12克、煅牡蛎12克、合欢花12克、甘草10克；(1) Weigh 25 grams of dodder seed, 25 grams of Polygonatum odoratum, 25 grams of medlar, 15 grams of rhubarb, 15 grams of Huaijiao, 15 grams of Anemarrhena, 15 grams of Phellodendron cortex, 12 grams of Moutan bark, 15 grams of Lali leaf, comfrey 15 grams, 15 grams of agrimony, 15 grams of white peony root, 12 grams of Zhuge thorn head, 12 grams of lotus root, 12 grams of Imperata rhizome, 12 grams of calcined oyster, 12 grams of albizia julibrissin, 10 grams of licorice;
（2）将上述重量的中药组合物粉碎过100目筛，用10倍凉水浸泡50分钟。第一遍武火煎沸，改文火煎沸30分钟，滤出滤液。第二遍，向药渣中加4倍水，武火煎沸，改文火煎沸40分钟，滤出滤液。两遍滤液混合，即得本发明中药组合物。(2) Pulverize the above-mentioned traditional Chinese medicine composition through a 100-mesh sieve, and soak in 10 times cold water for 50 minutes. The first time is boiling with strong fire, then change to simmer for 30 minutes, and filter out the filtrate. For the second time, add 4 times the water to the medicinal residues, boil with strong fire, change to slow fire for 40 minutes, and filter out the filtrate. Two filtrates are mixed to obtain the Chinese medicine composition of the present invention.
下面通过临床实验对本发明的疗效进行验证。The curative effect of the present invention is verified below by clinical experiment.
临床资料clinical information
1.1病例选择：1.1 Case selection:
45例观察病例为2010年6月-2013年10月临沂市郯城县皮防站门诊紫癜患者,符合《中华人民共和国中医药行业标准——中医病证诊断疗效标准》（ZY／T001.1～001.9-94）有关阴虚火旺型紫癜诊断标准。其中男21例,女24例,年龄5～35岁,平均年龄19岁; 均以皮肤紫癜为主症，伴手足心热、盗汗、口干、便干、齿衄、鼻衄、月经过多等症。The 45 observed cases were purpura patients in the outpatient clinic of Pifang Station, Tancheng County, Linyi City from June 2010 to October 2013. 001.9-94) diagnostic criteria for purpura due to yin deficiency and hyperactivity of fire. Among them, there were 21 males and 24 females, aged 5 to 35 years, with an average age of 19 years; all of them had skin purpura as the main symptom, accompanied by hot hands and feet, night sweats, dry mouth, dry stool, bleeding teeth, epistaxis, and menorrhagia embolism.
1.2 治疗方法1.2 Treatment methods
予以患者本发明中药组合物，分两次早晚饭后30分钟温服，每次150ml。服药期间忌食腥辣。连续服用2周。Give patient Chinese medicine composition of the present invention, divide and take warmly in 30 minutes after meal twice, each 150ml. Do not eat fishy or spicy food while taking the medicine. Take continuously for 2 weeks.
1.3 疗效评定标准：1.3 Criteria for evaluating curative effect:
根据《中华人民共和国中医药行业标准——中医病证诊断疗效标准》（ZY／T001.1～001.9-94）拟定：According to the "People's Republic of China Traditional Chinese Medicine Industry Standards - Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Syndrome" (ZY/T001.1-001.9-94):
治愈：紫斑紫点及全身症状消失，实验室指标恢复正常；Cure: purpura and purple spots and systemic symptoms disappear, and laboratory indicators return to normal;
好转：皮肤青紫斑点明显减少，全身症状减轻，实验室指标有改善；Improvement: Skin cyanosis spots are significantly reduced, systemic symptoms are relieved, and laboratory indicators are improved;
未愈：皮肤青紫斑点、全身症状及实验室指标均无变化；Unhealed: Skin cyanosis, systemic symptoms and laboratory indicators have no change;
有效率为治愈率、好转率之和。The effective rate is the sum of the cure rate and the recovery rate.
1.4 治疗结果1.4 Treatment Outcomes
45例患者治愈32例(71.11%)，好转12例(26.67%)，未愈1例(2.22%)，有效率为97.78%。对于45例患者在治疗过程中进行跟踪观察，未发现明显的不良反应。Of the 45 patients, 32 were cured (71.11%), 12 were improved (26.67%), and 1 was not cured (2.22%). The effective rate was 97.78%. During the follow-up observation of 45 patients, no obvious adverse reactions were found.
典型病例：Typical cases:
病例1：韩某，女，12岁，学生。2010 年8月就诊。经检查，上肢出现紫癜。舌红，少苔，手足烦热，常盗汗，诊断为过敏性紫癜，中医分型为阴虚火旺型。服本发明方，一疗程病愈。继续服用一疗程后停药，随访2年，未复发。Case 1: Han, female, 12 years old, student. Visited in August 2010. After examination, purpura appeared in the upper extremities. Red tongue, less moss, restless hands and feet, frequent night sweats, diagnosed as allergic purpura, Chinese medicine classification as yin deficiency fire hyperactivity type. Take the prescription of the present invention, and recover after a course of treatment. After continuing to take a course of treatment, the drug was withdrawn, followed up for 2 years, and there was no recurrence.
病例2：魏某某，男，35 岁，农民。2010年 6月就诊。近一周因牙龈出血，手足烦热，左腿出现青紫斑块，入院诊治时结合舌诊和脉诊，定为阴虚火旺型紫癜。给予本发明方治疗，服药一疗程，病情明显好转。继续服用两疗程后病愈。随访3年未复发。Case 2: Wei Moumou, male, 35 years old, farmer. Visited a doctor in June, 2010. In the past week, due to gingival bleeding, hot hands and feet, and cyanotic plaques on the left leg, combined with tongue diagnosis and pulse diagnosis when admitted to the hospital, it was determined to be Yin-deficiency fire-excessive purpura. Give side treatment of the present invention, take medicine a course for the treatment of, the state of an illness obviously takes a turn for the better. After continuing to take two courses of treatment, recover from illness. Follow up a case by regular visits to 3 years without recurrence.
病例3:：王某某，女，21岁，公司职员。2013 年 4 月就诊。检查为皮肤大面积紫癜、午后潮红，盗汗，月经过多，在外院应用激素，静脉丙种球蛋白及多种中西药物治疗，效果欠佳。结合舌诊和脉诊，中医分型为阴虚火旺型紫癜。服本发明方，两疗程病愈。继续服用一疗程后停药，随访2年，未复发。Case 3:: Wang Moumou, female, 21 years old, a company employee. Visited in April 2013. Examination showed extensive skin purpura, afternoon flushing, night sweats, and menorrhagia. She was treated with hormones, intravenous gamma globulin, and various Chinese and Western medicines in other hospitals, but the effect was not satisfactory. Combined with tongue diagnosis and pulse diagnosis, the TCM classification is Yin-deficiency-fire-excessive purpura. Take the prescription of the present invention, two courses of treatment recover from illness. After continuing to take a course of treatment, the drug was withdrawn, followed up for 2 years, and there was no recurrence.
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